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Nobuyuki Ito

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Co-Publications
Name
99
Shirai, Tomoyuki
75
Hirose, Masao
45
Imaida, Katsumi
37
Takahashi, Satoru
30
Tamano, Seiko
30
Tsuda, Hiroyuki
20
Ogawa, Kumiko
17
Tanaka, Harunari
17
Asamoto, Makoto
14
Hoshiya, Toru
12
Ogiso, Tadashi
11
Futakuchi, Mitsuru
10
Sano, Masashi
10
Tiwawech, Danai
9
Cui, L

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Publications

TOP 3
Ito Nobuyuki; Tamano Seiko; Shirai Tomoyuki
A medium-term rat liver bioassay for rapid in vivo detection of carcinogenic potential of chemicals.
Ito Nobuyuki
Genetically modified foods: hazard identification and risk assessment. Session summary.
Ito N; Imaida K; Asamoto M; Shirai T
Early detection of carcinogenic substances and modifiers in rats.

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All Publications

2003: Ito Nobuyuki; Tamano Seiko; Shirai Tomoyuki
A medium-term rat liver bioassay for rapid in vivo detection of carcinogenic potential of chemicals.
Cancer science 2003;94(1):3-8.
2002: Ito Nobuyuki
Genetically modified foods: hazard identification and risk assessment. Session summary.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2002;54(1):57-9.
2000: Ito N; Imaida K; Asamoto M; Shirai T
Early detection of carcinogenic substances and modifiers in rats.
Mutation research 2000;462(2-3):209-17.
2000: Imaida K; Ogawa K; Takahashi S; Ito T; Yamaguchi T; Totsuka Y; Wakabayashi K; Tanaka K; Ito N; Shirai T
Delay of DNA-adduct repair and severe toxicity in xeroderma pigmentosum group A gene (XPA) deficient mice treated with 2-amino-1-methyl-6-phenyl-imidazo [4,5-b] pyridine (PhIP).
Cancer letters 2000;150(1):63-9.
1999: Shirai T; Cui L; Takahashi S; Futakuchi M; Asamoto M; Kato K; Ito N
Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) in the rat prostate and induction of invasive carcinomas by subsequent treatment with testosterone propionate.
Cancer letters 1999;143(2):217-21.
1999: Sano M; Hagiwara A; Tamano S; Hasegawa R; Imaida K; Ito N; Shirai T
Dose-dependent induction of carcinomas and glutathione S-transferase placental form negative eosinophilic foci in the rat liver by di(2-ethylhexyl)phthalate after diethylnitrosamine initiation.
The Journal of toxicological sciences 1999;24(3):177-86.
1999: Shirai T; Hirose M; Ito N
Medium-term bioassays in rats for rapid detection of the carcinogenic potential of chemicals.
IARC scientific publications 1999;(146):251-72.
1998: Shirai T; Takahashi S; Cui L; Yamada Y; Tada M; Kadlubar F F; Ito N
Use of polyclonal antibodies against carcinogen-DNA adducts in analysis of carcinogenesis.
Toxicology letters 1998;102-103():441-6.
1998: Ito N; Imaida K; Hirose M; Shirai T
Medium-term bioassays for carcinogenicity of chemical mixtures.
Environmental health perspectives 1998;106 Suppl 6():1331-6.
1998: Imaida K; Taki M; Watanabe S; Kamimura Y; Ito T; Yamaguchi T; Ito N; Shirai T
The 1.5 GHz electromagnetic near-field used for cellular phones does not promote rat liver carcinogenesis in a medium-term liver bioassay.
Japanese journal of cancer research : Gann 1998;89(10):995-1002.
1998: Ito N; Imaida K; Tamano S; Hagiwara A; Shirai T
Medium-term bioassays as alternative carcinogenicity test.
The Journal of toxicological sciences 1998;23 Suppl 2():103-6.
1998: Imaida K; Taki M; Yamaguchi T; Ito T; Watanabe S; Wake K; Aimoto A; Kamimura Y; Ito N; Shirai T
Lack of promoting effects of the electromagnetic near-field used for cellular phones (929.2 MHz) on rat liver carcinogenesis in a medium-term liver bioassay.
Carcinogenesis 1998;19(2):311-4.
1998: Hasegawa R; Futakuchi M; Mizoguchi Y; Yamaguchi T; Shirai T; Ito N; Lijinsky W
Studies of initiation and promotion of carcinogenesis by N-nitroso compounds.
Cancer letters 1998;123(2):185-91.
1997: Ito N; Hasegawa R; Imaida K; Tamano S; Hagiwara A; Hirose M; Shirai T
Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the rat.
Mutation research 1997;376(1-2):107-14.
1997: Kawabe M; Shibata M A; Sano M; Takesada Y; Tamano S; Ito N; Shirai T
Decrease of prostaglandin E2 and 5-bromo-2'-deoxyuridine labeling but not prostate tumor development by indomethacin treatment of rats given 3,2'-dimethyl-4-aminobiphenyl and testosterone propionate.
Japanese journal of cancer research : Gann 1997;88(4):350-5.
1997: Takaba K; Hirose M; Yoshida Y; Kimura J; Ito N; Shirai T
Effects of n-tritriacontane-16,18-dione, curcumin, chlorphyllin, dihydroguaiaretic acid, tannic acid and phytic acid on the initiation stage in a rat multi-organ carcinogenesis model.
Cancer letters 1997;113(1-2):39-46.
1996: Hasegawa R; Kato T; Hirose M; Takahashi S; Shirai T; Ito N
Enhancement of hepatocarcinogenesis by combined administration of food-derived heterocyclic amines at low doses in the rat.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1996;34(11-12):1097-101.
1996: Ito N; Hagiwara A; Tamano S; Futacuchi M; Imaida K; Shirai T
Effects of pesticide mixtures at the acceptable daily intake levels on rat carcinogenesis.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1996;34(11-12):1091-6.
1996: Hasegawa R; Yoshimura I; Imaida K; Ito N; Shirai T
Analysis of synergism in hepatocarcinogenesis based on preneoplastic foci induction by 10 heterocyclic amines in the rat.
Japanese journal of cancer research : Gann 1996;87(11):1125-33.
1996: Imaida K; Hagiwara A; Yada H; Masui T; Hasegawa R; Hirose M; Sugimura T; Ito N; Shirai T
Dose-dependent induction of mammary carcinomas in female Sprague-Dawley rats with 2-amino-1-methyl-6-phenylimidazol[4,5-b]pyridine.
Japanese journal of cancer research : Gann 1996;87(11):1116-20.
1996: Futakuchi M; Lijinsky W; Hasegawa R; Hirose M; Ito N; Shirai T
Effects of low dose mixtures of four N-nitroso compounds on hepatic foci development in the rat.
Cancer letters 1996;106(2):263-9.
1996: Thamavit W; Tiwawech D; Moore M A; Ito N; Shirai T
Equivocal evidence of complete carcinogenicity after repeated infection of Syrian hamsters with Opisthorchis viverrini.
Toxicologic pathology 1996;24(4):493-7.
1996: Mori T; Cui L; Kato K; Takahashi S; Imaida K; Iwasaki S; Ito N; Shirai T
Direct effects of testosterone, dihydrotestosterone and estrogen on 3,2'-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in castrated F344 rats.
Japanese journal of cancer research : Gann 1996;87(6):570-4.
1996: Futakuchi M; Hasegawa R; Yamamoto A; Cui L; Ogiso T; Ito N; Shirai T
Low susceptibility of the spontaneously hypertensive rat (SHR) to quinoline-induction of hepatic hemangioendothelial sarcomas.
Cancer letters 1996;104(1):37-41.
1996: Takahashi S; Imaida K; Shirai T; Wakabayashi K; Nagao M; Sugimura T; Ito N
Chronic administration of the mutagenic heterocyclic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine induces cardiac damage with characteristic mitochondrial changes in Fischer rats.
Toxicologic pathology 1996;24(3):273-7.
1996: Sano M; Miyata E; Tamano S; Hagiwara A; Ito N; Shirai T
Lack of carcinogenicity of tamarind seed polysaccharide in B6C3F1 mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1996;34(5):463-7.
1996: Kawabe M; Takesada Y; Tamano S; Hagiwara A; Ito N; Shirai T
Subchronic toxicity study of L-isoleucine in F344 rats.
Journal of toxicology and environmental health 1996;47(5):499-508.
1996: Kimura J; Hasegawa R; Yaono M; Kato T; Wakabayashi K; Sugimura T; Ito N; Shirai T
Inhibitory potential of pregnancy and lactation on mammary carcinogenesis induced by a food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, in Sprague-Dawley rats.
Cancer letters 1996;101(1):73-8.
1996: Wada S; Kato T; Mutai M; Ozaki K; Yamaguchi S; Kim D J; Baba-Toriyama H; Asamoto M; Ito N; Tsuda H
Modifying influence of swine-serum-induced liver fibrosis on development of preneoplastic lesions in rat liver.
Japanese journal of cancer research : Gann 1996;87(3):240-6.
1996: Ito N; Hasegawa R; Imaida K; Hirose M; Shirai T
Medium-term liver and multi-organ carcinogenesis bioassays for carcinogens and chemopreventive agents.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1996;48(2-3):113-9.
1996: Ogawa K; Imaida K; Masui T; Kawabe M; Hasegawa R; Kato K; Ito N; Shirai T
Chemically induced lung and forestomach neoplasias in transgenic mice carry mutant forms of the human c-Ha-ras transgene.
Carcinogenesis 1996;17(2):341-5.
1996: Cabral R; Hoshiya T; Hakoi K; Hasegawa R; Ito N
Medium-term bioassay for the hepatocarcinogenicity of hexachlorobenzene.
Cancer letters 1996;100(1-2):223-6.
1996: Kato T; Hasegawa R; Nakae D; Hirose M; Yaono M; Cui L; Kobayashi Y; Konishi Y; Ito N; Shirai T
Dose-dependent induction of 8-hydroxyguanine and preneoplastic foci in rat liver by a food-derived carcinogen, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, at low dose levels.
Japanese journal of cancer research : Gann 1996;87(2):127-33.
1996: Hagiwara A; Kokubo Y; Takesada Y; Tanaka H; Tamano S; Hirose M; Shirai T; Ito N
Inhibitory effects of phenolic compounds on development of naturally occurring preneoplastic hepatocytic foci in long-term feeding studies using male F344 rats.
Teratogenesis, carcinogenesis, and mutagenesis 1996;16(6):317-25.
1995: Hirose M; Hasegawa R; Kimura J; Akagi K; Yoshida Y; Tanaka H; Miki T; Satoh T; Wakabayashi K; Ito N
Inhibitory effects of 1-O-hexyl-2,3,5-trimethylhydroquinone (HTHQ), green tea catechins and other antioxidants on 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1)-induced rat hepatocarcinogenesis and dose-dependent inhibition by HTHQ of lesion induction by Glu-P-1 or 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx).
Carcinogenesis 1995;16(12):3049-55.
1995: Ito N; Hagiwara A; Tamano S; Hasegawa R; Imaida K; Hirose M; Shirai T
Lack of carcinogenicity of pesticide mixtures administered in the diet at acceptable daily intake (ADI) dose levels in rats.
Toxicology letters 1995;82-83():513-20.
1995: Ito N; Hasegawa R; Imaida K; Hirose M; Asamoto M; Shirai T
Concepts in multistage carcinogenesis.
Critical reviews in oncology/hematology 1995;21(1-3):105-133.
1995: Shibata M; Hasegawa R; Imaida K; Hagiwara A; Ogawa K; Hirose M; Ito N; Shirai T
Chemoprevention by dehydroepiandrosterone and indomethacin in a rat multiorgan carcinogenesis model.
Cancer research 1995;55(21):4870-4.
1995: Ogawa K; Shichino Y; Tatematsu M; Furihata C; Asamoto M; Nagase S; Shirai T; Ito N
Increasing development of pepsinogen-altered pyloric glands and adenocarcinoma in glandular stomach of analbuminemic rats.
Cancer letters 1995;96(2):219-24.
1995: Hasegawa R; Hirose M; Kato T; Hagiwara A; Boonyaphiphat P; Nagao M; Ito N; Shirai T
Inhibitory effect of chlorophyllin on PhIP-induced mammary carcinogenesis in female F344 rats.
Carcinogenesis 1995;16(9):2243-6.
1995: Hirose M; Iwata S; Ito E; Nihro Y; Takahashi S; Mizoguchi Y; Miki T; Satoh T; Ito N; Shirai T
Strong anti-mutagenic activity of the novel lipophilic antioxidant 1-O-hexyl-2,3,5-trimethylhydroquinone against heterocyclic amine-induced mutagenesis in the Ames assay and its effect on metabolic activation of 2-amino-6-methyldipyrido[1,2-a:3',2'-d] imidazole (Glu-p-1).
Carcinogenesis 1995;16(9):2227-32.
1995: Yaono M; Hasegawa R; Mizoguchi Y; Futakuchi M; Nakamura T; Ito N; Shirai T
Hepatocyte growth factor enhancement of preneoplastic hepatic foci development in rats treated with diethylnitrosamine and N-ethyl-N-hydroxyethylnitrosamine.
Japanese journal of cancer research : Gann 1995;86(8):718-23.
1995: Akagi K; Hirose M; Hoshiya T; Mizoguchi Y; Ito N; Shirai T
Modulating effects of ellagic acid, vanillin and quercetin in a rat medium term multi-organ carcinogenesis model.
Cancer letters 1995;94(1):113-21.
1995: Masui T; Shirai T; Imaida K; Hirose M; Futakuchi M; Tatematsu M; Ito N
Ki-ras mutations with frequent normal allele loss versus absence of p53 mutations in rat prostate and seminal vesicle carcinomas induced with 3,2'-dimethyl-4-aminobiphenyl.
Molecular carcinogenesis 1995;13(1):21-6.
1995: Tanaka H; Hirose M; Hagiwara A; Imaida K; Shirai T; Ito N
Rat strain differences in catechol carcinogenicity to the stomach.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1995;33(2):93-8.
1995: Ito N; Hasegawa R; Imaida K; Kurata Y; Hagiwara A; Shirai T
Effect of ingestion of 20 pesticides in combination at acceptable daily intake levels on rat liver carcinogenesis.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1995;33(2):159-63.
1995: Hirose M; Akagi K; Hasegawa R; Yaono M; Satoh T; Hara Y; Wakabayashi K; Ito N
Chemoprevention of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP)-induced mammary gland carcinogenesis by antioxidants in F344 female rats.
Carcinogenesis 1995;16(2):217-21.
1995: Hasegawa R; Ogiso T; Imaida K; Shirai T; Ito N
Analysis of the potential carcinogenicity of coffee and its related compounds in a medium-term liver bioassay of rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1995;33(1):15-20.
1995: Kato T; Ogiso T; Kato K; Sano M; Hasegawa R; Shirai T; Ito N
Lack of promoting activity of four pesticides on induction of preneoplastic liver cell foci in rats.
Teratogenesis, carcinogenesis, and mutagenesis 1995;15(5):251-7.
1995: Ito N; Hasegawa R; Asakawa E; Hirose M; Imaida K; Hagiwara A
Enhancement of rat liver cell foci development by combined treatment with heterocyclic amines at low doses.
Princess Takamatsu symposia 1995;23():251-9.
1995: Shirai T; Tamano S; Sano M; Masui T; Hasegawa R; Ito N
Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rats: dose-response studies.
Princess Takamatsu symposia 1995;23():232-9.
1995: Cabral R; Hakoi K; Hoshiya T; Hasegawa R; Ito N
Lack of carcinogenicity of daminozide, alone or in combination with its contaminant 1,1-dimethylhydrazine, in a medium-term bioassay.
Teratogenesis, carcinogenesis, and mutagenesis 1995;15(6):307-12.
1994: Shibata M A; Shirai T; Ogawa K; Takahashi S; Wild C P; Montesano R; Tsuda H; Ito N
DNA methylation adduct formation and H-ras gene mutations in progression of N-butyl-N-(4-hydroxybutyl)nitrosamine-induced bladder tumors caused by a single exposure to N-methyl-N-nitrosourea.
Carcinogenesis 1994;15(12):2965-8.
1994: Hasegawa R; Tanaka H; Tamano S; Shirai T; Nagao M; Sugimura T; Ito N
Synergistic enhancement of small and large intestinal carcinogenesis by combined treatment of rats with five heterocyclic amines in a medium-term multi-organ bioassay.
Carcinogenesis 1994;15(11):2567-73.
1994: Itoh M; Pairojkul C; Thamawit W; Sithithaworn P; Tiwawech D; Uttaravicien T; Shirai T; Ito N
Association of antibodies to Opisthorchis viverrini with hepatobiliary disease in northeastern Thailand.
The American journal of tropical medicine and hygiene 1994;51(4):424-9.
1994: Shirai T; Tada M; Kojima M; Hasegawa R; Masui T; Ito N
DNA adducts in target and nontarget tissues of 3,2'-dimethyl-4-aminobiphenyl in rats.
Environmental health perspectives 1994;102 Suppl 6():167-72.
1994: Tamano S; Hasegawa R; Hagiwara A; Nagao M; Sugimura T; Ito N
Carcinogenicity of a mutagenic compound from food, 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeA alpha C), in male F344 rats.
Carcinogenesis 1994;15(9):2009-15.
1994: Hasegawa R; Yoshida T; Mizoguchi Y; Futakuchi M; Kim D J; Cui L; Ito N
Phenotypic alteration of hepatocellular foci in rats treated with clofibrate and phenobarbital.
Cancer letters 1994;83(1-2):89-95.
1994: Hirose M; Hoshiya T; Akagi K; Futakuchi M; Ito N
Inhibition of mammary gland carcinogenesis by green tea catechins and other naturally occurring antioxidants in female Sprague-Dawley rats pretreated with 7,12-dimethylbenz[alpha]anthracene.
Cancer letters 1994;83(1-2):149-56.
1994: Shirai T; Sano M; Imaida K; Takahashi S; Mori T; Ito N
Duration dependent induction of invasive prostatic carcinomas with pharmacological dose of testosterone propionate in rats pretreated with 3,2'-dimethyl-4-aminobiphenyl and development of androgen-independent carcinomas after castration.
Cancer letters 1994;83(1-2):111-6.
1994: Tanaka H; Hagiwara A; Kurata Y; Ogiso T; Futakuchi M; Ito N
Thirteen-week oral toxicity study of magnesium chloride in B6C3F1 mice.
Toxicology letters 1994;73(1):25-32.
1994: Hasegawa R; Miyata E; Futakuchi M; Hagiwara A; Nagao M; Sugimura T; Ito N
Synergistic enhancement of hepatic foci development by combined treatment of rats with 10 heterocyclic amines at low doses.
Carcinogenesis 1994;15(5):1037-41.
1994: Puapairoj P; Cui L; Ogawa K; Akagi K; Hasegawa R; Ito N
Effect of ethanol on paraquat toxicity in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1994;32(4):379-86.
1994: Thamavit W; Pairojkul C; Tiwawech D; Shirai T; Ito N
Strong promoting effect of Opisthorchis viverrini infection on dimethylnitrosamine-initiated hamster liver.
Cancer letters 1994;78(1-3):121-5.
1994: Shirai T; Imaida K; Masui T; Iwasaki S; Mori T; Kato T; Ito N
Effects of testosterone, dihydrotestosterone and estrogen on 3,2'-dimethyl-4-aminobiphenyl-induced rat prostate carcinogenesis.
International journal of cancer. Journal international du cancer 1994;57(2):224-8.
1994: Asakawa E; Hirose M; Hagiwara A; Takahashi S; Ito N
Carcinogenicity of 4-methoxyphenol and 4-methylcatechol in F344 rats.
International journal of cancer. Journal international du cancer 1994;56(1):146-52.
1994: Yoshida Y; Hirose M; Takaba K; Kimura J; Ito N
Induction and promotion of forestomach tumors by sodium nitrite in combination with ascorbic acid or sodium ascorbate in rats with or without N-methyl-N'-nitro-N-nitrosoguanidine pre-treatment.
International journal of cancer. Journal international du cancer 1994;56(1):124-8.
1994: Cui L; Hasegawa R; Zajdela F; Puapairoj P; Shirai T; Ito N
Lack of promoting activity of 7-methoxy-2-nitro-naphtho-[2,1-b]furan (R7000) in a medium-term rat liver bioassay.
Cancer letters 1994;76(2-3):161-6.
1994: Ito N; Hasegawa R; Imaida K; Takahashi S; Shirai T
Medium-term rat liver bioassay for rapid detection of carcinogens and modifiers of hepatocarcinogenesis.
Drug metabolism reviews 1994;26(1-2):431-42.
1994: Thamavit W; Pairojkul C; Tiwawech D; Shirai T; Ito N
Lack of promoting effect of proline on bile duct cancer development in dimethylnitrosamine-initiated hamster livers.
Teratogenesis, carcinogenesis, and mutagenesis 1994;14(4):169-74.
1993: Hasegawa R; Sano M; Tamano S; Imaida K; Shirai T; Nagao M; Sugimura T; Ito N
Dose-dependence of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP) carcinogenicity in rats.
Carcinogenesis 1993;14(12):2553-7.
1993: Ito N; Hirose M; Takahashi S
Cell proliferation and forestomach carcinogenesis.
Environmental health perspectives 1993;101 Suppl 5():107-10.
1993: Takahashi S; Shirai T; Ogawa K; Imaida K; Yamazaki C; Ito A; Masuko K; Ito N
Renal cell adenomas and carcinomas in hemodialysis patients: relationship between hemodialysis period and development of lesions.
Acta pathologica japonica 1993;43(11):674-82.
1993: Thamavit W; Pairojkul C; Tiwawech D; Itoh M; Shirai T; Ito N
Promotion of cholangiocarcinogenesis in the hamster liver by bile duct ligation after dimethylnitrosamine initiation.
Carcinogenesis 1993;14(11):2415-7.
1993: Hirose M; Yada H; Hakoi K; Takahashi S; Ito N
Modification of carcinogenesis by alpha-tocopherol, t-butylhydroquinone, propyl gallate and butylated hydroxytoluene in a rat multi-organ carcinogenesis model.
Carcinogenesis 1993;14(11):2359-64.
1993: Shirai T; Iwasaki S; Masui T; Mori T; Kato T; Ito N
Enhancing effect of cadmium on rat ventral prostate carcinogenesis induced by 3,2'-dimethyl-4-aminobiphenyl.
Japanese journal of cancer research : Gann 1993;84(10):1023-30.
1993: Yoshida Y; Tatematsu M; Takaba K; Iwasaki S; Ito N
Target organ specificity of cell proliferation induced by various carcinogens.
Toxicologic pathology 1993;21(5):436-42.
1993: Hoshiya T; Hasegawa R; Hakoi K; Cui L; Ogiso T; Cabral R; Ito N
Enhancement by non-mutagenic pesticides of GST-P positive hepatic foci development initiated with diethylnitrosamine in the rat.
Cancer letters 1993;72(1-2):59-64.
1993: Hirose M; Hoshiya T; Akagi K; Takahashi S; Hara Y; Ito N
Effects of green tea catechins in a rat multi-organ carcinogenesis model.
Carcinogenesis 1993;14(8):1549-53.
1993: Kawabe M; Tamano S; Shibata M A; Hirose M; Fukushima S; Ito N
Subchronic toxicity study of methyl hesperidin in mice.
Toxicology letters 1993;69(1):37-44.
1993: Shibata M A; Hirose M; Masuda A; Kato T; Mutai M; Ito N
Modification of BHA forestomach carcinogenesis in rats: inhibition by diethylmaleate or indomethacin and enhancement by a retinoid.
Carcinogenesis 1993;14(7):1265-9.
1993: Hasegawa R; Cabral R; Hoshiya T; Hakoi K; Ogiso T; Boonyaphiphat P; Shirai T; Ito N
Carcinogenic potential of some pesticides in a medium-term multi-organ bioassay in rats.
International journal of cancer. Journal international du cancer 1993;54(3):489-93.
1993: Hirose M; Akagi K; Hasegawa R; Satoh T; Nihro Y; Miki T; Sugimura T; Ito N
Strong inhibition of 2-amino-6-methyldipyrido[1,2-a:3',2'-d] imidazole-induced mutagenesis and hepatocarcinogenesis by 1-O-hexyl-2,3,5-trimethylhydroquinone.
Japanese journal of cancer research : Gann 1993;84(5):481-4.
1993: Hagiwara A; Tanaka H; Imaida K; Tamano S; Fukushima S; Ito N
Correlation between medium-term multi-organ carcinogenesis bioassay data and long-term observation results in rats.
Japanese journal of cancer research : Gann 1993;84(3):237-45.
1993: Hirose M; Fukushima S; Tanaka H; Asakawa E; Takahashi S; Ito N
Carcinogenicity of catechol in F344 rats and B6C3F1 mice.
Carcinogenesis 1993;14(3):525-9.
1993: Thamavit W; Moore M A; Sirisinha S; Shirai T; Ito N
Time-dependent modulation of liver lesion development in Opisthorchis-infected Syrian hamster by an antihelminthic drug, praziquantel.
Japanese journal of cancer research : Gann 1993;84(2):135-8.
1993: Shibata M A; Hirose M; Kagawa M; Boonyaphiphat P; Ito N
Enhancing effect of concomitant L-ascorbic acid administration on BHA-induced forestomach carcinogenesis in rats.
Carcinogenesis 1993;14(2):275-80.
1993: Shirai T; Imaida K; Iwasaki S; Mori T; Tada M; Ito N
Sequential observation of rat prostate lesion development induced by 3,2'-dimethyl-4-aminobiphenyl and testosterone.
Japanese journal of cancer research : Gann 1993;84(1):20-5.
1993: Tamano S; Kawabe M; Sano M; Masui T; Ito N
Subchronic oral toxicity study of captafol in B6C3F1 mice.
Journal of toxicology and environmental health 1993;38(1):69-75.
1993: Hirose M; Tanaka H; Takahashi S; Futakuchi M; Fukushima S; Ito N
Effects of sodium nitrite and catechol, 3-methoxycatechol, or butylated hydroxyanisole in combination in a rat multiorgan carcinogenesis model.
Cancer research 1993;53(1):32-7.
1993: Hirose M; Shirai T; Takahashi S; Ogawa K; Ito N
Organ-specific modification of carcinogenesis by antioxidants in rats.
Basic life sciences 1993;61():181-8.
1993: de Camargo J L; Tsuda H; Asamoto M; Tagawa Y; Wada S; Nagase S; Ito N
Modifying effects of chemicals on the development of liver preneoplastic placental glutathione S-transferase positive foci in analbuminemic and Sprague-Dawley rats.
Toxicologic pathology 1993;21(4):409-16.
1993: Hagiwara A; Tiwawech D; Imaida K; Tamano S; Shibata M A; Fukushima S; Ito N
Modifying influence of prior treatment with toxic agents on induction of preneoplastic and neoplastic lesions in a medium-term multi-organ carcinogenesis bioassay.
Teratogenesis, carcinogenesis, and mutagenesis 1993;13(6):277-87.
1992: Hasegawa R; Ogawa K; Takaba K; Shirai T; Ito N
3,2'-Dimethyl-4-aminobiphenyl-induced gallbladder carcinogenesis and effects of ethinyl estradiol in hamsters.
Japanese journal of cancer research : Gann 1992;83(12):1286-92.
1992: Tamano S; Hirose M; Tanaka H; Asakawa E; Ogawa K; Ito N
Forestomach neoplasm induction in F344/DuCrj rats and B6C3F1 mice exposed to sesamol.
Japanese journal of cancer research : Gann 1992;83(12):1279-85.
1992: Ito N; Hasegawa R; Imaida K; Masui T; Takahashi S; Shirai T
Pathological markers for non-genotoxic agent-associated carcinogenesis.
Toxicology letters 1992;64-65 Spec No():613-20.
1992: Hasegawa R; Ito N
Liver medium-term bioassay in rats for screening of carcinogens and modifying factors in hepatocarcinogenesis.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1992;30(11):979-92.
1992: Tsuda H; Ozaki K; Uwagawa S; Yamaguchi S; Hakoi K; Aoki T; Kato T; Sato K; Ito N
Effects of modifying agents on conformity of enzyme phenotype and proliferative potential in focal preneoplastic and neoplastic liver cell lesions in rats.
Japanese journal of cancer research : Gann 1992;83(11):1154-65.
1992: Shichino Y; Tatematsu M; Ohshima H; Bartsch H; Furihata C; Ito N
Effects of hickory-smoke condensate on development of pepsinogen 1-altered pyloric glands in rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1992;30(10):859-64.
1992: Hirose M; Kawabe M; Shibata M; Takahashi S; Okazaki S; Ito N
Influence of caffeic acid and other o-dihydroxybenzene derivatives on N-methyl-N'-nitro-N-nitrosoguanidine-initiated rat forestomach carcinogenesis.
Carcinogenesis 1992;13(10):1825-8.
1992: Hagiwara A; Sano M; Asakawa E; Tanaka H; Hasegawa R; Ito N
Enhancing effects of harman and norharman on induction of preneoplastic and neoplastic kidney lesions in rats initiated with N-ethyl-N-hydroxyethylnitrosamine.
Japanese journal of cancer research : Gann 1992;83(9):949-54.
1992: Tatematsu M; Ogawa K; Hoshiya T; Shichino Y; Kato T; Imaida K; Ito N
Induction of adenocarcinomas in the glandular stomach of BALB/c mice treated with N-methyl-N-nitrosourea.
Japanese journal of cancer research : Gann 1992;83(9):915-8.
1992: Takahashi S; Hakoi K; Yada H; Hirose M; Ito N; Fukushima S
Enhancing effects of diallyl sulfide on hepatocarcinogenesis and inhibitory actions of the related diallyl disulfide on colon and renal carcinogenesis in rats.
Carcinogenesis 1992;13(9):1513-8.
1992: Hasegawa R; Takahashi S; Shirai T; Iwasaki S; Kim D J; Ochiai M; Nagao M; Sugimura T; Ito N
Dose-dependent formation of preneoplastic foci and DNA adducts in rat liver with 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeA alpha C) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
Carcinogenesis 1992;13(8):1427-31.
1992: Uwagawa S; Tsuda H; Ozaki K; Takahashi S; Yamaguchi S; Mutai M; Aoki T; Ito N
Modifying effects of various chemicals on tumor development in a rat wide-spectrum organ carcinogenesis model.
Japanese journal of cancer research : Gann 1992;83(8):812-20.
1992: Hagiwara A; Boonyaphiphat P; Kawabe M; Naito H; Shirai T; Ito N
Lack of carcinogenicity of tragacanth gum in B6C3F1 mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1992;30(8):673-9.
1992: Hasegawa R; Tiwawech D; Hirose M; Takaba K; Hoshiya T; Shirai T; Ito N
Suppression of diethylnitrosamine-initiated preneoplastic foci development in the rat liver by combined administration of four antioxidants at low doses.
Japanese journal of cancer research : Gann 1992;83(5):431-7.
1992: Thamavit W; Moore M A; Ruchirawat S; Ito N
Repeated exposure to Opisthorchis viverrini and treatment with the antihelminthic Praziquantel lacks carcinogenic potential.
Carcinogenesis 1992;13(2):309-11.
1992: Hirose M; Wada S; Yamaguchi S; Masuda A; Okazaki S; Ito N
Reversibility of catechol-induced rat glandular stomach lesions.
Cancer research 1992;52(4):787-90.
1992: Shibata M A; Fukushima S; Asakawa E; Hirose M; Ito N
The modifying effects of indomethacin or ascorbic acid on cell proliferation induced by different types of bladder tumor promoters in rat urinary bladder and forestomach mucosal epithelium.
Japanese journal of cancer research : Gann 1992;83(1):31-9.
1992: Thamavit W; Moore M A; Ruchirawat S; Ito N
Lack of modulation effects of praziquantel on DMN-induced lesion development in the Syrian hamster liver.
Cancer letters 1992;61(3):229-32.
1992: Shirari T; Tamano S; Takahashi S; Ito N
Animal prostate carcinoma models: limited potential for vertebral metastasis.
Advances in experimental medicine and biology 1992;324():151-8.
1992: Hagiwara A; Asakawa E; Kurata Y; Sano M; Hirose M; Ito N
Dose-dependent renal tubular toxicity of harman and norharman in male F344 rats.
Toxicologic pathology 1992;20(2):197-204.
1992: Ito N; Shirai T; Hasegawa R
Medium-term bioassays for carcinogens.
IARC scientific publications 1992;(116):353-88.
1992: Tatematsu M; Hasegawa R; Ogawa K; Kato T; Ichinose M; Miki K; Ito N
Histogenesis of human stomach cancers based on assessment of differentiation.
Journal of clinical gastroenterology 1992;14 Suppl 1():S1-7.
1992: Hakoi K; Cabral R; Hoshiya T; Hasegawa R; Shirai T; Ito N
Analysis of carcinogenic activity of some pesticides in a medium-term liver bioassay in the rat.
Teratogenesis, carcinogenesis, and mutagenesis 1992;12(6):269-76.
1992: Hasegawa R; Wang C Y; Kim D J; Lee M S; Yoshida Y; Ito N
Effect of acyl derivatives of 4,4,4-trifluoro-1-phenyl-1,3-butanedione on 2-acetylaminofluorene-induced glutathione S-transferase positive foci in the rat liver.
Teratogenesis, carcinogenesis, and mutagenesis 1992;12(6):263-8.
1992: Yoshida Y; Tatematsu M; Takaba K; Shichino Y; Ito N
Effects of various bile acids and their sodium salts on development of pepsinogen-altered pyloric glands in rats.
Teratogenesis, carcinogenesis, and mutagenesis 1992;12(4):179-86.
1992: Ito N; Imaida K
Strategy of research for cancer--chemoprevention.
Teratogenesis, carcinogenesis, and mutagenesis 1992;12(2):79-95.
1992: Yoshida Y; Hasegawa R; Takaba K; Imaida K; Ito N
N-nitrosoheptamethyleneimine-induced pulmonary and esophageal carcinogenesis and effects of concomitant treatment with bleomycin in rats.
Teratogenesis, carcinogenesis, and mutagenesis 1992;12(5):197-201.
1991: Uwagawa S; Tsuda H; Inoue T; Tagawa Y; Aoki T; Kagawa M; Ogiso T; Ito N
Enhancing potential of 6 different carcinogens on multi-organ tumorigenesis after initial treatment with N-methyl-N-nitrosourea in rats.
Japanese journal of cancer research : Gann 1991;82(12):1397-405.
1991: Hasegawa R; Shirai T; Hakoi K; Takaba K; Iwasaki S; Hoshiya T; Ito N; Nagao M; Sugimura T
Synergistic enhancement of glutathione S-transferase placental form-positive hepatic foci development in diethylnitrosamine-treated rats by combined administration of five heterocyclic amines at low doses.
Japanese journal of cancer research : Gann 1991;82(12):1378-84.
1991: Shibata M A; Hirose M; Tanaka H; Asakawa E; Shirai T; Ito N
Induction of renal cell tumors in rats and mice, and enhancement of hepatocellular tumor development in mice after long-term hydroquinone treatment.
Japanese journal of cancer research : Gann 1991;82(11):1211-9.
1991: Hirose M; Uwagawa S; Ozaki K; Takaba K; Ito N
Effects of butylated hydroxyanisole pretreatment on low dose N-methyl-N'-nitro-N-nitrosoguanidine- or N,N-dibutylnitrosamine-induced rat forestomach or esophageal carcinogenesis.
Carcinogenesis 1991;12(10):1773-6.
1991: Hagiwara A; Hirose M; Takahashi S; Ogawa K; Shirai T; Ito N
Forestomach and kidney carcinogenicity of caffeic acid in F344 rats and C57BL/6N x C3H/HeN F1 mice.
Cancer research 1991;51(20):5655-60.
1991: Shirai T; Joong K D; Hakoi K; Thamavit W; Pairojkul C; Hoshiya T; Hasegawa R; Ito N
Promotion of rat hepatocarcinogenesis by praziquantel.
Japanese journal of cancer research : Gann 1991;82(10):1085-8.
1991: Hagiwara A; Tanaka H; Tiwawech D; Shirai T; Ito N
Oral toxicity study of tragacanth gum in B6C3F1 mice: development of squamous-cell hyperplasia in the forestomach and its reversibility.
Journal of toxicology and environmental health 1991;34(2):207-18.
1991: Hirose M; Ozaki K; Takaba K; Fukushima S; Shirai T; Ito N
Modifying effects of the naturally occurring antioxidants gamma-oryzanol, phytic acid, tannic acid and n-tritriacontane-16, 18-dione in a rat wide-spectrum organ carcinogenesis model.
Carcinogenesis 1991;12(10):1917-21.
1991: Ito N; Hasegawa R; Sano M; Tamano S; Esumi H; Takayama S; Sugimura T
A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
Carcinogenesis 1991;12(8):1503-6.
1991: Tamano S; Kurata Y; Shibata M; Tanaka H; Ogiso T; Ito N
13-Week oral toxicity study of captafol in F344/DuCrj rats.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1991;17(2):390-8.
1991: Fukushima S; Shibata M A; Hirose M; Kato T; Tatematsu M; Ito N
Organ-specific modification of tumor development by low-dose combinations of agents in a rat wide-spectrum carcinogenesis model.
Japanese journal of cancer research : Gann 1991;82(7):784-92.
1991: Shirai T; Fukushima S; Kawabe M; Shibata M; Iwasaki S; Tada M; Ito N
Selective induction of rat urinary bladder tumors by simultaneous administration of 3,2'-dimethyl-4-aminobiphenyl (DMAB) and butylated hydroxyanisole or butylated hydroxytoluene is associated with increased DMAB-DNA adduct formation.
Carcinogenesis 1991;12(7):1335-9.
1991: Nakamura A; Shirai T; Takahashi S; Ogawa K; Hirose M; Ito N
Lack of modification by naturally occurring antioxidants of 3,2'-dimethyl-4-aminobiphenyl-initiated rat prostate carcinogenesis.
Cancer letters 1991;58(3):241-6.
1991: Tiwawech D; Hasegawa R; Kurata Y; Tatematsu M; Shibata M A; Thamavit W; Ito N
Dose-dependent effects of 2-acetylaminofluorene on hepatic foci development and cell proliferation in rats.
Carcinogenesis 1991;12(6):985-90.
1991: Fukushima S; Hagiwara A; Hirose M; Yamaguchi S; Tiwawech D; Ito N
Modifying effects of various chemicals on preneoplastic and neoplastic lesion development in a wide-spectrum organ carcinogenesis model using F344 rats.
Japanese journal of cancer research : Gann 1991;82(6):642-9.
1991: Cabral R; Hoshiya T; Hakoi K; Hasegawa R; Fukushima S; Ito N
A rapid in vivo bioassay for the carcinogenicity of pesticides.
Tumori 1991;77(3):185-8.
1991: Ito N; Hasegawa R; Shirai T; Fukushima S; Hakoi K; Takaba K; Iwasaki S; Wakabayashi K; Nagao M; Sugimura T
Enhancement of GST-P positive liver cell foci development by combined treatment of rats with five heterocyclic amines at low doses.
Carcinogenesis 1991;12(5):767-72.
1991: Hasegawa R; Takahashi S; Imaida K; Yamaguchi S; Shirai T; Ito N
Age-dependent induction of preneoplastic liver cell foci by 2-acetylaminofluorene, phenobarbital and acetaminophen in F344 rats initially treated with diethylnitrosamine.
Japanese journal of cancer research : Gann 1991;82(3):293-7.
1991: Shirai T; Tamano S; Kato T; Iwasaki S; Takahashi S; Ito N
Induction of invasive carcinomas in the accessory sex organs other than the ventral prostate of rats given 3,2'-dimethyl-4-aminobiphenyl and testosterone propionate.
Cancer research 1991;51(4):1264-9.
1991: Hirose M; Mutai M; Takahashi S; Yamada M; Fukushima S; Ito N
Effects of phenolic antioxidants in low dose combination on forestomach carcinogenesis in rats pretreated with N-methyl-N'-nitro-N-nitrosoguanidine.
Cancer research 1991;51(3):824-7.
1991: Tatematsu M; Ogawa K; Mutai M; Aoki T; Hoshiya T; Ito N
Rapid regression of squamous cell hyperplasia and slow regression of basal cell hyperplasia in the forestomach of F344 rats treated with N-methyl-N'-nitro-N-nitrosoguanidine and/or butylated hydroxyanisole.
Cancer research 1991;51(1):318-23.
1991: Ito N; Shirai T; Fukushima S
Medium-term bioassay for carcinogens using multiorgan models.
Progress in experimental tumor research. Fortschritte der experimentellen Tumorforschung. Progrès de la recherche expérimentale des tumeurs 1991;33():41-57.
1991: Ito N; Shirai T; Masui T; Ogawa K; Kato T; Takahashi S
Mechanistic analysis of multistage carcinogenesis in the rat prostate.
Princess Takamatsu symposia 1991;22():125-33.
1991: Ogawa K; Hasegawa R; Wada S; Yamaguchi S; Ito N
Dose response study of N-nitrosodiethanolamine initiation of rat hepatocarcinogenesis.
Teratogenesis, carcinogenesis, and mutagenesis 1991;11(5):245-50.
1990: Yamaguchi S; Tatematsu M; Furihata C; Takaba K; Ito N
Effects of bile acids on development of pepsinogen-altered pyloric glands in rats.
Cancer letters 1990;55(2):129-34.
1990: Tamano S; Kurata Y; Kawabe M; Yamamoto A; Hagiwara A; Cabral R; Ito N
Carcinogenicity of captafol in F344/DuCrj rats.
Japanese journal of cancer research : Gann 1990;81(12):1222-31.
1990: Imaida K; Hirose M; Yamaguchi S; Takahashi S; Ito N
Effects of naturally occurring antioxidants on combined 1,2-dimethylhydrazine- and 1-methyl-1-nitrosourea-initiated carcinogenesis in F344 male rats.
Cancer letters 1990;55(1):53-9.
1990: Asamoto M; Shichino Y; Tsuda H; Ito N
Inhibition of rat hepatic glutathione S-transferase placental form positive foci development by concomitant administration of antioxidants to carcinogen-treated rats.
Cancer letters 1990;55(1):25-9.
1990: Tatematsu M; Ozaki K; Mutai M; Shichino Y; Furihata C; Ito N
Enhancing effects of various gastric carcinogens on development of pepsinogen-altered pyloric glands in rats.
Carcinogenesis 1990;11(11):1975-8.
1990: Wada S; Hirose M; Takahashi S; Okazaki S; Ito N
Para-methoxyphenol strongly stimulates cell proliferation in the rat forestomach but is not a promoter of rat forestomach carcinogenesis.
Carcinogenesis 1990;11(10):1891-4.
1990: Hagiwara A; Yamada M; Hasegawa R; Fukushima S; Ito N
Lack of enhancing effects of fenvalerate and esfenvalerate on induction of preneoplastic glutathione S-transferase placental form positive liver cell foci in rats.
Cancer letters 1990;54(1-2):67-73.
1990: Kurata Y; Fukushima S; Hagiwara A; Ito H; Ogawa K; Ito N
Carcinogenicity study of methyl hesperidin in B6C3F1 mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1990;28(9):613-8.
1990: Nakamura A; Shirai T; Ogawa K; Wada S; Fujimoto N A; Ito A; Ito N
Promoting action of prolactin released from a grafted transplantable pituitary tumor (MtT/F84) on rat prostate carcinogenesis.
Cancer letters 1990;53(2-3):151-7.
1990: Hirose M; Fukushima S; Hasegawa R; Kato T; Tanaka H; Ito N
Effects of sodium nitrite and catechol or 3-methoxycatechol in combination on rat stomach epithelium.
Japanese journal of cancer research : Gann 1990;81(9):857-61.
1990: Kurata Y; Fukushima S; Hasegawa R; Hirose M; Shibata M; Shirai T; Ito N
Structure-activity relations in promotion of rat urinary bladder carcinogenesis by phenolic antioxidants.
Japanese journal of cancer research : Gann 1990;81(8):754-9.
1990: Tatematsu M; Katsuyama T; Furihata C; Fukushima S; Shirai T; Kato T; Ito N
Cellular differentiation and histogenesis of rat glandular stomach cancers.
Japanese journal of cancer research : Gann 1990;81(8):760-7.
1990: Tatematsu M; Ichinose M; Miki K; Hasegawa R; Kato T; Ito N
Gastric and intestinal phenotypic expression of human stomach cancers as revealed by pepsinogen immunohistochemistry and mucin histochemistry.
Acta pathologica japonica 1990;40(7):494-504.
1990: Shibata M A; Hirose M; Yamada M; Tatematsu M; Uwagawa S; Ito N
Epithelial cell proliferation in rat forestomach and glandular stomach mucosa induced by catechol and analogous dihydroxybenzenes.
Carcinogenesis 1990;11(6):997-1000.
1990: Shibata M A; Fukushima S; Takahashi S; Hasegawa R; Ito N
Enhancing effects of sodium phenobarbital and N,N-dibutylnitrosamine on tumor development in a rat wide-spectrum organ carcinogenesis model.
Carcinogenesis 1990;11(6):1027-31.
1990: Shirai T; Nakamura A; Fukushima S; Yamamoto A; Tada M; Ito N
Different carcinogenic responses in a variety of organs, including the prostate, of five different rat strains given 3,2'-dimethyl-4-aminobiphenyl.
Carcinogenesis 1990;11(5):793-7.
1990: Hirose M; Masuda A; Ito N; Kamano K; Okuyama H
Effects of dietary perilla oil, soybean oil and safflower oil on 7,12-dimethylbenz[a]anthracene (DMBA) and 1,2-dimethyl-hydrazine (DMH)-induced mammary gland and colon carcinogenesis in female SD rats.
Carcinogenesis 1990;11(5):731-5.
1990: Shirai T; Nakamura A; Fukushima S; Tada M; Morita T; Ito N
Immunohistochemical demonstration of carcinogen-DNA adducts in target and non-target tissues of rats given a prostate carcinogen, 3,2'-dimethyl-4-aminobiphenyl.
Carcinogenesis 1990;11(4):653-7.
1990: Ogiso T; Tatematsu M; Tamano S; Hasegawa R; Ito N
Correlation between medium-term liver bioassay system data and results of long-term testing in rats.
Carcinogenesis 1990;11(4):561-6.
1990: Tsuda H; Takahashi S; Yamaguchi S; Ozaki K; Ito N
Comparison of initiation potential of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in an in vivo carcinogen bioassay system.
Carcinogenesis 1990;11(4):549-52.
1990: Shirai T; Nakamura A; Fukushima S; Wang C Y; Yamada H; Ito N
Selective induction of prostate carcinomas in F344 rats treated with intraperitoneal injections of N-hydroxy-3,2'-dimethyl-4-aminobiphenyl.
Japanese journal of cancer research : Gann 1990;81(4):320-3.
1990: Shibata M A; Yamada M; Hirose M; Asakawa E; Tatematsu M; Ito N
Early proliferative responses of forestomach and glandular stomach of rats treated with five different phenolic antioxidants.
Carcinogenesis 1990;11(3):425-9.
1990: Hirose M; Fukushima S; Shirai T; Hasegawa R; Kato T; Tanaka H; Asakawa E; Ito N
Stomach carcinogenicity of caffeic acid, sesamol and catechol in rats and mice.
Japanese journal of cancer research : Gann 1990;81(3):207-12.
1990: Tsuda H; Wada S; Masui T; Inui M; Ito N; Katagiri K; Hoshino M; Inaguma H; Miyaji M; Takeuchi T
Comparative sequential changes in serum and biliary levels of bile acid components after a single dose of D-galactosamine or partial hepatectomy in the rat.
Liver 1990;10(1):28-34.
1990: Mutai M; Tatematsu M; Aoki T; Wada S; Ito N
Modulatory interaction between initial clofibrate treatment and subsequent administration of 2-acetylaminofluorene or sodium phenobarbital on glutathione S-transferase positive lesion development.
Cancer letters 1990;49(2):127-32.
1990: Hirose M; Masuda A; Hasegawa R; Wada S; Ito N
Regression of butylated hydroxyanisole (BHA)-induced hyperplasia but not dysplasia in the forestomach of hamsters.
Carcinogenesis 1990;11(2):239-44.
1990: Ito N; Hirose M; Hagiwara A; Takahashi S
Carcinogenicity and modification of carcinogenic response by antioxidants.
Basic life sciences 1990;52():183-94.
1990: Hagiwara A; Tanaka H; Kurata Y; Kato T; Tsuda H; Ito N
Lack of hepatotoxicity or promotion of enzyme-altered liver foci development in rats treated with harman or norharman.
Journal of toxicology and environmental health 1990;29(2):211-8.
1989: Ito N; Hirose M; Shibata M; Tanaka H; Shirai T
Modifying effects of simultaneous treatment with butylated hydroxyanisole (BHA) on rat tumor induction by 3,2'-dimethyl-4-aminobiphenyl, 2,2'-dihydroxy-di-n-propylnitrosamine and N-methylnitrosourea.
Carcinogenesis 1989;10(12):2255-9.
1989: Hirose M; Kagawa M; Ogawa K; Yamamoto A; Ito N
Antagonistic effect of diethylmaleate on the promotion of forestomach carcinogenesis by butylated hydroxyanisole (BHA) in rats pretreated with N-methyl-N'-nitro-N-nitrosoguanidine.
Carcinogenesis 1989;10(12):2223-6.
1989: Yamaguchi S; Hirose M; Fukushima S; Hasegawa R; Ito N
Modification by catechol and resorcinol of upper digestive tract carcinogenesis in rats treated with methyl-N-amylnitrosamine.
Cancer research 1989;49(21):6015-8.
1989: Asamoto M; Tsuda H; Kato T; Ito N; Masuko T; Hashimoto Y; Nagase S
Strain differences in susceptibility to 2-acetylaminofluorene and phenobarbital promotion of hepatocarcinogenesis: immunohistochemical analysis of cytochrome P-450 isozyme induction by 2-acetylaminofluorene and phenobarbital.
Japanese journal of cancer research : Gann 1989;80(11):1041-6.
1989: Tatematsu M; Mutai M; Inoue K; Ozaki K; Furihata C; Ito N
Synergism between sodium chloride and sodium taurocholate and development of pepsinogen-altered pyloric glands: relevance to a medium-term bioassay system for gastric carcinogens and promoters in rats.
Japanese journal of cancer research : Gann 1989;80(11):1035-40.
1989: Asamoto M; Tsuda H; Kagawa M; de Camargo J L; Ito N; Nagase S
Strain differences in susceptibility to 2-acetylaminofluorene and phenobarbital promotion of rat hepatocarcinogenesis in a medium-term assay system: quantitation of glutathione S-transferase P-positive foci development.
Japanese journal of cancer research : Gann 1989;80(10):939-44.
1989: Hasegawa R; Mutai M; Imaida K; Tsuda H; Yamaguchi S; Ito N
Synergistic effects of low-dose hepatocarcinogens in induction of glutathione S-transferase P-positive foci in the rat liver.
Japanese journal of cancer research : Gann 1989;80(10):945-51.
1989: Kurata Y; Tamano S; Shibata M A; Hagiwara A; Fukushima S; Ito N
Lack of carcinogenicity of magnesium chloride in a long-term feeding study in B6C3F1 mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1989;27(9):559-63.
1989: Hirose M; Yamaguchi S; Fukushima S; Hasegawa R; Takahashi S; Ito N
Promotion by dihydroxybenzene derivatives of N-methyl-N'-nitro-N-nitrosoguanidine-induced F344 rat forestomach and glandular stomach carcinogenesis.
Cancer research 1989;49(18):5143-7.
1989: Fukushima S; Inoue T; Uwagawa S; Shibata M A; Ito N
Co-carcinogenic effects of NaHCO3 on o-phenylphenol-induced rat bladder carcinogenesis.
Carcinogenesis 1989;10(9):1635-40.
1989: Hirose M; Kurata Y; Yamada M; Shirai T; Ito N; Ohsawa T
Lack of modifying effects of linolic acid hydroperoxides and their secondary oxidative products on combined 7,12-dimethylbenz[a]anthracene and 1,2-dimethylhydrazine-initiated mammary gland, ear duct and colon carcinogenesis in female Sprague-Dawley rats.
Cancer letters 1989;47(1-2):141-7.
1989: Shirai T; Nakamura A; Wada S; Ito N
Pancreatic acinar cell tumors in rats induced by 3,2'-dimethyl-4-aminobiphenyl.
Carcinogenesis 1989;10(6):1127-30.
1989: Tatematsu M; Katsuyama T; Mutai M; Asakawa E; Ito N
Pyloric gland phenotypic expression of gastric cancers developing in the rat fundic glandular stomach.
Carcinogenesis 1989;10(6):1033-9.
1989: Tatematsu M; Mutai M; Aoki T; de Camargo J L; Furihata C; Ito N
Proliferation kinetics of pepsinogen altered pyloric gland cells in rats treated with N-methyl-N'-nitro-N-nitrosoguanidine.
Carcinogenesis 1989;10(5):907-11.
1989: Thamavit W; Fukushima S; Kurata Y; Asamoto M; Ito N
Modification by sodium L-ascorbate, butylated hydroxytoluene, phenobarbital and pepleomycin of lesion development in a wide-spectrum initiation rat model.
Cancer letters 1989;45(2):93-101.
1989: Imaida K; Tatematsu M; Kato T; Tsuda H; Ito N
Advantages and limitations of stereological estimation of placental glutathione S-transferase-positive rat liver cell foci by computerized three-dimensional reconstruction.
Japanese journal of cancer research : Gann 1989;80(4):326-30.
1989: Ito N; Hagiwara A; Tamano S; Kagawa M; Shibata M; Kurata Y; Fukushima S
Lack of carcinogenicity of quercetin in F344/DuCrj rats.
Japanese journal of cancer research : Gann 1989;80(4):317-25.
1989: Shirai T; Nakamura A; Fukushima S; Takahashi S; Ogawa K; Ito N
Effects of age on multiple organ carcinogenesis induced by 3,2'-dimethyl-4-aminobiphenyl in rats, with particular reference to the prostate.
Japanese journal of cancer research : Gann 1989;80(4):312-6.
1989: Fukushima S; Asamoto M; Imaida K; el-Bolkainy M N; Tawfik H N; Ito N
Comparative study of urinary bladder carcinomas in Japanese and Egyptians.
Acta pathologica japonica 1989;39(3):176-9.
1989: Hasegawa R; Fukushima S; Hagiwara A; Masui T; Masuda A; Ito N
Long-term feeding study of N,N'-diphenyl-p-phenylenediamine in F344 rats.
Toxicology 1989;54(1):69-78.
1989: Shirai T; Fukushima S; Tagawa Y; Okumura M; Ito N
Cell proliferation induced by uracil-calculi and subsequent development of reversible papillomatosis in the rat urinary bladder.
Cancer research 1989;49(2):378-83.
1989: Ito N; Fukushima S; Hasegawa R
Bladder cancers. Their process of development and its modification.
Acta pathologica japonica 1989;39(1):1-14.
1989: Ito N; Hirose M
Antioxidants--carcinogenic and chemopreventive properties.
Advances in cancer research 1989;53():247-302.
1989: Ito N; Imaida K; Hasegawa R; Tsuda H
Rapid bioassay methods for carcinogens and modifiers of hepatocarcinogenesis.
Critical reviews in toxicology 1989;19(4):385-415.
1989: Ito N; Tatematsu M; Hasegawa R; Tsuda H
Medium-term bioassay system for detection of carcinogens and modifiers of hepatocarcinogenesis utilizing the GST-P positive liver cell focus as an endpoint marker.
Toxicologic pathology 1989;17(4 Pt 1):630-41.
1989: Tsuda H; Inoue T; Asamoto M; Fukushima S; Ito N; Okamura T; Ohtaguro K; Washida H; Satoh K; Amelizad Z
Comparison of enzyme phenotypes in human bladder tumours and experimentally induced hyperplastic and neoplastic lesions of the rat urinary bladder. A combined histochemical and immunohistochemical approach.
Virchows Archiv. B, Cell pathology including molecular pathology 1989;56(5):307-16.
1988: Imaida K; Fukushima S; Inoue K; Masui T; Hirose M; Ito N
Modifying effects of concomitant treatment with butylated hydroxyanisole or butylated hydroxytoluene on N,N-dibutylnitrosamine-induced liver, forestomach and urinary bladder carcinogenesis in F344 male rats.
Cancer letters 1988;43(3):167-72.
1988: Hirose M; Hagiwara A; Inoue K; Ito N; Kaneko H; Saito K; Matsunaga H; Isobe N; Yoshitake A; Miyamoto J
Metabolism of 2- and 3-tert-butyl-4-hydroxyanisole in the rat (III): Metabolites in the urine and feces.
Toxicology 1988;53(1):33-43.
1988: Shirai T; Tagawa Y; Taguchi O; Ikawa E; Mutai M; Fukushima S; Ito N
Low tumorigenic response to 3,2'-dimethyl-4-aminobiphenyl administration in the prostate of rats castrated at birth.
Japanese journal of cancer research : Gann 1988;79(12):1293-6.
1988: Hirose M; Fukushima S; Kurata Y; Tsuda H; Tatematsu M; Ito N
Modification of N-methyl-N'-nitro-N-nitrosoguanidine-induced forestomach and glandular stomach carcinogenesis by phenolic antioxidants in rats.
Cancer research 1988;48(18):5310-5.
1988: Ito N; Shirai T; Tagawa Y; Nakamura A; Fukushima S
Variation in tumor yield in the prostate and other target organs of the rat in response to varied dosage and duration of administration of 3,2'-dimethyl-4-aminobiphenyl.
Cancer research 1988;48(16):4629-32.
1988: Thamavit W; Moore M A; Hiasa Y; Ito N
Generation of high yields of Syrian hamster cholangiocellular carcinomas and hepatocellular nodules by combined nitrite and aminopyrine administration and Opisthorchis viverrini infection.
Japanese journal of cancer research : Gann 1988;79(8):909-16.
1988: Masui T; Fukushima S; Katoh F; Yamasaki H; Ito N
Effects of sodium L-ascorbate, uracil, butylated hydroxyanisole and extracellular pH on junctional intercellular communication of BALB/c 3T3 cells.
Carcinogenesis 1988;9(7):1143-6.
1988: Fukushima S; Tamano S; Shibata M A; Kurata Y; Hirose M; Ito N
The role of urinary pH and sodium ion concentration in the promotion stage of two-stage carcinogenesis of the rat urinary bladder.
Carcinogenesis 1988;9(7):1203-6.
1988: Tsuda H; Asamoto M; Kagawa M; Uwagawa S; Inoue K; Inui M; Ito N
Positive influence of dietary deoxycholic acid on development of pre-neoplastic lesions initiated by N-methyl-N-nitrosourea in rat liver.
Carcinogenesis 1988;9(6):1103-5.
1988: Tsuda H; Asamoto M; Ogiso T; Inoue T; Ito N; Nagao M
Dose-dependent induction of liver and thyroid neoplastic lesions by short-term administration of 2-amino-3-methylimidazo[4,5-f]quinoline combined with partial hepatectomy followed by phenobarbital or low dose 3'-methyl-4-dimethylaminoazobenzene promotion.
Japanese journal of cancer research : Gann 1988;79(6):691-7.
1988: Thamavit W; Moore M A; Hiasa Y; Ito N
Enhancement of DHPN induced hepatocellular, cholangiocellular and pancreatic carcinogenesis by Opisthorchis viverrini infestation in Syrian golden hamsters.
Carcinogenesis 1988;9(6):1095-8.
1988: Ito N; Imaida K; de Camargo J L; Takahashi S; Asamoto M; Tsuda H
A new medium-term bioassay system for detection of environmental carcinogens using diethylnitrosamine-initiated rat liver followed by D-galactosamine treatment and partial hepatectomy.
Japanese journal of cancer research : Gann 1988;79(5):573-5.
1988: Shirai T; Masuda A; Imaida K; Ogiso T; Ito N
Effects of phenobarbital and carbazole on carcinogenesis of the lung, thyroid, kidney, and bladder of rats pretreated with N-bis(2-hydroxypropyl)nitrosamine.
Japanese journal of cancer research : Gann 1988;79(4):460-5.
1988: Nakanowatari J; Fukushima S; Imaida K; Ito N; Nagase S
Strain differences in N-butyl-N-(4-hydroxybutyl)nitrosamine bladder carcinogenesis in rats.
Japanese journal of cancer research : Gann 1988;79(4):453-9.
1988: Ito N; Imaida K; Tsuda H; Shibata M; Aoki T; de Camargo J L; Fukushima S
Wide-spectrum initiation models: possible applications to medium-term multiple organ bioassays for carcinogenesis modifiers.
Japanese journal of cancer research : Gann 1988;79(4):413-7.
1988: Tsuda H; Moore M A; Asamoto M; Inoue T; Ito N; Satoh K; Ichihara A; Nakamura T; Amelizad Z; Oesch F
Effect of modifying agents on the phenotypic expression of cytochrome P-450, glutathione S-transferase molecular forms, microsomal epoxide hydrolase, glucose-6-phosphate dehydrogenase and gamma-glutamyltranspeptidase in rat liver preneoplastic lesions.
Carcinogenesis 1988;9(4):547-54.
1988: Tatematsu M; Aoki T; Inoue T; Mutai M; Furihata C; Ito N
Coefficient induction of pepsinogen 1-decreased pyloric glands and gastric cancers in five different strains of rats treated with N-methyl-N'-nitro-N-nitrosoguanidine.
Carcinogenesis 1988;9(3):495-8.
1988: Ito N; Tsuda H; Tatematsu M; Inoue T; Tagawa Y; Aoki T; Uwagawa S; Kagawa M; Ogiso T; Masui T
Enhancing effect of various hepatocarcinogens on induction of preneoplastic glutathione S-transferase placental form positive foci in rats--an approach for a new medium-term bioassay system.
Carcinogenesis 1988;9(3):387-94.
1988: Shirai T; Yamamoto K; Adachi T; Imaida K; Masui T; Ito N
Condyloma acuminatum of the bladder in two autopsy cases.
Acta pathologica japonica 1988;38(3):399-405.
1988: Tatematsu M; Aoki T; Kagawa M; Mera Y; Ito N
Reciprocal relationship between development of glutathione S-transferase positive liver foci and proliferation of surrounding hepatocytes in rats.
Carcinogenesis 1988;9(2):221-5.
1988: Tatematsu M; Mera Y; Inoue T; Satoh K; Sato K; Ito N
Stable phenotypic expression of glutathione S-transferase placental type and unstable phenotypic expression of gamma-glutamyltransferase in rat liver preneoplastic and neoplastic lesions.
Carcinogenesis 1988;9(2):215-20.
1988: Hirose M; Masuda A; Fukushima S; Ito N
Effects of subsequent antioxidant treatment on 7,12-dimethylbenz[a]anthracene-initiated carcinogenesis of the mammary gland, ear duct and forestomach in Sprague-Dawley rats.
Carcinogenesis 1988;9(1):101-4.
1988: Tamano S; Hagiwara A; Shibata M A; Kurata Y; Fukushima S; Ito N
Spontaneous tumors in aging (C57BL/6N x C3H/HeN)F1 (B6C3F1) mice.
Toxicologic pathology 1988;16(3):321-6.
1988: Tatematsu M; Ichinose M; Miki K; Tatematsu K; Kishikawa H; Ito N
Gastric phenotypic expression in human gallbladder cancers revealed by pepsinogen immunohistochemistry and mucin histochemistry.
Virchows Archiv. A, Pathological anatomy and histopathology 1988;413(1):25-32.
1987: Shirai T; Tagawa Y; Fukushima S; Imaida K; Ito N
Strong promoting activity of reversible uracil-induced urolithiasis on urinary bladder carcinogenesis in rats initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine.
Cancer research 1987;47(24 Pt 1):6726-30.
1987: Hirose M; Masuda A; Tsuda H; Uwagawa S; Ito N
Enhancement of BHA-induced proliferative rat forestomach lesion development by simultaneous treatment with other antioxidants.
Carcinogenesis 1987;8(11):1731-5.
1987: Hirose M; Kurata Y; Tsuda H; Fukushima S; Ito N
Catechol strongly enhances rat stomach carcinogenesis: a possible new environmental stomach carcinogen.
Japanese journal of cancer research : Gann 1987;78(11):1144-9.
1987: Tsuda H; Masui T; Ikawa E; Imaida K; Ito N
Compared promoting potential of D-galactosamine, carbon tetrachloride and partial hepatectomy in rapid induction of preneoplastic liver lesions in the rat.
Cancer letters 1987;37(2):163-71.
1987: Shirai T; Fukushima S; Hirose M; Ohshima M; Ito N
Epithelial lesions of the urinary bladder in three hundred and thirteen autopsy cases.
Japanese journal of cancer research : Gann 1987;78(10):1073-80.
1987: Ito N; Hirose M
The role of antioxidants in chemical carcinogenesis.
Japanese journal of cancer research : Gann 1987;78(10):1011-26.
1987: Hirose M; Inoue T; Masuda A; Tsuda H; Ito N
Effects of simultaneous treatment with various chemicals on BHA-induced development of rat forestomach hyperplasia--complete inhibition by diethylmaleate in a 5-week feeding study.
Carcinogenesis 1987;8(10):1555-8.
1987: Tatematsu M; Fukushima S; Aoki T; Mera Y; Inoue T; Ito N
Patterns of epithelial proliferation revealed by continuous administration of bromodeoxyuridine during urinary bladder carcinogenesis in rats.
Japanese journal of cancer research : Gann 1987;78(9):879-82.
1987: Tsuda H; Moore M A; Asamoto M; Inoue T; Fukushima S; Ito N; Satoh K; Amelizad Z; Oesch F
Immunohistochemically demonstrated altered expression of cytochrome P-450 molecular forms and epoxide hydrolase in N-ethyl-N-hydroxyethylnitrosamine-induced rat kidney and liver lesions.
Carcinogenesis 1987;8(5):711-7.
1987: Shibata M; Kurata Y; Tamano S; Ogiso T; Fukushima S; Ito N
13-week subchronic toxicity study with morpholine oleic acid salt administered to B6C3F1 mice.
Journal of toxicology and environmental health 1987;22(2):187-94.
1987: Moore M A; Tsuda H; Hacker H J; Sato K; Bannasch P; Ito N
Altered enzyme expression in propylnitrosamine-induced Syrian hamster lung lesions.
Virchows Archiv. B, Cell pathology including molecular pathology 1987;53(5):272-8.

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