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Shinya Ito

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TOP 3
Shinya Ito
System, crowd, and communal innovation: can the monks solve the elephant?
Alex Man Lai Wu; Mingdong Yang; Charles V Clevenger; Pooja Dalvi; Patricia A Harper; Xiaoli Lu; Jason Matthews; David S Riddick; Douglas Ross; Shinya Ito
Induction of multidrug resistance transporter ABCG2 by prolactin in human breast cancer cells.
Shinya Ito; Hidefumi Nakamura; Tohru Kobayashi
Pediatric pharmacology in Japan.

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All Publications

2013: Shinya Ito
System, crowd, and communal innovation: can the monks solve the elephant?
Clinical pharmacology and therapeutics 2013;93(5):369-71.
2013: Alex Man Lai Wu; Mingdong Yang; Charles V Clevenger; Pooja Dalvi; Patricia A Harper; Xiaoli Lu; Jason Matthews; David S Riddick; Douglas Ross; Shinya Ito
Induction of multidrug resistance transporter ABCG2 by prolactin in human breast cancer cells.
Molecular pharmacology 2013;83(2):377-88.
2012: Shinya Ito; Hidefumi Nakamura; Tohru Kobayashi
Pediatric pharmacology in Japan.
Paediatric drugs 2012;14(4):247-9.
2012: Gideon Koren; Irena Nulman; Katarina Aleksa; Adrienne Einarson; Joey Gareri; Shinya Ito
Essay for the 2011 CIHR/CMAJ award: Motherisk--caring for mothers, protecting the unborn.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 2012;184(2):E155-7.
2011: Shinya Ito
Pharmacokinetics 101.
Paediatrics & child health 2011;16(9):535-6.
2011: Shinya Ito
Placebo in clinical trials.
Clinical pharmacology and therapeutics 2011;90(5):637-9.
2011: Yaron Finkelstein; Patrick Acuna; Mathew George; Shinya Ito; Gideon Koren; Elena Pope; Michael W Shannon; Neil H Shear; Gordon S Soon; Facundo Garcia-Bournissen
Recurrence and outcomes of Stevens-Johnson syndrome and toxic epidermal necrolysis in children.
Pediatrics 2011;128(4):723-8.
2011: Shinya Ito
A new dimension of clinical pharmacology: induced pluripotent stem cells.
Clinical pharmacology and therapeutics 2011;89(5):629-32.
2010: K P Tan; G A Wood; M Yang; Shinya Ito
Participation of nuclear factor (erythroid 2-related), factor 2 in ameliorating lithocholic acid-induced cholestatic liver injury in mice.
British journal of pharmacology 2010;161(5):1111-21.
2010: Kah Poh Tan; Bernice Wang; Mingdong Yang; Paul C Boutros; Jane Macaulay; Haibo Xu; Andrew I Chuang; Kazuhiro Kosuge; Mika Yamamoto; Shinichiro Takahashi; Alex M L Wu; Douglas Ross; Patricia A Harper; Shinya Ito
Aryl hydrocarbon receptor is a transcriptional activator of the human breast cancer resistance protein (BCRP/ABCG2).
Molecular pharmacology 2010;78(2):175-85.
2010: Andrew I Chuang; Shinya Ito
Ambient tonicity and intestinal cytochrome CYP3A.
Expert opinion on drug metabolism & toxicology 2010;6(8):883-93.
2010: Patrina Gunness; Katarina Aleksa; Kazuhiro Kosuge; Shinya Ito; Gideon Koren
Comparison of the novel HK-2 human renal proximal tubular cell line with the standard LLC-PK1 cell line in studying drug-induced nephrotoxicity.
Canadian journal of physiology and pharmacology 2010;88(4):448-55.
2010: Facundo Garcia-Bournissen; Jaime Altcheh; Alice Panchaud; Shinya Ito
Is use of nifurtimox for the treatment of Chagas disease compatible with breast feeding? A population pharmacokinetics analysis.
Archives of disease in childhood 2010;95(3):224-8.
2010: Candace Y W Lee; Savithiri Ratnapalan; Margaret Thompson; Paul C Nathan; Jordan Closs; Amy French; Angela Punnett; Facundo Garcia-Bournissen; Shinya Ito; Gideon Koren
Unusual reactions to 5-HT3 receptor antagonists in a child with rhabdomyosarcoma.
The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique 2010;17(1):e1-4.
2009: Miho Inoue; Christopher A Caldarone; Helena Frndova; Peter N Cox; Shinya Ito; Anna Taddio; Anne-Marie Guerguerian
Safety and efficacy of ketorolac in children after cardiac surgery.
Intensive care medicine 2009;35(9):1584-92.
2009: A C Lau; Trang T Duong; Shinya Ito; G J Wilson; Rae S M Yeung
Inhibition of matrix metalloproteinase-9 activity improves coronary outcome in an animal model of Kawasaki disease.
Clinical and experimental immunology 2009;157(2):300-9.
2009: Andrew C Lau; Trang T Duong; Shinya Ito; Rae S M Yeung
Intravenous immunoglobulin and salicylate differentially modulate pathogenic processes leading to vascular damage in a model of Kawasaki disease.
Arthritis and rheumatism 2009;60(7):2131-41.
2009: Shirley Levy; Ibrahim Fayez; Nobuko Taguchi; Jung-Yeol Han; Jennifer Aiello; Doreen Matsui; Myla Moretti; Gideon Koren; Shinya Ito
Pregnancy outcome following in utero exposure to bisphosphonates.
Bone 2009;44(3):428-30.
2009: Violette M G J Gijsen; Saskia N de Wildt; Shinya Ito
Probability of rash related to gabapentin therapy in a child.
The Annals of pharmacotherapy 2009;43(2):387-9.
2009: Shinya Ito
Breast cancer risk and history of being breast-fed.
Epidemiology (Cambridge, Mass.) 2009;20(1):155.
2009: Shinya Ito
Clinical investigation in pediatrics: challenges and opportunities in Toronto, Canada.
Paediatric drugs 2009;11(1):67-8.
2009: Saskia N de Wildt; Shinya Ito; Gideon Koren
Challenges for drug studies in children: CYP3A phenotyping as example.
Drug discovery today 2009;14(1-2):6-15.
2008: Kah Poh Tan; Kazuhiro Kosuge; Mingdong Yang; Shinya Ito
NRF2 as a determinant of cellular resistance in retinoic acid cytotoxicity.
Free radical biology & medicine 2008;45(12):1663-73.
2008: Toshihiro Tanaka; Myla E Moretti; Zul Verjee; Michael Shupak; Katalin E Ivanyi; Shinya Ito
A pitfall of measuring lithium levels in neonates.
Therapeutic drug monitoring 2008;30(6):752-4.
2008: Eran Kozer; Zina Levichek; Noriko Hoshino; Bhushan Kapur; John Leombruno; Nobuko Taguchi; Facundo Garcia-Bournissen; Gideon Koren; Shinya Ito
The effect of amitriptyline, gabapentin, and carbamazepine on morphine-induced hypercarbia in rabbits.
Anesthesia and analgesia 2008;107(4):1216-22.
2008: Nobuko Taguchi; Evelyn T Rubin; Akiko Hosokawa; Jacquelyn Choi; Angela Yating Ying; Myla E Moretti; Gideon Koren; Shinya Ito
Prenatal exposure to HMG-CoA reductase inhibitors: effects on fetal and neonatal outcomes.
Reproductive toxicology (Elmsford, N.Y.) 2008;26(2):175-7.
2008: Andrew C Lau; Trang T Duong; Shinya Ito; Rae S M Yeung
Matrix metalloproteinase 9 activity leads to elastin breakdown in an animal model of Kawasaki disease.
Arthritis and rheumatism 2008;58(3):854-63.
2008: María Fabiana De Rosa; Cameron Ackerley; Bernice Wang; Shinya Ito; David M Clarke; Clifford A Lingwood
Inhibition of multidrug resistance by adamantylgb3, a globotriaosylceramide analog.
The Journal of biological chemistry 2008;283(8):4501-11.
2007: Kah Poh Tan; Mingdong Yang; Shinya Ito
Activation of nuclear factor (erythroid-2 like) factor 2 by toxic bile acids provokes adaptive defense responses to enhance cell survival at the emergence of oxidative stress.
Molecular pharmacology 2007;72(5):1380-90.
2007: Kazuhiro Kosuge; Andrew I Chuang; Satoko Uematsu; Kah Poh Tan; Kyoichi Ohashi; Ben C B Ko; Shinya Ito
Discovery of osmosensitive transcriptional regulation of human cytochrome P450 3As by the tonicity-responsive enhancer binding protein (nuclear factor of activated T cells 5).
Molecular pharmacology 2007;72(4):826-37.
2006: Myla E Moretti; Zul Verjee; Shinya Ito; Gideon Koren
Breast-feeding during maternal use of azathioprine.
The Annals of pharmacotherapy 2006;40(12):2269-72.
2006: Raanan Cohen-Kerem; Savithiri Ratnapalan; Josephine Djulus; Xu Duan; Rahul V Chandra; Shinya Ito
The attitude of physicians toward cold remedies for upper respiratory infection in infants and children: a questionnaire survey.
Clinical pediatrics 2006;45(9):828-34.
2006: Katarina Aleksa; Shinya Ito; Gideon Koren
Enantioselective metabolism of ifosfamide by the kidney.
Chirality 2006;18(6):398-405.
2006: Lisa A Houghton; Kelly L Sherwood; Robert J Pawlosky; Shinya Ito; Deborah L O'Connor
[6S]-5-Methyltetrahydrofolate is at least as effective as folic acid in preventing a decline in blood folate concentrations during lactation.
The American journal of clinical nutrition 2006;83(4):842-50.
2006: Bruce Kwok; Ariko Yamauchi; Ratheishan Rajesan; Lillian Chan; Upinder Dhillon; Wen Gao; Haibo Xu; Bernice Wang; Shinichiro Takahashi; John Semple; Ikumi Tamai; Jun-Ichi Nezu; Akira Tsuji; Patricia Harper; Shinya Ito
Carnitine/xenobiotics transporters in the human mammary gland epithelia, MCF12A.
American journal of physiology. Regulatory, integrative and comparative physiology 2006;290(3):R793-802.
2005: Haibo Xu; Ratheishan Rajesan; Patricia Harper; Richard B Kim; Bo Lonnerdal; Mingdong Yang; Satoko Uematsu; Janine Hutson; Jo Watson-MacDonell; Shinya Ito
Induction of cytochrome P450 1A by cow milk-based formula: a comparative study between human milk and formula.
British journal of pharmacology 2005;146(2):296-305.
2005: Katarina Aleksa; Douglas G Matsell; Kris Krausz; Harry V Gelboin; Shinya Ito; Gideon Koren
Cytochrome P450 3A and 2B6 in the developing kidney: implications for ifosfamide nephrotoxicity.
Pediatric nephrology (Berlin, Germany) 2005;20(7):872-85.
2005: Katarina Aleksa; Naomi Halachmi; Shinya Ito; Gideon Koren
A tubule cell model for ifosfamide nephrotoxicity.
Canadian journal of physiology and pharmacology 2005;83(6):499-508.
2005: Evgueni Ivakine; Casey J Fox; Andrew D Paterson; Steven M Mortin-Toth; Angelo Canty; David S Walton; Katarina Aleksa; Shinya Ito; Jayne S Danska
Sex-specific effect of insulin-dependent diabetes 4 on regulation of diabetes pathogenesis in the nonobese diabetic mouse.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(11):7129-40.
2004: Katarina Aleksa; Naomi Halachmi; Shinya Ito; Gideon Koren
Renal ontogeny of ifosfamide nephrotoxicity.
The Journal of laboratory and clinical medicine 2004;144(6):285-93.
2004: D Oren; Irena Nulman; M Makhija; Shinya Ito; Gideon Koren
Using corticosteroids during pregnancy. Are topical, inhaled, or systemic agents associated with risk?
Canadian family physician Médecin de famille canadien 2004;50():1083-5.
2004: Katarina Aleksa; Shinya Ito; Gideon Koren
Renal-tubule metabolism of ifosfamide to the nephrotoxic chloroacetaldehyde: pharmacokinetic modeling for estimation of intracellular levels.
The Journal of laboratory and clinical medicine 2004;143(3):159-62.
2004: Evelyn T Rubin; Amy Lee; Shinya Ito
When breastfeeding mothers need CNS-acting drugs.
The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique 2004;11(2):e257-66.
2004: Savithiri Ratnapalan; Shinya Ito
Pediatric resident education and needs assessment in clinical pharmacology.
The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique 2004;11(1):e150-5.
2004: Amy Lee; Juliana Woo; Shinya Ito
Frequency of infant adverse events that are associated with citalopram use during breast-feeding.
American journal of obstetrics and gynecology 2004;190(1):218-21.
2003: Shinya Ito
Is CFTR dysfunction in cystic fibrosis compensated by MRPs?
Pediatric research 2003;54(5):625-6.
2003: Line Alleslev Larsen; Shinya Ito; Gideon Koren
Prediction of milk/plasma concentration ratio of drugs.
The Annals of pharmacotherapy 2003;37(9):1299-306.
2003: Amy Lee; Ravinder Minhas; Noriko Matsuda; Michael Lam; Shinya Ito
The safety of St. John's wort (Hypericum perforatum) during breastfeeding.
The Journal of clinical psychiatry 2003;64(8):966-8.
2003: Cindy Woodland; Gideon Koren; irving william wainer; Gerry Batist; Shinya Ito
Verapamil metabolites: potential P-glycoprotein-mediated multidrug resistance reversal agents.
Canadian journal of physiology and pharmacology 2003;81(8):800-5.
2003: Cindy Woodland; Gideon Koren; Shinya Ito
From bench to bedside: utilization of an in vitro model to predict potential drug-drug interactions in the kidney: the digoxin-mifepristone example.
Journal of clinical pharmacology 2003;43(7):743-50.
2003: Myla E Moretti; Michael Sgro; David Johnson; Reg Sauve; Mary J Woolgar; Anna Taddio; Zul Verjee; Esther Giesbrecht; Gideon Koren; Shinya Ito
Cyclosporine excretion into breast milk.
Transplantation 2003;75(12):2144-6.
2003: Akiko Hosokawa; Benjamin Bar-Oz; Shinya Ito
Use of lipid-lowering agents (statins) during pregnancy.
Canadian family physician Médecin de famille canadien 2003;49():747-9.
2003: Myla E Moretti; Gideon Koren; Zul Verjee; Shinya Ito
Monitoring lithium in breast milk: an individualized approach for breast-feeding mothers.
Therapeutic drug monitoring 2003;25(3):364-6.
2003: Shinya Ito; Jane Alcorn
Xenobiotic transporter expression and function in the human mammary gland.
Advanced drug delivery reviews 2003;55(5):653-65.
2003: Shinya Ito; Amy Lee
Drug excretion into breast milk--overview.
Advanced drug delivery reviews 2003;55(5):617-27.
2002: Adriana Moldovan Costei; Eran Kozer; Tommy Ho; Shinya Ito; Gideon Koren
Perinatal outcome following third trimester exposure to paroxetine.
Archives of pediatrics & adolescent medicine 2002;156(11):1129-32.
2001: Shinya Ito
Transplacental treatment of fetal tachycardia: implications of drug transporting proteins in placenta.
Seminars in perinatology 2001;25(3):196-201.
2000: Cindy Woodland; Shinya Ito; C P Granvil; irving william wainer; Julia Klein; Gideon Koren
Evidence of renal metabolism of ifosfamide to nephrotoxic metabolites.
Life sciences 2000;68(1):109-17.
2000: C R Tunzi; Patricia A Harper; Benjamin Bar-Oz; E V Valore; J L Semple; Jo Watson-MacDonell; T Ganz; Shinya Ito
Beta-defensin expression in human mammary gland epithelia.
Pediatric research 2000;48(1):30-5.
2000: A Lee; Myla E Moretti; A Collantes; D Chong; Paolo Mazzotta; Gideon Koren; S S Merchant; Shinya Ito
Choice of breastfeeding and physicians' advice: a cohort study of women receiving propylthiouracil.
Pediatrics 2000;106(1 Pt 1):27-30.
2000: P Lala; Shinya Ito; Clifford A Lingwood
Retroviral transfection of Madin-Darby canine kidney cells with human MDR1 results in a major increase in globotriaosylceramide and 10(5)- to 10(6)-fold increased cell sensitivity to verocytotoxin. Role of p-glycoprotein in glycolipid synthesis.
The Journal of biological chemistry 2000;275(9):6246-51.
1999: Shinya Ito
Drug secretion systems in renal tubular cells: functional models and molecular identity.
Pediatric nephrology (Berlin, Germany) 1999;13(9):980-8.
1999: JA Stiskal; Shinya Ito; D W Cox; AT Shennan; KK O'Brien; Edmond N Kelly; T B Longley; Marlene Rabinovitch; Michael S Dunn
Functional and antigenic concentrations of alpha-1-proteinase inhibitor after administration for the prevention of chronic lung disease of prematurity.
Biology of the neonate 1999;76(3):134-43.
1999: Shinya Ito; Cindy Woodland; Balázs Sarkadi; G Hockmann; S E Walker; Gideon Koren
Modeling of P-glycoprotein-involved epithelial drug transport in MDCK cells.
The American journal of physiology 1999;277(1 Pt 2):F84-96.
1999: Gideon Koren; M Moretti; Shinya Ito
Continuing drug therapy while breastfeeding. Part 2. Common misconceptions of physicians.
Canadian family physician Médecin de famille canadien 1999;45():1173-5.
1999: Ronen Loebstein; Gardana Atanackovic; R Bishai; Jacob Wolpin; Sohail Khattak; G Hashemi; M Gobrial; Sylvain Baruchel; Shinya Ito; Gideon Koren
Risk factors for long-term outcome of ifosfamide-induced nephrotoxicity in children.
Journal of clinical pharmacology 1999;39(5):454-61.
1998: Shinya Ito; Robert M Gow; Zul Verjee; Esther Giesbrecht; H Dodo; Robert M Freedom; GR Tonn; J E Axelson; E Zalzstein; H C Rosenberg; Gideon Koren
Intravenous and oral propafenone for treatment of tachycardia in infants and children: pharmacokinetics and clinical response.
Journal of clinical pharmacology 1998;38(6):496-501.
1998: Gideon Koren; Cindy Woodland; Shinya Ito
Toxic digoxin-drug interactions: the major role of renal P-glycoprotein.
Veterinary and human toxicology 1998;40(1):45-6.
1998: Shinya Ito; S Weitzman; Julia Klein; M Greenberg; R Lau; G Atanakovic; Gideon Koren
Lack of cisplatin-ranitidine kinetic interactions: in vivo study in children, and in vitro study using dog renal brush border membrane vesicles.
Life sciences 1998;62(25):PL387-92.
1998: JA Stiskal; Michael S Dunn; AT Shennan; KK O'Brien; Edmond N Kelly; Robert Koppel; D W Cox; Shinya Ito; S L Chappel; Marlene Rabinovitch
alpha1-Proteinase inhibitor therapy for the prevention of chronic lung disease of prematurity: a randomized, controlled trial.
Pediatrics 1998;101(1 Pt 1):89-94.
1997: Cindy Woodland; Zul Verjee; Esther Giesbrecht; Gideon Koren; Shinya Ito
The digoxin-propafenone interaction: characterization of a mechanism using renal tubular cell monolayers.
The Journal of pharmacology and experimental therapeutics 1997;283(1):39-45.
1997: B Bailey; Shinya Ito
Breast-feeding and maternal drug use.
Pediatric clinics of North America 1997;44(1):41-54.
1994: Shinya Ito; L Magee; Jeffrey F Smallhorn
Drug therapy for fetal arrhythmias.
Clinics in perinatology 1994;21(3):543-72.
1994: Shinya Ito; Gideon Koren
A novel index for expressing exposure of the infant to drugs in breast milk.
British journal of clinical pharmacology 1994;38(2):99-102.
1993: Shinya Ito; C Woodland; Patricia A Harper; Gideon Koren
The mechanism of the verapamil-digoxin interaction in renal tubular cells (LLC-PK1).
Life sciences 1993;53(24):PL399-403.
1993: Shinya Ito; C Woodland; Patricia A Harper; Gideon Koren
P-glycoprotein-mediated renal tubular secretion of digoxin: the toxicological significance of the urine-blood barrier model.
Life sciences 1993;53(2):PL25-31.
1993: Shinya Ito; Gideon Koren; Patricia A Harper; M Silverman
Energy-dependent transport of digoxin across renal tubular cell monolayers (LLC-PK1).
Canadian journal of physiology and pharmacology 1993;71(1):40-7.
1992: D Matsui; C Hermann; M Braudo; Shinya Ito; N Olivieri; Gideon Koren
Clinical use of the Medication Event Monitoring System: a new window into pediatric compliance.
Clinical pharmacology and therapeutics 1992;52(1):102-3.
1992: Shinya Ito; Gideon Koren; Patricia A Harper
Handling of digoxin and ouabain by renal tubular cells (LLC-PK1).
The Journal of pharmacology and experimental therapeutics 1992;262(1):109-13.
1990: Shinya Ito; Patricia A Harper; Gideon Koren
Renal tubular cell handling of digoxin and ouabain--in vitro study using LLC-PK1 cell lines.
Toxicology letters 1990;53(1-2):189-91.