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Magnus Axelson

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Miguel Lemaire; Eline Menu; Anders Österborg; Ben Van Camp; Els Van Valckenborgh; Prasoon Agarwal; Peter Atadja; Magnus Axelson; Elke De Bruyne; Charlotte Fristedt; Helena Jernberg-Wiklund; Olle Larsson; Karin Vanderkerken
The HDAC inhibitor LBH589 enhances the antimyeloma effects of the IGF-1RTK inhibitor picropodophyllin.
Xiaoying Feng; Olle Larsson; Yingbo Lin; Eiman Aleem; Magnus Axelson; Thomas Strömberg
Multiple antitumor effects of picropodophyllin in colon carcinoma cell lines: clinical implications.
Yuko Rönquist-Nii; Staffan Eksborg; Magnus Axelson; Johan Harmenberg; Michael Bergqvist; Simon Ekman; Olof Beck
Determination of picropodophyllin and its isomer podophyllotoxin in human serum samples with electrospray ionization of hexylamine adducts by liquid chromatography-tandem mass spectrometry.

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2012: Miguel Lemaire; Eline Menu; Anders Österborg; Ben Van Camp; Els Van Valckenborgh; Prasoon Agarwal; Peter Atadja; Magnus Axelson; Elke De Bruyne; Charlotte Fristedt; Helena Jernberg-Wiklund; Olle Larsson; Karin Vanderkerken
The HDAC inhibitor LBH589 enhances the antimyeloma effects of the IGF-1RTK inhibitor picropodophyllin.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(8):2230-9.
2012: Xiaoying Feng; Olle Larsson; Yingbo Lin; Eiman Aleem; Magnus Axelson; Thomas Strömberg
Multiple antitumor effects of picropodophyllin in colon carcinoma cell lines: clinical implications.
International journal of oncology 2012;40(4):1251-8.
2011: Yuko Rönquist-Nii; Staffan Eksborg; Magnus Axelson; Johan Harmenberg; Michael Bergqvist; Simon Ekman; Olof Beck
Determination of picropodophyllin and its isomer podophyllotoxin in human serum samples with electrospray ionization of hexylamine adducts by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2011;879(5-6):326-34.
2011: Jamileh Hashemi; Claire Worrall; Daiana Vasilcanu; Mårten Fryknäs; Luqman Sulaiman; Mohsen Karimi; Wen-Hui Weng; Weng-Onn Lui; Christina Rudduck; Magnus Axelson; Helena Jernberg-Wiklund; Leonard Girnita; Olle Larsson; Catharina Larsson
Molecular characterization of acquired tolerance of tumor cells to picropodophyllin (PPP).
PloS one 2011;6(3):e14757.
2010: José Inzunza; Olle Danielsson; P G L Lalitkumar; Olle Larsson; Magnus Axelson; Virpi Töhönen; Kristina Gemzell Danielsson; Anneli Stavreus-Evers
Selective insulin-like growth factor-I antagonist inhibits mouse embryo development in a dose-dependent manner.
Fertility and sterility 2010;93(8):2621-6.
2010: Shucheng Yin; Ada Girnita; Thomas Strömberg; Zahidul Khan; Sandra Andersson; Huiyuan Zheng; Christer Ericsson; Magnus Axelson; Monica Nistér; Olle Larsson; Tomas J Ekström; Leonard Girnita
Targeting the insulin-like growth factor-1 receptor by picropodophyllin as a treatment option for glioblastoma.
Neuro-oncology 2010;12(1):19-27.
2009: Natalia Natalishvili; Magnus Axelson; Leonard Girnita; Olle Larsson; Daiana Vasilcanu
Aberrant intracellular IGF-1R beta-subunit makes receptor knockout cells (IGF1R-/-) susceptible to oncogenic transformation.
Experimental cell research 2009;315(8):1458-67.
2008: Mario A Economou; Jiangmei Wu; Daiana Vasilcanu; Linda Rosengren; Charlotta All-Ericsson; Ingeborg van der Ploeg; Eline Menu; Leonard Girnita; Magnus Axelson; Olle Larsson; Stefan Seregard; Anders Kvanta
Inhibition of VEGF secretion and experimental choroidal neovascularization by picropodophyllin (PPP), an inhibitor of the insulin-like growth factor-1 receptor.
Acta ophthalmologica 2008;86 Thesis 4():42-9.
2008: Mario A Economou; Sandra Andersson; Daiana Vasilcanu; Charlotta All-Ericsson; Eline Menu; Ada Girnita; Leonard Girnita; Magnus Axelson; Stefan Seregard; Olle Larsson
Oral picropodophyllin (PPP) is well tolerated in vivo and inhibits IGF-1R expression and growth of uveal melanoma.
Acta ophthalmologica 2008;86 Thesis 4():35-41.
2008: Ada Girnita; Charlotta All-Ericsson; Mario A Economou; Kristina Aström; Magnus Axelson; Stefan Seregard; Olle Larsson; Leonard Girnita
The insulin-like growth factor-I receptor inhibitor picropodophyllin causes tumor regression and attenuates mechanisms involved in invasion of uveal melanoma cells.
Acta ophthalmologica 2008;86 Thesis 4():26-34.
2008: Mario A Economou; Jiangmei Wu; Daiana Vasilcanu; Linda Rosengren; Charlotta All-Ericsson; Ingeborg van der Ploeg; Eline Menu; Leonard Girnita; Magnus Axelson; Olle Larsson; Stefan Seregard; Anders Kvanta
Inhibition of VEGF secretion and experimental choroidal neovascularization by picropodophyllin (PPP), an inhibitor of the insulin-like growth factor-1 receptor.
Investigative ophthalmology & visual science 2008;49(6):2620-6.
2008: Mario A Economou; Sandra Andersson; Daiana Vasilcanu; Charlotta All-Ericsson; Eline Menu; Ada Girnita; Leonard Girnita; Magnus Axelson; Stefan Seregard; Olle Larsson
Oral picropodophyllin (PPP) is well tolerated in vivo and inhibits IGF-1R expression and growth of uveal melanoma.
Investigative ophthalmology & visual science 2008;49(6):2337-42.
2008: Maria Törnkvist; Natalia Natalishvili; Yuntao Xie; Ada Girnita; Pádraig D'Arcy; Bertha Brodin; Magnus Axelson; Leonard Girnita
Differential roles of SS18-SSX fusion gene and insulin-like growth factor-1 receptor in synovial sarcoma cell growth.
Biochemical and biophysical research communications 2008;368(3):793-800.
2008: Hanna Pettersson; Lisa Holmberg; Magnus Axelson; Maria Norlin
CYP7B1-mediated metabolism of dehydroepiandrosterone and 5alpha-androstane-3beta,17beta-diol--potential role(s) for estrogen signaling.
The FEBS journal 2008;275(8):1778-89.
2008: Radu Vasilcanu; Daiana Vasilcanu; L Rosengren; N Natalishvili; B Sehat; S Yin; Ada Girnita; Magnus Axelson; Leonard Girnita; Olle Larsson
Picropodophyllin induces downregulation of the insulin-like growth factor 1 receptor: potential mechanistic involvement of Mdm2 and beta-arrestin1.
Oncogene 2008;27(11):1629-38.
2008: Radu Vasilcanu; Daiana Vasilcanu; Bita Sehat; Shucheng Yin; Ada Girnita; Magnus Axelson; Leonard Girnita
Insulin-like growth factor type-I receptor-dependent phosphorylation of extracellular signal-regulated kinase 1/2 but not Akt (protein kinase B) can be induced by picropodophyllin.
Molecular pharmacology 2008;73(3):930-9.
2007: Eline Menu; Helena Jernberg-Wiklund; Hendrik De Raeve; Evy De Leenheer; Les Coulton; Orla Gallagher; Els Van Valckenborgh; Olle Larsson; Magnus Axelson; Kenneth Nilsson; Ben Van Camp; Peter I Croucher; Karin Vanderkerken
Targeting the IGF-1R using picropodophyllin in the therapeutical 5T2MM mouse model of multiple myeloma: beneficial effects on tumor growth, angiogenesis, bone disease and survival.
International journal of cancer. Journal international du cancer 2007;121(8):1857-61.
2007: Anton Razuvaev; Bimma Henderson; Leonard Girnita; Olle Larsson; Magnus Axelson; Ulf Hedin; Joy Roy
The cyclolignan picropodophyllin attenuates intimal hyperplasia after rat carotid balloon injury by blocking insulin-like growth factor-1 receptor signaling.
Journal of vascular surgery 2007;46(1):108-15.
2006: Linda Rosengren; Daiana Vasilcanu; Radu Vasilcanu; Sandra Fickenscher; Bita Sehat; Nathalia Natalishvili; Sean Naughton; Shucheng Yin; Ada Girnita; Leonard Girnita; Magnus Axelson; Olle Larsson
IGF-1R tyrosine kinase expression and dependency in clones of IGF-1R knockout cells (R-).
Biochemical and biophysical research communications 2006;347(4):1059-66.
2006: Sergiu-Bogdan Catrina; Ileana Ruxandra Botusan; Anja Rantanen; Anca Irinel Catrina; Pawan Pyakurel; Octavian Savu; Magnus Axelson; Peter Biberfeld; Lorenz Poellinger; Kerstin Brismar
Hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha are expressed in kaposi sarcoma and modulated by insulin-like growth factor-I.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(15):4506-14.
2006: Daiana Vasilcanu; Wen-Hui Weng; Ada Girnita; Weng-Onn Lui; Radu Vasilcanu; Magnus Axelson; Olle Larsson; Catharina Larsson; Leonard Girnita
The insulin-like growth factor-1 receptor inhibitor PPP produces only very limited resistance in tumor cells exposed to long-term selection.
Oncogene 2006;25(22):3186-95.
2006: Ada Girnita; Charlotta All-Ericsson; Mario A Economou; Kristina Aström; Magnus Axelson; Stefan Seregard; Olle Larsson; Leonard Girnita
The insulin-like growth factor-I receptor inhibitor picropodophyllin causes tumor regression and attenuates mechanisms involved in invasion of uveal melanoma cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(4):1383-91.
2006: Thomas Strömberg; Simon Ekman; Leonard Girnita; Lina Dimberg; Olle Larsson; Magnus Axelson; Johan Lennartsson; Ulf Hellman; Kristina Carlson; Anders Osterborg; Karin Vanderkerken; Kenneth Nilsson; Helena Jernberg-Wiklund
IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G2/M-phase accumulation and apoptosis in multiple myeloma cells.
Blood 2006;107(2):669-78.
2006: Eline Menu; Helena Jernberg-Wiklund; Thomas Stromberg; Hendrik De Raeve; Leonard Girnita; Olle Larsson; Magnus Axelson; Kewal Asosingh; Kenneth Nilsson; Ben Van Camp; Karin Vanderkerken
Inhibiting the IGF-1 receptor tyrosine kinase with the cyclolignan PPP: an in vitro and in vivo study in the 5T33MM mouse model.
Blood 2006;107(2):655-60.
2005: Elfar Ulfarsson; Alexandra Karström; Shucheng Yin; Ada Girnita; Daiana Vasilcanu; Marja Thoren; Gunnar Kratz; Jan Hillman; Magnus Axelson; Olle Larsson; Leonard Girnita
Expression and growth dependency of the insulin-like growth factor I receptor in craniopharyngioma cells: a novel therapeutic approach.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(13):4674-80.
2005: Sergiu-Bogdan Catrina; Moira S Lewitt; Charles Massambu; Anica Dricu; J Grünler; Magnus Axelson; Peter Biberfeld; Kerstin Brismar
Insulin-like growth factor-I receptor activity is essential for Kaposi's sarcoma growth and survival.
British journal of cancer 2005;92(8):1467-74.
2004: Daiana Vasilcanu; Ada Girnita; Leonard Girnita; Radu Vasilcanu; Magnus Axelson; Olle Larsson
The cyclolignan PPP induces activation loop-specific inhibition of tyrosine phosphorylation of the insulin-like growth factor-1 receptor. Link to the phosphatidyl inositol-3 kinase/Akt apoptotic pathway.
Oncogene 2004;23(47):7854-62.
2004: Ada Girnita; Leonard Girnita; Fabrizio del Prete; Armando Bartolazzi; Olle Larsson; Magnus Axelson
Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth.
Cancer research 2004;64(1):236-42.