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Hideji Itokawa
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66
Takeya, Koichi
9
Hitotsuyanagi, Yukio
9
Morita, Hiroshi
8
Shirota, Osamu
4
Choo, Chee Yan
4
Chan, Kit-Lam
3
Gonda, Akira
3
Iizuka, Toru
3
Morita, Hiroshi
3
Ozeki, A
3
Satake, Motoyoshi
3
Sekita, Setsuko
2
Pettit, George
2
Kamano, Yoshiaki
2
Kobayashi, Jun'ichi
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All Publications
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2006: Morita Hiroshi; Eda Michiko; Iizuka Toru; Hirasawa Yusuke; Sekiguchi Mitsuhiro; Yun Young Sook; Itokawa Hideji; Takeya Koichi
Structure of a new cyclic nonapeptide, segetalin F, and vasorelaxant activity of segetalins from Vaccaria segetalis.
Bioorganic & medicinal chemistry letters 2006;16(17):4458-61.
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2006: Morita Hiroshi; Iizuka Toru; Gonda Akira; Itokawa Hideji; Takeya Koichi
Cycloleonuripeptides E and F, cyclic nonapeptides from Leonurus heterophyllus.
Journal of natural products 2006;69(5):839-41.
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2005: Morita Hiroshi; Iizuka Toru; Choo Chee-Yan; Chan Kit-Lam; Itokawa Hideji; Takeya Koichi
Dichotomins J and K, vasodilator cyclic peptides from Stellaria dichotoma.
Journal of natural products 2005;68(11):1686-8.
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2005: Morita Hiroshi; Awang Khalijah; Hadi A Hamid A; Takeya Koichi; Itokawa Hideji; Kobayashi Jun'ichi
Conformational analysis of rhazinilam and three-dimensional quantitative structure-activity relationships of rhazinilam analogues.
Bioorganic & medicinal chemistry letters 2005;15(4):1045-50.
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2004: Shirota Osamu; Sekita Setsuko; Satake Motoyoshi; Morita Hiroshi; Takeya Koichi; Itokawa Hideji
Nine new isoxuxuarine-type triterpene dimers from Maytenus chuchuhuasca.
Chemistry & biodiversity 2004;1(9):1296-307.
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2004: Shirota Osamu; Sekita Setsuko; Satake Motoyoshi; Morita Hiroshi; Takeya Koichi; Itokawa Hideji
Two cangorosin A type triterpene dimers from Maytenus chuchuhuasca.
Chemical & pharmaceutical bulletin 2004;52(9):1148-50.
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2004: Shirota Osamu; Sekita Setsuko; Satake Motoyoshi; Morita Hiroshi; Takeya Koichi; Itokawa Hideji
Nine regioisomeric and stereoisomeric triterpene dimers from Maytenus chuchuhuasca.
Chemical & pharmaceutical bulletin 2004;52(6):739-46.
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2004: Hitotsuyanagi Yukio; Hasuda Tomoyo; Aihara Takayuki; Ishikawa Hiroshi; Yamaguchi Kentaro; Itokawa Hideji; Takeya Koichi
Synthesis of [Gly-1]RA-VII, [Gly-2]RA-VII, and [Gly-4]RA-VII. Glycine-containing analogues of RA-VII, an antitumor bicyclic hexapeptide from Rubia plants.
The Journal of organic chemistry 2004;69(5):1481-6.
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2003: Hitotsuyanagi Yukio; Sasaki Shin-Ichi; Matsumoto Yuji; Yamaguchi Kentaro; Itokawa Hideji; Takeya Koichi
Synthesis of [L-Ala-1]RA-VII, [D-Ala-2]RA-VII, and [D-Ala-4]RA-VII by epimerization of RA-VII, an antitumor bicyclic hexapeptide from Rubia plants, through oxazoles.
Journal of the American Chemical Society 2003;125(24):7284-90.
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2002: Kamano Yoshiaki; Yamashita Ayano; Nogawa Toshihiko; Morita Hiroshi; Takeya Koichi; Itokawa Hideji; Segawa Toshiaki; Yukita Ayako; Saito Kyoko; Katsuyama Mariko; Pettit George R
QSAR evaluation of the Ch'an Su and related bufadienolides against the colchicine-resistant primary liver carcinoma cell line PLC/PRF/5(1).
Journal of medicinal chemistry 2002;45(25):5440-7.
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2002: Ishida Junko; Ohtsu Hironori; Tachibana Yoko; Nakanishi Yuka; Bastow Kenneth F; Nagai Masahiro; Wang Hui-Kang; Itokawa Hideji; Lee Kuo-Hsiung
Antitumor agents. Part 214: synthesis and evaluation of curcumin analogues as cytotoxic agents.
Bioorganic & medicinal chemistry 2002;10(11):3481-7.
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2001: Hitotsuyanagi Y; Ozeki A; Itokawa H; de Mello Alves S; Takeya K
Cedronolactone E, a novel C(19) quassinoid from Simaba cedron.
Journal of natural products 2001;64(12):1583-4.
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2001: Matsumoto T; Shishido A; Morita H; Itokawa H; Takeya K
Cyclolinopeptides F-I, cyclic peptides from linseed.
Phytochemistry 2001;57(2):251-60.
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2001: Choo C Y; Chan K L; Takeya K; Itokawa H
Cytotoxic activity of Typhonium flagelliforme (Araceae).
Phytotherapy research : PTR 2001;15(3):260-2.
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2000: Haraguchi M; Mimaki Y; Motidome M; Morita H; Takeya K; Itokawa H; Yokosuka A; Sashida Y
Steroidal saponins from the leaves of Cestrum sendtenerianum.
Phytochemistry 2000;55(7):715-20.
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2000: Morita H; Sato Y; Chan K L; Choo C Y; Itokawa H; Takeya K; Kobayashi J
Samoquasine A, a benzoquinazoline alkaloid from the seeds of Annona squamosa.
Journal of natural products 2000;63(12):1707-8.
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2000: Hitotsuyanagi Y; Fukuyo M; Tsuda K; Kobayashi M; Ozeki A; Itokawa H; Takeya K
4-Aza-2,3-dehydro-4-deoxypodophyllotoxins: simple aza-podophyllotoxin analogues possessing potent cytotoxicity.
Bioorganic & medicinal chemistry letters 2000;10(4):315-7.
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1999: Itokawa H; Takeya K; Hitotsuyanagi Y; Morita H
[Antitumor compounds isolated from higher plants]
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 1999;119(8):529-83.
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1998: Chan K L; Choo C Y; Morita H; Itokawa H
High performance liquid chromatography in phytochemical analysis of Eurycoma longifolia.
Planta medica 1998;64(8):741-5.
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1998: Kamano Y; Kotake A; Hashima H; Inoue M; Morita H; Takeya K; Itokawa H; Nandachi N; Segawa T; Yukita A; Saitou K; Katsuyama M; Pettit G R
Structure-cytotoxic activity relationship for the toad poison bufadienolides.
Bioorganic & medicinal chemistry 1998;6(7):1103-15.
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1998: Ozeki A; Hitotsuyanagi Y; Hashimoto E; Itokawa H; Takeya K; de Mello Alves S
Cytotoxic quassinoids from Simaba cedron.
Journal of natural products 1998;61(6):776-80.
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1998: Morita H; Gonda A; Wei L; Yamamura Y; Wakabayashi H; Takeya K; Itokawa H
Four new taxoids from Taxus cuspidata var. nana.
Planta medica 1998;64(2):183-6.
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1998: Yun Y S; Shimizu K; Morita H; Takeya K; Itokawa H; Shirota O
Triterpenoid saponin from Vaccaria segetalis.
Phytochemistry 1998;47(1):143-4.
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1997: Morita H; Yun Y S; Takeya K; Itokawa H
Conformational preference for segetalins G and H, cyclic peptides with estrogen-like activity from seeds of Vaccaria segetalis.
Bioorganic & medicinal chemistry 1997;5(11):2063-7.
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1997: Hirobe C; Qiao Z S; Takeya K; Itokawa H
Cytotoxic flavonoids from Vitex agnus-castus.
Phytochemistry 1997;46(3):521-4.
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1997: Morita H; Takeya K; Itokawa H
Cyclic octapeptides from Stellaria dichotoma var. lanceolata.
Phytochemistry 1997;45(4):841-5.
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1997: Morita H; Gonda A; Wei L; Yamamura Y; Takeya K; Itokawa H
Taxuspinananes A and B, new taxoids from Taxus cuspidata var. nana.
Journal of natural products 1997;60(4):390-2.
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1997: Yun Y S; Morita H; Takeya K; Itokawa H
Cyclic peptides from higher plants. 34. Segetalins G and H, structures and estrogen-like activity of cyclic pentapeptides from Vaccaria segetalis.
Journal of natural products 1997;60(3):216-8.
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1997: Morita H; Yun Y S; Takeya K; Itokawa H; Shirota O
Thionation of segetalins A and B, cyclic peptides with estrogen-like activity from seeds of Vaccaria segetalis.
Bioorganic & medicinal chemistry 1997;5(3):631-6.
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1997: Nagaya H; Tobita Y; Nagae T; Itokawa H; Takeya K; Halim A F; Abdel-Halim O B
Cytotoxic triterpenes from Cleome africana.
Phytochemistry 1997;44(6):1115-9.
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1997: Takano I; Yasuda I; Nishijima M; Yanagi Y; Takeya K; Itokawa H
Ester-type cephalotaxus alkaloids from Cephalotaxus harringtonia var. drupacea.
Phytochemistry 1997;44(4):735-8.
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1996: Morita H; Kayashita T; Takeya K; Itokawa H
Conformational analysis of a cyclic heptapeptide, pseudostellarin D by molecular dynamics and Monte Carlo simulations.
Chemical & pharmaceutical bulletin 1996;44(11):2177-80.
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1996: Takeya K; Quio Z S; Hirobe C; Itokawa H
Cytotoxic trichilin-type limonoids from Melia azedarach.
Bioorganic & medicinal chemistry 1996;4(8):1355-9.
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1996: el-Gamal A A; Takeya K; Itokawa H; Halim A F; Amer M M; Saad H E; Awad S A
Anthraquinones from the polar fractions of Galium sinaicum.
Phytochemistry 1996;42(4):1149-55.
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1996: Takeya K; Qiao Z S; Hirobe C; Itokawa H
Cytotoxic azadirachtin-type limonoids from Melia azedarach.
Phytochemistry 1996;42(3):709-12.
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1996: Morita H; Nagashima S; Uchiumi Y; Kuroki O; Takeya K; Itokawa H
Cyclic peptides from higher plants. XXVIII. Antitumor activity and hepatic microsomal biotransformation of cyclic pentapeptides, astins, from Aster tataricus.
Chemical & pharmaceutical bulletin 1996;44(5):1026-32.
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1996: Morita H; Yun Y S; Takeya K; Itokawa H; Shirota O
A cyclic heptapeptide from Vaccaria segetalis.
Phytochemistry 1996;42(2):439-41.
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1996: Morita H; Kayashita T; Shimomura M; Takeya K; Itokawa H
Cyclic peptides from higher plants. 24.1 yunnanin C, a novel cyclic heptapeptide from Stellaria yunnanensis.
Journal of natural products 1996;59(3):280-2.
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1995: Itokawa H; Yun Y; Morita H; Takeya K; Yamada K
Estrogen-like activity of cyclic peptides from Vaccaria segetalis extracts.
Planta medica 1995;61(6):561-2.
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1995: Morita H; Nagashima S; Takeya K; Itokawa H
Solution forms of antitumor cyclic pentapeptides with 3,4-dichlorinated proline residues, astins A and C, from Aster tataricus.
Chemical & pharmaceutical bulletin 1995;43(8):1395-7.
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1995: Itokawa H; Qiao Z S; Hirobe C; Takeya K
Cytotoxic limonoids and tetranortriterpenoids from Melia azedarach.
Chemical & pharmaceutical bulletin 1995;43(7):1171-5.
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1995: Morita H; Kayashita T; Takeya K; Itokawa H
Cyclic peptides from higher plants, Part 15. Pseudostellarin H, a new cyclic octapeptide from Pseudostellaria heterophylla.
Journal of natural products 1995;58(6):943-7.
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1995: Morita H; Nagashima S; Takeya K; Itokawa H
Structure of a new peptide, astin J, from Aster tataricus.
Chemical & pharmaceutical bulletin 1995;43(2):271-3.
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1994: Shirota O; Morita H; Takeya K; Itokawa H
Cytotoxic aromatic triterpenes from Maytenus ilicifolia and Maytenus chuchuhuasca.
Journal of natural products 1994;57(12):1675-81.
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1994: Itokawa H; Miyashita T; Morita H; Takeya K; Hirano T; Homma M; Oka K
Structural and conformational studies of [Ile7] and [Leu7]surfactins from Bacillus subtilis natto.
Chemical & pharmaceutical bulletin 1994;42(3):604-7.
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1993: Itokawa H; Ibraheim Z Z; Qiao Y F; Takeya K
Anthraquinones, naphthohydroquinones and naphthohydroquinone dimers from Rubia cordifolia and their cytotoxic activity.
Chemical & pharmaceutical bulletin 1993;41(10):1869-72.
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1993: Morita H; Matsumoto K; Takeya K; Itokawa H
Conformation of tropolone ring in antileukemic tropoloisoquinoline alkaloids.
Chemical & pharmaceutical bulletin 1993;41(8):1478-80.
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1993: Morita H; Matsumoto K; Takeya K; Itokawa H; Iitaka Y
Structures and solid state tautomeric forms of two novel antileukemic tropoloisoquinoline alkaloids, pareirubrines A and B, from Cissampelos pareira.
Chemical & pharmaceutical bulletin 1993;41(8):1418-22.
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1993: Itokawa H; Kondo K; Hitotsuyanagi Y; Isomura M; Takeya K
Studies on RA derivatives. V. Synthesis and antitumor activity of Ala2-modified RA-VII derivatives.
Chemical & pharmaceutical bulletin 1993;41(8):1402-10.
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1993: Itokawa H; Kondo K; Hitotsuyanagi Y; Nakamura A; Morita H; Takeya K
Preparation and cytotoxicity of cyclic hexapeptides, RA derivatives.
Chemical & pharmaceutical bulletin 1993;41(7):1266-9.
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1993: Itokawa H; Masuyama K; Morita H; Takeya K
Cytotoxic sesquiterpenes from Nardostachys chinensis.
Chemical & pharmaceutical bulletin 1993;41(6):1183-4.
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1993: Takeya K; Yamamiya T; Morita H; Itokawa H
Two antitumour bicyclic hexapeptides from Rubia cordifolia.
Phytochemistry 1993;33(3):613-5.
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1993: Morita H; Nagashima S; Takeya K; Itokawa H
Astins A and B, antitumor cyclic pentapeptides from Aster tataricus.
Chemical & pharmaceutical bulletin 1993;41(5):992-3.
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1993: Oka K; Hirano T; Homma M; Ishii H; Murakami K; Mogami S; Motizuki A; Morita H; Takeya K; Itokawa H
Satisfactory separation and MS-MS spectrometry of six surfactins isolated from Bacillus subtilis natto.
Chemical & pharmaceutical bulletin 1993;41(5):1000-2.
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1993: Morita H; Yamamiya T; Takeya K; Itokawa H; Sakuma C; Yamada J; Suga T
Conformational recognition of RA-XII by 80S ribosomes: a differential line broadening study in 1H NMR spectroscopy.
Chemical & pharmaceutical bulletin 1993;41(4):781-3.
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1992: Ichihara Y; Takeya K; Hitotsuyanagi Y; Morita H; Okuyama S; Suganuma M; Fujiki H; Motidome M; Itokawa H
Cajucarinolide and isocajucarinolide: anti-inflammatory diterpenes from Croton cajucara.
Planta medica 1992;58(6):549-51.
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1992: Itokawa H; Saitou K; Morita H; Takeya K; Yamada K
Structures and conformations of metabolites of antitumor cyclic hexapeptides, RA-VII and RA-X.
Chemical & pharmaceutical bulletin 1992;40(11):2984-9.
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1992: Morita H; Yamamiya T; Takeya K; Itokawa H
New antitumor bicyclic hexapeptides, RA-XI, -XII, -XIII and -XIV from Rubia cordifolia.
Chemical & pharmaceutical bulletin 1992;40(5):1352-4.
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1992: Itokawa H; Morita H; Takeya K
Solution forms of an antitumor cyclic hexapeptide, RA-VII in dimethyl sulfoxide-d6 from nuclear magnetic resonance studies.
Chemical & pharmaceutical bulletin 1992;40(4):1050-2.
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1991: Itokawa H; Saitou K; Morita H; Takeya K
Conformational analysis of [n-demethyl-Tyr(OCH3)-3]RA-VII, conformationally restricted model approach.
Chemical & pharmaceutical bulletin 1991;39(8):2161-3.
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1991: Itokawa H; Ichihara Y; Mochizuki M; Enomori T; Morita H; Shirota O; Inamatsu M; Takeya K
A cytotoxic substance from Sangre de Grado.
Chemical & pharmaceutical bulletin 1991;39(4):1041-2.
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1991: Morita H; Nakayama M; Kojima H; Takeya K; Itokawa H; Schenkel E P; Motidome M
Structures and cytotoxic activity relationship of casearins, new clerodane diterpenes from Casearia sylvestris Sw.
Chemical & pharmaceutical bulletin 1991;39(3):693-7.
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1990: Itokawa H; Totsuka N; Morita H; Takeya K; Iitaka Y; Schenkel E P; Motidome M
New antitumor principles, casearins A-F, for Casearia sylvestris Sw. (Flacourtiaceae).
Chemical & pharmaceutical bulletin 1990;38(12):3384-8.
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1989: Itokawa H; Totsuka N; Nakahara K; Maezuru M; Takeya K; Kondo M; Inamatsu M; Morita H
A quantitative structure-activity relationship for antitumor activity of long-chain phenols from Ginkgo biloba L.
Chemical & pharmaceutical bulletin 1989;37(6):1619-21.
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1988: Itokawa H; Morita H; Katou I; Takeya K; Cavalheiro A J; de Oliveira R C; Ishige M; Motidome M
Cytotoxic diterpenes from the rhizomes of Hedychium coronarium.
Planta medica 1988;54(4):311-5.
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1988: Itokawa H; Morita H; Takeya K; Motidome M
Diterpenes from rhizomes of Hedychium coronarium.
Chemical & pharmaceutical bulletin 1988;36(7):2682-4.
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1988: Itokawa H; Totsuka N; Takeya K; Watanabe K; Obata E
Antitumor principles from Casearia sylvestris Sw. (Flacourtiaceae), structure elucidation of new clerodane diterpenes by 2-D NMR spectroscopy.
Chemical & pharmaceutical bulletin 1988;36(4):1585-8.
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1987: Itokawa H; Totsuka N; Nakahara K; Takeya K; Lepoittevin J P; Asakawa Y
Antitumor principles from Ginkgo biloba L.
Chemical & pharmaceutical bulletin 1987;35(7):3016-20.
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1987: Itokawa H; Morita H; Sumitomo T; Totsuka N; Takeya K
Antitumour principles from Alpinia galanga.
Planta medica 1987;53(1):32-3.
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