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Laura Itzhaki

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Publications

TOP 3
Maksym Tsytlonok; Laura S Itzhaki
The how's and why's of protein folding intermediates.
Giovanni Settanni; Piotr E Marszalek; Emanuele Paci; David Serquera; Laura S Itzhaki
Effects of ligand binding on the mechanical properties of ankyrin repeat protein gankyrin.
Maksym Tsytlonok; Laura S Itzhaki
Using FlAsH to probe conformational changes in a large HEAT repeat protein.

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All Publications

2013: Maksym Tsytlonok; Laura S Itzhaki
The how's and why's of protein folding intermediates.
Archives of biochemistry and biophysics 2013;531(1-2):14-23.
2013: Giovanni Settanni; Piotr E Marszalek; Emanuele Paci; David Serquera; Laura S Itzhaki
Effects of ligand binding on the mechanical properties of ankyrin repeat protein gankyrin.
PLoS computational biology 2013;9(1):e1002864.
2012: Maksym Tsytlonok; Laura S Itzhaki
Using FlAsH to probe conformational changes in a large HEAT repeat protein.
Chembiochem : a European journal of chemical biology 2012;13(8):1199-205.
2012: Laura S Itzhaki; George D Rose
Folding and binding: lingering questions, emerging answers.
Current opinion in structural biology 2012;22(1):1-3.
2012: Laura S Itzhaki; Alan R Lowe
From artificial antibodies to nanosprings: the biophysical properties of repeat proteins.
Advances in experimental medicine and biology 2012;747():153-66.
2010: Pamela J E Rowling; Rebecca Cook; Laura S Itzhaki
Toward classification of BRCA1 missense variants using a biophysical approach.
The Journal of biological chemistry 2010;285(26):20080-7.
2010: Ben L Murton; Wee Loong Chin; Chris P Ponting; Laura S Itzhaki
Characterising the binding specificities of the subunits associated with the KMT2/Set1 histone lysine methyltransferase.
Journal of molecular biology 2010;398(4):481-8.
2010: David Serquera; Whasil Lee; Giovanni Settanni; Piotr E Marszalek; Emanuele Paci; Laura S Itzhaki
Mechanical unfolding of an ankyrin repeat protein.
Biophysical journal 2010;98(7):1294-301.
2008: Nicolas D Werbeck; Pamela J E Rowling; Vasuki R Chellamuthu; Laura S Itzhaki
Shifting transition states in the unfolding of a large ankyrin repeat protein.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(29):9982-7.
2007: Matthew J Moreau; Adam T McGeoch; Alan R Lowe; Laura S Itzhaki; Steve Bell
ATPase site architecture and helicase mechanism of an archaeal MCM.
Molecular cell 2007;28(2):304-14.
2007: Alan R Lowe; Laura S Itzhaki
Rational redesign of the folding pathway of a modular protein.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(8):2679-84.
2007: Alan R Lowe; Laura S Itzhaki
Biophysical characterisation of the small ankyrin repeat protein myotrophin.
Journal of molecular biology 2007;365(4):1245-55.
2006: Zhong-ping Yao; Min Zhou; Sadie E Kelly; Markus A Seeliger; Carol V Robinson; Laura S Itzhaki
Activation of ubiquitin ligase SCF(Skp2) by Cks1: insights from hydrogen exchange mass spectrometry.
Journal of molecular biology 2006;363(3):673-86.
2006: Frederic Rousseau; Hannah R Wilkinson; Josep Villanueva; Luis Serrano; Joost Schymkowitz; Laura S Itzhaki
Domain swapping in p13suc1 results in formation of native-like, cytotoxic aggregates.
Journal of molecular biology 2006;363(2):496-505.
2006: Reto Bader; Markus A Seeliger; Sadie E Kelly; Leopold L Ilag; Filip Meersman; Alejandra Limones; Ben F Luisi; Christopher M Dobson; Laura S Itzhaki
Folding and fibril formation of the cell cycle protein Cks1.
The Journal of biological chemistry 2006;281(27):18816-24.
2005: Markus A Seeliger; Martin Spichty; Sadie E Kelly; Mark Bycroft; Stefan M V Freund; Martin Karplus; Laura S Itzhaki
Role of conformational heterogeneity in domain swapping and adapter function of the Cks proteins.
The Journal of biological chemistry 2005;280(34):30448-59.
2005: Gayatri B Chavali; Caroline M S Ekblad; Balaku P Basu; Nigel C Brissett; Dmitry B Veprintsev; Luke Hughes-Davies; Tony Kouzarides; Laura S Itzhaki; Aidan J Doherty
Crystal structure of the ENT domain of human EMSY.
Journal of molecular biology 2005;350(5):964-73.
2005: Caroline M S Ekblad; Gayatri B Chavali; Balaku P Basu; Stefan M V Freund; Dmitry B Veprintsev; Luke Hughes-Davies; Tony Kouzarides; Aidan J Doherty; Laura S Itzhaki
Binding of EMSY to HP1beta: implications for recruitment of HP1beta and BS69.
EMBO reports 2005;6(7):675-80.
2004: Caroline M S Ekblad; Assaf Friedler; Dmitry B Veprintsev; Richard L Weinberg; Laura S Itzhaki
Comparison of BRCT domains of BRCA1 and 53BP1: a biophysical analysis.
Protein science : a publication of the Protein Society 2004;13(3):617-25.
2004: Frederic Rousseau; Joost Schymkowitz; Hannah R Wilkinson; Laura S Itzhaki
Intermediates control domain swapping during folding of p13suc1.
The Journal of biological chemistry 2004;279(9):8368-77.
2003: Markus A Seeliger; Sadie E Breward; Assaf Friedler; Oliver Schon; Laura S Itzhaki
Cooperative organization in a macromolecular complex.
Nature structural biology 2003;10(9):718-24.
2003: Frederic Rousseau; Joost Schymkowitz; Laura S Itzhaki
The unfolding story of three-dimensional domain swapping.
Structure (London, England : 1993) 2003;11(3):243-51.
2003: Markus A Seeliger; Sadie E Breward; Laura S Itzhaki
Weak cooperativity in the core causes a switch in folding mechanism between two proteins of the cks family.
Journal of molecular biology 2003;325(1):189-99.
2003: Kit S Tang; Alan Fersht; Laura S Itzhaki
Sequential unfolding of ankyrin repeats in tumor suppressor p16.
Structure (London, England : 1993) 2003;11(1):67-73.
2002: Danielle Sitry; Markus A Seeliger; Tun K Ko; Dvora Ganoth; Sadie E Breward; Laura S Itzhaki; Michele Pagano; Avram Hershko
Three different binding sites of Cks1 are required for p27-ubiquitin ligation.
The Journal of biological chemistry 2002;277(44):42233-40.
2002: Caroline M S Ekblad; Hannah R Wilkinson; Joost Schymkowitz; Frederic Rousseau; Stefan M V Freund; Laura S Itzhaki
Characterisation of the BRCT domains of the breast cancer susceptibility gene product BRCA1.
Journal of molecular biology 2002;320(3):431-42.
2002: Frederic Rousseau; Joost Schymkowitz; Hannah R Wilkinson; Laura S Itzhaki
The structure of the transition state for folding of domain-swapped dimeric p13suc1.
Structure (London, England : 1993) 2002;10(5):649-57.
2002: Markus A Seeliger; Joost Schymkowitz; Frederic Rousseau; Hannah R Wilkinson; Laura S Itzhaki
Folding and association of the human cell cycle regulatory proteins ckshs1 and ckshs2.
Biochemistry 2002;41(4):1202-10.
2001: Joost Schymkowitz; Frederic Rousseau; Hannah R Wilkinson; Assaf Friedler; Laura S Itzhaki
Observation of signal transduction in three-dimensional domain swapping.
Nature structural biology 2001;8(10):888-92.
2001: Frederic Rousseau; Joost Schymkowitz; Hannah R Wilkinson; Laura S Itzhaki
Three-dimensional domain swapping in p13suc1 occurs in the unfolded state and is controlled by conserved proline residues.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(10):5596-601.
2000: Joost Schymkowitz; Frederic Rousseau; Laura S Itzhaki
Sequence conservation provides the best prediction of the role of proline residues in p13suc1.
Journal of molecular biology 2000;301(1):199-204.
2000: Joost Schymkowitz; Frederic Rousseau; L R Irvine; Laura S Itzhaki
The folding pathway of the cell-cycle regulatory protein p13suc1: clues for the mechanism of domain swapping.
Structure (London, England : 1993) 2000;8(1):89-100.
1999: K S Tang; B J Guralnick; W K Wang; Alan Fersht; Laura S Itzhaki
Stability and folding of the tumour suppressor protein p16.
Journal of molecular biology 1999;285(4):1869-86.
1998: Frederic Rousseau; Joost Schymkowitz; M Sánchez del Pino; Laura S Itzhaki
Stability and folding of the cell cycle regulatory protein, p13(suc1).
Journal of molecular biology 1998;284(2):503-19.