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Patrick Iversen

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Frederick J Schnell; Dan V Mourich; Stacy L Crumley; Patrick L Iversen
Development of novel bioanalytical methods to determine the effective concentrations of phosphorodiamidate morpholino oligomers in tissues and cells.
Frederick J Schnell; Sarah Sundholm; Stacy Crumley; Patrick L Iversen; Dan V Mourich
Lymphocytic choriomeningitis virus infection in FVB mouse produces hemorrhagic disease.
Susan E Puckett; Kaleb A Reese; Lucas D Tilley; Michael Freitag; Patrick L Iversen; Rudd C Johnson; Brett L Mellbye; Georgi M Mitev; Valerie Mullen; Kyle R Pomraning; Bruce L Geller
Bacterial resistance to antisense peptide phosphorodiamidate morpholino oligomers.

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All Publications

2013: Frederick J Schnell; Dan V Mourich; Stacy L Crumley; Patrick L Iversen
Development of novel bioanalytical methods to determine the effective concentrations of phosphorodiamidate morpholino oligomers in tissues and cells.
BioResearch open access 2013;2(1):61-6.
2012: Frederick J Schnell; Sarah Sundholm; Stacy Crumley; Patrick L Iversen; Dan V Mourich
Lymphocytic choriomeningitis virus infection in FVB mouse produces hemorrhagic disease.
PLoS pathogens 2012;8(12):e1003073.
2012: Susan E Puckett; Kaleb A Reese; Lucas D Tilley; Michael Freitag; Patrick L Iversen; Rudd C Johnson; Brett L Mellbye; Georgi M Mitev; Valerie Mullen; Kyle R Pomraning; Bruce L Geller
Bacterial resistance to antisense peptide phosphorodiamidate morpholino oligomers.
Antimicrobial agents and chemotherapy 2012;56(12):6147-53.
2012: Patrick L Iversen; Dan V Mourich; Rekha G Panchal; Travis K Warren; Lisa S Welch; Jay B Wells; Nicole L Garza; Sina Bavari
Discovery and early development of AVI-7537 and AVI-7288 for the treatment of Ebola virus and Marburg virus infections.
Viruses 2012;4(11):2806-30.
2010: Travis K Warren; Kelly L Warfield; Jay Wells; Dana L Swenson; Kelly S Donner; Sean A Van Tongeren; Nicole L Garza; Lian Dong; Dan V Mourich; Stacy Crumley; Donald K Nichols; Patrick L Iversen; Sina Bavari
Advanced antisense therapies for postexposure protection against lethal filovirus infections.
Nature medicine 2010;16(9):991-4.
2010: Brett L Mellbye; Dwight D Weller; Jed N Hassinger; Matthew D Reeves; Candace E Lovejoy; Patrick L Iversen; Bruce L Geller
Cationic phosphorodiamidate morpholino oligomers efficiently prevent growth of Escherichia coli in vitro and in vivo.
The Journal of antimicrobial chemotherapy 2010;65(1):98-106.
2009: Georgi M Mitev; Brett L Mellbye; Patrick L Iversen; Bruce L Geller
Inhibition of intracellular growth of Salmonella enterica serovar Typhimurium in tissue culture by antisense peptide-phosphorodiamidate morpholino oligomer.
Antimicrobial agents and chemotherapy 2009;53(9):3700-4.
2009: Dan V Mourich; Jessica L Jendrzejewski; Nikki B Marshall; David J Hinrichs; Patrick L Iversen; Rhonda M Brand
Antisense targeting of cFLIP sensitizes activated T cells to undergo apoptosis and desensitizes responses to contact dermatitis.
The Journal of investigative dermatology 2009;129(8):1945-53.
2009: Rekha G Panchal; Ricky L Ulrich; Steven B Bradfute; Douglas Lane; Gordon Ruthel; Tara A Kenny; Patrick L Iversen; Arthur O. Anderson; Rick Gussio; William C Raschke; Sina Bavari
Reduced expression of CD45 protein-tyrosine phosphatase provides protection against anthrax pathogenesis.
The Journal of biological chemistry 2009;284(19):12874-85.
2009: Dana L Swenson; Kelly L Warfield; Travis K Warren; Candace Lovejoy; Jed N Hassinger; Gordon Ruthel; Robert E Blouch; Hong M Moulton; Dwight D Weller; Patrick L Iversen; Sina Bavari
Chemical modifications of antisense morpholino oligomers enhance their efficacy against Ebola virus infection.
Antimicrobial agents and chemotherapy 2009;53(5):2089-99.
2009: Dan V Mourich; Patrick L Iversen
Splicing in the immune system: potential targets for therapeutic intervention by antisense-mediated alternative splicing.
Current opinion in molecular therapeutics 2009;11(2):124-32.
2009: Brett L Mellbye; Susan E Puckett; Lucas D Tilley; Patrick L Iversen; Bruce L Geller
Variations in amino acid composition of antisense peptide-phosphorodiamidate morpholino oligomer affect potency against Escherichia coli in vitro and in vivo.
Antimicrobial agents and chemotherapy 2009;53(2):525-30.
2009: Chalermchai Mitrpant; Sue Fletcher; Patrick L Iversen; Stephen D Wilton
By-passing the nonsense mutation in the 4 CV mouse model of muscular dystrophy by induced exon skipping.
The journal of gene medicine 2009;11(1):46-56.
2008: Rachida Abes; Hong M Moulton; Philippe Clair; Sung-Tae Yang; Saïd Abes; Kamran Melikov; Paul Prevot; Derek S Youngblood; Patrick L Iversen; Leonid V Chernomordik; Bernard Lebleu
Delivery of steric block morpholino oligomers by (R-X-R)4 peptides: structure-activity studies.
Nucleic acids research 2008;36(20):6343-54.
2008: David A Stein; Claire Y-H Huang; Shawn Silengo; Adams Amantana; Stacy Crumley; Robert E Blouch; Patrick L Iversen; Richard M Kinney
Treatment of AG129 mice with antisense morpholino oligomers increases survival time following challenge with dengue 2 virus.
The Journal of antimicrobial chemotherapy 2008;62(3):555-65.
2008: Harmanjatinder S Sekhon; Carla A London; Mypinder Sekhon; Patrick L Iversen; Gayathri Devi
c-MYC antisense phosphosphorodiamidate morpholino oligomer inhibits lung metastasis in a murine tumor model.
Lung cancer (Amsterdam, Netherlands) 2008;60(3):347-54.
2008: Gülsah Gabriel; Alexandra Nordmann; David A Stein; Patrick L Iversen; Hans-Dieter Klenk
Morpholino oligomers targeting the PB1 and NP genes enhance the survival of mice infected with highly pathogenic influenza A H7N7 virus.
The Journal of general virology 2008;89(Pt 4):939-48.
2008: Bo Zhang; Hongping Dong; David A Stein; Patrick L Iversen; Pei-Yong Shi
West Nile virus genome cyclization and RNA replication require two pairs of long-distance RNA interactions.
Virology 2008;373(1):1-13.
2008: Bernard Lebleu; Hong M Moulton; Rachida Abes; Gabriela Ivanova; Saïd Abes; David A Stein; Patrick L Iversen; Andrey A Arzumanov; Michael J Gait
Cell penetrating peptide conjugates of steric block oligonucleotides.
Advanced drug delivery reviews 2008;60(4-5):517-29.
2008: Christopher Lupfer; David A Stein; Dan V Mourich; Samuel E Tepper; Patrick L Iversen; Manoj Pastey
Inhibition of influenza A H3N8 virus infections in mice by morpholino oligomers.
Archives of virology 2008;153(5):929-37.
2008: Alvin W Smith; Patrick L Iversen; Peter D O'Hanley; Douglas E Skilling; Janet R Christensen; Sherry S Weaver; Kimberli Longley; Michael A Stone; Steve E Poet; David O Matson
Virus-specific antiviral treatment for controlling severe and fatal outbreaks of feline calicivirus infection.
American journal of veterinary research 2008;69(1):23-32.
2007: Lynn S Silvestri; Gordon Ruthel; George Kallstrom; Kelly L Warfield; Dana L Swenson; Timothy Nelle; Patrick L Iversen; Sina Bavari; M Javad Aman
Involvement of vacuolar protein sorting pathway in Ebola virus release independent of TSG101 interaction.
The Journal of infectious diseases 2007;196 Suppl 2():S264-70.
2007: Susan Fletcher; Kaite Honeyman; Abbie M Fall; Penny L Harding; Russell D Johnsen; Joshua P Steinhaus; Hong M Moulton; Patrick L Iversen; Stephen D Wilton
Morpholino oligomer-mediated exon skipping averts the onset of dystrophic pathology in the mdx mouse.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(9):1587-92.
2007: Nikki B Marshall; S K Oda; C A London; Hong M Moulton; Patrick L Iversen; Nancy Kerkvliet; Dan V Mourich
Arginine-rich cell-penetrating peptides facilitate delivery of antisense oligomers into murine leukocytes and alter pre-mRNA splicing.
Journal of immunological methods 2007;325(1-2):114-26.
2007: Hong M Moulton; Susan Fletcher; Benjamin W Neuman; Graham McClorey; David A Stein; Saïd Abes; Stephen D Wilton; M J Buchmeier; Bernard Lebleu; Patrick L Iversen
Cell-penetrating peptide-morpholino conjugates alter pre-mRNA splicing of DMD (Duchenne muscular dystrophy) and inhibit murine coronavirus replication in vivo.
Biochemical Society transactions 2007;35(Pt 4):826-8.
2007: R Abes; Andrey A Arzumanov; Hong M Moulton; Saïd Abes; Gabriela Ivanova; Patrick L Iversen; Michael J Gait; Bernard Lebleu
Cell-penetrating-peptide-based delivery of oligonucleotides: an overview.
Biochemical Society transactions 2007;35(Pt 4):775-9.
2007: Adams Amantana; Hong M Moulton; Melissa L Cate; Muralimohan T Reddy; Tom Whitehead; Jed N Hassinger; Derek S Youngblood; Patrick L Iversen
Pharmacokinetics, biodistribution, stability and toxicity of a cell-penetrating peptide-morpholino oligomer conjugate.
Bioconjugate chemistry 2007;18(4):1325-31.
2007: Tia S Deas; Corey J Bennett; Susan A Jones; Mark Tilgner; Ping Ren; Melissa J Behr; David A Stein; Patrick L Iversen; Laura D Kramer; Kristen A Bernard; Pei-Yong Shi
In vitro resistance selection and in vivo efficacy of morpholino oligomers against West Nile virus.
Antimicrobial agents and chemotherapy 2007;51(7):2470-82.
2007: Renaud BURRER; Benjamin W Neuman; Joey P C Ting; David A Stein; Hong M Moulton; Patrick L Iversen; Peter Kuhn; Michael J Buchmeier
Antiviral effects of antisense morpholino oligomers in murine coronavirus infection models.
Journal of virology 2007;81(11):5637-48.
2007: Rebecca P Wu; Derek S Youngblood; Jed N Hassinger; Candace E Lovejoy; Michelle H Nelson; Patrick L Iversen; Hong M Moulton
Cell-penetrating peptides as transporters for morpholino oligomers: effects of amino acid composition on intracellular delivery and cytotoxicity.
Nucleic acids research 2007;35(15):5182-91.
2007: Abbie M Adams; Penny L Harding; Patrick L Iversen; Catherine Coleman; Susan Fletcher; Stephen D Wilton
Antisense oligonucleotide induced exon skipping and the dystrophin gene transcript: cocktails and chemistries.
BMC molecular biology 2007;8():57.
2007: Derek S Youngblood; Susie A Hatlevig; Jed N Hassinger; Patrick L Iversen; Hong M Moulton
Stability of cell-penetrating peptide-morpholino oligomer conjugates in human serum and in cells.
Bioconjugate chemistry 2007;18(1):50-60.
2007: Lucas D Tilley; Brett L Mellbye; Susan E Puckett; Patrick L Iversen; Bruce L Geller
Antisense peptide-phosphorodiamidate morpholino oligomer conjugate: dose-response in mice infected with Escherichia coli.
The Journal of antimicrobial chemotherapy 2007;59(1):66-73.
2007: Yanjin Zhang; Kai-Yu Wang; David A Stein; Deendayal Patel; Rheba Watkins; Hong M Moulton; Patrick L Iversen; David O Matson
Inhibition of replication and transcription activator and latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus by morpholino oligomers.
Antiviral research 2007;73(1):12-23.
2006: Saïd Abes; Hong M Moulton; Philippe Clair; Paul Prevot; Derek S Youngblood; Rebecca P Wu; Patrick L Iversen; Bernard Lebleu
Vectorization of morpholino oligomers by the (R-Ahx-R)4 peptide allows efficient splicing correction in the absence of endosomolytic agents.
Journal of controlled release : official journal of the Controlled Release Society 2006;116(3):304-13.
2006: Ji Yuan; David A Stein; Travis Lim; Dexin Qiu; Shaun Coughlin; Zhen Liu; Yinjing Wang; Robert Blouch; Hong M Moulton; Patrick L Iversen; Decheng Yang
Inhibition of coxsackievirus B3 in cell cultures and in mice by peptide-conjugated morpholino oligomers targeting the internal ribosome entry site.
Journal of virology 2006;80(23):11510-9.
2006: Qing Ge; Manoj Pastey; Darwyn Kobasa; Piliapan Puthavathana; Christopher Lupfer; Richard K Bestwick; Patrick L Iversen; Jianzhu Chen; David A Stein
Inhibition of multiple subtypes of influenza A virus in cell cultures with morpholino oligomers.
Antimicrobial agents and chemotherapy 2006;50(11):3724-33.
2006: Yanjin Zhang; David A Stein; Su-Min Fan; Kai-Yu Wang; Andrew D Kroeker; Xiang-Jin Meng; Patrick L Iversen; David O Matson
Suppression of porcine reproductive and respiratory syndrome virus replication by morpholino antisense oligomers.
Veterinary microbiology 2006;117(2-4):117-29.
2006: Graham McClorey; Abbie M Fall; Hong M Moulton; Patrick L Iversen; John Rasko; M Ryan; Susan Fletcher; Stephen D Wilton
Induced dystrophin exon skipping in human muscle explants.
Neuromuscular disorders : NMD 2006;16(9-10):583-90.
2006: Graham McClorey; Hong M Moulton; Patrick L Iversen; Susan Fletcher; Stephen D Wilton
Antisense oligonucleotide-induced exon skipping restores dystrophin expression in vitro in a canine model of DMD.
Gene therapy 2006;13(19):1373-81.
2006: Lucas D Tilley; Orion S Hine; Jill A Kellogg; Jed N Hassinger; Dwight D Weller; Patrick L Iversen; Bruce L Geller
Gene-specific effects of antisense phosphorodiamidate morpholino oligomer-peptide conjugates on Escherichia coli and Salmonella enterica serovar typhimurium in pure culture and in tissue culture.
Antimicrobial agents and chemotherapy 2006;50(8):2789-96.
2006: Alvin W Smith; Patrick L Iversen; Douglas E Skilling; David A Stein; Karin Bok; David O Matson
Vesivirus viremia and seroprevalence in humans.
Journal of medical virology 2006;78(5):693-701.
2006: Sven Enterlein; Kelly L Warfield; Dana L Swenson; David A Stein; Jeffery L Smith; C Scott Gamble; Andrew D Kroeker; Patrick L Iversen; Sina Bavari; Elke Mühlberger
VP35 knockdown inhibits Ebola virus amplification and protects against lethal infection in mice.
Antimicrobial agents and chemotherapy 2006;50(3):984-93.
2006: Brinda Mahadevan; Vikram Arora; Laura J Schild; Channa Keshava; Melissa L Cate; Patrick L Iversen; Miriam C Poirier; Ainsley Weston; Cliff Pereira; William M Baird
Reduction in tamoxifen-induced CYP3A2 expression and DNA adducts using antisense technology.
Molecular carcinogenesis 2006;45(2):118-25.
2006: Benjamin W Neuman; David A Stein; Andrew D Kroeker; Hong M Moulton; Richard K Bestwick; Patrick L Iversen; Michael J Buchmeier
Inhibition and escape of SARS-CoV treated with antisense morpholino oligomers.
Advances in experimental medicine and biology 2006;581():567-71.
2006: Kelly L Warfield; Dana L Swenson; Gene Garrard Olinger; Donald K Nichols; William D Pratt; Robert Blouch; David A Stein; M Javad Aman; Patrick L Iversen; Sina Bavari
Gene-specific countermeasures against Ebola virus based on antisense phosphorodiamidate morpholino oligomers.
PLoS pathogens 2006;2(1):e1.
2005: Adams Amantana; Patrick L Iversen
Pharmacokinetics and biodistribution of phosphorodiamidate morpholino antisense oligomers.
Current opinion in pharmacology 2005;5(5):550-5.
2005: Benjamin W Neuman; David A Stein; Andrew D Kroeker; Michael J Churchill; Alice M Kim; Peter Kuhn; Philip Dawson; Hong M Moulton; Richard K Bestwick; Patrick L Iversen; Michael J Buchmeier
Inhibition, escape, and attenuated growth of severe acute respiratory syndrome coronavirus treated with antisense morpholino oligomers.
Journal of virology 2005;79(15):9665-76.
2005: José M Martín-Alonso; Douglas E Skilling; Lorenzo González-Molleda; Gloria del Barrio; Angeles Machín; Nathan K Keefer; David O Matson; Patrick L Iversen; Alvin W Smith; Francisco Parra
Isolation and characterization of a new Vesivirus from rabbits.
Virology 2005;337(2):373-83.
2005: Michelle H Nelson; David A Stein; Andrew D Kroeker; Susie A Hatlevig; Patrick L Iversen; Hong M Moulton
Arginine-rich peptide conjugation to morpholino oligomers: effects on antisense activity and specificity.
Bioconjugate chemistry 2005;16(4):959-66.
2005: Bruce L Geller; Jesse Deere; Lucas D Tilley; Patrick L Iversen
Antisense phosphorodiamidate morpholino oligomer inhibits viability of Escherichia coli in pure culture and in mouse peritonitis.
The Journal of antimicrobial chemotherapy 2005;55(6):983-8.
2005: Gayathri Devi; Tomasz M Beer; Christopher L Corless; Vikram Arora; Doreen L Weller; Patrick L Iversen
In vivo bioavailability and pharmacokinetics of a c-MYC antisense phosphorodiamidate morpholino oligomer, AVI-4126, in solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(10):3930-8.
2005: Richard M Kinney; Claire Y-H Huang; Becky C Rose; Andrew D Kroeker; Theo W Dreher; Patrick L Iversen; David A Stein
Inhibition of dengue virus serotypes 1 to 4 in vero cell cultures with morpholino oligomers.
Journal of virology 2005;79(8):5116-28.
2005: Tia S Deas; Iwona Binduga-Gajewska; Mark Tilgner; Ping Ren; David A Stein; Hong M Moulton; Patrick L Iversen; Elizabeth B Kauffman; Laura D Kramer; Pei-Yong Shi
Inhibition of flavivirus infections by antisense oligomers specifically suppressing viral translation and RNA replication.
Journal of virology 2005;79(8):4599-609.
2005: Rhonda M Brand; Patrick L Iversen
Transdermal delivery of antisense oligonucleotides.
Methods in molecular medicine 2005;106():255-69.
2004: Vikram Arora; Gayathri Devi; Patrick L Iversen
Neutrally charged phosphorodiamidate morpholino antisense oligomers: uptake, efficacy and pharmacokinetics.
Current pharmaceutical biotechnology 2004;5(5):431-9.
2004: Yoo-Joung Ko; Gayathri Devi; Carla A London; Anthony Kayas; Muralimohan T Reddy; Patrick L Iversen; Glenn J Bubley; Steven P Balk
Androgen receptor down-regulation in prostate cancer with phosphorodiamidate morpholino antisense oligomers.
The Journal of urology 2004;172(3):1140-4.
2004: Adams Amantana; Carla A London; Patrick L Iversen; Gayathri Devi
X-linked inhibitor of apoptosis protein inhibition induces apoptosis and enhances chemotherapy sensitivity in human prostate cancer cells.
Molecular cancer therapeutics 2004;3(6):699-707.
2004: Benjamin W Neuman; David A Stein; Andrew D Kroeker; Amy D Paulino; Hong M Moulton; Patrick L Iversen; Michael J Buchmeier
Antisense morpholino-oligomers directed against the 5' end of the genome inhibit coronavirus proliferation and growth.
Journal of virology 2004;78(11):5891-9.
2004: Angela K Pannier; Vikram Arora; Patrick L Iversen; Rhonda M Brand
Transdermal delivery of phosphorodiamidate Morpholino oligomers across hairless mouse skin.
International journal of pharmaceutics 2004;275(1-2):217-26.
2004: Hong M Moulton; Michelle H Nelson; Susie A Hatlevig; Muralimohan T Reddy; Patrick L Iversen
Cellular uptake of antisense morpholino oligomers conjugated to arginine-rich peptides.
Bioconjugate chemistry 2004;15(2):290-9.
2003: Carla A London; Harmanjatinder S Sekhon; Vikram Arora; David A Stein; Patrick L Iversen; Gayathri Devi
A novel antisense inhibitor of MMP-9 attenuates angiogenesis, human prostate cancer cell invasion and tumorigenicity.
Cancer gene therapy 2003;10(11):823-32.
2003: Bruce L Geller; Jesse Deere; David A Stein; Andrew D Kroeker; Hong M Moulton; Patrick L Iversen
Inhibition of gene expression in Escherichia coli by antisense phosphorodiamidate morpholino oligomers.
Antimicrobial agents and chemotherapy 2003;47(10):3233-9.
2003: Patrick L Iversen; Vikram Arora; A J Acker; David H Mason; Gayathri Devi
Efficacy of antisense morpholino oligomer targeted to c-myc in prostate cancer xenograft murine model and a Phase I safety study in humans.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(7):2510-9.
2003: Patrick L Iversen; Dan V Mourich; Hong M Moulton
Monoclonal antibodies to two epitopes of beta-human chorionic gonadotropin for the treatment of cancer.
Current opinion in molecular therapeutics 2003;5(2):156-60.
2003: Hong M Moulton; Michelle C Hase; Kristen M Smith; Patrick L Iversen
HIV Tat peptide enhances cellular delivery of antisense morpholino oligomers.
Antisense & nucleic acid drug development 2003;13(1):31-43.
2003: Derek C Knapp; John E Mata; Muralimohan T Reddy; Gayathri Devi; Patrick L Iversen
Resistance to chemotherapeutic drugs overcome by c-Myc inhibition in a Lewis lung carcinoma murine model.
Anti-cancer drugs 2003;14(1):39-47.
2002: Gayathri Devi; Jennifer R Oldenkamp; Carla A London; Patrick L Iversen
Inhibition of human chorionic gonadotropin beta-subunit modulates the mitogenic effect of c-myc in human prostate cancer cells.
The Prostate 2002;53(3):200-10.
2002: Vikram Arora; Tracy L Hannah; Patrick L Iversen; Rhonda M Brand
Transdermal use of phosphorodiamidate morpholino oligomer AVI-4472 inhibits cytochrome P450 3A2 activity in male rats.
Pharmaceutical research 2002;19(10):1465-70.
2002: Hong M Moulton; Paul H Yoshihara; David H Mason; Patrick L Iversen; Pierre L Triozzi
Active specific immunotherapy with a beta-human chorionic gonadotropin peptide vaccine in patients with metastatic colorectal cancer: antibody response is associated with improved survival.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(7):2044-51.
2002: Vikram Arora; Melissa L Cate; Chandramallika Ghosh; Patrick L Iversen
Phosphorodiamidate morpholino antisense oligomers inhibit expression of human cytochrome P450 3A4 and alter selected drug metabolism.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(7):757-62.
2002: Alvin W Smith; David O Matson; David A Stein; Douglas E Skilling; Andrew D Kroeker; Tamas Berke; Patrick L Iversen
Antisense treatment of caliciviridae: an emerging disease agent of animals and humans.
Current opinion in molecular therapeutics 2002;4(2):177-84.
2002: Vikram Arora; Derek C Knapp; Muralimohan T Reddy; Dwight D Weller; Patrick L Iversen
Bioavailability and efficacy of antisense morpholino oligomers targeted to c-myc and cytochrome P-450 3A2 following oral administration in rats.
Journal of pharmaceutical sciences 2002;91(4):1009-18.
2002: Alvin W Smith; Douglas E Skilling; David O Matson; Andrew D Kroeker; David A Stein; Tamas Berke; Patrick L Iversen
Detection of vesicular exanthema of swine-like calicivirus in tissues from a naturally infected spontaneously aborted bovine fetus.
Journal of the American Veterinary Medical Association 2002;220(4):455-8.
2001: David A Stein; Douglas E Skilling; Patrick L Iversen; Alvin W Smith
Inhibition of Vesivirus infections in mammalian tissue culture with antisense morpholino oligomers.
Antisense & nucleic acid drug development 2001;11(5):317-25.
2001: J Graham Sharp; Michael Bishop; B Copple; Timothy C Greiner; Patrick L Iversen; John D Jackson; Shantaram S Joshi; Eric J Benner; SL Mann; A K Rao; Julie M Vose
Oligonucleotide enhanced cytotoxicity of Idarubicin for lymphoma cells.
Leukemia & lymphoma 2001;42(3):417-27.
2001: V Arora; Patrick L Iversen
Redirection of drug metabolism using antisense technology.
Current opinion in molecular therapeutics 2001;3(3):249-57.
2001: Patrick L Iversen
Phosphorodiamidate morpholino oligomers: favorable properties for sequence-specific gene inactivation.
Current opinion in molecular therapeutics 2001;3(3):235-8.
2001: Rhonda M Brand; Tracy L Hannah; J Norris; Patrick L Iversen
Transdermal delivery of antisense oligonucleotides can induce changes in gene expression in vivo.
Antisense & nucleic acid drug development 2001;11(1):1-6.
2000: Rhonda M Brand; Patrick L Iversen
Transdermal delivery of antisense compounds.
Advanced drug delivery reviews 2000;44(1):51-7.
2000: R M Hudziak; J Summerton; Dwight D Weller; Patrick L Iversen
Antiproliferative effects of steric blocking phosphorodiamidate morpholino antisense agents directed against c-myc.
Antisense & nucleic acid drug development 2000;10(3):163-76.
2000: John E Mata; John D Jackson; Shantaram S Joshi; WG Tracewell; Samuel J Pirruccello; Brian J Murphy; Michael Bishop; Patrick L Iversen
Pharmacokinetics and in vivo effects of a six-base phosphorothioate oligodeoxynucleotide with anticancer and hematopoietic activities in swine.
Journal of hematotherapy & stem cell research 2000;9(2):205-14.
2000: Vikram Arora; Derek C Knapp; B L Smith; M L Statdfield; D A Stein; Muralimohan T Reddy; Dwight D Weller; Patrick L Iversen
c-Myc antisense limits rat liver regeneration and indicates role for c-Myc in regulating cytochrome P-450 3A activity.
The Journal of pharmacology and experimental therapeutics 2000;292(3):921-8.
2000: V Arora; Patrick L Iversen
Antisense oligonucleotides targeted to the p53 gene modulate liver regeneration in vivo.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(2):131-8.
2000: John E Mata; Michael Bishop; stefano r tarantolo; C R Angel; Stanley A Swanson; Patrick L Iversen
Evidence of enhanced iron excretion during systemic phosphorothioate oligodeoxynucleotide treatment.
Journal of toxicology. Clinical toxicology 2000;38(4):383-7.
1999: Patrick L Iversen; K G Cornish; L J Iversen; John E Mata; David B Bylund
Bolus intravenous injection of phosphorothioate oligonucleotides causes hypotension by acting as alpha(1)-adrenergic receptor antagonists.
Toxicology and applied pharmacology 1999;160(3):289-96.
1999: Todd Page; John E Mata; J A Bridge; J C Siebler; James R Neff; Patrick L Iversen
The cytotoxic effects of single-stranded telomere mimics on OMA-BL1 cells.
Experimental cell research 1999;252(1):41-9.
1998: Rhonda M Brand; K Haase; Tracy L Hannah; Patrick L Iversen
An experimental model for interpreting percutaneous penetration of oligonucleotides that incorporates the role of keratinocytes.
The Journal of investigative dermatology 1998;111(6):1166-71.
1998: R Joshi; V Arora; J P Desjardins; D Robinson; K J Himmelstein; Patrick L Iversen
In vivo properties of an in situ forming gel for parenteral delivery of macromolecular drugs.
Pharmaceutical research 1998;15(8):1189-95.
1998: V Arora; Patrick L Iversen; Manuchair Ebadi
Manipulation of metallothionein expression in the regenerating rat liver using antisense oligonucleotides.
Biochemical and biophysical research communications 1998;246(3):711-8.
1998: Rhonda M Brand; A Wahl; Patrick L Iversen
Effects of size and sequence on the iontophoretic delivery of oligonucleotides.
Journal of pharmaceutical sciences 1998;87(1):49-52.
1997: Michael Bishop; John D Jackson; stefano r tarantolo; B O'Kane-Murphy; Patrick L Iversen; E Bayever; S M Joshi; J Graham Sharp; J L Pierson; Phyllis I Warkentin; James O Armitage; Anne Kessinger
Ex vivo treatment of bone marrow with phosphorothioate oligonucleotide OL(1)p53 for autologous transplantation in acute myelogenous leukemia and myelodysplastic syndrome.
Journal of hematotherapy 1997;6(5):441-6.
1997: Atsushi Takeda; H Hisada; S Okada; John E Mata; M Ebadi; Patrick L Iversen
Tumor cell growth is inhibited by suppressing metallothionein-I synthesis.
Cancer letters 1997;116(2):145-9.
1997: H K Tewary; Patrick L Iversen
Qualitative and quantitative measurements of oligonucleotides in gene therapy: Part II in vivo models.
Journal of pharmaceutical and biomedical analysis 1997;15(8):1127-35.
1997: John E Mata; Shantaram S Joshi; B Palen; Samuel J Pirruccello; John D Jackson; N Elias; Todd Page; K L Medlin; Patrick L Iversen
A hexameric phosphorothioate oligonucleotide telomerase inhibitor arrests growth of Burkitt's lymphoma cells in vitro and in vivo.
Toxicology and applied pharmacology 1997;144(1):189-97.
1997: H K Tewary; Patrick L Iversen
Qualitative and quantitative measurements of oligonucleotides in gene therapy: Part I. In vitro models.
Journal of pharmaceutical and biomedical analysis 1997;15(7):857-73.
1996: J P Desjardins; BS Sproat; B Beijer; M Blaschke; M Dunkel; W Gerdes; J Ludwig; V Reither; T Rupp; Patrick L Iversen
Pharmacokinetics of a synthetic, chemically modified hammerhead ribozyme against the rat cytochrome P-450 3A2 mRNA after single intravenous injections.
The Journal of pharmacology and experimental therapeutics 1996;278(3):1419-27.
1996: Thomas R Porter; Patrick L Iversen; S Li; F Xie
Interaction of diagnostic ultrasound with synthetic oligonucleotide-labeled perfluorocarbon-exposed sonicated dextrose albumin microbubbles.
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 1996;15(8):577-84.
1996: Rhonda M Brand; Patrick L Iversen
Iontophoretic delivery of a telomeric oligonucleotide.
Pharmaceutical research 1996;13(6):851-4.
1996: Michael Bishop; Patrick L Iversen; E Bayever; J Graham Sharp; Timothy C Greiner; B L Copple; R Ruddon; G Zon; J Spinolo; M Arneson; James O Armitage; Anne Kessinger
Phase I trial of an antisense oligonucleotide OL(1)p53 in hematologic malignancies.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1996;14(4):1320-6.
1995: A G Wu; Shantaram S Joshi; Wing C Chan; Patrick L Iversen; John D Jackson; Anne Kessinger; Samuel J Pirruccello; Warren G Sanger; J Graham Sharp; D J Verbik
Effects of BCR-ABL antisense oligonucleotides (AS-ODN) on human chronic myeloid leukemic cells: AS-ODN as effective purging agents.
Leukemia & lymphoma 1995;20(1-2):67-76.
1995: Patrick L Iversen; B L Copple; H K Tewary
Pharmacology and toxicology of phosphorothioate oligonucleotides in the mouse, rat, monkey and man.
Toxicology letters 1995;82-83():425-30.
1995: J P Desjardins; Patrick L Iversen
Inhibition of the rat cytochrome P450 3A2 by an antisense phosphorothioate oligodeoxynucleotide in vivo.
The Journal of pharmacology and experimental therapeutics 1995;275(3):1608-13.
1995: Manuchair Ebadi; Patrick L Iversen; R Hao; D R Cerutis; P Rojas; H Kevin Happe; Leonard Murrin; Ronald F Pfeiffer
Expression and regulation of brain metallothionein.
Neurochemistry international 1995;27(1):1-22.
1995: B L Copple; W M Gmeiner; Patrick L Iversen
Reaction between metabolically activated acetaminophen and phosphorothioate oligonucleotides.
Toxicology and applied pharmacology 1995;133(1):53-63.
1995: Mu Wang; J Mata; C E Price; Patrick L Iversen; M Godfrey
Prenatal and presymptomatic diagnosis of the Marfan syndrome using fluorescence PCR and an automated sequencer.
Prenatal diagnosis 1995;15(6):499-507.
1995: S K Srinivasan; H K Tewary; Patrick L Iversen
Characterization of binding sites, extent of binding, and drug interactions of oligonucleotides with albumin.
Antisense research and development 1995;5(2):131-9.
1994: Manuchair Ebadi; Patrick L Iversen
Metallothionein in carcinogenesis and cancer chemotherapy.
General pharmacology 1994;25(7):1297-310.
1994: John K DiBaise; Manuchair Ebadi; Patrick L Iversen
Patterns of cellular uptake and effects on cell survival using antimetallothionein oligodeoxyribonucleotide conjugates in vitro.
Biological signals 1994;3(3):140-9.
1994: A Takeda; J S Norris; Patrick L Iversen; Manuchair Ebadi
Antisense oligonucleotide of c-myc discriminates between zinc- and dexamethasone-induced synthesis of metallothionein.
Pharmacology 1994;48(2):119-26.
1994: E Bayever; K M Haines; Patrick L Iversen; R W Ruddon; Samuel J Pirruccello; C P Mountjoy; M A Arneson; L J Smith
Selective cytotoxicity to human leukemic myeloblasts produced by oligodeoxyribonucleotide phosphorothioates complementary to p53 nucleotide sequences.
Leukemia & lymphoma 1994;12(3-4):223-31.
1994: Patrick L Iversen; J Mata; W G Tracewell; G Zon
Pharmacokinetics of an antisense phosphorothioate oligodeoxynucleotide against rev from human immunodeficiency virus type 1 in the adult male rat following single injections and continuous infusion.
Antisense research and development 1994;4(1):43-52.
1994: Samuel J Pirruccello; G A Perry; P Bock; M S Lang; S M Noel; G Zon; Patrick L Iversen
HIV-1 rev antisense phosphorothioate oligonucleotide binding to human mononuclear cells is cell type specific and inducible.
Antisense research and development 1994;4(4):285-9.
1994: Michael Bishop; Phyllis I Warkentin; John D Jackson; E Bayever; Patrick L Iversen; V I Whalen; J Lastovica; K Haines; Anne Kessinger
Antisense oligonucleotide OL (1) p53 for in vitro purging of autologous bone marrow in acute myelogenous leukemia.
Progress in clinical and biological research 1994;389():183-7.
1993: E Bayever; Patrick L Iversen; Michael Bishop; J Graham Sharp; H K Tewary; M A Arneson; Samuel J Pirruccello; R W Ruddon; Anne Kessinger; G Zon
Systemic administration of a phosphorothioate oligonucleotide with a sequence complementary to p53 for acute myelogenous leukemia and myelodysplastic syndrome: initial results of a phase I trial.
Antisense research and development 1993;3(4):383-90.
1992: Patrick L Iversen; John E Mata; Manuchair Ebadi
Synthetic antisense oligonucleotide probes the essentiality of metallothionein gene.
Biological signals 1992;1(6):293-9.
1992: Patrick L Iversen; Manuchair Ebadi
Antisense oligonucleotide-mediated inhibition of metallothionein protein synthesis in neuroblastoma IMR 32 and Chang liver cells in culture.
Biological signals 1992;1(2):57-64.
1992: K D Kumble; Patrick L Iversen; Jamboor K Vishwanatha
The role of primer recognition proteins in DNA replication: inhibition of cellular proliferation by antisense oligodeoxyribonucleotides.
Journal of cell science 1992;101 ( Pt 1)():35-41.
1992: Patrick L Iversen; D Crouse; G Zon; G Perry
Binding of antisense phosphorothioate oligonucleotides to murine lymphocytes is lineage specific and inducible.
Antisense research and development 1992;2(3):223-33.
1992: Patrick L Iversen; S Zhu; A Meyer; G Zon
Cellular uptake and subcellular distribution of phosphorothioate oligonucleotides into cultured cells.
Antisense research and development 1992;2(3):211-22.
1991: P Raval; Patrick L Iversen; E Bresnick
Induction of cytochromes P450IA1 and P450IA2 as determined by solution hybridization.
Biochemical pharmacology 1991;41(11):1719-23.
1990: V K Paliwal; Patrick L Iversen; Manuchair Ebadi
Regulation of zinc metallothionein II mRNA level in rat brain.
Neurochemistry international 1990;17(3):441-7.
1987: Patrick L Iversen; L I Siegel; K Rahner; E Bresnick
Synergy of phenobarbital and 3-methylcholanthrene in "superinduction" of cytochrome P-450c mRNA but not enzyme activity.
Biochemical pharmacology 1987;36(20):3399-403.