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Gwen Ivy

Research Profile

Chemicals & Drugs

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Neurologic Kindling

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TOP 3
Sean Chung; Gwen O Ivy; Stephen G Reid
GABA-mediated neurotransmission in the nucleus of the solitary tract alters resting ventilation following exposure to chronic hypoxia in conscious rats.
Kenichi Kitani; Setsuko Kanai; Kyoko Miyasaka; Maria-Cristina Carrillo; Gwen O Ivy
The necessity of having a proper dose of (-)deprenyl (D) to prolong the life spans of rats explains discrepancies among different studies in the past.
Mani Vessal; Chandrasagar B Dugani; Dianand A Solomon; W McIntyre Burnham; Gwen O Ivy
Might astrocytes play a role in maintaining the seizure-prone state?

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All Publications

2006: Sean Chung; Gwen O Ivy; Stephen G Reid
GABA-mediated neurotransmission in the nucleus of the solitary tract alters resting ventilation following exposure to chronic hypoxia in conscious rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2006;291(5):R1449-56.
2006: Kenichi Kitani; Setsuko Kanai; Kyoko Miyasaka; Maria-Cristina Carrillo; Gwen O Ivy
The necessity of having a proper dose of (-)deprenyl (D) to prolong the life spans of rats explains discrepancies among different studies in the past.
Annals of the New York Academy of Sciences 2006;1067():375-82.
2005: Mani Vessal; Chandrasagar B Dugani; Dianand A Solomon; W McIntyre Burnham; Gwen O Ivy
Might astrocytes play a role in maintaining the seizure-prone state?
Brain research 2005;1044(2):190-6.
2005: Kenichi Kitani; Setsuko Kanai; Kyoko Miyasaka; Maria-Cristina Carrillo; Gwen O Ivy
Dose-dependency of life span prolongation of F344/DuCrj rats injected with (-)deprenyl.
Biogerontology 2005;6(5):297-302.
2004: Mani Vessal; Chandrasagar B Dugani; Dianand A Solomon; W McIntyre Burnham; Gwen O Ivy
Astrocytic proliferation in the piriform cortex of amygdala-kindled subjects: a quantitative study in partial versus fully kindled brains.
Brain research 2004;1022(1-2):47-53.
2002: Kenichi Kitani; Chiyoko Minami; Ken-ichi Isobe; Kayoko Maehara; Setsuko Kanai; Gwen O Ivy; Maria-Cristina Carrillo
Why (--)deprenyl prolongs survivals of experimental animals: increase of anti-oxidant enzymes in brain and other body tissues as well as mobilization of various humoral factors may lead to systemic anti-aging effects.
Mechanisms of ageing and development 2002;123(8):1087-100.
2002: Kenichi Kitani; Chiyoko Minami; Takako Yamamoto; Setsuko Kanai; Gwen O Ivy; Maria-Cristina Carrillo
Pharmacological interventions in aging and age-associated disorders: potentials of propargylamines for human use.
Annals of the New York Academy of Sciences 2002;959():295-307.
2001: Stéphanie A Backman; Vuk Stambolic; Akira Suzuki; James S J Haight; Andrew Elia; Jim Pretorius; Ming Tsao; Patrick Shannon; Brad Bolon; Gwen O Ivy; Tak W Mak
Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease.
Nature genetics 2001;29(4):396-403.
2001: Kenichi Kitani; Chiyoko Minami; Takako Yamamoto; Wakako Maruyama; Setsuko Kanai; Gwen O Ivy; Maria-Cristina Carrillo
Do antioxidant strategies work against aging and age-associated disorders? Propargylamines: a possible antioxidant strategy.
Annals of the New York Academy of Sciences 2001;928():248-60.
2000: Maria-Cristina Carrillo; Setsuko Kanai; Kenichi Kitani; Gwen O Ivy
A high dose of long term treatment with deprenyl loses its effect on antioxidant enzyme activities as well as on survivals of Fischer-344 rats.
Life sciences 2000;67(21):2539-48.
2000: Kenichi Kitani; Chiyoko Minami; Wakako Maruyama; Setsuko Kanai; Gwen O Ivy; Maria-Cristina Carrillo
Common properties for propargylamines of enhancing superoxide dismutase and catalase activities in the dopaminergic system in the rat: implications for the life prolonging effect of (-)deprenyl.
Journal of neural transmission. Supplementum 2000;(60):139-56.
1999: Kenichi Kitani; Setsuko Kanai; Gwen O Ivy; Maria-Cristina Carrillo
Pharmacological modifications of endogenous antioxidant enzymes with special reference to the effects of deprenyl: a possible antioxidant strategy.
Mechanisms of ageing and development 1999;111(2-3):211-21.
1998: Kenichi Kitani; Setsuko Kanai; Gwen O Ivy; Maria-Cristina Carrillo
Assessing the effects of deprenyl on longevity and antioxidant defenses in different animal models.
Annals of the New York Academy of Sciences 1998;854():291-306.
1997: J G Mielke; Michael Murphy; J Maritz; K M Bengualid; Gwen O Ivy
Chloroquine administration in mice increases beta-amyloid immunoreactivity and attenuates kainate-induced blood-brain barrier dysfunction.
Neuroscience letters 1997;227(3):169-72.
1996: Moshe Khurgel; Gwen O Ivy
Astrocytes in kindling: relevance to epileptogenesis.
Epilepsy research 1996;26(1):163-75.
1996: D B Mendis; Gwen O Ivy; Ian R Brown
SC1, a brain extracellular matrix glycoprotein related to SPARC and follistatin, is expressed by rat cerebellar astrocytes following injury and during development.
Brain research 1996;730(1-2):95-106.
1996: J T Rick; Michael Murphy; Gwen O Ivy; Norton W Milgram
Short intertrial intervals impair water maze performance in old Fischer 344 rats.
The journals of gerontology. Series A, Biological sciences and medical sciences 1996;51(4):B253-60.
1996: K Kitani; K Miyasaka; S Kanai; M C Carrillo; Gwen O Ivy
Upregulation of antioxidant enzyme activities by deprenyl. Implications for life span extension.
Annals of the New York Academy of Sciences 1996;786():391-409.
1996: Gwen O Ivy; R Roopsingh; S Kanai; M Ohta; Y Sato; K Kitani
Leupeptin causes an accumulation of lipofuscin-like substances and other signs of aging in kidneys of young rats: further evidence for the protease inhibitor model of aging.
Annals of the New York Academy of Sciences 1996;786():12-23.
1996: Elizabeth Head; J Hartley; A M Kameka; R Mehta; Gwen O Ivy; WW Ruehl; Norton W Milgram
The effects of L-deprenyl on spatial short term memory in young and aged dogs.
Progress in neuro-psychopharmacology & biological psychiatry 1996;20(3):515-30.
1996: Moshe Khurgel; A C Koo; Gwen O Ivy
Selective ablation of astrocytes by intracerebral injections of alpha-aminoadipate.
Glia 1996;16(4):351-8.
1996: M C Carrillo; K Kitani; Setsuko Kanai; Y Sato; Gwen O Ivy; K Miyasaka
Long term treatment with (-)deprenyl reduces the optimal dose as well as the effective dose range for increasing antioxidant enzyme activities in old mouse brain.
Life sciences 1996;59(13):1047-57.
1995: IA Paterson; BA Davis; D A Durden; Augusto V Juorio; Peter H Yu; Gwen O Ivy; W Milgram; A Mendonca; P Wu; Alan A Boulton
Inhibition of MAO-B by (-)-deprenyl alters dopamine metabolism in the macaque (Macaca facicularis) brain.
Neurochemical research 1995;20(12):1503-10.
1995: Michael Murphy; J T Rick; Norton W Milgram; Gwen O Ivy
A simple and rapid test of sensorimotor function in the aged rat.
Neurobiology of learning and memory 1995;64(2):181-6.
1995: Norton W Milgram; Gwen O Ivy; Michael Murphy; Elizabeth Head; P H Wu; WW Ruehl; P H Yu; D A Durden; B A Davis; A A Boulton
Effects of chronic oral administration of L-deprenyl in the dog.
Pharmacology, biochemistry, and behavior 1995;51(2-3):421-8.
1995: Moshe Khurgel; R C Switzer; G Campbell Teskey; A E Spiller; R J Racine; Gwen O Ivy
Activation of astrocytes during epileptogenesis in the absence of neuronal degeneration.
Neurobiology of disease 1995;2(1):23-35.
1995: R R Hampton; D F Sherry; S J Shettleworth; Moshe Khurgel; Gwen O Ivy
Hippocampal volume and food-storing behavior are related in parids.
Brain, behavior and evolution 1995;45(1):54-61.
1994: K Kitani; S Kanai; M C Carrillo; Gwen O Ivy
(-)Deprenyl increases the life span as well as activities of superoxide dismutase and catalase but not of glutathione peroxidase in selective brain regions in Fischer rats.
Annals of the New York Academy of Sciences 1994;717():60-71.
1994: Gwen O Ivy; J T Rick; Michael Murphy; Elizabeth Head; C Reid; Norton W Milgram
Effects of L-deprenyl on manifestations of aging in the rat and dog.
Annals of the New York Academy of Sciences 1994;717():45-59.
1994: M C Carrillo; K Kitani; Setsuko Kanai; Y Sato; K Miyasaka; Gwen O Ivy
The effect of a long term (6 months) treatment with (-)deprenyl on antioxidant enzyme activities in selective brain regions in old female Fischer 344 rats.
Biochemical pharmacology 1994;47(8):1333-8.
1994: M C Carrillo; Gwen O Ivy; Norton W Milgram; Elizabeth Head; P Wu; K Kitani
(-)Deprenyl increases activities of superoxide dismutase (SOD) in striatum of dog brain.
Life sciences 1994;54(20):1483-9.
1994: M C Carrillo; K Kitani; Setsuko Kanai; Y Sato; K Miyasaka; Gwen O Ivy
(-)deprenyl increases activities of superoxide dismutase and catalase in certain brain regions in old male mice.
Life sciences 1994;54(14):975-81.
1993: Michael Murphy; P H Wu; Norton W Milgram; Gwen O Ivy
Monoamine oxidase inhibition by L-deprenyl depends on both sex and route of administration in the rat.
Neurochemical research 1993;18(12):1299-304.
1993: Norton W Milgram; Gwen O Ivy; Elizabeth Head; Michael Murphy; P H Wu; WW Ruehl; P H Yu; D A Durden; B A Davis; IA Paterson
The effect of L-deprenyl on behavior, cognitive function, and biogenic amines in the dog.
Neurochemical research 1993;18(12):1211-9.
1993: M C Carrillo; Setsuko Kanai; Y Sato; M Nokubo; Gwen O Ivy; K Kitani
The optimal dosage of (-)deprenyl for increasing superoxide dismutase activities in several brain regions decreases with age in male Fischer 344 rats.
Life sciences 1993;52(24):1925-34.
1993: K Kitani; Setsuko Kanai; Y Sato; M Ohta; Gwen O Ivy; M C Carrillo
Chronic treatment of (-)deprenyl prolongs the life span of male Fischer 344 rats. Further evidence.
Life sciences 1993;52(3):281-8.
1992: Gwen O Ivy
Protease inhibition causes some manifestations of aging and Alzheimer's disease in rodent and primate brain.
Annals of the New York Academy of Sciences 1992;674():89-102.
1992: M C Carrillo; Setsuko Kanai; Y Sato; Gwen O Ivy; K Kitani
Sequential changes in activities of superoxide dismutase and catalase in brain regions and liver during (-)deprenyl infusion in male rats.
Biochemical pharmacology 1992;44(11):2185-9.
1992: Moshe Khurgel; R J Racine; Gwen O Ivy
Kindling causes changes in the composition of the astrocytic cytoskeleton.
Brain research 1992;592(1-2):338-42.
1992: M C Carrillo; Setsuko Kanai; M Nokubo; Gwen O Ivy; Y Sato; K Kitani
(-)Deprenyl increases activities of superoxide dismutase and catalase in striatum but not in hippocampus: the sex and age-related differences in the optimal dose in the rat.
Experimental neurology 1992;116(3):286-94.
1992: C F Landry; Gwen O Ivy; Ian R Brown
Effect of a discrete dorsal forebrain lesion in the rat on the expression of neuronal and glial-specific genes: induction of calmodulin, NF-L, SC1, and GFAP mRNA.
Journal of neuroscience research 1992;32(2):280-9.
1992: Gwen O Ivy
Protease inhibitors as a model for NCL disease, with special emphasis on the infantile and adult forms.
American journal of medical genetics 1992;42(4):555-60.
1992: M C Carrillo; K Kitani; Setsuko Kanai; Y Sato; Gwen O Ivy
The ability of (-)deprenyl to increase superoxide dismutase activities in the rat is tissue and brain region selective.
Life sciences 1992;50(25):1985-92.
1992: M Shibata; Setsuko Kanai; Gwen O Ivy; M Ohta; Mikio Asakura; A Aoba; K Hasegawa; K Kitani
Intraventricular infusion of leupeptin decreases Bmax of the D2 receptor in the striatum of young rats.
Life sciences 1992;50(19):1451-7.
1991: Norton W Milgram; T Yearwood; Moshe Khurgel; Gwen O Ivy; R Racine
Changes in inhibitory processes in the hippocampus following recurrent seizures induced by systemic administration of kainic acid.
Brain research 1991;551(1-2):236-46.
1990: C F Landry; Gwen O Ivy; Ian R Brown
Developmental expression of glial fibrillary acidic protein mRNA in the rat brain analyzed by in situ hybridization.
Journal of neuroscience research 1990;25(2):194-203.
1990: Norton W Milgram; R J Racine; P Nellis; A Mendonca; Gwen O Ivy
Maintenance on L-deprenyl prolongs life in aged male rats.
Life sciences 1990;47(5):415-20.
1989: C F Landry; Gwen O Ivy; Robert J Dunn; Alexander Marks; Ian R Brown
Expression of the gene encoding the beta-subunit of S-100 protein in the developing rat brain analyzed by in situ hybridization.
Brain research. Molecular brain research 1989;6(4):251-62.
1989: Gwen O Ivy; K Kitani; Yasuo Ihara
Anomalous accumulation of tau and ubiquitin immunoreactivities in rat brain caused by protease inhibition and by normal aging: a clue to PHF pathogenesis?
Brain research 1989;498(2):360-5.
1989: K Kitani; M Ohta; Setsuko Kanai; M Nokubo; Y Sato; K Otsubo; Gwen O Ivy
Morphological, physiological and biochemical alterations in livers of rodents induced by protease inhibitors: a comparison with old livers.
Advances in experimental medicine and biology 1989;266():75-92.