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Yoichiro Iwakura

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Masaki Katayama; Daisuke Kawabata; Takao Fujii; Motomu Hashimoto; Yoichiro Iwakura; Koichiro Ohmura; Chikashi Terao; Hajime Yoshifuji; Naoichiro Yukawa; Tsuneyo Mimori
Neutrophils are essential as a source of IL-17 in the effector phase of arthritis.
Sunao Sugita; Yoshihiko Usui; Ayano Imai; Kikuo Isoda; Masataka Ito; Yoichiro Iwakura; Yuko Kawazoe; Manabu Mochizuki
Mature Dendritic Cell Suppression by IL-1 Receptor Antagonist on Retinal Pigment Epithelium Cells.
Aoi Akitsu; Yoichiro Iwakura
[IL-17 family and receptor pathway].

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All Publications

2013: Masaki Katayama; Daisuke Kawabata; Takao Fujii; Motomu Hashimoto; Yoichiro Iwakura; Koichiro Ohmura; Chikashi Terao; Hajime Yoshifuji; Naoichiro Yukawa; Tsuneyo Mimori
Neutrophils are essential as a source of IL-17 in the effector phase of arthritis.
PloS one 2013;8(5):e62231.
2013: Sunao Sugita; Yoshihiko Usui; Ayano Imai; Kikuo Isoda; Masataka Ito; Yoichiro Iwakura; Yuko Kawazoe; Manabu Mochizuki
Mature Dendritic Cell Suppression by IL-1 Receptor Antagonist on Retinal Pigment Epithelium Cells.
Investigative ophthalmology & visual science 2013;54(5):3240-9.
2012: Aoi Akitsu; Yoichiro Iwakura
[IL-17 family and receptor pathway].
Nihon rinsho. Japanese journal of clinical medicine 2012;70 Suppl 8():207-11.
2012: Daisuke Yamanaka; Rui Tada; Yoshiyuki Adachi; Ken-ichi Ishibashi; Yoichiro Iwakura; Masuro Motoi; Naohito Ohno
Agaricus brasiliensis-derived β-glucans exert immunoenhancing effects via a dectin-1-dependent pathway.
International immunopharmacology 2012;14(3):311-9.
2012: Yoshinobu Okamoto; Manabu Fujimoto; Yasuhito Hamaguchi; Minoru Hasegawa; Doanh Le Huu; Yoichiro Iwakura; Takashi Matsushita; Kazuhiko Takehara
Potential roles of interleukin-17A in the development of skin fibrosis in mice.
Arthritis and rheumatism 2012;64(11):3726-35.
2012: Tomoyuki Yoshida; Tomoko Shiroshima; Takeshi Uemura; Misato Yasumura; Xigui Chen; Yoichiro Iwakura; Sung-Jin Lee; Masayoshi Mishina
Interleukin-1 receptor accessory protein organizes neuronal synaptogenesis as a cell adhesion molecule.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(8):2588-600.
2012: Nozomi Satou; Hiroyuki Tanaka; Yasuo Endo; Masahiro Hiratsuka; Kenji Ishihara; Yoichiro Iwakura; Warren J Leonard; Saburo Saito; Noriyasu Hirasawa
Induction of thymic stromal lymphopoietin production by xylene and exacerbation of picryl chloride-induced allergic inflammation in mice.
International archives of allergy and immunology 2012;157(2):194-201.
2012: Kiyotetsu Oshiro; Masayuki Umemura; Catherine Uyttenhove; Susumu Nakae; Tadashi Nishimaki; Takeshi Arakawa; Mamoru Harada; Kyoko Inagaki-Ohara; Yoichiro Iwakura; Hideyasu Kohama; Goro Matsuzaki
Interleukin-17A is involved in enhancement of tumor progression in murine intestine.
Immunobiology 2012;217(1):54-60.
2011: Kazumasa Yokoyama; Naosuke Hoshina; Yoichiro Iwakura; Shigeru Kakuta; Masaharu Kotani; Takanobu Nakazawa; Yasushi Shimoda; Katsuko Sudo; Tohru Tezuka; Kazutada Watanabe; Tadashi Yamamoto
NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons.
The EMBO journal 2011;30(23):4739-54.
2011: Yoshihiro Hayakawa; Yoichiro Iwakura; Marimo Sato-Matsushita; Hideaki Tahara; Kazuyoshi Takeda; Tatsuro Irimura
Early activation and interferon-γ production of tumor-infiltrating mature CD27 high natural killer cells.
Cancer science 2011;102(11):1967-71.
2011: Mingli Xu; Koji Yasutomo; Yukino Chiba; Daniel J Cua; Koji Fujita; Yoichiro Iwakura; Masahiko Kuroda; Izuru Mizoguchi; Junichiro Mizuguchi; Noriko Morishima; Takayuki Yoshimoto
Regulation of the development of acute hepatitis by IL-23 through IL-22 and IL-17 production.
European journal of immunology 2011;41(10):2828-39.
2011: Chisato Wakabayashi; Yuji Kiyama; Hiroshi Kunugi; Toshiya Manabe; Yoichiro Iwakura
Age-dependent regulation of depression-like behaviors through modulation of adrenergic receptor α₁A subtype expression revealed by the analysis of interleukin-1 receptor antagonist knockout mice.
Neuroscience 2011;192():475-84.
2011: Tomoyuki Yoshida; Yoichiro Iwakura; Sung-Jin Lee; Moonjin Ra; Ryo Taguchi; Takeshi Uemura; Misato Yasumura; Masayoshi Mishina
IL-1 receptor accessory protein-like 1 associated with mental retardation and autism mediates synapse formation by trans-synaptic interaction with protein tyrosine phosphatase δ.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(38):13485-99.
2011: Satoshi Itoh; Yoichiro Iwakura; Naoki Kajiwara; Naoyuki Kimura; Susumu Nakae; Aya Nambu; Ko Okumura; Robert C Robbins; Hirohisa Saito; Eri Shimura; Lawrence Steinman; Katsuko Sudo; Jeffrey B Velotta; Xi Wang; Hideo Adachi; Robert C Axtell; Yongquan Gong; Michael P Fischbein
Interleukin-17 accelerates allograft rejection by suppressing regulatory T cell expansion.
Circulation 2011;124(11 Suppl):S187-96.
2011: Yoichiro Iwakura; Harumichi Ishigame; Shinobu Saijo; Susumu Nakae
Functional specialization of interleukin-17 family members.
Immunity 2011;34(2):149-62.
2011: Yosuke Shikama; Toshinobu Kuroishi; Yasuhiro Nagai; Yoichiro Iwakura; Hidetoshi Shimauchi; Haruhiko Takada; Shunji Sugawara; Yasuo Endo
Muramyldipeptide augments the actions of lipopolysaccharide in mice by stimulating macrophages to produce pro-IL-1β and by down-regulation of the suppressor of cytokine signaling 1 (SOCS1).
Innate immunity 2011;17(1):3-15.
2010: Utako Ikeda; Daiko Wakita; Takayuki Ohkuri; Kenji Chamoto; Hidemitsu Kitamura; Yoichiro Iwakura; Takashi Nishimura
1α,25-Dihydroxyvitamin D3 and all-trans retinoic acid synergistically inhibit the differentiation and expansion of Th17 cells.
Immunology letters 2010;134(1):7-16.
2010: Young-Mi Lee; Noriyuki Fujikado; Hiroko Manaka; Hisataka Yasuda; Yoichiro Iwakura
IL-1 plays an important role in the bone metabolism under physiological conditions.
International immunology 2010;22(10):805-16.
2010: Akiko Nakajima; Taizo Matsuki; Mayumi Komine; Akihiko Asahina; Reiko Horai; Susumu Nakae; Harumichi Ishigame; Shigeru Kakuta; Shinobu Saijo; Yoichiro Iwakura
TNF, but not IL-6 and IL-17, is crucial for the development of T cell-independent psoriasis-like dermatitis in Il1rn-/- mice.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(3):1887-93.
2010: Daiko Wakita; Kentaro Sumida; Yoichiro Iwakura; Hiroyoshi Nishikawa; Takayuki Ohkuri; Kenji Chamoto; Hidemitsu Kitamura; Takashi Nishimura
Tumor-infiltrating IL-17-producing gammadelta T cells support the progression of tumor by promoting angiogenesis.
European journal of immunology 2010;40(7):1927-37.
2010: Motohiko Kadoki; Byung-Il Choi; Yoichiro Iwakura
The mechanism of LPS-induced HIV type I activation in transgenic mouse macrophages.
International immunology 2010;22(6):469-78.
2010: Shigeru Ashino; Daiko Wakita; Yasuo Shiohama; Yoichiro Iwakura; Kenji Chamoto; Takayuki Ohkuri; Hidemitsu Kitamura; Takashi Nishimura
A T(h)17-polarized cell population that has infiltrated the lung requires cells that convert to IFN-{gamma} production in order to induce airway hyperresponsiveness.
International immunology 2010;22(6):503-13.
2010: Shinobu Saijo; Satoshi Ikeda; Keiko Yamabe; Shigeru Kakuta; Harumichi Ishigame; Aoi Akitsu; Noriyuki Fujikado; Toshimasa Kusaka; Sachiko Kubo; Soo-hyun Chung; Ryohei Komatsu; Noriko Miura; Yoshiyuki Adachi; Naohito Ohno; Kazutoshi Shibuya; Natsuo Yamamoto; Kazuyoshi Kawakami; Sho Yamasaki; Takashi Saito; Shizuo Akira; Yoichiro Iwakura
Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans.
Immunity 2010;32(5):681-91.
2010: Yuko Okamoto Yoshida; Masayuki Umemura; Ayano Yahagi; Rebecca L O'Brien; Koichi Ikuta; Kenji Kishihara; Hiromitsu Hara; Susumu Nakae; Yoichiro Iwakura; Goro Matsuzaki
Essential role of IL-17A in the formation of a mycobacterial infection-induced granuloma in the lung.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(8):4414-22.
2010: Hiroaki Okae; Yoichiro Iwakura
Neural tube defects and impaired neural progenitor cell proliferation in Gbeta1-deficient mice.
Developmental dynamics : an official publication of the American Association of Anatomists 2010;239(4):1089-101.
2010: Thomas Henry; Girish S Kirimanjeswara; Thomas Ruby; Jonathan W Jones; Kaitian Peng; Magali Perret; Lena Ho; John-Demian Sauer; Yoichiro Iwakura; Dennis W Metzger; Denise M Monack
Type I IFN signaling constrains IL-17A/F secretion by gammadelta T cells during bacterial infections.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(7):3755-67.
2010: Kikuo Isoda; Taizo Matsuki; Harumi Kondo; Yoichiro Iwakura; Fumitaka Ohsuzu
Deficiency of interleukin-1 receptor antagonist induces aortic valve disease in BALB/c mice.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(4):708-15.
2010: Soo-Hyun Chung; Keisuke Seki; Byung-Il Choi; Keiko B Kimura; Akihiko Ito; Noriyuki Fujikado; Shinobu Saijo; Yoichiro Iwakura
CXC chemokine receptor 4 expressed in T cells plays an important role in the development of collagen-induced arthritis.
Arthritis research & therapy 2010;12(5):R188.
2009: Sachiko Taniguchi; Takanobu Nakazawa; Asami Tanimura; Yuji Kiyama; Tohru Tezuka; Ayako M Watabe; Norikazu Katayama; Kazumasa Yokoyama; Takafumi Inoue; Hiroko Izumi-Nakaseko; Shigeru Kakuta; Katsuko Sudo; Yoichiro Iwakura; Hisashi Umemori; Takeshi Inoue; Niall P Murphy; Kouichi Hashimoto; Masanobu Kano; Toshiya Manabe; Tadashi Yamamoto
Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour.
The EMBO journal 2009;28(23):3717-29.
2009: Naoko Okiyama; Takahiko Sugihara; Yoichiro Iwakura; Hiroo Yokozeki; Nobuyuki Miyasaka; Hitoshi Kohsaka
Therapeutic effects of interleukin-6 blockade in a murine model of polymyositis that does not require interleukin-17A.
Arthritis and rheumatism 2009;60(8):2505-12.
2009: Yuko Ohtaki; Kouji Yamaguchi; Zhiqian Yu; Hiroyuki Kumamoto; Hidetoshi Shimauchi; Yoichiro Iwakura; Shunji Sugawara; Yasuo Endo
Hepatic platelet accumulation in Fas-mediated hepatitis in mice.
International immunopharmacology 2009;9(9):1071-8.
2009: Toshinobu Kuroishi; Masayuki Kinbara; Naoki Sato; Yukinori Tanaka; Yasuhiro Nagai; Yoichiro Iwakura; Yasuo Endo; Shunji Sugawara
Biotin status affects nickel allergy via regulation of interleukin-1beta production in mice.
The Journal of nutrition 2009;139(5):1031-6.
2009: Akane Inoue; Kiyoko Setoguchi; Yosuke Matsubara; Kumiko Okada; Nozomi Sato; Yoichiro Iwakura; Osamu Higuchi; Yuji Yamanashi
Dok-7 activates the muscle receptor kinase MuSK and shapes synapse formation.
Science signaling 2009;2(59):ra7.
2009: Mitsuhiro Yoneda; Toru Suzuki; Takahisa Nakamura; Rieko Ajima; Yutaka Yoshida; Shigeru Kakuta; Sudo Katsuko; Yoichiro Iwakura; Makoto Shibutani; Kunitoshi Mitsumori; Jun Yokota; Tadashi Yamamoto
Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinoma.
Cancer science 2009;100(2):225-32.
2009: Harumichi Ishigame; Shigeru Kakuta; Takeshi Nagai; Motohiko Kadoki; Aya Nambu; Yutaka Komiyama; Noriyuki Fujikado; Yuko Tanahashi; Aoi Akitsu; Hayato Kotaki; Katsuko Sudo; Susumu Nakae; Chihiro Sasakawa; Yoichiro Iwakura
Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses.
Immunity 2009;30(1):108-19.
2008: Yoichiro Iwakura; Susumu Nakae; Shinobu Saijo; Harumichi Ishigame
The roles of IL-17A in inflammatory immune responses and host defense against pathogens.
Immunological reviews 2008;226():57-79.
2008: Dai Chida; O Hashimoto; M Kuwahara; Hiroshi Sagara; T Osaka; H Tsubone; Yoichiro Iwakura
Increased fat:carbohydrate oxidation ratio in Il1ra (-/-) mice on a high-fat diet is associated with increased sympathetic tone.
Diabetologia 2008;51(9):1698-706.
2008: Naoto Kubota; Tetsuya Kubota; Shinsuke Itoh; Hiroki Kumagai; Hideki Kozono; Iseki Takamoto; Tomoka Mineyama; Hitomi Ogata; Kumpei Tokuyama; Miho Ohsugi; Takayoshi Sasako; Masao Moroi; Kaoru Sugi; Shigeru Kakuta; Yoichiro Iwakura; Tetsuo Noda; Shin Ohnishi; Ryozo Nagai; Kazuyuki Tobe; Yasuo Terauchi; Kohjiro Ueki; Takashi Kadowaki
Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding.
Cell metabolism 2008;8(1):49-64.
2008: Masaki Tajima; Daiko Wakita; Daisuke Noguchi; Kenji Chamoto; Zhang Yue; Kazunori Fugo; Harumichi Ishigame; Yoichiro Iwakura; Hidemitsu Kitamura; Takashi Nishimura
IL-6-dependent spontaneous proliferation is required for the induction of colitogenic IL-17-producing CD8+ T cells.
The Journal of experimental medicine 2008;205(5):1019-27.
2008: Kiwamu Nakamura; Akiko Miyazato; Gang Xiao; Masumitsu Hatta; Ken Inden; Tetsuji Aoyagi; Kohei Shiratori; Kiyoshi Takeda; Shizuo Akira; Shinobu Saijo; Yoichiro Iwakura; Yoshiyuki Adachi; Naohito Ohno; Kazuo Suzuki; Jiro Fujita; Mitsuo Kaku; Kazuyoshi Kawakami
Deoxynucleic acids from Cryptococcus neoformans activate myeloid dendritic cells via a TLR9-dependent pathway.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(6):4067-74.
2008: Miho Ohsugi; Kenjiro Adachi; Reiko Horai; Shigeru Kakuta; Katsuko Sudo; Hayato Kotaki; Noriko Tokai-Nishizumi; Hiroshi Sagara; Yoichiro Iwakura; Tadashi Yamamoto
Kid-mediated chromosome compaction ensures proper nuclear envelope formation.
Cell 2008;132(5):771-82.
2008: Akinori Okumura; Takeshi Saito; Isao Otani; Kazuo Kojima; Yasunori Yamada; Akiko Ishida-Okawara; Katsuyoshi Nakazato; Masahide Asano; Kiichi Kanayama; Yoichiro Iwakura; Kazuo Suzuki; Satoshi Yamagoe
Suppressive role of leukocyte cell-derived chemotaxin 2 in mouse anti-type II collagen antibody-induced arthritis.
Arthritis and rheumatism 2008;58(2):413-21.
2008: Noriyuki Fujikado; Shinobu Saijo; Tomo Yonezawa; Kazusuke Shimamori; Akina Ishii; Sho Sugai; Hayato Kotaki; Katsuko Sudo; Masato Nose; Yoichiro Iwakura
Dcir deficiency causes development of autoimmune diseases in mice due to excess expansion of dendritic cells.
Nature medicine 2008;14(2):176-80.
2008: Hiromitsu Teruya; Mariko Tomita; Masachika Senba; Chie Ishikawa; Maki Tamayose; Akiko Miyazato; Satomi Yara; Yuetsu Tanaka; Yoichiro Iwakura; Jiro Fujita; Naoki Mori
Human T-cell leukemia virus type I infects human lung epithelial cells and induces gene expression of cytokines, chemokines and cell adhesion molecules.
Retrovirology 2008;5():86.
2007: Dai Chida; Yoichiro Iwakura
Peripheral TNFalpha, but not peripheral IL-1, requires endogenous IL-1 or TNFalpha induction in the brain for the febrile response.
Biochemical and biophysical research communications 2007;364(4):765-70.
2007: Yuko Kayasuga; Shuichi Chiba; Masatoshi Suzuki; Takefumi Kikusui; Takashi Matsuwaki; Keitaro Yamanouchi; Hayato Kotaki; Reiko Horai; Yoichiro Iwakura; Masugi Nishihara
Alteration of behavioural phenotype in mice by targeted disruption of the progranulin gene.
Behavioural brain research 2007;185(2):110-8.
2007: Dai Chida; Shinichi Nakagawa; So Nagai; Hiroshi Sagara; Harumi Katsumata; Toshihiro Imaki; Harumi Suzuki; Fumiko Mitani; Tadashi Ogishima; Chikara Shimizu; Hayato Kotaki; Shigeru Kakuta; Katsuko Sudo; Takao Koike; Mitsumasa Kubo; Yoichiro Iwakura
Melanocortin 2 receptor is required for adrenal gland development, steroidogenesis, and neonatal gluconeogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(46):18205-10.
2007: Shin-ichiro Kina; Tohru Tezuka; Shinji Kusakawa; Yasushi Kishimoto; Shigeyuki Kakizawa; Koichi Hashimoto; Miho Ohsugi; Yuji Kiyama; Reiko Horai; Katsuko Sudo; Shigeru Kakuta; Yoichiro Iwakura; Masamitsu Iino; Masanobu Kano; Toshiya Manabe; Tadashi Yamamoto
Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression.
The European journal of neuroscience 2007;26(8):2269-78.
2007: Teruo Kaiga; Marimo Sato-Matsushita; Hide Kaneda; Yoichiro Iwakura; Tadatoshi Takayama; Hideaki Tahara
Systemic administration of IL-23 induces potent antitumor immunity primarily mediated through Th1-type response in association with the endogenously expressed IL-12.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(12):7571-80.
2007: Maho Ishida; Jae-hyek Choi; Keiji Hirabayashi; Takashi Matsuwaki; Masatoshi Suzuki; Keitaro Yamanouchi; Reiko Horai; Katsuko Sudo; Yoichiro Iwakura; Masugi Nishihara
Reproductive phenotypes in mice with targeted disruption of the 20alpha-hydroxysteroid dehydrogenase gene.
The Journal of reproduction and development 2007;53(3):499-508.
2007: Thiagarajan Venkataraman; Maikel Valdes; Rachel Elsby; Shigeru Kakuta; Gisela Caceres; Shinobu Saijo; Yoichiro Iwakura; Glen N Barber
Loss of DExD/H box RNA helicase LGP2 manifests disparate antiviral responses.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(10):6444-55.
2007: Takahiko Sugihara; Chiyoko Sekine; Takashi Nakae; Kuniko Kohyama; Masayoshi Harigai; Yoichiro Iwakura; Yoh Matsumoto; Nobuyuki Miyasaka; Hitoshi Kohsaka
A new murine model to define the critical pathologic and therapeutic mediators of polymyositis.
Arthritis and rheumatism 2007;56(4):1304-14.
2007: Masayuki Umemura; Ayano Yahagi; Satoru Hamada; Mst Dilara Begum; Hisami Watanabe; Kazuyoshi Kawakami; Takashi Suda; Katsuko Sudo; Susumu Nakae; Yoichiro Iwakura; Goro Matsuzaki
IL-17-mediated regulation of innate and acquired immune response against pulmonary Mycobacterium bovis bacille Calmette-Guerin infection.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(6):3786-96.
2007: Kenjiro Adachi; Chie Soeta-Saneyoshi; Hiroshi Sagara; Yoichiro Iwakura
Crucial role of Bysl in mammalian preimplantation development as an integral factor for 40S ribosome biogenesis.
Molecular and cellular biology 2007;27(6):2202-14.
2007: Keiji Hirota; Motomu Hashimoto; Hiroyuki Yoshitomi; Satoshi Tanaka; Takashi Nomura; Tomoyuki Yamaguchi; Yoichiro Iwakura; Noriko Sakaguchi; Shimon Sakaguchi
T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis.
The Journal of experimental medicine 2007;204(1):41-7.
2007: Kiwamu Nakamura; Takeshi Kinjo; Shinobu Saijo; Akiko Miyazato; Yoshiyuki Adachi; Naohito Ohno; Jiro Fujita; Mitsuo Kaku; Yoichiro Iwakura; Kazuyoshi Kawakami
Dectin-1 is not required for the host defense to Cryptococcus neoformans.
Microbiology and immunology 2007;51(11):1115-9.
2007: Shinobu Saijo; Noriyuki Fujikado; Takahisa Furuta; Soo-hyun Chung; Hayato Kotaki; Keisuke Seki; Katsuko Sudo; Shizuo Akira; Yoshiyuki Adachi; Naohito Ohno; Takeshi Kinjo; Kiwamu Nakamura; Kazuyoshi Kawakami; Yoichiro Iwakura
Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans.
Nature immunology 2007;8(1):39-46.
2007: Naomi Tsurutani; Jiro Yasuda; Naoki Yamamoto; Byung-Il Choi; Motohiko Kadoki; Yoichiro Iwakura
Nuclear import of the preintegration complex is blocked upon infection by human immunodeficiency virus type 1 in mouse cells.
Journal of virology 2007;81(2):677-88.
2006: kojiro sato; Ayako Suematsu; Kazuo Okamoto; Akira Yamaguchi; Yasuyuki Morishita; Yuho Kadono; Sakae Tanaka; Tatsuhiko Kodama; Shizuo Akira; Yoichiro Iwakura; Daniel J Cua; Hiroshi Takayanagi
Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction.
The Journal of experimental medicine 2006;203(12):2673-82.
2006: Masato Murakami; Shinobu Iwai; Sachie Hiratsuka; Mai Yamauchi; Kazuhide Nakamura; Yoichiro Iwakura; Masabumi Shibuya
Signaling of vascular endothelial growth factor receptor-1 tyrosine kinase promotes rheumatoid arthritis through activation of monocytes/macrophages.
Blood 2006;108(6):1849-56.
2006: Takahisa Furuta; Takane Kikuchi; Yoichiro Iwakura; Naohiro Watanabe
Protective roles of mast cells and mast cell-derived TNF in murine malaria.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(5):3294-302.
2006: Kengo Furuichi; Takashi Wada; Yasunori Iwata; Satoshi Kokubo; Akinori Hara; Junya Yamahana; takeshi sugaya; Yoichiro Iwakura; Kouji Matsushima; Masahide Asano; Hitoshi Yokoyama; Shuichi Kaneko
Interleukin-1-dependent sequential chemokine expression and inflammatory cell infiltration in ischemia-reperfusion injury.
Critical care medicine 2006;34(9):2447-55.
2006: Yutaka Komiyama; Susumu Nakae; Taizo Matsuki; Aya Nambu; Harumichi Ishigame; Shigeru Kakuta; Katsuko Sudo; Yoichiro Iwakura
IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(1):566-73.
2006: Kumiko Okada; Akane Inoue; Momoko Okada; Yoji Murata; Shigeru Kakuta; Takafumi Jigami; Sachiko Kubo; Hirokazu Shiraishi; Katsumi Eguchi; Masakatsu Motomura; Tetsu Akiyama; Yoichiro Iwakura; Osamu Higuchi; Yuji Yamanashi
The muscle protein Dok-7 is essential for neuromuscular synaptogenesis.
Science (New York, N.Y.) 2006;312(5781):1802-5.
2006: Takanobu Nakazawa; Shoji Komai; Ayako M Watabe; Yuji Kiyama; MASAHIRO FUKAYA; Fumiko Arima-Yoshida; Reiko Horai; Katsuko Sudo; Kazumi Ebine; Mina Delawary; june goto; Hisashi Umemori; Tohru Tezuka; Yoichiro Iwakura; Masahiko Watanabe; Tadashi Yamamoto; Toshiya Manabe
NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity.
The EMBO journal 2006;25(12):2867-77.
2006: Motomu Shimizu; Mariko Shimamura; Toshiyuki Owaki; Masayuki Asakawa; Koji Fujita; Motoshige Kudo; Yoichiro Iwakura; Yasutaka Takeda; Andrew D Luster; Junichiro Mizuguchi; Takayuki Yoshimoto
Antiangiogenic and antitumor activities of IL-27.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(12):7317-24.
2006: Yoichiro Iwakura; Harumichi Ishigame
The IL-23/IL-17 axis in inflammation.
The Journal of clinical investigation 2006;116(5):1218-22.
2006: Aya Nambu; Susumu Nakae; Yoichiro Iwakura
IL-1beta, but not IL-1alpha, is required for antigen-specific T cell activation and the induction of local inflammation in the delayed-type hypersensitivity responses.
International immunology 2006;18(5):701-12.
2006: Dai Chida; Toshimasa Osaka; Okito Hashimoto; Yoichiro Iwakura
Combined interleukin-6 and interleukin-1 deficiency causes obesity in young mice.
Diabetes 2006;55(4):971-7.
2006: Motoko Kotani; Kazuya Hirata; Shuhei Ogawa; Katsuyoshi Habiro; Yasuo Ishida; Seiichi Tanuma; Reiko Horai; Yoichiro Iwakura; Hidehiro Kishimoto; Ryo Abe
CD28-dependent differentiation into the effector/memory phenotype is essential for induction of arthritis in interleukin-1 receptor antagonist-deficient mice.
Arthritis and rheumatism 2006;54(2):473-81.
2006: Taizo Matsuki; Susumu Nakae; Katsuko Sudo; Reiko Horai; Yoichiro Iwakura
Abnormal T cell activation caused by the imbalance of the IL-1/IL-1R antagonist system is responsible for the development of experimental autoimmune encephalomyelitis.
International immunology 2006;18(2):399-407.
2006: Noriyuki Fujikado; Shinobu Saijo; Yoichiro Iwakura
Identification of arthritis-related gene clusters by microarray analysis of two independent mouse models for rheumatoid arthritis.
Arthritis research & therapy 2006;8(4):R100.
2006: Harumichi Ishigame; Akiko Nakajima; Shinobu Saijo; Yutaka Komiyama; Aya Nambu; Taizo Matsuki; Susumu Nakae; Reiko Horai; Shigeru Kakuta; Yoichiro Iwakura
The role of TNFalpha and IL-17 in the development of excess IL-1 signaling-induced inflammatory diseases in IL-1 receptor antagonist-deficient mice.
Ernst Schering Research Foundation workshop 2006;(56):129-53.
2005: Dai Chida; Toshihiro Imaki; Toshihiro Suda; Yoichiro Iwakura
Involvement of corticotropin-releasing hormone- and interleukin (IL)-6-dependent proopiomelanocortin induction in the anterior pituitary during hypothalamic-pituitary-adrenal axis activation by IL-1alpha.
Endocrinology 2005;146(12):5496-502.
2005: Taizo Matsuki; Kikuo Isoda; Reiko Horai; Akiko Nakajima; Yoshifusa Aizawa; Kazuo Suzuki; Fumitaka Ohsuzu; Yoichiro Iwakura
Involvement of tumor necrosis factor-alpha in the development of T cell-dependent aortitis in interleukin-1 receptor antagonist-deficient mice.
Circulation 2005;112(9):1323-31.
2005: Kikuo Isoda; Shojiro Sawada; Makoto Ayaori; Taizo Matsuki; Reiko Horai; Yutaka Kagata; Koji Miyazaki; Masatoshi Kusuhara; Mitsuyo Okazaki; Osamu Matsubara; Yoichiro Iwakura; Fumitaka Ohsuzu
Deficiency of interleukin-1 receptor antagonist deteriorates fatty liver and cholesterol metabolism in hypercholesterolemic mice.
The Journal of biological chemistry 2005;280(8):7002-9.
2005: Hisaaki Shinohara; Akane Inoue; Noriko Toyama-Sorimachi; Yoshinori Nagai; Tomoharu Yasuda; Hiromi Suzuki; Reiko Horai; Yoichiro Iwakura; Tadashi Yamamoto; Hajime Karasuyama; Kensuke Miyake; Yuji Yamanashi
Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling.
The Journal of experimental medicine 2005;201(3):333-9.
2005: Yoichiro Iwakura
[Interleukin-1 in pathogenesis of rheumatoid arthritis].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 1():153-7.
2004: Reiko Horai; Akiko Nakajima; Katsuyoshi Habiro; Motoko Kotani; Susumu Nakae; Taizo Matsuki; Aya Nambu; Shinobu Saijo; Hayato Kotaki; Katsuko Sudo; Akihiko Okahara; Hidetoshi Tanioka; Toshimi Ikuse; Naoto Ishii; Pamela L Schwartzberg; Ryo Abe; Yoichiro Iwakura
TNF-alpha is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice.
The Journal of clinical investigation 2004;114(11):1603-11.
2004: Kyoko Kagiwada; Dai Chida; Tomoya Sakatani; Masahide Asano; Aya Nambu; Shigeru Kakuta; Yoichiro Iwakura
Interleukin (IL)-6, but not IL-1, induction in the brain downstream of cyclooxygenase-2 is essential for the induction of febrile response against peripheral IL-1alpha.
Endocrinology 2004;145(11):5044-8.
2004: Takayuki Yoshimoto; Keiko Okada; Noriko Morishima; Sadahiro Kamiya; Toshiyuki Owaki; Masayuki Asakawa; Yoichiro Iwakura; Fumio Fukai; Junichiro Mizuguchi
Induction of IgG2a class switching in B cells by IL-27.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(4):2479-85.
2004: Hiroshi Hata; Noriko Sakaguchi; Hiroyuki Yoshitomi; Yoichiro Iwakura; Kenji Sekikawa; Yoshiaki Azuma; Chieko Kanai; Eiko Moriizumi; Takashi Nomura; Takashi Nakamura; Shimon Sakaguchi
Distinct contribution of IL-6, TNF-alpha, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice.
The Journal of clinical investigation 2004;114(4):582-8.
2004: Masayuki Umemura; Takaya Kawabe; Koyo Shudo; Hiroyasu Kidoya; Masayuki Fukui; Masahide Asano; Yoichiro Iwakura; Goro Matsuzaki; Ryu Imamura; Takashi Suda
Involvement of IL-17 in Fas ligand-induced inflammation.
International immunology 2004;16(8):1099-108.
2004: Norihiro Kotani; Masahide Asano; Noboru Inoue; Yoichiro Iwakura; Seiichi Takasaki
Polylactosamine synthesis and branch formation of N-glycans in beta1,4-galactosyltransferase-1-deficient mice.
Archives of biochemistry and biophysics 2004;426(2):258-65.
2004: Kikuo Isoda; Shojiro Sawada; Norio Ishigami; Taizo Matsuki; Koji Miyazaki; Masatoshi Kusuhara; Yoichiro Iwakura; Fumitaka Ohsuzu
Lack of interleukin-1 receptor antagonist modulates plaque composition in apolipoprotein E-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(6):1068-73.
2004: Kazuyoshi Kawakami; Yuki Kinjo; Kaori Uezu; Kazuya Miyagi; Takeshi Kinjo; Satomi Yara; Yoshinobu Koguchi; Akiko Miyazato; Kazutoshi Shibuya; Yoichiro Iwakura; Kiyoshi Takeda; Shizuo Akira; Atsushi Saito
Interferon-gamma production and host protective response against Mycobacterium tuberculosis in mice lacking both IL-12p40 and IL-18.
Microbes and infection / Institut Pasteur 2004;6(4):339-49.
2004: Yuko Ishida; Tsuneo Maegawa; Toshikazu Kondo; Akihiko Kimura; Yoichiro Iwakura; Shinichi Nakamura; Naofumi Mukaida
Essential involvement of IFN-gamma in Clostridium difficile toxin A-induced enteritis.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(5):3018-25.
2004: Kazuto Kurohara; Kouji Komatsu; Tomohiro Kurisaki; Aki Masuda; Naoki Irie; Masahide Asano; Katsuko Sudo; Yo-ichi Nabeshima; Yoichiro Iwakura; Atsuko Sehara-Fujisawa
Essential roles of Meltrin beta (ADAM19) in heart development.
Developmental biology 2004;267(1):14-28.
2004: Yuko Ishida; Toshikazu Kondo; Tatsunori Takayasu; Yoichiro Iwakura; Naofumi Mukaida
The essential involvement of cross-talk between IFN-gamma and TGF-beta in the skin wound-healing process.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(3):1848-55.
2004: Hidenori Ozaki; Kazuaki Nakamura; Jun-ichi Funahashi; Keiko Ikeda; Gen Yamada; Hisashi Tokano; Hiro-Oki Okamura; Ken Kitamura; Shigeaki Muto; Hayato Kotaki; Katsuko Sudo; Reiko Horai; Yoichiro Iwakura; Kiyoshi Kawakami
Six1 controls patterning of the mouse otic vesicle.
Development (Cambridge, England) 2004;131(3):551-62.
2004: Yukage Kobari; Yoshikata Misaki; Kiyoshi Setoguchi; Wenming Zhao; Yoshinori Komagata; Kimito Kawahata; Yoichiro Iwakura; Kazuhiko Yamamoto
T cells accumulating in the inflamed joints of a spontaneous murine model of rheumatoid arthritis become restricted to common clonotypes during disease progression.
International immunology 2004;16(1):131-8.
2003: Susumu Nakae; Aya Nambu; Katsuko Sudo; Yoichiro Iwakura
Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(11):6173-7.
2003: Ai Kariyone; Toshiki Tamura; Hideyuki Kano; Yoichiro Iwakura; Kiyoshi Takeda; Shizuo Akira; Kiyoshi Takatsu
Immunogenicity of Peptide-25 of Ag85B in Th1 development: role of IFN-gamma.
International immunology 2003;15(10):1183-94.
2003: Taizo Matsuki; Reiko Horai; Katsuko Sudo; Yoichiro Iwakura
IL-1 plays an important role in lipid metabolism by regulating insulin levels under physiological conditions.
The Journal of experimental medicine 2003;198(6):877-88.
2003: Masahide Asano; Susumu Nakae; Norihiro Kotani; Naoki Shirafuji; Aya Nambu; Noriyoshi Hashimoto; Hiroto Kawashima; Mayumi Hirose; Masayuki Miyasaka; Seiichi Takasaki; Yoichiro Iwakura
Impaired selectin-ligand biosynthesis and reduced inflammatory responses in beta-1,4-galactosyltransferase-I-deficient mice.
Blood 2003;102(5):1678-85.
2003: Kikuo Isoda; Masaru Shiigai; Norio Ishigami; Taizo Matsuki; Reiko Horai; Kenichirou Nishikawa; Masatoshi Kusuhara; Yasuhiro Nishida; Yoichiro Iwakura; Fumitaka Ohsuzu
Deficiency of interleukin-1 receptor antagonist promotes neointimal formation after injury.
Circulation 2003;108(5):516-8.
2003: Rikako Miyake-Nishijima; Satoshi Iwata; Shinobu Saijo; Hiroshi Kobayashi; Seiji Kobayashi; Akiko Souta-Kuribara; Osamu Hosono; Hiroshi Kawasaki; Hirotoshi Tanaka; Eiji Ikeda; Yasunori Okada; Yoichiro Iwakura; Chikao Morimoto
Role of Crk-associated substrate lymphocyte type in the pathophysiology of rheumatoid arthritis in tax transgenic mice and in humans.
Arthritis and rheumatism 2003;48(7):1890-900.
2003: Susumu Nakae; Shinobu Saijo; Reiko Horai; Katsuko Sudo; Shigeo Mori; Yoichiro Iwakura
IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(10):5986-90.
2003: Susumu Nakae; Yutaka Komiyama; Hiroshi Yokoyama; Aya Nambu; Masaomi Umeda; Michiko Iwase; Ikuo Homma; Katsuko Sudo; Reiko Horai; Masahide Asano; Yoichiro Iwakura
IL-1 is required for allergen-specific Th2 cell activation and the development of airway hypersensitivity response.
International immunology 2003;15(4):483-90.
2003: Susumu Nakae; Yutaka Komiyama; Shosaku Narumi; Katsuko Sudo; Reiko Horai; Yoh-Ichi Tagawa; Kenji Sekikawa; Koji Matsushima; Masahide Asano; Yoichiro Iwakura
IL-1-induced tumor necrosis factor-alpha elicits inflammatory cell infiltration in the skin by inducing IFN-gamma-inducible protein 10 in the elicitation phase of the contact hypersensitivity response.
International immunology 2003;15(2):251-60.
2003: J Tanaka; Takaomi Ishida; B-I Choi; J Yasuda; Toshiki Watanabe; Yoichiro Iwakura
Latent HIV-1 reactivation in transgenic mice requires cell cycle -dependent demethylation of CREB/ATF sites in the LTR.
AIDS (London, England) 2003;17(2):167-75.
2003: Shigeru Kyuwa; Seiji Kawamura; Yoh-ichi Tagawa; Yoichiro Iwakura; Toru Urano; Yasuhiro Yoshikawa
Differences between BALB/c and C57BL/6 mice in mouse hepatitis virus replication in primary hepatocyte culture.
Experimental animals / Japanese Association for Laboratory Animal Science 2003;52(1):81-4.
2003: Tomohiro Kurisaki; Aki Masuda; Katsuko Sudo; Junko Sakagami; Shigeki Higashiyama; Yoichi Matsuda; Akira Nagabukuro; Atsushi Tsuji; Yo-ichi Nabeshima; Masahide Asano; Yoichiro Iwakura; Atsuko Sehara-Fujisawa
Phenotypic analysis of Meltrin alpha (ADAM12)-deficient mice: involvement of Meltrin alpha in adipogenesis and myogenesis.
Molecular and cellular biology 2003;23(1):55-61.
2003: Yuji Ikegaya; Isabelle Delcroix; Yoichiro Iwakura; Norio Matsuki; Nobuyoshi Nishiyama
Interleukin-1beta abrogates long-term depression of hippocampal CA1 synaptic transmission.
Synapse (New York, N.Y.) 2003;47(1):54-7.
2002: Masaru Yoshida; Yasuhiko Shirai; Tomohiro Watanabe; Masashi Yamori; Yoichiro Iwakura; Tsutomu Chiba; Toru Kita; Yoshio Wakatsuki
Differential localization of colitogenic Th1 and Th2 cells monospecific to a microflora-associated antigen in mice.
Gastroenterology 2002;123(6):1949-61.
2002: Masashi Desaki; Isamu Sugawara; Yoichiro Iwakura; Kazuhiko Yamamoto; Hajime Takizawa
Role of interferon-gamma in the development of murine bronchus-associated lymphoid tissues induced by silica in vivo.
Toxicology and applied pharmacology 2002;185(1):1-7.
2002: Yoichiro Iwakura
[Mouse models for rheumatoid arthritis and their use in drug development].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2002;120(5):303-13.
2002: Kazuhiro Sakamaki; T Inoue; Masahide Asano; Katsuko Sudo; Hirotaka Kazama; Junko Sakagami; Shin-ichi Sakata; M Ozaki; S Nakamura; Shinya Toyokuni; N Osumi; Yoichiro Iwakura; Shin Yonehara
Ex vivo whole-embryo culture of caspase-8-deficient embryos normalize their aberrant phenotypes in the developing neural tube and heart.
Cell death and differentiation 2002;9(11):1196-206.
2002: Shigeru Kakuta; Shinwa Shibata; Yoichiro Iwakura
Genomic structure of the mouse 2',5'-oligoadenylate synthetase gene family.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2002;22(9):981-93.
2002: Susumu Nakae; Yutaka Komiyama; Aya Nambu; Katsuko Sudo; Michiko Iwase; Ikuo Homma; Kenji Sekikawa; Masahide Asano; Yoichiro Iwakura
Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses.
Immunity 2002;17(3):375-87.
2002: Yoichiro Iwakura
Roles of IL-1 in the development of rheumatoid arthritis: consideration from mouse models.
Cytokine & growth factor reviews 2002;13(4-5):341-55.
2002: Shoji Yamamoto; Shogo Oka; Mitsuhiro Inoue; Misa Shimuta; Toshiya Manabe; Hideki Takahashi; Masaomi Miyamoto; Masahide Asano; Junko Sakagami; Katsuko Sudo; Yoichiro Iwakura; Katsuhiko Ono; Toshisuke Kawasaki
Mice deficient in nervous system-specific carbohydrate epitope HNK-1 exhibit impaired synaptic plasticity and spatial learning.
The Journal of biological chemistry 2002;277(30):27227-31.
2002: Yoshinori Nagai; Sachiko Akashi; Masakazu Nagafuku; Masato Ogata; Yoichiro Iwakura; Shizuo Akira; Toshio Kitamura; Atsushi Kosugi; Masao Kimoto; Kensuke Miyake
Essential role of MD-2 in LPS responsiveness and TLR4 distribution.
Nature immunology 2002;3(7):667-72.
2002: Shigeru Kyuwa; Shinwa Shibata; Yoh-ichi Tagawa; Yoichiro Iwakura; Katsuyuki Machii; Toru Urano
Acute hepatic failure in IFN-gamma-deficient BALB/c mice after murine coronavirus infection.
Virus research 2002;83(1-2):169-77.
2002: Shinobu Saijo; Masahide Asano; Reiko Horai; Hiroaki Yamamoto; Yoichiro Iwakura
Suppression of autoimmune arthritis in interleukin-1-deficient mice in which T cell activation is impaired due to low levels of CD40 ligand and OX40 expression on T cells.
Arthritis and rheumatism 2002;46(2):533-44.
2002: Masashi Furuzawa; Masayoshi Kuwahara; Keiji Ishii; Yoichiro Iwakura; Hirokazu Tsubone
Diurnal variation of heart rate, locomotor activity, and body temperature in interleukin-1 alpha/beta doubly deficient mice.
Experimental animals / Japanese Association for Laboratory Animal Science 2002;51(1):49-56.
2002: Shigeru Kakuta; Yoh-ichi Tagawa; Shinwa Shibata; Masanobu Nanno; Yoichiro Iwakura
Inhibition of B16 melanoma experimental metastasis by interferon-gamma through direct inhibition of cell proliferation and activation of antitumour host mechanisms.
Immunology 2002;105(1):92-100.
2002: Hiroshi Yokoyama; Jiro Yasuda; Hiroaki Okamoto; Yoichiro Iwakura
Pathological changes of renal epithelial cells in mice transgenic for the TT virus ORF1 gene.
The Journal of general virology 2002;83(Pt 1):141-50.
2001: Susumu Nakae; Masahide Asano; Reiko Horai; Yoichiro Iwakura
Interleukin-1 beta, but not interleukin-1 alpha, is required for T-cell-dependent antibody production.
Immunology 2001;104(4):402-9.
2001: Susumu Nakae; C Naruse-Nakajima; Katsuko Sudo; Reiko Horai; Masahide Asano; Yoichiro Iwakura
IL-1 alpha, but not IL-1 beta, is required for contact-allergen-specific T cell activation during the sensitization phase in contact hypersensitivity.
International immunology 2001;13(12):1471-8.
2001: Norihiro Kotani; Masahide Asano; Yoichiro Iwakura; Seiichi Takasaki
Knockout of mouse beta 1,4-galactosyltransferase-1 gene results in a dramatic shift of outer chain moieties of N-glycans from type 2 to type 1 chains in hepatic membrane and plasma glycoproteins.
The Biochemical journal 2001;357(Pt 3):827-34.
2001: J Yasuda; T Miyao; M Kamata; Y Aida; Yoichiro Iwakura
T cell apoptosis causes peripheral T cell depletion in mice transgenic for the HIV-1 vpr gene.
Virology 2001;285(2):181-92.
2001: Susumu Nakae; Masahide Asano; Reiko Horai; Nobuo Sakaguchi; Yoichiro Iwakura
IL-1 enhances T cell-dependent antibody production through induction of CD40 ligand and OX40 on T cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(1):90-7.
2001: Shinwa Shibata; Shigeru Kakuta; K Hamada; Y Sokawa; Yoichiro Iwakura
Cloning of a novel 2',5'-oligoadenylate synthetase-like molecule, Oasl5 in mice.
Gene 2001;271(2):261-71.
2001: Toshihiko Yoneto; Seiji Waki; T Takai; Yoichiro Iwakura; Junichiro Mizuguchi; H Nariuchi; Takayuki Yoshimoto
A critical role of Fc receptor-mediated antibody-dependent phagocytosis in the host resistance to blood-stage Plasmodium berghei XAT infection.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(10):6236-41.
2001: C Naruse-Nakajima; Masahide Asano; Yoichiro Iwakura
Involvement of EphA2 in the formation of the tail notochord via interaction with ephrinA1.
Mechanisms of development 2001;102(1-2):95-105.
2001: Shigeru Kyuwa; S Kawamura; S Shibata; Katsuyuki Machii; Yoh-ichi Tagawa; Yoichiro Iwakura; Toru Urano
The severity of hepatic lesion after intraperitoneal JHMV infection in IFN-gamma deficient mice is parallel to viral replication in hepatocytes in vitro.
Advances in experimental medicine and biology 2001;494():95-9.
2000: Kazuyoshi Kawakami; Yoshinobu Koguchi; Mahboob Hossain Qureshi; Akiko Miyazato; Satomi Yara; Yuki Kinjo; Yoichiro Iwakura; Kiyoshi Takeda; Shizuo Akira; M Kurimoto; Atsushi Saito
IL-18 contributes to host resistance against infection with Cryptococcus neoformans in mice with defective IL-12 synthesis through induction of IFN-gamma production by NK cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(2):941-7.
2000: J Tanaka; H Ozaki; J Yasuda; Reiko Horai; Y Tagawa; Masahide Asano; Shinobu Saijo; M Imai; K Sekikawa; M Kopf; Yoichiro Iwakura
Lipopolysaccharide-induced HIV-1 expression in transgenic mice is mediated by tumor necrosis factor-alpha and interleukin-1, but not by interferon-gamma nor interleukin-6.
AIDS (London, England) 2000;14(10):1299-307.
2000: Ikuo Igarashi; U Asaba; Mohamed Mohamed Ahmed; Yoshitaka Omata; Atsushi Saito; Hideyuki Nagasawa; K Fujisaki; Naoyoshi Suzuki; Yoichiro Iwakura; Takeshi Mikami
Immunization with recombinant surface antigens p26 with Freund's adjuvants against Babesia rodhaini infection.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 2000;62(7):717-23.
2000: N Uetani; Kanefusa Kato; H Ogura; K Mizuno; K Kawano; Katsuhiko Mikoshiba; Hidetaka Yakura; Masahide Asano; Yoichiro Iwakura
Impaired learning with enhanced hippocampal long-term potentiation in PTPdelta-deficient mice.
The EMBO journal 2000;19(12):2775-85.
2000: Akiko Miyazato; Kazuyoshi Kawakami; Yoichiro Iwakura; Atsushi Saito
Chemokine synthesis and cellular inflammatory changes in lungs of mice bearing p40tax of human T-lymphotropic virus type 1.
Clinical and experimental immunology 2000;120(1):113-24.
2000: Reiko Horai; Shinobu Saijo; H Tanioka; Susumu Nakae; Katsuko Sudo; Akihiko Okahara; Toshimi Ikuse; Masahide Asano; Yoichiro Iwakura
Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice.
The Journal of experimental medicine 2000;191(2):313-20.
2000: Ayako Hino; Osamu Igarashi; Y I Tagawa; Yoichiro Iwakura; H Nariuchi
Interferon gamma priming is not critical for IL-12 production of murine spleen cells.
Cytokine 2000;12(1):12-20.
1999: Shinobu Saijo; Motoko Kotani; K Habu; C Ishitsuka; Hiroaki Yamamoto; Takashi Sekiguchi; Yoichiro Iwakura
Bone marrow-derived cells are responsible for the development of autoimmune arthritis in human T cell leukemia virus type I-transgenic mice and those of normal mice can suppress the disease.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(10):5700-7.
1999: Kazuyoshi Kawakami; Akiko Miyazato; Yoichiro Iwakura; Atsushi Saito
Induction of lymphocytic inflammatory changes in lung interstitium by human T lymphotropic virus type I.
American journal of respiratory and critical care medicine 1999;160(3):995-1000.
1999: Ikuo Igarashi; R Suzuki; Seiji Waki; Y Tagawa; S Seng; S Tum; Yoshitaka Omata; Atsushi Saito; Hideyuki Nagasawa; Yoichiro Iwakura; Naoyoshi Suzuki; Takeshi Mikami; yutaka toyoda
Roles of CD4(+) T cells and gamma interferon in protective immunity against Babesia microti infection in mice.
Infection and immunity 1999;67(8):4143-8.
1999: Norihiro Kotani; Masahide Asano; Yoichiro Iwakura; Seiichi Takasaki
Impaired galactosylation of core 2 O-glycans in erythrocytes of beta1,4-galactosyltransferase knockout mice.
Biochemical and biophysical research communications 1999;260(1):94-8.
1999: K Habu; J Nakayama-Yamada; Masahide Asano; Shinobu Saijo; K Itagaki; Reiko Horai; Hiroaki Yamamoto; Takashi Sekiguchi; Tetsuya Nosaka; M Hatanaka; Yoichiro Iwakura
The human T cell leukemia virus type I-tax gene is responsible for the development of both inflammatory polyarthropathy resembling rheumatoid arthritis and noninflammatory ankylotic arthropathy in transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(5):2956-63.
1999: Motoko Kotani; Y Tagawa; Yoichiro Iwakura
Involvement of autoimmunity against type II collagen in the development of arthritis in mice transgenic for the human T cell leukemia virus type I tax gene.
European journal of immunology 1999;29(1):54-64.
1998: Yoichiro Iwakura; K Itagaki; C Ishitsuka; Y Yamasaki; A Matsuzawa; Shin Yonehara; S Karasawa; S Ueda; Shinobu Saijo
The development of autoimmune inflammatory arthropathy in mice transgenic for the human T cell leukemia virus type-1 env-pX region is not dependent on H-2 haplotypes and modified by the expression levels of Fas antigen.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(12):6592-8.
1998: Y Tagawa; S Kakuta; Yoichiro Iwakura
Involvement of Fas/Fas ligand system-mediated apoptosis in the development of concanavalin A-induced hepatitis.
European journal of immunology 1998;28(12):4105-13.
1998: Shigeru Kyuwa; Yoh-ichi Tagawa; Shinwa Shibata; Kunio Doi; Katsuyuki Machii; Yoichiro Iwakura
Murine coronavirus-induced subacute fatal peritonitis in C57BL/6 mice deficient in gamma interferon.
Journal of virology 1998;72(11):9286-90.
1998: Reiko Horai; Masahide Asano; Katsuko Sudo; Hirotaka Kanuka; Masato Suzuki; Masugi Nishihara; M Takahashi; Yoichiro Iwakura
Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion.
The Journal of experimental medicine 1998;187(9):1463-75.
1998: Shigeru Kyuwa; Yoh-ichi Tagawa; Katsuyuki Machii; Shinwa Shibata; Kunio Doi; K Fujiwara; Yoichiro Iwakura
MHV-induced fatal peritonitis in mice lacking IFN-gamma.
Advances in experimental medicine and biology 1998;440():445-50.
1997: Y Tagawa; K Sekikawa; Yoichiro Iwakura
Suppression of concanavalin A-induced hepatitis in IFN-gamma(-/-) mice, but not in TNF-alpha(-/-) mice: role for IFN-gamma in activating apoptosis of hepatocytes.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(3):1418-28.
1997: S Kishi; S Saijyo; M Arai; S Karasawa; S Ueda; M Kannagi; Yoichiro Iwakura; M Fujii; S Yonehara
Resistance to fas-mediated apoptosis of peripheral T cells in human T lymphocyte virus type I (HTLV-I) transgenic mice with autoimmune arthropathy.
The Journal of experimental medicine 1997;186(1):57-64.
1997: Masahide Asano; K Furukawa; M Kido; S Matsumoto; Y Umesaki; N Kochibe; Yoichiro Iwakura
Growth retardation and early death of beta-1,4-galactosyltransferase knockout mice with augmented proliferation and abnormal differentiation of epithelial cells.
The EMBO journal 1997;16(8):1850-7.
1995: Yoichiro Iwakura
[Chronic rheumatoid arthritis model mice transgenic for the HTLV-I tax gene].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1995;40(14):2074-82.
1995: Yoichiro Iwakura; Shinobu Saijo; Y Kioka; J Nakayama-Yamada; K Itagaki; M Tosu; Masahide Asano; Y Kanai; K Kakimoto
Autoimmunity induction by human T cell leukemia virus type 1 in transgenic mice that develop chronic inflammatory arthropathy resembling rheumatoid arthritis in humans.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(3):1588-98.
1995: Yoichiro Iwakura; M Tosu; E Yoshida; Shinobu Saijo; J Nakayama-Yamada; K Itagaki; Masahide Asano; H Siomi; M Hatanaka; T Takeda
Augmentation of c-fos and c-jun expression in transgenic mice carrying the human T-cell leukemia virus type-I tax gene.
Virus genes 1995;9(2):161-70.
1993: Hiroaki Yamamoto; Takashi Sekiguchi; K Itagaki; Shinobu Saijo; Yoichiro Iwakura
Inflammatory polyarthritis in mice transgenic for human T cell leukemia virus type I.
Arthritis and rheumatism 1993;36(11):1612-20.
1993: T Endo; Yoichiro Iwakura; Akira Kobata
Structural changes in the N-linked sugar chains of serum immunoglobulin G of HTLV-I transgenic mice.
Biochemical and biophysical research communications 1993;192(3):1004-10.
1993: T Hayashi; Yoichiro Iwakura
[Detection of RNA packaging signal of HIV-1 and its application for a novel AIDS therapy].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1993;38(4):779-83.
1992: Yoichiro Iwakura; Tatsuo Shioda; M Tosu; E Yoshida; M Hayashi; T Nagata; H Shibuta
The induction of cataracts by HIV-1 in transgenic mice.
AIDS (London, England) 1992;6(10):1069-75.
1992: T Hayashi; Tatsuo Shioda; Yoichiro Iwakura; H Shibuta
RNA packaging signal of human immunodeficiency virus type 1.
Virology 1992;188(2):590-9.
1991: Yoichiro Iwakura; M Tosu; E Yoshida; M Takiguchi; K Sato; I Kitajima; Kiyoshi Nishioka; K Yamamoto; T Takeda; M Hatanaka
Induction of inflammatory arthropathy resembling rheumatoid arthritis in mice transgenic for HTLV-I.
Science (New York, N.Y.) 1991;253(5023):1026-8.
1990: M Asano; M Hayashi; E Yoshida; Y Kawade; Yoichiro Iwakura
Induction of interferon-alpha by interferon-beta, but not of interferon-beta by interferon-alpha, in the mouse.
Virology 1990;176(1):30-8.
1988: Yoichiro Iwakura; M Asano; Y Nishimune; Y Kawade
Male sterility of transgenic mice carrying exogenous mouse interferon-beta gene under the control of the metallothionein enhancer-promoter.
The EMBO journal 1988;7(12):3757-62.
1988: M Asano; H Nagashima; Yoichiro Iwakura; Y Kawade
Interferon production under the control of heterologous inducible enhancers and promoters.
Microbiology and immunology 1988;32(6):589-96.