FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Alfred Ayala

Research Profile

Living Beings

Disorders

Anatomy

Chemicals & Drugs

Procedures

Resuscitation

Physiology

Cellular Immunity

Co-author Network

Publications

TOP 3
Nicholas J Shubin; Chun S Chung; Daithi S Heffernan; Lydea R Irwin; Sean F Monaghan; Alfred Ayala
BTLA expression contributes to septic morbidity and mortality by inducing innate inflammatory cell dysfunction.
Sean F Monaghan; Rajan K Thakkar; Mai L Tran; Alfred Ayala; William G Cioffi; Xin Huang; Daithi S Heffernan
Programmed death 1 expression as a marker for immune and physiological dysfunction in the critically ill surgical patient.
Daithi S Heffernan; Jason T Machan; Sean F Monaghan; Rajan K Thakkar; William G Cioffi; Alfred Ayala
Failure to normalize lymphopenia following trauma is associated with increased mortality, independent of the leukocytosis pattern.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Alfred Ayala (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2012: Nicholas J Shubin; Chun S Chung; Daithi S Heffernan; Lydea R Irwin; Sean F Monaghan; Alfred Ayala
BTLA expression contributes to septic morbidity and mortality by inducing innate inflammatory cell dysfunction.
Journal of leukocyte biology 2012;92(3):593-603.
2012: Sean F Monaghan; Rajan K Thakkar; Mai L Tran; Alfred Ayala; William G Cioffi; Xin Huang; Daithi S Heffernan
Programmed death 1 expression as a marker for immune and physiological dysfunction in the critically ill surgical patient.
Shock (Augusta, Ga.) 2012;38(2):117-22.
2012: Daithi S Heffernan; Jason T Machan; Sean F Monaghan; Rajan K Thakkar; William G Cioffi; Alfred Ayala
Failure to normalize lymphopenia following trauma is associated with increased mortality, independent of the leukocytosis pattern.
Critical care (London, England) 2012;16(1):R12.
2011: Courtni T Newsome; Alfred Ayala; Estefany Flores; Stephen Gregory; Jonathan S Reichner
Improved antimicrobial host defense in mice following poly-(1,6)-β-D-glucopyranosyl-(1,3)-β-D-glucopyranose glucan treatment by a gender-dependent immune mechanism.
Clinical and vaccine immunology : CVI 2011;18(12):2043-9.
2011: Ying-Jie Guan; Weiling Hu; Minsoo Kim; Li Ma; Lijuan Wang; Li Xu; Zhong-Fa Yang; Chen Yu; Zhe Zhang; Shusen Zheng; Shougang Zhuang; Alicia S Chung; Chun-Shiang Chung; Loren D Fast; Jin-Song Gao; Alfred Ayala; Y Eugene Chin
Phospho-SXXE/D motif mediated TNF receptor 1-TRADD death domain complex formation for T cell activation and migration.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(3):1289-97.
2011: Nicholas J Shubin; Sean F Monaghan; Alfred Ayala
Anti-inflammatory mechanisms of sepsis.
Contributions to microbiology 2011;17():108-24.
2010: Chun-Shiang Chung; Fabienne Venet; Yaping Chen; Leslie N Jones; Douglas C Wilson; Carol A Ayala; Alfred Ayala
Deficiency of Bid protein reduces sepsis-induced apoptosis and inflammation, while improving septic survival.
Shock (Augusta, Ga.) 2010;34(2):150-61.
2010: Mario Perl; Chun-Shiang Chung; Ulrike Perl; Rajan Thakkar; Joanne Lomas-Neira; Alfred Ayala
Therapeutic accessibility of caspase-mediated cell death as a key pathomechanism in indirect acute lung injury.
Critical care medicine 2010;38(4):1179-86.
2010: Fabienne Venet; Xin Huang; Chun-Shiang Chung; Yaping Chen; Alfred Ayala
Plasmacytoid dendritic cells control lung inflammation and monocyte recruitment in indirect acute lung injury in mice.
The American journal of pathology 2010;176(2):764-73.
2009: Fabienne Venet; Chun-Shiang Chung; Xin Huang; Joanne Lomas-Neira; Yaping Chen; Alfred Ayala
Lymphocytes in the development of lung inflammation: a role for regulatory CD4+ T cells in indirect pulmonary lung injury.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(5):3472-80.
2009: Gwendolyn F Elphick; Pranita P Sarangi; Young-Min Hyun; Joseph A Hollenbaugh; Alfred Ayala; Walter L Biffl; Hung-Li Chung; Alireza R Rezaie; James L McGrath; David J Topham; Jonathan S Reichner; Minsoo Kim
Recombinant human activated protein C inhibits integrin-mediated neutrophil migration.
Blood 2009;113(17):4078-85.
2009: Xin Huang; Fabienne Venet; Yvonne L Wang; Alain Lepape; Zhenglong Yuan; Yaping Chen; Ryan Swan; Hakim Kherouf; Guillaume Monneret; Chun-Shiang Chung; Alfred Ayala
PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(15):6303-8.
2009: Fabienne Venet; Chun-Shiang Chung; Hakim Kherouf; Anne Geeraert; Chistophe Malcus; Françoise Poitevin; Julien Bohé; Alain Lepape; Alfred Ayala; Guillaume Monneret
Increased circulating regulatory T cells (CD4(+)CD25 (+)CD127 (-)) contribute to lymphocyte anergy in septic shock patients.
Intensive care medicine 2009;35(4):678-86.
2009: Caroline K Hu; Fabienne Venet; David S Heffernan; Yvonne L Wang; Brian Horner; Xin Huang; Chun-Shiang Chung; Stephen H Gregory; Alfred Ayala
The role of hepatic invariant NKT cells in systemic/local inflammation and mortality during polymicrobial septic shock.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(4):2467-75.
2008: Nicholas S Ward; Brian Casserly; Alfred Ayala
The compensatory anti-inflammatory response syndrome (CARS) in critically ill patients.
Clinics in chest medicine 2008;29(4):617-25, viii.
2008: Mario Perl; Joanne Lomas-Neira; Chun-Shiang Chung; Alfred Ayala
Epithelial cell apoptosis and neutrophil recruitment in acute lung injury-a unifying hypothesis? What we have learned from small interfering RNAs.
Molecular medicine (Cambridge, Mass.) 2008;14(7-8):465-75.
2008: Fabienne Venet; Chun-Shiang Chung; Guillaume Monneret; Xin Huang; Brian Horner; Megan Garber; Alfred Ayala
Regulatory T cell populations in sepsis and trauma.
Journal of leukocyte biology 2008;83(3):523-35.
2008: Alfred Ayala; Mario Perl; Fabienne Venet; Joanne Lomas-Neira; Ryan Swan; Chun-Shiang Chung
Apoptosis in sepsis: mechanisms, clinical impact and potential therapeutic targets.
Current pharmaceutical design 2008;14(19):1853-9.
2008: Doreen E Wesche-Soldato; Joanne Lomas-Neira; Mario Perl; Chun-Shiang Chung; Alfred Ayala
Hydrodynamic delivery of siRNA in a mouse model of sepsis.
Methods in molecular biology (Clifton, N.J.) 2008;442():67-73.
2007: Joanne Lomas-Neira; Alfred Ayala
CXCL2 polymorphism in sepsis and acute respiratory distress syndrome: pathological significance lost in translation.
Critical care medicine 2007;35(10):2439-40.
2007: Mario Perl; Chun-Shiang Chung; Ulrike Perl; Joanne Lomas-Neira; Monique de Paepe; William G Cioffi; Alfred Ayala
Fas-induced pulmonary apoptosis and inflammation during indirect acute lung injury.
American journal of respiratory and critical care medicine 2007;176(6):591-601.
2007: Ryan Swan; Chun-Shiang Chung; Jorge E Albina; William G Cioffi; Mario Perl; Alfred Ayala
Polymicrobial sepsis enhances clearance of apoptotic immune cells by splenic macrophages.
Surgery 2007;142(2):253-61.
2007: Xin Huang; Fabienne Venet; Chun-Shiang Chung; Joanne Lomas-Neira; Alfred Ayala
Changes in dendritic cell function in the immune response to sepsis. Cell- & tissue-based therapy.
Expert opinion on biological therapy 2007;7(7):929-38.
2007: Doreen E Wesche-Soldato; Chun-Shiang Chung; Stephen H Gregory; Thais P Salazar-Mather; Carol A Ayala; Alfred Ayala
CD8+ T cells promote inflammation and apoptosis in the liver after sepsis: role of Fas-FasL.
The American journal of pathology 2007;171(1):87-96.
2007: Chun-Shiang Chung; Yaping Chen; Patricia S Grutkoski; Lesley A Doughty; Alfred Ayala
SOCS-1 is a central mediator of steroid-increased thymocyte apoptosis and decreased survival following sepsis.
Apoptosis : an international journal on programmed cell death 2007;12(7):1143-53.
2007: Mario Perl; Chun-Shiang Chung; Ulrike Perl; Walter L Biffl; William G Cioffi; Alfred Ayala
Beneficial versus detrimental effects of neutrophils are determined by the nature of the insult.
Journal of the American College of Surgeons 2007;204(5):840-52; discussion 852-3.
2007: Doreen E Wesche-Soldato; Ryan Swan; Chun-Shiang Chung; Alfred Ayala
The apoptotic pathway as a therapeutic target in sepsis.
Current drug targets 2007;8(4):493-500.
2007: Nicholas Wisnoski; Chun-Shiang Chung; Yaping Chen; Xin Huang; Alfred Ayala
The contribution of CD4+ CD25+ T-regulatory-cells to immune suppression in sepsis.
Shock (Augusta, Ga.) 2007;27(3):251-7.
2007: Alfred Ayala; Doreen E Wesche-Soldato; Mario Perl; Joanne Lomas-Neira; Ryan Swan; Chun-Shiang Chung
Blockade of apoptosis as a rational therapeutic strategy for the treatment of sepsis.
Novartis Foundation symposium 2007;280():37-49; discussion 49-52, 160-4.
2006: Chun-Shiang Chung; Lara Watkins; Antonio Funches; Joanne Lomas-Neira; William G Cioffi; Alfred Ayala
Deficiency of gammadelta T lymphocytes contributes to mortality and immunosuppression in sepsis.
American journal of physiology. Regulatory, integrative and comparative physiology 2006;291(5):R1338-43.
2006: Lesley A Doughty; Stacey Carlton; Benjamin Galen; Indranie Cooma-Ramberan; Chun-Shiang Chung; Alfred Ayala
Activation of common antiviral pathways can potentiate inflammatory responses to septic shock.
Shock (Augusta, Ga.) 2006;26(2):187-94.
2006: Alfred Ayala; Doreen E Wesche-Soldato; Megan Garber; Ryan Swan; Mario Perl
No good deed goes unpunished!
Intensive care medicine 2006;32(5):637-8.
2006: Joanne Lomas-Neira; Chun-Shiang Chung; Mario Perl; Stephen Gregory; Walter L Biffl; Alfred Ayala
Role of alveolar macrophage and migrating neutrophils in hemorrhage-induced priming for ALI subsequent to septic challenge.
American journal of physiology. Lung cellular and molecular physiology 2006;290(1):L51-8.
2006: Mario Perl; Chun-Shiang Chung; Megan Garber; Xin Huang; Alfred Ayala
Contribution of anti-inflammatory/immune suppressive processes to the pathology of sepsis.
Frontiers in bioscience : a journal and virtual library 2006;11():272-99.
2005: Mario Perl; Chun-Shiang Chung; Alfred Ayala
Apoptosis.
Critical care medicine 2005;33(12 Suppl):S526-9.
2005: Mario Perl; Chun-Shiang Chung; Joanne Lomas-Neira; Tina-Marie Rachel; Walter L Biffl; William G Cioffi; Alfred Ayala
Silencing of Fas, but not caspase-8, in lung epithelial cells ameliorates pulmonary apoptosis, inflammation, and neutrophil influx after hemorrhagic shock and sepsis.
The American journal of pathology 2005;167(6):1545-59.
2005: Joanne Lomas-Neira; Alfred Ayala
Pepducins: an effective means to inhibit GPCR signaling by neutrophils.
Trends in immunology 2005;26(12):619-21.
2005: Grace Y Song; Chun-Shiang Chung; Rebecca J Rhee; William G Cioffi; Alfred Ayala
Loss of signal transducer and activator of transduction 4 or 6 signaling contributes to immune cell morbidity and mortality in sepsis.
Intensive care medicine 2005;31(11):1564-9.
2005: Doreen E Wesche-Soldato; Chun-Shiang Chung; Joanne Lomas-Neira; Lesley A Doughty; Stephen H Gregory; Alfred Ayala
In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice.
Blood 2005;106(7):2295-301.
2005: Joanne Lomas-Neira; Chun-Shiang Chung; Patricia S Grutkoski; AnnMarie Dunican; H Hank Simms; William G Cioffi; Alfred Ayala
Divergent roles of murine neutrophil chemokines in hemorrhage induced priming for acute lung injury.
Cytokine 2005;31(3):169-79.
2005: Doreen E Wesche; Joanne Lomas-Neira; Mario Perl; Chun-Shiang Chung; Alfred Ayala
Leukocyte apoptosis and its significance in sepsis and shock.
Journal of leukocyte biology 2005;78(2):325-37.
2005: Joanne Lomas-Neira; Chun-Shiang Chung; Doreen E Wesche; Mario Perl; Alfred Ayala
In vivo gene silencing (with siRNA) of pulmonary expression of MIP-2 versus KC results in divergent effects on hemorrhage-induced, neutrophil-mediated septic acute lung injury.
Journal of leukocyte biology 2005;77(6):846-53.
2005: Doreen E Wesche-Soldato; Joanne Lomas-Neira; Mario Perl; Leslie Jones; Chun-Shiang Chung; Alfred Ayala
The role and regulation of apoptosis in sepsis.
Journal of endotoxin research 2005;11(6):375-82.
2004: Yanli Ding; Chun-Shiang Chung; Sarah Newton; Yaping Chen; Stacey Carlton; Jorge E Albina; Alfred Ayala
Polymicrobial sepsis induces divergent effects on splenic and peritoneal dendritic cell function in mice.
Shock (Augusta, Ga.) 2004;22(2):137-44.
2004: Joanne Lomas-Neira; Chun-Shiang Chung; Patricia S Grutkoski; Edmund Miller; Alfred Ayala
CXCR2 inhibition suppresses hemorrhage-induced priming for acute lung injury in mice.
Journal of leukocyte biology 2004;76(1):58-64.
2004: Patricia S Grutkoski; Yaping Chen; Chun-Shiang Chung; William G Cioffi; Alfred Ayala
Putative mechanism of hemorrhage-induced leukocyte hyporesponsiveness: induction of suppressor of cytokine signaling-3.
The Journal of trauma 2004;56(4):742-7; discussion 747-8.
2004: Sarah Newton; Yanli Ding; Chun-Shiang Chung; Yaping Chen; Joanne Lomas-Neira; Alfred Ayala
Sepsis-induced changes in macrophage co-stimulatory molecule expression: CD86 as a regulator of anti-inflammatory IL-10 response.
Surgical infections 2004;5(4):375-83.
2003: Rebecca J Rhee; Stacey Carlton; Joanne L Lomas; Crystal Lane; Laurent Brossay; William G Cioffi; Alfred Ayala
Inhibition of CD1d activation suppresses septic mortality: a role for NK-T cells in septic immune dysfunction.
The Journal of surgical research 2003;115(1):74-81.
2003: Patricia S Grutkoski; Y Chen; Chun-Shiang Chung; Alfred Ayala
Sepsis-induced SOCS-3 expression is immunologically restricted to phagocytes.
Journal of leukocyte biology 2003;74(5):916-22.
2003: Chun-Shiang Chung; Grace Y Song; Joanne Lomas; H Hank Simms; Irshad H Chaudry; Alfred Ayala
Inhibition of Fas/Fas ligand signaling improves septic survival: differential effects on macrophage apoptotic and functional capacity.
Journal of leukocyte biology 2003;74(3):344-51.
2003: Alfred Ayala; Chun-Shiang Chung; Patricia S Grutkoski; Grace Y Song
Mechanisms of immune resolution.
Critical care medicine 2003;31(8 Suppl):S558-71.
2003: Patricia S Grutkoski; C Thomas Graeber; Yow-Pin Lim; Alfred Ayala; H Hank Simms
Alpha-defensin 1 (human neutrophil protein 1) as an antichemotactic agent for human polymorphonuclear leukocytes.
Antimicrobial agents and chemotherapy 2003;47(8):2666-8.
2003: Martin K Angele; Stefan M Nitsch; Markus W Knoferl; Alfred Ayala; Peter Angele; Friedrich W Schildberg; Karl-Walter Jauch; Irshad H Chaudry
Sex-specific p38 MAP kinase activation following trauma-hemorrhage: involvement of testosterone and estradiol.
American journal of physiology. Endocrinology and metabolism 2003;285(1):E189-96.
2003: Joanne L Lomas; Chun-Shiang Chung; Patricia S Grutkoski; Brian W LeBlanc; Liz Lavigne; Jonathan S Reichner; Stephen H Gregory; Lesley A Doughty; William G Cioffi; Alfred Ayala
Differential effects of macrophage inflammatory chemokine-2 and keratinocyte-derived chemokine on hemorrhage-induced neutrophil priming for lung inflammation: assessment by adoptive cells transfer in mice.
Shock (Augusta, Ga.) 2003;19(4):358-65.
2003: Alfred Ayala; Joanne L Lomas; Patricia S Grutkoski; Shiang Chung
Fas-ligand mediated apoptosis in severe sepsis and shock.
Scandinavian journal of infectious diseases 2003;35(9):593-600.
2003: Alfred Ayala; Joanne L Lomas; Patricia S Grutkoski; Chun-Shiang Chung
Pathological aspects of apoptosis in severe sepsis and shock?
The international journal of biochemistry & cell biology 2003;35(1):7-15.
2002: Alfred Ayala; Chun-Shiang Chung; Joanne L Lomas; Grace Y Song; Lesley A Doughty; Stephen H Gregory; William G Cioffi; Brian W LeBlanc; Jonathan S Reichner; H Hank Simms; Patricia S Grutkoski
Shock-induced neutrophil mediated priming for acute lung injury in mice: divergent effects of TLR-4 and TLR-4/FasL deficiency.
The American journal of pathology 2002;161(6):2283-94.
2002: Grace Y Song; Chun-Shiang Chung; Doraid Jarrar; William G Cioffi; Alfred Ayala
Mechanism of immune dysfunction in sepsis: inducible nitric oxide-meditated alterations in p38 MAPK activation.
The Journal of trauma 2002;53(2):276-82; discussion 282-3.
2002: Patricia S Grutkoski; Ron D'Amico; Alfred Ayala; H Hank Simms
Tumor necrosis factor-alpha-stimulated polymorphonuclear leukocytes suppress migration and bactericidal activity of polymorphonuclear leukocytes in a paracrine manner.
Critical care medicine 2002;30(3):591-7.
2002: Martin G Schwacha; Chun-Shiang Chung; Alfred Ayala; Kirby I Bland; Irshad H Chaudry
Cyclooxygenase 2-mediated suppression of macrophage interleukin-12 production after thermal injury.
American journal of physiology. Cell physiology 2002;282(2):C263-70.
2002: Shaolong Yang; Chun-Shiang Chung; Alfred Ayala; Irshad H Chaudry; Ping Wang
Differential alterations in cardiovascular responses during the progression of polymicrobial sepsis in the mouse.
Shock (Augusta, Ga.) 2002;17(1):55-60.
2002: Patricia S Grutkoski; C Thomas Graeber; Alfred Ayala; H Hank Simms
Paracrine suppression of apoptosis by cytokine-stimulated neutrophils involves divergent regulation of NF-kappaB, Bcl-X(L), and Bak.
Shock (Augusta, Ga.) 2002;17(1):47-54.
2002: Markus W Knöferl; Martin K Angele; Michael D Diodato; Martin G Schwacha; Alfred Ayala; William G Cioffi; Kirby I Bland; Irshad H Chaudry
Female sex hormones regulate macrophage function after trauma-hemorrhage and prevent increased death rate from subsequent sepsis.
Annals of surgery 2002;235(1):105-12.
2001: Martin K Angele; Markus W Knöferl; Alfred Ayala; Kirby I Bland; Irshad H Chaudry
Testosterone and estrogen differently effect Th1 and Th2 cytokine release following trauma-haemorrhage.
Cytokine 2001;16(1):22-30.
2001: Markus W Knöferl; Doraid Jarrar; Martin K Angele; Alfred Ayala; Martin G Schwacha; Kirby I Bland; Irshad H Chaudry
17 beta-Estradiol normalizes immune responses in ovariectomized females after trauma-hemorrhage.
American journal of physiology. Cell physiology 2001;281(4):C1131-8.
2001: Chun-Shiang Chung; W Wang; Irshad H Chaudry; Alfred Ayala
Increased apoptosis in lamina propria B cells during polymicrobial sepsis is FasL but not endotoxin mediated.
American journal of physiology. Gastrointestinal and liver physiology 2001;280(5):G812-8.
2001: Alfred Ayala; Chun-Shiang Chung; G Y Song; Irshad H Chaudry
IL-10 mediation of activation-induced TH1 cell apoptosis and lymphoid dysfunction in polymicrobial sepsis.
Cytokine 2001;14(1):37-48.
2001: Grace Y Song; Chun-Shiang Chung; Doraid Jarrar; Irshad H Chaudry; Alfred Ayala
Evolution of an immune suppressive macrophage phenotype as a product of P38 MAPK activation in polymicrobial sepsis.
Shock (Augusta, Ga.) 2001;15(1):42-8.
2000: AnnMarie Dunican; Stephanie J. Leuenroth; Patricia S Grutkoski; Alfred Ayala; H Hank Simms
TNFalpha-induced suppression of PMN apoptosis is mediated through interleukin-8 production.
Shock (Augusta, Ga.) 2000;14(3):284-8; discussion 288-9.
2000: Martin K Angele; F Fitzal; N Smail; Markus W Knöferl; Martin G Schwacha; Alfred Ayala; Ping Wang; Irshad H Chaudry
L-arginine attenuates trauma-hemorrhage-induced liver injury.
Critical care medicine 2000;28(9):3242-8.
2000: Alfred Ayala; Grace Y Song; Chun-Shiang Chung; K M Redmond; Irshad H Chaudry
Immune depression in polymicrobial sepsis: the role of necrotic (injured) tissue and endotoxin.
Critical care medicine 2000;28(8):2949-55.
2000: Martin K Angele; Martin G Schwacha; Alfred Ayala; Irshad H Chaudry
Effect of gender and sex hormones on immune responses following shock.
Shock (Augusta, Ga.) 2000;14(2):81-90.
2000: Stephanie J. Leuenroth; Patricia S Grutkoski; Alfred Ayala; H Hank Simms
Suppression of PMN apoptosis by hypoxia is dependent on Mcl-1 and MAPK activity.
Surgery 2000;128(2):171-7.
2000: G Y Song; Chun-Shiang Chung; Irshad H Chaudry; Alfred Ayala
IL-4-induced activation of the Stat6 pathway contributes to the suppression of cell-mediated immunity and death in sepsis.
Surgery 2000;128(2):133-8.
2000: Stephanie J. Leuenroth; Patricia S Grutkoski; Alfred Ayala; H Hank Simms
The loss of Mcl-1 expression in human polymorphonuclear leukocytes promotes apoptosis.
Journal of leukocyte biology 2000;68(1):158-66.
2000: Chun-Shiang Chung; Grace Y Song; L L Moldawer; Irshad H Chaudry; Alfred Ayala
Neither Fas ligand nor endotoxin is responsible for inducible peritoneal phagocyte apoptosis during sepsis/peritonitis.
The Journal of surgical research 2000;91(2):147-53.
2000: Grace Y Song; Chun-Shiang Chung; Irshad H Chaudry; Alfred Ayala
Immune suppression in polymicrobial sepsis: differential regulation of Th1 and Th2 responses by p38 MAPK.
The Journal of surgical research 2000;91(2):141-6.
2000: Chun-Shiang Chung; Grace Y Song; W Wang; Irshad H Chaudry; Alfred Ayala
Septic mucosal intraepithelial lymphoid immune suppression: role for nitric oxide not interleukin-10 or transforming growth factor-beta.
The Journal of trauma 2000;48(5):807-12; discussion 812-3.
2000: Martin G Schwacha; Alfred Ayala; Irshad H Chaudry
Insights into the role of gammadelta T lymphocytes in the immunopathogenic response to thermal injury.
Journal of leukocyte biology 2000;67(5):644-50.
2000: AnnMarie Dunican; Patricia S Grutkoski; Stephanie J. Leuenroth; Alfred Ayala; H Hank Simms
Neutrophils regulate their own apoptosis via preservation of CXC receptors.
The Journal of surgical research 2000;90(1):32-8.
2000: Markus W Knöferl; Michael D Diodato; Martin K Angele; Alfred Ayala; William G Cioffi; Kirby I Bland; Irshad H Chaudry
Do female sex steroids adversely or beneficially affect the depressed immune responses in males after trauma-hemorrhage?
Archives of surgery (Chicago, Ill. : 1960) 2000;135(4):425-33.
2000: AnnMarie Dunican; Stephanie J. Leuenroth; Alfred Ayala; H Hank Simms
CXC chemokine suppression of polymorphonuclear leukocytes apoptosis and preservation of function is oxidative stress independent.
Shock (Augusta, Ga.) 2000;13(3):244-50.
2000: V Kahlke; Martin K Angele; Martin G Schwacha; Alfred Ayala; William G Cioffi; Kirby I Bland; Irshad H Chaudry
Reversal of sexual dimorphism in splenic T lymphocyte responses after trauma-hemorrhage with aging.
American journal of physiology. Cell physiology 2000;278(3):C509-16.
2000: MW Wichmann; R Zellweger; Alfred Ayala; Irshad H Chaudry
Effect of naloxone on immune responses after hemorrhagic shock.
Critical care medicine 2000;28(1):184-9.
2000: V Kahlke; Martin K Angele; Alfred Ayala; Martin G Schwacha; William G Cioffi; Kirby I Bland; Irshad H Chaudry
Immune dysfunction following trauma-haemorrhage: influence of gender and age.
Cytokine 2000;12(1):69-77.
1999: Patricia S Grutkoski; Ron D'Amico; Alfred Ayala; H Hank Simms
IL-1beta stimulation induces paracrine regulation of PMN function and apoptosis.
Shock (Augusta, Ga.) 1999;12(5):373-81.
1999: Martin K Angele; Y X Xu; Alfred Ayala; Martin G Schwacha; R K Catania; William G Cioffi; Kirby I Bland; Irshad H Chaudry
Gender dimorphism in trauma-hemorrhage-induced thymocyte apoptosis.
Shock (Augusta, Ga.) 1999;12(4):316-22.
1999: Martin G Schwacha; Alfred Ayala; William G Cioffi; Kirby I Bland; Irshad H Chaudry
Role of protein kinase C in cyclic AMP-mediated suppression of T-lymphocyte activation following burn injury.
Biochimica et biophysica acta 1999;1455(1):45-53.
1999: G Y Song; Chun-Shiang Chung; Irshad H Chaudry; Alfred Ayala
What is the role of interleukin 10 in polymicrobial sepsis: anti-inflammatory agent or immunosuppressant?
Surgery 1999;126(2):378-83.
1999: Martin K Angele; Markus W Knöferl; Alfred Ayala; Jorge E Albina; William G Cioffi; Kirby I Bland; Irshad H Chaudry
Trauma-hemorrhage delays wound healing potentially by increasing pro-inflammatory cytokines at the wound site.
Surgery 1999;126(2):279-85.
1999: Martin K Angele; Markus W Knöferl; Martin G Schwacha; Alfred Ayala; William G Cioffi; Kirby I Bland; Irshad H Chaudry
Sex steroids regulate pro- and anti-inflammatory cytokine release by macrophages after trauma-hemorrhage.
The American journal of physiology 1999;277(1 Pt 1):C35-42.
1999: Robert A Catania; Martin K Angele; Alfred Ayala; William G Cioffi; Kirby I Bland; Irshad H Chaudry
Dehydroepiandrosterone restores immune function following trauma-haemorrhage by a direct effect on T lymphocytes.
Cytokine 1999;11(6):443-50.
1999: Alfred Ayala; Chun-Shiang Chung; Y X Xu; TA Evans; K M Redmond; Irshad H Chaudry
Increased inducible apoptosis in CD4+ T lymphocytes during polymicrobial sepsis is mediated by Fas ligand and not endotoxin.
Immunology 1999;97(1):45-55.
1999: Martin K Angele; Markus W Knöferl; Martin G Schwacha; Alfred Ayala; Kirby I Bland; William G Cioffi; S L Josephson; Irshad H Chaudry
Hemorrhage decreases macrophage inflammatory protein 2 and interleukin-6 release: a possible mechanism for increased wound infection.
Annals of surgery 1999;229(5):651-60; discussion 660-1.
1999: Grace Y Song; Chun-Shiang Chung; Martin G Schwacha; Doraid Jarrar; Irshad H Chaudry; Alfred Ayala
Splenic immune suppression in sepsis: A role for IL-10-induced changes in P38 MAPK signaling.
The Journal of surgical research 1999;83(1):36-43.
1999: Alfred Ayala; Y X Xu; Chun-Shiang Chung; Irshad H Chaudry
Does Fas ligand or endotoxin contribute to thymic apoptosis during polymicrobial sepsis?
Shock (Augusta, Ga.) 1999;11(3):211-7.
1999: Martin K Angele; Martin G Schwacha; N Smail; Robert A Catania; Alfred Ayala; William G Cioffi; Irshad H Chaudry
Hypoxemia in the absence of blood loss upregulates iNOS expression and activity in macrophages.
The American journal of physiology 1999;276(2 Pt 1):C285-90.
1999: Martin K Angele; N Smail; Alfred Ayala; William G Cioffi; Kirby I Bland; Irshad H Chaudry
L-arginine: a unique amino acid for restoring the depressed macrophage functions after trauma-hemorrhage.
The Journal of trauma 1999;46(1):34-41.
1999: Markus W Knöferl; Martin K Angele; Alfred Ayala; William G Cioffi; Kirby I Bland; Irshad H Chaudry
Do different rates of fluid resuscitation adversely or beneficially influence immune responses after trauma-hemorrhage?
The Journal of trauma 1999;46(1):23-33.
1999: Martin K Angele; N Smail; Markus W Knöferl; Alfred Ayala; William G Cioffi; Irshad H Chaudry
L-Arginine restores splenocyte functions after trauma and hemorrhage potentially by improving splenic blood flow.
The American journal of physiology 1999;276(1 Pt 1):C145-51.
1998: Martin K Angele; Robert A Catania; Alfred Ayala; William G Cioffi; Kirby I Bland; Irshad H Chaudry
Dehydroepiandrosterone: an inexpensive steroid hormone that decreases the mortality due to sepsis following trauma-induced hemorrhage.
Archives of surgery (Chicago, Ill. : 1960) 1998;133(12):1281-8.
1998: Chun-Shiang Chung; Y X Xu; W Wang; Irshad H Chaudry; Alfred Ayala
Is Fas ligand or endotoxin responsible for mucosal lymphocyte apoptosis in sepsis?
Archives of surgery (Chicago, Ill. : 1960) 1998;133(11):1213-20.
1998: M W Wichmann; Alfred Ayala; Irshad H Chaudry
Severe depression of host immune functions following closed-bone fracture, soft-tissue trauma, and hemorrhagic shock.
Critical care medicine 1998;26(8):1372-8.
1998: Chun-Shiang Chung; Y X Xu; Irshad H Chaudry; Alfred Ayala
Sepsis induces increased apoptosis in lamina propria mononuclear cells which is associated with altered cytokine gene expression.
The Journal of surgical research 1998;77(1):63-70.
1998: Martin K Angele; Alfred Ayala; William G Cioffi; Kirby I Bland; Irshad H Chaudry
Testosterone: the culprit for producing splenocyte immune depression after trauma hemorrhage.
The American journal of physiology 1998;274(6 Pt 1):C1530-6.
1998: T S Anantha Samy; Alfred Ayala; Robert A Catania; Irshad H Chaudry
Trauma-hemorrhage activates signal transduction pathways in mouse splenic T cells.
Shock (Augusta, Ga.) 1998;9(6):443-50.
1998: Alfred Ayala; TA Evans; Irshad H Chaudry
Does hepatocellular injury in sepsis involve apoptosis?
The Journal of surgical research 1998;76(2):165-73.
1998: Alfred Ayala; Y Xin Xu; C A Ayala; D E Sonefeld; S M Karr; TA Evans; Irshad H Chaudry
Increased mucosal B-lymphocyte apoptosis during polymicrobial sepsis is a Fas ligand but not an endotoxin-mediated process.
Blood 1998;91(4):1362-72.
1998: Y X Xu; Alfred Ayala; Irshad H Chaudry
Prolonged immunodepression after trauma and hemorrhagic shock.
The Journal of trauma 1998;44(2):335-41.
1998: Martin K Angele; Alfred Ayala; B A Monfils; William G Cioffi; Kirby I Bland; Irshad H Chaudry
Testosterone and/or low estradiol: normally required but harmful immunologically for males after trauma-hemorrhage.
The Journal of trauma 1998;44(1):78-85.
1998: R Zellweger; MW Wichmann; Alfred Ayala; Irshad H Chaudry
Metoclopramide: a novel and safe immunomodulating agent for restoring the depressed macrophage immune function after hemorrhage.
The Journal of trauma 1998;44(1):70-7.
1997: R G Molnar; Ping Wang; Alfred Ayala; Patricia E Ganey; Robert A Roth; Irshad H Chaudry
The role of neutrophils in producing hepatocellular dysfunction during the hyperdynamic stage of sepsis in rats.
The Journal of surgical research 1997;73(2):117-22.
1997: Martin K Angele; MW Wichmann; Alfred Ayala; William G Cioffi; Irshad H Chaudry
Testosterone receptor blockade after hemorrhage in males. Restoration of the depressed immune functions and improved survival following subsequent sepsis.
Archives of surgery (Chicago, Ill. : 1960) 1997;132(11):1207-14.
1997: MW Wichmann; Alfred Ayala; Irshad H Chaudry
Male sex steroids are responsible for depressing macrophage immune function after trauma-hemorrhage.
The American journal of physiology 1997;273(4 Pt 1):C1335-40.
1997: MW Wichmann; Martin K Angele; Alfred Ayala; William G Cioffi; Irshad H Chaudry
Flutamide: a novel agent for restoring the depressed cell-mediated immunity following soft-tissue trauma and hemorrhagic shock.
Shock (Augusta, Ga.) 1997;8(4):242-8.
1997: T E Williams; Alfred Ayala; Irshad H Chaudry
Inducible macrophage apoptosis following sepsis is mediated by cysteine protease activation and nitric oxide release.
The Journal of surgical research 1997;70(2):113-8.
1997: Y X Xu; Alfred Ayala; B Monfils; William G Cioffi; Irshad H Chaudry
Mechanism of intestinal mucosal immune dysfunction following trauma-hemorrhage: increased apoptosis associated with elevated Fas expression in Peyer's patches.
The Journal of surgical research 1997;70(1):55-60.
1997: X H Zhu; R Zellweger; MW Wichmann; Alfred Ayala; Irshad H Chaudry
Effects of prolactin and metoclopramide on macrophage cytokine gene expression in late sepsis.
Cytokine 1997;9(6):437-46.
1997: Alfred Ayala; P J O'Neill; S A Uebele; C D Herdon; Irshad H Chaudry
Mechanism of splenic immunosuppression during sepsis: key role of Kupffer cell mediators.
The Journal of trauma 1997;42(5):882-8.
1997: Alfred Ayala; S M Karr; TA Evans; Irshad H Chaudry
Factors responsible for peritoneal granulocyte apoptosis during sepsis.
The Journal of surgical research 1997;69(1):67-75.
1997: Y X Xu; MW Wichmann; Alfred Ayala; William G Cioffi; Irshad H Chaudry
Trauma-hemorrhage induces increased thymic apoptosis while decreasing IL-3 release and increasing GM-CSF.
The Journal of surgical research 1997;68(1):24-30.
1997: R Zellweger; MW Wichmann; Alfred Ayala; S Stein; C M DeMaso; Irshad H Chaudry
Females in proestrus state maintain splenic immune functions and tolerate sepsis better than males.
Critical care medicine 1997;25(1):106-10.
1996: R Zellweger; X H Zhu; MW Wichmann; Alfred Ayala; C M DeMaso; Irshad H Chaudry
Prolactin administration following hemorrhagic shock improves macrophage cytokine release capacity and decreases mortality from subsequent sepsis.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(12):5748-54.
1996: MW Wichmann; R Zellweger; C M DeMaso; Alfred Ayala; Irshad H Chaudry
Enhanced immune responses in females, as opposed to decreased responses in males following haemorrhagic shock and resuscitation.
Cytokine 1996;8(11):853-63.
1996: Alfred Ayala; Y Tu; M W Flye; Irshad H Chaudry
Depressed splenic function after hemorrhage results from gastrointestinal tract stimulation of hepatic-mediator release. Correction with portacaval shunt.
Archives of surgery (Chicago, Ill. : 1960) 1996;131(11):1209-14; discussion 1215.
1996: MW Wichmann; R Zellweger; C M DeMaso; Alfred Ayala; Irshad H Chaudry
Mechanism of immunosuppression in males following trauma-hemorrhage. Critical role of testosterone.
Archives of surgery (Chicago, Ill. : 1960) 1996;131(11):1186-91; discussion 1191-2.
1996: MW Wichmann; J M Haisken; Alfred Ayala; Irshad H Chaudry
Melatonin administration following hemorrhagic shock decreases mortality from subsequent septic challenge.
The Journal of surgical research 1996;65(2):109-14.
1996: MW Wichmann; S P Arnoczky; C M DeMaso; Alfred Ayala; Irshad H Chaudry
Depressed osteoblast activity and increased osteocyte necrosis after closed bone fracture and hemorrhagic shock.
The Journal of trauma 1996;41(4):628-33.
1996: MW Wichmann; R Zellweger; C M DeMaso; Alfred Ayala; C Williams; Irshad H Chaudry
Immune function is more compromised after closed bone fracture and hemorrhagic shock than hemorrhage alone.
Archives of surgery (Chicago, Ill. : 1960) 1996;131(9):995-1000.
1996: MW Wichmann; R Zellweger; C M DeMaso; Alfred Ayala; Irshad H Chaudry
Increased melatonin levels after hemorrhagic shock in male and female C3H/HeN mice.
Experientia 1996;52(6):587-90.
1996: MW Wichmann; R Zellweger; Alfred Ayala; Irshad H Chaudry
Melatonin administration attenuates depressed immune functions trauma-hemorrhage.
The Journal of surgical research 1996;63(1):256-62.
1996: R Zellweger; MW Wichmann; Alfred Ayala; C M DeMaso; Irshad H Chaudry
Prolactin: a novel and safe immunomodulating hormone for the treatment of immunodepression following severe hemorrhage.
The Journal of surgical research 1996;63(1):53-8.
1996: Alfred Ayala; C D Herdon; D L Lehman; C A Ayala; Irshad H Chaudry
Differential induction of apoptosis in lymphoid tissues during sepsis: variation in onset, frequency, and the nature of the mediators.
Blood 1996;87(10):4261-75.
1996: Alfred Ayala; Irshad H Chaudry
Platelet activating factor and its role in trauma, shock, and sepsis.
New horizons (Baltimore, Md.) 1996;4(2):265-75.
1996: Alfred Ayala; M A Urbanich; C D Herdon; Irshad H Chaudry
Is sepsis-induced apoptosis associated with macrophage dysfunction?
The Journal of trauma 1996;40(4):568-73; discussion 573-4.
1996: X H Zhu; R Zellweger; Alfred Ayala; Irshad H Chaudry
Prolactin inhibits the increased cytokine gene expression in Kupffer cells following haemorrhage.
Cytokine 1996;8(2):134-40.
1996: Alfred Ayala; Irshad H Chaudry
Immune dysfunction in murine polymicrobial sepsis: mediators, macrophages, lymphocytes and apoptosis.
Shock (Augusta, Ga.) 1996;6 Suppl 1():S27-38.
1995: Alfred Ayala; Z K Deol; D L Lehman; C D Herdon; Irshad H Chaudry
Does endotoxin play a major role in inducing the depression of macrophage function during polymicrobial sepsis?
Archives of surgery (Chicago, Ill. : 1960) 1995;130(11):1178-84; discussion 1184-5.
1995: R Zellweger; Alfred Ayala; X L Zhu; M H Morrison; Irshad H Chaudry
Effect of surgical trauma on splenocyte and peritoneal macrophage immune function.
The Journal of trauma 1995;39(4):645-50.
1995: R Zellweger; Alfred Ayala; J F Schmand; M H Morrison; Irshad H Chaudry
PAF-antagonist administration after hemorrhage-resuscitation prevents splenocyte immunodepression.
The Journal of surgical research 1995;59(3):366-70.
1995: R Zellweger; Alfred Ayala; C M DeMaso; Irshad H Chaudry
Trauma-hemorrhage causes prolonged depression in cellular immunity.
Shock (Augusta, Ga.) 1995;4(2):149-53.
1995: W Ertel; M H Morrison; Alfred Ayala; Irshad H Chaudry
Hypoxemia in the absence of blood loss or significant hypotension causes inflammatory cytokine release.
The American journal of physiology 1995;269(1 Pt 2):R160-6.
1995: R Zellweger; Alfred Ayala; X L Zhu; K R Holme; C M DeMaso; Irshad H Chaudry
A novel nonanticoagulant heparin improves splenocyte and peritoneal macrophage immune function after trauma-hemorrhage and resuscitation.
The Journal of surgical research 1995;59(1):211-8.
1995: A Mayberry; Alfred Ayala; Irshad H Chaudry
Hemorrhage affects the ability of murine peritoneal macrophages to alkanize intracellular pH in acidic environments.
The Journal of surgical research 1995;58(6):682-6.
1995: J F Schmand; Alfred Ayala; M H Morrison; Irshad H Chaudry
Effects of hydroxyethyl starch after trauma-hemorrhagic shock: restoration of macrophage integrity and prevention of increased circulating interleukin-6 levels.
Critical care medicine 1995;23(5):806-14.
1995: Alfred Ayala; C D Herdon; D L Lehman; C M DeMaso; C A Ayala; Irshad H Chaudry
The induction of accelerated thymic programmed cell death during polymicrobial sepsis: control by corticosteroids but not tumor necrosis factor.
Shock (Augusta, Ga.) 1995;3(4):259-67.
1995: Irshad H Chaudry; R Zellweger; Alfred Ayala
The role of bacterial translocation on Kupffer cell immune function following hemorrhage.
Progress in clinical and biological research 1995;392():209-18.
1995: Alfred Ayala; Irshad H Chaudry
Dietary n-3 polyunsaturated fatty acid modulation of immune cell function before or after trauma.
Nutrition (Burbank, Los Angeles County, Calif.) 1995;11(1):1-11.
1995: X L Zhu; R Zellweger; X H Zhu; Alfred Ayala; Irshad H Chaudry
Cytokine gene expression in splenic macrophages and Kupffer cells following haemorrhage.
Cytokine 1995;7(1):8-14.
1994: J F Schmand; Alfred Ayala; M H Morrison; Irshad H Chaudry
Dextran 70 administration after trauma-hemorrhagic shock does not impair cellular immune functions.
Journal of critical care 1994;9(4):244-54.
1994: Alfred Ayala; D L Lehman; C D Herdon; Irshad H Chaudry
Mechanism of enhanced susceptibility to sepsis following hemorrhage. Interleukin-10 suppression of T-cell response is mediated by eicosanoid-induced interleukin-4 release.
Archives of surgery (Chicago, Ill. : 1960) 1994;129(11):1172-8.
1994: W Ertel; M H Morrison; Alfred Ayala; Irshad H Chaudry
Biological significance of elevated TNF levels: in vivo administration of monoclonal antibody against tnf following haemorrhage shock increases the capacity of macrophages to release TNF while restoring immunoresponsiveness.
Cytokine 1994;6(6):624-32.
1994: X L Zhu; Alfred Ayala; R Zellweger; M H Morrison; Irshad H Chaudry
Peritoneal macrophages show increased cytokine gene expression following haemorrhagic shock.
Immunology 1994;83(3):378-83.
1994: J F Schmand; Alfred Ayala; Irshad H Chaudry
Effects of trauma, duration of hypotension, and resuscitation regimen on cellular immunity after hemorrhagic shock.
Critical care medicine 1994;22(7):1076-83.
1994: Alfred Ayala; Z K Deol; D L Lehman; C D Herdon; Irshad H Chaudry
Polymicrobial sepsis but not low-dose endotoxin infusion causes decreased splenocyte IL-2/IFN-gamma release while increasing IL-4/IL-10 production.
The Journal of surgical research 1994;56(6):579-85.
1994: H J Lindsey; J M Kisala; Alfred Ayala; D Lehman; C D Herdon; Irshad H Chaudry
Pentoxifylline attenuates oxygen-induced lung injury.
The Journal of surgical research 1994;56(6):543-8.
1994: D R Meldrum; Alfred Ayala; Irshad H Chaudry
Energetics of lymphocyte "burnout" in late sepsis: adjuvant treatment with ATP-MgCl2 improves energetics and decreases lethality.
The Journal of surgical research 1994;56(6):537-42.
1994: P J O'Neill; L M Cobb; Alfred Ayala; M H Morrison; Irshad H Chaudry
Aggressive fluid resuscitation following intestinal ischemia-reperfusion in immature rats prevents metabolic derangements and down regulates interleukin-6 release.
Shock (Augusta, Ga.) 1994;1(5):381-7.
1994: Alfred Ayala; Irshad H Chaudry
Hemorrhage induces a reduction in the capacity of macrophages to mobilize intracellular calcium secondary to formyl-methionyl-leucyl-phenylalanine stimulation: association with alterations in cells surface Fc receptor expression and increased prostaglandin release.
Shock (Augusta, Ga.) 1994;1(3):228-35.
1994: Ping Wang; Zheng F Ba; M C Lu; Alfred Ayala; J M Harkema; Irshad H Chaudry
Measurement of circulating blood volume in vivo after trauma-hemorrhage and hemodilution.
The American journal of physiology 1994;266(2 Pt 2):R368-74.
1994: P J O'Neill; Alfred Ayala; Ping Wang; Zheng F Ba; M H Morrison; A E Schultze; S S Reich; Irshad H Chaudry
Role of Kupffer cells in interleukin-6 release following trauma-hemorrhage and resuscitation.
Shock (Augusta, Ga.) 1994;1(1):43-7.
1993: X Zhu; W Ertel; Alfred Ayala; M H Morrison; M M Perrin; Irshad H Chaudry
Chloroquine inhibits macrophage tumour necrosis factor-alpha mRNA transcription.
Immunology 1993;80(1):122-6.
1993: D R Meldrum; Alfred Ayala; Irshad H Chaudry
Mechanism of diltiazem's immunomodulatory effects after hemorrhage and resuscitation.
The American journal of physiology 1993;265(2 Pt 1):C412-21.
1993: Alfred Ayala; D R Meldrum; M M Perrin; Irshad H Chaudry
The release of transforming growth factor-beta following haemorrhage: its role as a mediator of host immunosuppression.
Immunology 1993;79(3):479-84.
1993: Ping Wang; Alfred Ayala; Zheng F Ba; M Zhou; M M Perrin; Irshad H Chaudry
Tumor necrosis factor-alpha produces hepatocellular dysfunction despite normal cardiac output and hepatic microcirculation.
The American journal of physiology 1993;265(1 Pt 1):G126-32.
1993: W Ertel; G Singh; M H Morrison; Alfred Ayala; Irshad H Chaudry
Chemically induced hypotension increases PGE2 release and depresses macrophage antigen presentation.
The American journal of physiology 1993;264(4 Pt 2):R655-60.
1993: Alfred Ayala; Ping Wang; Irshad H Chaudry
Insights into the mechanism by which interferon-gamma improves macrophage function following hemorrhage and resuscitation.
The Journal of surgical research 1993;54(4):322-7.
1993: J M Kisala; Alfred Ayala; R N Stephan; Irshad H Chaudry
A model of pulmonary atelectasis in rats: activation of alveolar macrophage and cytokine release.
The American journal of physiology 1993;264(3 Pt 2):R610-4.
1993: Alfred Ayala; J B Knotts; W Ertèl; M M Perrin; M H Morrison; Irshad H Chaudry
Role of interleukin 6 and transforming growth factor-beta in the induction of depressed splenocyte responses following sepsis.
Archives of surgery (Chicago, Ill. : 1960) 1993;128(1):89-94; discussion 94-5.
1993: W Ertel; M H Morrison; Alfred Ayala; Irshad H Chaudry
Modulation of macrophage membrane phospholipids by n-3 polyunsaturated fatty acids increases interleukin 1 release and prevents suppression of cellular immunity following hemorrhagic shock.
Archives of surgery (Chicago, Ill. : 1960) 1993;128(1):15-20; discussion 20-1.
1992: Ping Wang; Zheng F Ba; M H Morrison; Alfred Ayala; Irshad H Chaudry
Mechanism of the beneficial effects of pentoxifylline on hepatocellular function after trauma hemorrhage and resuscitation.
Surgery 1992;112(2):451-7; discussion 457-8.
1992: D R Meldrum; Alfred Ayala; Irshad H Chaudry
Energetics of defective macrophage antigen presentation after hemorrhage as determined by ultraresolution 31P nuclear magnetic resonance spectrometry: restoration with adenosine triphosphate-MgCl2.
Surgery 1992;112(2):150-6; discussion 156-8.
1992: W Ertel; M H Morrison; D R Meldrum; Alfred Ayala; Irshad H Chaudry
Ibuprofen restores cellular immunity and decreases susceptibility to sepsis following hemorrhage.
The Journal of surgical research 1992;53(1):55-61.
1992: Alfred Ayala; M M Perrin; Ping Wang; Irshad H Chaudry
Sepsis induces an early increased spontaneous release of hepatocellular stimulatory factor (interleukin-6) by Kupffer cells in both endotoxin tolerant and intolerant mice.
The Journal of surgical research 1992;52(6):635-41.
1992: Ping Wang; Zheng F Ba; M H Morrison; Alfred Ayala; R E Dean; Irshad H Chaudry
Mechanism of the beneficial effects of ATP-MgCl2 following trauma-hemorrhage and resuscitation: downregulation of inflammatory cytokine (TNF, IL-6) release.
The Journal of surgical research 1992;52(4):364-71.
1992: M W Rana; G Singh; Ping Wang; Alfred Ayala; M Zhou; Irshad H Chaudry
Protective effects of preheparinization on the microvasculature during and after hemorrhagic shock.
The Journal of trauma 1992;32(4):420-6.
1992: Alfred Ayala; M M Perrin; J M Kisala; W Ertel; Irshad H Chaudry
Polymicrobial sepsis selectively activates peritoneal but not alveolar macrophages to release inflammatory mediators (interleukins-1 and -6 and tumor necrosis factor).
Circulatory shock 1992;36(3):191-9.
1992: Ping Wang; M Zhou; M W Rana; G Singh; Zheng F Ba; Alfred Ayala; Irshad H Chaudry
ATP-MgCl2 restores renal microcirculation following trauma and severe hemorrhage.
Canadian journal of physiology and pharmacology 1992;70(3):349-57.
1992: Ping Wang; Zheng F Ba; Alfred Ayala; Irshad H Chaudry
Hepatocellular dysfunction persists during early sepsis despite increased volume of crystalloid resuscitation.
The Journal of trauma 1992;32(3):389-96; discussion 396-7.
1992: W Ertel; M H Morrison; Alfred Ayala; R E Dean; Irshad H Chaudry
Interferon-gamma attenuates hemorrhage-induced suppression of macrophage and splenocyte functions and decreases susceptibility to sepsis.
Surgery 1992;111(2):177-87.
1992: Alfred Ayala; J M Kisala; J A Felt; M M Perrin; Irshad H Chaudry
Does endotoxin tolerance prevent the release of inflammatory monokines (interleukin 1, interleukin 6, or tumor necrosis factor) during sepsis?
Archives of surgery (Chicago, Ill. : 1960) 1992;127(2):191-6; discussion 196-7.
1992: W Ertel; M H Morrison; Alfred Ayala; Irshad H Chaudry
Chloroquine attenuates hemorrhagic shock-induced immunosuppression and decreases susceptibility to sepsis.
Archives of surgery (Chicago, Ill. : 1960) 1992;127(1):70-5; discussion 75-6.
1992: Alfred Ayala; M M Perrin; W Ertel; Irshad H Chaudry
Differential effects of hemorrhage on Kupffer cells: decreased antigen presentation despite increased inflammatory cytokine (IL-1, IL-6 and TNF) release.
Cytokine 1992;4(1):66-75.
1991: Alfred Ayala; M M Perrin; Ping Wang; W Ertel; Irshad H Chaudry
Hemorrhage induces enhanced Kupffer cell cytotoxicity while decreasing peritoneal or splenic macrophage capacity. Involvement of cell-associated tumor necrosis factor and reactive nitrogen.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(12):4147-54.
1991: W Ertel; M H Morrison; Alfred Ayala; Irshad H Chaudry
Chloroquine attenuates hemorrhagic shock-induced suppression of Kupffer cell antigen presentation and major histocompatibility complex class II antigen expression through blockade of tumor necrosis factor and prostaglandin release.
Blood 1991;78(7):1781-8.
1991: W Ertel; M H Morrison; Alfred Ayala; M M Perrin; Irshad H Chaudry
Anti-TNF monoclonal antibodies prevent haemorrhage-induced suppression of Kupffer cell antigen presentation and MHC class II antigen expression.
Immunology 1991;74(2):290-7.
1991: D R Meldrum; Alfred Ayala; M M Perrin; W Ertel; Irshad H Chaudry
Diltiazem restores IL-2, IL-3, IL-6, and IFN-gamma synthesis and decreases host susceptibility to sepsis following hemorrhage.
The Journal of surgical research 1991;51(2):158-64.
1991: D R Meldrum; Alfred Ayala; Ping Wang; W Ertel; Irshad H Chaudry
Association between decreased splenic ATP levels and immunodepression: amelioration with ATP-MgCl2.
The American journal of physiology 1991;261(2 Pt 2):R351-7.
1991: W Ertel; M H Morrison; Ping Wang; Zheng F Ba; Alfred Ayala; Irshad H Chaudry
The complex pattern of cytokines in sepsis. Association between prostaglandins, cachectin, and interleukins.
Annals of surgery 1991;214(2):141-8.
1991: W Ertel; M H Morrison; Alfred Ayala; Irshad H Chaudry
Insights into the mechanisms of defective antigen presentation after hemorrhage.
Surgery 1991;110(2):440-5; discussion 445-7.
1991: W Ertel; M H Morrison; Alfred Ayala; Irshad H Chaudry
Eicosanoids regulate tumor necrosis factor synthesis after hemorrhage in vitro and in vivo.
The Journal of trauma 1991;31(5):609-15; discussion 615-6.
1991: Ping Wang; Alfred Ayala; R E Dean; Joe G Hauptman; Zheng F Ba; G K DeJong; Irshad H Chaudry
Adequate crystalloid resuscitation restores but fails to maintain the active hepatocellular function following hemorrhagic shock.
The Journal of trauma 1991;31(5):601-7; discussion 607-8.
1991: W Ertel; M H Morrison; Alfred Ayala; M M Perrin; Irshad H Chaudry
Blockade of prostaglandin production increases cachectin synthesis and prevents depression of macrophage functions after hemorrhagic shock.
Annals of surgery 1991;213(3):265-71.
1991: Alfred Ayala; Ping Wang; Zheng F Ba; M M Perrin; W Ertel; Irshad H Chaudry
Differential alterations in plasma IL-6 and TNF levels after trauma and hemorrhage.
The American journal of physiology 1991;260(1 Pt 2):R167-71.
1990: M W Rana; Alfred Ayala; R E Dean; Irshad H Chaudry
Decreased Fc receptor expression on macrophages following simple hemorrhage as observed by scanning immunoelectron microscopy.
Journal of leukocyte biology 1990;48(6):512-8.
1990: W Ertel; D R Meldrum; M H Morrison; Alfred Ayala; Irshad H Chaudry
Immunoprotective effect of a calcium channel blocker on macrophage antigen presentation function, major histocompatability class II antigen expression, and interleukin-1 synthesis after hemorrhage.
Surgery 1990;108(2):154-9; discussion 159-60.
1990: Alfred Ayala; M M Perrin; Irshad H Chaudry
Defective macrophage antigen presentation following haemorrhage is associated with the loss of MHC class II (Ia) antigens.
Immunology 1990;70(1):33-9.
1990: Alfred Ayala; M M Perrin; D R Meldrum; W Ertel; Irshad H Chaudry
Hemorrhage induces an increase in serum TNF which is not associated with elevated levels of endotoxin.
Cytokine 1990;2(3):170-4.
1990: Alfred Ayala; M M Perrin; M A Wagner; Irshad H Chaudry
Enhanced susceptibility to sepsis after simple hemorrhage. Depression of Fc and C3b receptor-mediated phagocytosis.
Archives of surgery (Chicago, Ill. : 1960) 1990;125(1):70-4; discussion 74-5.
1989: R N Stephan; Alfred Ayala; J M Harkema; R E Dean; J R Border; Irshad H Chaudry
Mechanism of immunosuppression following hemorrhage: defective antigen presentation by macrophages.
The Journal of surgical research 1989;46(6):553-6.