Takeshi Iwatsubo

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Disorders

Alzheimer Disease

Chemicals & Drugs

Anatomy

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Publications

TOP 3
Yokoshima Satoshi; Abe Yuzo; Watanabe Naoto; Kita Yoichi; Kan Toshiyuki; Iwatsubo Takeshi; Tomita Taisuke; Fukuyama Tohru
Development of photoaffinity probes for gamma-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker.
Kamikawaji Shogo; Ito Genta; Iwatsubo Takeshi
Identification of the autophosphorylation sites of LRRK2.
Hayashi Ikuo; Takatori Sho; Urano Yasuomi; Iwanari Hiroko; Isoo Noriko; Osawa Satoko; Fukuda Maiko A; Kodama Tatsuhiko; Hamakubo Takao; Li Tong; Wong Philip C; Tomita Taisuke; Iwatsubo Takeshi
Single chain variable fragment against nicastrin inhibits the gamma-secretase activity.

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All Publications

2009: Yokoshima Satoshi; Abe Yuzo; Watanabe Naoto; Kita Yoichi; Kan Toshiyuki; Iwatsubo Takeshi; Tomita Taisuke; Fukuyama Tohru
Development of photoaffinity probes for gamma-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker.
Bioorganic & medicinal chemistry letters 2009;19(24):6869-71.
2009: Kamikawaji Shogo; Ito Genta; Iwatsubo Takeshi
Identification of the autophosphorylation sites of LRRK2.
Biochemistry 2009;48(46):10963-75.
2009: Hayashi Ikuo; Takatori Sho; Urano Yasuomi; Iwanari Hiroko; Isoo Noriko; Osawa Satoko; Fukuda Maiko A; Kodama Tatsuhiko; Hamakubo Takao; Li Tong; Wong Philip C; Tomita Taisuke; Iwatsubo Takeshi
Single chain variable fragment against nicastrin inhibits the gamma-secretase activity.
The Journal of biological chemistry 2009;284(41):27838-47.
2009: Yamada Kaoru; Yabuki Chiori; Seubert Peter; Schenk Dale; Hori Yukiko; Ohtsuki Sumio; Terasaki Tetsuya; Hashimoto Tadafumi; Iwatsubo Takeshi
Abeta immunotherapy: intracerebral sequestration of Abeta by an anti-Abeta monoclonal antibody 266 with high affinity to soluble Abeta.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(36):11393-8.
2009: Imamura Yuki; Watanabe Naoto; Umezawa Naoki; Iwatsubo Takeshi; Kato Nobuki; Tomita Taisuke; Higuchi Tsunehiko
Inhibition of gamma-secretase activity by helical beta-peptide foldamers.
Journal of the American Chemical Society 2009;131(21):7353-9.
2009: Cheng Haipeng; Vetrivel Kulandaivelu S; Drisdel Renaldo C; Meckler Xavier; Gong Ping; Leem Jae Yoon; Li Tong; Carter Meghan; Chen Ying; Nguyen Phuong; Iwatsubo Takeshi; Tomita Taisuke; Wong Philip C; Green William N; Kounnas Maria Z; Thinakaran Gopal
S-palmitoylation of gamma-secretase subunits nicastrin and APH-1.
The Journal of biological chemistry 2009;284(3):1373-84.
2008: Yamada Kaoru; Hashimoto Tadafumi; Yabuki Chiori; Nagae Yusuke; Tachikawa Masanori; Strickland Dudley K; Liu Qiang; Bu Guojun; Basak Jacob M; Holtzman David M; Ohtsuki Sumio; Terasaki Tetsuya; Iwatsubo Takeshi
The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid beta peptides in an in vitro model of the blood-brain barrier cells.
The Journal of biological chemistry 2008;283(50):34554-62.
2008: Ikemura Masako; Saito Yuko; Sengoku Renpei; Sakiyama Yoshio; Hatsuta Hiroyuki; Kanemaru Kazutomi; Sawabe Motoji; Arai Tomio; Ito Genta; Iwatsubo Takeshi; Fukayama Masashi; Murayama Shigeo
Lewy body pathology involves cutaneous nerves.
Journal of neuropathology and experimental neurology 2008;67(10):945-53.
2008: Kuwahara Tomoki; Koyama Akihiko; Koyama Shingo; Yoshina Sawako; Ren Chang-Hong; Kato Takeo; Mitani Shohei; Iwatsubo Takeshi
A systematic RNAi screen reveals involvement of endocytic pathway in neuronal dysfunction in alpha-synuclein transgenic C. elegans.
Human molecular genetics 2008;17(19):2997-3009.
2008: Lo Bianco Christophe; Shorter James; Régulier Etienne; Lashuel Hilal; Iwatsubo Takeshi; Lindquist Susan; Aebischer Patrick
Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease.
The Journal of clinical investigation 2008;118(9):3087-97.
2008: Beach Thomas G; White Charles L; Hamilton Ronald L; Duda John E; Iwatsubo Takeshi; Dickson Dennis W; Leverenz James B; Roncaroli Federico; Buttini Manuel; Hladik Christa L; Sue Lucia I; Noorigian Joseph V; Adler Charles H
Evaluation of alpha-synuclein immunohistochemical methods used by invited experts.
Acta neuropathologica 2008;116(3):277-88.
2008: Cheung King-Ho; Shineman Diana; Müller Marioly; Cárdenas César; Mei Lijuan; Yang Jun; Tomita Taisuke; Iwatsubo Takeshi; Lee Virginia M-Y; Foskett J Kevin
Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating.
Neuron 2008;58(6):871-83.
2008: Sato Chihiro; Takagi Shizuka; Tomita Taisuke; Iwatsubo Takeshi
The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(24):6264-71.
2008: Akanuma Shin-ichi; Ohtsuki Sumio; Doi Youko; Tachikawa Masanori; Ito Shingo; Hori Satoko; Asashima Tomoko; Hashimoto Tadafumi; Yamada Kaoru; Ueda Kazumitsu; Iwatsubo Takeshi; Terasaki Tetsuya
ATP-binding cassette transporter A1 (ABCA1) deficiency does not attenuate the brain-to-blood efflux transport of human amyloid-beta peptide (1-40) at the blood-brain barrier.
Neurochemistry international 2008;52(6):956-61.
2008: Ikeuchi Takeshi; Kakita Akiyoshi; Shiga Atsushi; Kasuga Kensaku; Kaneko Hiryoyuki; Tan Chun-Feng; Idezuka Jiro; Wakabayashi Koichi; Onodera Osamu; Iwatsubo Takeshi; Nishizawa Masatoyo; Takahashi Hitoshi; Ishikawa Atsushi
Patients homozygous and heterozygous for SNCA duplication in a family with parkinsonism and dementia.
Archives of neurology 2008;65(4):514-9.
2008: Yoshihara Tomoki; Takiguchi Sho; Kyuno Akifumi; Tanaka Koichi; Kuba Sayaka; Hashiguchi Shuhei; Ito Yuji; Hashimoto Tadafumi; Iwatsubo Takeshi; Tsuyama Shinichiro; Nakashima Toshihiro; Sugimura Kazuhisa
Immunoreactivity of phage library-derived human single-chain antibodies to amyloid beta conformers in vitro.
Journal of biochemistry 2008;143(4):475-86.
2008: Obi Kimiko; Akiyama Haruhiko; Kondo Hiromi; Shimomura Yoko; Hasegawa Masato; Iwatsubo Takeshi; Mizuno Yoshikuni; Mochizuki Hideki
Relationship of phosphorylated alpha-synuclein and tau accumulation to Abeta deposition in the cerebral cortex of dementia with Lewy bodies.
Experimental neurology 2008;210(2):409-20.
2008: Wakamatsu Masaki; Ishii Aiko; Iwata Shingo; Sakagami Junko; Ukai Yuriko; Ono Mieko; Kanbe Daiji; Muramatsu Shin-ichi; Kobayashi Kazuto; Iwatsubo Takeshi; Yoshimoto Makoto
Selective loss of nigral dopamine neurons induced by overexpression of truncated human alpha-synuclein in mice.
Neurobiology of aging 2008;29(4):574-85.
2008: Ichibangase Tomoko; Saimaru Hiroshi; Takamura Norio; Kuwahara Tomoki; Koyama Akihiko; Iwatsubo Takeshi; Imai Kazuhiro
Proteomics of Caenorhabditis elegans over-expressing human alpha-synuclein analyzed by fluorogenic derivatization-liquid chromatography/tandem mass spectrometry: identification of actin and several ribosomal proteins as negative markers at early Parkinson's disease stages.
Biomedical chromatography : BMC 2008;22(3):232-4.
2008: Kumano Keiki; Masuda Shigeo; Sata Masataka; Saito Toshiki; Lee Suk-Young; Sakata-Yanagimoto Mamiko; Tomita Taisuke; Iwatsubo Takeshi; Natsugari Hideaki; Kurokawa Mineo; Ogawa Seishi; Chiba Shigeru
Both Notch1 and Notch2 contribute to the regulation of melanocyte homeostasis.
Pigment cell & melanoma research 2008;21(1):70-8.
2008: Takatori Sho; Ito Genta; Iwatsubo Takeshi
Cytoplasmic localization and proteasomal degradation of N-terminally cleaved form of PINK1.
Neuroscience letters 2008;430(1):13-7.
2008: Perry George; Zhu Xiongwei; Babar Asim K; Siedlak Sandra L; Yang Qiwei; Ito Genta; Iwatsubo Takeshi; Smith Mark A; Chen Shu G
Leucine-rich repeat kinase 2 colocalizes with alpha-synuclein in Parkinson's disease, but not tau-containing deposits in tauopathies.
Neuro-degenerative diseases 2008;5(3-4):222-4.
2007: Kaneko Hiroyuki; Kakita Akiyoshi; Kasuga Kensaku; Nozaki Hiroaki; Ishikawa Atsushi; Miyashita Akinori; Kuwano Ryozo; Ito Genta; Iwatsubo Takeshi; Takahashi Hitoshi; Nishizawa Masatoyo; Onodera Osamu; Sisodia Sangram S; Ikeuchi Takeshi
Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(48):13092-7.
2007: Sasakawa Hiroaki; Sakata Eri; Yamaguchi Yoshiki; Masuda Masami; Mori Tetsuya; Kurimoto Eiji; Iguchi Takeshi; Hisanaga Shin-ichi; Iwatsubo Takeshi; Hasegawa Masato; Kato Koichi
Ultra-high field NMR studies of antibody binding and site-specific phosphorylation of alpha-synuclein.
Biochemical and biophysical research communications 2007;363(3):795-9.
2007: Iwatsubo Takeshi
Pathological biochemistry of alpha-synucleinopathy.
Neuropathology : official journal of the Japanese Society of Neuropathology 2007;27(5):474-8.
2007: Ishii Aasami; Nonaka Takashi; Taniguchi Sayuri; Saito Taro; Arai Tetsuaki; Mann David; Iwatsubo Takeshi; Hisanaga Shin-Ichi; Goedert Michel; Hasegawa Masato
Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alpha-synuclein: Implication for alpha-synucleinopathies.
FEBS letters 2007;581(24):4711-7.
2007: Kato Masaru; Kinoshita Hiroyuki; Enokita Mitsue; Hori Yukiko; Hashimoto Tadafumi; Iwatsubo Takeshi; Toyo'oka Toshimasa
Analytical method for beta-amyloid fibrils using CE-laser induced fluorescence and its application to screening for inhibitors of beta-amyloid protein aggregation.
Analytical chemistry 2007;79(13):4887-91.
2007: Fuwa Haruhiko; Takahashi Yasuko; Konno Yu; Watanabe Naoto; Miyashita Hiroyuki; Sasaki Makoto; Natsugari Hideaki; Kan Toshiyuki; Fukuyama Tohru; Tomita Taisuke; Iwatsubo Takeshi
Divergent synthesis of multifunctional molecular probes to elucidate the enzyme specificity of dipeptidic gamma-secretase inhibitors.
ACS chemical biology 2007;2(6):408-18.
2007: Wakamatsu Masaki; Ishii Aiko; Ukai Yuriko; Sakagami Junko; Iwata Shingo; Ono Mieko; Matsumoto Kayo; Nakamura Atsushi; Tada Norihiro; Kobayashi Kazuto; Iwatsubo Takeshi; Yoshimoto Makoto
Accumulation of phosphorylated alpha-synuclein in dopaminergic neurons of transgenic mice that express human alpha-synuclein.
Journal of neuroscience research 2007;85(8):1819-25.
2007: Fumimura Yuichi; Ikemura Masako; Saito Yuko; Sengoku Renpei; Kanemaru Kazutomi; Sawabe Motoji; Arai Tomio; Ito Genta; Iwatsubo Takeshi; Fukayama Masashi; Mizusawa Hidehiro; Murayama Shigeo
Analysis of the adrenal gland is useful for evaluating pathology of the peripheral autonomic nervous system in lewy body disease.
Journal of neuropathology and experimental neurology 2007;66(5):354-62.
2007: Kan Toshiyuki; Kita Yoichi; Morohashi Yuichi; Tominari Yusuke; Hosoda Shinnosuke; Tomita Taisuke; Natsugari Hideaki; Iwatsubo Takeshi; Fukuyama Tohru
Convenient synthesis of photoaffinity probes and evaluation of their labeling abilities.
Organic letters 2007;9(11):2055-8.
2007: Haleem Kamran; Lippa Carol F; Smith Thomas W; Kowa Hisatomo; Wu Jianlin; Iwatsubo Takeshi
Presenilin-1 C410Y Alzheimer disease plaques contain synaptic proteins.
American journal of Alzheimer's disease and other dementias 2007;22(2):137-44.
2007: Isoo Noriko; Sato Chihiro; Miyashita Hiroyuki; Shinohara Mitsuru; Takasugi Nobumasa; Morohashi Yuichi; Tsuji Shoji; Tomita Taisuke; Iwatsubo Takeshi
Abeta42 overproduction associated with structural changes in the catalytic pore of gamma-secretase: common effects of Pen-2 N-terminal elongation and fenofibrate.
The Journal of biological chemistry 2007;282(17):12388-96.
2007: Lippa C F; Duda J E; Grossman M; Hurtig H I; Aarsland D; Boeve B F; Brooks D J; Dickson D W; Dubois B; Emre M; Fahn S; Farmer J M; Galasko D; Galvin J E; Goetz C G; Growdon J H; Gwinn-Hardy K A; Hardy J; Heutink P; Iwatsubo T; Kosaka K; Lee V M-Y; Leverenz J B; Masliah E; McKeith I G; Nussbaum R L; Olanow C W; Ravina B M; Singleton A B; Tanner C M; Trojanowski J Q; Wszolek Z K;
DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers.
Neurology 2007;68(11):812-9.
2007: Yamamoto Ryoko; Iseki Eizo; Murayama Norio; Minegishi Michiko; Marui Wami; Togo Takashi; Katsuse Omi; Kosaka Kenji; Kato Masanori; Iwatsubo Takeshi; Arai Heii
Correlation in Lewy pathology between the claustrum and visual areas in brains of dementia with Lewy bodies.
Neuroscience letters 2007;415(3):219-24.
2007: Ito Genta; Okai Takuro; Fujino Go; Takeda Kohsuke; Ichijo Hidenori; Katada Toshiaki; Iwatsubo Takeshi
GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease.
Biochemistry 2007;46(5):1380-8.
2007: Hori Yukiko; Hashimoto Tadafumi; Wakutani Yosuke; Urakami Katsuya; Nakashima Kenji; Condron Margaret M; Tsubuki Satoshi; Saido Takaomi C; Teplow David B; Iwatsubo Takeshi
The Tottori (D7N) and English (H6R) familial Alzheimer disease mutations accelerate Abeta fibril formation without increasing protofibril formation.
The Journal of biological chemistry 2007;282(7):4916-23.
2006: Hsieh Helen; Boehm Jannic; Sato Chihiro; Iwatsubo Takeshi; Tomita Taisuke; Sisodia Sangram; Malinow Roberto
AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss.
Neuron 2006;52(5):831-43.
2006: Ozaki Toshinori; Li Yuanyuan; Kikuchi Hironobu; Tomita Taisuke; Iwatsubo Takeshi; Nakagawara Akira
The intracellular domain of the amyloid precursor protein (AICD) enhances the p53-mediated apoptosis.
Biochemical and biophysical research communications 2006;351(1):57-63.
2006: Iwatsubo Takeshi
[Beta- and gamma-secretases]
Rinsho shinkeigaku = Clinical neurology 2006;46(11):925-6.
2006: Sato Chihiro; Morohashi Yuichi; Tomita Taisuke; Iwatsubo Takeshi
Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(46):12081-8.
2006: Kim Eun Joo; Sung Jee Young; Lee Hyun Jung; Rhim Hyewhon; Hasegawa Masato; Iwatsubo Takeshi; Min Do Sik; Kim Jongsun; Paik Seung R; Chung Kwang Chul
Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation.
The Journal of biological chemistry 2006;281(44):33250-7.
2006: Iwatsubo Takeshi
Tauopathy: an overview.
Neuropathology : official journal of the Japanese Society of Neuropathology 2006;26(5):455-6.
2006: Arawaka Shigeki; Wada Manabu; Goto Saori; Karube Hiroki; Sakamoto Masahiro; Ren Chang-Hong; Koyama Shingo; Nagasawa Hikaru; Kimura Hideki; Kawanami Toru; Kurita Keiji; Tajima Katsushi; Daimon Makoto; Baba Masanori; Kido Takashi; Saino Sachiko; Goto Kaoru; Asao Hironobu; Kitanaka Chihumi; Takashita Emi; Hongo Seiji; Nakamura Takao; Kayama Takamasa; Suzuki Yoshihiro; Kobayashi Kazuo; Katagiri Tadashi; Kurokawa Katsuro; Kurimura Masayuki; Toyoshima Itaru; Niizato Kazuhiro; Tsuchiya Kuniaki; Iwatsubo Takeshi; Muramatsu Masaaki; Matsumine Hiroto; Kato Takeo
The role of G-protein-coupled receptor kinase 5 in pathogenesis of sporadic Parkinson's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(36):9227-38.
2006: Shiarli A-M; Jennings R; Shi J; Bailey K; Davidson Y; Tian J; Bigio E H; Ghetti B; Murrell J R; Delisle M B; Mirra S; Crain B; Zolo P; Arima K; Iseki E; Murayama S; Kretzschmar H; Neumann M; Lippa C; Halliday G; Mackenzie J; Khan N; Ravid R; Dickson D; Wszolek Z; Iwatsubo T; Pickering-Brown S M; Mann D M A
Comparison of extent of tau pathology in patients with frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17), frontotemporal lobar degeneration with Pick bodies and early onset Alzheimer's disease.
Neuropathology and applied neurobiology 2006;32(4):374-87.
2006: Fuwa Haruhiko; Hiromoto Kenichi; Takahashi Yasuko; Yokoshima Satoshi; Kan Toshiyuki; Fukuyama Tohru; Iwatsubo Takeshi; Tomita Taisuke; Natsugari Hideaki
Synthesis of biotinylated photoaffinity probes based on arylsulfonamide gamma-secretase inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(16):4184-9.
2006: Iwatsubo Takeshi; Ihara Yasuo; Kanazawa Ichiro
Alzheimer disease research in Japan: public funding.
Nature medicine 2006;12(7):778-9.
2006: Garino Cédrik; Tomita Taisuke; Pietrancosta Nicolas; Laras Younes; Rosas Roselyne; Herbette Gaëtan; Maigret Bernard; Quéléver Gilles; Iwatsubo Takeshi; Kraus Jean-Louis
Naphthyl and coumarinyl biarylpiperazine derivatives as highly potent human beta-secretase inhibitors. Design, synthesis, and enzymatic BACE-1 and cell assays.
Journal of medicinal chemistry 2006;49(14):4275-85.
2006: Tamaki Chihiro; Ohtsuki Sumio; Iwatsubo Takeshi; Hashimoto Tadafumi; Yamada Kaoru; Yabuki Chiori; Terasaki Tetsuya
Major involvement of low-density lipoprotein receptor-related protein 1 in the clearance of plasma free amyloid beta-peptide by the liver.
Pharmaceutical research 2006;23(7):1407-16.
2006: Takahashi Yasuko; Fuwa Haruhiko; Kaneko Akane; Sasaki Makoto; Yokoshima Satoshi; Koizumi Hifumi; Takebe Tohru; Kan Toshiyuki; Iwatsubo Takeshi; Tomita Taisuke; Natsugari Hideaki; Fukuyama Tohru
Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates.
Bioorganic & medicinal chemistry letters 2006;16(14):3813-6.
2006: Yamamoto Ryoko; Iseki Eizo; Murayama Norio; Minegishi Michiko; Marui Wami; Togo Takashi; Katsuse Omi; Kato Masanori; Iwatsubo Takeshi; Kosaka Kenji; Arai Heii
Investigation of Lewy pathology in the visual pathway of brains of dementia with Lewy bodies.
Journal of the neurological sciences 2006;246(1-2):95-101.
2006: Sato Chihiro; Iwatsubo Takeshi
Focusing on beta-amyloid: report of the 35th Annual Meeting of the Society for Neuroscience.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2006;13(2):114-6.
2006: Tian J; Shi J; Smallman R; Iwatsubo T; Mann D M A
Relationships in Alzheimer's disease between the extent of Abeta deposition in cerebral blood vessel walls, as cerebral amyloid angiopathy, and the amount of cerebrovascular smooth muscle cells and collagen.
Neuropathology and applied neurobiology 2006;32(3):332-40.
2006: Bensemain Faiza; Chapuis Julien; Tian Jinzhou; Shi Jing; Thaker Uma; Lendon Corinne; Iwatsubo Takeshi; Amouyel Philippe; Mann David; Lambert Jean-Charles
Association study of the Ubiquilin gene with Alzheimer's disease.
Neurobiology of disease 2006;22(3):691-3.
2006: Masuda Masami; Suzuki Nobuyuki; Taniguchi Sayuri; Oikawa Takayuki; Nonaka Takashi; Iwatsubo Takeshi; Hisanaga Shin-ichi; Goedert Michel; Hasegawa Masato
Small molecule inhibitors of alpha-synuclein filament assembly.
Biochemistry 2006;45(19):6085-94.
2006: Morohashi Yuichi; Kan Toshiyuki; Tominari Yusuke; Fuwa Haruhiko; Okamura Yumiko; Watanabe Naoto; Sato Chihiro; Natsugari Hideaki; Fukuyama Tohru; Iwatsubo Takeshi; Tomita Taisuke
C-terminal fragment of presenilin is the molecular target of a dipeptidic gamma-secretase-specific inhibitor DAPT (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester).
The Journal of biological chemistry 2006;281(21):14670-6.
2006: Ogura Toshihiko; Mio Kazuhiro; Hayashi Ikuo; Miyashita Hiroyuki; Fukuda Rie; Kopan Raphael; Kodama Tatsuhiko; Hamakubo Takao; Iwatsubo Takeshi; Tomita Taisuke; Sato Chikara
Three-dimensional structure of the gamma-secretase complex.
Biochemical and biophysical research communications 2006;343(2):525-34.
2006: de Silva Rohan; Lashley Tammaryn; Strand Catherine; Shiarli Anna-Maria; Shi Jing; Tian Jinzhou; Bailey Kathryn L; Davies Peter; Bigio Eileen H; Arima Kunimasa; Iseki Eizo; Murayama Shigeo; Kretzschmar Hans; Neumann Manuela; Lippa Carol; Halliday Glenda; MacKenzie James; Ravid Rivka; Dickson Dennis; Wszolek Zbigniew; Iwatsubo Takeshi; Pickering-Brown Stuart M; Holton Janice; Lees Andrew; Revesz Tamas; Mann David M A
An immunohistochemical study of cases of sporadic and inherited frontotemporal lobar degeneration using 3R- and 4R-specific tau monoclonal antibodies.
Acta neuropathologica 2006;111(4):329-40.
2006: Davidson Y; Gibbons L; Pritchard A; Hardicre J; Wren J; Tian J; Shi J; Stopford C; Julien C; Thompson J; Payton A; Thaker U; Hayes A J; Iwatsubo T; Pickering-Brown S M; Pendleton N; Horan M A; Burns A; Purandare N; Lendon C L; Neary D; Snowden J S; Mann D M A
Genetic associations between cathepsin D exon 2 C-->T polymorphism and Alzheimer's disease, and pathological correlations with genotype.
Journal of neurology, neurosurgery, and psychiatry 2006;77(4):515-7.
2006: Shi Jing; Tian Jinzhou; Pritchard Antonia; Lendon Corinne; Lambert Jean-Charles; Iwatsubo Takeshi; Mann David M A
A 3'-UTR polymorphism in the oxidized LDL receptor 1 gene increases Abeta40 load as cerebral amyloid angiopathy in Alzheimer's disease.
Acta neuropathologica 2006;111(1):15-20.
2006: Ito Genta; Ariga Hiroyoshi; Nakagawa Yasuhito; Iwatsubo Takeshi
Roles of distinct cysteine residues in S-nitrosylation and dimerization of DJ-1.
Biochemical and biophysical research communications 2006;339(2):667-72.
2006: Kuwahara Tomoki; Koyama Akihiko; Gengyo-Ando Keiko; Masuda Mayumi; Kowa Hisatomo; Tsunoda Makoto; Mitani Shohei; Iwatsubo Takeshi
Familial Parkinson mutant alpha-synuclein causes dopamine neuron dysfunction in transgenic Caenorhabditis elegans.
The Journal of biological chemistry 2006;281(1):334-40.
2006: Zhu Xiongwei; Babar Asim; Siedlak Sandra L; Yang Qiwei; Ito Genta; Iwatsubo Takeshi; Smith Mark A; Perry George; Chen Shu G
LRRK2 in Parkinson's disease and dementia with Lewy bodies.
Molecular neurodegeneration 2006;1():17.
2006: Tomita Taisuke; Tanaka Sayaka; Morohashi Yuichi; Iwatsubo Takeshi
Presenilin-dependent intramembrane cleavage of ephrin-B1.
Molecular neurodegeneration 2006;1():2.
2006: Tomita Taisuke; Iwatsubo Takeshi
gamma-secretase as a therapeutic target for treatment of Alzheimer's disease.
Current pharmaceutical design 2006;12(6):661-70.
2005: McKeith I G; Dickson D W; Lowe J; Emre M; O'Brien J T; Feldman H; Cummings J; Duda J E; Lippa C; Perry E K; Aarsland D; Arai H; Ballard C G; Boeve B; Burn D J; Costa D; Del Ser T; Dubois B; Galasko D; Gauthier S; Goetz C G; Gomez-Tortosa E; Halliday G; Hansen L A; Hardy J; Iwatsubo T; Kalaria R N; Kaufer D; Kenny R A; Korczyn A; Kosaka K; Lee V M Y; Lees A; Litvan I; Londos E; Lopez O L; Minoshima S; Mizuno Y; Molina J A; Mukaetova-Ladinska E B; Pasquier F; Perry R H; Schulz J B; Trojanowski J Q; Yamada M;
Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium.
Neurology 2005;65(12):1863-72.
2005: Watanabe Naoto; Tomita Taisuke; Sato Chihiro; Kitamura Toshio; Morohashi Yuichi; Iwatsubo Takeshi
Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1.
The Journal of biological chemistry 2005;280(51):41967-75.
2005: Takeda Toshihiro; Asahi Michio; Yamaguchi Osamu; Hikoso Shungo; Nakayama Hiroyuki; Kusakari Yoichiro; Kawai Makoto; Hongo Kenichi; Higuchi Yoshiharu; Kashiwase Kazunori; Watanabe Tetsuya; Taniike Masayuki; Nakai Atsuko; Nishida Kazuhiko; Kurihara Satoshi; Donoviel Dorit B; Bernstein Alan; Tomita Taisuke; Iwatsubo Takeshi; Hori Masatsugu; Otsu Kinya
Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(14):2069-71.
2005: Iwatsubo Takeshi; Ito Genta; Takatori Sho; Hannno Yoko; Kuwahara Tomoki
[Pathogenesis of Parkinson's disease: implications from familial Parkinson's disease]
Rinsho shinkeigaku = Clinical neurology 2005;45(11):899-901.
2005: Iwatsubo Takeshi
[Molecular pathology and therapeutic perspectives of Alzheimer's disease]
Nippon Ronen Igakkai zasshi. Japanese journal of geriatrics 2005;42(6):651-4.
2005: Shults Clifford W; Rockenstein Edward; Crews Leslie; Adame Anthony; Mante Michael; Larrea Gabriel; Hashimoto Makoto; Song David; Iwatsubo Takeshi; Tsuboi Kyoko; Masliah Eliezer
Neurological and neurodegenerative alterations in a transgenic mouse model expressing human alpha-synuclein under oligodendrocyte promoter: implications for multiple system atrophy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(46):10689-99.
2005: Lambert J-C; Mann D; Richard F; Tian J; Shi J; Thaker U; Merrot S; Harris J; Frigard B; Iwatsubo T; Lendon C; Amouyel P
Is there a relation between APOE expression and brain amyloid load in Alzheimer's disease?
Journal of neurology, neurosurgery, and psychiatry 2005;76(7):928-33.
2005: Pritchard Antonia; Harris Judith; Pritchard Colin W; St Clair David; Lemmon Helen; Lambert Jean-Charles; Chartier-Harlin Marie-Christine; Hayes Angela; Thaker Uma; Iwatsubo Takeshi; Mann David M A; Lendon Corinne
Association study and meta-analysis of low-density lipoprotein receptor related protein in Alzheimer's disease.
Neuroscience letters 2005;382(3):221-6.
2005: Smith Wanli W; Margolis Russell L; Li Xiaojie; Troncoso Juan C; Lee Michael K; Dawson Valina L; Dawson Ted M; Iwatsubo Takashi; Ross Christopher A
Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(23):5544-52.
2005: Machida Yutaka; Chiba Tomoki; Takayanagi Atsushi; Tanaka Yoshikazu; Asanuma Masato; Ogawa Norio; Koyama Akihiko; Iwatsubo Takeshi; Ito Shosuke; Jansen Poul Hening; Shimizu Nobuyoshi; Tanaka Keiji; Mizuno Yoshikuni; Hattori Nobutaka
Common anti-apoptotic roles of parkin and alpha-synuclein in human dopaminergic cells.
Biochemical and biophysical research communications 2005;332(1):233-40.
2005: Iseki Eizo; Marui Wami; Yamamoto Ryoko; Togo Takashi; Katsuse Omi; Kato Masanori; Iwatsubo Takeshi; Kosaka Kenji; Arai Heii
The nigro-striatal and nigro-amygdaloid pathways undergo different degeneration processes in brains of dementia with Lewy bodies.
Neuroscience letters 2005;380(1-2):161-5.
2005: Urano Yasuomi; Hayashi Ikuo; Isoo Noriko; Reid Patrick C; Shibasaki Yoshikazu; Noguchi Noriko; Tomita Taisuke; Iwatsubo Takeshi; Hamakubo Takao; Kodama Tatsuhiko
Association of active gamma-secretase complex with lipid rafts.
Journal of lipid research 2005;46(5):904-12.
2005: Niimura Manabu; Isoo Noriko; Takasugi Nobumasa; Tsuruoka Makiko; Ui-Tei Kumiko; Saigo Kaoru; Morohashi Yuichi; Tomita Taisuke; Iwatsubo Takeshi
Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions.
The Journal of biological chemistry 2005;280(13):12967-75.
2005: Osada Yoshihide; Hashimoto Tadafumi; Nishimura Akiko; Matsuo Yuko; Wakabayashi Tomoko; Iwatsubo Takeshi
CLAC binds to amyloid beta peptides through the positively charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils.
The Journal of biological chemistry 2005;280(9):8596-605.
2005: Taniguchi Sayuri; Suzuki Nobuyuki; Masuda Masami; Hisanaga Shin-ichi; Iwatsubo Takeshi; Goedert Michel; Hasegawa Masato
Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins.
The Journal of biological chemistry 2005;280(9):7614-23.
2005: Nonaka Takashi; Iwatsubo Takeshi; Hasegawa Masato
Ubiquitination of alpha-synuclein.
Biochemistry 2005;44(1):361-8.
2004: Lo Bianco Christophe; Schneider Bernard L; Bauer Matthias; Sajadi Ali; Brice Alexis; Iwatsubo Takeshi; Aebischer Patrick
Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(50):17510-5.
2004: Iwatsubo Takeshi
[Pathogenesis of Alzheimer's disease: implications from amyloid research front]
Rinsho shinkeigaku = Clinical neurology 2004;44(11):768-70.
2004: Kowa Hisatomo; Iwatsubo Takeshi
[Amyloid beta peptide]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 11():307-9.
2004: Yamada Masanori; Iwatsubo Takeshi; Mizuno Yoshikuni; Mochizuki Hideki
Overexpression of alpha-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of alpha-synuclein and activation of caspase-9: resemblance to pathogenetic changes in Parkinson's disease.
Journal of neurochemistry 2004;91(2):451-61.
2004: Nonaka Takashi; Iwatsubo Takeshi; Hasegawa Masato
[Analysis of alpha-synuclein and its significance]
Nippon rinsho. Japanese journal of clinical medicine 2004;62(9):1623-8.
2004: Hayashi Ikuo; Urano Yasuomi; Fukuda Rie; Isoo Noriko; Kodama Tatsuhiko; Hamakubo Takao; Tomita Taisuke; Iwatsubo Takeshi
Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles.
The Journal of biological chemistry 2004;279(36):38040-6.
2004: Hirai Yu; Fujita Shinobu C; Iwatsubo Takeshi; Hasegawa Masato
Phosphorylated alpha-synuclein in normal mouse brain.
FEBS letters 2004;572(1-3):227-32.
2004: Tomita Taisuke; Iwatsubo Takeshi
[Recent advances in Alzheimer's disease-related gamma-secretase complex]
Seikagaku. The Journal of Japanese Biochemical Society 2004;76(7):666-70.
2004: Kowa Hisatomo; Sakakura Tomoko; Matsuura Yusuke; Wakabayashi Tomoko; Mann David M A; Duff Karen; Tsuji Shoji; Hashimoto Tadafumi; Iwatsubo Takeshi
Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits.
The American journal of pathology 2004;165(1):273-81.
2004: Wakutani Y; Watanabe K; Adachi Y; Wada-Isoe K; Urakami K; Ninomiya H; Saido T C; Hashimoto T; Iwatsubo T; Nakashima K
Novel amyloid precursor protein gene missense mutation (D678N) in probable familial Alzheimer's disease.
Journal of neurology, neurosurgery, and psychiatry 2004;75(7):1039-42.
2004: Tomita Taisuke; Iwatsubo Takeshi
The inhibition of gamma-secretase as a therapeutic approach to Alzheimer's disease.
Drug news & perspectives 2004;17(5):321-5.
2004: Nagano Osamu; Murakami Daizo; Hartmann Dieter; De Strooper Bart; Saftig Paul; Iwatsubo Takeshi; Nakajima Motowo; Shinohara Masanori; Saya Hideyuki
Cell-matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca(2+) influx and PKC activation.
The Journal of cell biology 2004;165(6):893-902.
2004: Iwatsubo Takeshi
The gamma-secretase complex: machinery for intramembrane proteolysis.
Current opinion in neurobiology 2004;14(3):379-83.
2004: Zhang Yong; Hayes Angela; Pritchard Antonia; Thaker Uma; Haque M Sayeed; Lemmon Helen; Harris Judith; Cumming Alistair; Lambert Jean-Charles; Chartier-Harlin Marie-Christine; St Clair David; Iwatsubo Takeshi; Mann David M; Lendon Corinne L
Interleukin-6 promoter polymorphism: risk and pathology of Alzheimer's disease.
Neuroscience letters 2004;362(2):99-102.
2004: Iwatsubo Takeshi
[Alzheimer's disease: focus on beta-amyloid and gamma-secretase]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2004;49(7 Suppl):1086-90.
2004: Kawasumi Masaoki; Chiba Tomohiro; Yamada Marina; Miyamae-Kaneko Makiko; Matsuoka Masaaki; Nakahara Jin; Tomita Taisuke; Iwatsubo Takeshi; Kato Shigeaki; Aiso Sadakazu; Nishimoto Ikuo; Kouyama Keisuke
Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer's disease in aged mice.
The European journal of neuroscience 2004;19(10):2826-38.
2004: Umeda Yuri; Taniguchi Sayuri; Arima Kunimasa; Piao Yue-Shan; Takahashi Hitoshi; Iwatsubo Takeshi; Mann David; Hasegawa Masato
Alterations in human tau transcripts correlate with those of neurofilament in sporadic tauopathies.
Neuroscience letters 2004;359(3):151-4.
2004: Kan Toshiyuki; Tominari Yusuke; Rikimaru Kentaro; Morohashi Yuichi; Natsugari Hideaki; Tomita Taisuke; Iwatsubo Takeshi; Fukuyama Tohru
Parallel synthesis of DAPT derivatives and their gamma-secretase-inhibitory activity.
Bioorganic & medicinal chemistry letters 2004;14(8):1983-5.
2004: Nishie Makoto; Mori Fumiaki; Fujiwara Hideo; Hasegawa Masato; Yoshimoto Makoto; Iwatsubo Takeshi; Takahashi Hitoshi; Wakabayashi Koichi
Accumulation of phosphorylated alpha-synuclein in the brain and peripheral ganglia of patients with multiple system atrophy.
Acta neuropathologica 2004;107(4):292-8.
2004: Matsubayashi Hiroko; Sese Sonoka; Lee Jong-Seo; Shirakawa Tadaoki; Iwatsubo Takeshi; Tomita Taisuke; Yanagawa Shin-ichi
Biochemical characterization of the Drosophila wingless signaling pathway based on RNA interference.
Molecular and cellular biology 2004;24(5):2012-24.
2004: Lambert J-C; Mann D; Harris J; Araria-Goumidi L; Chartier-Harlin M-C; Cottel D; Iwatsubo T; Amouyel P; Lendon C
Association study of Notch 4 polymorphisms with Alzheimer's disease.
Journal of neurology, neurosurgery, and psychiatry 2004;75(3):377-81.
2004: Taniguchi S; McDonagh A M; Pickering-Brown S M; Umeda Y; Iwatsubo T; Hasegawa M; Mann D M A
The neuropathology of frontotemporal lobar degeneration with respect to the cytological and biochemical characteristics of tau protein.
Neuropathology and applied neurobiology 2004;30(1):1-18.
2004: Tanaka Mikiei; Kim Yong Man; Lee Gwang; Junn Eunsung; Iwatsubo Takeshi; Mouradian M Maral
Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective.
The Journal of biological chemistry 2004;279(6):4625-31.
2004: Iwatsubo Takeshi
Assembly and activation of the gamma-secretase complex: roles of presenilin cofactors.
Molecular psychiatry 2004;9(1):8-10.
2004: Busby Victoria; Goossens Steven; Nowotny Petra; Hamilton Gillian; Smemo Scott; Harold Denise; Turic Dragana; Jehu Luke; Myers Amanda; Womick Meredith; Woo Daniel; Compton Danielle; Doil Lisa M; Tacey Kristina M; Lau Kit F; Al-Saraj Safa; Killick Richard; Pickering-Brown Stuart; Moore Pamela; Hollingworth Paul; Archer Nicola; Foy Catherine; Walter Sarah; Lendon Corrine; Iwatsubo Takeshi; Morris John C; Norton Joanne; Mann David; Janssens Barbara; Hardy John; O'Donovan Michael; Jones Lesley; Williams Julie; Holmans Peter; Owen Michael J; Grupe Andrew; Powell John; van Hengel Jolanda; Goate Alison; Van Roy Frans; Lovestone Simon
Alpha-T-catenin is expressed in human brain and interacts with the Wnt signaling pathway but is not responsible for linkage to chromosome 10 in Alzheimer's disease.
Neuromolecular medicine 2004;5(2):133-46.
2003: Söderberg Linda; Zhukareva Victoria; Bogdanovic Nenad; Hashimoto Tadafumi; Winblad Bengt; Iwatsubo Takeshi; Lee Virginia M Y; Trojanowski John Q; Näslund Jan
Molecular identification of AMY, an Alzheimer disease amyloid-associated protein.
Journal of neuropathology and experimental neurology 2003;62(11):1108-17.
2003: Iwatsubo Takeshi
Aggregation of alpha-synuclein in the pathogenesis of Parkinson's disease.
Journal of neurology 2003;250 Suppl 3():III11-4.
2003: Schroeter Eric H; Ilagan Ma Xenia G; Brunkan Anne L; Hecimovic Silva; Li Yue-ming; Xu Min; Lewis Huw D; Saxena Meera T; De Strooper Bart; Coonrod Archie; Tomita Taisuke; Iwatsubo Takeshi; Moore Chad L; Goate Alison; Wolfe Michael S; Shearman Mark; Kopan Raphael
A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(22):13075-80.
2003: Abe Yoichiro; Kouyama Keisuke; Tomita Taisuke; Tomita Yusuke; Ban Norimitsu; Nawa Mikiro; Matsuoka Masaaki; Niikura Takako; Aiso Sadakazu; Kita Yoshiko; Iwatsubo Takeshi; Nishimoto Ikuo
Analysis of neurons created from wild-type and Alzheimer's mutation knock-in embryonic stem cells by a highly efficient differentiation protocol.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(24):8513-25.
2003: Kan Toshiyuki; Tominari Yusuke; Morohashi Yuichi; Natsugari Hideaki; Tomita Taisuke; Iwatsubo Takeshi; Fukuyama Tohru
Solid-phase synthesis of photoaffinity probes: highly efficient incorporation of biotin-tag and cross-linking groups.
Chemical communications (Cambridge, England) 2003;(17):2244-5.
2003: Mori Fumiaki; Piao Yue-Shan; Hayashi Shintaro; Fujiwara Hideo; Hasegawa Masato; Yoshimoto Makoto; Iwatsubo Takeshi; Takahashi Hitoshi; Wakabayashi Koichi
Alpha-synuclein accumulates in Purkinje cells in Lewy body disease but not in multiple system atrophy.
Journal of neuropathology and experimental neurology 2003;62(8):812-9.
2003: Saito Yuko; Kawashima Akiko; Ruberu Nyoka N; Fujiwara Hideo; Koyama Shunichi; Sawabe Motoji; Arai Tomio; Nagura Hiroshi; Yamanouchi Hiroshi; Hasegawa Masato; Iwatsubo Takeshi; Murayama Shigeo
Accumulation of phosphorylated alpha-synuclein in aging human brain.
Journal of neuropathology and experimental neurology 2003;62(6):644-54.
2003: Lambert J-C; Luedecking-Zimmer E; Merrot S; Hayes A; Thaker U; Desai P; Houzet A; Hermant X; Cottel D; Pritchard A; Iwatsubo T; Pasquier F; Frigard B; Conneally P M; Chartier-Harlin M-C; DeKosky S T; Lendon C; Mann D; Kamboh M I; Amouyel P
Association of 3'-UTR polymorphisms of the oxidised LDL receptor 1 (OLR1) gene with Alzheimer's disease.
Journal of medical genetics 2003;40(6):424-30.
2003: Takahashi Yasuko; Hayashi Ikuo; Tominari Yusuke; Rikimaru Kentaro; Morohashi Yuichi; Kan Toshiyuki; Natsugari Hideaki; Fukuyama Tohru; Tomita Taisuke; Iwatsubo Takeshi
Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation.
The Journal of biological chemistry 2003;278(20):18664-70.
2003: Iwatsubo Takeshi
Molecular pathogenesis of Alzheimer's disease.
Internal medicine (Tokyo, Japan) 2003;42(3):312.
2003: Kamenetz Flavio; Tomita Taisuke; Hsieh Helen; Seabrook Guy; Borchelt David; Iwatsubo Takeshi; Sisodia Sangram; Malinow Roberto
APP processing and synaptic function.
Neuron 2003;37(6):925-37.
2003: Takasugi Nobumasa; Tomita Taisuke; Hayashi Ikuo; Tsuruoka Makiko; Niimura Manabu; Takahashi Yasuko; Thinakaran Gopal; Iwatsubo Takeshi
The role of presenilin cofactors in the gamma-secretase complex.
Nature 2003;422(6930):438-41.
2003: Murakami Daizo; Okamoto Isamu; Nagano Osamu; Kawano Yoshiaki; Tomita Taisuke; Iwatsubo Takeshi; De Strooper Bart; Yumoto Eiji; Saya Hideyuki
Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44.
Oncogene 2003;22(10):1511-6.
2003: Thaker U; McDonagh A M; Iwatsubo T; Lendon C L; Pickering-Brown S M; Mann D M A
Tau load is associated with apolipoprotein E genotype and the amount of amyloid beta protein, Abeta40, in sporadic and familial Alzheimer's disease.
Neuropathology and applied neurobiology 2003;29(1):35-44.
2003: Takahashi Makio; Kanuka Hirotaka; Fujiwara Hideo; Koyama Akihiko; Hasegawa Masato; Miura Masayuki; Iwatsubo Takeshi
Phosphorylation of alpha-synuclein characteristic of synucleinopathy lesions is recapitulated in alpha-synuclein transgenic Drosophila.
Neuroscience letters 2003;336(3):155-8.
2002: Takasugi Nobumasa; Takahashi Yasuko; Morohashi Yuichi; Tomita Taisuke; Iwatsubo Takeshi
The mechanism of gamma-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals.
The Journal of biological chemistry 2002;277(51):50198-205.
2002: Hasegawa Masato; Fujiwara Hideo; Nonaka Takashi; Wakabayashi Koichi; Takahashi Hitoshi; Lee Virginia M-Y; Trojanowski John Q; Mann David; Iwatsubo Takeshi
Phosphorylated alpha-synuclein is ubiquitinated in alpha-synucleinopathy lesions.
The Journal of biological chemistry 2002;277(50):49071-6.
2002: Iwatsubo Takeshi
[The mechanism of A beta production and its inhibition as a therapeutic strategy for the prevention of Alzheimer's disease]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 2002;120(1):30P-33P.
2002: Neumann Manuela; Kahle Philipp J; Giasson Benoit I; Ozmen Laurence; Borroni Edilio; Spooren Will; Müller Veronika; Odoy Sabine; Fujiwara Hideo; Hasegawa Masato; Iwatsubo Takeshi; Trojanowski John Q; Kretzschmar Hans A; Haass Christian
Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies.
The Journal of clinical investigation 2002;110(10):1429-39.
2002: Matsushita Sachio; Arai Hiroyuki; Okamura Nobuyuki; Ohmori Tomohiro; Takasugi Keiichi; Matsui Toshifumi; Maruyama Masahiro; Iwatsubo Takeshi; Higuchi Susumu
Clinical and biomarker investigation of a patient with a novel presenilin-1 mutation (A431V) in the mild cognitive impairment stage of Alzheimer's disease.
Biological psychiatry 2002;52(9):907-10.
2002: Leem Jae Yoon; Saura Carlos A; Pietrzik Claus; Christianson John; Wanamaker Christian; King LaShaunda T; Veselits Margaret L; Tomita Taisuke; Gasparini Laura; Iwatsubo Takeshi; Xu Huaxi; Green William N; Koo Edward H; Thinakaran Gopal
A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface.
Neurobiology of disease 2002;11(1):64-82.
2002: Hayes A; Thaker U; Iwatsubo T; Pickering-Brown S M; Mann D M A
Pathological relationships between microglial cell activity and tau and amyloid beta protein in patients with Alzheimer's disease.
Neuroscience letters 2002;331(3):171-4.
2002: Watanabe Tomomi; Nakagawa Kentaro; Ohata Shinya; Kitagawa Daiju; Nishitai Gen; Seo Jungwon; Tanemura Shuhei; Shimizu Nao; Kishimoto Hiroyuki; Wada Teiji; Aoki Junken; Arai Hiroyuki; Iwatsubo Takeshi; Mochita Miyuki; Watanabe Toshio; Satake Masanobu; Ito Yoshiaki; Matsuyama Toshifumi; Mak Tak W; Penninger Josef M; Nishina Hiroshi; Katada Toshiaki
SEK1/MKK4-mediated SAPK/JNK signaling participates in embryonic hepatoblast proliferation via a pathway different from NF-kappaB-induced anti-apoptosis.
Developmental biology 2002;250(2):332-47.
2002: Okochi Masayasu; Steiner Harald; Fukumori Akio; Tanii Hisashi; Tomita Taisuke; Tanaka Toshihisa; Iwatsubo Takeshi; Kudo Takashi; Takeda Masatoshi; Haass Christian
Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.
The EMBO journal 2002;21(20):5408-16.
2002: Iwatsubo Takeshi
[Molecular mechanism of Alzheimer disease]
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2002;91 Suppl():149-51.
2002: Ohara Shinji; Tsuyuzaki Jun; Oide Takashi; Arai Hiroyuki; Higuchi Susumu; Hasegawa Masato; Iwatsubo Takeshi
A clinical and neuropathological study of an unusual case of sporadic tauopathy. A variant of corticobasal degeneration?
Neuroscience letters 2002;330(1):84-8.
2002: Lendon C L; Thaker U; Harris J M; McDonagh A M; Lambert J-C; Chartier-Harlin M-C; Iwatsubo T; Pickering-Brown S M; Mann D M A
The angiotensin 1-converting enzyme insertion (I)/deletion (D) polymorphism does not influence the extent of amyloid or tau pathology in patients with sporadic Alzheimer's disease.
Neuroscience letters 2002;328(3):314-8.
2002: Araria-Goumidi L; Lambert J C; Mann D M A; Lendon C; Frigard B; Iwatsubo T; Cottel D; Amouyel P; Chartier-Harlin M C
Association study of three polymorphisms of TGF-beta1 gene with Alzheimer's disease.
Journal of neurology, neurosurgery, and psychiatry 2002;73(1):62-4.
2002: Iwatsubo Takeshi
[alpha-synuclein and Parkinson's disease]
Seikagaku. The Journal of Japanese Biochemical Society 2002;74(6):477-82.
2002: Hazeki Noriko; Tsukamoto Tadashi; Yazawa Ikuru; Koyama Minami; Hattori Shunji; Someki Iori; Iwatsubo Takeshi; Nakamura Koichiro; Goto Jun; Kanazawa Ichiro
Ultrastructure of nuclear aggregates formed by expressing an expanded polyglutamine.
Biochemical and biophysical research communications 2002;294(2):429-40.
2002: Tomita Taisuke; Katayama Ryohei; Takikawa Rie; Iwatsubo Takeshi
Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments.
FEBS letters 2002;520(1-3):117-21.
2002: Kahle Philipp J; Neumann Manuela; Ozmen Laurence; Muller Veronika; Jacobsen Helmut; Spooren Will; Fuss Babette; Mallon Barbara; Macklin Wendy B; Fujiwara Hideo; Hasegawa Masato; Iwatsubo Takeshi; Kretzschmar Hans A; Haass Christian
Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes.
EMBO reports 2002;3(6):583-8.
2002: Green E K; Harris J M; Lemmon H; Lambert J C; Chartier-Harlin M C; St Clair D; Mann D M A; Iwatsubo T; Lendon C L
Are interleukin-1 gene polymorphisms risk factors or disease modifiers in AD?
Neurology 2002;58(10):1566-8.
2002: Green E K; Thaker U; McDonagh A M; Iwatsubo T; Lambert J-C; Chartier-Harlin M-C; Harris J M; Pickering-Brown S M; Lendon C L; Mann D M A
A polymorphism within intron 11 of the tau gene is not increased in frequency in patients with sporadic Alzheimer's disease, nor does it influence the extent of tau pathology in the brain.
Neuroscience letters 2002;324(2):113-6.
2002: Miake Hirotomo; Mizusawa Hidehiro; Iwatsubo Takeshi; Hasegawa Masato
Biochemical characterization of the core structure of alpha-synuclein filaments.
The Journal of biological chemistry 2002;277(21):19213-9.
2002: Hashimoto Tadafumi; Wakabayashi Tomoko; Watanabe Atsushi; Kowa Hisatomo; Hosoda Ritsuko; Nakamura Atsushi; Kanazawa Ichiro; Arai Takao; Takio Koji; Mann David M A; Iwatsubo Takeshi
CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV.
The EMBO journal 2002;21(7):1524-34.
2002: Hayashi Shintaro; Toyoshima Yasuko; Hasegawa Masato; Umeda Yuri; Wakabayashi Koichi; Tokiguchi Susumu; Iwatsubo Takeshi; Takahashi Hitoshi
Late-onset frontotemporal dementia with a novel exon 1 (Arg5His) tau gene mutation.
Annals of neurology 2002;51(4):525-30.
2002: Morohashi Yuichi; Hatano Noriyuki; Ohya Susumu; Takikawa Rie; Watabiki Tomonari; Takasugi Nobumasa; Imaizumi Yuji; Tomita Taisuke; Iwatsubo Takeshi
Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4.
The Journal of biological chemistry 2002;277(17):14965-75.
2002: Fujiwara Hideo; Hasegawa Masato; Dohmae Naoshi; Kawashima Akiko; Masliah Eliezer; Goldberg Matthew S; Shen Jie; Takio Koji; Iwatsubo Takeshi
alpha-Synuclein is phosphorylated in synucleinopathy lesions.
Nature cell biology 2002;4(2):160-4.
2001: Iwatsubo T
[Beta-amyloid protein: recent progress in basic research and therapeutic approaches]
Rinsho shinkeigaku = Clinical neurology 2001;41(12):1198-200.
2001: Kahle P J; Neumann M; Ozmen L; Müller V; Odoy S; Okamoto N; Jacobsen H; Iwatsubo T; Trojanowski J Q; Takahashi H; Wakabayashi K; Bogdanovic N; Riederer P; Kretzschmar H A; Haass C
Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model.
The American journal of pathology 2001;159(6):2215-25.
2001: Ikegaya Y; Kim J A; Baba M; Iwatsubo T; Nishiyama N; Matsuki N
Rapid and reversible changes in dendrite morphology and synaptic efficacy following NMDA receptor activation: implication for a cellular defense against excitotoxicity.
Journal of cell science 2001;114(Pt 22):4083-93.
2001: Mori H; Motoi Y; Kobayashi T; Hasegawa M; Yamamura A; Iwatsubo T; Mizuno Y
Tau accumulation in a patient with pallidonigroluysian atrophy.
Neuroscience letters 2001;309(2):89-92.
2001: Tomita T; Watabiki T; Takikawa R; Morohashi Y; Takasugi N; Kopan R; De Strooper B; Iwatsubo T
The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins.
The Journal of biological chemistry 2001;276(35):33273-81.
2001: Mann D M; Takeuchi A; Sato S; Cairns N J; Lantos P L; Rossor M N; Haltia M; Kalimo H; Iwatsubo T
Cases of Alzheimer's disease due to deletion of exon 9 of the presenilin-1 gene show an unusual but characteristic beta-amyloid pathology known as 'cotton wool' plaques.
Neuropathology and applied neurobiology 2001;27(3):189-96.
2001: Mann D M; Pickering-Brown S M; Takeuchi A; Iwatsubo T;
Amyloid angiopathy and variability in amyloid beta deposition is determined by mutation position in presenilin-1-linked Alzheimer's disease.
The American journal of pathology 2001;158(6):2165-75.
2001: Lambert J C; Mann D M; Harris J M; Chartier-Harlin M C; Cumming A; Coates J; Lemmon H; StClair D; Iwatsubo T; Lendon C
The -48 C/T polymorphism in the presenilin 1 promoter is associated with an increased risk of developing Alzheimer's disease and an increased Abeta load in brain.
Journal of medical genetics 2001;38(6):353-5.
2001: Iwata H; Tomita T; Maruyama K; Iwatsubo T
Subcellular compartment and molecular subdomain of beta-amyloid precursor protein relevant to the Abeta 42-promoting effects of Alzheimer mutant presenilin 2.
The Journal of biological chemistry 2001;276(24):21678-85.
2001: Shirotani K; Tsubuki S; Iwata N; Takaki Y; Harigaya W; Maruyama K; Kiryu-Seo S; Kiyama H; Iwata H; Tomita T; Iwatsubo T; Saido T C
Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases.
The Journal of biological chemistry 2001;276(24):21895-901.
2001: Verkkoniemi A; Kalimo H; Paetau A; Somer M; Iwatsubo T; Hardy J; Haltia M
Variant Alzheimer disease with spastic paraparesis: neuropathological phenotype.
Journal of neuropathology and experimental neurology 2001;60(5):483-92.
2001: Mann D M; McDonagh A M; Pickering-Brown S M; Kowa H; Iwatsubo T
Amyloid beta protein deposition in patients with frontotemporal lobar degeneration: relationship to age and apolipoprotein E genotype.
Neuroscience letters 2001;304(3):161-4.
2001: Kuzuhara S; Kokubo Y; Sasaki R; Narita Y; Yabana T; Hasegawa M; Iwatsubo T
Familial amyotrophic lateral sclerosis and parkinsonism-dementia complex of the Kii Peninsula of Japan: clinical and neuropathological study and tau analysis.
Annals of neurology 2001;49(4):501-11.
2001: Hirota N; Ito K; Iwatsubo T; Green C E; Tyson C A; Shimada N; Suzuki H; Sugiyama Y
In vitro/in vivo scaling of alprazolam metabolism by CYP3A4 and CYP3A5 in humans.
Biopharmaceutics & drug disposition 2001;22(2):53-71.
2001: Piao Y S; Hayashi S; Hasegawa M; Wakabayashi K; Yamada M; Yoshimoto M; Ishikawa A; Iwatsubo T; Takahashi H
Co-localization of alpha-synuclein and phosphorylated tau in neuronal and glial cytoplasmic inclusions in a patient with multiple system atrophy of long duration.
Acta neuropathologica 2001;101(3):285-93.
2001: Ohya S; Morohashi Y; Muraki K; Tomita T; Watanabe M; Iwatsubo T; Imaizumi Y
Molecular cloning and expression of the novel splice variants of K(+) channel-interacting protein 2.
Biochemical and biophysical research communications 2001;282(1):96-102.
2001: Lambert J C; Mann D; Goumidi L; Harris J; Amouyel P; Iwatsubo T; Lendon C; Chartier-Harlin M C
Effect of the APOE promoter polymorphisms on cerebral amyloid peptide deposition in Alzheimer's disease.
Lancet 2001;357(9256):608-9.
2001: Lee J A; Long Z; Nimura N; Iwatsubo T; Imai K; Homma H
Localization, transport, and uptake of D-aspartate in the rat adrenal and pituitary glands.
Archives of biochemistry and biophysics 2001;385(2):242-9.
2001: Taniguchi S; Fujita Y; Hayashi S; Kakita A; Takahashi H; Murayama S; Saido T C; Hisanaga S; Iwatsubo T; Hasegawa M
Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains.
FEBS letters 2001;489(1):46-50.
2000: Iwatsubo T
[beta-amyloid cascade: current status and future directions]
Rinsho shinkeigaku = Clinical neurology 2000;40(12):1228-30.
2000: Pickering-Brown S; Baker M; Yen S H; Liu W K; Hasegawa M; Cairns N; Lantos P L; Rossor M; Iwatsubo T; Davies Y; Allsop D; Furlong R; Owen F; Hardy J; Mann D; Hutton M
Pick's disease is associated with mutations in the tau gene.
Annals of neurology 2000;48(6):859-67.
2000: Takahashi M; Doré S; Ferris C D; Tomita T; Sawa A; Wolosker H; Borchelt D R; Iwatsubo T; Kim S H; Thinakaran G; Sisodia S S; Snyder S H
Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimer's disease.
Neuron 2000;28(2):461-73.
2000: Lambert J C; Mann D; Goumidi L; Harris J; Pasquier F; Frigard B; Cottel D; Lendon C; Iwatsubo T; Amouyel P; Chartier-Harlin M C
A FE65 polymorphism associated with risk of developing sporadic late-onset alzheimer's disease but not with Abeta loading in brains.
Neuroscience letters 2000;293(1):29-32.
2000: Wakabayashi K; Shibasaki Y; Hasegawa M; Horikawa Y; Soma Y; Hayashi S; Morita T; Iwatsubo T; Takahashi H
Primary progressive aphasia with focal glial tauopathy.
Neuropathology and applied neurobiology 2000;26(5):477-81.
2000: Yamazaki M; Arai Y; Baba M; Iwatsubo T; Mori O; Katayama Y; Oyanagi K
Alpha-synuclein inclusions in amygdala in the brains of patients with the parkinsonism-dementia complex of Guam.
Journal of neuropathology and experimental neurology 2000;59(7):585-91.
2000: Takeuchi A; Irizarry M C; Duff K; Saido T C; Hsiao Ashe K; Hasegawa M; Mann D M; Hyman B T; Iwatsubo T
Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss.
The American journal of pathology 2000;157(1):331-9.
2000: Saura C A; Tomita T; Soriano S; Takahashi M; Leem J Y; Honda T; Koo E H; Iwatsubo T; Thinakaran G
The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced abeta 42 production mediated by familial early onset Alzheimer's disease-linked PS variants.
The Journal of biological chemistry 2000;275(22):17136-42.
2000: Arima K; Kowalska A; Hasegawa M; Mukoyama M; Watanabe R; Kawai M; Takahashi K; Iwatsubo T; Tabira T; Sunohara N
Two brothers with frontotemporal dementia and parkinsonism with an N279K mutation of the tau gene.
Neurology 2000;54(9):1787-95.
2000: Yasuda M; Takamatsu J; D'Souza I; Crowther R A; Kawamata T; Hasegawa M; Hasegawa H; Spillantini M G; Tanimukai S; Poorkaj P; Varani L; Varani G; Iwatsubo T; Goedert M; Schellenberg D G; Tanaka C
A novel mutation at position +12 in the intron following exon 10 of the tau gene in familial frontotemporal dementia (FTD-Kumamoto)
Annals of neurology 2000;47(4):422-9.
2000: Nishizawa T; Nagao T; Iwatsubo T; Forte J G; Urushidani T
Molecular cloning and characterization of a novel chloride intracellular channel-related protein, parchorin, expressed in water-secreting cells.
The Journal of biological chemistry 2000;275(15):11164-73.
2000: Iwatsubo T
[Alzheimer's disease: basic aspects]
Nippon Ronen Igakkai zasshi. Japanese journal of geriatrics 2000;37(3):207-11.
2000: Wakabayashi K; Fukushima T; Koide R; Horikawa Y; Hasegawa M; Watanabe Y; Noda T; Eguchi I; Morita T; Yoshimoto M; Iwatsubo T; Takahashi H
Juvenile-onset generalized neuroaxonal dystrophy (Hallervorden-Spatz disease) with diffuse neurofibrillary and lewy body pathology.
Acta neuropathologica 2000;99(3):331-6.
2000: Okochi M; Walter J; Koyama A; Nakajo S; Baba M; Iwatsubo T; Meijer L; Kahle P J; Haass C
Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein.
The Journal of biological chemistry 2000;275(1):390-7.
1999: Iwatsubo T
[Parkinson's disease, dementia with Lewy bodies, multiple system atrophy and alpha-synuclein]
Rinsho shinkeigaku = Clinical neurology 1999;39(12):1285-6.
1999: Tomita T; Iwatsubo T
[Molecular cell biology of presenilins]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 1999;114(6):337-46.
1999: Tomita T; Takikawa R; Koyama A; Morohashi Y; Takasugi N; Saido T C; Maruyama K; Iwatsubo T
C terminus of presenilin is required for overproduction of amyloidogenic Abeta42 through stabilization and endoproteolysis of presenilin.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(24):10627-34.
1999: Okamura N; Arai H; Higuchi M; Tashiro M; Matsui T; Itoh M; Iwatsubo T; Tomita T; Sasaki H
Cerebrospinal fluid levels of amyloid beta-peptide1-42, but not tau have positive correlation with brain glucose metabolism in humans.
Neuroscience letters 1999;273(3):203-7.
1999: Fukumoto H; Tomita T; Matsunaga H; Ishibashi Y; Saido T C; Iwatsubo T
Primary cultures of neuronal and non-neuronal rat brain cells secrete similar proportions of amyloid beta peptides ending at A beta40 and A beta42.
Neuroreport 1999;10(14):2965-9.
1999: McGowan E; Sanders S; Iwatsubo T; Takeuchi A; Saido T; Zehr C; Yu X; Uljon S; Wang R; Mann D; Dickson D; Duff K
Amyloid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes.
Neurobiology of disease 1999;6(4):231-44.
1999: Lee J A; Homma H; Tashiro K; Iwatsubo T; Imai K
D-aspartate localization in the rat pituitary gland and retina.
Brain research 1999;838(1-2):193-9.
1999: Nishiyama K; Trapp B D; Ikezu T; Ransohoff R M; Tomita T; Iwatsubo T; Kanazawa I; Hsiao K K; Lisanti M P; Okamoto T
Caveolin-3 upregulation activates beta-secretase-mediated cleavage of the amyloid precursor protein in Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(15):6538-48.
1999: Iwatsubo T
[alpha-Synuclein and familial Parkinson's disease]
No to shinkei = Brain and nerve 1999;51(6):481-6.
1999: Saura C A; Tomita T; Davenport F; Harris C L; Iwatsubo T; Thinakaran G
Evidence that intramolecular associations between presenilin domains are obligatory for endoproteolytic processing.
The Journal of biological chemistry 1999;274(20):13818-23.
1999: Murayama O; Tomita T; Nihonmatsu N; Murayama M; Sun X; Honda T; Iwatsubo T; Takashima A
Enhancement of amyloid beta 42 secretion by 28 different presenilin 1 mutations of familial Alzheimer's disease.
Neuroscience letters 1999;265(1):61-3.
1999: Iwatsubo T; Suzuki H; Sugiyama Y
Determination of the rate-limiting step in the hepatic elimination of YM796 by isolated rat hepatocytes.
Pharmaceutical research 1999;16(1):110-6.
1999: Galvin J E; Lee V M; Schmidt M L; Tu P H; Iwatsubo T; Trojanowski J Q
Pathobiology of the Lewy body.
Advances in neurology 1999;80():313-24.
1998: Iseki E; Marui W; Kosaka K; Akiyama H; Ueda K; Iwatsubo T
Degenerative terminals of the perforant pathway are human alpha-synuclein-immunoreactive in the hippocampus of patients with diffuse Lewy body disease.
Neuroscience letters 1998;258(2):81-4.
1998: Naruse S; Thinakaran G; Luo J J; Kusiak J W; Tomita T; Iwatsubo T; Qian X; Ginty D D; Price D L; Borchelt D R; Wong P C; Sisodia S S
Effects of PS1 deficiency on membrane protein trafficking in neurons.
Neuron 1998;21(5):1213-21.
1998: Hosomi A; Goto K; Kondo H; Iwatsubo T; Yokota T; Ogawa M; Arita M; Aoki J; Arai H; Inoue K
Localization of alpha-tocopherol transfer protein in rat brain.
Neuroscience letters 1998;256(3):159-62.
1998: Hosoda R; Saido T C; Otvos L; Arai T; Mann D M; Lee V M; Trojanowski J Q; Iwatsubo T
Quantification of modified amyloid beta peptides in Alzheimer disease and Down syndrome brains.
Journal of neuropathology and experimental neurology 1998;57(11):1089-95.
1998: Lippa C F; Fujiwara H; Mann D M; Giasson B; Baba M; Schmidt M L; Nee L E; O'Connell B; Pollen D A; St George-Hyslop P; Ghetti B; Nochlin D; Bird T D; Cairns N J; Lee V M; Iwatsubo T; Trojanowski J Q
Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes.
The American journal of pathology 1998;153(5):1365-70.
1998: Trojanowski J Q; Goedert M; Iwatsubo T; Lee V M
Fatal attractions: abnormal protein aggregation and neuron death in Parkinson's disease and Lewy body dementia.
Cell death and differentiation 1998;5(10):832-7.
1998: Sakai K; Homma H; Lee J A; Fukushima T; Santa T; Tashiro K; Iwatsubo T; Imai K
Emergence of D-aspartic acid in the differentiating neurons of the rat central nervous system.
Brain research 1998;808(1):65-71.
1998: Iwatsubo T; Tomita T
[Genetic factors in the pathogenesis of Alzheimer's disease: roles of beta-amyloid and presenilins]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1998;43(13):1963-72.
1998: Ito K; Iwatsubo T; Kanamitsu S; Ueda K; Suzuki H; Sugiyama Y
Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver.
Pharmacological reviews 1998;50(3):387-412.
1998: Tu P H; Galvin J E; Baba M; Giasson B; Tomita T; Leight S; Nakajo S; Iwatsubo T; Trojanowski J Q; Lee V M
Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein.
Annals of neurology 1998;44(3):415-22.
1998: Long Z; Homma H; Lee J A; Fukushima T; Santa T; Iwatsubo T; Yamada R; Imai K
Biosynthesis of D-aspartate in mammalian cells.
FEBS letters 1998;434(3):231-5.
1998: Tomita T; Tokuhiro S; Hashimoto T; Aiba K; Saido T C; Maruyama K; Iwatsubo T
Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.
The Journal of biological chemistry 1998;273(33):21153-60.
1998: Takigawa Y; Homma H; Lee J A; Fukushima T; Santa T; Iwatsubo T; Imai K
D-aspartate uptake into cultured rat pinealocytes and the concomitant effect on L-aspartate levels and melatonin secretion.
Biochemical and biophysical research communications 1998;248(3):641-7.
1998: Kanai M; Matsubara E; Isoe K; Urakami K; Nakashima K; Arai H; Sasaki H; Abe K; Iwatsubo T; Kosaka T; Watanabe M; Tomidokoro Y; Shizuka M; Mizushima K; Nakamura T; Igeta Y; Ikeda Y; Amari M; Kawarabayashi T; Ishiguro K; Harigaya Y; Wakabayashi K; Okamoto K; Hirai S; Shoji M
Longitudinal study of cerebrospinal fluid levels of tau, A beta1-40, and A beta1-42(43) in Alzheimer's disease: a study in Japan.
Annals of neurology 1998;44(1):17-26.
1998: Iwatsubo T; Hisaka A; Suzuki H; Sugiyama Y
Prediction of in vivo nonlinear first-pass hepatic metabolism of YM796 from in vitro metabolic data.
The Journal of pharmacology and experimental therapeutics 1998;286(1):122-7.
1998: Oyama F; Sawamura N; Kobayashi K; Morishima-Kawashima M; Kuramochi T; Ito M; Tomita T; Maruyama K; Saido T C; Iwatsubo T; Capell A; Walter J; Grünberg J; Ueyama Y; Haass C; Ihara Y
Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain.
Journal of neurochemistry 1998;71(1):313-22.
1998: Mann D M; Brown S M; Owen F; Baba M; Iwatsubo T
Amyloid beta protein (A beta) deposition in dementia with Lewy bodies: predominance of A beta 42(43) and paucity of A beta 40 compared with sporadic Alzheimer's disease.
Neuropathology and applied neurobiology 1998;24(3):187-94.
1998: Shinozaki K; Maruyama K; Kume H; Tomita T; Saido T C; Iwatsubo T; Obata K
The presenilin 2 loop domain interacts with the mu-calpain C-terminal region.
International journal of molecular medicine 1998;1(5):797-9.
1998: Baba M; Nakajo S; Tu P H; Tomita T; Nakaya K; Lee V M; Trojanowski J Q; Iwatsubo T
Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.
The American journal of pathology 1998;152(4):879-84.
1998: Tomita T; Chang T Y; Kodama T; Iwatsubo T
BetaAPP gamma-secretase and SREBP site 2 protease are two different enzymes.
Neuroreport 1998;9(5):911-3.
1998: Iwatsubo T
Amyloid beta protein in plasma as a diagnostic marker for Alzheimer's disease.
Neurobiology of aging 1998;19(2):161-3.
1998: Tokuhiro S; Tomita T; Iwata H; Kosaka T; Saido T C; Maruyama K; Iwatsubo T
The presenilin 1 mutation (M146V) linked to familial Alzheimer's disease attenuates the neuronal differentiation of NTera 2 cells.
Biochemical and biophysical research communications 1998;244(3):751-5.
1998: Sakai K; Homma H; Lee J A; Fukushima T; Santa T; Tashiro K; Iwatsubo T; Imai K
Localization of D-aspartic acid in elongate spermatids in rat testis.
Archives of biochemistry and biophysics 1998;351(1):96-105.
1998: Schmidt M L; Lee V M; Saido T; Perl D; Schuck T; Iwatsubo T; Trojanowski J Q
Amyloid plaques in Guam amyotrophic lateral sclerosis/parkinsonism-dementia complex contain species of A beta similar to those found in the amyloid plaques of Alzheimer's disease and pathological aging.
Acta neuropathologica 1998;95(2):117-22.
1998: Iwatsubo T
Abeta42, presenilins, and Alzheimer's disease.
Neurobiology of aging 1998;19(1 Suppl):S11-3.
1998: Ito K; Iwatsubo T; Kanamitsu S; Nakajima Y; Sugiyama Y
Quantitative prediction of in vivo drug clearance and drug interactions from in vitro data on metabolism, together with binding and transport.
Annual review of pharmacology and toxicology 1998;38():461-99.
1997: Iwatsubo T; Suzuki H; Sugiyama Y
Prediction of species differences (rats, dogs, humans) in the in vivo metabolic clearance of YM796 by the liver from in vitro data.
The Journal of pharmacology and experimental therapeutics 1997;283(2):462-9.
1997: Galvin J E; Lee V M; Baba M; Mann D M; Dickson D W; Yamaguchi H; Schmidt M L; Iwatsubo T; Trojanowski J Q
Monoclonal antibodies to purified cortical Lewy bodies recognize the mid-size neurofilament subunit.
Annals of neurology 1997;42(4):595-603.
1997: Sakurai Y; Matsumura K; Iwatsubo T; Momose T
Frontal pure agraphia for kanji or kana: dissociation between morphology and phonology.
Neurology 1997;49(4):946-52.
1997: Cook D G; Forman M S; Sung J C; Leight S; Kolson D L; Iwatsubo T; Lee V M; Doms R W
Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells.
Nature medicine 1997;3(9):1021-3.
1997: Tashiro K; Hasegawa M; Ihara Y; Iwatsubo T
Somatodendritic localization of phosphorylated tau in neonatal and adult rat cerebral cortex.
Neuroreport 1997;8(12):2797-801.
1997: Iwatsubo T; Suzuki H; Shimada N; Chiba K; Ishizaki T; Green C E; Tyson C A; Yokoi T; Kamataki T; Sugiyama Y
Prediction of in vivo hepatic metabolic clearance of YM796 from in vitro data by use of human liver microsomes and recombinant P-450 isozymes.
The Journal of pharmacology and experimental therapeutics 1997;282(2):909-19.
1997: Sakai K; Homma H; Lee J A; Fukushima T; Santa T; Tashiro K; Iwatsubo T; Imai K
D-aspartic acid localization during postnatal development of rat adrenal gland.
Biochemical and biophysical research communications 1997;235(2):433-6.
1997: Takamatsu J; Kimura T; Kondo A; Iwatsubo T
Subpial amyloid plaques in the cerebellum in a case of Alzheimer's disease.
Dementia and geriatric cognitive disorders 1997;8(3):157-62.
1997: Kosaka T; Imagawa M; Seki K; Arai H; Sasaki H; Tsuji S; Asami-Odaka A; Fukushima T; Imai K; Iwatsubo T
The beta APP717 Alzheimer mutation increases the percentage of plasma amyloid-beta protein ending at A beta42(43).
Neurology 1997;48(3):741-5.
1997: Tomita T; Maruyama K; Saido T C; Kume H; Shinozaki K; Tokuhiro S; Capell A; Walter J; Grünberg J; Haass C; Iwatsubo T; Obata K
The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(5):2025-30.
1997: Lee J A; Homma H; Sakai K; Fukushima T; Santa T; Tashiro K; Iwatsubo T; Yoshikawa M; Imai K
Immunohistochemical localization of D-aspartate in the rat pineal gland.
Biochemical and biophysical research communications 1997;231(2):505-8.
1997: Mann D M; Pickering-Brown S M; Bayatti N N; Wright A E; Owen F; Iwatsubo T; Saido T C
An intronic polymorphism in the presenilin-1 gene does not influence the amount or molecular form of the amyloid beta protein deposited in Alzheimer's disease.
Neuroscience letters 1997;222(1):57-60.
1997: Mann D M; Iwatsubo T; Pickering-Brown S M; Owen F; Saido T C; Perry R H
Preferential deposition of amyloid beta protein (Abeta) in the form Abeta40 in Alzheimer's disease is associated with a gene dosage effect of the apolipoprotein E E4 allele.
Neuroscience letters 1997;221(2-3):81-4.
1997: Mann D M; Iwatsubo T; Nochlin D; Sumi S M; Levy-Lahad E; Bird T D
Amyloid (Abeta) deposition in chromosome 1-linked Alzheimer's disease: the Volga German families.
Annals of neurology 1997;41(1):52-7.
1997: Nishimoto I; Okamoto T; Giambarella U; Iwatsubo T
Apoptosis in neurodegenerative diseases.
Advances in pharmacology (San Diego, Calif.) 1997;41():337-68.
1997: Iwatsubo T; Hirota N; Ooie T; Suzuki H; Shimada N; Chiba K; Ishizaki T; Green C E; Tyson C A; Sugiyama Y
Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data.
Pharmacology & therapeutics 1997;73(2):147-71.
1996: Iwatsubo T; Saido T C; Mann D M; Lee V M; Trojanowski J Q
Full-length amyloid-beta (1-42(43)) and amino-terminally modified and truncated amyloid-beta 42(43) deposit in diffuse plaques.
The American journal of pathology 1996;149(6):1823-30.
1996: Maruyama K; Tomita T; Shinozaki K; Kume H; Asada H; Saido T C; Ishiura S; Iwatsubo T; Obata K
Familial Alzheimer's disease-linked mutations at Val717 of amyloid precursor protein are specific for the increased secretion of A beta 42(43).
Biochemical and biophysical research communications 1996;227(3):730-5.
1996: Saido T C; Yamao-Harigaya W; Iwatsubo T; Kawashima S
Amino- and carboxyl-terminal heterogeneity of beta-amyloid peptides deposited in human brain.
Neuroscience letters 1996;215(3):173-6.
1996: Kanemaru K; Iwatsubo T; Ihara Y
Comparable amyloid beta-protein (A beta) 42(43) and A beta 40 deposition in the aged monkey brain.
Neuroscience letters 1996;214(2-3):196-8.
1996: Mann D M; Iwatsubo T; Cairns N J; Lantos P L; Nochlin D; Sumi S M; Bird T D; Poorkaj P; Hardy J; Hutton M; Prihar G; Crook R; Rossor M N; Haltia M
Amyloid beta protein (Abeta) deposition in chromosome 14-linked Alzheimer's disease: predominance of Abeta42(43).
Annals of neurology 1996;40(2):149-56.
1996: Mann D M; Iwatsubo T
Diffuse plaques in the cerebellum and corpus striatum in Down's syndrome contain amyloid beta protein (A beta) only in the form of A beta 42(43).
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 1996;5(2):115-20.
1996: Iwatsubo T; Yamaguchi H; Fujimuro M; Yokosawa H; Ihara Y; Trojanowski J Q; Lee V M
Lewy bodies: purification from diffuse Lewy body disease brains.
Annals of the New York Academy of Sciences 1996;786():195-205.
1996: Yamatsuji T; Matsui T; Okamoto T; Komatsuzaki K; Takeda S; Fukumoto H; Iwatsubo T; Suzuki N; Asami-Odaka A; Ireland S; Kinane T B; Giambarella U; Nishimoto I
G protein-mediated neuronal DNA fragmentation induced by familial Alzheimer's disease-associated mutants of APP.
Science (New York, N.Y.) 1996;272(5266):1349-52.
1996: Iwatsubo T; Yamaguchi H; Fujimuro M; Yokosawa H; Ihara Y; Trojanowski J Q; Lee V M
Purification and characterization of Lewy bodies from the brains of patients with diffuse Lewy body disease.
The American journal of pathology 1996;148(5):1517-29.
1996: Mann D M; Iwatsubo T; Ihara Y; Cairns N J; Lantos P L; Bogdanovic N; Lannfelt L; Winblad B; Maat-Schieman M L; Rossor M N
Predominant deposition of amyloid-beta 42(43) in plaques in cases of Alzheimer's disease and hereditary cerebral hemorrhage associated with mutations in the amyloid precursor protein gene.
The American journal of pathology 1996;148(4):1257-66.
1996: Nakano I; Iwatsubo T; Otsuka N; Kamei M; Matsumura K; Mannen T
Some unusual responses of astrocytes to ghost tangles in a long duration case of juvenile Alzheimer's disease: an electron microscopic study.
Journal of the neurological sciences 1996;136(1-2):41-6.
1996: Fukumoto H; Asami-Odaka A; Suzuki N; Iwatsubo T
Association of A beta 40-positive senile plaques with microglial cells in the brains of patients with Alzheimer's disease and in non-demented aged individuals.
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 1996;5(1):13-7.
1996: Kume H; Maruyama K; Tomita T; Iwatsubo T; Saido T C; Obata K
Molecular cloning of a novel basic helix-loop-helix protein from the rat brain.
Biochemical and biophysical research communications 1996;219(2):526-30.
1996: Fukumoto H; Asami-Odaka A; Suzuki N; Shimada H; Ihara Y; Iwatsubo T
Amyloid beta protein deposition in normal aging has the same characteristics as that in Alzheimer's disease. Predominance of A beta 42(43) and association of A beta 40 with cored plaques.
The American journal of pathology 1996;148(1):259-65.
1996: Mann D M; Iwatsubo T; Snowden J S
Atypical amyloid (A beta) deposition in the cerebellum in Alzheimer's disease: an immunohistochemical study using end-specific A beta monoclonal antibodies.
Acta neuropathologica 1996;91(6):647-53.
1995: Mann D M; Pickering-Brown S M; Siddons M A; Iwatsubo T; Ihara Y; Asami-Odaka A; Suzuki N
The extent of amyloid deposition in brain in patients with Down's syndrome does not depend upon the apolipoprotein E genotype.
Neuroscience letters 1995;196(1-2):105-8.
1995: Iwatsubo T; Mann D M; Odaka A; Suzuki N; Ihara Y
Amyloid beta protein (A beta) deposition: A beta 42(43) precedes A beta 40 in Down syndrome.
Annals of neurology 1995;37(3):294-9.
1995: Saido T C; Iwatsubo T; Mann D M; Shimada H; Ihara Y; Kawashima S
Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques.
Neuron 1995;14(2):457-66.
1995: Mann D M; Iwatsubo T; Fukumoto H; Ihara Y; Odaka A; Suzuki N
Microglial cells and amyloid beta protein (A beta) deposition; association with A beta 40-containing plaques.
Acta neuropathologica 1995;90(5):472-7.
1994: Arai H; Higuchi S; Muramatsu T; Iwatsubo T; Sasaki H; Trojanowski J Q
Apolipoprotein E gene in diffuse Lewy body disease with or without co-existing Alzheimer's disease.
Lancet 1994;344(8932):1307.
1994: Suzuki N; Iwatsubo T; Odaka A; Ishibashi Y; Kitada C; Ihara Y
High tissue content of soluble beta 1-40 is linked to cerebral amyloid angiopathy.
The American journal of pathology 1994;145(2):452-60.
1994: Iwatsubo T; Odaka A; Suzuki N; Mizusawa H; Nukina N; Ihara Y
Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).
Neuron 1994;13(1):45-53.
1994: Iwatsubo T; Hasegawa M; Ihara Y
Neuronal and glial tau-positive inclusions in diverse neurologic diseases share common phosphorylation characteristics.
Acta neuropathologica 1994;88(2):129-36.
1993: Iwatsubo T; Kanemitsu A
[The pyramidal tract in man]
No to shinkei = Brain and nerve 1993;45(1):21-37.
1993: Endoh R; Ogawara M; Iwatsubo T; Nakano I; Mori H
Lack of the carboxyl terminal sequence of tau in ghost tangles of Alzheimer's disease.
Brain research 1993;601(1-2):164-72.
1993: Nakano I; Iwatsubo T; Hashizume Y; Mizutani T
Bunina bodies in neurons of the medullary reticular formation in amyotrophic lateral sclerosis.
Acta neuropathologica 1993;85(5):471-4.
1992: Iwatsubo T
[Japanese clinical statistical data of progressive supranuclear palsy]
Nippon rinsho. Japanese journal of clinical medicine 1992;50 Suppl():134-8.
1992: Sonoo M; Genba K; Iwatsubo T; Mannen T
P15 in tibial nerve SEPs as an example of the junctional potential.
Electroencephalography and clinical neurophysiology 1992;84(6):486-91.
1992: Bito H; Nakamura M; Honda Z; Izumi T; Iwatsubo T; Seyama Y; Ogura A; Kudo Y; Shimizu T
Platelet-activating factor (PAF) receptor in rat brain: PAF mobilizes intracellular Ca2+ in hippocampal neurons.
Neuron 1992;9(2):285-94.
1992: Iwatsubo T; Hasegawa M; Esaki Y; Ihara Y
Lack of ubiquitin immunoreactivities at both ends of neuropil threads. Possible bidirectional growth of neuropil threads.
The American journal of pathology 1992;140(2):277-82.
1992: Nakano I; Iwatsubo T; Otsuka N; Kamei M; Matsumura K; Mannen T
Paired helical filaments in astrocytes: electron microscopy and immunohistochemistry in a case of atypical Alzheimer's disease.
Acta neuropathologica 1992;83(3):228-32.
1992: Takahashi N; Iwatsubo T; Nakano I; Machinami R
Focal appearance of cerebellar torpedoes associated with discrete lesions in the cerebellar white matter.
Acta neuropathologica 1992;84(2):153-6.
1991: Iwatsubo T; Nakano I; Fukunaga K; Miyamoto E
Ca2+/calmodulin-dependent protein kinase II immunoreactivity in Lewy bodies.
Acta neuropathologica 1991;82(3):159-63.
1990: Iwatsubo T; Kuzuhara S; Kanemitsu A; Shimada H; Toyokura Y
Corticofugal projections to the motor nuclei of the brainstem and spinal cord in humans.
Neurology 1990;40(2):309-12.
1989: Iwatsubo T; Sakanaka C; Obi T; Takeda K; Sakuta M
[Chronic inflammatory demyelinating polyradiculoneuropathy of acute onset: relapse after temporary improvement by plasma exchange and longstanding remission by corticosteroid therapy]
Rinsho shinkeigaku = Clinical neurology 1989;29(7):930-2.
1988: Iwatsubo T; Arahata K; Motoyoshi Y; Murayama S; Mannen T
[Co-existence of clinical and immunohistochemical features of polymyositis and myasthenia gravis]
Rinsho shinkeigaku = Clinical neurology 1988;28(8):913-8.
1988: Okazawa H; Moriuchi I; Iwatsubo T; Takeda K; Sakuta M
[Bilateral horizontal gaze palsy due to hemi-tegmental lesion in a case of pontine infarction]
Rinsho shinkeigaku = Clinical neurology 1988;28(7):803-7.
1988: Iwatsubo T; Yamada H; Kawakami H; Hirokawa K; Sonobe M
[On the mechanism of symptomatic development in syringomyelobulbia]
Rinsho shinkeigaku = Clinical neurology 1988;28(2):129-32.
1987: Iwatsubo T; Iwata M; Inoue K; Mannen T
[Magnetic resonance imaging in a case of paramedian mesencephalic infarction]
Revue neurologique 1987;143(8-9):605-7.

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