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Takeshi Iwatsubo

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Alzheimer's Disease

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Shizuka Takagi-Niidome; Taisuke Tomita; Satoko Osawa; Takeshi Iwatsubo
Inhibition of γ-secretase activity by a monoclonal antibody against the extracellular hydrophilic loop of presenilin 1.
Nobumasa Takasugi; Koji Takeo; Taisuke Tomita; Ihori Ebinuma; Hayato Isshiki; Satoko Osawa; Tomoki Sasaki; Takeshi Iwatsubo
FTY720/Fingolimod, a Sphingosine Analogue, Reduces Amyloid-β Production in Neurons.
Kunimichi Suzuki; Shun Tanimura; Taisuke Tomita; Satoshi Yokoshima; Mingshuo Zeng; Tohru Fukuyama; Yukari Hayashi; Keisuke Horiuchi; Ryuta Koyama; Hiroshi Kumazaki; Norio Matsuki; Soichiro Nakahara; Yoshitake Nishiyama; Satoko Osawa; Johannes Prox; Paul Saftig; Atsuko Sehara-Fujisawa; Takeshi Iwatsubo
Activity-dependent proteolytic cleavage of neuroligin-1.

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All Publications

2013: Shizuka Takagi-Niidome; Taisuke Tomita; Satoko Osawa; Takeshi Iwatsubo
Inhibition of γ-secretase activity by a monoclonal antibody against the extracellular hydrophilic loop of presenilin 1.
Biochemistry 2013;52(1):61-9.
2013: Nobumasa Takasugi; Koji Takeo; Taisuke Tomita; Ihori Ebinuma; Hayato Isshiki; Satoko Osawa; Tomoki Sasaki; Takeshi Iwatsubo
FTY720/Fingolimod, a Sphingosine Analogue, Reduces Amyloid-β Production in Neurons.
PloS one 2013;8(5):e64050.
2012: Kunimichi Suzuki; Shun Tanimura; Taisuke Tomita; Satoshi Yokoshima; Mingshuo Zeng; Tohru Fukuyama; Yukari Hayashi; Keisuke Horiuchi; Ryuta Koyama; Hiroshi Kumazaki; Norio Matsuki; Soichiro Nakahara; Yoshitake Nishiyama; Satoko Osawa; Johannes Prox; Paul Saftig; Atsuko Sehara-Fujisawa; Takeshi Iwatsubo
Activity-dependent proteolytic cleavage of neuroligin-1.
Neuron 2012;76(2):410-22.
2012: Masami Goto; Naoto Hayashi; Kenji Ino; Takeshi Iwatsubo; Hiroyuki Kabasawa; Akira Kunimatsu; Tomomi Kurosu; Hiroshi Matsuda; Tosiaki Miyati; Harushi Mori; Kuni Ohtomo; Hidemasa Takao; Fumio Yamashita; Keiichi Yano; Osamu Abe; Shigeki Aoki
Influence of signal intensity non-uniformity on brain volumetry using an atlas-based method.
Korean journal of radiology : official journal of the Korean Radiological Society 2012;13(4):391-402.
2012: Emanuela Colla; Philippe Coune; Takeshi Iwatsubo; Ying Liu; Olga Pletnikova; Bernard L Schneider; Juan C Troncoso; Michael K Lee
Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(10):3306-20.
2012: Ikuo Hayashi; Hiroko Iwanari; S Chiba; Takao Hamakubo; Tatsuhiko Kodama; Tong Li; Y Miyake; Yuichi Morohashi; S Osawa; Mamiko Sakata-Yanagimoto; J Takagi; S Takatori; Taisuke Tomita; Yasuomi Urano; Philip C Wong; Takeshi Iwatsubo
Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin.
Oncogene 2012;31(6):787-98.
2012: Genta Ito; Takeshi Iwatsubo
Re-examination of the dimerization state of leucine-rich repeat kinase 2: predominance of the monomeric form.
The Biochemical journal 2012;441(3):987-94.
2012: Masami Goto; Naoto Hayashi; Sachiko Inano; Kenji Ino; Takeshi Iwatsubo; Hiroyuki Kabasawa; Akira Kunimatsu; Tomomi Kurosu; Hiroshi Matsuda; Tosiaki Miyati; Harushi Mori; Kuni Ohtomo; Hidemasa Takao; Fumio Yamashita; Keiichi Yano; Osamu Abe; Shigeki Aoki
Effects of image distortion correction on voxel-based morphometry.
Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine 2012;11(1):27-34.
2011: Yu Ohki; Satoko Osawa; Naoaki Shimada; Taisuke Tomita; Kengo Uemura; Satoshi Yokoshima; Oksana Berezovska; Tohru Fukuyama; Takuya Higo; Takeshi Iwatsubo
Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1.
The EMBO journal 2011;30(23):4815-24.
2011: Takeshi Iwatsubo
[Alzheimer's disease Neuroimaging Initiative (ADNI)].
Nihon rinsho. Japanese journal of clinical medicine 2011;69 Suppl 8():570-4.
2011: Takeshi Iwatsubo
[Dementia: progress in diagnosis and treatment; editorial, towards the preclinical treatment of Alzheimer disease].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2011;100(8):2089-91.
2011: Masachika Fujiyoshi; Tadafumi Hashimoto; Ken-Ichi Hosoya; Shingo Ito; Takeshi Iwatsubo; Junichi Kamiie; Sumio Ohtsuki; Masanori Tachikawa; Shin-Ichi Akanuma; Yasuo Uchida; Tetsuya Terasaki
Amyloid-β peptide(1-40) elimination from cerebrospinal fluid involves low-density lipoprotein receptor-related protein 1 at the blood-cerebrospinal fluid barrier.
Journal of neurochemistry 2011;118(3):407-15.
2011: Hiroyuki Miyashita; Toshihiko Ogura; Satoko Osawa; Chikara Sato; Taisuke Tomita; Hayato Isshiki; Yuusuke Maruyama; Kazuhiro Mio; Takeshi Iwatsubo
Three-dimensional structure of the signal peptide peptidase.
The Journal of biological chemistry 2011;286(29):26188-97.
2011: Nobumasa Takasugi; Taisuke Tomita; John Q Trojanowski; Satoshi Yokoshima; Tohru Fukuyama; Takuya Higo; Yukiko Hori; Hayato Isshiki; Virginia M-Y Lee; Satoko Osawa; Tomoki Sasaki; Naoaki Shimada; Kunimichi Suzuki; Takeshi Iwatsubo
BACE1 activity is modulated by cell-associated sphingosine-1-phosphate.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(18):6850-7.
2011: Reisa Sperling; Paul S Aisen; Laurel Beckett; David A Bennett; Suzanne Craft; Anne M Fagan; Takeshi Iwatsubo; Clifford R Jack; Jeffrey A Kaye; Thomas J Montine; Denise C Park; Eric Reiman; Christopher C Rowe; Eric Siemers; Yaakov Stern; Kristine Yaffe; Maria C Carrillo; Bill Thies; Marcelle Morrison-Bogorad; Molly V Wagster; Creighton H Phelps
Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2011;7(3):280-92.
2011: Takuya Tamura; Erich E Wanker; Takeshi Iwatsubo; Masaki Sone; Kazuhiko Tagawa; Hitoshi Okazawa
Ku70 alleviates neurodegeneration in Drosophila models of Huntington's disease.
PloS one 2011;6(11):e27408.
2011: Takeshi Iwatsubo
[Molecular pathology and disease-modifying therapy of Alzheimer disease].
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica 2011;113(6):568-73.
2010: Masashi Asai; Nobuhisa Iwata; Taisuke Tomita; Takeshi Iwatsubo; Shoichi Ishiura; Takaomi C Saido; Kei Maruyama
Efficient four-drug cocktail therapy targeting amyloid-β peptide for Alzheimer's disease.
Journal of neuroscience research 2010;88(16):3588-97.
2010: Shizuka Takagi; Aya Tominaga; Chihiro Sato; Taisuke Tomita; Takeshi Iwatsubo
Participation of transmembrane domain 1 of presenilin 1 in the catalytic pore structure of the γ-secretase.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(47):15943-50.
2010: Takashi Nonaka; Sayuri T Watanabe; Takeshi Iwatsubo; Masato Hasegawa
Seeded aggregation and toxicity of {alpha}-synuclein and tau: cellular models of neurodegenerative diseases.
The Journal of biological chemistry 2010;285(45):34885-98.
2010: Takeshi Iwatsubo
J-ADNI.
Rinshō shinkeigaku = Clinical neurology 2010;50(11):935.
2010: Yuichi Morohashi; Taisuke Tomita; Takeshi Iwatsubo
[Molecular targeted therapy in Alzheimer disease].
Nihon rinsho. Japanese journal of clinical medicine 2010;68(10):1906-10.
2010: Motonori Kurosumi; Yoshino Nishio; Satoko Osawa; Hisayoshi Kobayashi; Takeshi Iwatsubo; Taisuke Tomita; Hiroyuki Miyachi
Novel Notch-sparing gamma-secretase inhibitors derived from a peroxisome proliferator-activated receptor agonist library.
Bioorganic & medicinal chemistry letters 2010;20(17):5282-5.
2010: Hiroaki Fukumoto; Hideki Takahashi; Naoki Tarui; Junji Matsui; Taisuke Tomita; Mitsuhiro Hirode; Masumi Sagayama; Ryouta Maeda; Makiko Kawamoto; Kazuko Hirai; Jun Terauchi; Yasufumi Sakura; Mitsuru Kakihana; Kaneyoshi Kato; Takeshi Iwatsubo; Masaomi Miyamoto
A noncompetitive BACE1 inhibitor TAK-070 ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(33):11157-66.
2010: Naoto Watanabe; Image Image Image Image; Shizuka Takagi; Image Image Image Image; Aya Tominaga; Image Image Image; Taisuke Tomita; Image Image Image Image; Takeshi Iwatsubo; Image Image Image
Functional analysis of the transmembrane domains of presenilin 1: participation of transmembrane domains 2 and 6 in the formation of initial substrate-binding site of gamma-secretase.
The Journal of biological chemistry 2010;285(26):19738-46.
2010: Takeshi Iwatsubo
Japanese Alzheimer's Disease Neuroimaging Initiative: present status and future.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2010;6(3):297-9.
2010: King-Ho Cheung; Lijuan Mei; Don-On Daniel Mak; Ikuo Hayashi; Takeshi Iwatsubo; David E Kang; J Kevin Foskett
Gain-of-function enhancement of IP3 receptor modal gating by familial Alzheimer's disease-linked presenilin mutants in human cells and mouse neurons.
Science signaling 2010;3(114):ra22.
2009: Satoshi Yokoshima; Yuzo Abe; Naoto Watanabe; Yoichi Kita; Toshiyuki Kan; Takeshi Iwatsubo; Taisuke Tomita; Tohru Fukuyama
Development of photoaffinity probes for gamma-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker.
Bioorganic & medicinal chemistry letters 2009;19(24):6869-71.
2009: Shigeo Masuda; Keiki Kumano; Takahiro Suzuki; Taisuke Tomita; Takeshi Iwatsubo; Hideaki Natsugari; Arinobu Tojo; Makoto Shibutani; Kunitoshi Mitsumori; Yutaka Hanazono; Seishi Ogawa; Mineo Kurokawa; Shigeru Chiba
Dual antitumor mechanisms of Notch signaling inhibitor in a T-cell acute lymphoblastic leukemia xenograft model.
Cancer science 2009;100(12):2444-50.
2009: Shogo Kamikawaji; Genta Ito; Takeshi Iwatsubo
Identification of the autophosphorylation sites of LRRK2.
Biochemistry 2009;48(46):10963-75.
2009: J Chapuis; D Hot; Franck Hansmannel; O Kerdraon; S Ferreira; C Hubans; C A Maurage; L Huot; F Bensemain; G Laumet; A M Ayral; N Fievet; JEAN-JACQUES HAUW; Steven T DeKosky; Yves LEMOINE; Takeshi Iwatsubo; F Wavrant-Devrièze; Jean-François Dartigues; C Tzourio; L Buée; Florence Pasquier; C Berr; D M A Mann; Corinne Lendon; A Alpérovitch; M I Kamboh; Philippe Amouyel; jean-charles lambert
Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.
Molecular psychiatry 2009;14(11):1004-16.
2009: Ikuo Hayashi; Sho Takatori; Yasuomi Urano; Hiroko Iwanari; Noriko Isoo; Satoko Osawa; Maiko A Fukuda; Tatsuhiko Kodama; Takao Hamakubo; Tong Li; Philip C Wong; Taisuke Tomita; Takeshi Iwatsubo
Single chain variable fragment against nicastrin inhibits the gamma-secretase activity.
The Journal of biological chemistry 2009;284(41):27838-47.
2009: Kaoru Yamada; Chiori Yabuki; Peter Seubert; Dale Schenk; Yukiko Hori; Sumio Ohtsuki; Tetsuya Terasaki; Tadafumi Hashimoto; Takeshi Iwatsubo
Abeta immunotherapy: intracerebral sequestration of Abeta by an anti-Abeta monoclonal antibody 266 with high affinity to soluble Abeta.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(36):11393-8.
2009: Shamol Saha; Maria D Guillily; Andrew Ferree; Joel Lanceta; Diane Chan; Joy Ghosh; Cindy H Hsu; Lilach Segal; Kesav Raghavan; Kunihiro Matsumoto; Naoki Hisamoto; Tomoki Kuwahara; Takeshi Iwatsubo; Landon Moore; Lee Goldstein; Mark Cookson; Benjamin Wolozin
LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(29):9210-8.
2009: Yuki Imamura; Naoto Watanabe; Naoki Umezawa; Takeshi Iwatsubo; Nobuki Kato; Taisuke Tomita; Tsunehiko Higuchi
Inhibition of gamma-secretase activity by helical beta-peptide foldamers.
Journal of the American Chemical Society 2009;131(21):7353-9.
2009: Nao Shimizu; Hajime Watanabe; Junko Kubota; Jinzhan Wu; Ryota Saito; Tadashi Yokoi; Takumi Era; Takeshi Iwatsubo; Takashi Watanabe; Sachiko Nishina; Noriyuki Azuma; Toshiaki Katada; Hiroshi Nishina
Pax6-5a promotes neuronal differentiation of murine embryonic stem cells.
Biological & pharmaceutical bulletin 2009;32(6):999-1003.
2009: Samareh Azeredo da Silveira; Bernard L Schneider; Carmen Cifuentes-Diaz; Daniel Sage; Toufik Abbas-Terki; Takeshi Iwatsubo; Michaël Unser; Patrick Aebischer
Phosphorylation does not prompt, nor prevent, the formation of alpha-synuclein toxic species in a rat model of Parkinson's disease.
Human molecular genetics 2009;18(5):872-87.
2009: Haipeng Cheng; Kulandaivelu S Vetrivel; Renaldo C Drisdel; Xavier Meckler; Ping Gong; Jae Yoon Leem; Tong Li; Meghan Carter; Ying Chen; Phuong Nguyen; Takeshi Iwatsubo; Taisuke Tomita; Philip C Wong; William N Green; Maria Z Kounnas; Gopal Thinakaran
S-palmitoylation of gamma-secretase subunits nicastrin and APH-1.
The Journal of biological chemistry 2009;284(3):1373-84.
2008: K Yamada; Tadafumi Hashimoto; Chiori Yabuki; Yusuke Nagae; Masanori Tachikawa; Dudley K Strickland; Qiang Liu; Guojun Bu; Jacob Basak; David M Holtzman; Sumio Ohtsuki; Tetsuya Terasaki; Takeshi Iwatsubo
The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid beta peptides in an in vitro model of the blood-brain barrier cells.
The Journal of biological chemistry 2008;283(50):34554-62.
2008: Y Laras; N Pietrancosta; T Tomita; Takeshi Iwatsubo; J L Kraus
Synthesis and biological activity of N-substituted spiro[benzoxazepine-piperidine] Abeta-peptide production inhibitors.
Journal of enzyme inhibition and medicinal chemistry 2008;23(6):996-1001.
2008: Masako Ikemura; Yuko Saito; Renpei Sengoku; Yoshio Sakiyama; Hiroyuki Hatsuta; Kazutomi Kanemaru; Motoji Sawabe; Tomio Arai; Genta Ito; Takeshi Iwatsubo; Masashi Fukayama; Shigeo Murayama
Lewy body pathology involves cutaneous nerves.
Journal of neuropathology and experimental neurology 2008;67(10):945-53.
2008: Tomoki Kuwahara; Akihiko Koyama; Shingo Koyama; Sawako Yoshina; Chang-Hong Ren; Takeo Kato; Shohei Mitani; Takeshi Iwatsubo
A systematic RNAi screen reveals involvement of endocytic pathway in neuronal dysfunction in alpha-synuclein transgenic C. elegans.
Human molecular genetics 2008;17(19):2997-3009.
2008: Christophe Lo Bianco; James Shorter; Etienne Régulier; Hilal Lashuel; Takeshi Iwatsubo; Susan Lindquist; Patrick Aebischer
Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease.
The Journal of clinical investigation 2008;118(9):3087-97.
2008: Thomas Beach; Charles L White; Ronald L Hamilton; John E Duda; Takeshi Iwatsubo; dennis dickson; James B Leverenz; Federico Roncaroli; Manuel Buttini; Christa L Hladik; Lucia I Sue; Joseph V Noorigian; Charles H Adler
Evaluation of alpha-synuclein immunohistochemical methods used by invited experts.
Acta neuropathologica 2008;116(3):277-88.
2008: King-Ho Cheung; Diana Shineman; Marioly Müller; César Cárdenas; Lijuan Mei; Jun Yang; Taisuke Tomita; Takeshi Iwatsubo; Virginia M-Y Lee; J Kevin Foskett
Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating.
Neuron 2008;58(6):871-83.
2008: Chihiro Sato; Shizuka Takagi; Taisuke Tomita; Takeshi Iwatsubo
The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(24):6264-71.
2008: Shin-ichi Akanuma; Sumio Ohtsuki; Youko Doi; Masanori Tachikawa; Shingo Ito; Satoko Hori; Tomoko Asashima; Tadafumi Hashimoto; Kaoru Yamada; Kazumitsu Ueda; Takeshi Iwatsubo; Tetsuya Terasaki
ATP-binding cassette transporter A1 (ABCA1) deficiency does not attenuate the brain-to-blood efflux transport of human amyloid-beta peptide (1-40) at the blood-brain barrier.
Neurochemistry international 2008;52(6):956-61.
2008: Takeshi Ikeuchi; Akiyoshi Kakita; Atsushi Shiga; Kensaku Kasuga; Hiryoyuki Kaneko; Chun-Feng Tan; Jiro Idezuka; Koichi Wakabayashi; Osamu Onodera; Takeshi Iwatsubo; Masatoyo Nishizawa; Hitoshi Takahashi; Atsushi Ishikawa
Patients homozygous and heterozygous for SNCA duplication in a family with parkinsonism and dementia.
Archives of neurology 2008;65(4):514-9.
2008: Tomoki Yoshihara; Sho Takiguchi; Akifumi Kyuno; Koichi Tanaka; Sayaka Kuba; Shuhei Hashiguchi; Yuji Ito; Tadafumi Hashimoto; Takeshi Iwatsubo; Shinichiro Tsuyama; Toshihiro Nakashima; Kazuhisa Sugimura
Immunoreactivity of phage library-derived human single-chain antibodies to amyloid beta conformers in vitro.
Journal of biochemistry 2008;143(4):475-86.
2008: Kimiko Obi; Haruhiko Akiyama; Hiromi Kondo; Yoko Shimomura; Masato Hasegawa; Takeshi Iwatsubo; Yoshikuni Mizuno; Hideki Mochizuki
Relationship of phosphorylated alpha-synuclein and tau accumulation to Abeta deposition in the cerebral cortex of dementia with Lewy bodies.
Experimental neurology 2008;210(2):409-20.
2008: Masaki Wakamatsu; Aiko Ishii; Shingo Iwata; Junko Sakagami; Yuriko Ukai; Mieko Ono; Daiji Kanbe; Shin-ichi Muramatsu; Kazuto Kobayashi; Takeshi Iwatsubo; Makoto Yoshimoto
Selective loss of nigral dopamine neurons induced by overexpression of truncated human alpha-synuclein in mice.
Neurobiology of aging 2008;29(4):574-85.
2008: Tomoko Ichibangase; Hiroshi Saimaru; Norio Takamura; Tomoki Kuwahara; Akihiko Koyama; Takeshi Iwatsubo; Kazuhiro Imai
Proteomics of Caenorhabditis elegans over-expressing human alpha-synuclein analyzed by fluorogenic derivatization-liquid chromatography/tandem mass spectrometry: identification of actin and several ribosomal proteins as negative markers at early Parkinson's disease stages.
Biomedical chromatography : BMC 2008;22(3):232-4.
2008: Keiki Kumano; Shigeo Masuda; Masataka Sata; Toshiki Saito; Suk-Young Lee; Mamiko Sakata-Yanagimoto; Taisuke Tomita; Takeshi Iwatsubo; Hideaki Natsugari; Mineo Kurokawa; Seishi Ogawa; Shigeru Chiba
Both Notch1 and Notch2 contribute to the regulation of melanocyte homeostasis.
Pigment cell & melanoma research 2008;21(1):70-8.
2008: Sho Takatori; Genta Ito; Takeshi Iwatsubo
Cytoplasmic localization and proteasomal degradation of N-terminally cleaved form of PINK1.
Neuroscience letters 2008;430(1):13-7.
2008: Liyan Qiao; Shusei Hamamichi; Kim A Caldwell; Guy A Caldwell; Talene A Yacoubian; Scott Wilson; Zuo-Lei Xie; Lisa D Speake; Rachael Parks; Donna Crabtree; Qiuli Liang; Stephen Crimmins; Lonnie Schneider; Yasuo Uchiyama; Takeshi Iwatsubo; Yi Zhou; Lisheng Peng; YouMing Lu; David G Standaert; Ken C Walls; John J Shacka; Kevin A Roth; Jianhua Zhang
Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity.
Molecular brain 2008;1():17.
2008: George Perry; Xiongwei Zhu; Asim K Babar; Sandra L Siedlak; Qiwei Yang; Genta Ito; Takeshi Iwatsubo; Mark A. Smith; Shu G Chen
Leucine-rich repeat kinase 2 colocalizes with alpha-synuclein in Parkinson's disease, but not tau-containing deposits in tauopathies.
Neuro-degenerative diseases 2008;5(3-4):222-4.
2007: Hiroyuki Kaneko; Akiyoshi Kakita; Kensaku Kasuga; Hiroaki Nozaki; Atsushi Ishikawa; Akinori Miyashita; Ryozo Kuwano; Genta Ito; Takeshi Iwatsubo; Hitoshi Takahashi; Masatoyo Nishizawa; Osamu Onodera; Sangram S Sisodia; Takeshi Ikeuchi
Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(48):13092-7.
2007: Hiroaki Sasakawa; Eri Sakata; Yoshiki Yamaguchi; Masami Masuda; Tetsuya Mori; Eiji Kurimoto; Takeshi Iguchi; Shin-ichi Hisanaga; Takeshi Iwatsubo; Masato Hasegawa; Koichi Kato
Ultra-high field NMR studies of antibody binding and site-specific phosphorylation of alpha-synuclein.
Biochemical and biophysical research communications 2007;363(3):795-9.
2007: Aasami Ishii; Takashi Nonaka; Sayuri Taniguchi; Taro Saito; Tetsuaki Arai; D M A Mann; Takeshi Iwatsubo; Shin-ichi Hisanaga; Michel Goedert; Masato Hasegawa
Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alpha-synuclein: Implication for alpha-synucleinopathies.
FEBS letters 2007;581(24):4711-7.
2007: Takeshi Iwatsubo
Pathological biochemistry of alpha-synucleinopathy.
Neuropathology : official journal of the Japanese Society of Neuropathology 2007;27(5):474-8.
2007: Masaru Kato; Hiroyuki Kinoshita; Mitsue Enokita; Yukiko Hori; Tadafumi Hashimoto; Takeshi Iwatsubo; Toshimasa Toyo'oka
Analytical method for beta-amyloid fibrils using CE-laser induced fluorescence and its application to screening for inhibitors of beta-amyloid protein aggregation.
Analytical chemistry 2007;79(13):4887-91.
2007: Haruhiko Fuwa; Yasuko Takahashi; Yu Konno; Naoto Watanabe; Hiroyuki Miyashita; Makoto Sasaki; Hideaki Natsugari; Toshiyuki Kan; Tohru Fukuyama; Taisuke Tomita; Takeshi Iwatsubo
Divergent synthesis of multifunctional molecular probes to elucidate the enzyme specificity of dipeptidic gamma-secretase inhibitors.
ACS chemical biology 2007;2(6):408-18.
2007: Masaki Wakamatsu; Aiko Ishii; Yuriko Ukai; Junko Sakagami; Shingo Iwata; Mieko Ono; Kayo Matsumoto; Atsushi Nakamura; Norihiro Tada; Kazuto Kobayashi; Takeshi Iwatsubo; Makoto Yoshimoto
Accumulation of phosphorylated alpha-synuclein in dopaminergic neurons of transgenic mice that express human alpha-synuclein.
Journal of neuroscience research 2007;85(8):1819-25.
2007: Toshiyuki Kan; Yoichi Kita; Yuichi Morohashi; Yusuke Tominari; Shinnosuke Hosoda; Taisuke Tomita; Hideaki Natsugari; Takeshi Iwatsubo; Tohru Fukuyama
Convenient synthesis of photoaffinity probes and evaluation of their labeling abilities.
Organic letters 2007;9(11):2055-8.
2007: Yuichi Fumimura; Masako Ikemura; Yuko Saito; Renpei Sengoku; Kazutomi Kanemaru; Motoji Sawabe; Tomio Arai; Genta Ito; Takeshi Iwatsubo; Masashi Fukayama; Hidehiro Mizusawa; Shigeo Murayama
Analysis of the adrenal gland is useful for evaluating pathology of the peripheral autonomic nervous system in lewy body disease.
Journal of neuropathology and experimental neurology 2007;66(5):354-62.
2007: Noriko Isoo; Chihiro Sato; Hiroyuki Miyashita; Mitsuru Shinohara; Nobumasa Takasugi; Yuichi Morohashi; Shoji Tsuji; Taisuke Tomita; Takeshi Iwatsubo
Abeta42 overproduction associated with structural changes in the catalytic pore of gamma-secretase: common effects of Pen-2 N-terminal elongation and fenofibrate.
The Journal of biological chemistry 2007;282(17):12388-96.
2007: Kamran Haleem; Carol F Lippa; Thomas W Smith; Hisanori Kowa; Jianlin Wu; Takeshi Iwatsubo
Presenilin-1 C410Y Alzheimer disease plaques contain synaptic proteins.
American journal of Alzheimer's disease and other dementias 2007;22(2):137-44.
2007: Ryoko Yamamoto; Eizo Iseki; Norio Murayama; Michiko Minegishi; Wami Marui; Takashi Togo; Omi Katsuse; Kenji Kosaka; Masanori Kato; Takeshi Iwatsubo; Heii Arai
Correlation in Lewy pathology between the claustrum and visual areas in brains of dementia with Lewy bodies.
Neuroscience letters 2007;415(3):219-24.
2007: Carol F Lippa; J E Duda; Murray Grossman; Howard I Hurtig; Dag Aarsland; Bradley Boeve; David J Brooks; dennis dickson; Bruno Dubois; M Emre; Stanley Fahn; J M Farmer; Douglas Galasko; James E Galvin; Christopher G Goetz; John H Growdon; Katrina Gwinn-Hardy; John Hardy; Peter Heutink; Takeshi Iwatsubo; K Kosaka; Virginia M-Y Lee; James B Leverenz; Eliezer Masliah; Ian G McKeith; Robert L Nussbaum; C Warren Olanow; B M Ravina; Andrew Singleton; Caroline M Tanner; John Q Trojanowski; Zbigniew K Wszolek
DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers.
Neurology 2007;68(11):812-9.
2007: Yukiko Hori; Tadafumi Hashimoto; Yosuke Wakutani; Katsuya Urakami; Kenji Nakashima; Margaret M Condron; Satoshi Tsubuki; Takaomi C Saido; David B Teplow; Takeshi Iwatsubo
The Tottori (D7N) and English (H6R) familial Alzheimer disease mutations accelerate Abeta fibril formation without increasing protofibril formation.
The Journal of biological chemistry 2007;282(7):4916-23.
2007: Genta Ito; Takuro Okai; Go Fujino; Kohsuke Takeda; Hidenori Ichijo; Toshiaki Katada; Takeshi Iwatsubo
GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease.
Biochemistry 2007;46(5):1380-8.
2006: Toshinori Ozaki; Yuanyuan Li; Hironobu Kikuchi; Taisuke Tomita; Takeshi Iwatsubo; Akira Nakagawara
The intracellular domain of the amyloid precursor protein (AICD) enhances the p53-mediated apoptosis.
Biochemical and biophysical research communications 2006;351(1):57-63.
2006: Helen Hsieh; Jannic Boehm; Chihiro Sato; Takeshi Iwatsubo; Taisuke Tomita; Sangram S Sisodia; Roberto Malinow
AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss.
Neuron 2006;52(5):831-43.
2006: Chihiro Sato; Yuichi Morohashi; Taisuke Tomita; Takeshi Iwatsubo
Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(46):12081-8.
2006: Eun Joo Kim; Jee Young Sung; Hyun Jung Lee; Hyewhon Rhim; Masato Hasegawa; Takeshi Iwatsubo; Do Sik Min; Jongsun Kim; Seung R Paik; Kwang Chul Chung
Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation.
The Journal of biological chemistry 2006;281(44):33250-7.
2006: Takeshi Iwatsubo
[Beta- and gamma-secretases].
Rinshō shinkeigaku = Clinical neurology 2006;46(11):925-6.
2006: Takeshi Iwatsubo
Tauopathy: an overview.
Neuropathology : official journal of the Japanese Society of Neuropathology 2006;26(5):455-6.
2006: Shigeki Arawaka; Manabu Wada; Saori Goto; Hiroki Karube; Masahiro Sakamoto; Chang-Hong Ren; Shingo Koyama; Hikaru Nagasawa; Hideki Kimura; Toru Kawanami; Keiji Kurita; Katsushi Tajima; Makoto Daimon; Masanori Baba; Takashi Kido; Sachiko Saino; Kaoru Goto; Hironobu Asao; Chihumi Kitanaka; Emi Takashita; Seiji Hongo; Takao Nakamura; Takamasa Kayama; Yoshihiro Suzuki; Kazuo Kobayashi; Tadashi Katagiri; Katsuro Kurokawa; Masayuki Kurimura; Itaru Toyoshima; Kazuhiro Niizato; Kuniaki Tsuchiya; Takeshi Iwatsubo; Masaaki Muramatsu; Hiroto Matsumine; Takeo Kato
The role of G-protein-coupled receptor kinase 5 in pathogenesis of sporadic Parkinson's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(36):9227-38.
2006: Haruhiko Fuwa; Kenichi Hiromoto; Yasuko Takahashi; Satoshi Yokoshima; Toshiyuki Kan; Tohru Fukuyama; Takeshi Iwatsubo; Taisuke Tomita; Hideaki Natsugari
Synthesis of biotinylated photoaffinity probes based on arylsulfonamide gamma-secretase inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(16):4184-9.
2006: A-M Shiarli; R Jennings; Jing Shi; K Bailey; Yvonne Davidson; Jinzhou Tian; Eileen H Bigio; Bernardino Ghetti; Jill R Murrell; Marie-Bernadette Delisle; Suzanne S Mirra; Barbara J Crain; P Zolo; K Arima; E Iseki; S Murayama; Hans A Kretzschmar; M Neumann; Carol F Lippa; G Halliday; J Mackenzie; N Khan; Rivka Ravid; dennis dickson; Zbigniew K Wszolek; Takeshi Iwatsubo; Stuart Pickering-Brown; D M A Mann
Comparison of extent of tau pathology in patients with frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17), frontotemporal lobar degeneration with Pick bodies and early onset Alzheimer's disease.
Neuropathology and applied neurobiology 2006;32(4):374-87.
2006: Yasuko Takahashi; Haruhiko Fuwa; Akane Kaneko; Makoto Sasaki; Satoshi Yokoshima; Hifumi Koizumi; Tohru Takebe; Toshiyuki Kan; Takeshi Iwatsubo; Taisuke Tomita; Hideaki Natsugari; Tohru Fukuyama
Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates.
Bioorganic & medicinal chemistry letters 2006;16(14):3813-6.
2006: Ryoko Yamamoto; Eizo Iseki; Norio Murayama; Michiko Minegishi; Wami Marui; Takashi Togo; Omi Katsuse; Masanori Kato; Takeshi Iwatsubo; Kenji Kosaka; Heii Arai
Investigation of Lewy pathology in the visual pathway of brains of dementia with Lewy bodies.
Journal of the neurological sciences 2006;246(1-2):95-101.
2006: Cédrik Garino; Taisuke Tomita; Nicolas Pietrancosta; younes laras; Roselyne Rosas; Gaëtan Herbette; Bernard Maigret; Gilles Quéléver; Takeshi Iwatsubo; Jean-Louis Kraus
Naphthyl and coumarinyl biarylpiperazine derivatives as highly potent human beta-secretase inhibitors. Design, synthesis, and enzymatic BACE-1 and cell assays.
Journal of medicinal chemistry 2006;49(14):4275-85.
2006: Takeshi Iwatsubo; Yasuo Ihara; Ichiro Kanazawa
Alzheimer disease research in Japan: public funding.
Nature medicine 2006;12(7):778-9.
2006: Chihiro Tamaki; Sumio Ohtsuki; Takeshi Iwatsubo; Tadafumi Hashimoto; Kaoru Yamada; Chiori Yabuki; Tetsuya Terasaki
Major involvement of low-density lipoprotein receptor-related protein 1 in the clearance of plasma free amyloid beta-peptide by the liver.
Pharmaceutical research 2006;23(7):1407-16.
2006: Chihiro Sato; Takeshi Iwatsubo
Focusing on beta-amyloid: report of the 35th Annual Meeting of the Society for Neuroscience.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2006;13(2):114-6.
2006: Jinzhou Tian; Jing Shi; R Smallman; Takeshi Iwatsubo; D M A Mann
Relationships in Alzheimer's disease between the extent of Abeta deposition in cerebral blood vessel walls, as cerebral amyloid angiopathy, and the amount of cerebrovascular smooth muscle cells and collagen.
Neuropathology and applied neurobiology 2006;32(3):332-40.
2006: Faiza Bensemain; Julien Chapuis; Jinzhou Tian; Jing Shi; Uma Thaker; Corinne Lendon; Takeshi Iwatsubo; Philippe Amouyel; D M A Mann; jean-charles lambert
Association study of the Ubiquilin gene with Alzheimer's disease.
Neurobiology of disease 2006;22(3):691-3.
2006: Yuichi Morohashi; Toshiyuki Kan; Yusuke Tominari; Haruhiko Fuwa; Yumiko Okamura; Naoto Watanabe; Chihiro Sato; Hideaki Natsugari; Tohru Fukuyama; Takeshi Iwatsubo; Taisuke Tomita
C-terminal fragment of presenilin is the molecular target of a dipeptidic gamma-secretase-specific inhibitor DAPT (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester).
The Journal of biological chemistry 2006;281(21):14670-6.
2006: Masami Masuda; Nobuyuki Suzuki; Sayuri Taniguchi; Takayuki Oikawa; Takashi Nonaka; Takeshi Iwatsubo; Shin-ichi Hisanaga; Michel Goedert; Masato Hasegawa
Small molecule inhibitors of alpha-synuclein filament assembly.
Biochemistry 2006;45(19):6085-94.
2006: Toshihiko Ogura; Kazuhiro Mio; Ikuo Hayashi; Hiroyuki Miyashita; Rie Fukuda; Raphael Kopan; Tatsuhiko Kodama; Takao Hamakubo; Takeshi Iwatsubo; Takeshi Iwastubo; Taisuke Tomita; Chikara Sato
Three-dimensional structure of the gamma-secretase complex.
Biochemical and biophysical research communications 2006;343(2):525-34.
2006: Rohan de Silva; Tammaryn Lashley; Catherine Strand; Anna-Maria Shiarli; Jing Shi; Jinzhou Tian; Kathryn L Bailey; Peter Davies; Eileen H Bigio; Kunimasa Arima; Eizo Iseki; Shigeo Murayama; Hans A Kretzschmar; Manuela Neumann; Carol F Lippa; Glenda Halliday; James MacKenzie; Rivka Ravid; dennis dickson; Zbigniew K Wszolek; Takeshi Iwatsubo; Stuart Pickering-Brown; Janice Holton; Andrew J Lees; Tamas Revesz; D M A Mann
An immunohistochemical study of cases of sporadic and inherited frontotemporal lobar degeneration using 3R- and 4R-specific tau monoclonal antibodies.
Acta neuropathologica 2006;111(4):329-40.
2006: Yvonne Davidson; Linda Gibbons; Antonia Pritchard; Jayne Hardicre; Joanne Wren; Jinzhou Tian; Jing Shi; Cheryl Stopford; Camille L Julien; Jennifer Thompson; Antony Payton; Uma Thaker; A J Hayes; Takeshi Iwatsubo; Stuart Pickering-Brown; Neil Pendleton; Michael A Horan; Alistair Burns; Nitin Purandare; Corinne Lendon; David Neary; Julie S Snowden; D M A Mann
Genetic associations between cathepsin D exon 2 C-->T polymorphism and Alzheimer's disease, and pathological correlations with genotype.
Journal of neurology, neurosurgery, and psychiatry 2006;77(4):515-7.
2006: Genta Ito; Hiroyoshi Ariga; Yasuhito Nakagawa; Takeshi Iwatsubo
Roles of distinct cysteine residues in S-nitrosylation and dimerization of DJ-1.
Biochemical and biophysical research communications 2006;339(2):667-72.
2006: Tomoki Kuwahara; Akihiko Koyama; Keiko Gengyo-Ando; Mayumi Masuda; Hisanori Kowa; Makoto Tsunoda; Shohei Mitani; Takeshi Iwatsubo
Familial Parkinson mutant alpha-synuclein causes dopamine neuron dysfunction in transgenic Caenorhabditis elegans.
The Journal of biological chemistry 2006;281(1):334-40.
2006: Xiongwei Zhu; Asim Babar; Sandra L Siedlak; Qiwei Yang; Genta Ito; Takeshi Iwatsubo; Mark A. Smith; George Perry; Shu G Chen
LRRK2 in Parkinson's disease and dementia with Lewy bodies.
Molecular neurodegeneration 2006;1():17.
2006: Taisuke Tomita; Sayaka Tanaka; Yuichi Morohashi; Takeshi Iwatsubo
Presenilin-dependent intramembrane cleavage of ephrin-B1.
Molecular neurodegeneration 2006;1():2.
2006: Taisuke Tomita; Takeshi Iwatsubo
gamma-secretase as a therapeutic target for treatment of Alzheimer's disease.
Current pharmaceutical design 2006;12(6):661-70.
2006: Jing Shi; Jinzhou Tian; Antonia Pritchard; Corinne Lendon; jean-charles lambert; Takeshi Iwatsubo; D M A Mann
A 3'-UTR polymorphism in the oxidized LDL receptor 1 gene increases Abeta40 load as cerebral amyloid angiopathy in Alzheimer's disease.
Acta neuropathologica 2006;111(1):15-20.
2005: Ian G McKeith; dennis dickson; J Lowe; M Emre; John T O'Brien; H Feldman; Jeffrey L Cummings; J E Duda; Carol F Lippa; Elaine K Perry; Dag Aarsland; Heii Arai; Clive G Ballard; Bradley Boeve; David J Burn; D Costa; T Del Ser; Bruno Dubois; Douglas Galasko; S Gauthier; Christopher G Goetz; E Gomez-Tortosa; G Halliday; Lawrence A Hansen; John Hardy; Takeshi Iwatsubo; Rajesh N. Kalaria; Daniel Kaufer; R A Kenny; Amos D Korczyn; Kenji Kosaka; Virginia M-Y Lee; Andrew J Lees; I Litvan; E Londos; Oscar L Lopez; Satoshi Minoshima; Yoshikuni Mizuno; J A Molina; E B Mukaetova-Ladinska; Florence Pasquier; Robert H Perry; J B Schulz; John Q Trojanowski; Masahito Yamada
Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium.
Neurology 2005;65(12):1863-72.
2005: Naoto Watanabe; Taisuke Tomita; Chihiro Sato; Toshio Kitamura; Yuichi Morohashi; Takeshi Iwatsubo
Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1.
The Journal of biological chemistry 2005;280(51):41967-75.
2005: Toshihiro Takeda; Michio Asahi; Osamu Yamaguchi; Shungo Hikoso; Hiroyuki Nakayama; Yoichiro Kusakari; Makoto Kawai; Kenichi Hongo; Yoshiharu Higuchi; Kazunori Kashiwase; Tetsuya Watanabe; Masako Taniike; Atsuko Nakai; Kazuhiko Nishida; Satoshi Kurihara; Dorit B Donoviel; alan bernstein; Taisuke Tomita; Takeshi Iwatsubo; Masatsugu Hori; Kinya Otsu
Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(14):2069-71.
2005: Clifford W Shults; Edward Rockenstein; Leslie Crews; Anthony Adame; Michael Mante; Gabriel Larrea; Makoto Hashimoto; David Song; Takeshi Iwatsubo; Kyoko Tsuboi; Eliezer Masliah
Neurological and neurodegenerative alterations in a transgenic mouse model expressing human alpha-synuclein under oligodendrocyte promoter: implications for multiple system atrophy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(46):10689-99.
2005: Takeshi Iwatsubo; Genta Ito; Sho Takatori; Yoko Hannno; Tomoki Kuwahara
[Pathogenesis of Parkinson's disease: implications from familial Parkinson's disease].
Rinshō shinkeigaku = Clinical neurology 2005;45(11):899-901.
2005: Takeshi Iwatsubo
[Molecular pathology and therapeutic perspectives of Alzheimer's disease].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 2005;42(6):651-4.
2005: Antonia Pritchard; Judith Harris; Colin W Pritchard; David St Clair; Helen Lemmon; jean-charles lambert; Marie-Christine Chartier-Harlin; Angela Hayes; Uma Thaker; Takeshi Iwatsubo; D M A Mann; Corinne Lendon
Association study and meta-analysis of low-density lipoprotein receptor related protein in Alzheimer's disease.
Neuroscience letters 2005;382(3):221-6.
2005: jean-charles lambert; D M A Mann; F Richard; Jinzhou Tian; Jing Shi; Uma Thaker; S Merrot; Judith Harris; Bernard Frigard; Takeshi Iwatsubo; Corinne Lendon; Philippe Amouyel
Is there a relation between APOE expression and brain amyloid load in Alzheimer's disease?
Journal of neurology, neurosurgery, and psychiatry 2005;76(7):928-33.
2005: Yutaka Machida; Tomoki Chiba; Atsushi Takayanagi; Yoshikazu Tanaka; Masato Asanuma; Norio Ogawa; Akihiko Koyama; Takeshi Iwatsubo; Shosuke Ito; Poul Hening Jansen; Nobuyoshi Shimizu; Keiji Tanaka; Yoshikuni Mizuno; Nobutaka Hattori
Common anti-apoptotic roles of parkin and alpha-synuclein in human dopaminergic cells.
Biochemical and biophysical research communications 2005;332(1):233-40.
2005: Wanli Smith; Russell L Margolis; Xiaojie Li; Juan C Troncoso; Michael K Lee; Valina Dawson; Ted M Dawson; Takeshi Iwatsubo; Christopher A Ross
Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(23):5544-52.
2005: Eizo Iseki; Wami Marui; Ryoko Yamamoto; Takashi Togo; Omi Katsuse; Masanori Kato; Takeshi Iwatsubo; Kenji Kosaka; Heii Arai
The nigro-striatal and nigro-amygdaloid pathways undergo different degeneration processes in brains of dementia with Lewy bodies.
Neuroscience letters 2005;380(1-2):161-5.
2005: Yasuomi Urano; Ikuo Hayashi; Noriko Isoo; Patrick C Reid; Yoshikazu Shibasaki; Noriko Noguchi; Taisuke Tomita; Takeshi Iwatsubo; Takao Hamakubo; Tatsuhiko Kodama
Association of active gamma-secretase complex with lipid rafts.
Journal of lipid research 2005;46(5):904-12.
2005: Manabu Niimura; Noriko Isoo; Nobumasa Takasugi; Makiko Tsuruoka; Kumiko Ui-Tei; Kaoru Saigo; Yuichi Morohashi; Taisuke Tomita; Takeshi Iwatsubo
Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions.
The Journal of biological chemistry 2005;280(13):12967-75.
2005: Yoshihide Osada; Tadafumi Hashimoto; Akiko Nishimura; Yuko Matsuo; Tomoko Wakabayashi; Takeshi Iwatsubo
CLAC binds to amyloid beta peptides through the positively charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils.
The Journal of biological chemistry 2005;280(9):8596-605.
2005: Sayuri Taniguchi; Nobuyuki Suzuki; Masami Masuda; Shin-ichi Hisanaga; Takeshi Iwatsubo; Michel Goedert; Masato Hasegawa
Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins.
The Journal of biological chemistry 2005;280(9):7614-23.
2005: Takashi Nonaka; Takeshi Iwatsubo; Masato Hasegawa
Ubiquitination of alpha-synuclein.
Biochemistry 2005;44(1):361-8.
2004: Christophe Lo Bianco; Bernard L Schneider; Matthias Bauer; Ali Sajadi; Alexis Brice; Takeshi Iwatsubo; Patrick Aebischer
Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(50):17510-5.
2004: Takeshi Iwatsubo
[Pathogenesis of Alzheimer's disease: implications from amyloid research front].
Rinshō shinkeigaku = Clinical neurology 2004;44(11):768-70.
2004: Hisanori Kowa; Takeshi Iwatsubo
[Amyloid beta peptide].
Nihon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 11():307-9.
2004: Masanori Yamada; Takeshi Iwatsubo; Yoshikuni Mizuno; Hideki Mochizuki
Overexpression of alpha-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of alpha-synuclein and activation of caspase-9: resemblance to pathogenetic changes in Parkinson's disease.
Journal of neurochemistry 2004;91(2):451-61.
2004: Ikuo Hayashi; Yasuomi Urano; Ryouichi Fukuda; Noriko Isoo; Tatsuhiko Kodama; Takao Hamakubo; Taisuke Tomita; Takeshi Iwatsubo
Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles.
The Journal of biological chemistry 2004;279(36):38040-6.
2004: Takashi Nonaka; Takeshi Iwatsubo; Masato Hasegawa
[Analysis of alpha-synuclein and its significance].
Nihon rinsho. Japanese journal of clinical medicine 2004;62(9):1623-8.
2004: Yu Hirai; Shinobu C Fujita; Takeshi Iwatsubo; Masato Hasegawa
Phosphorylated alpha-synuclein in normal mouse brain.
FEBS letters 2004;572(1-3):227-32.
2004: Taisuke Tomita; Takeshi Iwatsubo
[Recent advances in Alzheimer's disease-related gamma-secretase complex].
Seikagaku. The Journal of Japanese Biochemical Society 2004;76(7):666-70.
2004: Hisanori Kowa; Tomoko Sakakura; Yusuke Matsuura; Tomoko Wakabayashi; D M A Mann; karen duff; Shoji Tsuji; Tadafumi Hashimoto; Takeshi Iwatsubo
Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits.
The American journal of pathology 2004;165(1):273-81.
2004: Yosuke Wakutani; K Watanabe; Yoshiki Adachi; Kenji Wada-Isoe; Katsuya Urakami; H Ninomiya; Takaomi C Saido; T Hashimoto; Takeshi Iwatsubo; Kenji Nakashima
Novel amyloid precursor protein gene missense mutation (D678N) in probable familial Alzheimer's disease.
Journal of neurology, neurosurgery, and psychiatry 2004;75(7):1039-42.
2004: Osamu Nagano; Daizo Murakami; Dieter Hartmann; Bart De Strooper; Paul Saftig; Takeshi Iwatsubo; Motowo Nakajima; Masanori Shinohara; Hideyuki Saya
Cell-matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca(2+) influx and PKC activation.
The Journal of cell biology 2004;165(6):893-902.
2004: Taisuke Tomita; Takeshi Iwatsubo
The inhibition of gamma-secretase as a therapeutic approach to Alzheimer's disease.
Drug news & perspectives 2004;17(5):321-5.
2004: Takeshi Iwatsubo
The gamma-secretase complex: machinery for intramembrane proteolysis.
Current opinion in neurobiology 2004;14(3):379-83.
2004: Yong Zhang; Angela Hayes; Antonia Pritchard; Uma Thaker; M Sayeed Haque; Helen Lemmon; Judith Harris; Alistair Cumming; jean-charles lambert; Marie-Christine Chartier-Harlin; David St Clair; Takeshi Iwatsubo; D M A Mann; Corinne Lendon
Interleukin-6 promoter polymorphism: risk and pathology of Alzheimer's disease.
Neuroscience letters 2004;362(2):99-102.
2004: Takeshi Iwatsubo
[Alzheimer's disease: focus on beta-amyloid and gamma-secretase].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2004;49(7 Suppl):1086-90.
2004: Masaoki Kawasumi; Tomohiro Chiba; Marina Yamada; Makiko Miyamae-Kaneko; Masaaki Matsuoka; Jin Nakahara; Taisuke Tomita; Takeshi Iwatsubo; Shigeaki Kato; Sadakazu Aiso; Ikuo Nishimoto; Keisuke Kouyama
Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer's disease in aged mice.
The European journal of neuroscience 2004;19(10):2826-38.
2004: Toshiyuki Kan; Yusuke Tominari; Kentaro Rikimaru; Yuichi Morohashi; Hideaki Natsugari; Taisuke Tomita; Takeshi Iwatsubo; Tohru Fukuyama
Parallel synthesis of DAPT derivatives and their gamma-secretase-inhibitory activity.
Bioorganic & medicinal chemistry letters 2004;14(8):1983-5.
2004: Yuri Umeda; Sayuri Taniguchi; Kunimasa Arima; Yue-Shan Piao; Hitoshi Takahashi; Takeshi Iwatsubo; D M A Mann; Masato Hasegawa
Alterations in human tau transcripts correlate with those of neurofilament in sporadic tauopathies.
Neuroscience letters 2004;359(3):151-4.
2004: Makoto Nishie; Fumiaki Mori; Hideo Fujiwara; Masato Hasegawa; Makoto Yoshimoto; Takeshi Iwatsubo; Hitoshi Takahashi; Koichi Wakabayashi
Accumulation of phosphorylated alpha-synuclein in the brain and peripheral ganglia of patients with multiple system atrophy.
Acta neuropathologica 2004;107(4):292-8.
2004: Hiroko Matsubayashi; Sonoka Sese; Jong-Seo Lee; Tadaoki Shirakawa; Takeshi Iwatsubo; Taisuke Tomita; Shin-ichi Yanagawa
Biochemical characterization of the Drosophila wingless signaling pathway based on RNA interference.
Molecular and cellular biology 2004;24(5):2012-24.
2004: jean-charles lambert; D M A Mann; J Harris; L Araria-Goumidi; Marie-Christine Chartier-Harlin; D Cottel; Takeshi Iwatsubo; Philippe Amouyel; Corinne Lendon
Association study of Notch 4 polymorphisms with Alzheimer's disease.
Journal of neurology, neurosurgery, and psychiatry 2004;75(3):377-81.
2004: Mikiei Tanaka; Yong Man Kim; Gwang Lee; Eunsung Junn; Takeshi Iwatsubo; M Maral Mouradian
Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective.
The Journal of biological chemistry 2004;279(6):4625-31.
2004: S Taniguchi; AM McDonagh; Stuart Pickering-Brown; Y Umeda; Takeshi Iwatsubo; M Hasegawa; D M A Mann
The neuropathology of frontotemporal lobar degeneration with respect to the cytological and biochemical characteristics of tau protein.
Neuropathology and applied neurobiology 2004;30(1):1-18.
2004: Victoria Busby; Steven Goossens; Petra Nowotny; Gillian Hamilton; Scott Smemo; Denise Harold; Dragana Turic; Luke Jehu; Amanda Myers; Meredith Womick; Daniel Woo; Danielle Compton; Lisa M Doil; Kristina M Tacey; Kit F Lau; Safa Al-Saraj; Richard Killick; Stuart Pickering-Brown; Pamela Moore; Paul Hollingworth; Nicola Archer; Catherine Foy; Sarah Walter; Corrine Lendon; Takeshi Iwatsubo; John C Morris; Joanne Norton; D M A Mann; Barbara Janssens; John Hardy; Michael O'Donovan; Lesley Jones; Julie Williams; Peter Holmans; Michael J Owen; Andrew Grupe; John Powell; Jolanda van Hengel; Alison Goate; Frans Van Roy; Simon Lovestone
Alpha-T-catenin is expressed in human brain and interacts with the Wnt signaling pathway but is not responsible for linkage to chromosome 10 in Alzheimer's disease.
Neuromolecular medicine 2004;5(2):133-46.
2004: Takeshi Iwatsubo
Assembly and activation of the gamma-secretase complex: roles of presenilin cofactors.
Molecular psychiatry 2004;9(1):8-10.
2003: Linda Söderberg; Victoria Zhukareva; Nenad Bogdanovic; Tadafumi Hashimoto; Bengt Winblad; Takeshi Iwatsubo; Virginia M-Y Lee; John Q Trojanowski; Jan Näslund
Molecular identification of AMY, an Alzheimer disease amyloid-associated protein.
Journal of neuropathology and experimental neurology 2003;62(11):1108-17.
2003: Eric H Schroeter; Ma Xenia G Ilagan; Anne L Brunkan; Silva Hecimovic; Yueming Li; Min Xu; Huw D Lewis; Meera T Saxena; Bart De Strooper; Archie Coonrod; Taisuke Tomita; Takeshi Iwatsubo; Chad L Moore; Alison Goate; Michael S Wolfe; Mark S Shearman; Raphael Kopan
A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(22):13075-80.
2003: Takeshi Iwatsubo
Aggregation of alpha-synuclein in the pathogenesis of Parkinson's disease.
Journal of neurology 2003;250 Suppl 3():III11-4.
2003: Yoichiro Abe; Keisuke Kouyama; Taisuke Tomita; Yusuke Tomita; Norimitsu Ban; Mikiro Nawa; Masaaki Matsuoka; Takako Niikura; Sadakazu Aiso; Yoshiko Kita; Takeshi Iwatsubo; Ikuo Nishimoto
Analysis of neurons created from wild-type and Alzheimer's mutation knock-in embryonic stem cells by a highly efficient differentiation protocol.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(24):8513-25.
2003: Toshiyuki Kan; Yusuke Tominari; Yuichi Morohashi; Hideaki Natsugari; Taisuke Tomita; Takeshi Iwatsubo; Tohru Fukuyama
Solid-phase synthesis of photoaffinity probes: highly efficient incorporation of biotin-tag and cross-linking groups.
Chemical communications (Cambridge, England) 2003;(17):2244-5.
2003: Fumiaki Mori; Yue-Shan Piao; Shintaro Hayashi; Hideo Fujiwara; Masato Hasegawa; Makoto Yoshimoto; Takeshi Iwatsubo; Hitoshi Takahashi; Koichi Wakabayashi
Alpha-synuclein accumulates in Purkinje cells in Lewy body disease but not in multiple system atrophy.
Journal of neuropathology and experimental neurology 2003;62(8):812-9.
2003: Yuko Saito; Akiko Kawashima; Nyoka N Ruberu; Hideo Fujiwara; Shunichi Koyama; Motoji Sawabe; Tomio Arai; Hiroshi Nagura; Hiroshi Yamanouchi; Masato Hasegawa; Takeshi Iwatsubo; Shigeo Murayama
Accumulation of phosphorylated alpha-synuclein in aging human brain.
Journal of neuropathology and experimental neurology 2003;62(6):644-54.
2003: jean-charles lambert; Erin Luedecking-Zimmer; S Merrot; A Hayes; Uma Thaker; P Desai; A Houzet; Xavier Hermant; Dominique Cottel; Antonia Pritchard; Takeshi Iwatsubo; Florence Pasquier; Bernard Frigard; P M Conneally; Marie-Christine Chartier-Harlin; Steven T DeKosky; Corinne Lendon; D M A Mann; M Ilyas Kamboh; Philippe Amouyel
Association of 3'-UTR polymorphisms of the oxidised LDL receptor 1 (OLR1) gene with Alzheimer's disease.
Journal of medical genetics 2003;40(6):424-30.
2003: Yasuko Takahashi; Ikuo Hayashi; Yusuke Tominari; Kentaro Rikimaru; Yuichi Morohashi; Toshiyuki Kan; Hideaki Natsugari; Tohru Fukuyama; Taisuke Tomita; Takeshi Iwatsubo
Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation.
The Journal of biological chemistry 2003;278(20):18664-70.
2003: Flavio Kamenetz; Taisuke Tomita; Helen Hsieh; Guy Seabrook; David R Borchelt; Takeshi Iwatsubo; Sangram S Sisodia; Roberto Malinow
APP processing and synaptic function.
Neuron 2003;37(6):925-37.
2003: Nobumasa Takasugi; Taisuke Tomita; Ikuo Hayashi; Makiko Tsuruoka; Manabu Niimura; Yasuko Takahashi; Gopal Thinakaran; Takeshi Iwatsubo
The role of presenilin cofactors in the gamma-secretase complex.
Nature 2003;422(6930):438-41.
2003: Daizo Murakami; Isamu Okamoto; Osamu Nagano; Yoshiaki Kawano; Taisuke Tomita; Takeshi Iwatsubo; Bart De Strooper; Eiji Yumoto; Hideyuki Saya
Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44.
Oncogene 2003;22(10):1511-6.
2003: Takeshi Iwatsubo
Molecular pathogenesis of Alzheimer's disease.
Internal medicine (Tokyo, Japan) 2003;42(3):312.
2003: Uma Thaker; AM McDonagh; Takeshi Iwatsubo; Corinne Lendon; Stuart Pickering-Brown; D M A Mann
Tau load is associated with apolipoprotein E genotype and the amount of amyloid beta protein, Abeta40, in sporadic and familial Alzheimer's disease.
Neuropathology and applied neurobiology 2003;29(1):35-44.
2003: Makio Takahashi; Hirotaka Kanuka; Hideo Fujiwara; Akihiko Koyama; Masato Hasegawa; Masayuki Miura; Takeshi Iwatsubo
Phosphorylation of alpha-synuclein characteristic of synucleinopathy lesions is recapitulated in alpha-synuclein transgenic Drosophila.
Neuroscience letters 2003;336(3):155-8.
2002: Nobumasa Takasugi; Yasuko Takahashi; Yuichi Morohashi; Taisuke Tomita; Takeshi Iwatsubo
The mechanism of gamma-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals.
The Journal of biological chemistry 2002;277(51):50198-205.
2002: Masato Hasegawa; Hideo Fujiwara; Takashi Nonaka; Koichi Wakabayashi; Hitoshi Takahashi; Virginia M-Y Lee; John Q Trojanowski; D M A Mann; Takeshi Iwatsubo
Phosphorylated alpha-synuclein is ubiquitinated in alpha-synucleinopathy lesions.
The Journal of biological chemistry 2002;277(50):49071-6.
2002: Takeshi Iwatsubo
[The mechanism of A beta production and its inhibition as a therapeutic strategy for the prevention of Alzheimer's disease].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2002;120(1):30P-33P.
2002: Manuela Neumann; Philipp J Kahle; Benoit I Giasson; Laurence Ozmen; Edilio Borroni; Will Spooren; Veronika Müller; Sabine Odoy; Hideo Fujiwara; Masato Hasegawa; Takeshi Iwatsubo; John Q Trojanowski; Hans A Kretzschmar; Christian Haass
Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies.
The Journal of clinical investigation 2002;110(10):1429-39.
2002: Sachio Matsushita; Hiroyuki Arai; Nobuyuki Okamura; Tomohiro Ohmori; Keiichi Takasugi; Toshifumi Matsui; Masahiro Maruyama; Takeshi Iwatsubo; Susumu Higuchi
Clinical and biomarker investigation of a patient with a novel presenilin-1 mutation (A431V) in the mild cognitive impairment stage of Alzheimer's disease.
Biological psychiatry 2002;52(9):907-10.
2002: Angela Hayes; Uma Thaker; Takeshi Iwatsubo; Stuart Pickering-Brown; D M A Mann
Pathological relationships between microglial cell activity and tau and amyloid beta protein in patients with Alzheimer's disease.
Neuroscience letters 2002;331(3):171-4.
2002: Tomomi Watanabe; Kentaro Nakagawa; Shinya Ohata; Daiju Kitagawa; Gen Nishitai; Jungwon Seo; Shuhei Tanemura; Nao Shimizu; Hiroyuki Kishimoto; Teiji Wada; Junken Aoki; Hiroyuki Arai; Takeshi Iwatsubo; Miyuki Mochita; Toshio Watanabe; Masanobu Satake; Yoshiaki Ito; Toshifumi Matsuyama; Tak W Mak; Josef M Penninger; Hiroshi Nishina; Toshiaki Katada
SEK1/MKK4-mediated SAPK/JNK signaling participates in embryonic hepatoblast proliferation via a pathway different from NF-kappaB-induced anti-apoptosis.
Developmental biology 2002;250(2):332-47.
2002: Masayasu Okochi; Harald Steiner; Akio Fukumori; Hisashi Tanii; Taisuke Tomita; Toshihisa Tanaka; Takeshi Iwatsubo; Takashi Kudo; Masatoshi Takeda; Christian Haass
Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.
The EMBO journal 2002;21(20):5408-16.
2002: Jae Yoon Leem; Carlos A Saura; Claus U Pietrzik; John C Christianson; Christian P Wanamaker; LaShaunda T King; Margaret L Veselits; Taisuke Tomita; Laura Gasparini; Takeshi Iwatsubo; Huaxi Xu; William N Green; Edward H Koo; Gopal Thinakaran
A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface.
Neurobiology of disease 2002;11(1):64-82.
2002: Takeshi Iwatsubo
[Molecular mechanism of Alzheimer disease].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2002;91 Suppl():149-51.
2002: Shinji Ohara; Jun Tsuyuzaki; Takashi Oide; Hiroyuki Arai; Susumu Higuchi; Masato Hasegawa; Takeshi Iwatsubo
A clinical and neuropathological study of an unusual case of sporadic tauopathy. A variant of corticobasal degeneration?
Neuroscience letters 2002;330(1):84-8.
2002: Corinne Lendon; Uma Thaker; JM Harris; AM McDonagh; jean-charles lambert; Marie-Christine Chartier-Harlin; Takeshi Iwatsubo; Stuart Pickering-Brown; D M A Mann
The angiotensin 1-converting enzyme insertion (I)/deletion (D) polymorphism does not influence the extent of amyloid or tau pathology in patients with sporadic Alzheimer's disease.
Neuroscience letters 2002;328(3):314-8.
2002: L Araria-Goumidi; jean-charles lambert; D M A Mann; Corinne Lendon; Bernard Frigard; Takeshi Iwatsubo; D Cottel; Philippe Amouyel; Marie-Christine Chartier-Harlin
Association study of three polymorphisms of TGF-beta1 gene with Alzheimer's disease.
Journal of neurology, neurosurgery, and psychiatry 2002;73(1):62-4.
2002: Noriko Hazeki; Tadashi Tsukamoto; Ikuru Yazawa; Minami Koyama; hattori shunji; Iori Someki; Takeshi Iwatsubo; Koichiro Nakamura; Jun Goto; Ichiro Kanazawa
Ultrastructure of nuclear aggregates formed by expressing an expanded polyglutamine.
Biochemical and biophysical research communications 2002;294(2):429-40.
2002: Taisuke Tomita; Ryohei Katayama; Rie Takikawa; Takeshi Iwatsubo
Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments.
FEBS letters 2002;520(1-3):117-21.
2002: Takeshi Iwatsubo
[alpha-synuclein and Parkinson's disease].
Seikagaku. The Journal of Japanese Biochemical Society 2002;74(6):477-82.
2002: Philipp J Kahle; Manuela Neumann; Laurence Ozmen; Veronika Muller; Helmut Jacobsen; Will Spooren; Babette Fuss; Barbara S Mallon; Wendy B Macklin; Hideo Fujiwara; Masato Hasegawa; Takeshi Iwatsubo; Hans A Kretzschmar; Christian Haass
Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes.
EMBO reports 2002;3(6):583-8.
2002: Elaine K Green; JM Harris; Helen Lemmon; jean-charles lambert; Marie-Christine Chartier-Harlin; D St Clair; D M A Mann; Takeshi Iwatsubo; Corinne Lendon
Are interleukin-1 gene polymorphisms risk factors or disease modifiers in AD?
Neurology 2002;58(10):1566-8.
2002: Hirotomo Miake; Hidehiro Mizusawa; Takeshi Iwatsubo; Masato Hasegawa
Biochemical characterization of the core structure of alpha-synuclein filaments.
The Journal of biological chemistry 2002;277(21):19213-9.
2002: Elaine K Green; Uma Thaker; AM McDonagh; Takeshi Iwatsubo; jean-charles lambert; Marie-Christine Chartier-Harlin; JM Harris; Stuart Pickering-Brown; Corinne Lendon; D M A Mann
A polymorphism within intron 11 of the tau gene is not increased in frequency in patients with sporadic Alzheimer's disease, nor does it influence the extent of tau pathology in the brain.
Neuroscience letters 2002;324(2):113-6.
2002: Yuichi Morohashi; Noriyuki Hatano; Susumu Ohya; Rie Takikawa; Tomonari Watabiki; Nobumasa Takasugi; Yuji Imaizumi; Taisuke Tomita; Takeshi Iwatsubo
Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4.
The Journal of biological chemistry 2002;277(17):14965-75.
2002: Tadafumi Hashimoto; Tomoko Wakabayashi; Atsushi Watanabe; Hisanori Kowa; Ritsuko Hosoda; Atsushi Nakamura; Ichiro Kanazawa; Takao Arai; Koji Takio; D M A Mann; Takeshi Iwatsubo
CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV.
The EMBO journal 2002;21(7):1524-34.
2002: Shintaro Hayashi; Yasuko Toyoshima; Masato Hasegawa; Yuri Umeda; Koichi Wakabayashi; Susumu Tokiguchi; Takeshi Iwatsubo; Hitoshi Takahashi
Late-onset frontotemporal dementia with a novel exon 1 (Arg5His) tau gene mutation.
Annals of neurology 2002;51(4):525-30.
2002: Hideo Fujiwara; Masato Hasegawa; Naoshi Dohmae; Akiko Kawashima; Eliezer Masliah; Matthew S Goldberg; Jie Shen; Koji Takio; Takeshi Iwatsubo
alpha-Synuclein is phosphorylated in synucleinopathy lesions.
Nature cell biology 2002;4(2):160-4.
2001: Takeshi Iwatsubo
[Beta-amyloid protein: recent progress in basic research and therapeutic approaches].
Rinshō shinkeigaku = Clinical neurology 2001;41(12):1198-200.
2001: Philipp J Kahle; Manuela Neumann; Laurence Ozmen; Veronika Müller; Sabine Odoy; N Okamoto; Helmut Jacobsen; Takeshi Iwatsubo; John Q Trojanowski; H Takahashi; K Wakabayashi; Nenad Bogdanovic; Peter Riederer; Hans A Kretzschmar; Christian Haass
Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model.
The American journal of pathology 2001;159(6):2215-25.
2001: Yuji Ikegaya; J A Kim; M Baba; Takeshi Iwatsubo; N Nishiyama; Norio Matsuki
Rapid and reversible changes in dendrite morphology and synaptic efficacy following NMDA receptor activation: implication for a cellular defense against excitotoxicity.
Journal of cell science 2001;114(Pt 22):4083-93.
2001: Taisuke Tomita; T Watabiki; Rie Takikawa; Yuichi Morohashi; Nobumasa Takasugi; R Kopan; Bart De Strooper; Takeshi Iwatsubo
The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins.
The Journal of biological chemistry 2001;276(35):33273-81.
2001: Hideo Mori; Yumiko Motoi; Tomonori Kobayashi; Masato Hasegawa; A Yamamura; Takeshi Iwatsubo; Yoshikuni Mizuno
Tau accumulation in a patient with pallidonigroluysian atrophy.
Neuroscience letters 2001;309(2):89-92.
2001: H Iwata; Taisuke Tomita; Kei Maruyama; Takeshi Iwatsubo
Subcellular compartment and molecular subdomain of beta-amyloid precursor protein relevant to the Abeta 42-promoting effects of Alzheimer mutant presenilin 2.
The Journal of biological chemistry 2001;276(24):21678-85.
2001: Keiro Shirotani; Satoshi Tsubuki; Nobuhisa Iwata; Yoshie Takaki; W Harigaya; K Maruyama; S Kiryu-Seo; H Kiyama; H Iwata; Taisuke Tomita; Takeshi Iwatsubo; Takaomi C Saido
Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases.
The Journal of biological chemistry 2001;276(24):21895-901.
2001: D M A Mann; A Takeuchi; S Sato; Nigel J Cairns; P L Lantos; Martin N Rossor; M Haltia; Hannu Kalimo; Takeshi Iwatsubo
Cases of Alzheimer's disease due to deletion of exon 9 of the presenilin-1 gene show an unusual but characteristic beta-amyloid pathology known as 'cotton wool' plaques.
Neuropathology and applied neurobiology 2001;27(3):189-96.
2001: D M A Mann; Stuart Pickering-Brown; A Takeuchi; Takeshi Iwatsubo
Amyloid angiopathy and variability in amyloid beta deposition is determined by mutation position in presenilin-1-linked Alzheimer's disease.
The American journal of pathology 2001;158(6):2165-75.
2001: jean-charles lambert; D M A Mann; JM Harris; Marie-Christine Chartier-Harlin; Alistair Cumming; J Coates; Helen Lemmon; D StClair; Takeshi Iwatsubo; Corinne Lendon
The -48 C/T polymorphism in the presenilin 1 promoter is associated with an increased risk of developing Alzheimer's disease and an increased Abeta load in brain.
Journal of medical genetics 2001;38(6):353-5.
2001: D M A Mann; AM McDonagh; Stuart Pickering-Brown; H Kowa; Takeshi Iwatsubo
Amyloid beta protein deposition in patients with frontotemporal lobar degeneration: relationship to age and apolipoprotein E genotype.
Neuroscience letters 2001;304(3):161-4.
2001: Auli Verkkoniemi; Hannu Kalimo; Anders Paetau; Mirja Somer; Takeshi Iwatsubo; John Hardy; Matti Haltia
Variant Alzheimer disease with spastic paraparesis: neuropathological phenotype.
Journal of neuropathology and experimental neurology 2001;60(5):483-92.
2001: Shigeki Kuzuhara; Yasumasa Kokubo; R Sasaki; Y Narita; Tadashi Yabana; M Hasegawa; Takeshi Iwatsubo
Familial amyotrophic lateral sclerosis and parkinsonism-dementia complex of the Kii Peninsula of Japan: clinical and neuropathological study and tau analysis.
Annals of neurology 2001;49(4):501-11.
2001: Susumu Ohya; Y Morohashi; Katsuhiko Muraki; Taisuke Tomita; Minoru Watanabe; Takeshi Iwatsubo; Yuji Imaizumi
Molecular cloning and expression of the novel splice variants of K(+) channel-interacting protein 2.
Biochemical and biophysical research communications 2001;282(1):96-102.
2001: N Hirota; Kousei Ito; Takeshi Iwatsubo; Carol E Green; Charles A Tyson; N Shimada; Hiroshi Suzuki; Yuichi Sugiyama
In vitro/in vivo scaling of alprazolam metabolism by CYP3A4 and CYP3A5 in humans.
Biopharmaceutics & drug disposition 2001;22(2):53-71.
2001: Yue-Shan Piao; Shintaro Hayashi; Masato Hasegawa; Koichi Wakabayashi; Mitsunori Yamada; Makoto Yoshimoto; A Ishikawa; Takeshi Iwatsubo; Hitoshi Takahashi
Co-localization of alpha-synuclein and phosphorylated tau in neuronal and glial cytoplasmic inclusions in a patient with multiple system atrophy of long duration.
Acta neuropathologica 2001;101(3):285-93.
2001: jean-charles lambert; D M A Mann; L Goumidi; J Harris; Philippe Amouyel; Takeshi Iwatsubo; Corinne Lendon; Marie-Christine Chartier-Harlin
Effect of the APOE promoter polymorphisms on cerebral amyloid peptide deposition in Alzheimer's disease.
Lancet 2001;357(9256):608-9.
2001: S Taniguchi; Y Fujita; S Hayashi; A Kakita; Hidenori Takahashi; S Murayama; Takaomi C Saido; S Hisanaga; Takeshi Iwatsubo; M Hasegawa
Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains.
FEBS letters 2001;489(1):46-50.
2001: JA Lee; Zhiqun Long; Noriyuki Nimura; Takeshi Iwatsubo; Kohzoh Imai; Hiroshi Homma
Localization, transport, and uptake of D-aspartate in the rat adrenal and pituitary glands.
Archives of biochemistry and biophysics 2001;385(2):242-9.
2000: Takeshi Iwatsubo
[beta-amyloid cascade: current status and future directions].
Rinshō shinkeigaku = Clinical neurology 2000;40(12):1228-30.
2000: Stuart Pickering-Brown; Matt Baker; Shu-Hui C. Yen; W K Liu; M Hasegawa; Nigel J Cairns; P L Lantos; Martin N Rossor; Takeshi Iwatsubo; Y Davies; David Allsop; R Furlong; F Owen; John Hardy; D M A Mann; Michael Hutton
Pick's disease is associated with mutations in the tau gene.
Annals of neurology 2000;48(6):859-67.
2000: Masaaki Takahashi; Sylvain Dore; Christopher D Ferris; Taisuke Tomita; Akira Sawa; H Wolosker; David R Borchelt; Takeshi Iwatsubo; Seong-Hun Kim; Gopal Thinakaran; Sangram S Sisodia; Solomon H Snyder
Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimer's disease.
Neuron 2000;28(2):461-73.
2000: jean-charles lambert; D M A Mann; L Goumidi; Judith Harris; Florence Pasquier; Bernard Frigard; Dominique Cottel; Corinne Lendon; Takeshi Iwatsubo; Philippe Amouyel; Marie-Christine Chartier-Harlin
A FE65 polymorphism associated with risk of developing sporadic late-onset alzheimer's disease but not with Abeta loading in brains.
Neuroscience letters 2000;293(1):29-32.
2000: K Wakabayashi; Y Shibasaki; M Hasegawa; Y Horikawa; Y Soma; S Hayashi; T Morita; Takeshi Iwatsubo; H Takahashi
Primary progressive aphasia with focal glial tauopathy.
Neuropathology and applied neurobiology 2000;26(5):477-81.
2000: Mineo Yamazaki; Y Arai; M Baba; Takeshi Iwatsubo; Osamu Mori; Yasuo Katayama; Kiyomitsu Oyanagi
Alpha-synuclein inclusions in amygdala in the brains of patients with the parkinsonism-dementia complex of Guam.
Journal of neuropathology and experimental neurology 2000;59(7):585-91.
2000: A Takeuchi; Michael C Irizarry; karen duff; Takaomi C Saido; Karen K. Hsiao Ashe; M Hasegawa; D M A Mann; Bradley T Hyman; Takeshi Iwatsubo
Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss.
The American journal of pathology 2000;157(1):331-9.
2000: Carlos A Saura; Taisuke Tomita; Salvador Soriano; M Takahashi; Jae Yoon Leem; T Honda; Edward H Koo; Takeshi Iwatsubo; Gopal Thinakaran
The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced abeta 42 production mediated by familial early onset Alzheimer's disease-linked PS variants.
The Journal of biological chemistry 2000;275(22):17136-42.
2000: Kunimasa Arima; A Kowalska; M Hasegawa; M Mukoyama; R Watanabe; M Kawai; K Takahashi; Takeshi Iwatsubo; Takeshi Tabira; N Sunohara
Two brothers with frontotemporal dementia and parkinsonism with an N279K mutation of the tau gene.
Neurology 2000;54(9):1787-95.
2000: T Nishizawa; Taku Nagao; Takeshi Iwatsubo; JG Forte; Tetsuro Urushidani
Molecular cloning and characterization of a novel chloride intracellular channel-related protein, parchorin, expressed in water-secreting cells.
The Journal of biological chemistry 2000;275(15):11164-73.
2000: Minoru Yasuda; J Takamatsu; Ian D'Souza; R A Crowther; Toshio Kawamata; M Hasegawa; Hiroshi Hasegawa; Maria Grazia Spillantini; Satoshi Tanimukai; Parvoneh Poorkaj-Navas; test testing; G Varani; Takeshi Iwatsubo; Michel Goedert; D G Schellenberg; Chikako Tanaka
A novel mutation at position +12 in the intron following exon 10 of the tau gene in familial frontotemporal dementia (FTD-Kumamoto)
Annals of neurology 2000;47(4):422-9.
2000: Takeshi Iwatsubo
[Alzheimer's disease: basic aspects].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 2000;37(3):207-11.
2000: K Maruyama; Mihoko Usami; Fuyuki Kametani; Taisuke Tomita; Takeshi Iwatsubo; Takaomi C Saido; Hiroshi Mori; S Ishiura
Molecular interactions between presenilin and calpain: inhibition of m-calpain protease activity by presenilin-1, 2 and cleavage of presenilin-1 by m-, mu-calpain.
International journal of molecular medicine 2000;5(3):269-73.
2000: Koichi Wakabayashi; T Fukushima; R Koide; Y Horikawa; M Hasegawa; Y Watanabe; T Noda; I Eguchi; T Morita; M Yoshimoto; Takeshi Iwatsubo; Hidenobu Takahashi
Juvenile-onset generalized neuroaxonal dystrophy (Hallervorden-Spatz disease) with diffuse neurofibrillary and lewy body pathology.
Acta neuropathologica 2000;99(3):331-6.
2000: Masayasu Okochi; Jochen Walter; A Koyama; S Nakajo; M Baba; Takeshi Iwatsubo; L Meijer; Philipp J Kahle; Christian Haass
Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein.
The Journal of biological chemistry 2000;275(1):390-7.
1999: Taisuke Tomita; Rie Takikawa; A Koyama; Yuichi Morohashi; Nobumasa Takasugi; Takaomi C Saido; Kei Maruyama; Takeshi Iwatsubo
C terminus of presenilin is required for overproduction of amyloidogenic Abeta42 through stabilization and endoproteolysis of presenilin.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(24):10627-34.
1999: Takeshi Iwatsubo
[Parkinson's disease, dementia with Lewy bodies, multiple system atrophy and alpha-synuclein].
Rinshō shinkeigaku = Clinical neurology 1999;39(12):1285-6.
1999: Taisuke Tomita; Takeshi Iwatsubo
[Molecular cell biology of presenilins].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 1999;114(6):337-46.
1999: N Okamura; Hiroyuki Arai; M Higuchi; M Tashiro; Toshifumi Matsui; M Itoh; Takeshi Iwatsubo; Taisuke Tomita; Hidetada Sasaki
Cerebrospinal fluid levels of amyloid beta-peptide1-42, but not tau have positive correlation with brain glucose metabolism in humans.
Neuroscience letters 1999;273(3):203-7.
1999: Harald Steiner; karen duff; Anja Capell; H Romig; MG Grim; Sarah J Lincoln; John Hardy; X Yu; M Picciano; K Fechteler; Martin Citron; R Kopan; B Pesold; S Keck; Miriam Baader; Taisuke Tomita; Takeshi Iwatsubo; Ralf Baumeister; Christian Haass
A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling.
The Journal of biological chemistry 1999;274(40):28669-73.
1999: H Fukumoto; Taisuke Tomita; H Matsunaga; Y Ishibashi; Takaomi C Saido; Takeshi Iwatsubo
Primary cultures of neuronal and non-neuronal rat brain cells secrete similar proportions of amyloid beta peptides ending at A beta40 and A beta42.
Neuroreport 1999;10(14):2965-9.
1999: JA Lee; Hiroshi Homma; K Tashiro; Takeshi Iwatsubo; Kohzoh Imai
D-aspartate localization in the rat pituitary gland and retina.
Brain research 1999;838(1-2):193-9.
1999: Eileen McGowan; S Sanders; Takeshi Iwatsubo; A Takeuchi; Takaomi C Saido; Cynthia Zehr; X Yu; Sacha N Uljon; Rong Wang; D M A Mann; dennis dickson; karen duff
Amyloid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes.
Neurobiology of disease 1999;6(4):231-44.
1999: Kazutoshi Nishiyama; Bruce D Trapp; T Ikezu; Richard M Ransohoff; Taisuke Tomita; Takeshi Iwatsubo; I Kanazawa; Karen K. Hsiao Ashe; Michael P Lisanti; T Okamoto
Caveolin-3 upregulation activates beta-secretase-mediated cleavage of the amyloid precursor protein in Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(15):6538-48.
1999: Ross Jakes; R Anthony Crowther; Virginia M-Y Lee; John Q Trojanowski; Takeshi Iwatsubo; Michel Goedert
Epitope mapping of LB509, a monoclonal antibody directed against human alpha-synuclein.
Neuroscience letters 1999;269(1):13-6.
1999: Takeshi Iwatsubo
[alpha-Synuclein and familial Parkinson's disease].
Nō to shinkei = Brain and nerve 1999;51(6):481-6.
1999: Carlos A Saura; Taisuke Tomita; F Davenport; CL Harris; Takeshi Iwatsubo; Gopal Thinakaran
Evidence that intramolecular associations between presenilin domains are obligatory for endoproteolytic processing.
The Journal of biological chemistry 1999;274(20):13818-23.
1999: Ohoshi Murayama; Taisuke Tomita; N Nihonmatsu; Miyuki Murayama; X Sun; T Honda; Takeshi Iwatsubo; Akihiko Takashima
Enhancement of amyloid beta 42 secretion by 28 different presenilin 1 mutations of familial Alzheimer's disease.
Neuroscience letters 1999;265(1):61-3.
1999: James E Galvin; Virginia M-Y Lee; M Luise Schmidt; Pang-hsien Tu; Takeshi Iwatsubo; John Q Trojanowski
Pathobiology of the Lewy body.
Advances in neurology 1999;80():313-24.
1999: Takeshi Iwatsubo; H Suzuki; Y Sugiyama
Determination of the rate-limiting step in the hepatic elimination of YM796 by isolated rat hepatocytes.
Pharmaceutical research 1999;16(1):110-6.
1998: Eizo Iseki; Wami Marui; Kenji Kosaka; Haruhiko Akiyama; K Ueda; Takeshi Iwatsubo
Degenerative terminals of the perforant pathway are human alpha-synuclein-immunoreactive in the hippocampus of patients with diffuse Lewy body disease.
Neuroscience letters 1998;258(2):81-4.
1998: A Hosomi; K Goto; Hisatake Kondo; Takeshi Iwatsubo; Takanori Yokota; M Ogawa; M Arita; Junken Aoki; Hiroyuki Arai; Kenji Inoue
Localization of alpha-tocopherol transfer protein in rat brain.
Neuroscience letters 1998;256(3):159-62.
1998: S Naruse; Gopal Thinakaran; JJ Luo; John W Kusiak; Taisuke Tomita; Takeshi Iwatsubo; X Qian; David D Ginty; Donald L Price; David R Borchelt; Philip C Wong; Sangram S Sisodia
Effects of PS1 deficiency on membrane protein trafficking in neurons.
Neuron 1998;21(5):1213-21.
1998: R Hosoda; Takaomi C Saido; L Otvos; T Arai; D M A Mann; Virginia M-Y Lee; John Q Trojanowski; Takeshi Iwatsubo
Quantification of modified amyloid beta peptides in Alzheimer disease and Down syndrome brains.
Journal of neuropathology and experimental neurology 1998;57(11):1089-95.
1998: Carol F Lippa; H Fujiwara; D M A Mann; Benoit I Giasson; M Baba; ML Schmidt; Linda E Nee; B O'Connell; Daniel A Pollen; Peter St George-Hyslop; Bernardino Ghetti; David Nochlin; Thomas D Bird; Nigel J Cairns; Virginia M-Y Lee; Takeshi Iwatsubo; John Q Trojanowski
Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes.
The American journal of pathology 1998;153(5):1365-70.
1998: Kenichi Sakai; Hiroshi Homma; JA Lee; T Fukushima; T Santa; K Tashiro; Takeshi Iwatsubo; Kohzoh Imai
Emergence of D-aspartic acid in the differentiating neurons of the rat central nervous system.
Brain research 1998;808(1):65-71.
1998: John Q Trojanowski; Michel Goedert; Takeshi Iwatsubo; Virginia M-Y Lee
Fatal attractions: abnormal protein aggregation and neuron death in Parkinson's disease and Lewy body dementia.
Cell death and differentiation 1998;5(10):832-7.
1998: Takeshi Iwatsubo; Taisuke Tomita
[Genetic factors in the pathogenesis of Alzheimer's disease: roles of beta-amyloid and presenilins].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1998;43(13):1963-72.
1998: Z Long; H Homma; J A Lee; T Fukushima; T Santa; Takeshi Iwatsubo; R Yamada; Kohzoh Imai
Biosynthesis of D-aspartate in mammalian cells.
FEBS letters 1998;434(3):231-5.
1998: Kousei Ito; Takeshi Iwatsubo; S i Kanamitsu; K Ueda; Hiroshi Suzuki; Yuichi Sugiyama
Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver.
Pharmacological reviews 1998;50(3):387-412.
1998: Pang-hsien Tu; James E Galvin; M Baba; Benoit I Giasson; Taisuke Tomita; Susan Leight; S Nakajo; Takeshi Iwatsubo; John Q Trojanowski; Virginia M-Y Lee
Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein.
Annals of neurology 1998;44(3):415-22.
1998: Taisuke Tomita; S Tokuhiro; Tadafumi Hashimoto; K Aiba; Takaomi C Saido; Kei Maruyama; Takeshi Iwatsubo
Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.
The Journal of biological chemistry 1998;273(33):21153-60.
1998: Yorinobu Takigawa; Hiroshi Homma; JA Lee; Takeshi Fukushima; Tomofumi Santa; Takeshi Iwatsubo; Kohzoh Imai
D-aspartate uptake into cultured rat pinealocytes and the concomitant effect on L-aspartate levels and melatonin secretion.
Biochemical and biophysical research communications 1998;248(3):641-7.
1998: Mitsuyasu Kanai; Etsuro Matsubara; K Isoe; Katsuya Urakami; K Nakashima; Heii Arai; Hidetada Sasaki; Koji Abe; Takeshi Iwatsubo; T Kosaka; Mitsunori Watanabe; Yasushi Tomidokoro; M Shizuka; Kazuyuki Mizushima; T Nakamura; Yukifusa Igeta; Yoshio Ikeda; Masakuni Amari; Takeshi Kawarabayashi; Koichi Ishiguro; Yasuo Harigaya; K Wakabayashi; Koichi Okamoto; Shunsaku Hirai; Mikio Shoji
Longitudinal study of cerebrospinal fluid levels of tau, A beta1-40, and A beta1-42(43) in Alzheimer's disease: a study in Japan.
Annals of neurology 1998;44(1):17-26.
1998: Takeshi Iwatsubo; A Hisaka; H Suzuki; Y Sugiyama
Prediction of in vivo nonlinear first-pass hepatic metabolism of YM796 from in vitro metabolic data.
The Journal of pharmacology and experimental therapeutics 1998;286(1):122-7.
1998: Fumitaka Oyama; N Sawamura; K Kobayashi; Maho Morishima-Kawashima; T Kuramochi; Mie Ito; Taisuke Tomita; Kei Maruyama; Takaomi C Saido; Takeshi Iwatsubo; Anja Capell; Jochen Walter; J Grünberg; Yoshito Ueyama; Christian Haass; Yasuo Ihara
Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain.
Journal of neurochemistry 1998;71(1):313-22.
1998: D M A Mann; S M Brown; F Owen; M Baba; Takeshi Iwatsubo
Amyloid beta protein (A beta) deposition in dementia with Lewy bodies: predominance of A beta 42(43) and paucity of A beta 40 compared with sporadic Alzheimer's disease.
Neuropathology and applied neurobiology 1998;24(3):187-94.
1998: K Shinozaki; Kei Maruyama; H Kume; Taisuke Tomita; Takaomi C Saido; Takeshi Iwatsubo; Kunihiko Obata
The presenilin 2 loop domain interacts with the mu-calpain C-terminal region.
International journal of molecular medicine 1998;1(5):797-9.
1998: M Baba; S Nakajo; Pang-hsien Tu; Taisuke Tomita; K Nakaya; Virginia M-Y Lee; John Q Trojanowski; Takeshi Iwatsubo
Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.
The American journal of pathology 1998;152(4):879-84.
1998: Taisuke Tomita; T Y Chang; Tsunenori Kodama; Takeshi Iwatsubo
BetaAPP gamma-secretase and SREBP site 2 protease are two different enzymes.
Neuroreport 1998;9(5):911-3.
1998: S Tokuhiro; Taisuke Tomita; H Iwata; T Kosaka; Takaomi C Saido; Kei Maruyama; Takeshi Iwatsubo
The presenilin 1 mutation (M146V) linked to familial Alzheimer's disease attenuates the neuronal differentiation of NTera 2 cells.
Biochemical and biophysical research communications 1998;244(3):751-5.
1998: Takeshi Iwatsubo
Amyloid beta protein in plasma as a diagnostic marker for Alzheimer's disease.
Neurobiology of aging 1998;19(2):161-3.
1998: K Sakai; Hiroshi Homma; JA Lee; T Fukushima; T Santa; K Tashiro; Takeshi Iwatsubo; Kohzoh Imai
Localization of D-aspartic acid in elongate spermatids in rat testis.
Archives of biochemistry and biophysics 1998;351(1):96-105.
1998: M Luise Schmidt; Virginia M-Y Lee; Takaomi C Saido; Daniel P Perl; Teresa Schuck; Takeshi Iwatsubo; John Q Trojanowski
Amyloid plaques in Guam amyotrophic lateral sclerosis/parkinsonism-dementia complex contain species of A beta similar to those found in the amyloid plaques of Alzheimer's disease and pathological aging.
Acta neuropathologica 1998;95(2):117-22.
1998: Kousei Ito; Takeshi Iwatsubo; S i Kanamitsu; Y Nakajima; Yuichi Sugiyama
Quantitative prediction of in vivo drug clearance and drug interactions from in vitro data on metabolism, together with binding and transport.
Annual review of pharmacology and toxicology 1998;38():461-99.
1998: Takeshi Iwatsubo
Abeta42, presenilins, and Alzheimer's disease.
Neurobiology of aging 1998;19(1 Suppl):S11-3.
1997: Takeshi Iwatsubo; H Suzuki; Y Sugiyama
Prediction of species differences (rats, dogs, humans) in the in vivo metabolic clearance of YM796 by the liver from in vitro data.
The Journal of pharmacology and experimental therapeutics 1997;283(2):462-9.
1997: James E Galvin; Virginia M-Y Lee; M Baba; D M A Mann; dennis dickson; H Yamaguchi; M Luise Schmidt; Takeshi Iwatsubo; John Q Trojanowski
Monoclonal antibodies to purified cortical Lewy bodies recognize the mid-size neurofilament subunit.
Annals of neurology 1997;42(4):595-603.
1997: Yasuhisa Sakurai; K Matsumura; Takeshi Iwatsubo; Toshimitsu Momose
Frontal pure agraphia for kanji or kana: dissociation between morphology and phonology.
Neurology 1997;49(4):946-52.
1997: David G Cook; Mark S Forman; J C Sung; Susan Leight; D L Kolson; Takeshi Iwatsubo; Virginia M-Y Lee; Robert W Doms
Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells.
Nature medicine 1997;3(9):1021-3.
1997: K Tashiro; M Hasegawa; Yasuo Ihara; Takeshi Iwatsubo
Somatodendritic localization of phosphorylated tau in neonatal and adult rat cerebral cortex.
Neuroreport 1997;8(12):2797-801.
1997: Takeshi Iwatsubo; H Suzuki; N Shimada; K Chiba; T Ishizaki; Carol E Green; Charles A Tyson; T Yokoi; T Kamataki; Y Sugiyama
Prediction of in vivo hepatic metabolic clearance of YM796 from in vitro data by use of human liver microsomes and recombinant P-450 isozymes.
The Journal of pharmacology and experimental therapeutics 1997;282(2):909-19.
1997: Kenichi Sakai; Hiroshi Homma; JA Lee; Takeshi Fukushima; Tomofumi Santa; Kei Tashiro; Takeshi Iwatsubo; Kohzoh Imai
D-aspartic acid localization during postnatal development of rat adrenal gland.
Biochemical and biophysical research communications 1997;235(2):433-6.
1997: J Takamatsu; T Kimura; A Kondo; Takeshi Iwatsubo
Subpial amyloid plaques in the cerebellum in a case of Alzheimer's disease.
Dementia and geriatric cognitive disorders 1997;8(3):157-62.
1997: Taisuke Tomita; Kei Maruyama; Takaomi C Saido; H Kume; K Shinozaki; S Tokuhiro; Anja Capell; Jochen Walter; J Grünberg; Christian Haass; Takeshi Iwatsubo; Kunihiko Obata
The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(5):2025-30.
1997: T Kosaka; M Imagawa; K Seki; Hiroyuki Arai; Hidetada Sasaki; S Tsuji; A Asami-Odaka; T Fukushima; K Imai; Takeshi Iwatsubo
The beta APP717 Alzheimer mutation increases the percentage of plasma amyloid-beta protein ending at A beta42(43).
Neurology 1997;48(3):741-5.
1997: JA Lee; Hiroshi Homma; Kenichi Sakai; Takeshi Fukushima; Tomofumi Santa; Kei Tashiro; Takeshi Iwatsubo; M Yoshikawa; Kohzoh Imai
Immunohistochemical localization of D-aspartate in the rat pineal gland.
Biochemical and biophysical research communications 1997;231(2):505-8.
1997: D M A Mann; Stuart Pickering-Brown; N N Bayatti; A E Wright; F Owen; Takeshi Iwatsubo; Takaomi C Saido
An intronic polymorphism in the presenilin-1 gene does not influence the amount or molecular form of the amyloid beta protein deposited in Alzheimer's disease.
Neuroscience letters 1997;222(1):57-60.
1997: D M A Mann; Takeshi Iwatsubo; Stuart Pickering-Brown; F Owen; Takaomi C Saido; Robert H Perry
Preferential deposition of amyloid beta protein (Abeta) in the form Abeta40 in Alzheimer's disease is associated with a gene dosage effect of the apolipoprotein E E4 allele.
Neuroscience letters 1997;221(2-3):81-4.
1997: Ikuo Nishimoto; T Okamoto; U Giambarella; Takeshi Iwatsubo
Apoptosis in neurodegenerative diseases.
Advances in pharmacology (San Diego, Calif.) 1997;41():337-68.
1997: Takeshi Iwatsubo; N Hirota; T Ooie; H Suzuki; N Shimada; K Chiba; T Ishizaki; Carol E Green; Charles A Tyson; Y Sugiyama
Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data.
Pharmacology & therapeutics 1997;73(2):147-71.
1997: D M A Mann; Takeshi Iwatsubo; David Nochlin; Shuzo M Sumi; E Levy-Lahad; Thomas D Bird
Amyloid (Abeta) deposition in chromosome 1-linked Alzheimer's disease: the Volga German families.
Annals of neurology 1997;41(1):52-7.
1996: Yuichi Sugiyama; Takeshi Iwatsubo; K Ueda; K Ito
Strategic proposals for avoiding toxic interactions with drugs for clinical use during development and after marketing of a new drug: pharmacokinetic consideration.
The Journal of toxicological sciences 1996;21(5):309-16.
1996: Takeshi Iwatsubo; Takaomi C Saido; D M A Mann; Virginia M-Y Lee; John Q Trojanowski
Full-length amyloid-beta (1-42(43)) and amino-terminally modified and truncated amyloid-beta 42(43) deposit in diffuse plaques.
The American journal of pathology 1996;149(6):1823-30.
1996: Kei Maruyama; Taisuke Tomita; K Shinozaki; H Kume; H Asada; Takaomi C Saido; S Ishiura; Takeshi Iwatsubo; Kunihiko Obata
Familial Alzheimer's disease-linked mutations at Val717 of amyloid precursor protein are specific for the increased secretion of A beta 42(43).
Biochemical and biophysical research communications 1996;227(3):730-5.
1996: Takaomi C Saido; W Yamao-Harigaya; Takeshi Iwatsubo; S Kawashima
Amino- and carboxyl-terminal heterogeneity of beta-amyloid peptides deposited in human brain.
Neuroscience letters 1996;215(3):173-6.
1996: Kazutomi Kanemaru; Takeshi Iwatsubo; Yasuo Ihara
Comparable amyloid beta-protein (A beta) 42(43) and A beta 40 deposition in the aged monkey brain.
Neuroscience letters 1996;214(2-3):196-8.
1996: D M A Mann; Takeshi Iwatsubo; Nigel J Cairns; P L Lantos; David Nochlin; Shuzo M Sumi; Thomas D Bird; Parvoneh Poorkaj-Navas; John Hardy; Michael Hutton; Guy Prihar; Richard Crook; Martin N Rossor; Matti Haltia
Amyloid beta protein (Abeta) deposition in chromosome 14-linked Alzheimer's disease: predominance of Abeta42(43).
Annals of neurology 1996;40(2):149-56.
1996: Takeshi Iwatsubo; H Yamaguchi; Masahiro Fujimuro; Hideyoshi Yokosawa; Yasuo Ihara; John Q Trojanowski; Virginia M-Y Lee
Lewy bodies: purification from diffuse Lewy body disease brains.
Annals of the New York Academy of Sciences 1996;786():195-205.
1996: D M A Mann; Takeshi Iwatsubo
Diffuse plaques in the cerebellum and corpus striatum in Down's syndrome contain amyloid beta protein (A beta) only in the form of A beta 42(43).
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 1996;5(2):115-20.
1996: T Yamatsuji; T Matsui; T Okamoto; Katsumi Komatsuzaki; S Takeda; H Fukumoto; Takeshi Iwatsubo; N Suzuki; A Asami-Odaka; S Ireland; T Bernard Kinane; U Giambarella; Ikuo Nishimoto
G protein-mediated neuronal DNA fragmentation induced by familial Alzheimer's disease-associated mutants of APP.
Science (New York, N.Y.) 1996;272(5266):1349-52.
1996: Takeshi Iwatsubo; N Hirota; T Ooie; H Suzuki; Yuichi Sugiyama
Prediction of in vivo drug disposition from in vitro data based on physiological pharmacokinetics.
Biopharmaceutics & drug disposition 1996;17(4):273-310.
1996: Takeshi Iwatsubo; H Yamaguchi; Masahiro Fujimuro; Hideyoshi Yokosawa; Yasuo Ihara; John Q Trojanowski; Virginia M-Y Lee
Purification and characterization of Lewy bodies from the brains of patients with diffuse Lewy body disease.
The American journal of pathology 1996;148(5):1517-29.
1996: D M A Mann; Takeshi Iwatsubo; Yasuo Ihara; Nigel J Cairns; P L Lantos; Nenad Bogdanovic; Lars Lannfelt; Bengt Winblad; M L Maat-Schieman; Martin N Rossor
Predominant deposition of amyloid-beta 42(43) in plaques in cases of Alzheimer's disease and hereditary cerebral hemorrhage associated with mutations in the amyloid precursor protein gene.
The American journal of pathology 1996;148(4):1257-66.
1996: Imaharu Nakano; Takeshi Iwatsubo; N Otsuka; M Kamei; K Matsumura; T Mannen
Some unusual responses of astrocytes to ghost tangles in a long duration case of juvenile Alzheimer's disease: an electron microscopic study.
Journal of the neurological sciences 1996;136(1-2):41-6.
1996: H Fukumoto; A Asami-Odaka; N Suzuki; Takeshi Iwatsubo
Association of A beta 40-positive senile plaques with microglial cells in the brains of patients with Alzheimer's disease and in non-demented aged individuals.
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 1996;5(1):13-7.
1996: H Kume; Kei Maruyama; Taisuke Tomita; Takeshi Iwatsubo; Takaomi C Saido; Kunihiko Obata
Molecular cloning of a novel basic helix-loop-helix protein from the rat brain.
Biochemical and biophysical research communications 1996;219(2):526-30.
1996: D M A Mann; Takeshi Iwatsubo; Julie S Snowden
Atypical amyloid (A beta) deposition in the cerebellum in Alzheimer's disease: an immunohistochemical study using end-specific A beta monoclonal antibodies.
Acta neuropathologica 1996;91(6):647-53.
1996: H Fukumoto; A Asami-Odaka; N Suzuki; H Shimada; Yasuo Ihara; Takeshi Iwatsubo
Amyloid beta protein deposition in normal aging has the same characteristics as that in Alzheimer's disease. Predominance of A beta 42(43) and association of A beta 40 with cored plaques.
The American journal of pathology 1996;148(1):259-65.
1995: H Suzuki; Takeshi Iwatsubo; Yuichi Sugiyama
Applications and prospects for physiologically based pharmacokinetic (PB-PK) models involving pharmaceutical agents.
Toxicology letters 1995;82-83():349-55.
1995: D M A Mann; Stuart Pickering-Brown; M A Siddons; Takeshi Iwatsubo; Yasuo Ihara; A Asami-Odaka; N Suzuki
The extent of amyloid deposition in brain in patients with Down's syndrome does not depend upon the apolipoprotein E genotype.
Neuroscience letters 1995;196(1-2):105-8.
1995: Takeshi Iwatsubo; D M A Mann; A Odaka; N Suzuki; Yasuo Ihara
Amyloid beta protein (A beta) deposition: A beta 42(43) precedes A beta 40 in Down syndrome.
Annals of neurology 1995;37(3):294-9.
1995: Takaomi C Saido; Takeshi Iwatsubo; D M A Mann; H Shimada; Yasuo Ihara; S Kawashima
Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques.
Neuron 1995;14(2):457-66.
1995: D M A Mann; Takeshi Iwatsubo; H Fukumoto; Yasuo Ihara; A Odaka; N Suzuki
Microglial cells and amyloid beta protein (A beta) deposition; association with A beta 40-containing plaques.
Acta neuropathologica 1995;90(5):472-7.
1994: Heii Arai; S Higuchi; T Muramatsu; Takeshi Iwatsubo; H Sasaki; John Q Trojanowski
Apolipoprotein E gene in diffuse Lewy body disease with or without co-existing Alzheimer's disease.
Lancet 1994;344(8932):1307.
1994: N Suzuki; Takeshi Iwatsubo; A Odaka; Y Ishibashi; Chieko Kitada; Yasuo Ihara
High tissue content of soluble beta 1-40 is linked to cerebral amyloid angiopathy.
The American journal of pathology 1994;145(2):452-60.
1994: Takeshi Iwatsubo; A Odaka; N Suzuki; H Mizusawa; Nobuyuki Nukina; Yasuo Ihara
Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).
Neuron 1994;13(1):45-53.
1994: Takeshi Iwatsubo; M Hasegawa; Yasuo Ihara
Neuronal and glial tau-positive inclusions in diverse neurologic diseases share common phosphorylation characteristics.
Acta neuropathologica 1994;88(2):129-36.
1993: R Endoh; M Ogawara; Takeshi Iwatsubo; I Nakano; Hiroshi Mori
Lack of the carboxyl terminal sequence of tau in ghost tangles of Alzheimer's disease.
Brain research 1993;601(1-2):164-72.
1993: Takeshi Iwatsubo; A Kanemitsu
[The pyramidal tract in man].
Nō to shinkei = Brain and nerve 1993;45(1):21-37.
1993: Imaharu Nakano; Takeshi Iwatsubo; Y Hashizume; T Mizutani
Bunina bodies in neurons of the medullary reticular formation in amyotrophic lateral sclerosis.
Acta neuropathologica 1993;85(5):471-4.
1992: Takeshi Iwatsubo
[Japanese clinical statistical data of progressive supranuclear palsy].
Nihon rinsho. Japanese journal of clinical medicine 1992;50 Suppl():134-8.
1992: Masahiro Sonoo; K Genba; Takeshi Iwatsubo; T Mannen
P15 in tibial nerve SEPs as an example of the junctional potential.
Electroencephalography and clinical neurophysiology 1992;84(6):486-91.
1992: H Bito; M Nakamura; Zen-ichiro Honda; Takashi Izumi; Takeshi Iwatsubo; Yousuke Seyama; A Ogura; Y Kudo; T Shimizu
Platelet-activating factor (PAF) receptor in rat brain: PAF mobilizes intracellular Ca2+ in hippocampal neurons.
Neuron 1992;9(2):285-94.
1992: T Wakabayashi; Shinichi Oka; K Shimada; I Nakano; Takeshi Iwatsubo; S Mori
Disseminated Pneumocystis carinii infection in a hemophiliac patient with acquired immunodeficiency syndrome.
Acta pathologica japonica 1992;42(4):262-6.
1992: Takeshi Iwatsubo; M Hasegawa; Y Esaki; Yasuo Ihara
Lack of ubiquitin immunoreactivities at both ends of neuropil threads. Possible bidirectional growth of neuropil threads.
The American journal of pathology 1992;140(2):277-82.
1992: I Nakano; Takeshi Iwatsubo; N Otsuka; M Kamei; K Matsumura; T Mannen
Paired helical filaments in astrocytes: electron microscopy and immunohistochemistry in a case of atypical Alzheimer's disease.
Acta neuropathologica 1992;83(3):228-32.
1992: N Takahashi; Takeshi Iwatsubo; I Nakano; Rikuo Machinami
Focal appearance of cerebellar torpedoes associated with discrete lesions in the cerebellar white matter.
Acta neuropathologica 1992;84(2):153-6.
1991: Takeshi Iwatsubo; I Nakano; Tsuyoshi Tange; Yasuo Terauchi; Masahiro Sonoo
[Mono-radiculopathy multiplex--multiple infarction of the cauda equina caused by intravascular lymphomatosis].
Rinshō shinkeigaku = Clinical neurology 1991;31(11):1229-34.
1991: Takeshi Iwatsubo; T Kimura; K Inoue
[Perifascicular necrosis and regeneration in a case of adult polymyositis].
Rinshō shinkeigaku = Clinical neurology 1991;31(4):439-44.
1991: Takeshi Iwatsubo; I Nakano; K Fukunaga; E Miyamoto
Ca2+/calmodulin-dependent protein kinase II immunoreactivity in Lewy bodies.
Acta neuropathologica 1991;82(3):159-63.
1990: Takeshi Iwatsubo; Y Ishige; Nobuyuki Nukina; T Mannen
[Chronic human colchicine myopathy].
Rinshō shinkeigaku = Clinical neurology 1990;30(9):1001-4.
1990: Takeshi Iwatsubo; S Kuzuhara; A Kanemitsu; H Shimada; Y Toyokura
Corticofugal projections to the motor nuclei of the brainstem and spinal cord in humans.
Neurology 1990;40(2):309-12.
1989: Takeshi Iwatsubo; C Sakanaka; T Obi; K Takeda; M Sakuta
[Chronic inflammatory demyelinating polyradiculoneuropathy of acute onset: relapse after temporary improvement by plasma exchange and longstanding remission by corticosteroid therapy].
Rinshō shinkeigaku = Clinical neurology 1989;29(7):930-2.
1989: Takeshi Iwatsubo; M Yamazaki; Yuichi Sugiyama; H Suzuki; S Yanai; D C Kim; H Satoh; Y Miyamoto; Tatsuji Iga; Manabu Hanano
Epidermal growth factor as a regulatory hormone maintaining a low pH microclimate in the rat small intestine.
Journal of pharmaceutical sciences 1989;78(6):457-9.
1988: Takeshi Iwatsubo; K Arahata; Y Motoyoshi; S Murayama; T Mannen
[Co-existence of clinical and immunohistochemical features of polymyositis and myasthenia gravis].
Rinshō shinkeigaku = Clinical neurology 1988;28(8):913-8.
1988: hitoshi okazawa; I Moriuchi; Takeshi Iwatsubo; K Takeda; M Sakuta
[Bilateral horizontal gaze palsy due to hemi-tegmental lesion in a case of pontine infarction].
Rinshō shinkeigaku = Clinical neurology 1988;28(7):803-7.
1988: Takeshi Iwatsubo; Yuichi Sugiyama; Y Miyamoto; F H Leibach; H Suzuki; Tatsuji Iga; Manabu Hanano
Effects of phenothiazine derivatives on the microclimate-pH in the rat jejunum.
Journal of pharmaceutical sciences 1988;77(7):586-90.
1988: Takeshi Iwatsubo; H Yamada; H Kawakami; K Hirokawa; M Sonobe
[On the mechanism of symptomatic development in syringomyelobulbia].
Rinshō shinkeigaku = Clinical neurology 1988;28(2):129-32.
1987: Takeshi Iwatsubo; M Iwata; K Inoue; T Mannen
[Magnetic resonance imaging in a case of paramedian mesencephalic infarction].
Revue neurologique 1987;143(8-9):605-7.