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David Ayares

Research Profile

Chemicals & Drugs

Living Beings

Procedures

Physiology

Anatomy

Leukocytes, Mononuclear

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Publications

TOP 3
Dirk J van der Windt; Martin Wijkstrom; David Ayares; Rita Bottino; Anna Casu; Burcin Ekser; Mohamed Ezzelarab; Hidetaka Hara; Goutham Kumar; Fadi G Lakkis; Noriko Murase; Carol Phelps; Massimo Trucco; David K C Cooper
Clinical islet xenotransplantation: how close are we?
Burcin Ekser; Mohamed Ezzelarab; Bruno Gridelli; Hayato Iwase; Massimiliano Veroux; Robert Wagner; Anneke Walters; David Ayares; Suyapa Ball; John Bianchi; David K C Cooper
Comparison of hematologic, biochemical, and coagulation parameters in α1,3-galactosyltransferase gene-knockout pigs, wild-type pigs, and four primate species.
Burcin Ekser; Bruno Gridelli; Andrew J Lutz; Leela L Paris; Michael A Rees; Simon C Robson; A Joseph Tector; Massimiliano Veroux; Joshua P Waldman; David Ayares; Christopher Burlak; David Kc Cooper
Immunobiology of liver xenotransplantation.

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All Publications

2012: Dirk J van der Windt; Martin Wijkstrom; David Ayares; Rita Bottino; Anna Casu; Burcin Ekser; Mohamed Ezzelarab; Hidetaka Hara; Goutham Kumar; Fadi G Lakkis; Noriko Murase; Carol Phelps; Massimo Trucco; David K C Cooper
Clinical islet xenotransplantation: how close are we?
Diabetes 2012;61(12):3046-55.
2012: Burcin Ekser; Mohamed Ezzelarab; Bruno Gridelli; Hayato Iwase; Massimiliano Veroux; Robert Wagner; Anneke Walters; David Ayares; Suyapa Ball; John Bianchi; David K C Cooper
Comparison of hematologic, biochemical, and coagulation parameters in α1,3-galactosyltransferase gene-knockout pigs, wild-type pigs, and four primate species.
Xenotransplantation 2012;19(6):342-54.
2012: Burcin Ekser; Bruno Gridelli; Andrew J Lutz; Leela L Paris; Michael A Rees; Simon C Robson; A Joseph Tector; Massimiliano Veroux; Joshua P Waldman; David Ayares; Christopher Burlak; David Kc Cooper
Immunobiology of liver xenotransplantation.
Expert review of clinical immunology 2012;8(7):621-34.
2012: Corin Ezzelarab; David Ayares; David K C Cooper; Mohamed B Ezzelarab
Human T-cell proliferation in response to thrombin-activated GTKO pig endothelial cells.
Xenotransplantation 2012;19(5):311-6.
2012: Jason Fang; Hidetaka Hara; Cassandra Long; Anneke Walters; Peter Yeh; David Ayares; David K C Cooper; John Bianchi
Anti-gal antibodies in α1,3-galactosyltransferase gene-knockout pigs.
Xenotransplantation 2012;19(5):305-10.
2012: Burcin Ekser; Keiichi Enjyoji; Mohamed Ezzelarab; David Ayares; Vladimir Y Bogdanov; David K C Cooper; Anthony Dorling; Gabriel J Echeverri; Hidetaka Hara; Chih C Lin; Cassandra Long; Simon C Robson; Donna B Stolz; Bruno Gridelli
Potential factors influencing the development of thrombocytopenia and consumptive coagulopathy after genetically modified pig liver xenotransplantation.
Transplant international : official journal of the European Society for Organ Transplantation 2012;25(8):882-96.
2012: Mohamed B Ezzelarab; Bertha Garcia; Hidetaka Hara; Cassandra Long; Noriko Murase; David Ayares; Pietro Bajona; Gabriel Echeverri; Burcin Ekser; Corin Ezzelarab; David K C Cooper
Costimulation blockade in pig artery patch xenotransplantation - a simple model to monitor the adaptive immune response in nonhuman primates.
Xenotransplantation 2012;19(4):221-32.
2012: David K C Cooper; Burcin Ekser; Mohamed Ezzelarab; Hidetaka Hara; Leela Paris; Carol Phelps; David Ayares; Agnes M Azimzadeh; Christopher Burlak; Simon C Robson; A Joseph Tector; Richard N Pierson III
Clinical lung xenotransplantation--what donor genetic modifications may be necessary?
Xenotransplantation 2012;19(3):144-58.
2012: Goutham Kumar; Cassandra Long; Humza Shaikh; David Ayares; David K C Cooper; Hidetaka Hara; Mohamed Ezzelarab
Adipose-derived mesenchymal stromal cells from genetically modified pigs: immunogenicity and immune modulatory properties.
Cytotherapy 2012;14(4):494-504.
2012: M M Mohiuddin; Richard N Pierson III; C Seavey; A K Singh; M L Thomas; David Ayares; Agnes M Azimzadeh; P C Corcoran; M A Eckhaus; R F Hoyt; Keith Horvath
B-cell depletion extends the survival of GTKO.hCD46Tg pig heart xenografts in baboons for up to 8 months.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2012;12(3):763-71.
2012: Dirk J van der Windt; Tatyana V Votyakova; David Ayares; David K C Cooper; Gabriel J Echeverri; Burcin Ekser; Jing He; Fadi G Lakkis; Marco Marigliano; Massimo Trucco; Rita Bottino
Early islet damage after direct exposure of pig islets to blood: has humoral immunity been underestimated?
Cell transplantation 2012;21(8):1791-802.
2012: Tyler Wilhite; Hidetaka Hara; Cassandra Long; David Ayares; David K C Cooper; Corin Ezzelarab; Mohamed Ezzelarab
The effect of Gal expression on pig cells on the human T-cell xenoresponse.
Xenotransplantation 2012;19(1):56-63.
2012: Elisabeth Kemter; Barbara Kessler; Mayuko Kurome; Thorsten Lieke; Hiroshi Nagashima; Reinhard Schwinzer; Artur Summerfield; David Ayares; Wiebke Baars; Annegret Wuensch; Eckhard Wolf
Human TNF-related apoptosis-inducing ligand-expressing dendritic cells from transgenic pigs attenuate human xenogeneic T cell responses.
Xenotransplantation 2012;19(1):40-51.
2012: Burcin Ekser; Mohamed Ezzelarab; David Ayares; David K C Cooper; Gabriel J Echeverri; Hidetaka Hara; Jing He; Edwin Klein; Chih Che Lin; Cassandra Long; Donna B Stolz; Massimiliano Veroux; Bruno Gridelli
Genetically-engineered pig-to-baboon liver xenotransplantation: histopathology of xenografts and native organs.
PloS one 2012;7(1):e29720.
2011: Tadatsura Koshika; Seung Eun Lee; Carol Phelps; David Ayares; David K C Cooper; Jason Fang; Minoru Fujita; Hidetaka Hara
Relative efficiency of porcine and human cytotoxic T-lymphocyte antigen 4 immunoglobulin in inhibiting human CD4+ T-cell responses co-stimulated by porcine and human B7 molecules.
Immunology 2011;134(4):386-97.
2011: Mohamed Ezzelarab; Hidetaka Hara; Goutham Kumar; Tyler Wilhite; David Ayares; Corin Ezzelarab; David K C Cooper
Genetically-modified pig mesenchymal stromal cells: xenoantigenicity and effect on human T-cell xenoresponses.
Xenotransplantation 2011;18(3):183-95.
2011: David K C Cooper; David Ayares
The immense potential of xenotransplantation in surgery.
International journal of surgery (London, England) 2011;9(2):122-9.
2010: Burcin Ekser; Gabriel J Echeverri; Andrea Cortese Hassett; Mark H Yazer; Cassandra Long; Michael Meyer; Mohamed Ezzelarab; Chih Che Lin; Hidetaka Hara; Dirk J van der Windt; Eefje M Dons; Carol Phelps; David Ayares; David K C Cooper; Bruno Gridelli
Hepatic function after genetically engineered pig liver transplantation in baboons.
Transplantation 2010;90(5):483-93.
2010: Hidetaka Hara; Nathalie Campanile; Hao-Chih Tai; Cassandra Long; Burcin Ekser; Peter Yeh; Dan Welchons; Mohamed Ezzelarab; David Ayares; David K C Cooper
An in vitro model of pig liver xenotransplantation--pig complement is associated with reduced lysis of wild-type and genetically modified pig cells.
Xenotransplantation 2010;17(5):370-8.
2010: Chih-Che Lin; Mohamed Ezzelarab; Ron Shapiro; Burcin Ekser; C Long; Hidetaka Hara; G Echeverri; C Torres; H Watanabe; David Ayares; A Dorling; D K C Cooper
Recipient tissue factor expression is associated with consumptive coagulopathy in pig-to-primate kidney xenotransplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2010;10(7):1556-68.
2010: Peter Yeh; Mohamed Ezzelarab; Nicolai Bovin; Hidetaka Hara; Cassandra Long; Koji Tomiyama; Frank Sun; David Ayares; Michel Awwad; David K C Cooper
Investigation of potential carbohydrate antigen targets for human and baboon antibodies.
Xenotransplantation 2010;17(3):197-206.
2010: Anna Casu; Gabriel J Echeverri; Rita Bottino; Dirk J van der Windt; Jing He; Burcin Ekser; Suyapa Ball; David Ayares; David K C Cooper
Insulin secretion and glucose metabolism in alpha 1,3-galactosyltransferase knock-out pigs compared to wild-type pigs.
Xenotransplantation 2010;17(2):131-9.
2010: Burcin Ekser; C Long; G J Echeverri; Hidetaka Hara; Mohamed Ezzelarab; Chih-Che Lin; Michael de Vera; Robert Wagner; Edwin Klein; Roman F Wolf; David Ayares; D K C Cooper; Bruno Gridelli
Impact of thrombocytopenia on survival of baboons with genetically modified pig liver transplants: clinical relevance.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2010;10(2):273-85.
2010: Mette Diswall; Jonas Angström; Hasse Karlsson; Carol J Phelps; David Ayares; Susann Teneberg; Michael E Breimer
Structural characterization of alpha1,3-galactosyltransferase knockout pig heart and kidney glycolipids and their reactivity with human and baboon antibodies.
Xenotransplantation 2010;17(1):48-60.
2010: Mohamed Ezzelarab; David Ayares; David K C Cooper
The potential of genetically-modified pig mesenchymal stromal cells in xenotransplantation.
Xenotransplantation 2010;17(1):3-5.
2009: Dirk J van der Windt; Rita Bottino; Anna Casu; N Campanile; Cynthia Smetanka; Jing He; N Murase; Hidetaka Hara; S Ball; B E Loveland; David Ayares; F G Lakkis; D K C Cooper; Massimo Trucco
Long-term controlled normoglycemia in diabetic non-human primates after transplantation with hCD46 transgenic porcine islets.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2009;9(12):2716-26.
2009: Kerry A Daly; Ann M Stewart-Akers; Hidetaka Hara; Mohamed Ezzelarab; Cassandra Long; Kevin Cordero; Scott A Johnson; David Ayares; David K C Cooper; Stephen F Badylak
Effect of the alphaGal epitope on the response to small intestinal submucosa extracellular matrix in a nonhuman primate model.
Tissue engineering. Part A 2009;15(12):3877-88.
2009: Nicolas J Mueller; Mohamed Ezzelarab; Leo Buhler; Lea Haeberli; David Ayares; David K C Cooper
Monitoring of porcine and baboon cytomegalovirus infection in xenotransplantation.
Xenotransplantation 2009;16(6):535-6.
2009: Cassandra Long; Hidetaka Hara; Zachary Pawlikowski; Naoko Koike; Thomas d'Arville; Peter Yeh; Mohamed Ezzelarab; David Ayares; Mark Yazer; David K C Cooper
Genetically engineered pig red blood cells for clinical transfusion: initial in vitro studies.
Transfusion 2009;49(11):2418-29.
2009: Richard N Pierson III; Anthony Dorling; David Ayares; Michael A Rees; Jörg D Seebach; Jay A Fishman; Bernhard J Hering; David K C Cooper
Current status of xenotransplantation and prospects for clinical application.
Xenotransplantation 2009;16(5):263-80.
2009: Jagdeece Ramsoondar; Todd Vaught; Suyapa Ball; Michael Mendicino; Jeff Monahan; Peter Jobst; Amy Vance; Jane Duncan; Kevin Wells; David Ayares
Production of transgenic pigs that express porcine endogenous retrovirus small interfering RNAs.
Xenotransplantation 2009;16(3):164-80.
2009: Mohamed Ezzelarab; Bertha Garcia; Agnes M Azimzadeh; Hongtao Sun; Chih-Che Lin; Hidetaka Hara; Sean Kelishadi; Tianshu Zhang; Yih-Jyh Lin; Hao-Chih Tai; Robert Wagner; Jnanesh Thacker; Noriko Murase; Kenneth R McCurry; Rolf N Barth; David Ayares; Richard N Pierson III; David K C Cooper
The innate immune response and activation of coagulation in alpha1,3-galactosyltransferase gene-knockout xenograft recipients.
Transplantation 2009;87(6):805-12.
2008: Hidetaka Hara; Cassandra Long; Yih-Jyh Lin; Hao-Chih Tai; Mohamed Ezzelarab; David Ayares; David K C Cooper
In vitro investigation of pig cells for resistance to human antibody-mediated rejection.
Transplant international : official journal of the European Society for Organ Transplantation 2008;21(12):1163-74.
2008: Yih-Jyh Lin; Hidetaka Hara; Hao-Chih Tai; Cassandra Long; Daisuke Tokita; Peter Yeh; David Ayares; Adrian E Morelli; David K C Cooper
Suppressive efficacy and proliferative capacity of human regulatory T cells in allogeneic and xenogeneic responses.
Transplantation 2008;86(10):1452-62.
2008: Mohamed Ezzelarab; Daniel Welchons; Corine Torres; Hidetaka Hara; Cassandra Long; Peter Yeh; David Ayares; David K C Cooper
Atorvastatin down-regulates the primate cellular response to porcine aortic endothelial cells in vitro.
Transplantation 2008;86(5):733-7.
2008: David K C Cooper; Mohamed Ezzelarab; Hidetaka Hara; David Ayares
Recent advances in pig-to-human organ and cell transplantation.
Expert opinion on biological therapy 2008;8(1):1-4.
2007: Pleunie P M Rood; Hao-Chih Tai; Hidetaka Hara; Cassandra Long; Mohamed Ezzelarab; Yih J Lin; Dirk J van der Windt; Jamie Busch; David Ayares; Jan N M Ijzermans; Roman F Wolf; Rizwan Manji; Leonard Bailey; David K C Cooper
Late onset of development of natural anti-nonGal antibodies in infant humans and baboons: implications for xenotransplantation in infants.
Transplant international : official journal of the European Society for Organ Transplantation 2007;20(12):1050-8.
2007: David K C Cooper; Anthony Dorling; Richard N Pierson III; Michael Rees; Jorg Seebach; Mark H Yazer; Hideki Ohdan; Michel Awwad; David Ayares
Alpha1,3-galactosyltransferase gene-knockout pigs for xenotransplantation: where do we go from here?
Transplantation 2007;84(1):1-7.
2007: Hao-Chih Tai; Xiaocheng Zhu; Hidetaka Hara; Yih-Jyh Lin; Mohamed Ezzelarab; Cassandra Long; Suyapa Ball; David Ayares; David K C Cooper
The pig-to-primate immune response: relevance for xenotransplantation.
Xenotransplantation 2007;14(3):227-35.
2007: Bao-Ngoc H Nguyen; Agnes M Azimzadeh; Tianshu Zhang; Guosheng Wu; Henk-Jan Schuurman; Henk-Jan Shuurman; David H Sachs; David Ayares; James S Allan; Richard N Pierson III
Life-supporting function of genetically modified swine lungs in baboons.
The Journal of thoracic and cardiovascular surgery 2007;133(5):1354-63.
2007: Hao-Chih Tai; Mohamed Ezzelarab; Hidetaka Hara; David Ayares; David K C Cooper
Progress in xenotransplantation following the introduction of gene-knockout technology.
Transplant international : official journal of the European Society for Organ Transplantation 2007;20(2):107-17.
2007: Pleunie P M Rood; Rita Bottino; AN Balamurugan; Cynthia Smetanka; David Ayares; Carl-Gustav Groth; Noriko Murase; David K C Cooper; Massimo Trucco
Reduction of early graft loss after intraportal porcine islet transplantation in monkeys.
Transplantation 2007;83(2):202-10.
2007: Le Jiang; Pete Jobst; Liangxue Lai; Melissa Samuel; David Ayares; Randall S Prather; X Cindy Tian
Expression levels of growth-regulating imprinted genes in cloned piglets.
Cloning and stem cells 2007;9(1):97-106.
2006: Mohamed Ezzelarab; Hidetaka Hara; Jamie Busch; Pleunie P M Rood; Xiaocheng Zhu; Zuhaib Ibrahim; Suyapa Ball; David Ayares; Michel Awwad; David K C Cooper
Antibodies directed to pig non-Gal antigens in naïve and sensitized baboons.
Xenotransplantation 2006;13(5):400-7.
2006: Hidetaka Hara; Mohamed Ezzelarab; Pleunie P M Rood; Yih-Jyh Lin; Jamie Busch; Zuhaib Ibrahim; Xiaocheng Zhu; Suyapa Ball; David Ayares; Adriana Zeevi; Michel Awwad; David K C Cooper
Allosensitized humans are at no greater risk of humoral rejection of GT-KO pig organs than other humans.
Xenotransplantation 2006;13(4):357-65.
2006: Pleunie P M Rood; Pleunic P M Rood; Hidetaka Hara; Jamie Busch; Mohamed Ezzelarab; Xiaocheng Zhu; Suyapa Ball; David Ayares; Michel Awwad; David K C Cooper
Incidence and cytotoxicity of antibodies in cynomolgus monkeys directed to nonGal antigens, and their relevance for experimental models.
Transplant international : official journal of the European Society for Organ Transplantation 2006;19(2):158-65.
2005: Pleunie P M Rood; Hidetaka Hara; Mohamed Ezzelarab; Jamie Busch; Xiaocheng Zhu; Zuhaib Ibrahim; Suyapa Ball; David Ayares; Michel Awwad; David K C Cooper
Preformed antibodies to alpha1,3-galactosyltransferase gene-knockout (GT-KO) pig cells in humans, baboons, and monkeys: implications for xenotransplantation.
Transplantation proceedings 2005;37(8):3514-5.
2005: Mohamed Ezzelarab; David Ayares; David K C Cooper
Carbohydrates in xenotransplantation.
Immunology and cell biology 2005;83(4):396-404.
2003: Carol J Phelps; Chihiro Koike; Todd D Vaught; Jeremy Boone; Kevin D Wells; Shu-Hung Chen; Suyapa Ball; Susan M Specht; Irina A Polejaeva; Jeff A Monahan; Peter M Jobst; Sugandha B Sharma; Ashley E Lamborn; Amy S Garst; Marilyn Moore; Anthony J Demetris; William A Rudert; Rita Bottino; Suzanne Bertera; Massimo Trucco; Thomas E Starzl; Yifan Dai; David Ayares
Production of alpha 1,3-galactosyltransferase-deficient pigs.
Science (New York, N.Y.) 2003;299(5605):411-4.
2002: Shu-Hung Chen; Todd D Vaught; Jeff A Monahan; Jeremy Boone; Elizabeth Emslie; Peter M Jobst; Ashley E Lamborn; Angelika Schnieke; Laura Robertson; Alan Colman; Yifan Dai; Irina A Polejaeva; David Ayares
Efficient production of transgenic cloned calves using preimplantation screening.
Biology of reproduction 2002;67(5):1488-92.
2002: Yifan Dai; Todd D Vaught; Jeremy Boone; Shu-Hung Chen; Carol J Phelps; Suyapa Ball; Jeff A Monahan; Peter M Jobst; Kenneth J McCreath; Ashley E Lamborn; Jamie L Cowell-Lucero; Kevin D Wells; Alan Colman; Irina A Polejaeva; David Ayares
Targeted disruption of the alpha1,3-galactosyltransferase gene in cloned pigs.
Nature biotechnology 2002;20(3):251-5.
2001: J T Keiser; Peter M Jobst; A S Garst; J T Boone; C B Geyer; Carol J Phelps; David Ayares; R L Page
Preimplantation screening for transgenesis using an embryonic specific promoter and green fluorescent protein.
Cloning 2001;3(1):23-30.
2000: Irina A Polejaeva; Shu-Hung Chen; Todd D Vaught; R L Page; J Mullins; Suyapa Ball; Yifan Dai; Jeremy Boone; S Walker; David Ayares; Alan Colman; Keith Campbell
Cloned pigs produced by nuclear transfer from adult somatic cells.
Nature 2000;407(6800):86-90.