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Lara Izotova

Research Profile

Concepts & Ideas

Molecular Sequence Data

Chemicals & Drugs

Genes & Molecular Sequences

Amino Acid Sequences

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Physiology

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Cloning, Molecular

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Publications

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Christopher D Krause; Chiann-Chyi Chen; Lara Izotova; Gwangwen Ren; Yacov Ron; Yufang Shi; Zeng-Rong Yuan; Sidney Pestka
Efficient co-expression of bicistronic proteins in mesenchymal stem cells by development and optimization of a multifunctional plasmid.
Kristin Walberg; Samuel Baron; Joyce Poast; Barbara Schwartz; Lara Izotova; Sidney Pestka; Johnny W Peterson
Interferon protects mice against inhalation anthrax.
Victor Adler; Wilbur Bowne; Josef Michl; Kelley A Sookraj; Kamran Ikram; Sidney Pestka; Lara Izotova; Michael Zenilman; Fred Friedman; Yongxia Qu; Matthew R Pincus
Site-specific phosphorylation of raf in cells containing oncogenic ras-p21 is likely mediated by jun-N-terminal kinase.

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All Publications

2011: Christopher D Krause; Chiann-Chyi Chen; Lara Izotova; Gwangwen Ren; Yacov Ron; Yufang Shi; Zeng-Rong Yuan; Sidney Pestka
Efficient co-expression of bicistronic proteins in mesenchymal stem cells by development and optimization of a multifunctional plasmid.
Stem cell research & therapy 2011;2(2):15.
2008: Kristin Walberg; Samuel Baron; Joyce Poast; Barbara Schwartz; Lara Izotova; Sidney Pestka; Johnny W Peterson
Interferon protects mice against inhalation anthrax.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2008;28(10):597-601.
2008: Victor Adler; Wilbur Bowne; Josef Michl; Kelley A Sookraj; Kamran Ikram; Sidney Pestka; Lara Izotova; Michael Zenilman; Fred Friedman; Yongxia Qu; Matthew R Pincus
Site-specific phosphorylation of raf in cells containing oncogenic ras-p21 is likely mediated by jun-N-terminal kinase.
Annals of clinical and laboratory science 2008;38(1):47-56.
2007: Yongxia Qu; Victor Adler; Lara Izotova; Sidney Pestka; Wilbur B Bowne; Josef Michl; Mohamed Boutjdir; Fred Friedman; Matthew R Pincus
The dual-specificity kinases, TOPK and DYRK1A, are critical for oocyte maturation induced by wild-type--but not by oncogenic--ras-p21 protein.
Frontiers in bioscience : a journal and virtual library 2007;12():5089-97.
2006: Yongxia Qu; Victor Adler; Tearina Chu; Ovidu Platica; Josef Michl; Sidney Pestka; Lara Izotova; Mohamed Boutjdir; Matthew R Pincus
Two dual specificity kinases are preferentially induced by wild-type rather than by oncogenic RAS-P21 in Xenopus oocytes.
Frontiers in bioscience : a journal and virtual library 2006;11():2420-7.
2005: Victor Adler; Yongxia Qu; Steven J Smith; Lara Izotova; Sidney Pestka; Hsiang-Fu Kung; Marie Lin; Fred Friedman; Lyndon Chie; Denise Chung; Mohamed Boutjdir; Matthew R Pincus
Functional interactions of Raf and MEK with Jun-N-terminal kinase (JNK) result in a positive feedback loop on the oncogenic Ras signaling pathway.
Biochemistry 2005;44(32):10784-95.
2004: Naomi J Logsdon; Brandi C Jones; Jennifer C Allman; Lara Izotova; Barbara Schwartz; Sidney Pestka; Mark R Walter
The IL-10R2 binding hot spot on IL-22 is located on the N-terminal helix and is dependent on N-linked glycosylation.
Journal of molecular biology 2004;342(2):503-14.
2004: Wei Wu; John E Kerrigan; Prem Yadav; Barbara Schwartz; Lara Izotova; Thomas B Lavoie; Sidney Pestka
Design and construction of a phosphorylatable chimeric monoclonal antibody with a highly stable phosphate.
Oncology research 2004;14(11-12):541-58.
2002: Tracy L Garrison; Finn Hung; Lara Izotova; Barbara Schwartz; Thomas Lavoie; F Victor Lee-Own
ELISA measurement of interferons.
BioTechniques 2002;Suppl():98-100.
2002: William A Clark; Lara Izotova; Doranelly Philipova; Wei Wu; Lei Lin; Sidney Pestka
Site-specific 32P-labeling of cytokines, monoclonal antibodies, and other protein substrates for quantitative assays and therapeutic application.
BioTechniques 2002;Suppl():76-8, 80-7.
2001: Sergei V Kotenko; Lara Izotova; Oleg Mirochnitchenko; E Esterova; Harold Dickensheets; Raymond P Donnelly; Sidney Pestka
Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(12):7096-103.
2001: Sergei V Kotenko; Lara Izotova; Oleg Mirochnitchenko; E Esterova; Harold Dickensheets; Raymond P Donnelly; Sidney Pestka
Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta ) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes.
The Journal of biological chemistry 2001;276(4):2725-32.
2000: Grant Gallagher; Harold Dickensheets; Joyce Eskdale; Lara Izotova; Oleg Mirochnitchenko; J D Peat; N Vazquez; S Pestka; Raymond P Donnelly; S V Kotenko
Cloning, expression and initial characterization of interleukin-19 (IL-19), a novel homologue of human interleukin-10 (IL-10).
Genes and immunity 2000;1(7):442-50.
2000: Christopher D Krause; Charles A Lunn; Lara Izotova; Oleg Mirochnitchenko; Sergei V Kotenko; Daniel Lundell; Satwant K Narula; Sidney Pestka
Signaling by covalent heterodimers of interferon-gamma. Evidence for one-sided signaling in the active tetrameric receptor complex.
The Journal of biological chemistry 2000;275(30):22995-3004.
2000: Sergei V Kotenko; S Saccani; Lara Izotova; Oleg Mirochnitchenko; Sidney Pestka
Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10).
Proceedings of the National Academy of Sciences of the United States of America 2000;97(4):1695-700.
2000: Sidney Pestka; L Lin; W Wu; Lara Izotova
Use of phosphorylation site tags in proteins.
Methods in enzymology 2000;327():594-613.
1999: Sidney Pestka; L Lin; W Wu; Lara Izotova
Introduction of protein kinase recognition sites into proteins: a review of their preparation, advantages, and applications.
Protein expression and purification 1999;17(2):203-14.
1999: BP Pollack; Sergei V Kotenko; W He; Lara Izotova; B L Barnoski; Sidney Pestka
The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity.
The Journal of biological chemistry 1999;274(44):31531-42.
1999: Sergei V Kotenko; Lara Izotova; Oleg Mirochnitchenko; C Lee; Sidney Pestka
The intracellular domain of interferon-alpha receptor 2c (IFN-alphaR2c) chain is responsible for Stat activation.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(9):5007-12.
1998: L Lin; SD Gillies; Y Lan; Lara Izotova; W Wu; J Schlom; Sidney Pestka
Construction of phosphorylatable chimeric monoclonal antibody CC49.
International journal of oncology 1998;13(1):115-20.
1997: Sergei V Kotenko; Christopher D Krause; Lara Izotova; BP Pollack; W Wu; Sidney Pestka
Identification and functional characterization of a second chain of the interleukin-10 receptor complex.
The EMBO journal 1997;16(19):5894-903.
1997: Sidney Pestka; Sergei V Kotenko; G Muthukumaran; Lara Izotova; J R Cook; G Garotta
The interferon gamma (IFN-gamma) receptor: a paradigm for the multichain cytokine receptor.
Cytokine & growth factor reviews 1997;8(3):189-206.
1996: Sergei V Kotenko; Lara Izotova; BP Pollack; G Muthukumaran; Kirsi Paukku; O Silvennoinen; J N Ihle; Sidney Pestka
Other kinases can substitute for Jak2 in signal transduction by interferon-gamma.
The Journal of biological chemistry 1996;271(29):17174-82.
1996: J R Cook; C M Cleary; T M Mariano; Lara Izotova; Sidney Pestka
Differential responsiveness of a splice variant of the human type I interferon receptor to interferons.
The Journal of biological chemistry 1996;271(23):13448-53.
1995: Sergei V Kotenko; Lara Izotova; BP Pollack; T M Mariano; R J Donnelly; G Muthukumaran; J R Cook; G Garotta; O Silvennoinen; J N Ihle
Interaction between the components of the interferon gamma receptor complex.
The Journal of biological chemistry 1995;270(36):20915-21.
1994: J Soh; T M Mariano; J K Lim; Lara Izotova; Oleg Mirochnitchenko; B Schwartz; Jerome A Langer; Sidney Pestka
Expression of a functional human type I interferon receptor in hamster cells: application of functional yeast artificial chromosome (YAC) screening.
The Journal of biological chemistry 1994;269(27):18102-10.
1994: P Wang; Lara Izotova; T M Mariano; R J Donnelly; Sidney Pestka
Construction and activity of phosphorylatable human interferon-alpha B2 and interferon-alpha A/D.
Journal of interferon research 1994;14(1):41-6.
1991: I I Shekhter; V P Beĭko; M T Bulenkov; O M Khodova; M A Kolevatykh; Lara Izotova; M I Lebedeva; A Iu Rudenskiĭ; S I Borukhov; V I Iurin
[Obtaining human recombinant (serine-17) beta-interferon by the method of oligonucleotide-directed mutagenesis and its expression in Escherichia coli].
Antibiotiki i khimioterapii͡a = Antibiotics and chemoterapy [sic] / Ministerstvo meditsinskoĭ i mikrobiologicheskoĭ promyshlennosti SSSR 1991;36(8):25-8.
1991: S V Mashko; A V Mochulsky; Sergei V Kotenko; M I Lebedeva; Alla Lapidus; N A Mochulskaya; Lara Izotova; VP Veiko; Y P Vinetsky; S A Ketlinsky
Use of a dual-origin temperature-controlled amplifiable replicon for optimization of human interleukin-1 beta synthesis in Escherichia coli.
Gene 1991;97(2):259-66.
1991: Andrei Alexenko; Lara Izotova; Sergey V Kostrov
Mapping of an epitope of human leukocyte alpha interferon A which is recognized by the murine monoclonal antibody NK2.
Biomedical science 1991;2(4):403-9.
1990: Andrei Alexenko; Lara Izotova
Reconstruction of an epitope capable of binding murine monoclonal antibodies NK2 within the sequence of human leukocyte interferon alpha F by site-directed mutagenesis.
Biochemical and biophysical research communications 1990;169(3):1061-7.
1990: S V Mashko; Sergei V Kotenko; V P Veĭko; M I Lebedeva; Alla Lapidus; A V Mochul'skiĭ; I I Shekhter; Lara Izotova; Iu P Vinetskiĭ; Vladimir G Debabov
[The use of the TGATG vector for expression in Escherichia coli cells of cloned cDNA copy of human interleukin-1beta gene].
Doklady Akademii nauk SSSR 1990;312(1):233-6.
1990: Alla Lapidus; A V Mochul'skii; S M Podkovyrov; M I Lebedeva; A A Antipin; Lara Izotova; O P Zagnit'ko; G S Komolova; A A Klesov; VP Veiko
Expression of the hAng gene in Escherichia coli; isolation and characterization of human recombinant Ser-(-1) angiogenin.
Biomedical science 1990;1(6):597-604.
1988: S I Borukhov; Lara Izotova; L P Korobitsin; V V Bumialis; A P Pivovarov
[Isolation and properties of monomeric and oligomeric forms of gene-engineered human leukocyte interferon alphaA from Pseudomonas sp].
Biokhimii͡a (Moscow, Russia) 1988;53(10):1718-27.
1988: S I Borukhov; Sergey V Kostrov; Lara Izotova; M N Orlova; A Ia Strongin
[Analysis of oligomeric forms of recombinant human leukocyte interferons].
Biokhimii͡a (Moscow, Russia) 1988;53(2):332-40.
1986: Sergey V Kostrov; Lara Izotova; S I Borukhov; A S Ryzhavskaia; A A Musatova
[Isolation and properties of human leukocyte interferon obtained by microbial synthesis].
Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology / Ministerstvo meditsinskoĭ promyshlennosti SSSR 1986;31(1):19-23.
1985: Sergey V Kostrov; Lara Izotova; M R Eremashvili; K I Galaktionov; V L Iurin
[Comparative immunochemical analysis of various human leukocyte interferons].
Biokhimii͡a (Moscow, Russia) 1985;50(12):2031-9.
1985: S I Borukhov; Lara Izotova; Sergey V Kostrov; S M Staroverov; A A Musatova
[Chromatographic properties of human leukocyte alpha-interferon A on sorbents with sepharose and silochrome matrices].
Biokhimii͡a (Moscow, Russia) 1985;50(9):1471-80.
1980: K A Shaginian; Lara Izotova; Iu V Iomantac; A Ia Strongin; V M Stepanov
[Metalloproteinase from Bacillus subtilis: - "intracellular" and extracellular enzymes].
Biokhimii͡a (Moscow, Russia) 1980;45(11):2083-95.
1980: K A Shaginian; Lara Izotova; A Ia Strongin; V M Stepanov
[Isolation of proteinase I from E. coli cells using affinty chromatography on bacitracin-Sepharose].
Biokhimii͡a (Moscow, Russia) 1980;45(4):695-703.