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Marja Jäättelä

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
14
Nylandsted, Jesper
12
Høyer-Hansen, Maria
10
Wissing, Dorte
8
Kallunki, Tuula
8
Fehrenbacher, Nicole
7
Bastholm, Lone
7
Egeblad, Mikala
7
Mathiasen, Ida Stenfeldt
7
Rohde, Mikkel
6
Gyrd-Hansen, Mads
6
Lademann, Ulrik
6
Farkas, Thomas
6
Elling, Folmer
4
Daugaard, Mads
4
Kroemer, Guido

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Publications

TOP 3
Corcelle Elisabeth A; Puustinen Pietri; Jäättelä Marja
Apoptosis and autophagy: Targeting autophagy signalling in cancer cells -'trick or treats'?
Farkas Thomas; Høyer-Hansen Maria; Jäättelä Marja
Identification of novel autophagy regulators by a luciferase-based assay for the kinetics of autophagic flux.
Cardoso Carla M P; Groth-Pedersen Line; Høyer-Hansen Maria; Kirkegaard Thomas; Corcelle Elizabeth; Andersen Jens S; Jäättelä Marja; Nylandsted Jesper
Depletion of kinesin 5B affects lysosomal distribution and stability and induces peri-nuclear accumulation of autophagosomes in cancer cells.

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All Publications

2009: Corcelle Elisabeth A; Puustinen Pietri; Jäättelä Marja
Apoptosis and autophagy: Targeting autophagy signalling in cancer cells -'trick or treats'?
The FEBS journal 2009;276(21):6084-96.
2009: Farkas Thomas; Høyer-Hansen Maria; Jäättelä Marja
Identification of novel autophagy regulators by a luciferase-based assay for the kinetics of autophagic flux.
Autophagy 2009;5(7):1018-25.
2009: Cardoso Carla M P; Groth-Pedersen Line; Høyer-Hansen Maria; Kirkegaard Thomas; Corcelle Elizabeth; Andersen Jens S; Jäättelä Marja; Nylandsted Jesper
Depletion of kinesin 5B affects lysosomal distribution and stability and induces peri-nuclear accumulation of autophagosomes in cancer cells.
PloS one 2009;4(2):e4424.
2008: Parry Mikko J; Alakoskela Juha-Matti I; Khandelia Himanshu; Kumar Subramanian Arun; Jäättelä Marja; Mahalka Ajay K; Kinnunen Paavo K J
High-affinity small molecule-phospholipid complex formation: binding of siramesine to phosphatidic acid.
Journal of the American Chemical Society 2008;130(39):12953-60.
2008: Fehrenbacher Nicole; Bastholm Lone; Kirkegaard-Sørensen Thomas; Rafn Bo; Bøttzauw Trine; Nielsen Christina; Weber Ekkehard; Shirasawa Senji; Kallunki Tuula; Jäättelä Marja
Sensitization to the lysosomal cell death pathway by oncogene-induced down-regulation of lysosome-associated membrane proteins 1 and 2.
Cancer research 2008;68(16):6623-33.
2008: Høyer-Hansen Maria; Jäättelä Marja
Autophagy: an emerging target for cancer therapy.
Autophagy 2008;4(5):574-80.
2008: Ostenfeld Marie Stampe; Høyer-Hansen Maria; Bastholm Lone; Fehrenbacher Nicole; Olsen Ole Dines; Groth-Pedersen Line; Puustinen Pietri; Kirkegaard-Sørensen Thomas; Nylandsted Jesper; Farkas Thomas; Jäättelä Marja
Anti-cancer agent siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation.
Autophagy 2008;4(4):487-99.
2008: Johansen Lars Dan; Naumanen Tiina; Knudsen Astrid; Westerlund Nina; Gromova Irina; Junttila Melissa; Nielsen Christina; Bøttzauw Trine; Tolkovsky Aviva; Westermarck Jukka; Coffey Eleanor T; Jäättelä Marja; Kallunki Tuula
IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration.
Journal of cell science 2008;121(Pt 6):854-64.
2008: Olesen Uffe Høgh; Christensen Mette Knak; Björkling Fredrik; Jäättelä Marja; Jensen Peter Buhl; Sehested Maxwell; Nielsen Søren Jensby
Anticancer agent CHS-828 inhibits cellular synthesis of NAD.
Biochemical and biophysical research communications 2008;367(4):799-804.
2007: Høyer-Hansen M; Jäättelä M
Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium.
Cell death and differentiation 2007;14(9):1576-82.
2007: Daugaard Mads; Rohde Mikkel; Jäättelä Marja
The heat shock protein 70 family: Highly homologous proteins with overlapping and distinct functions.
FEBS letters 2007;581(19):3702-10.
2007: Høyer-Hansen Maria; Jäättelä Marja
AMP-activated protein kinase: a universal regulator of autophagy?
Autophagy 2007;3(4):381-3.
2007: Daugaard Mads; Kirkegaard-Sørensen Thomas; Ostenfeld Marie Stampe; Aaboe Mads; Høyer-Hansen Maria; Orntoft Torben Falck; Rohde Mikkel; Jäättelä Marja
Lens epithelium-derived growth factor is an Hsp70-2 regulated guardian of lysosomal stability in human cancer.
Cancer research 2007;67(6):2559-67.
2007: Groth-Pedersen Line; Ostenfeld Marie Stampe; Høyer-Hansen Maria; Nylandsted Jesper; Jäättelä Marja
Vincristine induces dramatic lysosomal changes and sensitizes cancer cells to lysosome-destabilizing siramesine.
Cancer research 2007;67(5):2217-25.
2007: Høyer-Hansen Maria; Bastholm Lone; Szyniarowski Piotr; Campanella Michelangelo; Szabadkai György; Farkas Thomas; Bianchi Katiuscia; Fehrenbacher Nicole; Elling Folmer; Rizzuto Rosario; Mathiasen Ida Stenfeldt; Jäättelä Marja
Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2.
Molecular cell 2007;25(2):193-205.
2007: Nielsen Christina; Thastrup Jacob; Bøttzauw Trine; Jäättelä Marja; Kallunki Tuula
c-Jun NH2-terminal kinase 2 is required for Ras transformation independently of activator protein 1.
Cancer research 2007;67(1):178-85.
2006: Gyrd-Hansen Mads; Farkas Thomas; Fehrenbacher Nicole; Bastholm Lone; Høyer-Hansen Maria; Elling Folmer; Wallach David; Flavell Richard; Kroemer Guido; Nylandsted Jesper; Jäättelä Marja
Apoptosome-independent activation of the lysosomal cell death pathway by caspase-9.
Molecular and cellular biology 2006;26(21):7880-91.
2005: Kroemer Guido; Jäättelä Marja
Lysosomes and autophagy in cell death control.
Nature reviews. Cancer 2005;5(11):886-97.
2005: Ostenfeld Marie Stampe; Fehrenbacher Nicole; Høyer-Hansen Maria; Thomsen Christian; Farkas Thomas; Jäättelä Marja
Effective tumor cell death by sigma-2 receptor ligand siramesine involves lysosomal leakage and oxidative stress.
Cancer research 2005;65(19):8975-83.
2005: Høyer-Hansen M; Bastholm L; Mathiasen I S; Elling F; Jäättelä M
Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death.
Cell death and differentiation 2005;12(10):1297-309.
2005: Lerdrup M; Holmberg C; Dietrich N; Shaulian E; Herdegen T; Jäättelä M; Kallunki T
Depletion of the AP-1 repressor JDP2 induces cell death similar to apoptosis.
Biochimica et biophysica acta 2005;1745(1):29-37.
2005: Daugaard Mads; Jäättelä Marja; Rohde Mikkel
Hsp70-2 is required for tumor cell growth and survival.
Cell cycle (Georgetown, Tex.) 2005;4(7):877-80.
2005: Fehrenbacher Nicole; Jäättelä Marja
Lysosomes as targets for cancer therapy.
Cancer research 2005;65(8):2993-5.
2005: Rohde Mikkel; Daugaard Mads; Jensen Mette Hartvig; Helin Kristian; Nylandsted Jesper; Jäättelä Marja
Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms.
Genes & development 2005;19(5):570-82.
2005: Gehrmann M; Marienhagen J; Eichholtz-Wirth H; Fritz E; Ellwart J; Jäättelä M; Zilch T; Multhoff G
Dual function of membrane-bound heat shock protein 70 (Hsp70), Bag-4, and Hsp40: protection against radiation-induced effects and target structure for natural killer cells.
Cell death and differentiation 2005;12(1):38-51.
2004: Gyrd-Hansen Mads; Nylandsted Jesper; Jäättelä Marja
Heat shock protein 70 promotes cancer cell viability by safeguarding lysosomal integrity.
Cell cycle (Georgetown, Tex.) 2004;3(12):1484-5.
2004: Nylandsted J; Jäättelä M; Hoffmann E K; Pedersen S F
Heat shock protein 70 inhibits shrinkage-induced programmed cell death via mechanisms independent of effects on cell volume-regulatory membrane transport proteins.
Pflügers Archiv : European journal of physiology 2004;449(2):175-85.
2004: Nylandsted Jesper; Jäättelä Marja
[Heat shock protein 70: an important survival factor for cancer cells]
Ugeskrift for laeger 2004;166(37):3184-6.
2004: Nylandsted Jesper; Gyrd-Hansen Mads; Danielewicz Agnieszka; Fehrenbacher Nicole; Lademann Ulrik; Høyer-Hansen Maria; Weber Ekkehard; Multhoff Gabriele; Rohde Mikkel; Jäättelä Marja
Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization.
The Journal of experimental medicine 2004;200(4):425-35.
2004: Fehrenbacher Nicole; Gyrd-Hansen Mads; Poulsen Birgit; Felbor Ute; Kallunki Tuula; Boes Marianne; Weber Ekkehard; Leist Marcel; Jäättelä Marja
Sensitization to the lysosomal cell death pathway upon immortalization and transformation.
Cancer research 2004;64(15):5301-10.
2004: Seidelin Jakob B; Jäättelä Marja; Nielsen Ole Haagen
Continuous interferon-gamma or tumor necrosis factor-alpha exposure of enterocytes attenuates cell death responses.
Cytokine 2004;27(4-5):113-9.
2004: Bang Bo; Baadsgaard Ole; Skov Lone; Jäättelä Marja
Inhibitors of cysteine cathepsin and calpain do not prevent ultraviolet-B-induced apoptosis in human keratinocytes and HeLa cells.
Archives of dermatological research 2004;296(2):67-73.
2004: Jäättelä Marja
Multiple cell death pathways as regulators of tumour initiation and progression.
Oncogene 2004;23(16):2746-56.
2004: Dietrich N; Thastrup J; Holmberg C; Gyrd-Hansen M; Fehrenbacher N; Lademann U; Lerdrup M; Herdegen T; Jäättelä M; Kallunki T
JNK2 mediates TNF-induced cell death in mouse embryonic fibroblasts via regulation of both caspase and cathepsin protease pathways.
Cell death and differentiation 2004;11(3):301-13.
2004: Jäättelä M; Candé C; Kroemer G
Lysosomes and mitochondria in the commitment to apoptosis: a potential role for cathepsin D and AIF.
Cell death and differentiation 2004;11(2):135-6.
2004: Olsson Tomas; Hansson Oskar; Nylandsted Jesper; Jäättelä Marja; Smith Maj-Lis; Wieloch Tadeusz
Lack of neuroprotection by heat shock protein 70 overexpression in a mouse model of global cerebral ischemia.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 2004;154(4):442-9.
2003: Schmitt Elise; Parcellier Arnaud; Gurbuxani Sandeep; Cande Celine; Hammann Arlette; Morales Maria Celia; Hunt Clayton R; Dix David J; Kroemer Romano T; Giordanetto Fabrizio; Jäättelä Marja; Penninger Josef M; Pance Alena; Kroemer Guido; Garrido Carmen
Chemosensitization by a non-apoptogenic heat shock protein 70-binding apoptosis-inducing factor mutant.
Cancer research 2003;63(23):8233-40.
2003: Lademann Ulrik; Cain Kelvin; Gyrd-Hansen Mads; Brown David; Peters Dan; Jäättelä Marja
Diarylurea compounds inhibit caspase activation by preventing the formation of the active 700-kilodalton apoptosome complex.
Molecular and cellular biology 2003;23(21):7829-37.
2003: Frese Steffen; Schaper Manuela; Kuster Jan-Rasmus; Miescher Daniela; Jäättelä Marja; Buehler Thomas; Schmid Ralph A
Cell death induced by down-regulation of heat shock protein 70 in lung cancer cell lines is p53-independent and does not require DNA cleavage.
The Journal of thoracic and cardiovascular surgery 2003;126(3):748-54.
2003: Celis Julio E; Gromov Pavel; Gromova Irina; Moreira José M A; Cabezón Teresa; Ambartsumian Noona; Grigorian Mariam; Lukanidin Eugene; Thor Straten Per; Guldberg Per; Bartkova Jirina; Bartek Jiri; Lukas Jiri; Lukas Claudia; Lykkesfeldt Anne; Jäättelä Marja; Roepstorff Peter; Bolund Lars; Ørntoft Torben; Brünner Nils; Overgaard Jens; Sandelin Kerstin; Blichert-Toft Mogens; Mouridsen Henning; Rank Fritz E
Integrating proteomic and functional genomic technologies in discovery-driven translational breast cancer research.
Molecular & cellular proteomics : MCP 2003;2(6):369-77.
2003: Boya Patricia; Andreau Karine; Poncet Delphine; Zamzami Naoufal; Perfettini Jean-Luc; Metivier Didier; Ojcius David M; Jäättelä Marja; Kroemer Guido
Lysosomal membrane permeabilization induces cell death in a mitochondrion-dependent fashion.
The Journal of experimental medicine 2003;197(10):1323-34.
2003: Jäättelä Marja; Tschopp Jürg
Caspase-independent cell death in T lymphocytes.
Nature immunology 2003;4(5):416-23.
2003: Hansson Oskar; Nylandsted Jesper; Castilho Roger F; Leist Marcel; Jäättelä Marja; Brundin Patrik
Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progression.
Brain research 2003;970(1-2):47-57.
2002: Nylandsted Jesper; Wick Wolfgang; Hirt Ulrich A; Brand Karsten; Rohde Mikkel; Leist Marcel; Weller Michael; Jäättelä Marja
Eradication of glioblastoma, and breast and colon carcinoma xenografts by Hsp70 depletion.
Cancer research 2002;62(24):7139-42.
2002: Santoni-Rugiu Eric; Duro Dominique; Farkas Thomas; Mathiasen Ida S; Jäättelä Marja; Bartek Jiri; Lukas Jiri
E2F activity is essential for survival of Myc-overexpressing human cancer cells.
Oncogene 2002;21(42):6498-509.
2002: Mathiasen Ida Stenfeldt; Sergeev Igor N; Bastholm Lone; Elling Folmer; Norman Anthony W; Jäättelä Marja
Calcium and calpain as key mediators of apoptosis-like death induced by vitamin D compounds in breast cancer cells.
The Journal of biological chemistry 2002;277(34):30738-45.
2002: Holmberg Christian; Katz Sigal; Lerdrup Mads; Herdegen Thomas; Jäättelä Marja; Aronheim Ami; Kallunki Tuula
A novel specific role for I kappa B kinase complex-associated protein in cytosolic stress signaling.
The Journal of biological chemistry 2002;277(35):31918-28.
2002: Leist Marcel; Jäättelä Marja
Burning up TNF toxicity for cancer therapy.
Nature medicine 2002;8(7):667-8.
2002: Mathiasen Ida S; Jäättelä Marja
Triggering caspase-independent cell death to combat cancer.
Trends in molecular medicine 2002;8(5):212-20.
2002: Jäättelä Marja
Programmed cell death: many ways for cells to die decently.
Annals of medicine 2002;34(6):480-8.
2001: Gurbuxani S; Bruey J M; Fromentin A; Larmonier N; Parcellier A; Jäättelä M; Martin F; Solary E; Garrido C
Selective depletion of inducible HSP70 enhances immunogenicity of rat colon cancer cells.
Oncogene 2001;20(51):7478-85.
2001: Egeblad M; Mortensen O H; Jäättelä M
Truncated ErbB2 receptor enhances ErbB1 signaling and induces reversible, ERK-independent loss of epithelial morphology.
International journal of cancer. Journal international du cancer 2001;94(2):185-91.
2001: Ravagnan L; Gurbuxani S; Susin S A; Maisse C; Daugas E; Zamzami N; Mak T; Jäättelä M; Penninger J M; Garrido C; Kroemer G
Heat-shock protein 70 antagonizes apoptosis-inducing factor.
Nature cell biology 2001;3(9):839-43.
2001: Mathiasen I S; Hansen C M; Foghsgaard L; Jäättelä M
Sensitization to TNF-induced apoptosis by 1,25-dihydroxy vitamin D(3) involves up-regulation of the TNF receptor 1 and cathepsin B.
International journal of cancer. Journal international du cancer 2001;93(2):224-31.
2001: Foghsgaard L; Wissing D; Mauch D; Lademann U; Bastholm L; Boes M; Elling F; Leist M; Jäättelä M
Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor.
The Journal of cell biology 2001;153(5):999-1010.
2001: Lademann U; Kallunki T; Jäättelä M
A20 zinc finger protein inhibits TNF-induced apoptosis and stress response early in the signaling cascades and independently of binding to TRAF2 or 14-3-3 proteins.
Cell death and differentiation 2001;8(3):265-72.
2001: Karpanen T; Egeblad M; Karkkainen M J; Kubo H; Ylä-Herttuala S; Jäättelä M; Alitalo K
Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth.
Cancer research 2001;61(5):1786-90.
2001: Egeblad M; Mortensen O H; van Kempen L C; Jäättelä M
BIBX1382BS, but not AG1478 or PD153035, inhibits the ErbB kinases at different concentrations in intact cells.
Biochemical and biophysical research communications 2001;281(1):25-31.
2000: Nylandsted J; Rohde M; Brand K; Bastholm L; Elling F; Jäättelä M
Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(14):7871-6.
2000: Egeblad M; Jäättelä M
Cell death induced by TNF or serum starvation is independent of ErbB receptor signaling in MCF-7 breast carcinoma cells.
International journal of cancer. Journal international du cancer 2000;86(5):617-25.
2000: Nylandsted J; Brand K; Jäättelä M
Heat shock protein 70 is required for the survival of cancer cells.
Annals of the New York Academy of Sciences 2000;926():122-5.
1999: Larsen S S; Egeblad M; Jäättelä M; Lykkesfeldt A E
Acquired antiestrogen resistance in MCF-7 human breast cancer sublines is not accomplished by altered expression of receptors in the ErbB-family.
Breast cancer research and treatment 1999;58(1):41-56.
1999: Mathiasen I S; Lademann U; Jäättelä M
Apoptosis induced by vitamin D compounds in breast cancer cells is inhibited by Bcl-2 but does not involve known caspases or p53.
Cancer research 1999;59(19):4848-56.
1999: Jäättelä M
Heat shock proteins as cellular lifeguards.
Annals of medicine 1999;31(4):261-71.
1998: Jäättelä M; Wissing D; Kokholm K; Kallunki T; Egeblad M
Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases.
The EMBO journal 1998;17(21):6124-34.
1998: Wissing D; Mouritzen H; Jäättelä M
TNF-induced mitochondrial changes and activation of apoptotic proteases are inhibited by A20.
Free radical biology & medicine 1998;25(1):57-65.
1997: Klefstrom J; Arighi E; Littlewood T; Jäättelä M; Saksela E; Evan G I; Alitalo K
Induction of TNF-sensitive cellular phenotype by c-Myc involves p53 and impaired NF-kappaB activation.
The EMBO journal 1997;16(24):7382-92.
1997: Foghsgaard L; Jäättelä M
The ability of BHRF1 to inhibit apoptosis is dependent on stimulus and cell type.
Journal of virology 1997;71(10):7509-17.
1997: Wissing D; Mouritzen H; Egeblad M; Poirier G G; Jäättelä M
Involvement of caspase-dependent activation of cytosolic phospholipase A2 in tumor necrosis factor-induced apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(10):5073-7.
1996: Bellmann K; Jäättelä M; Wissing D; Burkart V; Kolb H
Heat shock protein hsp70 overexpression confers resistance against nitric oxide.
FEBS letters 1996;391(1-2):185-8.
1996: Karlseder J; Wissing D; Holzer G; Orel L; Sliutz G; Auer H; Jäättelä M; Simon M M
HSP70 overexpression mediates the escape of a doxorubicin-induced G2 cell cycle arrest.
Biochemical and biophysical research communications 1996;220(1):153-9.
1996: Jäättelä M; Mouritzen H; Elling F; Bastholm L
A20 zinc finger protein inhibits TNF and IL-1 signaling.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(3):1166-73.
1996: Wissing D; Jäättelä M
HSP27 and HSP70 increase the survival of WEHI-S cells exposed to hyperthermia.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 1996;12(1):125-38.
1995: Jäättelä M; Benedict M; Tewari M; Shayman J A; Dixit V M
Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells.
Oncogene 1995;10(12):2297-305.
1995: Jäättelä M
Over-expression of hsp70 confers tumorigenicity to mouse fibrosarcoma cells.
International journal of cancer. Journal international du cancer 1995;60(5):689-93.
1993: Jäättelä M
Overexpression of major heat shock protein hsp70 inhibits tumor necrosis factor-induced activation of phospholipase A2.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(8):4286-94.
1993: Jäättelä M; Wissing D
Heat-shock proteins protect cells from monocyte cytotoxicity: possible mechanism of self-protection.
The Journal of experimental medicine 1993;177(1):231-6.
1992: Jäättelä M; Wissing D; Bauer P A; Li G C
Major heat shock protein hsp70 protects tumor cells from tumor necrosis factor cytotoxicity.
The EMBO journal 1992;11(10):3507-12.
1992: Jäättelä M; Wissing D
Emerging role of heat shock proteins in biology and medicine.
Annals of medicine 1992;24(4):249-58.

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