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Howard Jacob

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Bryce A Schuler; Sasha Z Prisco; Howard J Jacob
Using whole exome sequencing to walk from clinical practice to research and back again.
Artur Rangel-Filho; Aron Geurts; Jozef Lazar; Carol Moreno Quinn; Howard J Jacob
Rab38 modulates proteinuria in model of hypertension-associated renal disease.
Mallikarjuna R Pabbidi; Marija Renic; Hurtis J Tullos; David R Harder; Howard J Jacob; Julio Juncos; Luis Juncos; Jozeph Lazar; Richard J Roman
Identification of a region of rat chromosome 1 that impairs the myogenic response and autoregulation of cerebral blood flow in fawn-hooded hypertensive rats.

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All Publications

2013: Bryce A Schuler; Sasha Z Prisco; Howard J Jacob
Using whole exome sequencing to walk from clinical practice to research and back again.
Circulation 2013;127(9):968-70.
2013: Artur Rangel-Filho; Aron Geurts; Jozef Lazar; Carol Moreno Quinn; Howard J Jacob
Rab38 modulates proteinuria in model of hypertension-associated renal disease.
Journal of the American Society of Nephrology : JASN 2013;24(2):283-92.
2013: Mallikarjuna R Pabbidi; Marija Renic; Hurtis J Tullos; David R Harder; Howard J Jacob; Julio Juncos; Luis Juncos; Jozeph Lazar; Richard J Roman
Identification of a region of rat chromosome 1 that impairs the myogenic response and autoregulation of cerebral blood flow in fawn-hooded hypertensive rats.
American journal of physiology. Heart and circulatory physiology 2013;304(2):H311-7.
2013: Chun Yang; Kwang Woo Ahn; Oliver Hummel; Howard J Jacob; Terry Kurth; Purushottam W Laud; Mingyu Liang; Pengyuan Liu; Carol Moreno Quinn; Paul O'Connor; Giannino Patone; Robert P Ryan; Meredith Skelton; Francesco C Stingo; Shirng-Wern Tsaih; Marina Vannucci; Allen W Cowley
Increased proliferative cells in the medullary thick ascending limb of the loop of Henle in the Dahl salt-sensitive rat.
Hypertension 2013;61(1):208-15.
2012: Stanley J F Laulederkind; Timothy F Lowry; Rajni Nigam; Victoria Petri; Melinda R Dwinell; G Thomas Hayman; Howard J Jacob; Jennifer R Smith; Shur-Jen Wang; Mary Shimoyama
Exploring genetic, genomic, and phenotypic data at the rat genome database.
Current protocols in bioinformatics / editoral board, Andreas D. Baxevanis ... [et al.] 2012;Chapter 1():Unit1.14.
2012: Michael J Flister; Matthew Hoffman; Jozef Lazar; Carol Moreno Quinn; Caitlin C O'Meara; Sasha Z Prisco; Albert Sarkis; Jaime Wendt-Andrae; Howard J Jacob
Identification of hypertension susceptibility loci on rat chromosome 12.
Hypertension 2012;60(4):942-8.
2012: Caitlin C O'Meara; William E Sweeney; Shirng-Wern Tsaih; Bing Xiao; Ellis D Avner; Matthew Hoffman; Howard J Jacob; Carol Moreno Quinn
Role of genetic modifiers in an orthologous rat model of ARPKD.
Physiological genomics 2012;44(15):741-53.
2012: Caitlin C O'Meara; Richard J Roman; Allison B Sarkis; Niloofar M Tabatabai; Haiyan Xu; R. K. Kothinti; Jozef Lazar; Michelle M Lutz; Carol Moreno Quinn; Matthew Hoffman; Howard J Jacob
A 4.1-Mb congenic region of Rf-4 contributes to glomerular permeability.
Journal of the American Society of Nephrology : JASN 2012;23(5):825-33.
2012: Leah C Solberg Woods; Brett C Woods; Sonia J Laurie; Caroline M Leitschuh; Howard J Jacob
Rat chromosome 8 confers protection against dyslipidemia caused by a high-fat/low-carbohydrate diet.
Journal of nutrigenetics and nutrigenomics 2012;5(2):81-93.
2012: Stanley J F Laulederkind; Timothy F Lowry; Rajni Nigam; Victoria Petri; Mary Shimoyama; Jennifer R Smith; Marek Tutaj; Shur-Jen Wang; Jeff de Pons; Melinda R Dwinell; G Thomas Hayman; Howard J Jacob
Ontology searching and browsing at the Rat Genome Database.
Database : the journal of biological databases and curation 2012;2012():bas016.
2011: Carol Moreno Quinn; Mathew Hoffman; Timothy J Stodola; Daniela N Didier; Jozef Lazar; Aron M Geurts; Paula E North; Howard J Jacob; Andrew S Greene
Creation and characterization of a renin knockout rat.
Hypertension 2011;57(3):614-9.
2011: Elizabeth A Worthey; Marjorie J Arca; Monica J Basehore; David P Bick; Benedetta B Bonacci; Ulrich Broeckel; James T Casper; Trivikram Dasu; Brennan Decker; Daniel Helbling; Martin J Hessner; Howard J Jacob; David A Margolis; Alan N Mayer; John M Routes; Jaime M Serpe; Grant D Syverson; Aoy Tomita-Mitchell; Michael R Tschannen; Regan L Veith; James W Verbsky; David P Dimmock
Making a definitive diagnosis: successful clinical application of whole exome sequencing in a child with intractable inflammatory bowel disease.
Genetics in medicine : official journal of the American College of Medical Genetics 2011;13(3):255-62.
2011: Alan N Mayer; David P Dimmock; Marjorie J Arca; David P Bick; James W Verbsky; Elizabeth A Worthey; Howard J Jacob; David A Margolis
A timely arrival for genomic medicine.
Genetics in medicine : official journal of the American College of Medical Genetics 2011;13(3):195-6.
2011: Victoria Petri; Mary Shimoyama; G Thomas Hayman; Jennifer R Smith; Marek Tutaj; Jeff de Pons; Melinda R Dwinell; Diane H Munzenmaier; Simon N Twigger; Howard J Jacob
The Rat Genome Database pathway portal.
Database : the journal of biological databases and curation 2011;2011():bar010.
2011: Stanley J F Laulederkind; Mary Shimoyama; G Thomas Hayman; Timothy F Lowry; Rajni Nigam; Victoria Petri; Jennifer R Smith; Shur-Jen Wang; Jeff de Pons; George Kowalski; Weisong Liu; Wes Rood; Diane H Munzenmaier; Melinda R Dwinell; Simon N Twigger; Howard J Jacob
The Rat Genome Database curation tool suite: a set of optimized software tools enabling efficient acquisition, organization, and presentation of biological data.
Database : the journal of biological databases and curation 2011;2011():bar002.
2010: Howard J Jacob; Jozef Lazar; Melinda R Dwinell; Carol Moreno Quinn; Aron M Geurts
Gene targeting in the rat: advances and opportunities.
Trends in genetics : TIG 2010;26(12):510-8.
2010: Tatjana Adamovic; Donna McAllister; Tao Wang; Dragan Adamovic; J Jordi Rowe; Carol Moreno; Josef Lazar; Howard J Jacob; Sonia L Sugg
Identification of novel carcinogen-mediated mammary tumor susceptibility loci in the rat using the chromosome substitution technique.
Genes, chromosomes & cancer 2010;49(11):1035-45.
2010: Haifeng Shao; David S Sinasac; Lindsay C Burrage; Craig A Hodges; Pamela J Supelak; Mark R Palmert; Carol Moreno; Allen W Cowley; Howard J Jacob; Joseph H Nadeau
Analyzing complex traits with congenic strains.
Mammalian genome : official journal of the International Mammalian Genome Society 2010;21(5-6):276-86.
2010: Aron M Geurts; Gregory J Cost; Séverine Rémy; Xiaoxia Cui; Laurent Tesson; Claire Usal; Séverine Ménoret; Howard J Jacob; Ignacio Anegon; Roland Buelow
Generation of gene-specific mutated rats using zinc-finger nucleases.
Methods in molecular biology (Clifton, N.J.) 2010;597():211-25.
2010: Elizabeth A Worthey; Alexander J Stoddard; Howard J Jacob
Sequencing of the rat genome and databases.
Methods in molecular biology (Clifton, N.J.) 2010;597():33-53.
2010: Howard J Jacob
The rat: a model used in biomedical research.
Methods in molecular biology (Clifton, N.J.) 2010;597():1-11.
2009: Mary Shimoyama; G Thomas Hayman; Stanley J F Laulederkind; Rajni Nigam; Timothy F Lowry; Victoria Petri; Jennifer R Smith; Shur-Jen Wang; Diane H Munzenmaier; Melinda R Dwinell; Simon N Twigger; Howard J Jacob
The rat genome database curators: who, what, where, why.
PLoS computational biology 2009;5(11):e1000582.
2009: Marcelo A Nobrega; Leah C Solberg Woods; Stewart Fleming; Howard J Jacob
Distinct genetic regulation of progression of diabetes and renal disease in the Goto-Kakizaki rat.
Physiological genomics 2009;39(1):38-46.
2009: Aron M Geurts; Gregory J Cost; Yevgeniy Freyvert; Bryan Zeitler; Jeffrey C Miller; Vivian M Choi; Shirin S Jenkins; Adam Wood; Xiaoxia Cui; Xiangdong Meng; Anna Vincent; Stephen Lam; Mieczyslaw Michalkiewicz; Rebecca Schilling; Jamie Foeckler; Shawn Kalloway; Hartmut Weiler; Séverine Ménoret; Ignacio Anegon; Gregory D Davis; Lei Zhang; Edward J Rebar; Philip D Gregory; Fyodor D Urnov; Howard J Jacob; Roland Buelow
Knockout rats via embryo microinjection of zinc-finger nucleases.
Science (New York, N.Y.) 2009;325(5939):433.
2009: Tatjana Adamovic; Donna McAllister; Victor Guryev; Xujing Wang; Jaime Wendt Andrae; Edwin Cuppen; Howard J Jacob; Sonia L Sugg
Microalterations of inherently unstable genomic regions in rat mammary carcinomas as revealed by long oligonucleotide array-based comparative genomic hybridization.
Cancer research 2009;69(12):5159-67.
2008: Jan Michael Williams; Albert Sarkis; Kimberly M Hoagland; Katherine Fredrich; Robert P Ryan; Carol Moreno Quinn; Bernardo Lopez; Jozef Lazar; Francisco J Fenoy; Mukut Sharma; Michael R Garrett; Howard J Jacob; Richard J Roman
Transfer of the CYP4A region of chromosome 5 from Lewis to Dahl S rats attenuates renal injury.
American journal of physiology. Renal physiology 2008;295(6):F1764-77.
2008: Tatjana Adamovic; Donna McAllister; J Jordi Rowe; Tao Wang; Howard J Jacob; Sonia L Sugg
Genetic mapping of mammary tumor traits to rat chromosome 10 using a novel panel of consomic rats.
Cancer genetics and cytogenetics 2008;186(1):41-8.
2008: Jozef Lazar; Howard J Jacob; Tetsuro Wakatsuki
Engineered heart tissue: high throughput platform for dissection of complex diseases.
Journal of cardiovascular translational research 2008;1(3):232-5.
2008: David L Mattson; Melinda R Dwinell; Andrew S Greene; Anne E Kwitek; Richard J Roman; Howard J Jacob; Allen W Cowley
Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal disease.
American journal of physiology. Renal physiology 2008;295(3):F837-42.
2008: Mingyu Liang; Norman H Lee; Hongying Wang; Andrew S Greene; Anne E Kwitek; Mary L Kaldunski; Truong V Luu; Bryan C Frank; Scott Bugenhagen; Howard J Jacob; Allen W Cowley
Molecular networks in Dahl salt-sensitive hypertension based on transcriptome analysis of a panel of consomic rats.
Physiological genomics 2008;34(1):54-64.
2008: Simon N Twigger; Kim D Pruitt; Xosé M Fernández-Suárez; Donna Karolchik; Kim C Worley; Donna R Maglott; Garth Brown; George Weinstock; Richard A Gibbs; Jim Kent; Ewan Birney; Howard J Jacob
What everybody should know about the rat genome and its online resources.
Nature genetics 2008;40(5):523-7.
2008: S Gilibert; A E Kwitek; N Hubner; M Tschannen; Howard J Jacob; Jean Sassard; Alain Bataillard
Effects of chromosome 17 on features of the metabolic syndrome in the Lyon hypertensive rat.
Physiological genomics 2008;33(2):212-7.
2008: Carol Moreno Quinn; Jozef Lazar; Howard J Jacob; Anne E Kwitek
Comparative genomics for detecting human disease genes.
Advances in genetics 2008;60():655-97.
2007: Matthew C Petersen; Jozef Lazar; Howard J Jacob; Tetsuro Wakatsuki
Tissue engineering: a new frontier in physiological genomics.
Physiological genomics 2007;32(1):28-32.
2007: David L Mattson; Melinda R Dwinell; Andrew S Greene; Anne E Kwitek; Richard J Roman; Allen W Cowley; Howard J Jacob
Chromosomal mapping of the genetic basis of hypertension and renal disease in FHH rats.
American journal of physiology. Renal physiology 2007;293(6):F1905-14.
2007: Carol Moreno Quinn; Mary L Kaldunski; Tao Wang; Richard J Roman; Andrew S Greene; Jozef Lazar; Howard J Jacob; Allen W Cowley
Multiple blood pressure loci on rat chromosome 13 attenuate development of hypertension in the Dahl S hypertensive rat.
Physiological genomics 2007;31(2):228-35.
2007: Ulrich Broeckel; Christian Hengstenberg; Bjoern Mayer; Karen Maresso; Daniel Gaudet; Ondrej Seda; Johanne Tremblay; Stephan Holmer; Jeanette Erdmann; Christian Glöckner; Michael Harrison; Lisa J Martin; Jeff T Williams; Gerd Schmitz; Günter A J Riegger; Howard J Jacob; Pavel Hamet; Heribert Schunkert
A locus on chromosome 10 influences C-reactive protein levels in two independent populations.
Human genetics 2007;122(1):95-102.
2007: Mieczyslaw Michalkiewicz; Teresa Michalkiewicz; Aron M Geurts; Richard J Roman; Glenn R Slocum; Oded Singer; Dorothee Weihrauch; Andrew S Greene; Mary L Kaldunski; Inder M Verma; Howard J Jacob; Allen W Cowley
Efficient transgenic rat production by a lentiviral vector.
American journal of physiology. Heart and circulatory physiology 2007;293(1):H881-94.
2007: Simon N Twigger; Mary Shimoyama; Susan Bromberg; Anne E Kwitek; Howard J Jacob
The Rat Genome Database, update 2007--easing the path from disease to data and back again.
Nucleic acids research 2007;35(Database issue):D658-62.
2006: Nancy E Schlick; Michael I Jensen-Seaman; Kimberly Orlebeke; Anne E Kwitek; Howard J Jacob; Jozef Lazar
Sequence analysis of the complete mitochondrial DNA in 10 commonly used inbred rat strains.
American journal of physiology. Cell physiology 2006;291(6):C1183-92.
2006: Mary Pat Kunert; Ines Drenjancevic-Peric; Melinda R Dwinell; Julian H Lombard; Allen W Cowley; Andrew S Greene; Anne E Kwitek; Howard J Jacob
Consomic strategies to localize genomic regions related to vascular reactivity in the Dahl salt-sensitive rat.
Physiological genomics 2006;26(3):218-25.
2006: John R Meurer; J Lustig; Howard J Jacob
Genetic aspects of the etiology and treatment of asthma.
Pediatric clinics of North America 2006;53(4):715-25.
2006: Irshad Ali; Parvaneh Rafiee; Walter J Hogan; Howard J Jacob; Richard A Komorowski; George B Haasler; Reza Shaker
Dickkopf homologs in squamous mucosa of esophagitis patients are overexpressed compared with Barrett's patients and healthy controls.
The American journal of gastroenterology 2006;101(7):1437-48.
2006: Richard J Roman; Kimberly M Hoagland; Bernardo Lopez; Anne E Kwitek; Michael R Garrett; John P Rapp; Jozef Lazar; Howard J Jacob; Albert Sarkis
Characterization of blood pressure and renal function in chromosome 5 congenic strains of Dahl S rats.
American journal of physiology. Renal physiology 2006;290(6):F1463-71.
2006: Bernardo López; Robert P Ryan; Carol Moreno Quinn; Albert Sarkis; Jozef Lazar; Abraham P Provoost; Howard J Jacob; Richard J Roman
Identification of a QTL on chromosome 1 for impaired autoregulation of RBF in fawn-hooded hypertensive rats.
American journal of physiology. Renal physiology 2006;290(5):F1213-21.
2006: Anne E Kwitek; Howard J Jacob; John E Baker; Melinda R Dwinell; Hubert V Forster; Andrew S Greene; Mary Pat Kunert; Julian H Lombard; David L Mattson; Kirkwood A Pritchard; Richard J Roman; Peter Tonellato; Allen W Cowley
BN phenome: detailed characterization of the cardiovascular, renal, and pulmonary systems of the sequenced rat.
Physiological genomics 2006;25(2):303-13.
2006: Sandra van Dijk; Patricia A C Specht; Jozef Lazar; Howard J Jacob; Abraham P Provoost
Synergistic QTL interactions between Rf-1 and Rf-3 increase renal damage susceptibility in double congenic rats.
Kidney international 2006;69(8):1369-76.
2006: Renae L Malek; Hong-ying Wang; Anne E Kwitek; Andrew S Greene; Nirmal K Bhagabati; Gretta Borchardt; Lisa Cahill; Tracey Currier; Bryan Frank; Xianping Fu; Michael Hasinoff; Eleanor Howe; Noah E Letwin; Truong V Luu; Alexander Saeed; Hedieh Sajadi; Steven L Salzberg; Razvan Sultana; Mathangi Thiagarajan; Jennifer Tsai; Kathleen Veratti; Joseph White; John Quackenbush; Howard J Jacob; Norman H Lee
Physiogenomic resources for rat models of heart, lung and blood disorders.
Nature genetics 2006;38(2):234-9.
2006: Xujing Wang; Shuang Jia; Lisa Meyer; Bixia Xiang; Li-Yen Chen; Nan Jiang; Carol Moreno Quinn; Howard J Jacob; Soumitra Ghosh; Martin J Hessner
Comprehensive quality control utilizing the prehybridization third-dye image leads to accurate gene expression measurements by cDNA microarrays.
BMC bioinformatics 2006;7():378.
2006: Sandra van Dijk; Patricia A C Specht; Jozef Lazar; Howard J Jacob; Abraham P Provoost
Absence of an interaction between the Rf-1 and Rf-5 QTLs influencing susceptibility to renal damage in rats.
Nephron. Experimental nephrology 2006;104(3):e96-e102.
2005: Jozef Lazar; Carol Moreno Quinn; Howard J Jacob; Anne E Kwitek
Impact of genomics on research in the rat.
Genome research 2005;15(12):1717-28.
2005: Sandra van Dijk; Patricia A C Specht; Michelle M Lutz; Jozef Lazar; Howard J Jacob; Abraham P Provoost
Interaction between Rf-1 and Rf-4 quantitative trait loci increases susceptibility to renal damage in double congenic rats.
Kidney international 2005;68(6):2462-72.
2005: Melinda R Dwinell; Hubert V Forster; J Petersen; A Rider; Mary Pat Kunert; Allen W Cowley; Howard J Jacob
Genetic determinants on rat chromosome 6 modulate variation in the hypercapnic ventilatory response using consomic strains.
Journal of applied physiology (Bethesda, Md. : 1985) 2005;98(5):1630-8.
2005: David L Mattson; Mary Pat Kunert; Richard J Roman; Howard J Jacob; Allen W Cowley
Substitution of chromosome 1 ameliorates L-NAME hypertension and renal disease in the fawn-hooded hypertensive rat.
American journal of physiology. Renal physiology 2005;288(5):F1015-22.
2005: Yang Shi; William Hutchins; Hitoshi Ogawa; Chung-Che Chang; Kirkwood A Pritchard; Chenyang Zhang; Pawjai Khampang; Jozef Lazar; Howard J Jacob; Parvaneh Rafiee; John E Baker
Increased resistance to myocardial ischemia in the Brown Norway vs. Dahl S rat: role of nitric oxide synthase and Hsp90.
Journal of molecular and cellular cardiology 2005;38(4):625-35.
2005: Artur Rangel-Filho; Mukut Sharma; Yvonne H Datta; Carol Moreno Quinn; Richard J Roman; Yoshiki Iwamoto; Abraham P Provoost; Jozef Lazar; Howard J Jacob
RF-2 gene modulates proteinuria and albuminuria independently of changes in glomerular permeability in the fawn-hooded hypertensive rat.
Journal of the American Society of Nephrology : JASN 2005;16(4):852-6.
2005: Marcus Fischer; Ulrich Broeckel; Stephan Holmer; Andrea Baessler; Christian Hengstenberg; Bjoern Mayer; Jeanette Erdmann; Gernot Klein; Günter A J Riegger; Howard J Jacob; Heribert Schunkert
Distinct heritable patterns of angiographic coronary artery disease in families with myocardial infarction.
Circulation 2005;111(7):855-62.
2005: Carol Moreno Quinn; Kathleen Kennedy; Jaime Wendt Andrae; Howard J Jacob
Genome-wide scanning with SSLPs in the rat.
Methods in molecular medicine 2005;108():131-8.
2005: Sandra van Dijk; Patricia A C Specht; Jozef Lazar; Howard J Jacob; Abraham P Provoost
Renal damage susceptibility and autoregulation in RF-1 and RF-5 congenic rats.
Nephron. Experimental nephrology 2005;101(2):e59-66.
2005: Andrea Baessler; Michael Hasinoff; Marcus Fischer; Wibke Reinhard; Gabriele E Sonnenberg; Michael Olivier; Jeanette Erdmann; Heribert Schunkert; Angela Doering; Howard J Jacob; Anthony G Comuzzie; Ahmed H Kissebah; Anne E Kwitek
Genetic linkage and association of the growth hormone secretagogue receptor (ghrelin receptor) gene in human obesity.
Diabetes 2005;54(1):259-67.
2004: Marijo Bilusic; Alain Bataillard; Michael R Tschannen; Li Gao; Nadia E Barreto; Madeleine Vincent; Tao Wang; Howard J Jacob; Jean Sassard; Anne E Kwitek
Mapping the genetic determinants of hypertension, metabolic diseases, and related phenotypes in the lyon hypertensive rat.
Hypertension 2004;44(5):695-701.
2004: Mieczyslaw Michalkiewicz; Teresa Michalkiewicz; Ruth A Ettinger; Elizabeth A Rutledge; Jessica M Fuller; Daniel H Moralejo; Brian Van Yserloo; Armand J MacMurray; Anne E Kwitek; Howard J Jacob; Eric S Lander; Ake Lernmark
Transgenic rescue demonstrates involvement of the Ian5 gene in T cell development in the rat.
Physiological genomics 2004;19(2):228-32.
2004: Allen W Cowley; M Liang; Richard J Roman; Andrew S Greene; Howard J Jacob
Consomic rat model systems for physiological genomics.
Acta physiologica Scandinavica 2004;181(4):585-92.
2004: Anne E Kwitek; Jo Gullings-Handley; Jiaming Yu; Danilo C Carlos; Kimberly Orlebeke; Jeff Nie; Jeffrey Eckert; Angela Lemke; Jaime Wendt Andrae; Susan Bromberg; Dean Pasko; Dan Chen; Todd E Scheetz; Thomas L Casavant; M Bento Soares; Val C Sheffield; Peter Tonellato; Howard J Jacob
High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.
Genome research 2004;14(4):750-7.
2004: Simon N Twigger; Jeff Nie; Victor Ruotti; Jiaming Yu; Dan Chen; Dawei Li; Jedidiah Mathis; Vijay Narayanasamy; Gopal R Gopinath; Dean Pasko; Mary Shimoyama; Norberto De La Cruz; Susan Bromberg; Anne E Kwitek; Howard J Jacob; Peter Tonellato
Integrative genomics: in silico coupling of rat physiology and complex traits with mouse and human data.
Genome research 2004;14(4):651-60.
2004: Michael I Jensen-Seaman; Terrence S Furey; Bret Payseur; Yontao Lu; Krishna M Roskin; Chin-Fu Chen; Michael A Thomas; David Haussler; Howard J Jacob
Comparative recombination rates in the rat, mouse, and human genomes.
Genome research 2004;14(4):528-38.
2004: Marcelo A Nobrega; Stewart Fleming; Richard J Roman; Masahide Shiozawa; Nancy E Schlick; Jozef Lazar; Howard J Jacob
Initial characterization of a rat model of diabetic nephropathy.
Diabetes 2004;53(3):735-42.
2004: David L Mattson; Mary Pat Kunert; Mary L Kaldunski; Andrew S Greene; Richard J Roman; Howard J Jacob; Allen W Cowley
Influence of diet and genetics on hypertension and renal disease in Dahl salt-sensitive rats.
Physiological genomics 2004;16(2):194-203.
2004: Allen W Cowley; Richard J Roman; Howard J Jacob
Application of chromosomal substitution techniques in gene-function discovery.
The Journal of physiology 2004;554(Pt 1):46-55.
2003: Joseph A Cioffi; Christy B Erbe; Richard Raphael; Anne E Kwitek; Umesh K Tiwari; Howard J Jacob; Paul Popper; P Ashley Wackym
Expression of G-protein alpha subunit genes in the vestibular periphery of Rattus norvegicus and their chromosomal mapping.
Acta oto-laryngologica 2003;123(9):1027-34.
2003: Daniel H Moralejo; Hyunhee A Park; Sara J Speros; Armand J MacMurray; Anne E Kwitek; Howard J Jacob; Eric S Lander; Ake Lernmark
Genetic dissection of lymphopenia from autoimmunity by introgression of mutated Ian5 gene onto the F344 rat.
Journal of autoimmunity 2003;21(4):315-24.
2003: Carol Moreno Quinn; Pierre Dumas; Mary L Kaldunski; Peter Tonellato; Andrew S Greene; Richard J Roman; Qunli Cheng; Zhitao Wang; Howard J Jacob; Allen W Cowley
Genomic map of cardiovascular phenotypes of hypertension in female Dahl S rats.
Physiological genomics 2003;15(3):243-57.
2003: Yvonne H Datta; Francisca C Wu; Pierre C Dumas; Artur Rangel-Filho; Milton W Datta; Gang Ning; Brian C Cooley; Rebecca R Majewski; Abraham P Provoost; Howard J Jacob
Genetic mapping and characterization of the bleeding disorder in the fawn-hooded hypertensive rat.
Thrombosis and haemostasis 2003;89(6):1031-42.
2003: Martin J Hessner; Xujing Wang; Shehnaz Khan; Lisa Meyer; Michael J Schlicht; Jennifer Tackes; Milton W Datta; Howard J Jacob; Soumitra Ghosh
Use of a three-color cDNA microarray platform to measure and control support-bound probe for improved data quality and reproducibility.
Nucleic acids research 2003;31(11):e60.
2002: Jeffrey Tseng; Christy B Erbe; Anne E Kwitek; Howard J Jacob; Paul Popper; P Ashley Wackym
Radiation hybrid mapping of five muscarinic acetylcholine receptor subtype genes in Rattus norvegicus.
Hearing research 2002;174(1-2):86-92.
2002: Armand J MacMurray; Daniel H Moralejo; Anne E Kwitek; Elizabeth A Rutledge; Brian Van Yserloo; Paul Gohlke; Sara J Speros; Ben Snyder; Jonathan Schaefer; Sabine Bieg; Jianjie Jiang; Ruth A Ettinger; Jessica Fuller; Terri L Daniels; Anna Pettersson; Kimberly Orlebeke; Bruce Birren; Howard J Jacob; Eric S Lander; Ake Lernmark
Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene.
Genome research 2002;12(7):1029-39.
2002: Mingyu Liang; Baozhi Yuan; Elizabeth Rute; Andrew S Greene; Ai-Ping Zou; Paulo Soares; Gregory D MCQuestion; Glenn R Slocum; Howard J Jacob; Allen W Cowley
Renal medullary genes in salt-sensitive hypertension: a chromosomal substitution and cDNA microarray study.
Physiological genomics 2002;8(2):139-49.
2002: Abraham P Provoost; Masahide Shiozawa; Richard P E van Dokkum; Howard J Jacob
Transfer of the Rf-1 region from FHH onto the ACI background increases susceptibility to renal impairment.
Physiological genomics 2002;8(2):123-9.
2002: Ulrich Broeckel; Christian Hengstenberg; Björn Mayer; Stephan Holmer; Lisa J Martin; Anthony G Comuzzie; John C Blangero; Peter Nürnberg; André Reis; Günter A J Riegger; Howard J Jacob; Heribert Schunkert
A comprehensive linkage analysis for myocardial infarction and its related risk factors.
Nature genetics 2002;30(2):210-4.
2002: Howard J Jacob; Anne E Kwitek
Rat genetics: attaching physiology and pharmacology to the genome.
Nature reviews. Genetics 2002;3(1):33-42.
2002: Yasuhiro Kita; Masahide Shiozawa; Weihong Jin; Rebecca R Majewski; Joseph C Besharse; Andrew S Greene; Howard J Jacob
Implications of circadian gene expression in kidney, liver and the effects of fasting on pharmacogenomic studies.
Pharmacogenetics 2002;12(1):55-65.
2001: M Stoll; Allen W Cowley; Peter Tonellato; Andrew S Greene; Mary L Kaldunski; Richard J Roman; Pierre Dumas; Nicholas J Schork; Z Wang; Howard J Jacob
A genomic-systems biology map for cardiovascular function.
Science (New York, N.Y.) 2001;294(5547):1723-6.
2001: Anne E Kwitek; Peter Tonellato; Dan Chen; Jo Gullings-Handley; Y S Cheng; Simon N Twigger; Todd E Scheetz; Thomas L Casavant; M Stoll; Marcelo A Nobrega; Masahide Shiozawa; M Bento Soares; Val C Sheffield; Howard J Jacob
Automated construction of high-density comparative maps between rat, human, and mouse.
Genome research 2001;11(11):1935-43.
2001: Sarah Zangen; Chana Yagil; David H Zangen; A Ornoy; Howard J Jacob; Yoram Yagil
The newly inbred cohen diabetic rat: a nonobese normolipidemic genetic model of diet-induced type 2 diabetes expressing sex differences.
Diabetes 2001;50(11):2521-9.
2001: Anthony G Comuzzie; T Funahashi; Gabriele E Sonnenberg; Lisa J Martin; Howard J Jacob; A E Black; D Maas; M Takahashi; S Kihara; S Tanaka; Y Matsuzawa; John C Blangero; D Cohen; Ahmed H Kissebah
The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome.
The Journal of clinical endocrinology and metabolism 2001;86(9):4321-5.
2001: Jeffrey Tseng; AE Kwitek-Black; Christy B Erbe; Paul Popper; Howard J Jacob; P Ashley Wackym
Radiation hybrid mapping of 11 alpha and beta nicotinic acetylcholine receptor genes in Rattus norvegicus.
Brain research. Molecular brain research 2001;91(1-2):169-73.
2001: M Stoll; Howard J Jacob
Genetic rat models of hypertension: relationship to human hypertension.
Current hypertension reports 2001;3(2):157-64.
2001: Allen W Cowley; Richard J Roman; Mary L Kaldunski; Pierre Dumas; Jeffrey G Dickhout; Andrew S Greene; Howard J Jacob
Brown Norway chromosome 13 confers protection from high salt to consomic Dahl S rat.
Hypertension 2001;37(2 Pt 2):456-61.
2001: AE Kwitek-Black; Howard J Jacob
The use of designer rats in the genetic dissection of hypertension.
Current hypertension reports 2001;3(1):12-8.
2000: Ahmed H Kissebah; Gabriele E Sonnenberg; Joel Myklebust; M Goldstein; Karl W Broman; R G James; J A Marks; Glenn R Krakower; Howard J Jacob; J Weber; L Martin; John C Blangero; Anthony G Comuzzie
Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(26):14478-83.
2000: Masahide Shiozawa; Abraham P Provoost; Richard P E van Dokkum; Rebecca R Majewski; Howard J Jacob
Evidence of gene-gene interactions in the genetic susceptibility to renal impairment after unilateral nephrectomy.
Journal of the American Society of Nephrology : JASN 2000;11(11):2068-78.
2000: X Zhu; C A McKenzie; T Forrester; D A Nickerson; Ulrich Broeckel; H Schunkert; A Doering; Howard J Jacob; Richard S Cooper; M J Rieder
Localization of a small genomic region associated with elevated ACE.
American journal of human genetics 2000;67(5):1144-53.
2000: Richard P E van Dokkum; Howard J Jacob; Abraham P Provoost
Blood pressure and the susceptibility to renal damage after unilateral nephrectomy and L-NAME-induced hypertension in rats.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2000;15(9):1337-43.
2000: Allen W Cowley; M Stoll; Andrew S Greene; Mary L Kaldunski; Richard J Roman; Peter Tonellato; Nicholas J Schork; Pierre Dumas; Howard J Jacob
Genetically defined risk of salt sensitivity in an intercross of Brown Norway and Dahl S rats.
Physiological genomics 2000;2(3):107-15.
2000: M Stoll; AE Kwitek-Black; Allen W Cowley; E L Harris; S B Harrap; J E Krieger; M P Printz; Abraham P Provoost; Jean Sassard; Howard J Jacob
New target regions for human hypertension via comparative genomics.
Genome research 2000;10(4):473-82.
2000: John E Baker; Eugene Konorev; Garrett J Gross; William M Chilian; Howard J Jacob
Resistance to myocardial ischemia in five rat strains: is there a genetic component of cardioprotection?
American journal of physiology. Heart and circulatory physiology 2000;278(4):H1395-400.
2000: Marcelo A Nobrega; Masahide Shiozawa; G Koike; Howard J Jacob; Joseph M Miano
Gene structure and chromosomal mapping of the rat smooth muscle calponin gene.
Mammalian genome : official journal of the International Mammalian Genome Society 2000;11(2):115-9.
1999: Howard J Jacob
Functional genomics and rat models.
Genome research 1999;9(11):1013-6.
1999: M Glickman; R L Malek; AE Kwitek-Black; Howard J Jacob; N H Lee
Molecular cloning, tissue-specific expression, and chromosomal localization of a novel nerve growth factor-regulated G-protein- coupled receptor, nrg-1.
Molecular and cellular neurosciences 1999;14(2):141-52.
1999: RG Steen; AE Kwitek-Black; C Glenn; Jo Gullings-Handley; WJ Van Etten; O S Atkinson; D Appel; Simon N Twigger; M Muir; T Mull; M Granados; M Kissebah; K Russo; R Crane; M Popp; M Peden; T Matise; D M Brown; J Lu; Stephen Kingsmore; Peter Tonellato; Steve Rozen; DK Slonim; P Young; Howard J Jacob
A high-density integrated genetic linkage and radiation hybrid map of the laboratory rat.
Genome research 1999;9(6):AP1-8, insert.
1999: Claude Szpirer; Josiane Szpirer; Pascale Van Vooren; F Tissir; Jason Simon; G Koike; Howard J Jacob; Eric S Lander; Khalil Helou; Karin Klinga-Levan; Göran Levan
Gene-based anchoring of the rat genetic linkage and cytogenetic maps.
Transplantation proceedings 1999;31(3):1541-3.
1999: Richard P E van Dokkum; C W Sun; Abraham P Provoost; Howard J Jacob; Richard J Roman
Altered renal hemodynamics and impaired myogenic responses in the fawn-hooded rat.
The American journal of physiology 1999;276(3 Pt 2):R855-63.
1999: Suwen Wei; Kaichun Wei; Daniel H Moralejo; Tomoe Ogino; G Koike; Howard J Jacob; K Sugiura; Yoshiyuki Sasaki; Takahisa Yamada; Kozo Matsumoto
Mapping and characterization of quantitative trait loci for non-insulin-dependent diabetes mellitus with an improved genetic map in the Otsuka Long-Evans Tokushima fatty rat.
Mammalian genome : official journal of the International Mammalian Genome Society 1999;10(3):249-58.
1999: G Koike; Jean-Daniel Chiche; Masahide Shiozawa; Jason Simon; Josiane Szpirer; Howard J Jacob; Claude Szpirer; Kenneth D Bloch
Localization of rat genes in the nitric oxide signaling pathway: candidates for the pathogenesis of complex diseases.
Mammalian genome : official journal of the International Mammalian Genome Society 1999;10(1):71-3.
1999: Richard P E van Dokkum; Magdalena Alonso-Galicia; Abraham P Provoost; Howard J Jacob; Richard J Roman
Impaired autoregulation of renal blood flow in the fawn-hooded rat.
The American journal of physiology 1999;276(1 Pt 2):R189-96.
1998: Daniel H Moralejo; Suwen Wei; Kaichun Wei; Sarah Zangen; G Koike; Howard J Jacob; T Hirashima; K Kawano; K Sugiura; Yoshiyuki Sasaki; Tomoe Ogino; Takahisa Yamada; Kozo Matsumoto
Identification of quantitative trait loci for non-insulin-dependent diabetes mellitus that interact with body weight in the Otsuka Long-Evans Tokushima Fatty rat.
Proceedings of the Association of American Physicians 1998;110(6):545-58.
1998: Claude Szpirer; Josiane Szpirer; Pascale Van Vooren; F Tissir; Jason Simon; G Koike; Howard J Jacob; Eric S Lander; Khalil Helou; Karin Klinga-Levan; Göran Levan
Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution.
Mammalian genome : official journal of the International Mammalian Genome Society 1998;9(9):721-34.
1998: D M Brown; T C Matise; G Koike; Jason Simon; E S Winer; S Zangen; M G McLaughlin; Masahide Shiozawa; O S Atkinson; J R Hudson; Aravinda Chakravarti; Eric S Lander; Howard J Jacob
An integrated genetic linkage map of the laboratory rat.
Mammalian genome : official journal of the International Mammalian Genome Society 1998;9(7):521-30.
1998: U Broeckel; M Shiozawa; A H Kissebah; Abraham P Provoost; Howard J Jacob
Susceptibility genes for end-organ damage. New strategies to understand diabetic and hypertensive nephropathy.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1998;13(4):840-2.
1998: Ela W Knapik; A Goodman; Marc Ekker; Mario Chevrette; J Delgado; Stephan Neuhauss; N Shimoda; Wolfgang Driever; Mark C Fishman; Howard J Jacob
A microsatellite genetic linkage map for zebrafish (Danio rerio).
Nature genetics 1998;18(4):338-43.
1998: Sabine Bieg; G Koike; Jianjie Jiang; Lindy S Klaff; Anna Pettersson; Armand J MacMurray; Howard J Jacob; Eric S Lander; Ake Lernmark
Genetic isolation of iddm 1 on chromosome 4 in the biobreeding (BB) rat.
Mammalian genome : official journal of the International Mammalian Genome Society 1998;9(4):324-6.
1998: D M Brown; Richard P E van Dokkum; M R Korte; M G McLauglin; Masahide Shiozawa; Howard J Jacob; Abraham P Provoost
Genetic control of susceptibility for renal damage in hypertensive fawn-hooded rats.
Renal failure 1998;20(2):407-11.
1998: J Jiang; Howard J Jacob
EbEST: an automated tool using expressed sequence tags to delineate gene structure.
Genome research 1998;8(3):268-75.
1998: Richard P E van Dokkum; Howard J Jacob; Abraham P Provoost
Genetic differences define severity of renal damage after L-NAME-induced hypertension in rats.
Journal of the American Society of Nephrology : JASN 1998;9(3):363-71.
1998: G Koike; Joseph M Miano; P Vanvooren; Masahide Shiozawa; Claude Szpirer; Howard J Jacob
Mapping of the rat SM22 gene to chromosome 8q24: a candidate for high blood pressure and cardiac hypertrophy.
Mammalian genome : official journal of the International Mammalian Genome Society 1998;9(1):76-7.
1997: Richard P E van Dokkum; Howard J Jacob; Abraham P Provoost
Difference in susceptibility of developing renal damage in normotensive fawn-hooded (FHL) and August x Copenhagen Irish (ACI) rats after N(omega)-nitro-L-arginine methyl ester induced hypertension.
American journal of hypertension 1997;10(10 Pt 1):1109-16.
1997: Claude Szpirer; Josiane Szpirer; P Vanvooren; Michèle Rivière; B Maget; Michal Svoboda; Masahide Shiozawa; Jason Simon; Howard J Jacob; G Koike
Localization of the rat genes encoding glucagon, glucagon receptor, and insulin receptor, candidates for diabetes mellitus susceptibility loci.
Mammalian genome : official journal of the International Mammalian Genome Society 1997;8(8):586-8.
1997: J Jiang; D E Stec; Heather A Drummond; Jason Simon; G Koike; Howard J Jacob; Richard J Roman
Transfer of a salt-resistant renin allele raises blood pressure in Dahl salt-sensitive rats.
Hypertension 1997;29(2):619-27.
1996: Ela W Knapik; A Goodman; O S Atkinson; C T Roberts; Masahide Shiozawa; C U Sim; S Weksler-Zangen; M R Trolliet; C Futrell; B A Innes; G Koike; M G McLaughlin; L Pierre; Jason Simon; E Vilallonga; M Roy; P W Chiang; Mark C Fishman; Wolfgang Driever; Howard J Jacob
A reference cross DNA panel for zebrafish (Danio rerio) anchored with simple sequence length polymorphisms.
Development (Cambridge, England) 1996;123():451-60.
1996: N J Schork; S P Nath; Klaus Lindpaintner; Howard J Jacob
Extensions to quantitative trait locus mapping in experimental organisms.
Hypertension 1996;28(6):1104-11.
1996: G Koike; Pascale Van Vooren; Masahide Shiozawa; J Galli; L S Li; A Glaser; A Balasubramanyam; L J Brown; Holger Luthman; Claude Szpirer; M J MacDonald; Howard J Jacob
Genetic mapping and chromosome localization of the rat mitochondrial glycerol-3-phosphate dehydrogenase gene, a candidate for non-insulin-dependent diabetes mellitus.
Genomics 1996;38(1):96-9.
1996: D E Stec; M R Trolliet; José E Krieger; Howard J Jacob; Richard J Roman
Renal cytochrome P4504A activity and salt sensitivity in spontaneously hypertensive rats.
Hypertension 1996;27(6):1329-36.
1996: Jason Simon; G Deshmukh; Fergus J. Couch; Sofia D Merajver; Barbara L Weber; Pascale Van Vooren; F Tissil; Josiane Szpirer; Claude Szpirer; Seth L Alper; Howard J Jacob; Frank C Brosius III
Chromosomal mapping of the rat Slc4a family of anion exchanger genes, Ae1, Ae2, and Ae3.
Mammalian genome : official journal of the International Mammalian Genome Society 1996;7(5):380-2.
1996: D M Brown; A P Provoost; Mark J Daly; Eric S Lander; Howard J Jacob
Renal disease susceptibility and hypertension are under independent genetic control in the fawn-hooded rat.
Nature genetics 1996;12(1):44-51.
1996: J Galli; L S Li; A Glaser; C G Ostenson; H Jiao; Hossein Fakhrai-Rad; Howard J Jacob; E S Lander; Holger Luthman
Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat.
Nature genetics 1996;12(1):31-7.
1995: G Koike; E S Winer; M Horiuchi; D M Brown; Claude Szpirer; V J Dzau; Howard J Jacob
Cloning, characterization, and genetic mapping of the rat type 2 angiotensin II receptor gene.
Hypertension 1995;26(6 Pt 1):998-1002.
1995: G Koike; Howard J Jacob; José E Krieger; Claude Szpirer; M R Hoehe; M Horiuchi; Victor J Dzau
Investigation of the phenylethanolamine N-methyltransferase gene as a candidate gene for hypertension.
Hypertension 1995;26(4):595-601.
1995: N J Schork; José E Krieger; M R Trolliet; K G Franchini; G Koike; E M Krieger; Eric S Lander; V J Dzau; Howard J Jacob
A biometrical genome search in rats reveals the multigenic basis of blood pressure variation.
Genome research 1995;5(2):164-72.
1995: A Pettersson; E S Winer; S Weksler-Zangen; Ake Lernmark; Howard J Jacob
Predictability of heterozygosity scores and polymorphism information content values for rat genetic markers.
Mammalian genome : official journal of the International Mammalian Genome Society 1995;6(8):512-20.
1995: Kenneth D Bloch; J R Wolfram; D M Brown; J D Roberts; D G Zapol; J J Lepore; Galina Filippov; J E Thomas; Howard J Jacob; Donald B Bloch
Three members of the nitric oxide synthase II gene family (NOS2A, NOS2B, and NOS2C) colocalize to human chromosome 17.
Genomics 1995;27(3):526-30.
1995: Howard J Jacob; D M Brown; R K Bunker; M J Daly; V J Dzau; A Goodman; G Koike; V Kren; T Kurtz; A Lernmark
A genetic linkage map of the laboratory rat, Rattus norvegicus.
Nature genetics 1995;9(1):63-9.
1994: G Koike; M Horiuchi; T Yamada; Claude Szpirer; Howard J Jacob; Victor J Dzau
Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung.
Biochemical and biophysical research communications 1994;203(3):1842-50.
1994: G Koike; José E Krieger; Howard J Jacob; M Mukoyama; RE Pratt; Victor J Dzau
Angiotensin converting enzyme and genetic hypertension: cloning of rat cDNAs and characterization of the enzyme.
Biochemical and biophysical research communications 1994;198(1):380-6.
1993: H Rakugi; Howard J Jacob; José E Krieger; Julie R Ingelfinger; RE Pratt
Vascular injury induces angiotensinogen gene expression in the media and neointima.
Circulation 1993;87(1):283-90.
1991: Howard J Jacob; Curt D Sigmund; T R Shockley; K W Gross; Victor J Dzau
Renin promoter SV40 T-antigen transgenic mouse. A model of primary renal vascular hyperplasia.
Hypertension 1991;17(6 Pt 2):1167-62.