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Uwe Jacob

Research Profile

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Genes & Molecular Sequences

Amino Acid Sequences

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TOP 3
A K Pröbstel; Kevin Rostasy; P Sperl; W Stark; E Tantsis; A Villalobos; F Weber; Robert Weissert; H Wekerle; B Banwell; A Bar-Or; R Bittner; A Blaschek; Constanze Breithaupt; Fabienne Brilot; R C Dale; Klaus Dornmair; Ignasi Forné; J Gärtner; Reinhard Hohlfeld; Uwe Jacob; Dieter E Jenne; Mohsen Khademi; Markus Krumbholz; T Kuempfel; S Magalhaes; Edgar Meinl; Tomas Olsson; D Pohl; Tobias Derfuss
Antibodies to MOG are transient in childhood acute disseminated encephalomyelitis.
Constanze Breithaupt; Beatrix Schäfer; Hannah Pellkofer; Robert Huber; Christopher Linington; Uwe Jacob
Demyelinating myelin oligodendrocyte glycoprotein-specific autoantibody response is focused on one dominant conformational epitope region in rodents.
Sonja Werwitzke; D Trick; Peter Sondermann; Kenji Kamino; Brigitte Schlegelberger; K Kniesch; Andreas Tiede; Uwe Jacob; Reinhold E Schmidt; Torsten Witte
Treatment of lupus-prone NZB/NZW F1 mice with recombinant soluble Fc gamma receptor II (CD32).

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All Publications

2011: A K Pröbstel; Kevin Rostasy; P Sperl; W Stark; E Tantsis; A Villalobos; F Weber; Robert Weissert; H Wekerle; B Banwell; A Bar-Or; R Bittner; A Blaschek; Constanze Breithaupt; Fabienne Brilot; R C Dale; Klaus Dornmair; Ignasi Forné; J Gärtner; Reinhard Hohlfeld; Uwe Jacob; Dieter E Jenne; Mohsen Khademi; Markus Krumbholz; T Kuempfel; S Magalhaes; Edgar Meinl; Tomas Olsson; D Pohl; Tobias Derfuss
Antibodies to MOG are transient in childhood acute disseminated encephalomyelitis.
Neurology 2011;77(6):580-8.
2008: Constanze Breithaupt; Beatrix Schäfer; Hannah Pellkofer; Robert Huber; Christopher Linington; Uwe Jacob
Demyelinating myelin oligodendrocyte glycoprotein-specific autoantibody response is focused on one dominant conformational epitope region in rodents.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(2):1255-63.
2008: Sonja Werwitzke; D Trick; Peter Sondermann; Kenji Kamino; Brigitte Schlegelberger; K Kniesch; Andreas Tiede; Uwe Jacob; Reinhold E Schmidt; Torsten Witte
Treatment of lupus-prone NZB/NZW F1 mice with recombinant soluble Fc gamma receptor II (CD32).
Annals of the rheumatic diseases 2008;67(2):154-61.
2007: Thomas Steiner; Anne-Christin Lamerz; Petra Hess; Constanze Breithaupt; Stephan Krapp; Gleb P Bourenkov; Robert Huber; Rita Gerardy-Schahn; Uwe Jacob
Open and closed structures of the UDP-glucose pyrophosphorylase from Leishmania major.
The Journal of biological chemistry 2007;282(17):13003-10.
2007: Otto J P Kyrieleis; Robert Huber; Edgar Ong; Ryan Oehler; Mike Hunter; Edwin L Madison; Uwe Jacob
Crystal structure of the catalytic domain of DESC1, a new member of the type II transmembrane serine proteinase family.
The FEBS journal 2007;274(8):2148-60.
2006: Ewa Zesławska; Uwe Jacob; Jörg Stürzebecher; Barbara J Oleksyn
The crystal structures of 3-TAPAP in complexes with the urokinase-type plasminogen activator and picrate.
Bioorganic & medicinal chemistry letters 2006;16(1):228-34.
2004: Anja K Münster-Kühnel; Joe Tiralongo; Stephan Krapp; Birgit Weinhold; Valentina Ritz-Sedlacek; Uwe Jacob; Rita Gerardy-Schahn
Structure and function of vertebrate CMP-sialic acid synthetases.
Glycobiology 2004;14(10):43R-51R.
2004: Andrea Schweinitz; Torsten Steinmetzer; Ingo J Banke; Matthias J E Arlt; Anne Stürzebecher; Oliver Schuster; Andreas Geissler; Helmut Giersiefen; Ewa Zeslawska; Uwe Jacob; Achim Krüger; Jörg Stürzebecher
Design of novel and selective inhibitors of urokinase-type plasminogen activator with improved pharmacokinetic properties for use as antimetastatic agents.
The Journal of biological chemistry 2004;279(32):33613-22.
2003: Stephan Krapp; Anja K Münster-Kühnel; Jens Thomas Kaiser; Robert Huber; Joe Tiralongo; Rita Gerardy-Schahn; Uwe Jacob
The crystal structure of murine CMP-5-N-acetylneuraminic acid synthetase.
Journal of molecular biology 2003;334(4):625-37.
2003: Constanze Breithaupt; Anna Schubart; Hilke Zander; Arne Skerra; Robert Huber; Christopher Linington; Uwe Jacob
Structural insights into the antigenicity of myelin oligodendrocyte glycoprotein.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(16):9446-51.
2003: Kerstin Wendt; Iris Schall; Robert Huber; Wolfgang Buckel; Uwe Jacob
Crystal structure of the carboxyltransferase subunit of the bacterial sodium ion pump glutaconyl-coenzyme A decarboxylase.
The EMBO journal 2003;22(14):3493-502.
2003: Ewa Zeslawska; Uwe Jacob; Andrea Schweinitz; Gary Coombs; Wolfram Bode; Edwin Madison
Crystals of urokinase type plasminogen activator complexes reveal the binding mode of peptidomimetic inhibitors.
Journal of molecular biology 2003;328(1):109-18.
2001: Kerstin Wendt; Hartmut C Vodermaier; Uwe Jacob; Christian Gieffers; Michael Gmachl; Jan-Michael Peters; Robert Huber; Peter Sondermann
Crystal structure of the APC10/DOC1 subunit of the human anaphase-promoting complex.
Nature structural biology 2001;8(9):784-8.
2001: Peter Sondermann; Johannes Kaiser; Uwe Jacob
Molecular basis for immune complex recognition: a comparison of Fc-receptor structures.
Journal of molecular biology 2001;309(3):737-49.
2000: Ewa Zeslawska; Andrea Schweinitz; Annette Karcher; Peter Sondermann; Stefan Sperl; Jörg Stürzebecher; Uwe Jacob
Crystals of the urokinase type plasminogen activator variant beta(c)-uPAin complex with small molecule inhibitors open the way towards structure-based drug design.
Journal of molecular biology 2000;301(2):465-75.
2000: Peter Sondermann; Robert Huber; Vaughan Oosthuizen; Uwe Jacob
The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complex.
Nature 2000;406(6793):267-73.
2000: Stefan Sperl; Uwe Jacob; Nuria Arroyo De Prada; Jörg Stürzebecher; Olaf G Wilhelm; Wolfram Bode; Viktor Magdolen; Robert Huber; Luis Moroder
(4-aminomethyl)phenylguanidine derivatives as nonpeptidic highly selective inhibitors of human urokinase.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5113-8.
2000: T Dams; Guenter Auerbach; Gerd Bader; Uwe Jacob; Ploom Tarmo; Robert Huber; Rainer Jaenicke
The crystal structure of dihydrofolate reductase from Thermotoga maritima: molecular features of thermostability.
Journal of molecular biology 2000;297(3):659-72.
1999: A Eichinger; Hans-Georg Beisel; Uwe Jacob; Robert Huber; FJ Medrano; Agnieszka Banbula; Jan Potempa; James Travis; Wolfram Bode
Crystal structure of gingipain R: an Arg-specific bacterial cysteine proteinase with a caspase-like fold.
The EMBO journal 1999;18(20):5453-62.
1999: Peter Sondermann; Uwe Jacob; C Kutscher; J Frey
Characterization and crystallization of soluble human Fc gamma receptor II (CD32) isoforms produced in insect cells.
Biochemistry 1999;38(26):8469-77.
1999: Peter Sondermann; Uwe Jacob
Human Fcgamma receptor IIb expressed in Escherichia coli reveals IgG binding capability.
Biological chemistry 1999;380(6):717-21.
1999: Clemens Steegborn; Tim Clausen; Peter Sondermann; Uwe Jacob; Michael Worbs; S Marinkovic; Robert Huber; Markus C Wahl
Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration.
The Journal of biological chemistry 1999;274(18):12675-84.
1999: Peter Sondermann; Robert Huber; Uwe Jacob
Crystal structure of the soluble form of the human fcgamma-receptor IIb: a new member of the immunoglobulin superfamily at 1.7 A resolution.
The EMBO journal 1999;18(5):1095-103.
1998: MA Parry; Uwe Jacob; Robert Huber; Anne Wisner; Cassian Bon; Wolfram Bode
The crystal structure of the novel snake venom plasminogen activator TSV-PA: a prototype structure for snake venom serine proteinases.
Structure (London, England : 1993) 1998;6(9):1195-206.
1998: Viktor Magdolen; Sybille Albrecht; Matthias Kotzsch; C Haller; Markus Bürgle; Uwe Jacob; Marianne Grosser; Horst Kessler; Henner Graeff; M Müller; Manfred Schmitt; Thomas Luther
Immunological and functional analyses of the extracellular domain of human tissue factor.
Biological chemistry 1998;379(2):157-65.
1997: Guenter Auerbach; A Herrmann; M Gütlich; Markus Fischer; Uwe Jacob; Adelbert Bacher; Robert Huber
The 1.25 A crystal structure of sepiapterin reductase reveals its binding mode to pterins and brain neurotransmitters.
The EMBO journal 1997;16(24):7219-30.
1997: Guenter Auerbach; Robert Huber; M Grättinger; K Zaiss; H Schurig; Rainer Jaenicke; Uwe Jacob
Closed structure of phosphoglycerate kinase from Thermotoga maritima reveals the catalytic mechanism and determinants of thermal stability.
Structure (London, England : 1993) 1997;5(11):1475-83.
1997: S Liemann; I Bringemeier; J Benz; P Göttig; A Hofmann; Robert Huber; Angelika A Noegel; Uwe Jacob
Crystal structure of the C-terminal tetrad repeat from synexin (annexin VII) of Dictyostelium discoideum.
Journal of molecular biology 1997;270(1):79-88.
1997: Uwe Jacob; M Mack; Tim Clausen; Robert Huber; Wolfgang Buckel; Albrecht Messerschmidt
Glutaconate CoA-transferase from Acidaminococcus fermentans: the crystal structure reveals homology with other CoA-transferases.
Structure (London, England : 1993) 1997;5(3):415-26.
1997: Guenter Auerbach; Uwe Jacob; M Grättinger; H Schurig; Rainer Jaenicke
Crystallographic analysis of phosphoglycerate kinase from the hyperthermophilic bacterium Thermotoga maritima.
Biological chemistry 1997;378(3-4):327-9.