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Elizabeth Jacobs

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Chemicals & Drugs

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Pulmonary Circulation

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Feng Gao; Elizabeth R Jacobs; Cortney Joneikis; Robert Molthen; John E Moulder; Jayashree Narayanan; R Nagarjun Rao; Aniko Szabo; Brian L Fish; Meetha Medhora
Enalapril mitigates focal alveolar lesions, a histological marker of late pulmonary injury by radiation to the lung.
John C Densmore; Anne V Clough; Breana Cummens; Paul M Jeziorczak; Meetha Medhora; Kirkwood A Pritchard; Arjun Rao; Elizabeth R Jacobs
Rattus model utilizing selective pulmonary ischemia induces bronchiolitis obliterans organizing pneumonia.
Feng Gao; Elizabeth R Jacobs; Lakhan Kma; Susan R Doctrow; Brian L Fish; Robert Molthen; John E Moulder; Aniko Szabo; Meetha Medhora
Short-term treatment with a SOD/catalase mimetic, EUK-207, mitigates pneumonitis and fibrosis after single-dose total-body or whole-thoracic irradiation.

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2013: Feng Gao; Elizabeth R Jacobs; Cortney Joneikis; Robert Molthen; John E Moulder; Jayashree Narayanan; R Nagarjun Rao; Aniko Szabo; Brian L Fish; Meetha Medhora
Enalapril mitigates focal alveolar lesions, a histological marker of late pulmonary injury by radiation to the lung.
Radiation research 2013;179(4):465-74.
2013: John C Densmore; Anne V Clough; Breana Cummens; Paul M Jeziorczak; Meetha Medhora; Kirkwood A Pritchard; Arjun Rao; Elizabeth R Jacobs
Rattus model utilizing selective pulmonary ischemia induces bronchiolitis obliterans organizing pneumonia.
Shock (Augusta, Ga.) 2013;39(3):271-7.
2012: Feng Gao; Elizabeth R Jacobs; Lakhan Kma; Susan R Doctrow; Brian L Fish; Robert Molthen; John E Moulder; Aniko Szabo; Meetha Medhora
Short-term treatment with a SOD/catalase mimetic, EUK-207, mitigates pneumonitis and fibrosis after single-dose total-body or whole-thoracic irradiation.
Radiation research 2012;178(5):468-80.
2012: Robert C Molthen; John E Moulder; Qingping Wu; Brian L Fish; Elizabeth R Jacobs; Meetha Medhora
Mitigation of radiation induced pulmonary vascular injury by delayed treatment with captopril.
Respirology (Carlton, Vic.) 2012;17(8):1261-8.
2012: Elizabeth R Jacobs; Meetha Medhora; Irshad Ali; Sreedhar Bodiga; Aaron M Falck; John R Falck; Anuradha Dhanasekaran
Tissue protection and endothelial cell signaling by 20-HETE analogs in intact ex vivo lung slices.
Experimental cell research 2012;318(16):2143-52.
2012: Rahul Nanchal; Jayshil Patel; Amit Taneja; Sergey Tarima; Jeff Whittle; Abhishek Deshmukh; Elizabeth R Jacobs; Gagan Kumar
Pulmonary embolism: the weekend effect.
Chest 2012;142(3):690-6.
2012: D R Harland; Elizabeth R Jacobs; L D Lorenz; Bruce E Dunn; K Fay; Stephanie K Gruenloh; Jayashree Narayanan; Meetha Medhora
Acute effects of prostaglandin E1 and E2 on vascular reactivity and blood flow in situ in the chick chorioallantoic membrane.
Prostaglandins, leukotrienes, and essential fatty acids 2012;87(2-3):79-89.
2012: Meetha Medhora; John E Moulder; Brian L Fish; Feng Gao; Elizabeth R Jacobs; Aniko Szabo
Dose-modifying factor for captopril for mitigation of radiation injury to normal lung.
Journal of radiation research 2012;53(4):633-40.
2012: Lakhan Kma; Brian L Fish; Feng Gao; Elizabeth R Jacobs; John E Moulder; Meetha Medhora
Angiotensin converting enzyme inhibitors mitigate collagen synthesis induced by a single dose of radiation to the whole thorax.
Journal of radiation research 2012;53(1):10-7.
2011: Lewis Somberg; Ram Nirula; Michael Bousamra; Jill Friesema; Daling Zhu; Meetha Medhora; Elizabeth R Jacobs
Effects of a localized high-flow anastomosis between the aorta and left lower lobe pulmonary artery on great vessel flow and pulmonary arterial reactivity in the contralateral lung.
The Journal of thoracic and cardiovascular surgery 2011;141(2):407-12.
2011: Sandra Pfister; Lewis Somberg; Timothy F Lowry; Ying Gao; Meetha Medhora; Elizabeth R Jacobs
Mechanisms underlying increased reactivity of pulmonary arteries contralateral to a localized high-flow anastomosis.
The Journal of thoracic and cardiovascular surgery 2011;141(2):425-31.
2010: Sreedhar Bodiga; Stephanie K Gruenloh; Ying Gao; Vijay L Manthati; Narsimhaswamy Dubasi; John R Falck; Meetha Medhora; Elizabeth R Jacobs
20-HETE-induced nitric oxide production in pulmonary artery endothelial cells is mediated by NADPH oxidase, H2O2, and PI3-kinase/Akt.
American journal of physiology. Lung cellular and molecular physiology 2010;298(4):L564-74.
2009: Swarajit N Ghosh; Rong Zhang; Brian L Fish; Vladimir A Semenenko; X Allen Li; John E Moulder; Elizabeth R Jacobs; Meetha Medhora
Renin-Angiotensin system suppression mitigates experimental radiation pneumonitis.
International journal of radiation oncology, biology, physics 2009;75(5):1528-36.
2009: Sreedhar Bodiga; Rong Zhang; Dexter E Jacobs; Brandon T Larsen; Akihito Tampo; Vijay L Manthati; Wai-Meng Kwok; Darryl C Zeldin; John R Falck; David D Gutterman; Elizabeth R Jacobs; Meetha Medhora
Protective actions of epoxyeicosatrienoic acid: dual targeting of cardiovascular PI3K and KATP channels.
Journal of molecular and cellular cardiology 2009;46(6):978-88.
2009: Anuradha Dhanasekaran; Sreedhar Bodiga; Stephanie K Gruenloh; Ying Gao; Laurel Dunn; John R Falck; J Noelle Buonaccorsi; Meetha Medhora; Elizabeth R Jacobs
20-HETE increases survival and decreases apoptosis in pulmonary arteries and pulmonary artery endothelial cells.
American journal of physiology. Heart and circulatory physiology 2009;296(3):H777-86.
2009: Shibin Jacob; Ahmed Khan; Elizabeth R Jacobs; Prem Kandiah; Rahul Nanchal
Prolonged hypothermia as a bridge to recovery for cerebral edema and intracranial hypertension associated with fulminant hepatic failure.
Neurocritical care 2009;11(2):242-6.
2008: Meetha Medhora; Yuenmu Chen; Stephanie K Gruenloh; Daniel Harland; Sreedhar Bodiga; Jacek Zielonka; Debebe Gebremedhin; Ying Gao; John R Falck; Siddam Anjaiah; Elizabeth R Jacobs
20-HETE increases superoxide production and activates NAPDH oxidase in pulmonary artery endothelial cells.
American journal of physiology. Lung cellular and molecular physiology 2008;294(5):L902-11.
2008: Meetha Medhora; Anuradha Dhanasekaran; Phillip F Pratt; Craig R Cook; Laurel K Dunn; Stephanie K Gruenloh; Elizabeth R Jacobs
Role of JNK in network formation of human lung microvascular endothelial cells.
American journal of physiology. Lung cellular and molecular physiology 2008;294(4):L676-85.
2008: Anuradha Dhanasekaran; Stephanie K Gruenloh; J Noelle Buonaccorsi; Rong Zhang; Garrett J Gross; John R Falck; Paresh K Patel; Elizabeth R Jacobs; Meetha Medhora
Multiple antiapoptotic targets of the PI3K/Akt survival pathway are activated by epoxyeicosatrienoic acids to protect cardiomyocytes from hypoxia/anoxia.
American journal of physiology. Heart and circulatory physiology 2008;294(2):H724-35.
2007: Meetha Medhora; Anuradha Dhanasekaran; Stephanie K Gruenloh; Laurel K Dunn; Michael Gabrilovich; John R Falck; David R Harder; Elizabeth R Jacobs; Phillip F Pratt
Emerging mechanisms for growth and protection of the vasculature by cytochrome P450-derived products of arachidonic acid and other eicosanoids.
Prostaglandins & other lipid mediators 2007;82(1-4):19-29.
2006: Ken Yamaura; Debebe Gebremedhin; Chenyang Zhang; Jayashree Narayanan; K Hoefert; Elizabeth R Jacobs; Raymond C Koehler; David R Harder
Contribution of epoxyeicosatrienoic acids to the hypoxia-induced activation of Ca2+ -activated K+ channel current in cultured rat hippocampal astrocytes.
Neuroscience 2006;143(3):703-16.
2006: Elizabeth R Jacobs; Daling Zhu; Stephanie K Gruenloh; Bernardo Lopez; Meetha Medhora
VEGF-induced relaxation of pulmonary arteries is mediated by endothelial cytochrome P-450 hydroxylase.
American journal of physiology. Lung cellular and molecular physiology 2006;291(3):L369-77.
2006: Yuenmu Chen; Meetha Medhora; John R Falck; Kirkwood A Pritchard; Elizabeth R Jacobs
Mechanisms of activation of eNOS by 20-HETE and VEGF in bovine pulmonary artery endothelial cells.
American journal of physiology. Lung cellular and molecular physiology 2006;291(3):L378-85.
2006: Anuradha Dhanasekaran; Rula Al-Saghir; Bernardo Lopez; Daling Zhu; David D Gutterman; Elizabeth R Jacobs; Meetha Medhora
Protective effects of epoxyeicosatrienoic acids on human endothelial cells from the pulmonary and coronary vasculature.
American journal of physiology. Heart and circulatory physiology 2006;291(2):H517-31.
2005: Laurel K Dunn; Stephanie K Gruenloh; Bruce E Dunn; D Sudarshan Reddy; John R Falck; Elizabeth R Jacobs; Meetha Medhora
Chick chorioallantoic membrane as an in vivo model to study vasoreactivity: characterization of development-dependent hyperemia induced by epoxyeicosatrienoic acids (EETs).
The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology 2005;285(2):771-80.
2004: Girija G Konduri; Ivane Bakhutashvili; Recia Frenn; Indira Chandrasekhar; Elizabeth R Jacobs; Ashwani K Khanna
P2Y purine receptor responses and expression in the pulmonary circulation of juvenile rabbits.
American journal of physiology. Heart and circulatory physiology 2004;287(1):H157-64.
2003: Daling Zhu; Meetha Medhora; William B Campbell; Nancy Spitzbarth; John E Baker; Elizabeth R Jacobs
Chronic hypoxia activates lung 15-lipoxygenase, which catalyzes production of 15-HETE and enhances constriction in neonatal rabbit pulmonary arteries.
Circulation research 2003;92(9):992-1000.
2003: Meetha Medhora; John Daniels; Kavita Mundey; Beate Fisslthaler; Rudi Busse; Elizabeth R Jacobs; David R Harder
Epoxygenase-driven angiogenesis in human lung microvascular endothelial cells.
American journal of physiology. Heart and circulatory physiology 2003;284(1):H215-24.
2002: Ming Yu; Ryan P McAndrew; Rula Al-Saghir; Kristopher G Maier; Meetha Medhora; Richard J Roman; Elizabeth R Jacobs
Nitric oxide contributes to 20-HETE-induced relaxation of pulmonary arteries.
Journal of applied physiology (Bethesda, Md. : 1985) 2002;93(4):1391-9.
2002: A Serra; Daniel T Brozoski; T Simeon; J Yi; J Bastasic; Ralph A Franciosi; Elizabeth R Jacobs; Hubert V Forster
Serotonin and serotonin receptor expression in the aorta of carotid intact and denervated newborns.
Respiratory physiology & neurobiology 2002;132(3):253-64.
2002: Daling Zhu; Chenyang Zhang; Meetha Medhora; Elizabeth R Jacobs
CYP4A mRNA, protein, and product in rat lungs: novel localization in vascular endothelium.
Journal of applied physiology (Bethesda, Md. : 1985) 2002;93(1):330-7.
2002: Meetha Medhora; Michael Bousamra; Daling Zhu; Lewis B Somberg; Elizabeth R Jacobs
Upregulation of collagens detected by gene array in a model of flow-induced pulmonary vascular remodeling.
American journal of physiology. Heart and circulatory physiology 2002;282(2):H414-22.
2001: Elizabeth R Jacobs; Darryl C Zeldin
The lung HETEs (and EETs) up.
American journal of physiology. Heart and circulatory physiology 2001;280(1):H1-H10.
2000: Daling Zhu; EK Birks; C A Dawson; M Patel; John R Falck; Kenneth W Presberg; Richard J Roman; Elizabeth R Jacobs
Hypoxic pulmonary vasoconstriction is modified by P-450 metabolites.
American journal of physiology. Heart and circulatory physiology 2000;279(4):H1526-33.
2000: Richard M Effros; Elizabeth R Jacobs; Ralph M Schapira; Julie Biller
Response of the lungs to aspiration.
The American journal of medicine 2000;108 Suppl 4a():15S-19S.
2000: Daling Zhu; Michael Bousamra; Darryl C Zeldin; John R Falck; Mary I Townsley; David R Harder; Richard J Roman; Elizabeth R Jacobs
Epoxyeicosatrienoic acids constrict isolated pressurized rabbit pulmonary arteries.
American journal of physiology. Lung cellular and molecular physiology 2000;278(2):L335-43.
1999: Richard M Effros; Elizabeth R Jacobs; Ralph M Schapira; Wen Lin; Kenneth W Presberg
Increasing airway pressures can promote transvascular edema reabsorption.
Chest 1999;116(1 Suppl):30S-31S.
1999: Maryam Parviz; Michael Bousamra; JH Chammas; EK Birks; Kenneth W Presberg; Elizabeth R Jacobs; Leif D Nelin
Effects of chronic pulmonary overcirculation on pulmonary vasomotor tone.
The Annals of thoracic surgery 1999;67(2):522-7.
1999: Elizabeth R Jacobs; Richard M Effros; John R Falck; Komandla Malla Reddy; William B Campbell; Daling Zhu
Airway synthesis of 20-hydroxyeicosatetraenoic acid: metabolism by cyclooxygenase to a bronchodilator.
The American journal of physiology 1999;276(2 Pt 1):L280-8.
1998: Richard M Effros; Ralph M Schapira; Kenneth W Presberg; Kutlan Ozker; Elizabeth R Jacobs
Stop-flow studies of solute uptake in rat lungs.
Journal of applied physiology (Bethesda, Md. : 1985) 1998;85(3):986-92.
1998: Daling Zhu; Richard M Effros; David R Harder; Richard J Roman; Elizabeth R Jacobs
Tissue sources of cytochrome P450 4A and 20-HETE synthesis in rabbit lungs.
American journal of respiratory cell and molecular biology 1998;19(1):121-8.
1998: Debebe Gebremedhin; AR Lange; Jayashree Narayanan; M R Aebly; Elizabeth R Jacobs; David R Harder
Cat cerebral arterial smooth muscle cells express cytochrome P450 4A2 enzyme and produce the vasoconstrictor 20-HETE which enhances L-type Ca2+ current.
The Journal of physiology 1998;507 ( Pt 3)():771-81.
1997: Richard M Effros; C Darin; Elizabeth R Jacobs; Rick A Rogers; Gary S Krenz; Eveline E Schneeberger
Water transport and the distribution of aquaporin-1 in pulmonary air spaces.
Journal of applied physiology (Bethesda, Md. : 1985) 1997;83(3):1002-16.
1997: EK Birks; Michael Bousamra; Kenneth W Presberg; J A Marsh; Richard M Effros; Elizabeth R Jacobs
Human pulmonary arteries dilate to 20-HETE, an endogenous eicosanoid of lung tissue.
The American journal of physiology 1997;272(5 Pt 1):L823-9.
1996: Ai-Ping Zou; J T Fleming; John R Falck; Elizabeth R Jacobs; Debebe Gebremedhin; David R Harder; Richard J Roman
Stereospecific effects of epoxyeicosatrienoic acids on renal vascular tone and K(+)-channel activity.
The American journal of physiology 1996;270(5 Pt 2):F822-32.
1996: Debebe Gebremedhin; M Kaldunski; Elizabeth R Jacobs; David R Harder; Richard J Roman
Coexistence of two types of Ca(2+)-activated K+ channels in rat renal arterioles.
The American journal of physiology 1996;270(1 Pt 2):F69-81.
1996: Ai-Ping Zou; J T Fleming; John R Falck; Elizabeth R Jacobs; Debebe Gebremedhin; David R Harder; Richard J Roman
20-HETE is an endogenous inhibitor of the large-conductance Ca(2+)-activated K+ channel in renal arterioles.
The American journal of physiology 1996;270(1 Pt 2):R228-37.
1995: Elizabeth R Jacobs; C Cheliakine; Debebe Gebremedhin; EK Birks; P F Davies; David R Harder
Shear activated channels in cell-attached patches of cultured bovine aortic endothelial cells.
Pflügers Archiv : European journal of physiology 1995;431(1):129-31.
1993: G D Gerboth; Richard M Effros; Richard J Roman; Elizabeth R Jacobs
pH-induced calcium transients in type II alveolar epithelial cells.
The American journal of physiology 1993;264(5 Pt 1):L448-57.