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Heinz Jacobs

Research Profile

Living Beings

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Genes, Immunoglobulin

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Carmen Gerlach; Heinz Jacobs; Shalin H Naik; Leïla Perié; Jan C Rohr; Jos Urbanus; Jeroen van Heijst; Nienke van Rooij; Arno Velds; Joost B Beltman; Rob J De Boer; Schumacher Ton
Heterogeneous differentiation patterns of individual CD8+ T cells.
Jonathan M Coquet; Heinz Jacobs; Jop Kind; Sabine Middendorp; Gerda van der Horst; Elise A M Veraar; Yanling Xiao; Jannie Borst
The CD27 and CD70 costimulatory pathway inhibits effector function of T helper 17 cells and attenuates associated autoimmunity.
Piya Temviriyanukul; Sandrine van Hees-Stuivenberg; Niels De Wind; Frédéric Delbos; Heinz Jacobs; Jacob G Jansen
Temporally distinct translesion synthesis pathways for ultraviolet light-induced photoproducts in the mammalian genome.

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All Publications

2013: Carmen Gerlach; Heinz Jacobs; Shalin H Naik; Leïla Perié; Jan C Rohr; Jos Urbanus; Jeroen van Heijst; Nienke van Rooij; Arno Velds; Joost B Beltman; Rob J De Boer; Schumacher Ton
Heterogeneous differentiation patterns of individual CD8+ T cells.
Science (New York, N.Y.) 2013;340(6132):635-9.
2013: Jonathan M Coquet; Heinz Jacobs; Jop Kind; Sabine Middendorp; Gerda van der Horst; Elise A M Veraar; Yanling Xiao; Jannie Borst
The CD27 and CD70 costimulatory pathway inhibits effector function of T helper 17 cells and attenuates associated autoimmunity.
Immunity 2013;38(1):53-65.
2012: Piya Temviriyanukul; Sandrine van Hees-Stuivenberg; Niels De Wind; Frédéric Delbos; Heinz Jacobs; Jacob G Jansen
Temporally distinct translesion synthesis pathways for ultraviolet light-induced photoproducts in the mammalian genome.
DNA repair 2012;11(6):550-8.
2011: Peter Krijger; Petra Langerak; Claude-Agnès Reynaud; Paul van den Berk; Niek Wit; Niels De Wind; Jacob G Jansen; Heinz Jacobs
PCNA ubiquitination-independent activation of polymerase η during somatic hypermutation and DNA damage tolerance.
DNA repair 2011;10(10):1051-9.
2011: Ayal Hendel; Heinz Jacobs; Jungmin Kim; Peter H L Krijger; Petra Langerak; Kyoo-young Lee; Thomas Carell; Alan D'Andrea; Noam Diamant; Nicholas E Geacintov; Zohar Goren; Kyungjae Myung; Thomas Reissner; Satoshi Tateishi; Zvi Livneh
PCNA ubiquitination is important, but not essential for translesion DNA synthesis in mammalian cells.
PLoS genetics 2011;7(9):e1002262.
2011: Johannes Lutz; Werner Muller; Chander Raman; Edith Roth; Paul van den Berk; Matthias Wabl; Marinus R Heideman; Heinz Jacobs; Hans-Martin Jäck
Pro-B cells sense productive immunoglobulin heavy chain rearrangement irrespective of polypeptide production.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(26):10644-9.
2011: Peter Krijger; Kyoo-Young Lee; Niek Wit; Paul van den Berk; Xiaoli Wu; Henk P Roest; Alex Maas; Hao Ding; Jan H J Hoeijmakers; Kyungjae Myung; Heinz Jacobs
HLTF and SHPRH are not essential for PCNA polyubiquitination, survival and somatic hypermutation: existence of an alternative E3 ligase.
DNA repair 2011;10(4):438-44.
2011: Niek Wit; Peter Krijger; Paul van den Berk; Heinz Jacobs
Lysine residue 185 of Rad1 is a topological but not a functional counterpart of lysine residue 164 of PCNA.
PloS one 2011;6(1):e16669.
2010: Peter Krijger; Niek Wit; Paul van den Berk; Heinz Jacobs
The Fanconi anemia core complex is dispensable during somatic hypermutation and class switch recombination.
PloS one 2010;5(12):e15236.
2009: Peter Krijger; Petra Langerak; Paul van den Berk; Heinz Jacobs
Dependence of nucleotide substitutions on Ung2, Msh2, and PCNA-Ub during somatic hypermutation.
The Journal of experimental medicine 2009;206(12):2603-11.
2009: Sabine Middendorp; Yanling Xiao; Ji-Ying Song; Victor Peperzak; Peter Krijger; Heinz Jacobs; Jannie Borst
Mice deficient for CD137 ligand are predisposed to develop germinal center-derived B-cell lymphoma.
Blood 2009;114(11):2280-9.
2009: Petra Langerak; Peter Krijger; Marinus R Heideman; Paul van den Berk; Heinz Jacobs
Somatic hypermutation of immunoglobulin genes: lessons from proliferating cell nuclear antigenK164R mutant mice.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2009;364(1517):621-9.
2007: Petra Langerak; Anders O H Nygren; Peter Krijger; Paul van den Berk; Heinz Jacobs
A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification.
The Journal of experimental medicine 2007;204(8):1989-98.
2006: Silke Schnell; Corinne Démollière; Paul van den Berk; Heinz Jacobs
Gimap4 accelerates T-cell death.
Blood 2006;108(2):591-9.
2006: Silke Schnell; Corinne Démollière; Paul van den Berk; Joerg Kirberg; Heinz Jacobs
Constitutive expression of the pre-TCR enables development of mature T cells.
International immunology 2006;18(6):911-20.
2006: Jacob G Jansen; Petra Langerak; Anastasia Tsaalbi-Shtylik; Paul van den Berk; Heinz Jacobs; Niels De Wind
Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice.
The Journal of experimental medicine 2006;203(2):319-23.
2005: Petra Langerak; Anders O H Nygren; Jan P Schouten; Heinz Jacobs
Rapid and quantitative detection of homologous and non-homologous recombination events using three oligonucleotide MLPA.
Nucleic acids research 2005;33(22):e188.
2005: Jacob G Jansen; Anastasia Tsaalbi-Shtylik; Petra Langerak; Fabienne Calléja; Carel Meijers; Heinz Jacobs; Niels De Wind
The BRCT domain of mammalian Rev1 is involved in regulating DNA translesion synthesis.
Nucleic acids research 2005;33(1):356-65.
2004: Yanling Xiao; Jenny Hendriks; Petra Langerak; Heinz Jacobs; Jannie Borst
CD27 is acquired by primed B cells at the centroblast stage and promotes germinal center formation.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(12):7432-41.
2003: Linda Bross; Heinz Jacobs
DNA double strand breaks occur independent of AID in hypermutating Ig genes.
Clinical & developmental immunology 2003;10(2-4):83-9.
2003: Linda Bross; Joanna Wesoly; Jean-Marie Buerstedde; Roland Kanaar; Heinz Jacobs
Somatic hypermutation does not require Rad54 and Rad54B-mediated homologous recombination.
European journal of immunology 2003;33(2):352-7.
2002: Linda Bross; Masamichi Muramatsu; Kazuo Kinoshita; Tasuku Honjo; Heinz Jacobs
DNA double-strand breaks: prior to but not sufficient in targeting hypermutation.
The Journal of experimental medicine 2002;195(9):1187-92.
2001: Heinz Jacobs; Linda Bross
Towards an understanding of somatic hypermutation.
Current opinion in immunology 2001;13(2):208-18.
2001: Heinz Jacobs; Klaus Rajewsky; Y Fukita; Linda Bross
Indirect and direct evidence for DNA double-strand breaks in hypermutating immunoglobulin genes.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2001;356(1405):119-25.
2000: Linda Bross; Y Fukita; F McBlane; Corinne Démollière; Klaus Rajewsky; Heinz Jacobs
DNA double-strand breaks in immunoglobulin genes undergoing somatic hypermutation.
Immunity 2000;13(5):589-97.
2000: Heinz Jacobs
TCR-independent T cell development mediated by gain-of-oncogene function or loss-of-tumor-suppressor gene function.
Seminars in immunology 2000;12(5):487-502.
1999: Heinz Jacobs; Paul Krimpenfort; Mariëlle C Haks; J Allen; Bianca Blom; Corinne Démollière; Ada M Kruisbeek; Hergen Spits; Anton Berns
PIM1 reconstitutes thymus cellularity in interleukin 7- and common gamma chain-mutant mice and permits thymocyte maturation in Rag- but not CD3gamma-deficient mice.
The Journal of experimental medicine 1999;190(8):1059-68.
1999: Heinz Jacobs; andrea puglisi; Klaus Rajewsky; Y Fukita
Tuning somatic hypermutation by transcription.
Current topics in microbiology and immunology 1999;246():149-58; discussion 159.
1998: Y Fukita; Heinz Jacobs; Klaus Rajewsky
Somatic hypermutation in the heavy chain locus correlates with transcription.
Immunity 1998;9(1):105-14.
1998: Heinz Jacobs; Y Fukita; G T van der Horst; J de Boer; Geert Weeda; Jeroen Essers; Niels De Wind; Bevin P Engelward; Leona D Samson; S Verbeek; Josiane Ménissier de Murcia; G de Murcia; Hein te Riele; Klaus Rajewsky
Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice.
The Journal of experimental medicine 1998;187(11):1735-43.
1997: MJ Alkema; Heinz Jacobs; Maarten van Lohuizen; Anton Berns
Pertubation of B and T cell development and predisposition to lymphomagenesis in Emu Bmi1 transgenic mice require the Bmi1 RING finger.
Oncogene 1997;15(8):899-910.
1997: D Acton; Heinz Jacobs; J Domen; Anton Berns
Bcl-2 reduces lymphomagenesis in deltaV-TCRbeta transgenic mice.
Oncogene 1997;14(21):2497-501.
1997: M L Carrozza; Heinz Jacobs; D Acton; Inder M Verma; Anton Berns
Overexpression of the FosB2 gene in thymocytes causes aberrant development of T cells and thymic epithelial cells.
Oncogene 1997;14(9):1083-91.
1996: Heinz Jacobs; Ferry Ossendorp; Evert de Vries; K Ungewiss; Harald von Boehmer; Jannie Borst; Anton Berns
Oncogenic potential of a pre-T cell receptor lacking the TCR beta variable domain.
Oncogene 1996;12(10):2089-99.
1992: D Acton; J Domen; Heinz Jacobs; M Vlaar; S Korsmeyer; Anton Berns
Collaboration of pim-1 and bcl-2 in lymphomagenesis.
Current topics in microbiology and immunology 1992;182():293-8.