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Howard Jacobs

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Chemicals & Drugs

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Polymerase Chain Reaction

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TOP 3
Anne K Hyvärinen; Jaakko L O Pohjoismäki; Ian J Holt; Howard T Jacobs
Overexpression of MTERFD1 or MTERFD3 impairs the completion of mitochondrial DNA replication.
Alberto Sanz; Mikko Soikkeli; Manuel Portero-Otín; Angela Wilson; Esko Kemppainen; George McIlroy; Simo Ellilä; Kia K Kemppainen; Tea Tuomela; Matti Lakanmaa; Essi Kiviranta; Rhoda Stefanatos; Eric Dufour; Bettina Hutz; Alba Naudí; Mariona Jové; Akbar Zeb; Suvi Vartiainen; Akemi Matsuno-Yagi; Takao Yagi; Pierre Rustin; Reinald Pamplona; Howard T Jacobs
Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction.
Jaakko L O Pohjoismäki; J Bradley Holmes; Stuart R Wood; Ming-Yao Yang; Takehiro Yasukawa; Aurelio Reyes; Laura J Bailey; Tricia J Cluett; Steffi Goffart; Smaranda Willcox; Rachel E Rigby; Andrew P Jackson; Johannes N Spelbrink; Jack D Griffith; Robert J Crouch; Howard T Jacobs; Ian J Holt
Mammalian mitochondrial DNA replication intermediates are essentially duplex but contain extensive tracts of RNA/DNA hybrid.

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All Publications

2011: Anne K Hyvärinen; Jaakko L O Pohjoismäki; Ian J Holt; Howard T Jacobs
Overexpression of MTERFD1 or MTERFD3 impairs the completion of mitochondrial DNA replication.
Molecular biology reports 2011;38(2):1321-8.
2010: Alberto Sanz; Mikko Soikkeli; Manuel Portero-Otín; Angela Wilson; Esko Kemppainen; George McIlroy; Simo Ellilä; Kia K Kemppainen; Tea Tuomela; Matti Lakanmaa; Essi Kiviranta; Rhoda Stefanatos; Eric Dufour; Bettina Hutz; Alba Naudí; Mariona Jové; Akbar Zeb; Suvi Vartiainen; Akemi Matsuno-Yagi; Takao Yagi; Pierre Rustin; Reinald Pamplona; Howard T Jacobs
Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(20):9105-10.
2010: Jaakko L O Pohjoismäki; J Bradley Holmes; Stuart R Wood; Ming-Yao Yang; Takehiro Yasukawa; Aurelio Reyes; Laura J Bailey; Tricia J Cluett; Steffi Goffart; Smaranda Willcox; Rachel E Rigby; Andrew P Jackson; Johannes N Spelbrink; Jack D Griffith; Robert J Crouch; Howard T Jacobs; Ian J Holt
Mammalian mitochondrial DNA replication intermediates are essentially duplex but contain extensive tracts of RNA/DNA hybrid.
Journal of molecular biology 2010;397(5):1144-55.
2010: Alberto Sanz; Daniel J M Fernández-Ayala; Rhoda Ka Stefanatos; Howard T Jacobs
Mitochondrial ROS production correlates with, but does not directly regulate lifespan in Drosophila.
Aging 2010;2(4):200-23.
2010: Anne K Hyvärinen; Mona K Kumanto; Sanna K Marjavaara; Howard T Jacobs
Effects on mitochondrial transcription of manipulating mTERF protein levels in cultured human HEK293 cells.
BMC molecular biology 2010;11():72.
2010: Jaakko L O Pohjoismäki; Steffi Goffart; Robert W Taylor; Douglas M Turnbull; Anu Suomalainen; Howard T Jacobs; Pekka J Karhunen
Developmental and pathological changes in the human cardiac muscle mitochondrial DNA organization, replication and copy number.
PloS one 2010;5(5):e10426.
2010: Daniel J M Fernández-Ayala; Shanjun Chen; Esko Kemppainen; Kevin M C O'Dell; Howard T Jacobs
Gene expression in a Drosophila model of mitochondrial disease.
PloS one 2010;5(1):e8549.
2009: Esko Kemppainen; Daniel J M Fernández-Ayala; Laura C A Galbraith; Kevin M C O'Dell; Howard T Jacobs
Phenotypic suppression of the Drosophila mitochondrial disease-like mutant tko(25t) by duplication of the mutant gene in its natural chromosomal context.
Mitochondrion 2009;9(5):353-63.
2009: Jaakko L O Pohjoismäki; Steffi Goffart; Henna Tyynismaa; Smaranda Willcox; Tomomi Ide; Dongchon Kang; Anu Suomalainen; Pekka J Karhunen; Jack D Griffith; Ian J Holt; Howard T Jacobs
Human heart mitochondrial DNA is organized in complex catenated networks containing abundant four-way junctions and replication forks.
The Journal of biological chemistry 2009;284(32):21446-57.
2009: Ernesto Zanotto; Antti Häkkinen; Gabriel Teku; bairong shen; Andre S Ribeiro; Howard T Jacobs
NF-Y influences directionality of transcription from the bidirectional Mrps12/Sarsm promoter in both mouse and human cells.
Biochimica et biophysica acta 2009;1789(5):432-42.
2009: Daniel J M Fernandez-Ayala; Alberto Sanz; Suvi Vartiainen; Kia K Kemppainen; Marek Babusiak; Eero Mustalahti; Rodolfo Costa; Tea Tuomela; Massimo Zeviani; Jongkyeong Chung; Kevin M C O'Dell; Pierre Rustin; Howard T Jacobs
Expression of the Ciona intestinalis alternative oxidase (AOX) in Drosophila complements defects in mitochondrial oxidative phosphorylation.
Cell metabolism 2009;9(5):449-60.
2008: Ernesto Zanotto; Veikka Lehtonen; Howard T Jacobs
Modulation of Mrps12/Sarsm promoter activity in response to mitochondrial stress.
Biochimica et biophysica acta 2008;1783(12):2352-62.
2008: Helen A Lindsay; Richard A Baines; Richard ffrench-Constant; Kathryn S Lilley; Howard T Jacobs; Kevin M C O'Dell
The dominant cold-sensitive Out-cold mutants of Drosophila melanogaster have novel missense mutations in the voltage-gated sodium channel gene paralytic.
Genetics 2008;180(2):873-84.
2007: Martti Juhola; Jyri Saarikoski; Howard T Jacobs
On modeling of mutation probabilities.
Computers in biology and medicine 2007;37(12):1719-23.
2007: Janne Toivonen; Glenda A Walker; Pedro Martinez-Diaz; Ivana Bjedov; Yasmine Driege; Howard T Jacobs; David Gems; Linda Partridge
No influence of Indy on lifespan in Drosophila after correction for genetic and cytoplasmic background effects.
PLoS genetics 2007;3(6):e95.
2007: Anne K Hyvärinen; Jaakko L O Pohjoismäki; Aurelio Reyes; Sjoerd Wanrooij; Takehiro Yasukawa; Pekka J Karhunen; Johannes N Spelbrink; Ian J Holt; Howard T Jacobs
The mitochondrial transcription termination factor mTERF modulates replication pausing in human mitochondrial DNA.
Nucleic acids research 2007;35(19):6458-74.
2007: Ernesto Zanotto; Zahid Hussain Shah; Howard T Jacobs
The bidirectional promoter of two genes for the mitochondrial translational apparatus in mouse is regulated by an array of CCAAT boxes interacting with the transcription factor NF-Y.
Nucleic acids research 2007;35(2):664-77.
2006: Takehiro Yasukawa; Aurelio Reyes; Tricia J Cluett; Ming Yao Yang; Mark Bowmaker; Howard T Jacobs; Ian J Holt
Replication of vertebrate mitochondrial DNA entails transient ribonucleotide incorporation throughout the lagging strand.
The EMBO journal 2006;25(22):5358-71.
2006: Yohei Kirino; Takehiro Yasukawa; Sanna K Marjavaara; Howard T Jacobs; Ian J Holt; Kimitsuna Watanabe; Tsutomu Suzuki
Acquisition of the wobble modification in mitochondrial tRNALeu(CUN) bearing the G12300A mutation suppresses the MELAS molecular defect.
Human molecular genetics 2006;15(6):897-904.
2006: Gerrit A J Hakkaart; Emmanuel P Dassa; Howard T Jacobs; Pierre Rustin
Allotopic expression of a mitochondrial alternative oxidase confers cyanide resistance to human cell respiration.
EMBO reports 2006;7(3):341-5.
2006: Jaakko L O Pohjoismäki; Sjoerd Wanrooij; Anne K Hyvärinen; Steffi Goffart; Ian J Holt; Johannes N Spelbrink; Howard T Jacobs
Alterations to the expression level of mitochondrial transcription factor A, TFAM, modify the mode of mitochondrial DNA replication in cultured human cells.
Nucleic acids research 2006;34(20):5815-28.
2005: Aleksandra Trifunovic; Anna Hansson; Anna Wredenberg; Anja T Rovio; Eric Dufour; Ivan Khvorostov; Johannes N Spelbrink; Rolf Wibom; Howard T Jacobs; Nils-Göran Larsson
Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(50):17993-8.
2005: Carrie J Turner; Caroline Granycome; Rachel Hurst; Elizabeth Pohler; M Katariina Juhola; Martti I Juhola; Howard T Jacobs; Lesley Sutherland; Ian J Holt
Systematic segregation to mutant mitochondrial DNA and accompanying loss of mitochondrial DNA in human NT2 teratocarcinoma Cybrids.
Genetics 2005;170(4):1879-85.
2005: Takehiro Yasukawa; Ming Yao Yang; Howard T Jacobs; Ian J Holt
A bidirectional origin of replication maps to the major noncoding region of human mitochondrial DNA.
Molecular cell 2005;18(6):651-62.
2005: Howard T Jacobs; Douglass M Turnbull
Nuclear genes and mitochondrial translation: a new class of genetic disease.
Trends in genetics : TIG 2005;21(6):312-4.
2005: Takehiro Yasukawa; Yohei Kirino; Norie Ishii; Ian J Holt; Howard T Jacobs; Takao Makifuchi; Nobuyoshi Fukuhara; Shigeo Ohta; Tsutomu Suzuki; Kimitsuna Watanabe
Wobble modification deficiency in mutant tRNAs in patients with mitochondrial diseases.
FEBS letters 2005;579(13):2948-52.
2005: Howard T Jacobs; Tim Hutchin; Timo Käppi; Greta Gillies; Kia Minkkinen; John Walker; Karen Thompson; Anja T Rovio; Massimo Carella; Salvatore Melchionda; Leopoldo Zelante; Paolo Gasparini; Ilmari Pyykkö; Zahid Hussain Shah; Massimo Zeviani; Robert F Mueller
Mitochondrial DNA mutations in patients with postlingual, nonsyndromic hearing impairment.
European journal of human genetics : EJHG 2005;13(1):26-33.
2004: Howard T Jacobs; Daniel J M Fernández-Ayala; Shweta Manjiry; Esko Kemppainen; Janne Toivonen; Kevin M C O'Dell
Mitochondrial disease in flies.
Biochimica et biophysica acta 2004;1659(2-3):190-6.
2004: Marina Toompuu; Louis L Levinger; Anna Nadal; Jordi Gomez; Howard T Jacobs
The 7472insC mtDNA mutation impairs 5' and 3' processing of tRNA(Ser(UCN)).
Biochemical and biophysical research communications 2004;322(3):803-13.
2004: Anja T Rovio; Josef Abel; Arja L Ahola; Aida M Andres; Jaume Bertranpetit; Antoine Blancher; Ronald E Bontrop; Leona G Chemnick; Howard J Cooke; Jim Cummins; Heidi A Davis; David J Elliott; Ellen Fritsche; Timothy B Hargreave; Susan M G Hoffman; Anne M Jequier; Shu-Huei Kao; Heui-Soo Kim; David R Marchington; Denise Mehmet; Nel Otting; Joanna Poulton; Oliver A Ryder; Hans-Christian Schuppe; Osamu Takenaka; Yau-Huei Wei; Lars Wichmann; Howard T Jacobs
A prevalent POLG CAG microsatellite length allele in humans and African great apes.
Mammalian genome : official journal of the International Mammalian Genome Society 2004;15(6):492-502.
2004: Aleksandra Trifunovic; Anna Wredenberg; Maria Falkenberg; Johannes N Spelbrink; Anja T Rovio; Carl Bruder; Mohammad Bohlooly-Y; Sebastian Gidlöf; Anders Oldfors; Rolf Wibom; Jan Törnell; Howard T Jacobs; Nils-Göran Larsson
Premature ageing in mice expressing defective mitochondrial DNA polymerase.
Nature 2004;429(6990):417-23.
2003: Mark Bowmaker; Ming Yao Yang; Takehiro Yasukawa; Aurelio Reyes; Howard T Jacobs; Joel A Huberman; Ian J Holt
Mammalian mitochondrial DNA replicates bidirectionally from an initiation zone.
The Journal of biological chemistry 2003;278(51):50961-9.
2003: Howard T Jacobs
Disorders of mitochondrial protein synthesis.
Human molecular genetics 2003;12 Spec No 2():R293-301.
2003: Janne Toivonen; Shweta Manjiry; Sylvie Touraille; Serge Alziari; Kevin M C O'Dell; Howard T Jacobs
Gene dosage and selective expression modify phenotype in a Drosophila model of human mitochondrial disease.
Mitochondrion 2003;3(2):83-96.
2003: Ian J Holt; Howard T Jacobs
Response: The mitochondrial DNA replication bubble has not burst.
Trends in biochemical sciences 2003;28(7):355-6.
2003: Howard T Jacobs
Rebuttal to Pak et al.: new data, chestnuts.
Aging cell 2003;2(1):19-20.
2003: Howard T Jacobs
The mitochondrial theory of aging: dead or alive?
Aging cell 2003;2(1):11-7.
2002: Ming Yao Yang; Mark Bowmaker; Aurelio Reyes; Lodovica Vergani; Paolo Angeli; Enrico Gringeri; Howard T Jacobs; Ian J Holt
Biased incorporation of ribonucleotides on the mitochondrial L-strand accounts for apparent strand-asymmetric DNA replication.
Cell 2002;111(4):495-505.
2002: Marina Toompuu; Takehiro Yasukawa; Tsutomu Suzuki; Terhi Hakkinen; Johannes N Spelbrink; Kimitsuna Watanabe; Howard T Jacobs
The 7472insC mitochondrial DNA mutation impairs the synthesis and extent of aminoacylation of tRNASer(UCN) but not its structure or rate of turnover.
The Journal of biological chemistry 2002;277(25):22240-50.
2002: Olli A Kajander; Pekka J Karhunen; Howard T Jacobs
The relationship between somatic mtDNA rearrangements, human heart disease and aging.
Human molecular genetics 2002;11(3):317-24.
2001: Olli A Kajander; Pekka J Karhunen; Ian J Holt; Howard T Jacobs
Prominent mitochondrial DNA recombination intermediates in human heart muscle.
EMBO reports 2001;2(11):1007-12.
2001: Anja T Rovio; David R Marchington; S Donat; Hans-Christian Schuppe; J Abel; Ellen Fritsche; David J Elliott; P Laippala; A L Ahola; D McNay; R F Harrison; B Hughes; T Barrett; D M Bailey; Denise Mehmet; Anne M Jequier; Timothy B Hargreave; S H Kao; Jim Cummins; David Barton; H J Cooke; Y H Wei; L Wichmann; Joanna Poulton; Howard T Jacobs
Mutations at the mitochondrial DNA polymerase (POLG) locus associated with male infertility.
Nature genetics 2001;29(3):261-2.
2001: Howard T Jacobs
Making mitochondrial mutants.
Trends in genetics : TIG 2001;17(11):653-60.
2001: Janne Toivonen; Kevin M C O'Dell; Nathalie Petit; S C Irvine; G K Knight; M Lehtonen; M Longmuir; K Luoto; Sylvie Touraille; Z Wang; Serge Alziari; Zahid Hussain Shah; Howard T Jacobs
Technical knockout, a Drosophila model of mitochondrial deafness.
Genetics 2001;159(1):241-54.
2001: Johannes N Spelbrink; FY Li; Valeria Tiranti; Kaisu Nikali; Qiu-Ping Yuan; M Tariq; Sjoerd Wanrooij; Nuria Garrido; G Comi; L Morandi; L Santoro; A Toscano; G M Fabrizi; Hannu Somer; Rebecca Croxen; David Beeson; Joanna Poulton; Anu Suomalainen; Howard T Jacobs; Massimo Zeviani; Catharina Larsson
Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria.
Nature genetics 2001;28(3):223-31.
2001: Zahid Hussain Shah; Marina Toompuu; T Hakkinen; Anja T Rovio; C van Ravenswaay; E M De Leenheer; R J Smith; F P Cremers; C W Cremers; Howard T Jacobs
Novel coding-region polymorphisms in mitochondrial seryl-tRNA synthetase (SARSM) and mitoribosomal protein S12 (RPMS12) genes in DFNA4 autosomal dominant deafness families.
Human mutation 2001;17(5):433-4.
2000: Olli A Kajander; Anja T Rovio; K Majamaa; Joanna Poulton; Johannes N Spelbrink; Ian J Holt; Pekka J Karhunen; Howard T Jacobs
Human mtDNA sublimons resemble rearranged mitochondrial genoms found in pathological states.
Human molecular genetics 2000;9(19):2821-35.
2000: M K Juhola; Zahid Hussain Shah; Les Grivell; Howard T Jacobs
The mitochondrial inner membrane AAA metalloprotease family in metazoans.
FEBS letters 2000;481(2):91-5.
2000: Johannes N Spelbrink; Janne Toivonen; Gerrit A J Hakkaart; J M Kurkela; H M Cooper; Saara Lehtinen; N Lecrenier; Jaap Willem Back; Dave Speijer; Françoise Foury; Howard T Jacobs
In vivo functional analysis of the human mitochondrial DNA polymerase POLG expressed in cultured human cells.
The Journal of biological chemistry 2000;275(32):24818-28.
2000: Zahid Hussain Shah; Gerrit A J Hakkaart; B Arku; Luitzen de Jong; Hans Van Der Spek; Les Grivell; Howard T Jacobs
The human homologue of the yeast mitochondrial AAA metalloprotease Yme1p complements a yeast yme1 disruptant.
FEBS letters 2000;478(3):267-70.
2000: Howard T Jacobs; Saara Lehtinen; Johannes N Spelbrink
No sex please, we're mitochondria: a hypothesis on the somatic unit of inheritance of mammalian mtDNA.
BioEssays : news and reviews in molecular, cellular and developmental biology 2000;22(6):564-72.
2000: Ian J Holt; H E Lorimer; Howard T Jacobs
Coupled leading- and lagging-strand synthesis of mammalian mitochondrial DNA.
Cell 2000;100(5):515-24.
2000: Howard T Jacobs; Ian J Holt
The np 3243 MELAS mutation: damned if you aminoacylate, damned if you don't.
Human molecular genetics 2000;9(4):463-5.
2000: Saara Lehtinen; N Hance; A El Meziane; M K Juhola; K M Juhola; R Karhu; Johannes N Spelbrink; Ian J Holt; Howard T Jacobs
Genotypic stability, segregation and selection in heteroplasmic human cell lines containing np 3243 mutant mtDNA.
Genetics 2000;154(1):363-80.
1999: P Mariottini; Zahid Hussain Shah; Janne Toivonen; Claudia Bagni; Johannes N Spelbrink; Francesco Amaldi; Howard T Jacobs
Expression of the gene for mitoribosomal protein S12 is controlled in human cells at the levels of transcription, RNA splicing, and translation.
The Journal of biological chemistry 1999;274(45):31853-62.
1999: Saara Lehtinen; Johannes N Spelbrink; Howard T Jacobs
Heteroplasmic segregation associated with trisomy-9 in cultured human cells.
Somatic cell and molecular genetics 1999;25(5-6):263-74.
1999: Marina Toompuu; Valeria Tiranti; M Zeviani; Howard T Jacobs
Molecular phenotype of the np 7472 deafness-associated mitochondrial mutation in osteosarcoma cell cybrids.
Human molecular genetics 1999;8(12):2275-83.
1999: Janne Toivonen; M R Boocock; Howard T Jacobs
Modelling in Escherichia coli of mutations in mitoribosomal protein S12: novel mutant phenotypes of rpsL.
Molecular microbiology 1999;31(6):1735-46.
1999: Robert N Lightowlers; Howard T Jacobs; Olli A Kajander
Mitochondrial DNA--all things bad?
Trends in genetics : TIG 1999;15(3):91-3.
1999: Anja T Rovio; Valeria Tiranti; AL Bednarz; Anu Suomalainen; Johannes N Spelbrink; N Lecrenier; Atle Melberg; Massimo Zeviani; Joanna Poulton; Françoise Foury; Howard T Jacobs
Analysis of the trinucleotide CAG repeat from the human mitochondrial DNA polymerase gene in healthy and diseased individuals.
European journal of human genetics : EJHG 1999;7(2):140-6.
1999: Olli A Kajander; Tarja A Kunnas; Markus Perola; Saara Lehtinen; Pekka J Karhunen; Howard T Jacobs
Long-extension PCR to detect deleted mitochondrial DNA molecules is compromized by technical artefacts.
Biochemical and biophysical research communications 1999;254(2):507-14.
1998: A El Meziane; Saara Lehtinen; Ian J Holt; Howard T Jacobs
Mitochondrial tRNALeu isoforms in lung carcinoma cybrid cells containing the np 3243 mtDNA mutation.
Human molecular genetics 1998;7(13):2141-7.
1998: A El Meziane; Saara Lehtinen; N Hance; Leo G J Nijtmans; D Dunbar; Ian J Holt; Howard T Jacobs
A tRNA suppressor mutation in human mitochondria.
Nature genetics 1998;18(4):350-3.
1998: Zahid Hussain Shah; V Migliosi; S C Miller; A Wang; T B Friedman; Howard T Jacobs
Chromosomal locations of three human nuclear genes (RPSM12, TUFM, and AFG3L1) specifying putative components of the mitochondrial gene expression apparatus.
Genomics 1998;48(3):384-8.
1998: Johannes N Spelbrink; M J Van Galen; R Zwart; H D Bakker; Anja T Rovio; Howard T Jacobs; C Van den Bogert
Familial mitochondrial DNA depletion in liver: haplotype analysis of candidate genes.
Human genetics 1998;102(3):327-31.
1997: Zahid Hussain Shah; Kevin M C O'Dell; S C Miller; X An; Howard T Jacobs
Metazoan nuclear genes for mitoribosomal protein S12.
Gene 1997;204(1-2):55-62.
1997: Howard T Jacobs
Mitochondrial deafness.
Annals of medicine 1997;29(6):483-91.
1997: Kai Krohn; Vladimir Ovod; P Vilja; M Heino; H Scott; D S Kyriakou; Stylianos E Antonarakis; Howard T Jacobs; J Isola; Pärt Peterson
Immunochemical characterization of a novel mitochondrially located protein encoded by a nuclear gene within the DFNB8/10 critical region on 21q22.3.
Biochemical and biophysical research communications 1997;238(3):806-10.
1997: Ian J Holt; Donald Dunbar; Howard T Jacobs
Behaviour of a population of partially duplicated mitochondrial DNA molecules in cell culture: segregation, maintenance and recombination dependent upon nuclear background.
Human molecular genetics 1997;6(8):1251-60.
1997: F M Reid; Anja T Rovio; Ian J Holt; Howard T Jacobs
Molecular phenotype of a human lymphoblastoid cell-line homoplasmic for the np 7445 deafness-associated mitochondrial mutation.
Human molecular genetics 1997;6(3):443-9.
1995: Joyce Moore; Howard T Jacobs; K Kaiser
The relationship between mRNA half-life and gene function in the yeast Saccharomyces cerevisiae.
Gene 1995;166(1):145-9.
1995: Donald Dunbar; P A Moonie; Howard T Jacobs; Ian J Holt
Different cellular backgrounds confer a marked advantage to either mutant or wild-type mitochondrial genomes.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(14):6562-6.
1995: J Moore; Howard T Jacobs; K Kaiser
Characterisation of Saccharomyces cerevisiae genes encoding ribosomal protein YL6.
Molecular & general genetics : MGG 1995;247(2):247-54.
1995: L Sutherland; J Davidson; L L Glass; Howard T Jacobs
Multisite oligonucleotide-mediated mutagenesis: application to the conversion of a mitochondrial gene to universal genetic code.
BioTechniques 1995;18(3):458-64.
1994: R Sewards; B Wiseman; Howard T Jacobs
Apparent functional independence of the mitochondrial and nuclear transcription systems in cultured human cells.
Molecular & general genetics : MGG 1994;245(6):760-8.
1994: L Sutherland; J Davidson; Howard T Jacobs
Nuclear expression of mitochondrial genes implicated in human encephalomyopathies.
Biochemical Society transactions 1994;22(4):413S.
1994: G A Vernham; F M Reid; P A Rundle; Howard T Jacobs
Bilateral sensorineural hearing loss in members of a maternal lineage with mitochondrial point mutation.
Clinical otolaryngology and allied sciences 1994;19(4):314-9.
1994: F M Reid; G A Vernham; Howard T Jacobs
Complete mtDNA sequence of a patient in a maternal pedigree with sensorineural deafness.
Human molecular genetics 1994;3(8):1435-6.
1994: F M Reid; G A Vernham; Howard T Jacobs
A novel mitochondrial point mutation in a maternal pedigree with sensorineural deafness.
Human mutation 1994;3(3):243-7.
1993: S A Qureshi; Howard T Jacobs
Two distinct, sequence-specific DNA-binding proteins interact independently with the major replication pause region of sea urchin mtDNA.
Nucleic acids research 1993;21(12):2801-8.
1993: S A Qureshi; Howard T Jacobs
Characterization of a high-affinity binding site for a DNA-binding protein from sea urchin embryo mitochondria.
Nucleic acids research 1993;21(4):811-6.
1992: A G Mayhook; A M Rinaldi; Howard T Jacobs
Replication origins and pause sites in sea urchin mitochondrial DNA.
Proceedings. Biological sciences / The Royal Society 1992;248(1321):85-94.
1991: A el Meziane; Howard T Jacobs
Mitochondrial base prediction.
Nature 1991;351(6323):194.
1991: Howard T Jacobs
Structural similarities between a mitochondrially encoded polypeptide and a family of prokaryotic respiratory toxins involved in plasmid maintenance suggest a novel mechanism for the evolutionary maintenance of mitochondrial DNA.
Journal of molecular evolution 1991;32(4):333-9.
1989: Howard T Jacobs; E R Herbert; J Rankine
Sea urchin egg mitochondrial DNA contains a short displacement loop (D-loop) in the replication origin region.
Nucleic acids research 1989;17(22):8949-65.
1989: Howard T Jacobs; S Asakawa; T Araki; K Miura; M J Smith; K Watanabe
Conserved tRNA gene cluster in starfish mitochondrial DNA.
Current genetics 1989;15(3):193-206.
1989: D J Elliott; Howard T Jacobs
Mutually exclusive synthetic pathways for sea urchin mitochondrial rRNA and mRNA.
Molecular and cellular biology 1989;9(3):1069-82.
1988: Howard T Jacobs; D J Elliott; V B Math; A Farquharson
Nucleotide sequence and gene organization of sea urchin mitochondrial DNA.
Journal of molecular biology 1988;202(2):185-217.