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Ian Jacobs

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Adam N Rosenthal; Naveena Singh; Steven J Skates; James Mackay; Ranjit Manchanda; Usha Menon; Jessica Mozersky; Susan Philpott; Philip Badman; Elizabeth Benjamin; Fay H Cafferty; Diana M Eccles; D Gareth Evans; Lindsay Fraser; Richard Hadwin; Ian J Jacobs
Results of annual screening in phase I of the United Kingdom familial ovarian cancer screening study highlight the need for strict adherence to screening schedule.
Joanna Zhuang; Michal Zikan; David Cibula; Heidi Fiegl; Ian J Jacobs; Allison Jones; Henry C Kitchener; Shih-Han Lee; Esther Ng; Helga B Salvesen; Alexandra Sargent; Andrew E Teschendorff; Martin Widschwendter
The dynamics and prognostic potential of DNA methylation changes at stem cell gene loci in women's cancer.
Kate Lawrenson; Maria Notaridou; Andrew Sims; Duncan Sproul; Elizabeth Benjamin; Dimitra Dafou; Barbara Grun; Ian J Jacobs; Simon A Gayther
Modelling genetic and clinical heterogeneity in epithelial ovarian cancers.

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All Publications

2013: Adam N Rosenthal; Naveena Singh; Steven J Skates; James Mackay; Ranjit Manchanda; Usha Menon; Jessica Mozersky; Susan Philpott; Philip Badman; Elizabeth Benjamin; Fay H Cafferty; Diana M Eccles; D Gareth Evans; Lindsay Fraser; Richard Hadwin; Ian J Jacobs
Results of annual screening in phase I of the United Kingdom familial ovarian cancer screening study highlight the need for strict adherence to screening schedule.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2013;31(1):49-57.
2012: Joanna Zhuang; Michal Zikan; David Cibula; Heidi Fiegl; Ian J Jacobs; Allison Jones; Henry C Kitchener; Shih-Han Lee; Esther Ng; Helga B Salvesen; Alexandra Sargent; Andrew E Teschendorff; Martin Widschwendter
The dynamics and prognostic potential of DNA methylation changes at stem cell gene loci in women's cancer.
PLoS genetics 2012;8(2):e1002517.
2011: Kate Lawrenson; Maria Notaridou; Andrew Sims; Duncan Sproul; Elizabeth Benjamin; Dimitra Dafou; Barbara Grun; Ian J Jacobs; Simon A Gayther
Modelling genetic and clinical heterogeneity in epithelial ovarian cancers.
Carcinogenesis 2011;32(10):1540-9.
2011: Nyaladzi Balogun; Aleksandra Gentry-Maharaj; Eva L Wozniak; Anita Lim; Andy Ryan; Susan J Ramus; Jeremy Ford; Matthew Burnell; Martin Widschwendter; Sue F Gessler; Simon A Gayther; Ian J Jacobs; Usha Menon
Recruitment of newly diagnosed ovarian cancer patients proved challenging in a multicentre biobanking study.
Journal of clinical epidemiology 2011;64(5):525-30.
2010: Dimitra Dafou; Barbara Grun; John Sinclair; Kate Lawrenson; Elizabeth C Benjamin; Estrid Hogdall; Susanne Kruger-Kjaer; Lise Christensen; Heidi M Sowter; Ahmed Al-Attar; Richard Edmondson; Stephen Darby; Andrew Berchuck; Peter W Laird; Celeste L Pearce; Susan J Ramus; Ian J Jacobs; Simon A Gayther
Microcell-mediated chromosome transfer identifies EPB41L3 as a functional suppressor of epithelial ovarian cancers.
Neoplasia (New York, N.Y.) 2010;12(7):579-89.
2010: Kate Lawrenson; Barbara Grun; Elizabeth Benjamin; Ian J Jacobs; Dimitra Dafou; Simon A Gayther
Senescent fibroblasts promote neoplastic transformation of partially transformed ovarian epithelial cells in a three-dimensional model of early stage ovarian cancer.
Neoplasia (New York, N.Y.) 2010;12(4):317-25.
2010: Andrew E Teschendorff; Usha Menon; Aleksandra Gentry-Maharaj; Susan J Ramus; Daniel J Weisenberger; Hui Shen; Mihaela Campan; Houtan Noushmehr; Christopher G Bell; A Peter Maxwell; David A Savage; Elisabeth Mueller-Holzner; Christian Marth; Gabrijela Kocjan; Simon A Gayther; Allison Jones; Stephan Beck; Wolfgang Wagner; Peter W Laird; Ian J Jacobs; Martin Widschwendter
Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer.
Genome research 2010;20(4):440-6.
2009: Sophia Apostolidou; Richard Hadwin; Matthew Burnell; Allison Jones; Donna Baff; Nitisha Pyndiah; Tim Mould; Ian J Jacobs; Simon Beddows; Gabrijela Kocjan; Martin Widschwendter
DNA methylation analysis in liquid-based cytology for cervical cancer screening.
International journal of cancer. Journal international du cancer 2009;125(12):2995-3002.
2009: Martin Widschwendter; Sophia Apostolidou; Allison A Jones; Evangelia O Fourkala; Rupali Arora; Celeste L Pearce; Melissa A Frasco; Ayse Ayhan; Michal Zikan; David Cibula; Cem A Iyibozkurt; Ekrem Yavuz; Cornelia Hauser-Kronberger; Louis Dubeau; Usha Menon; Ian J Jacobs
HOXA methylation in normal endometrium from premenopausal women is associated with the presence of ovarian cancer: a proof of principle study.
International journal of cancer. Journal international du cancer 2009;125(9):2214-8.
2009: Martin Widschwendter; H Lichtenberg-Frate; G Hasenbrink; S Schwarzer; Anne Dawnay; A Lam; Usha Menon; S Apostolidou; E Raum; C Stegmaier; Ian J Jacobs; H Brenner
Serum oestrogen receptor alpha and beta bioactivity are independently associated with breast cancer: a proof of principle study.
British journal of cancer 2009;101(1):160-5.
2009: Lalarukh Khalique; Ayse Ayhan; John C Whittaker; Naveena Singh; Ian J Jacobs; Simon A Gayther; Susan J Ramus
The clonal evolution of metastases from primary serous epithelial ovarian cancers.
International journal of cancer. Journal international du cancer 2009;124(7):1579-86.
2009: L Quaye; Honglin Song; Susan J Ramus; A Gentry-Maharaj; E Høgdall; Richard A DiCioccio; V McGuire; A H Wu; D J Van Den Berg; Malcolm Pike; E Wozniak; J A Doherty; M A Rossing; R B Ness; K B Moysich; C Høgdall; J Blaakaer; Douglas F Easton; bruce ponder; Ian J Jacobs; Usha Menon; Alice S Whittemore; S Krüger-Kjaer; Celeste L Pearce; Paul D P Pharoah; Simon A Gayther
Tagging single-nucleotide polymorphisms in candidate oncogenes and susceptibility to ovarian cancer.
British journal of cancer 2009;100(6):993-1001.
2009: Andrew E Teschendorff; Usha Menon; Aleksandra Gentry-Maharaj; Susan J Ramus; Simon A Gayther; Sophia Apostolidou; Allison Jones; Matthias Lechner; Stephan Beck; Ian J Jacobs; Martin Widschwendter
An epigenetic signature in peripheral blood predicts active ovarian cancer.
PloS one 2009;4(12):e8274.
2008: Susan J Ramus; Karim Elmasry; Zhiyuan Luo; Alex Gammerman; Karen Lu; Ayse Ayhan; Naveena Singh; W Glenn McCluggage; Ian J Jacobs; John C Whittaker; Simon A Gayther
Predicting clinical outcome in patients diagnosed with synchronous ovarian and endometrial cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(18):5840-8.
2008: Chung Sim Lim; Farhad Alexander-Sefre; Mohamed Allam; Naveena Singh; Joanne Chin Aleong; Haytham Al-Rawi; Ian J Jacobs
Clinical value of immunohistochemically detected lymphovascular space invasion in early stage cervical carcinoma.
Annals of surgical oncology 2008;15(9):2581-8.
2008: Estrid V S Høgdall; Lise Christensen; Susanne K Kjaer; Jan Blaakaer; Ib Jarle Christensen; Simon Gayther; Ian J Jacobs; Claus K Høgdall
Protein expression levels of carcinoembryonic antigen (CEA) in Danish ovarian cancer patients: from the Danish 'MALOVA'ovarian cancer study.
Pathology 2008;40(5):487-92.
2008: Heidi Fiegl; Gudrun Windbichler; Elisabeth Mueller-Holzner; Georg Goebel; Matthias Lechner; Ian J Jacobs; Martin Widschwendter
HOXA11 DNA methylation--a novel prognostic biomarker in ovarian cancer.
International journal of cancer. Journal international du cancer 2008;123(3):725-9.
2008: James A Morris; Simon A Gayther; Ian J Jacobs; Christopher Jones
A suite of Perl modules for handling microarray data.
Bioinformatics (Oxford, England) 2008;24(8):1102-3.
2008: Martin Widschwendter; Sophia Apostolidou; Elke Raum; Dietrich Rothenbacher; Heidi Fiegl; Usha Menon; Christa Stegmaier; Ian J Jacobs; Hermann Brenner
Epigenotyping in peripheral blood cell DNA and breast cancer risk: a proof of principle study.
PloS one 2008;3(7):e2656.
2008: Will Stott; Andy Ryan; Ian J Jacobs; Usha Menon; Conrad Bessant; Christopher Jones
OSPACS: Ultrasound image management system.
Source code for biology and medicine 2008;3():11.
2008: James A Morris; Simon A Gayther; Ian J Jacobs; Christopher Jones
A Perl toolkit for LIMS development.
Source code for biology and medicine 2008;3():4.
2007: Zhen Zhang; Yinhua Yu; Fengji Xu; Andrew Berchuck; Carolien Van Haaften-Day; Laura Havrilesky; Henk W A de Bruijn; Ate G J van der Zee; Robert P Woolas; Ian J Jacobs; Steven J Skates; Daniel W Chan; Robert C Bast
Combining multiple serum tumor markers improves detection of stage I epithelial ovarian cancer.
Gynecologic oncology 2007;107(3):526-31.
2007: Susan J Ramus; Patricia A Harrington; Carole Pye; Richard A DiCioccio; Mark J Cox; Kim Garlinghouse-Jones; Ingrid Oakley-Girvan; Ian J Jacobs; Richard M Hardy; Alice S Whittemore; Bruce A J Ponder; M Steven Piver; Paul D P Pharoah; Simon A Gayther
Contribution of BRCA1 and BRCA2 mutations to inherited ovarian cancer.
Human mutation 2007;28(12):1207-15.
2007: Estrid V S Høgdall; Lise Christensen; Claus K Høgdall; Jan Blaakaer; Simon A Gayther; Ian J Jacobs; Ib Jarle Christensen; Susanne Krüger Kjaer
Prognostic value of estrogen receptor and progesterone receptor tumor expression in Danish ovarian cancer patients: from the 'MALOVA' ovarian cancer study.
Oncology reports 2007;18(5):1051-9.
2007: Estrid V S Høgdall; Lise Christensen; Susanne Krüger Kjaer; Jan Blaakaer; Ib Jarle Christensen; Simon A Gayther; Ian J Jacobs; Claus K Høgdall
Expression level of Wilms tumor 1 (WT1) protein has limited prognostic value in epithelial ovarian cancer: from the Danish "MALOVA" ovarian cancer study.
Gynecologic oncology 2007;106(2):318-24.
2007: Susan J Ramus; Patricia A Harrington; Carole Pye; Susan Peock; Margaret R Cook; Mark J Cox; Ian J Jacobs; Richard A DiCioccio; Alice S Whittemore; M Steven Piver; Douglas F Easton; Bruce A J Ponder; Paul D P Pharoah; Simon A Gayther
Screening for the BRCA1-ins6kbEx13 mutation: potential for misdiagnosis. Mutation in brief #964. Online.
Human mutation 2007;28(5):525-6.
2007: Estrid V S Høgdall; Lise Christensen; Susanne Krüger Kjaer; Jan Blaakaer; Anette Kjaerbye-Thygesen; Simon A Gayther; Ian J Jacobs; Claus K Høgdall
CA125 expression pattern, prognosis and correlation with serum CA125 in ovarian tumor patients. From The Danish "MALOVA" Ovarian Cancer Study.
Gynecologic oncology 2007;104(3):508-15.
2007: L Khalique; A Ayhan; Michael E Weale; Ian J Jacobs; Susan J Ramus; Simon A Gayther
Genetic intra-tumour heterogeneity in epithelial ovarian cancer and its implications for molecular diagnosis of tumours.
The Journal of pathology 2007;211(3):286-95.
2007: Honglin Song; Susan J Ramus; Susanne Krüger Kjaer; Estrid Hogdall; Richard A DiCioccio; Alice S Whittemore; Valerie McGuire; Claus Hogdall; Ian J Jacobs; Douglas F Easton; Bruce A J Ponder; Alison M Dunning; Simon A Gayther; Paul D P Pharoah
Tagging single nucleotide polymorphisms in the BRIP1 gene and susceptibility to breast and ovarian cancer.
PloS one 2007;2(3):e268.
2007: Philippe O van Trappen; Barnaby Rufford; T D Mills; S A A Sohaib; J A W Webb; Anju Sahdev; MJ Carroll; Keith E Britton; Rodney H Reznek; Ian J Jacobs
Differential diagnosis of adnexal masses: risk of malignancy index, ultrasonography, magnetic resonance imaging, and radioimmunoscintigraphy.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2007;17(1):61-7.
2007: Barnaby Rufford; Ian J Jacobs; U Menon
Feasibility of screening for ovarian cancer using symptoms as selection criteria.
BJOG : an international journal of obstetrics and gynaecology 2007;114(1):59-64.
2007: Philippe O van Trappen; Tom Cullup; R Troke; D Swann; John H Shepherd; Ian J Jacobs; Simon A Gayther; Charles A Mein
Somatic mitochondrial DNA mutations in primary and metastatic ovarian cancer.
Gynecologic oncology 2007;104(1):129-33.
2006: Ian J Jacobs; James Mackay; Usha Menon; Steven J Skates; Adam N Rosenthal; L Fraser
Familial ovarian screening--effective or ineffective?
British journal of cancer 2006;95(8):1124; author reply 1126-7.
2006: Honglin Song; Susan J Ramus; Danielle Shadforth; Lydia Quaye; Susanne Krüger Kjaer; Richard A DiCioccio; Alison M Dunning; Estrid Hogdall; Claus Hogdall; Alice S Whittemore; Valerie McGuire; Fabienne LESUEUR; Douglas F Easton; Ian J Jacobs; Bruce A J Ponder; Simon A Gayther; Paul D P Pharoah
Common variants in RB1 gene and risk of invasive ovarian cancer.
Cancer research 2006;66(20):10220-6.
2006: Adam N Rosenthal; Usha Menon; Ian J Jacobs
Screening for ovarian cancer.
Clinical obstetrics and gynecology 2006;49(3):433-47.
2006: Andrea G Rockall; S Ghosh; Farhad Alexander-Sefre; Syed A Babar; M T S Younis; S Naz; Ian J Jacobs; Rodney H Reznek
Can MRI rule out bladder and rectal invasion in cervical cancer to help select patients for limited EUA?
Gynecologic oncology 2006;101(2):244-9.
2005: Usha Menon; Steven J Skates; Sara Lewis; Adam N Rosenthal; Barnaby Rufford; Karen Sibley; Nicola MacDonald; Anne Dawnay; Arjun Jeyarajah; Robert C Bast; David H Oram; Ian J Jacobs
Prospective study using the risk of ovarian cancer algorithm to screen for ovarian cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(31):7919-26.
2005: Helga B Salvesen; Rajiv Kumar; Ingunn M Stefansson; Sabrina Angelini; Nicola MacDonald; Johanna Smeds; Ian J Jacobs; Kari Hemminki; Soma Das; Lars A Akslen
Low frequency of BRAF and CDKN2A mutations in endometrial cancer.
International journal of cancer. Journal international du cancer 2005;115(6):930-4.
2005: Andrea G Rockall; S A A Sohaib; Mukesh G Harisinghani; Syed A Babar; Naveena Singh; Arjun Jeyarajah; David H Oram; Ian J Jacobs; John H Shepherd; Rodney H Reznek
Diagnostic performance of nanoparticle-enhanced magnetic resonance imaging in the diagnosis of lymph node metastases in patients with endometrial and cervical cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(12):2813-21.
2005: S A A Sohaib; T D Mills; Anju Sahdev; J A W Webb; P O Vantrappen; Ian J Jacobs; Rodney H Reznek
The role of magnetic resonance imaging and ultrasound in patients with adnexal masses.
Clinical radiology 2005;60(3):340-8.
2004: Helga B Salvesen; Ingunn M Stefansson; Ellen I Kretzschmar; Paula Gruber; Nicola D Macdonald; Andy Ryan; Ian J Jacobs; Lars A Akslen; Soma Das
Significance of PTEN alterations in endometrial carcinoma: a population-based study of mutations, promoter methylation and PTEN protein expression.
International journal of oncology 2004;25(6):1615-23.
2004: Steven J Skates; Nora K Horick; Yinhua Yu; Feng-Ji Xu; Andrew Berchuck; Laura Havrilesky; Henk W A de Bruijn; Ate G J van der Zee; Robert P Woolas; Ian J Jacobs; Zhen Zhang; Robert C Bast
Preoperative sensitivity and specificity for early-stage ovarian cancer when combining cancer antigen CA-125II, CA 15-3, CA 72-4, and macrophage colony-stimulating factor using mixtures of multivariate normal distributions.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(20):4059-66.
2004: Dirk Brinkmann; Andy Ryan; Ayse Ayhan; W Glen McCluggage; Roger M Feakins; Mauro F Santibanez-Koref; Charles A Mein; Simon A Gayther; Ian J Jacobs
A molecular genetic and statistical approach for the diagnosis of dual-site cancers.
Journal of the National Cancer Institute 2004;96(19):1441-6.
2004: Richard A DiCioccio; Honglin Song; Christy Waterfall; Makoto T Kimura; Hiroki Nagase; Valerie McGuire; Estrid Hogdall; Mitul N Shah; Robert N Luben; Douglas F Easton; Ian J Jacobs; Bruce A J Ponder; Alice S Whittemore; Simon A Gayther; Paul D P Pharoah; Susan Kruger-Kjaer
STK15 polymorphisms and association with risk of invasive ovarian cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2004;13(10):1589-94.
2004: Nicola D Macdonald; Helga B Salvesen; Andy Ryan; S Malatos; Ingunn M Stefansson; Ole-Erik Iversen; Lars A Akslen; Soma Das; Ian J Jacobs
Molecular differences between RER+ and RER- sporadic endometrial carcinomas in a large population-based series.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2004;14(5):957-65.
2004: Zhen Zhang; Robert C Bast; Yinhua Yu; Jinong Li; Lori J Sokoll; Alex J Rai; Jason Rosenzweig; Bonnie Cameron; Young Y Wang; Xiao-Ying Meng; Andrew Berchuck; Carolien Van Haaften-Day; Neville F Hacker; Henk W A de Bruijn; Ate G J van der Zee; Ian J Jacobs; Eric T Fung; Daniel W Chan
Three biomarkers identified from serum proteomic analysis for the detection of early stage ovarian cancer.
Cancer research 2004;64(16):5882-90.
2004: Farhad Alexander-Sefre; Naveena Singh; A Ayhan; J M Thomas; Ian J Jacobs
Assessment of the depth of myometrial invasion in stage I endometrioid endometrial cancer using pancytokeratin immunohistochemistry.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2004;14(4):665-72.
2004: Ningfeng F Li; George D Wilbanks; Frances R Balkwill; Ian J Jacobs; Dimitra Dafou; Simon A Gayther
A modified medium that significantly improves the growth of human normal ovarian surface epithelial (OSE) cells in vitro.
Laboratory investigation; a journal of technical methods and pathology 2004;84(7):923-31.
2004: Estrid V S Høgdall; Andy Ryan; Susanne Krüger Kjaer; Jan Blaakaer; Lise Christensen; Johannes E Bock; Eva Glud; Ian J Jacobs; Claus K Høgdall
Loss of heterozygosity on the X chromosome is an independent prognostic factor in ovarian carcinoma: from the Danish "MALOVA" Ovarian Carcinoma Study.
Cancer 2004;100(11):2387-95.
2004: G Mehra; A R L Weekes; Ian J Jacobs; D Visvanathan; Usha Menon; Arjun Jeyarajah
Laparoscopic extraperitoneal paraaortic lymphadenectomy: a study of its applications in gynecological malignancies.
Gynecologic oncology 2004;93(1):189-93.
2004: Ian J Jacobs; Usha Menon
Progress and challenges in screening for early detection of ovarian cancer.
Molecular & cellular proteomics : MCP 2004;3(4):355-66.
2004: Farhad Alexander-Sefre; Naveena Singh; A Ayhan; J M Thomas; Ian J Jacobs
Clinical value of immunohistochemically detected lymphovascular invasion in endometrioid endometrial cancer.
Gynecologic oncology 2004;92(2):653-9.
2003: Philippe O van Trappen; Dawn Steele; David G Lowe; Suhail Baithun; Nigel J P Beasley; Wilko Thiele; Herbert A Weich; Jaya Krishnan; John H Shepherd; Michael S Pepper; David G Jackson; Jonathan P Sleeman; Ian J Jacobs
Expression of vascular endothelial growth factor (VEGF)-C and VEGF-D, and their receptor VEGFR-3, during different stages of cervical carcinogenesis.
The Journal of pathology 2003;201(4):544-54.
2003: Stephanie Halford; Elinor J Sawyer; Maryou B K Lambros; Patricia Gorman; Nicola D Macdonald; Ian C Talbot; William D Foulkes; Cheryl E Gillett; Diana M Barnes; Lars A Akslen; Kwok Lee; Ian J Jacobs; Andrew M Hanby; Trivadi Ganesan; Helga B Salvesen; Walter F Bodmer; Ian P M Tomlinson; Rebecca R Roylance
MSI-low, a real phenomenon which varies in frequency among cancer types.
The Journal of pathology 2003;201(3):389-94.
2003: Farhad Alexander-Sefre; Helga B Salvesen; Andy Ryan; Naveena Singh; Lars A Akslen; Nicolla MacDonald; George D Wilbanks; Ian J Jacobs
Molecular assessment of depth of myometrial invasion in stage I endometrial cancer: a model based on K-ras mutation analysis.
Gynecologic oncology 2003;91(1):218-25.
2003: Farhad Alexander-Sefre; Naveena Singh; A Ayhan; H B Salveson; George D Wilbanks; Ian J Jacobs
Detection of tumour lymphovascular space invasion using dual cytokeratin and CD31 immunohistochemistry.
Journal of clinical pathology 2003;56(10):786-8.
2003: Steven J Skates; Usha Menon; Nicola MacDonald; Adam N Rosenthal; David H Oram; Robert C Knapp; Ian J Jacobs
Calculation of the risk of ovarian cancer from serial CA-125 values for preclinical detection in postmenopausal women.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2003;21(10 Suppl):206s-210s.
2003: S A A Sohaib; Anju Sahdev; Philippe O van Trappen; Ian J Jacobs; Rodney H Reznek
Characterization of adnexal mass lesions on MR imaging.
AJR. American journal of roentgenology 2003;180(5):1297-304.
2003: Adam N Rosenthal; Deborah Hopster; Andy Ryan; Ian J Jacobs
Immunohistochemical analysis of p53 in vulval intraepithelial neoplasia and vulval squamous cell carcinoma.
British journal of cancer 2003;88(2):251-6.
2002: A P M Jongsma; Jurgen M J Piek; Ronald P Zweemer; René H M Verheijen; J W T Klein Gebbinck; G J van Kamp; Ian J Jacobs; P Shaw; Paulus van Diest; Peter Kenemans
Molecular evidence for putative tumour suppressor genes on chromosome 13q specific to BRCA1 related ovarian and fallopian tube cancer.
Molecular pathology : MP 2002;55(5):305-9.
2002: Patricia A Shaw; John R McLaughlin; Ronald P Zweemer; Steven A Narod; Harvey A Risch; René H M Verheijen; A Ryan; Fred H Menko; Peter Kenemans; Ian J Jacobs
Histopathologic features of genetically determined ovarian cancer.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2002;21(4):407-11.
2002: Philippe O van Trappen; A Ryan; M Carroll; C Lecoeur; Lindsey K Goff; VG Gyselman; Bryan D Young; David G Lowe; Michael S Pepper; John H Shepherd; Ian J Jacobs
A model for co-expression pattern analysis of genes implicated in angiogenesis and tumour cell invasion in cervical cancer.
British journal of cancer 2002;87(5):537-44.
2002: Adam N Rosenthal; Andy Ryan; Deborah Hopster; Ian J Jacobs
Molecular evidence of a common clonal origin and subsequent divergent clonal evolution in vulval intraepithelial neoplasia, vulval squamous cell carcinoma and lymph node metastases.
International journal of cancer. Journal international du cancer 2002;99(4):549-54.
2002: Farhad Alexander-Sefre; Usha Menon; Ian J Jacobs
Ovarian cancer screening.
Hospital medicine (London, England : 1998) 2002;63(4):210-3.
2002: S A A Sohaib; Polly S Richards; T E J Ind; Arjun Jeyarajah; John H Shepherd; Ian J Jacobs; Rodney H Reznek
MR imaging of carcinoma of the vulva.
AJR. American journal of roentgenology 2002;178(2):373-7.
2002: Ingunn M Stefansson; Lars A Akslen; Nicola MacDonald; Andy Ryan; Soma Das; Ian J Jacobs; Helga B Salvesen
Loss of hMSH2 and hMSH6 expression is frequent in sporadic endometrial carcinomas with microsatellite instability: a population-based study.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(1):138-43.
2001: Adam N Rosenthal; Andy Ryan; Deborah Hopster; T Surentheran; Ian J Jacobs
High frequency of loss of heterozygosity in vulval intraepithelial neoplasia (VIN) is associated with invasive vulval squamous cell carcinoma (VSCC).
International journal of cancer. Journal international du cancer 2001;94(6):896-900.
2001: L B Silberstein; Adam N Rosenthal; S W Coppack; K Noonan; Ian J Jacobs
Ascites and a raised serum Ca 125--confusing combination.
Journal of the Royal Society of Medicine 2001;94(11):581-2.
2001: Ronald P Zweemer; A Ryan; Antoine M Snijders; M A Hermsen; Gerrit A Meijer; U Beller; Fred H Menko; Ian J Jacobs; Jan P A Baak; René H M Verheijen; Peter Kenemans; Paulus van Diest
Comparative genomic hybridization of microdissected familial ovarian carcinoma: two deleted regions on chromosome 15q not previously identified in sporadic ovarian carcinoma.
Laboratory investigation; a journal of technical methods and pathology 2001;81(10):1363-70.
2001: Ronald P Zweemer; René H M Verheijen; J W Coebergh; Ian J Jacobs; Paulus van Diest; Johan J P Gille; S Skates; Fred H Menko; Leo P ten Kate; Peter Kenemans
Survival analysis in familial ovarian cancer, a case control study.
European journal of obstetrics, gynecology, and reproductive biology 2001;98(2):219-23.
2001: Donna K Pauler; Usha Menon; Martin McIntosh; H L Symecko; Steven J Skates; Ian J Jacobs
Factors influencing serum CA125II levels in healthy postmenopausal women.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2001;10(5):489-93.
2001: Usha Menon; Ian J Jacobs
Ovarian cancer screening in the general population.
Current opinion in obstetrics & gynecology 2001;13(1):61-4.
2001: Philippe O van Trappen; VG Gyselman; David G Lowe; A Ryan; David H Oram; P Bosze; A R Weekes; John H Shepherd; Sina Dorudi; Stephen Andrew Bustin; Ian J Jacobs
Molecular quantification and mapping of lymph-node micrometastases in cervical cancer.
Lancet 2001;357(9249):15-20.
2001: R P Zweemer; Ian J Jacobs
Familial ovarian cancer.
Methods in molecular medicine 2001;39():13-24.
2001: Ronald P Zweemer; Ian J Jacobs
Comment on Elit et al.: prophylactic oophorectomy in Ontario.
Familial cancer 2001;1(3-4):187-8.
2001: U Menon; Ian J Jacobs
Ovarian cancer screening in the general population: current status.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2001;11 Suppl 1():3-6.
2001: Helga B Salvesen; Nicola MacDonald; Andy Ryan; Ian J Jacobs; E D Lynch; Lars A Akslen; Soma Das
PTEN methylation is associated with advanced stage and microsatellite instability in endometrial carcinoma.
International journal of cancer. Journal international du cancer 2001;91(1):22-6.
2000: Estrid Hogdall; Claus K Høgdall; Solveig Tingulstad; Bjørn Hagen; Kjell Nustad; F J Xu; R C Bast; Ian J Jacobs
Predictive values of serum tumour markers tetranectin, OVX1, CASA and CA125 in patients with a pelvic mass.
International journal of cancer. Journal international du cancer 2000;89(6):519-23.
2000: Adam N Rosenthal; Andy Ryan; Deborah Hopster; Ian J Jacobs
p53 codon 72 polymorphism in vulval cancer and vulval intraepithelial neoplasia.
British journal of cancer 2000;83(10):1287-90.
2000: Usha Menon; Simon C Riley; J Thomas; C Bose; Anne Dawnay; LW Evans; nigel P groome; Ian J Jacobs
Serum inhibin, activin and follistatin in postmenopausal women with epithelial ovarian carcinoma.
BJOG : an international journal of obstetrics and gynaecology 2000;107(9):1069-74.
2000: Helga B Salvesen; Nicola MacDonald; Andy Ryan; Ole-Erik Iversen; Ian J Jacobs; Lars A Akslen; Soma Das
Methylation of hMLH1 in a population-based series of endometrial carcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(9):3607-13.
2000: Nicola D Macdonald; Helga B Salvesen; Andy Ryan; Ole-Erik Iversen; Lars A Akslen; Ian J Jacobs
Frequency and prognostic impact of microsatellite instability in a large population-based study of endometrial carcinomas.
Cancer research 2000;60(6):1750-2.
2000: Usha Menon; Ian J Jacobs
Recent developments in ovarian cancer screening.
Current opinion in obstetrics & gynecology 2000;12(1):39-42.
2000: Usha Menon; A Talaat; Adam N Rosenthal; Nicola D Macdonald; A R Jeyerajah; Steven J Skates; Karen Sibley; David H Oram; Ian J Jacobs
Performance of ultrasound as a second line test to serum CA125 in ovarian cancer screening.
BJOG : an international journal of obstetrics and gynaecology 2000;107(2):165-9.
2000: Ronald P Zweemer; Paulus van Diest; René H M Verheijen; A Ryan; Johan J P Gille; Rolf Sijmons; Ian J Jacobs; Fred H Menko; Peter Kenemans
Molecular evidence linking primary cancer of the fallopian tube to BRCA1 germline mutations.
Gynecologic oncology 2000;76(1):45-50.
1999: PD Peppercorn; Arjun Jeyarajah; Robert P Woolas; John H Shepherd; David H Oram; Ian J Jacobs; P Armstrong; D Lowe; Rodney H Reznek
Role of MR imaging in the selection of patients with early cervical carcinoma for fertility-preserving surgery: initial experience.
Radiology 1999;212(2):395-9.
1999: Usha Menon; A Talaat; Arjun Jeyarajah; Adam N Rosenthal; Nicola D Macdonald; Steven J Skates; Karen Sibley; David H Oram; Ian J Jacobs
Ultrasound assessment of ovarian cancer risk in postmenopausal women with CA125 elevation.
British journal of cancer 1999;80(10):1644-7.
1999: Ronald P Zweemer; Patricia A Shaw; R M Verheijen; A Ryan; Andrew Berchuck; bruce ponder; Harvey A Risch; John R McLaughlin; Steven A Narod; Fred H Menko; Peter Kenemans; Ian J Jacobs
Accumulation of p53 protein is frequent in ovarian cancers associated with BRCA1 and BRCA2 germline mutations.
Journal of clinical pathology 1999;52(5):372-5.
1999: Arjun Jeyarajah; T E J Ind; Nicola MacDonald; Steven J Skates; David H Oram; Ian J Jacobs
Increased mortality in postmenopausal women with serum CA125 elevation.
Gynecologic oncology 1999;73(2):242-6.
1999: Arjun Jeyarajah; T E J Ind; Steven J Skates; David H Oram; Ian J Jacobs
Serum CA125 elevation and risk of clinical detection of cancer in asymptomatic postmenopausal women.
Cancer 1999;85(9):2068-72.
1999: Estrid Hogdall; Claus K Hogdall; Susanne Krüger Kjaer; F Xu; Y Yu; R C Bast; Jan Blaakaer; Ian J Jacobs
OVX1 radioimmunoassay results are dependent on the method of sample collection and storage.
Clinical chemistry 1999;45(5):692-4.
1999: Ian J Jacobs; Steven J Skates; Nicola MacDonald; Usha Menon; Adam N Rosenthal; A P Davies; Robert P Woolas; Arjun Jeyarajah; Karen Sibley; David G Lowe; David H Oram
Screening for ovarian cancer: a pilot randomised controlled trial.
Lancet 1999;353(9160):1207-10.
1999: Nicola D Macdonald; Ian J Jacobs
Is there a place for screening in ovarian cancer?
European journal of obstetrics, gynecology, and reproductive biology 1999;82(2):155-7.
1999: Ronald P Zweemer; René H M Verheijen; Fred H Menko; Johan J P Gille; Paulus van Diest; J W Coebergh; Patricia A Shaw; Ian J Jacobs; Peter Kenemans
Differences between hereditary and sporadic ovarian cancer.
European journal of obstetrics, gynecology, and reproductive biology 1999;82(2):151-3.
1998: Adam N Rosenthal; Ian J Jacobs
The role of CA 125 in screening for ovarian cancer.
The International journal of biological markers 1998;13(4):216-20.
1998: Adam N Rosenthal; A Ryan; RM Al-Jehani; Alan Storey; Catherine A Harwood; Ian J Jacobs
p53 codon 72 polymorphism and risk of cervical cancer in UK.
Lancet 1998;352(9131):871-2.
1998: Nicola D Macdonald; Adam N Rosenthal; Ian J Jacobs
Screening for ovarian cancer.
Annals of the Academy of Medicine, Singapore 1998;27(5):676-82.
1998: RM Al-Jehani; Arjun Jeyarajah; B Hagen; Estrid Hogdall; David H Oram; Ian J Jacobs
Model for the molecular genetic diagnosis of endometrial cancer using K-ras mutation analysis.
Journal of the National Cancer Institute 1998;90(7):540-2.
1998: A Ryan; RM Al-Jehani; K T Mulligan; Ian J Jacobs
No evidence exists for methylation inactivation of the p16 tumor suppressor gene in ovarian carcinogenesis.
Gynecologic oncology 1998;68(1):14-7.
1996: Ian J Jacobs; Steven J Skates; A P Davies; Robert P Woolas; A Jeyerajah; P Weidemann; Karen Sibley; David H Oram
Risk of diagnosis of ovarian cancer after raised serum CA 125 concentration: a prospective cohort study.
BMJ (Clinical research ed.) 1996;313(7069):1355-8.
1995: J A Hurteau; Robert P Woolas; Ian J Jacobs; D C Oram; C C Kurman; L A Rubin; D L Nelson; Andrew Berchuck; Robert C Bast; G B Mills
Soluble interleukin-2 receptor alpha is elevated in sera of patients with benign ovarian neoplasms and epithelial ovarian cancer.
Cancer 1995;76(9):1615-20.
1995: Robert P Woolas; M R Conaway; F Xu; Ian J Jacobs; Y Yu; L Daly; A P Davies; KC O'Briant; Andrew Berchuck; John Soper
Combinations of multiple serum markers are superior to individual assays for discriminating malignant from benign pelvic masses.
Gynecologic oncology 1995;59(1):111-6.
1993: Ian J Jacobs; H Rivera; David H Oram; R C Bast
Differential diagnosis of ovarian cancer with tumour markers CA 125, CA 15-3 and TAG 72.3.
British journal of obstetrics and gynaecology 1993;100(12):1120-4.
1993: Robert P Woolas; FJ Xu; Ian J Jacobs; YH Yu; L Daly; Andrew Berchuck; John Soper; Daniel L Clarke-Pearson; David H Oram; Robert C Bast
Elevation of multiple serum markers in patients with stage I ovarian cancer.
Journal of the National Cancer Institute 1993;85(21):1748-51.
1993: Matthew F Kohler; Jeffrey R Marks; Roger W Wiseman; Ian J Jacobs; Andrew M Davidoff; Daniel L Clarke-Pearson; John Soper; Robert C Bast; Andrew Berchuck
Spectrum of mutation and frequency of allelic deletion of the p53 gene in ovarian cancer.
Journal of the National Cancer Institute 1993;85(18):1513-9.
1993: Ian J Jacobs; S A Smith; Roger W Wiseman; P Andrew Futreal; T Harrington; R J Osborne; Vanessa Leech; A Molyneux; Andrew Berchuck; Bruce A J Ponder
A deletion unit on chromosome 17q in epithelial ovarian tumors distal to the familial breast/ovarian cancer locus.
Cancer research 1993;53(6):1218-21.
1992: Ian J Jacobs; Matthew F Kohler; Roger W Wiseman; Jeffrey R Marks; R Whitaker; B A Kerns; P Humphrey; Andrew Berchuck; B A Ponder; Robert C Bast
Clonal origin of epithelial ovarian carcinoma: analysis by loss of heterozygosity, p53 mutation, and X-chromosome inactivation.
Journal of the National Cancer Institute 1992;84(23):1793-8.
1992: Ian J Jacobs; David H Oram; R C Bast
Strategies for improving the specificity of screening for ovarian cancer with tumor-associated antigens CA 125, CA 15-3, and TAG 72.3.
Obstetrics and gynecology 1992;80(3 Pt 1):396-9.
1990: David H Oram; Ian J Jacobs; J L Brady; A Prys-Davies
Early diagnosis of ovarian cancer.
British journal of hospital medicine 1990;44(5):320, 322, 324.
1990: T N Fay; Ian J Jacobs; Børge Teisner; Jes G Westergaard; J Gedis Grudzinskas
A biochemical test for the direct assessment of endometrial function: measurement of the major secretory endometrial protein PP14 in serum during menstruation in relation to ovulation and luteal function.
Human reproduction (Oxford, England) 1990;5(4):382-6.
1990: Ian J Jacobs; T N Fay; J Yovich; I Stabile; C Frost; J Turner; David H Oram; J Gedis Grudzinskas
Serum levels of CA 125 during the first trimester of normal outcome, ectopic and anembryonic pregnancies.
Human reproduction (Oxford, England) 1990;5(1):116-22.
1988: Ian J Jacobs; T N Fay; I Stabile; J E Bridges; David H Oram; J Gedis Grudzinskas
The distribution of CA 125 in the reproductive tract of pregnant and non-pregnant women.
British journal of obstetrics and gynaecology 1988;95(11):1190-4.