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René Jacobs

Research Profile

Chemicals & Drugs

Anatomy

Living Beings

Phenomena

Methylation

Disorders

Fatty Liver

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Publications

TOP 3
Bruce Erickson; René L Jacobs; Karen Kelly; Kirst King-Jones; Kerry W S Ko; Lena Li; Randy Nelson; Ariel D Quiroga; Senthamil Paramadayalan Selvan; Richard Lehner
Endoplasmic reticulum-localized hepatic lipase decreases triacylglycerol storage and VLDL secretion.
Gengshu Wu; Liyan Zhang; Azeret Zuniga; René L Jacobs; Liang Li; Tete Li; Gary D Lopaschuk; Dennis E Vance
Choline supplementation promotes hepatic insulin resistance in phosphatidylethanolamine N-methyltransferase-deficient mice via increased glucagon action.
Yeping Xiong; Yuan-Yuan Zhao; Catherine J Field; Sue Goruk; René L Jacobs; Kirsten Oilund; Jonathan M Curtis
Validation of an LC-MS/MS method for the quantification of choline-related compounds and phospholipids in foods and tissues.

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2013: Bruce Erickson; René L Jacobs; Karen Kelly; Kirst King-Jones; Kerry W S Ko; Lena Li; Randy Nelson; Ariel D Quiroga; Senthamil Paramadayalan Selvan; Richard Lehner
Endoplasmic reticulum-localized hepatic lipase decreases triacylglycerol storage and VLDL secretion.
Biochimica et biophysica acta 2013;1831(6):1113-23.
2013: Gengshu Wu; Liyan Zhang; Azeret Zuniga; René L Jacobs; Liang Li; Tete Li; Gary D Lopaschuk; Dennis E Vance
Choline supplementation promotes hepatic insulin resistance in phosphatidylethanolamine N-methyltransferase-deficient mice via increased glucagon action.
The Journal of biological chemistry 2013;288(2):837-47.
2012: Yeping Xiong; Yuan-Yuan Zhao; Catherine J Field; Sue Goruk; René L Jacobs; Kirsten Oilund; Jonathan M Curtis
Validation of an LC-MS/MS method for the quantification of choline-related compounds and phospholipids in foods and tissues.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2012;911():170-9.
2012: Ji Ling; Dennis E Vance; Lin Fu Zhu; René L Jacobs
Impaired phosphatidylcholine biosynthesis does not attenuate liver regeneration after 70% partial hepatectomy in hepatic CTP:phosphocholine cytidylyltransferase-α deficient mice.
Canadian journal of physiology and pharmacology 2012;90(10):1403-12.
2012: Ji Ling; Todd Chaba; René L Jacobs; Lin-Fu Zhu; Dennis E Vance
Hepatic ratio of phosphatidylcholine to phosphatidylethanolamine predicts survival after partial hepatectomy in mice.
Hepatology (Baltimore, Md.) 2012;55(4):1094-102.
2012: Gengshu Wu; Liyan Zhang; Tete Li; Gary Lopaschuk; Dennis E Vance; René L Jacobs
Choline Deficiency Attenuates Body Weight Gain and Improves Glucose Tolerance in ob/ob Mice.
Journal of obesity 2012;2012():319172.
2011: Lorissa J Niebergall; Todd Chaba; René L Jacobs; Dennis E Vance
Phosphatidylcholine protects against steatosis in mice but not non-alcoholic steatohepatitis.
Biochimica et biophysica acta 2011;1811(12):1177-85.
2011: Rafael Deminice; George N Furey; René L Jacobs; Alceu Afonso Jordao; Karen B Kelly; Kirst King-Jones; Simon G. Lamarre; Shannon A McCarter; Margaret E Brosnan; Colin Brown; Robin P da Silva; John T Brosnan
Creatine supplementation prevents the accumulation of fat in the livers of rats fed a high-fat diet.
The Journal of nutrition 2011;141(10):1799-804.
2011: Miranda M Y Sung; Debby P Y Koonen; Carrie-Lynn M Soltys; René L Jacobs; Maria Febbraio; Jason R B Dyck
Increased CD36 expression in middle-aged mice contributes to obesity-related cardiac hypertrophy in the absence of cardiac dysfunction.
Journal of molecular medicine (Berlin, Germany) 2011;89(5):459-69.
2010: Laura K Cole; René L Jacobs; Dennis E Vance
Tamoxifen induces triacylglycerol accumulation in the mouse liver by activation of fatty acid synthesis.
Hepatology (Baltimore, Md.) 2010;52(4):1258-65.
2010: René L Jacobs; Yang Zhao; Debby P Y Koonen; Torunn Sletten; Brian Su; Susanne Lingrell; Guoqing Cao; David A Peake; Ming-Shang Kuo; Spencer D Proctor; Brian P Kennedy; Jason R B Dyck; Dennis E Vance
Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity.
The Journal of biological chemistry 2010;285(29):22403-13.
2010: Debby P Y Koonen; Miranda M Y Sung; Cindy K C Kao; Vernon W Dolinsky; Timothy R Koves; Olga Ilkayeva; René L Jacobs; Dennis E Vance; Peter E Light; Deborah M Muoio; Maria Febbraio; Jason R B Dyck
Alterations in skeletal muscle fatty acid handling predisposes middle-aged mice to diet-induced insulin resistance.
Diabetes 2010;59(6):1366-75.
2009: Yang Zhao; Brian Su; René L Jacobs; Brian Kennedy; Gordon A Francis; Emma Waddington; John T Brosnan; Jean E Vance; Dennis E Vance
Lack of phosphatidylethanolamine N-methyltransferase alters plasma VLDL phospholipids and attenuates atherosclerosis in mice.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(9):1349-55.
2008: René L Jacobs; Susanne Lingrell; Yang Zhao; Gordon A Francis; Dennis E Vance
Hepatic CTP:phosphocholine cytidylyltransferase-alpha is a critical predictor of plasma high density lipoprotein and very low density lipoprotein.
The Journal of biological chemistry 2008;283(4):2147-55.
2007: Debby P Y Koonen; René L Jacobs; Maria Febbraio; Martin E Young; Carrie-Lynn M Soltys; Huy Ong; Dennis E Vance; Jason R B Dyck
Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity.
Diabetes 2007;56(12):2863-71.
2007: Dennis E Vance; Zhaoyu Li; René L Jacobs
Hepatic phosphatidylethanolamine N-methyltransferase, unexpected roles in animal biochemistry and physiology.
The Journal of biological chemistry 2007;282(46):33237-41.
2007: René L Jacobs; Susanne Lingrell; Jason R B Dyck; Dennis E Vance
Inhibition of hepatic phosphatidylcholine synthesis by 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside is independent of AMP-activated protein kinase activation.
The Journal of biological chemistry 2007;282(7):4516-23.
2007: S Harvey Mudd; John T Brosnan; Margaret E Brosnan; René L Jacobs; Sally P Stabler; Robert H Allen; Dennis E Vance; Conrad Wagner
Methyl balance and transmethylation fluxes in humans.
The American journal of clinical nutrition 2007;85(1):19-25.
2006: Lori M Stead; John T Brosnan; Margaret E Brosnan; Dennis E Vance; René L Jacobs
Is it time to reevaluate methyl balance in humans?
The American journal of clinical nutrition 2006;83(1):5-10.
2005: René L Jacobs; Lori M Stead; Cecilia Devlin; Ira Tabas; Margaret E Brosnan; John T Brosnan; Dennis E Vance
Physiological regulation of phospholipid methylation alters plasma homocysteine in mice.
The Journal of biological chemistry 2005;280(31):28299-305.
2004: René L Jacobs; Cecilia Devlin; Ira Tabas; Dennis E Vance
Targeted deletion of hepatic CTP:phosphocholine cytidylyltransferase alpha in mice decreases plasma high density and very low density lipoproteins.
The Journal of biological chemistry 2004;279(45):47402-10.
2004: Lori M Stead; René L Jacobs; Margaret E Brosnan; John T Brosnan
Methylation demand and homocysteine metabolism.
Advances in enzyme regulation 2004;44():321-33.
2004: John T Brosnan; René L Jacobs; Lori M Stead; Margaret E Brosnan
Methylation demand: a key determinant of homocysteine metabolism.
Acta biochimica Polonica 2004;51(2):405-13.
2002: Shobhitha Ratnam; Kenneth N Maclean; René L Jacobs; Margaret E Brosnan; Jan P Kraus; John T Brosnan
Hormonal regulation of cystathionine beta-synthase expression in liver.
The Journal of biological chemistry 2002;277(45):42912-8.
2001: René L Jacobs; Lori M Stead; Margaret E Brosnan; John T Brosnan
Hyperglucagonemia in rats results in decreased plasma homocysteine and increased flux through the transsulfuration pathway in liver.
The Journal of biological chemistry 2001;276(47):43740-7.
2001: Lori M Stead; K P Au; René L Jacobs; Margaret E Brosnan; John T Brosnan
Methylation demand and homocysteine metabolism: effects of dietary provision of creatine and guanidinoacetate.
American journal of physiology. Endocrinology and metabolism 2001;281(5):E1095-100.
2000: René L Jacobs; Lori M Stead; Margaret E Brosnan; John T Brosnan
Plasma homocysteine is decreased in the hypothyroid rat.
Canadian journal of physiology and pharmacology 2000;78(7):565-70.
1999: James House; René L Jacobs; Lori M Stead; Margaret E Brosnan; John T Brosnan
Regulation of homocysteine metabolism.
Advances in enzyme regulation 1999;39():69-91.
1998: René L Jacobs; James House; Margaret E Brosnan; John T Brosnan
Effects of streptozotocin-induced diabetes and of insulin treatment on homocysteine metabolism in the rat.
Diabetes 1998;47(12):1967-70.