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Christian Jacobsen
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31
Moestrup, Søren
16
Christensen, Erik
16
Willnow, Thomas
10
Verroust, Pierre
10
Petersen, Claus
10
Nykjaer, Anders
9
Nielsen, Morten
9
Gliemann, Jørgen
7
Etzerodt, Michael
7
Madsen, Peder
7
Graversen, Jonas
6
Vorum, Henrik
5
Thøgersen, Hans
5
Kozyraki, Renata
5
Kristiansen, M
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All Publications
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2009: Hansen Gry Aune Westergaard; Vorum Henrik; Jacobsen Christian; Honoré Bent
Calumenin but not reticulocalbin forms a Ca2+-dependent complex with thrombospondin-1. A potential role in haemostasis and thrombosis.
Molecular and cellular biochemistry 2009;320(1-2):25-33.
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2008: Stapulionis Romualdas; Oliveira Cristiano Luis Pinto; Gjelstrup Mikkel Carstensen; Pedersen Jan Skov; Hokland Marianne Elisabet; Hoffmann Søren Vrønning; Poulsen Knud; Jacobsen Christian; Vorup-Jensen Thomas
Structural insight into the function of myelin basic protein as a ligand for integrin alpha M beta 2.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(6):3946-56.
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2007: Nielsen Rikke; Courtoy Pierre J; Jacobsen Christian; Dom Geneviève; Lima Wânia Rezende; Jadot Michel; Willnow Thomas E; Devuyst Olivier; Christensen Erik I
Endocytosis provides a major alternative pathway for lysosomal biogenesis in kidney proximal tubular cells.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(13):5407-12.
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2007: Christensen Erik I; Zhou Qun; Sørensen Søren S; Rasmussen Ase K; Jacobsen Christian; Feldt-Rasmussen Ulla; Nielsen Rikke
Distribution of alpha-galactosidase A in normal human kidney and renal accumulation and distribution of recombinant alpha-galactosidase A in Fabry mice.
Journal of the American Society of Nephrology : JASN 2007;18(3):698-706.
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2007: Nielsen Marianne Jensby; Petersen Steen Vang; Jacobsen Christian; Thirup Søren; Enghild Jan Johannes; Graversen Jonas Heilskov; Moestrup Søren Kragh
A unique loop extension in the serine protease domain of haptoglobin is essential for CD163 recognition of the haptoglobin-hemoglobin complex.
The Journal of biological chemistry 2007;282(2):1072-9.
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2006: Nielsen Marianne Jensby; Petersen Steen Vang; Jacobsen Christian; Oxvig Claus; Rees David; Møller Holger Jon; Moestrup Søren Kragh
Haptoglobin-related protein is a high-affinity hemoglobin-binding plasma protein.
Blood 2006;108(8):2846-9.
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2006: Van den Steen Philippe E; Van Aelst Ilse; Hvidberg Vibeke; Piccard Helene; Fiten Pierre; Jacobsen Christian; Moestrup Soren K; Fry Simon; Royle Louise; Wormald Mark R; Wallis Russell; Rudd Pauline M; Dwek Raymond A; Opdenakker Ghislain
The hemopexin and O-glycosylated domains tune gelatinase B/MMP-9 bioavailability via inhibition and binding to cargo receptors.
The Journal of biological chemistry 2006;281(27):18626-37.
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2006: Sanggaard Kristian W; Sonne-Schmidt Carsten S; Jacobsen Christian; Thøgersen Ida B; Valnickova Zuzana; Wisniewski Hans-Georg; Enghild Jan J
Evidence for a two-step mechanism involved in the formation of covalent HC x TSG-6 complexes.
Biochemistry 2006;45(24):7661-8.
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2005: Hvidberg Vibeke; Maniecki Maciej B; Jacobsen Christian; Højrup Peter; Møller Holger J; Moestrup Søren K
Identification of the receptor scavenging hemopexin-heme complexes.
Blood 2005;106(7):2572-9.
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2005: Birn Henrik; Zhai Xiaoyue; Holm Jan; Hansen Steen I; Jacobsen Christian; Christensen Erik I; Moestrup Søren K
Megalin binds and mediates cellular internalization of folate binding protein.
The FEBS journal 2005;272(17):4423-30.
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2005: Westergaard U B; Kirkegaard K; Sørensen E S; Jacobsen C; Nielsen M S; Petersen C M; Madsen P
SorCS3 does not require propeptide cleavage to bind nerve growth factor.
FEBS letters 2005;579(5):1172-6.
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2005: Hvidberg Vibeke; Jacobsen Christian; Strong Roland K; Cowland Jack B; Moestrup Søren K; Borregaard Niels
The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake.
FEBS letters 2005;579(3):773-7.
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2004: Madsen Mette; Møller Holger J; Nielsen Marianne Jensby; Jacobsen Christian; Graversen Jonas H; van den Berg Timo; Moestrup Søren K
Molecular characterization of the haptoglobin.hemoglobin receptor CD163. Ligand binding properties of the scavenger receptor cysteine-rich domain region.
The Journal of biological chemistry 2004;279(49):51561-7.
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2004: Westergaard Uffe B; Sørensen Esben S; Hermey Guido; Nielsen Morten S; Nykjaer Anders; Kirkegaard Kirstine; Jacobsen Christian; Gliemann Jørgen; Madsen Peder; Petersen Claus Munck
Functional organization of the sortilin Vps10p domain.
The Journal of biological chemistry 2004;279(48):50221-9.
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2004: Gliemann Jørgen; Hermey Guido; Nykjaer Anders; Petersen Claus M; Jacobsen Christian; Andreasen Peter A
The mosaic receptor sorLA/LR11 binds components of the plasminogen-activating system and platelet-derived growth factor-BB similarly to LRP1 (low-density lipoprotein receptor-related protein), but mediates slow internalization of bound ligand.
The Biochemical journal 2004;381(Pt 1):203-12.
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2004: Petersen Helle Heibroch; Hilpert Jan; Jacobsen Christian; Lauwers Annick; Roebroek Anton J M; Willnow Thomas E
Low-density lipoprotein receptor-related protein interacts with MafB, a regulator of hindbrain development.
FEBS letters 2004;565(1-3):23-7.
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2004: Petersen Steen V; Oury Tim D; Ostergaard Louise; Valnickova Zuzana; Wegrzyn Joanna; Thøgersen Ida B; Jacobsen Christian; Bowler Russell P; Fattman Cheryl L; Crapo James D; Enghild Jan J
Extracellular superoxide dismutase (EC-SOD) binds to type i collagen and protects against oxidative fragmentation.
The Journal of biological chemistry 2004;279(14):13705-10.
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2004: Nykjaer Anders; Lee Ramee; Teng Kenneth K; Jansen Pernille; Madsen Peder; Nielsen Morten S; Jacobsen Christian; Kliemannel Marco; Schwarz Elisabeth; Willnow Thomas E; Hempstead Barbara L; Petersen Claus M
Sortilin is essential for proNGF-induced neuronal cell death.
Nature 2004;427(6977):843-8.
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2003: Horn Ivo R; Nielsen Marianne Jensby; Madsen Mette; Jacobsen Christian; Graversen Jonas Heilskov; Moestrup Søren K
Generation of a haptoglobin-hemoglobin complex-specific Fab antibody blocking the binding of the complex to CD163.
European journal of haematology 2003;71(4):289-93.
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2003: Gburek Jakub; Birn Henrik; Verroust Pierre J; Goj Boguslawa; Jacobsen Christian; Moestrup Søren K; Willnow Thomas E; Christensen Erik I
Renal uptake of myoglobin is mediated by the endocytic receptors megalin and cubilin.
American journal of physiology. Renal physiology 2003;285(3):F451-8.
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2003: Conticello Silvestro G; Kowalsman Noga D; Jacobsen Christian; Yudkovsky Guennady; Sato Kazuki; Elazar Zvulun; Petersen Claus Munck; Aronheim Ami; Fainzilber Mike
The prodomain of a secreted hydrophobic mini-protein facilitates its export from the endoplasmic reticulum by hitchhiking on sorting receptors.
The Journal of biological chemistry 2003;278(29):26311-4.
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2003: Petersen Helle Heibroch; Hilpert Jan; Militz Daniel; Zandler Valerie; Jacobsen Christian; Roebroek Anton J M; Willnow Thomas E
Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule.
Journal of cell science 2003;116(Pt 3):453-61.
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2003: Hermey Guido; Keat Sady J; Madsen Peder; Jacobsen Christian; Petersen Claus M; Gliemann Jorgen
Characterization of sorCS1, an alternatively spliced receptor with completely different cytoplasmic domains that mediate different trafficking in cells.
The Journal of biological chemistry 2003;278(9):7390-6.
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2002: Caterer Nigel R; Graversen Jonas H; Jacobsen Christian; Moestrup Søren K; Sigurskjold Bent W; Etzerodt Michael; Thøgersen Hans C
Specificity determinants in the interaction of apolipoprotein(a) kringles with tetranectin and LDL.
Biological chemistry 2002;383(11):1743-50.
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2002: Gburek Jakub; Verroust Pierre J; Willnow Thomas E; Fyfe John C; Nowacki Wojciech; Jacobsen Christian; Moestrup Søren K; Christensen Erik I
Megalin and cubilin are endocytic receptors involved in renal clearance of hemoglobin.
Journal of the American Society of Nephrology : JASN 2002;13(2):423-30.
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2002: Schmitz Christian; Hilpert Jan; Jacobsen Christian; Boensch Christian; Christensen Erik Ilsø; Luft Friedrich C; Willnow Thomas E
Megalin deficiency offers protection from renal aminoglycoside accumulation.
The Journal of biological chemistry 2002;277(1):618-22.
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2001: Andersen O M; Schwarz F P; Eisenstein E; Jacobsen C; Moestrup S K; Etzerodt M; Thøgersen H C
Dominant thermodynamic role of the third independent receptor binding site in the receptor-associated protein RAP.
Biochemistry 2001;40(50):15408-17.
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2001: Nykjaer A; Fyfe J C; Kozyraki R; Leheste J R; Jacobsen C; Nielsen M S; Verroust P J; Aminoff M; de la Chapelle A; Moestrup S K; Ray R; Gliemann J; Willnow T E; Christensen E I
Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3).
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13895-900.
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2001: Kozyraki R; Fyfe J; Verroust P J; Jacobsen C; Dautry-Varsat A; Gburek J; Willnow T E; Christensen E I; Moestrup S K
Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(22):12491-6.
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2001: Andersen O M; Petersen H H; Jacobsen C; Moestrup S K; Etzerodt M; Andreasen P A; Thøgersen H C
Analysis of a two-domain binding site for the urokinase-type plasminogen activator-plasminogen activator inhibitor-1 complex in low-density-lipoprotein-receptor-related protein.
The Biochemical journal 2001;357(Pt 1):289-96.
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2001: Jacobsen L; Madsen P; Jacobsen C; Nielsen M S; Gliemann J; Petersen C M
Activation and functional characterization of the mosaic receptor SorLA/LR11.
The Journal of biological chemistry 2001;276(25):22788-96.
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2001: Burmeister R; Boe I M; Nykjaer A; Jacobsen C; Moestrup S K; Verroust P; Christensen E I; Lund J; Willnow T E
A two-receptor pathway for catabolism of Clara cell secretory protein in the kidney.
The Journal of biological chemistry 2001;276(16):13295-301.
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2001: Kristiansen M; Graversen J H; Jacobsen C; Sonne O; Hoffman H J; Law S K; Moestrup S K
Identification of the haemoglobin scavenger receptor.
Nature 2001;409(6817):198-201.
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2000: Graversen J H; Jacobsen C; Sigurskjold B W; Lorentsen R H; Moestrup S K; Thogersen H C; Etzerodt M
Mutational analysis of affinity and selectivity of kringle-tetranectin interaction. Grafting novel kringle affinity ontp the trtranectin lectin scaffold.
The Journal of biological chemistry 2000;275(48):37390-6.
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2000: Andersen O M; Christensen P A; Christensen L L; Jacobsen C; Moestrup S K; Etzerodt M; Thogersen H C
Specific binding of alpha-macroglobulin to complement-type repeat CR4 of the low-density lipoprotein receptor-related protein.
Biochemistry 2000;39(35):10627-33.
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2000: Kristiansen M; Aminoff M; Jacobsen C; de La Chapelle A; Krahe R; Verroust P J; Moestrup S K
Cubilin P1297L mutation associated with hereditary megaloblastic anemia 1 causes impaired recognition of intrinsic factor-vitamin B(12) by cubilin.
Blood 2000;96(2):405-9.
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2000: Andersen O M; Christensen L L; Christensen P A; Sørensen E S; Jacobsen C; Moestrup S K; Etzerodt M; Thogersen H C
Identification of the minimal functional unit in the low density lipoprotein receptor-related protein for binding the receptor-associated protein (RAP). A conserved acidic residue in the complement-type repeats is important for recognition of RAP.
The Journal of biological chemistry 2000;275(28):21017-24.
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2000: Birn H; Fyfe J C; Jacobsen C; Mounier F; Verroust P J; Orskov H; Willnow T E; Moestrup S K; Christensen E I
Cubilin is an albumin binding protein important for renal tubular albumin reabsorption.
The Journal of clinical investigation 2000;105(10):1353-61.
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2000: Vorum H; Jacobsen C; Honoré B
Calumenin interacts with serum amyloid P component.
FEBS letters 2000;465(2-3):129-34.
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1999: Leheste J R; Rolinski B; Vorum H; Hilpert J; Nykjaer A; Jacobsen C; Aucouturier P; Moskaug J O; Otto A; Christensen E I; Willnow T E
Megalin knockout mice as an animal model of low molecular weight proteinuria.
The American journal of pathology 1999;155(4):1361-70.
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1999: Kristiansen M; Kozyraki R; Jacobsen C; Nexø E; Verroust P J; Moestrup S K
Molecular dissection of the intrinsic factor-vitamin B12 receptor, cubilin, discloses regions important for membrane association and ligand binding.
The Journal of biological chemistry 1999;274(29):20540-4.
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1999: Kozyraki R; Fyfe J; Kristiansen M; Gerdes C; Jacobsen C; Cui S; Christensen E I; Aminoff M; de la Chapelle A; Krahe R; Verroust P J; Moestrup S K
The intrinsic factor-vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein.
Nature medicine 1999;5(6):656-61.
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1999: Christensen E I; Moskaug J O; Vorum H; Jacobsen C; Gundersen T E; Nykjaer A; Blomhoff R; Willnow T E; Moestrup S K
Evidence for an essential role of megalin in transepithelial transport of retinol.
Journal of the American Society of Nephrology : JASN 1999;10(4):685-95.
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1999: Nielsen M S; Jacobsen C; Olivecrona G; Gliemann J; Petersen C M
Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase.
The Journal of biological chemistry 1999;274(13):8832-6.
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1999: Nykjaer A; Dragun D; Walther D; Vorum H; Jacobsen C; Herz J; Melsen F; Christensen E I; Willnow T E
An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3.
Cell 1999;96(4):507-15.
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1999: Hilpert J; Nykjaer A; Jacobsen C; Wallukat G; Nielsen R; Moestrup S K; Haller H; Luft F C; Christensen E I; Willnow T E
Megalin antagonizes activation of the parathyroid hormone receptor.
The Journal of biological chemistry 1999;274(9):5620-5.
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1999: Munck Petersen C; Nielsen M S; Jacobsen C; Tauris J; Jacobsen L; Gliemann J; Moestrup S K; Madsen P
Propeptide cleavage conditions sortilin/neurotensin receptor-3 for ligand binding.
The EMBO journal 1999;18(3):595-604.
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1998: Graversen J H; Lorentsen R H; Jacobsen C; Moestrup S K; Sigurskjold B W; Thogersen H C; Etzerodt M
The plasminogen binding site of the C-type lectin tetranectin is located in the carbohydrate recognition domain, and binding is sensitive to both calcium and lysine.
The Journal of biological chemistry 1998;273(44):29241-6.
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1998: Moestrup S K; Schousboe I; Jacobsen C; Leheste J R; Christensen E I; Willnow T E
beta2-glycoprotein-I (apolipoprotein H) and beta2-glycoprotein-I-phospholipid complex harbor a recognition site for the endocytic receptor megalin.
The Journal of clinical investigation 1998;102(5):902-9.
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1998: Tauris J; Ellgaard L; Jacobsen C; Nielsen M S; Madsen P; Thøgersen H C; Gliemann J; Petersen C M; Moestrup S K
The carboxy-terminal domain of the receptor-associated protein binds to the Vps10p domain of sortilin.
FEBS letters 1998;429(1):27-30.
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1998: Kozyraki R; Kristiansen M; Silahtaroglu A; Hansen C; Jacobsen C; Tommerup N; Verroust P J; Moestrup S K
The human intrinsic factor-vitamin B12 receptor, cubilin: molecular characterization and chromosomal mapping of the gene to 10p within the autosomal recessive megaloblastic anemia (MGA1) region.
Blood 1998;91(10):3593-600.
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1998: Hartmann R; Norby P L; Martensen P M; Jorgensen P; James M C; Jacobsen C; Moestrup S K; Clemens M J; Justesen J
Activation of 2'-5' oligoadenylate synthetase by single-stranded and double-stranded RNA aptamers.
The Journal of biological chemistry 1998;273(6):3236-46.
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1997: Jessen H; Jacobsen C
Adaptive regulation of taurine and beta-alanine uptake in a human kidney cell line from the proximal tubule.
Biochimica et biophysica acta 1997;1325(2):309-17.
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1996: Petersen C M; Ellgaard L; Nykjaer A; Vilhardt F; Vorum H; Thøgersen H C; Nielsen M S; Jacobsen C; Moestrup S K; Gliemann J
The receptor-associated protein (RAP) binds calmodulin and is phosphorylated by calmodulin-dependent kinase II.
The EMBO journal 1996;15(16):4165-73.
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1996: Jessen H; Røigaard H; Jacobsen C
Uptake of neutral alpha- and beta-amino acids by human proximal tubular cells.
Biochimica et biophysica acta 1996;1282(2):225-32.
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1995: Jacobsen C; Jessen H; Flyvbjerg A
IGF-II receptors in luminal and basolateral membranes isolated from pars convoluta and pars recta of rabbit proximal tubule.
Biochimica et biophysica acta 1995;1235(1):85-92.
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1994: Jessen H; Røigaard H; Riahi-Esfahani S; Jacobsen C
A comparative study on the uptake of alpha-aminoisobutyric acid by normal and immortalized human embryonic kidney cells from proximal tubule.
Biochimica et biophysica acta 1994;1190(2):279-88.
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1993: Flyvbjerg A; Nielsen S; Sheikh M I; Jacobsen C; Orskov H; Christensen E I
Luminal and basolateral uptake and receptor binding of IGF-I in rabbit renal proximal tubules.
The American journal of physiology 1993;265(5 Pt 2):F624-33.
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1992: Buhl A M; Sheikh M I; Steensgaard J; Røigaard-Petersen H; Jacobsen C
GTP-binding proteins in luminal and basolateral membranes from pars convoluta and pars recta of rabbit kidney proximal tubule.
FEBS letters 1992;304(2-3):179-83.
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1991: Blokkebak-Poulsen J; Sheikh M I; Jacobsen C
Effects of divalent cations and pH on amiloride-sensitive Na+ fluxes into luminal membrane vesicles from pars recta of rabbit proximal tubule.
Biochimica et biophysica acta 1991;1068(2):125-32.
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1990: Blokkebak-Poulsen J; Sheikh M I; Jacobsen C
Non-selective cation channels in basolateral-membrane vesicles from pars recta of rabbit kidney proximal tubule.
The Biochemical journal 1990;272(3):839-42.
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1990: Jacobsen C; Blokkebak-Poulsen J; Sheikh M I
Potassium channels in basolateral membrane vesicles from pars convoluta of rabbit proximal tubule.
FEBS letters 1990;269(2):315-8.
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1990: Jacobsen C; Mollerup S; Sheikh M I
Ca2+ and pH regulation of K+ channels in membrane vesicles of rabbit proximal tubule.
The American journal of physiology 1990;258(6 Pt 2):F1634-9.
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1990: Røigaard-Petersen H; Jessen H; Mollerup S; Jørgensen K E; Jacobsen C; Sheikh M I
Proton gradient-dependent renal transport of glycine: evidence for vesicle studies.
The American journal of physiology 1990;258(2 Pt 2):F388-96.
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1989: Røigaard-Petersen H; Jacobsen C; Jessen H; Mollerup S; Sheikh M I
Electrogenic uptake of D-imino acids by luminal membrane vesicles from rabbit kidney proximal tubule.
Biochimica et biophysica acta 1989;984(2):231-7.
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1989: Jacobsen C; Røigaard-Petersen H; Sheikh M I
Potassium channels in the luminal membrane of rabbit proximal straight tubule. Evidence from vesicle studies.
The Biochemical journal 1989;262(1):271-5.
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1989: Jacobsen C; Røigaard-Petersen H; Sheikh M I
Ba2+-sensitive K+ channels in luminal-membrane vesicles from pars convoluta of rabbit proximal tubule.
FEBS letters 1989;243(2):173-6.
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1988: Jacobsen C; Røigaard-Petersen H; Sheikh M I
Demonstration of Na+-selective channels in the luminal-membrane vesicles isolated from pars recta of rabbit proximal tubule.
FEBS letters 1988;236(1):95-9.
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1988: Røigaard-Petersen H; Jacobsen C; Sheikh M I
Transport of L-proline by luminal membrane vesicles from pars recta of rabbit proximal tubule.
The American journal of physiology 1988;254(5 Pt 2):F628-33.
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1987: Røigaard-Petersen H; Jacobsen C; Iqbal Sheikh M
H+-L-proline cotransport by vesicles from pars convoluta of rabbit proximal tubule.
The American journal of physiology 1987;253(1 Pt 2):F15-20.
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1986: Jacobsen C; Kragh-Hansen U; Sheikh M I
Na+-H+ exchange in luminal-membrane vesicles from rabbit proximal convoluted and straight tubules in response to metabolic acidosis.
The Biochemical journal 1986;239(2):411-6.
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1986: Røigaard-Petersen H; Jacobsen C; Sheikh M I
Characteristics of D-galactose transport systems by luminal membrane vesicles from rabbit kidney.
Biochimica et biophysica acta 1986;856(3):578-84.
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1984: Jacobsen C; Røigaard-Petersen H; Jørgensen K E; Sheikh M I
Isolation and partial purification of dicarboxylic acid binding protein from luminal-membrane vesicles of rabbit kidney cortex.
Biochimica et biophysica acta 1984;773(1):173-9.
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1984: Kragh-Hansen U; Røigaard-Petersen H; Jacobsen C; Sheikh M I
Renal transport of neutral amino acids. Tubular localization of Na+-dependent phenylalanine- and glucose-transport systems.
The Biochemical journal 1984;220(1):15-24.
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