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Peer Jacobson

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Sarah Malek; Jason A Bleedorn; Elizabeth M Cozzi; Gerianne Holzman; Peer B Jacobson; Brett Nemke; Susannah J Sample; Susan L Schaefer; Zeev Schwartz; Peter Muir
Effect of analgesic therapy on clinical outcome measures in a randomized controlled trial using client-owned dogs with hip osteoarthritis.
Chang Z Zhu; Scott Baker; Jordan Brown; Prasant Chandran; Chih-Liang Chin; Michael W Decker; Gerard B Fox; Donna Gauvin; Erica Gomez; Murali Gopalakrishnan; Peer B Jacobson; Victoria A Komater; Chih-Hung Lee; La Geisha Lewis; Joe Mikusa; Madhavi Pai; Nathan R Rustay; Anita Salyers; Gricelda Simler; A Tovcimak; Chengmin Zhong; Prisca Honore
Potentiation of analgesic efficacy but not side effects: co-administration of an α4β2 neuronal nicotinic acetylcholine receptor agonist and its positive allosteric modulator in experimental models of pain in rats.
Eric G Mohler; Kaitlin E Browman; Victoria A Roderwald; Elizabeth A Cronin; Stella Markosyan; R Scott Bitner; Marina I Strakhova; Karla U Drescher; Wilfried Hornberger; Jeffrey J Rohde; Michael E Brune; Peer B Jacobson; Lynne E Rueter
Acute inhibition of 11beta-hydroxysteroid dehydrogenase type-1 improves memory in rodent models of cognition.

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All Publications

2012: Sarah Malek; Jason A Bleedorn; Elizabeth M Cozzi; Gerianne Holzman; Peer B Jacobson; Brett Nemke; Susannah J Sample; Susan L Schaefer; Zeev Schwartz; Peter Muir
Effect of analgesic therapy on clinical outcome measures in a randomized controlled trial using client-owned dogs with hip osteoarthritis.
BMC veterinary research 2012;8():185.
2011: Chang Z Zhu; Scott Baker; Jordan Brown; Prasant Chandran; Chih-Liang Chin; Michael W Decker; Gerard B Fox; Donna Gauvin; Erica Gomez; Murali Gopalakrishnan; Peer B Jacobson; Victoria A Komater; Chih-Hung Lee; La Geisha Lewis; Joe Mikusa; Madhavi Pai; Nathan R Rustay; Anita Salyers; Gricelda Simler; A Tovcimak; Chengmin Zhong; Prisca Honore
Potentiation of analgesic efficacy but not side effects: co-administration of an α4β2 neuronal nicotinic acetylcholine receptor agonist and its positive allosteric modulator in experimental models of pain in rats.
Biochemical pharmacology 2011;82(8):967-76.
2011: Eric G Mohler; Kaitlin E Browman; Victoria A Roderwald; Elizabeth A Cronin; Stella Markosyan; R Scott Bitner; Marina I Strakhova; Karla U Drescher; Wilfried Hornberger; Jeffrey J Rohde; Michael E Brune; Peer B Jacobson; Lynne E Rueter
Acute inhibition of 11beta-hydroxysteroid dehydrogenase type-1 improves memory in rodent models of cognition.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(14):5406-13.
2007: Ruojing Yang; Denise M Wilcox; Deanna L Haasch; Paul Martin Jung; Phong T Nguyen; Martin J Voorbach; Stella Z Doktor; Sevan Brodjian; Eugene N Bush; Emily Lin; Peer B Jacobson; Christine A Collins; Katherine Landschulz; James M Trevillyan; cristina Rondinone; Teresa K Surowy
Liver-specific knockdown of JNK1 up-regulates proliferator-activated receptor gamma coactivator 1 beta and increases plasma triglyceride despite reduced glucose and insulin levels in diet-induced obese mice.
The Journal of biological chemistry 2007;282(31):22765-74.
2007: Jeffrey J Rohde; Marina Pliushchev; Bryan K Sorensen; Dariusz Wodka; Qi Shuai; Jiahong Wang; Steven Fung; Katina Monzon; William J Chiou; Liping Pan; Xiaoqing Deng; Linda E Chovan; Atul Ramaiya; Mark Mullally; Rodger F Henry; Deanne Stolarik; Hovis Imade; Kennan Marsh; David W A Beno; Thomas A Fey; Brian A Droz; Michael E Brune; Heidi S Camp; Hing L Sham; Ernst U Frevert; Peer B Jacobson; James T Link
Discovery and metabolic stabilization of potent and selective 2-amino-N-(adamant-2-yl) acetamide 11beta-hydroxysteroid dehydrogenase type 1 inhibitors.
Journal of medicinal chemistry 2007;50(1):149-64.
2007: Alejandro M S Mayer; Renee Peksa; Anne M Romanic; Michael Fay; Marcio Guzman; Mary Hall; Peer B Jacobson; Sarath P Gunasekera
Differential effects of domoic acid and E. coli lipopolysaccharide on tumor necrosis factor-alpha, transforming growth factor-beta1 and matrix metalloproteinase-9 release by rat neonatal microglia: evaluation of the direct activation hypothesis.
Marine drugs 2007;5(3):113-35.
2007: Haiyan Xu; Denise Wilcox; Phong Nguyen; Martin J Voorbach; Harriet Smith; Sevan Brodjian; Tom S Suhar; Regina M Reilly; Peer B Jacobson; Christine A Collins; Katherine Landschulz; Teresa K Surowy
Hepatic knockdown of stearoyl-CoA desaturase 1 via RNA interference in obese mice decreases lipid content and changes fatty acid composition.
Frontiers in bioscience : a journal and virtual library 2007;12():3781-94.
2007: Bradley J Backes; Gregory L Hamilton; Phong Nguyen; Denise Wilcox; Steven Fung; Jiahong Wang; Marlena Grynfarb; Annika Goos-Nilsson; Peer B Jacobson; Thomas W von Geldern
Parallel strategies for the preparation and selection of liver-targeted glucocorticoid receptor antagonists.
Bioorganic & medicinal chemistry letters 2007;17(1):40-4.
2006: Haiyan Xu; Denise Wilcox; Phong Nguyen; Martin J Voorbach; Tom S Suhar; Sheryl J Morgan; W Frank An; Lin Ge; Jack Green; Zhidan Wu; Ruth E Gimeno; Regina Reilly; Peer B Jacobson; Christine A Collins; Katherine Landschulz; Teresa K Surowy
Hepatic knockdown of mitochondrial GPAT1 in ob/ob mice improves metabolic profile.
Biochemical and biophysical research communications 2006;349(1):439-48.
2006: Dale S Edgerton; Peer B Jacobson; Terry J Opgenorth; Bradley A Zinker; David W A Beno; Thomas W von Geldern; Lars Ohman; Melanie Scott; Doss Neal; Alan D Cherrington
Selective antagonism of the hepatic glucocorticoid receptor reduces hepatic glucose production.
Metabolism: clinical and experimental 2006;55(9):1255-62.
2006: Zhili Xin; Michael D Serby; Hongyu Zhao; Christi Kosogof; Bruce G Szczepankiewicz; Mei Liu; Bo Liu; Charles W Hutchins; Kathy A Sarris; Ethan D Hoff; H Douglas Falls; Chun W Lin; Christopher A Ogiela; Christine A Collins; Michael E Brune; Eugene N Bush; Brian A Droz; Thomas A Fey; Victoria Knourek-Segel; Robin Shapiro; Peer B Jacobson; David W A Beno; Teresa M Turner; Hing L Sham; Gang Liu
Discovery and pharmacological evaluation of growth hormone secretagogue receptor antagonists.
Journal of medicinal chemistry 2006;49(15):4459-69.
2006: Michael D Serby; Hongyu Zhao; Bruce G Szczepankiewicz; Christi Kosogof; Zhili Xin; Bo Liu; Mei Liu; Lissa T J Nelson; Wiweka Kaszubska; H Douglas Falls; Verlyn G Schaefer; Eugene N Bush; Robin Shapiro; Brian A Droz; Victoria Knourek-Segel; Thomas A Fey; Michael E Brune; David W A Beno; Theresa M Turner; Christine A Collins; Peer B Jacobson; Hing L Sham; Gang Liu
2,4-diaminopyrimidine derivatives as potent growth hormone secretagogue receptor antagonists.
Journal of medicinal chemistry 2006;49(8):2568-78.
2006: Eugene N Bush; Robin Shapiro; Michael E Brune; Victoria Knourek-Segel; Brian A Droz; Thomas A Fey; Emily Lin; Peer B Jacobson
Chronic treatment with either dexfenfluramine or sibutramine in diet-switched diet-induced obese mice.
Endocrine 2006;29(2):375-81.
2006: Arthur A Hancock; Robert S Bitner; Kathleen M Krueger; S Otte; Arthur L Nikkel; Thomas A Fey; Eugene N Bush; RW Dickinson; Robin Shapiro; Victoria Knourek-Segel; Brian A Droz; Michael E Brune; Peer B Jacobson; Marlon D Cowart; Timothy A Esbenshade
Distinctions and contradistinctions between antiobesity histamine H(3) receptor (H (3)R) antagonists compared to cognition-enhancing H (3) receptor antagonists.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2006;55 Suppl 1():S42-4.
2006: Denise M Wilcox; Ruojing Yang; Sherry J Morgan; Phong T Nguyen; Martin J Voorbach; Paul Martin Jung; Deanna L Haasch; Emily Lin; Eugene N Bush; Terry J Opgenorth; Peer B Jacobson; Christine A Collins; cristina Rondinone; Teresa K Surowy; Katherine Landschulz
Delivery of RNAi reagents in murine models of obesity and diabetes.
Journal of RNAi and gene silencing : an international journal of RNA and gene targeting research 2006;3(1):225-36.
2005: Rolf Wagner; Karl W Mollison; Luping Liu; Cynthia L Henry; Teresa A Rosenberg; Nwe Y BaMaung; Noah Tu; Paul E Wiedeman; Yat Sun Or; Jay R Luly; Benjamin C Lane; James M Trevillyan; Yung-Wu Chen; Thomas A Fey; Gin C Hsieh; Kennan Marsh; Merrill E Nuss; Peer B Jacobson; Denise Wilcox; Richard P Carlson; George W Carter; Stevan W Djuric
Rapamycin analogs with reduced systemic exposure.
Bioorganic & medicinal chemistry letters 2005;15(23):5340-3.
2005: James T Link; Bryan K Sorensen; Jyoti Patel; Marlena Grynfarb; Annika Goos-Nilsson; Jiahong Wang; Steven Fung; Denise Wilcox; Bradley A Zinker; Phong Nguyen; Bach Hickman; James M Schmidt; Sue Swanson; Zhenping Tian; Thomas J Reisch; Gary Rotert; Jia Du; Ben Lane; Thomas W von Geldern; Peer B Jacobson
Antidiabetic activity of passive nonsteroidal glucocorticoid receptor modulators.
Journal of medicinal chemistry 2005;48(16):5295-304.
2005: Peer B Jacobson; Thomas W von Geldern; Lars Ohman; Marie Osterland; Jiahong Wang; Bradley A Zinker; Denise Wilcox; Phong T Nguyen; Amanda K Mika; Steven Fung; Thomas A Fey; Annika Goos-Nilsson; Marlena Grynfarb; Tomas Barkhem; Kennan Marsh; David W A Beno; Bach Nga-Nguyen; Philip R Kym; James T Link; Noah Tu; Dale S Edgerton; Alan D Cherrington; Suad Efendic; Benjamin C Lane; Terry J Opgenorth
Hepatic glucocorticoid receptor antagonism is sufficient to reduce elevated hepatic glucose output and improve glucose control in animal models of type 2 diabetes.
The Journal of pharmacology and experimental therapeutics 2005;314(1):191-200.
2005: Arthur A Hancock; Marilyn S Diehl; Thomas A Fey; Eugene N Bush; Ramin Faghih; Thomas R Miller; Kathleen M Krueger; John K Pratt; Marlon D Cowart; RW Dickinson; Robin Shapiro; Victoria Knourek-Segel; Brian A Droz; C A McDowell; G Krishna; Michael E Brune; Timothy A Esbenshade; Peer B Jacobson
Antiobesity evaluation of histamine H3 receptor (H3R) antagonist analogs of A-331440 with improved safety and efficacy.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2005;54 Suppl 1():S27-9.
2004: Arthur A Hancock; Marilyn S Diehl; Ramin Faghih; Eugene N Bush; Kathleen M Krueger; Gopala Krishna; Thomas R Miller; Denise M Wilcox; Phong Nguyen; John K Pratt; Marlon D Cowart; Timothy A Esbenshade; Peer B Jacobson
In vitro optimization of structure activity relationships of analogues of A-331440 combining radioligand receptor binding assays and micronucleus assays of potential antiobesity histamine H3 receptor antagonists.
Basic & clinical pharmacology & toxicology 2004;95(3):144-52.
2004: Thomas W von Geldern; Noah Tu; Philip R Kym; James T Link; Hwan-Soo Jae; Chunqiu Lai; Theresa Apelqvist; Patrik Rhonnstad; Lars Hagberg; Koehler F Konrad; Marlena Grynfarb; Annika Goos-Nilsson; Johnny Sandberg; Marie Osterlund; Tomas Barkhem; Marie Höglund; Jiahong Wang; Steven Fung; Denise Wilcox; Phong Nguyen; Clarissa Jakob; Charles W Hutchins; Mathias Färnegårdh; Björn Kauppi; Lars Ohman; Peer B Jacobson
Liver-selective glucocorticoid antagonists: a novel treatment for type 2 diabetes.
Journal of medicinal chemistry 2004;47(17):4213-30.
2004: Arthur A Hancock; Eugene N Bush; Peer B Jacobson; Ramin Faghih; Timothy A Esbenshade
Histamine H(3) antagonists in models of obesity.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2004;53 Suppl 1():S47-8.
2003: Michael J Coghlan; Peer B Jacobson; Ben Lane; Masaki Nakane; Chun W Lin; Steven W Elmore; Philip R Kym; Jay R Luly; George W Carter; Russell Turner; Curtis Tyree; Junlian Hu; Marc Elgort; Jon Rosen; Jeffrey N Miner
A novel antiinflammatory maintains glucocorticoid efficacy with reduced side effects.
Molecular endocrinology (Baltimore, Md.) 2003;17(5):860-9.
2003: Philip R Kym; Michael E Kort; Michael J Coghlan; Jimmie L Moore; Rui Tang; James D Ratajczyk; Daniel P Larson; Steven W Elmore; John K Pratt; Michael Stashko; H Douglas Falls; Chun W Lin; Masaki Nakane; Loan Miller; Curtis Tyree; Jeffrey N Miner; Peer B Jacobson; Denise M Wilcox; Phong Nguyen; Benjamin C Lane
Nonsteroidal selective glucocorticoid modulators: the effect of C-10 substitution on receptor selectivity and functional potency of 5-allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines.
Journal of medicinal chemistry 2003;46(6):1016-30.
2001: Steven W Elmore; Michael J Coghlan; David D Anderson; John K Pratt; Brian E Green; AX Wang; Michael Stashko; Chun W Lin; Curtis Tyree; Jeffrey N Miner; Peer B Jacobson; Denise M Wilcox; Benjamin C Lane
Nonsteroidal selective glucocorticoid modulators: the effect of C-5 alkyl substitution on the transcriptional activation/repression profile of 2,5-dihydro-10-methoxy-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines.
Journal of medicinal chemistry 2001;44(25):4481-91.
1999: Peer B Jacobson; S J Morgan; Denise M Wilcox; Phong Nguyen; C A Ratajczak; Richard P Carlson; Richard R Harris; Merrill E Nuss
A new spin on an old model: in vivo evaluation of disease progression by magnetic resonance imaging with respect to standard inflammatory parameters and histopathology in the adjuvant arthritic rat.
Arthritis and rheumatism 1999;42(10):2060-73.