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Arnaud Jacquel

Research Profile

Anatomy

Chemicals & Drugs

Physiology

Disorders

Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Procedures

Flow Cytometry

Co-author Network

Publications

TOP 3
Guillaume Robert; Sophie Tartare-Deckert; Stephanie Torino; Geneviève Bourdy; Eric Deharo; Maeva Dufies; Clémence Ginet; Arnaud Jacquel; Valérie Jullian; Frederic Peyrade; Anaïs Pottier; Patrick Auberger
Simalikalactone E (SkE), a new weapon in the armamentarium of drugs targeting cancers that exhibit constitutive activation of the ERK pathway.
Ophélie Cassuto; Alix Dubois; Maeva Dufies; Clémence Ginet; Amine Hamouda; Arnaud Jacquel; Jean-Michel Karsenti; Laurence Legros; Pascal Lenain; Frederic Luciano; Alexandre Puissant; Guillaume Robert; Jill-Patrice Cassuto; Patrick Auberger
All tyrosine kinase inhibitor-resistant chronic myelogenous cells are highly sensitive to ponatinib.
Guillaume ROBERT; Nathalie Belhacene; F Checler; T Cluzeau; Pascal Colosetti; C A Da Costa; M Dufies; Arnaud Jacquel; P Kahle; Frederic Luciano; S Marchetti; A Puissant; Patrick Auberger
The caspase 6 derived N-terminal fragment of DJ-1 promotes apoptosis via increased ROS production.

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All Publications

2012: Guillaume Robert; Sophie Tartare-Deckert; Stephanie Torino; Geneviève Bourdy; Eric Deharo; Maeva Dufies; Clémence Ginet; Arnaud Jacquel; Valérie Jullian; Frederic Peyrade; Anaïs Pottier; Patrick Auberger
Simalikalactone E (SkE), a new weapon in the armamentarium of drugs targeting cancers that exhibit constitutive activation of the ERK pathway.
Oncotarget 2012;3(12):1688-99.
2012: Ophélie Cassuto; Alix Dubois; Maeva Dufies; Clémence Ginet; Amine Hamouda; Arnaud Jacquel; Jean-Michel Karsenti; Laurence Legros; Pascal Lenain; Frederic Luciano; Alexandre Puissant; Guillaume Robert; Jill-Patrice Cassuto; Patrick Auberger
All tyrosine kinase inhibitor-resistant chronic myelogenous cells are highly sensitive to ponatinib.
Oncotarget 2012;3(12):1557-65.
2012: Guillaume ROBERT; Nathalie Belhacene; F Checler; T Cluzeau; Pascal Colosetti; C A Da Costa; M Dufies; Arnaud Jacquel; P Kahle; Frederic Luciano; S Marchetti; A Puissant; Patrick Auberger
The caspase 6 derived N-terminal fragment of DJ-1 promotes apoptosis via increased ROS production.
Cell death and differentiation 2012;19(11):1769-78.
2012: Alexandre Puissant; Sophie Raynaud; Guillaume ROBERT; Mélanie Tichet; Issam Ben Sahra; Jill-Patrice Cassuto; Yann Chéli; Thomas Cluzeau; Marcel Deckert; Maeva Dufies; Nina Fenouille; Arnaud Jacquel; Laurence Legros; Frederic Luciano; François-Xavier Mahon; Jean-Max Pasquet; Patrick Auberger
Imatinib triggers mesenchymal-like conversion of CML cells associated with increased aggressiveness.
Journal of molecular cell biology 2012;4(4):207-20.
2012: Arnaud Jacquel; Sandrine Obba; Eric Solary; Patrick Auberger
Proper macrophagic differentiation requires both autophagy and caspase activation.
Autophagy 2012;8(7):1141-3.
2012: Arnaud Jacquel; emmanuel lemichez; Frederic Luciano; Sandrine Obba; Guillaume ROBERT; Eric Solary; Laurent Boyer; Maeva Dufies; Pierre GOUNON; Patrick Auberger
Autophagy is required for CSF-1-induced macrophagic differentiation and acquisition of phagocytic functions.
Blood 2012;119(19):4527-31.
2012: Thomas Cluzeau; Maeva Dufies; Arnaud Jacquel; Jean Michel Karsenti; Frederic Luciano; Nicolas Mounier; Claude Preudhomme; Alexandre Puissant; Sophie Raynaud; Aline Renneville; Guillaume ROBERT; Jill-Patrice Cassuto; Patrick Auberger
BCL2L10 is a predictive factor for resistance to azacitidine in MDS and AML patients.
Oncotarget 2012;3(4):490-501.
2012: Guillaume ROBERT; Alexandre Puissant; John C Reed; Patrick Auberger; Nathalie Belhacene; Pascal Colosetti; Maeva Dufies; Cecile Gastaldi; Amine Hamouda; Arnaud Jacquel; Fréderic Luciano
The anti-apoptotic Bcl-B protein inhibits BECN1-dependent autophagic cell death.
Autophagy 2012;8(4):637-49.
2012: Nathalie Belhacéne; Marie Beneteau; Pascal Colosetti; Parvati Gamas; Diogo Gonçalvès; Arnaud Jacquel; Marie Jacquin; Jean-Ehrland Ricci; Abdellilah Wakkach; Patrick Auberger; Sandrine Marchetti
Severe thymic atrophy in a mouse model of skin inflammation accounts for impaired TNFR1 signaling.
PloS one 2012;7(10):e47321.
2011: Leslie Guery; Arnaud Jacquel; Gaetan Jego; Bénédicte Manoury; Catherine Paul; Naïma Benikhlef; Radj Cally; Nathalie M Droin; Erick Dufour; Thomas Gautier; Tom Vanden Berghe; Peter Vandenabeele; Eric Solary
Fine-tuning nucleophosmin in macrophage differentiation and activation.
Blood 2011;118(17):4694-704.
2011: Didier Colin; Anne Athias; Philippe Gambert; Aziz Hichami; Arnaud Jacquel; Sylvie Jeanningros; Norbert Latruffe; Emeric Limagne; Gérard Lizard; Eric Solary; Dominique Delmas
Endocytosis of resveratrol via lipid rafts and activation of downstream signaling pathways in cancer cells.
Cancer prevention research (Philadelphia, Pa.) 2011;4(7):1095-106.
2011: Benoist Pruvot; Arnaud Jacquel; Nathalie Droin; Patrick Auberger; Didier Bouscary; Jérome Tamburini; Marc Muller; Michaëla Fontenay; JOHANNA CHLUBA; Eric Solary
Leukemic cell xenograft in zebrafish embryo for investigating drug efficacy.
Haematologica 2011;96(4):612-6.
2010: Nina Fenouille; Alexandre Puissant; Maeva Dufies; Guillaume Robert; Arnaud Jacquel; Mickael Ohanna; Marcel Deckert; Jean-Max Pasquet; François-Xavier Mahon; Jill-Patrice Cassuto; Sophie Raynaud; Sophie Tartare-Deckert; Patrick Auberger
Persistent activation of the Fyn/ERK kinase signaling axis mediates imatinib resistance in chronic myelogenous leukemia cells through upregulation of intracellular SPARC.
Cancer research 2010;70(23):9659-70.
2010: J Paggetti; A Largeot; R Aucagne; Arnaud Jacquel; B Lagrange; X-J Yang; Eric Solary; J-N Bastie; Laurent Delva
Crosstalk between leukemia-associated proteins MOZ and MLL regulates HOX gene expression in human cord blood CD34+ cells.
Oncogene 2010;29(36):5019-31.
2010: Nathalie M Droin; Arnaud Jacquel; Jean-Baptiste Hendra; Cindy Racoeur; Caroline Truntzer; Delphine Pecqueur; Naïma Benikhlef; Marion Ciudad; Leslie Guery; Valérie Jooste; Erick Dufour; Pierre Fenaux; Bruno Quesnel; Olivier Kosmider; Michaëla Fontenay; Patrick Ducoroy; Eric Solary
Alpha-defensins secreted by dysplastic granulocytes inhibit the differentiation of monocytes in chronic myelomonocytic leukemia.
Blood 2010;115(1):78-88.
2009: Pascal Colosetti; Alexandre Puissant; Guillaume Robert; Fréderic Luciano; Arnaud Jacquel; Pierre GOUNON; Jill-Patrice Cassuto; Patrick Auberger
Autophagy is an important event for megakaryocytic differentiation of the chronic myelogenous leukemia K562 cell line.
Autophagy 2009;5(8):1092-8.
2009: Arnaud Jacquel; Naïma Benikhlef; Jérôme Paggetti; Najoua LALAOUI; Leslie Guery; Erick K Dufour; Marion Ciudad; Cindy Racoeur; Olivier Micheau; Laurent Delva; Nathalie M Droin; Eric Solary
Colony-stimulating factor-1-induced oscillations in phosphatidylinositol-3 kinase/AKT are required for caspase activation in monocytes undergoing differentiation into macrophages.
Blood 2009;114(17):3633-41.
2009: Sébastien Grosso; Alexandre Puissant; Maeva Dufies; Pascal Colosetti; Arnaud Jacquel; Kevin Lebrigand; Pascal Barbry; Marcel Deckert; Jill-Patrice Cassuto; Bernard Mari; Patrick Auberger
Gene expression profiling of imatinib and PD166326-resistant CML cell lines identifies Fyn as a gene associated with resistance to BCR-ABL inhibitors.
Molecular cancer therapeutics 2009;8(7):1924-33.
2009: Vanessa J Lavallard; Ludivine A Pradelli; Audrey Paul; Marie Bénéteau; Arnaud Jacquel; Patrick Auberger; Jean-Ehrland Ricci
Modulation of caspase-independent cell death leads to resensitization of imatinib mesylate-resistant cells.
Cancer research 2009;69(7):3013-20.
2009: Nathalie Droin; Arnaud Jacquel; Leslie Guery; Erick Dufour; Carmen Garrido; Eric Solary
Various functions of caspases in hematopoiesis.
Frontiers in bioscience : a journal and virtual library 2009;14():2358-71.
2008: Alexandre Puissant; Sebastien Grosso; Arnaud Jacquel; Nathalie Belhacene; Pascal Colosetti; Jill-Patrice Cassuto; Patrick Auberger
Imatinib mesylate-resistant human chronic myelogenous leukemia cell lines exhibit high sensitivity to the phytoalexin resveratrol.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(6):1894-904.
2008: Nathalie M Droin; Séverine Cathelin; Arnaud Jacquel; Leslie Guéry; Carmen Garrido; Michaëla Fontenay; Olivier Hermine; Eric Solary
A role for caspases in the differentiation of erythroid cells and macrophages.
Biochimie 2008;90(2):416-22.
2007: Arnaud Jacquel; Pascal Colosetti; S Grosso; Nathalie Belhacene; A Puissant; Sandrine Marchetti; Jean-Philippe Breittmayer; Patrick Auberger
Apoptosis and erythroid differentiation triggered by Bcr-Abl inhibitors in CML cell lines are fully distinguishable processes that exhibit different sensitivity to caspase inhibition.
Oncogene 2007;26(17):2445-58.
2006: Olivia Fromigué; Eric Haÿ; Dominique Modrowski; S Bouvet; Arnaud Jacquel; Patrick Auberger; Pierre J Marie
RhoA GTPase inactivation by statins induces osteosarcoma cell apoptosis by inhibiting p42/p44-MAPKs-Bcl-2 signaling independently of BMP-2 and cell differentiation.
Cell death and differentiation 2006;13(11):1845-56.
2006: Christine Bourcier; Arnaud Jacquel; Jochen Hess; Isabelle Peyrottes; Peter Angel; Paul Hofman; Patrick Auberger; Jacques Pouysségur; Gilles Pagès
p44 mitogen-activated protein kinase (extracellular signal-regulated kinase 1)-dependent signaling contributes to epithelial skin carcinogenesis.
Cancer research 2006;66(5):2700-7.
2006: Arnaud Jacquel; Magali Herrant; Virginie Defamie; Nathalie Belhacene; Pascal Colosetti; Sandrine Marchetti; Laurence Legros; Marcel Deckert; Bernard Mari; Jill-Patrice Cassuto; Paul Hofman; Patrick Auberger
A survey of the signaling pathways involved in megakaryocytic differentiation of the human K562 leukemia cell line by molecular and c-DNA array analysis.
Oncogene 2006;25(5):781-94.
2004: Magali Herrant; Arnaud Jacquel; Sandrine Marchetti; Nathalie Belhacène; Pascal Colosetti; Frederic Luciano; Patrick Auberger
Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis.
Oncogene 2004;23(47):7863-73.
2004: Laurence Legros; Christine Bourcier; Arnaud Jacquel; François-Xavier Mahon; Jill-Patrice Cassuto; Patrick Auberger; Gilles Pagès
Imatinib mesylate (STI571) decreases the vascular endothelial growth factor plasma concentration in patients with chronic myeloid leukemia.
Blood 2004;104(2):495-501.
2003: Arnaud Jacquel; Magali Herrant; Laurence Legros; Nathalie Belhacene; Frederic Luciano; Gilles Pages; Paul Hofman; Patrick Auberger
Imatinib induces mitochondria-dependent apoptosis of the Bcr-Abl-positive K562 cell line and its differentiation toward the erythroid lineage.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(14):2160-2.
2003: Frederic Luciano; Arnaud Jacquel; Pascal Colosetti; Magali Herrant; Sebastien Cagnol; Gilles Pages; Patrick Auberger
Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function.
Oncogene 2003;22(43):6785-93.
2003: Céline Charvet; Isabelle Alberti; Frederic Luciano; Arnaud Jacquel; Alain Bernard; Patrick Auberger; Marcel Deckert
Proteolytic regulation of Forkhead transcription factor FOXO3a by caspase-3-like proteases.
Oncogene 2003;22(29):4557-68.
2003: Frederic Luciano; Magali Herrant; Arnaud Jacquel; Jean-Ehrland Ricci; Patrick Auberger
The p54 cleaved form of the tyrosine kinase Lyn generated by caspases during BCR-induced cell death in B lymphoma acts as a negative regulator of apoptosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(6):711-3.