Rudolf Jaenisch

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Bröske Ann-Marie; Vockentanz Lena; Kharazi Shabnam; Huska Matthew R; Mancini Elena; Scheller Marina; Kuhl Christiane; Enns Andreas; Prinz Marco; Jaenisch Rudolf; Nerlov Claus; Leutz Achim; Andrade-Navarro Miguel A; Jacobsen Sten Eirik W; Rosenbauer Frank
DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction.
Hockemeyer Dirk; Soldner Frank; Beard Caroline; Gao Qing; Mitalipova Maisam; DeKelver Russell C; Katibah George E; Amora Ranier; Boydston Elizabeth A; Zeitler Bryan; Meng Xiangdong; Miller Jeffrey C; Zhang Lei; Rebar Edward J; Gregory Philip D; Urnov Fyodor D; Jaenisch Rudolf
Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases.
Rao Prakash K; Toyama Yumiko; Chiang H Rosaria; Gupta Sumeet; Bauer Michael; Medvid Rostislav; Reinhardt Ferenc; Liao Ronglih; Krieger Monty; Jaenisch Rudolf; Lodish Harvey F; Blelloch Robert
Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure.

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2009: Bröske Ann-Marie; Vockentanz Lena; Kharazi Shabnam; Huska Matthew R; Mancini Elena; Scheller Marina; Kuhl Christiane; Enns Andreas; Prinz Marco; Jaenisch Rudolf; Nerlov Claus; Leutz Achim; Andrade-Navarro Miguel A; Jacobsen Sten Eirik W; Rosenbauer Frank
DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction.
Nature genetics 2009;41(11):1207-15.
2009: Hockemeyer Dirk; Soldner Frank; Beard Caroline; Gao Qing; Mitalipova Maisam; DeKelver Russell C; Katibah George E; Amora Ranier; Boydston Elizabeth A; Zeitler Bryan; Meng Xiangdong; Miller Jeffrey C; Zhang Lei; Rebar Edward J; Gregory Philip D; Urnov Fyodor D; Jaenisch Rudolf
Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases.
Nature biotechnology 2009;27(9):851-7.
2009: Rao Prakash K; Toyama Yumiko; Chiang H Rosaria; Gupta Sumeet; Bauer Michael; Medvid Rostislav; Reinhardt Ferenc; Liao Ronglih; Krieger Monty; Jaenisch Rudolf; Lodish Harvey F; Blelloch Robert
Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure.
Circulation research 2009;105(6):585-94.
2009: Jaenisch R
Stem cells, pluripotency and nuclear reprogramming.
Journal of thrombosis and haemostasis : JTH 2009;7 Suppl 1():21-3.
2009: Nosho Katsuhiko; Shima Kaori; Irahara Natsumi; Kure Shoko; Baba Yoshifumi; Kirkner Gregory J; Chen Li; Gokhale Sumita; Hazra Aditi; Spiegelman Donna; Giovannucci Edward L; Jaenisch Rudolf; Fuchs Charles S; Ogino Shuji
DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(11):3663-71.
2009: Lyssiotis Costas A; Foreman Ruth K; Staerk Judith; Garcia Michael; Mathur Divya; Markoulaki Styliani; Hanna Jacob; Lairson Luke L; Charette Bradley D; Bouchez Laure C; Bollong Michael; Kunick Conrad; Brinker Achim; Cho Charles Y; Schultz Peter G; Jaenisch Rudolf
Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(22):8912-7.
2009: Hanna Jacob; Markoulaki Styliani; Mitalipova Maisam; Cheng Albert W; Cassady John P; Staerk Judith; Carey Bryce W; Lengner Christopher J; Foreman Ruth; Love Jennifer; Gao Qing; Kim Jongpil; Jaenisch Rudolf
Metastable pluripotent states in NOD-mouse-derived ESCs.
Cell stem cell 2009;4(6):513-24.
2009: Guan Ji-Song; Haggarty Stephen J; Giacometti Emanuela; Dannenberg Jan-Hermen; Joseph Nadine; Gao Jun; Nieland Thomas J F; Zhou Ying; Wang Xinyu; Mazitschek Ralph; Bradner James E; DePinho Ronald A; Jaenisch Rudolf; Tsai Li-Huei
HDAC2 negatively regulates memory formation and synaptic plasticity.
Nature 2009;459(7243):55-60.
2009: Han Dong Wook; Do Jeong Tae; Araúzo-Bravo Marcos J; Lee Sung Ho; Meissner Alexander; Lee Hoon Taek; Jaenisch Rudolf; Schöler Hans R
Epigenetic hierarchy governing Nestin expression.
Stem cells (Dayton, Ohio) 2009;27(5):1088-97.
2009: Soldner Frank; Hockemeyer Dirk; Beard Caroline; Gao Qing; Bell George W; Cook Elizabeth G; Hargus Gunnar; Blak Alexandra; Cooper Oliver; Mitalipova Maisam; Isacson Ole; Jaenisch Rudolf
Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors.
Cell 2009;136(5):964-77.
2009: Daley George Q; Lensch M William; Jaenisch Rudolf; Meissner Alex; Plath Kathrin; Yamanaka Shinya
Broader implications of defining standards for the pluripotency of iPSCs.
Cell stem cell 2009;4(3):200-1; author reply 202.
2009: Tao Jifang; Hu Keping; Chang Qiang; Wu Hao; Sherman Nicholas E; Martinowich Keri; Klose Robert J; Schanen Carolyn; Jaenisch Rudolf; Wang Weidong; Sun Yi Eve
Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(12):4882-7.
2009: Guttman Mitchell; Amit Ido; Garber Manuel; French Courtney; Lin Michael F; Feldser David; Huarte Maite; Zuk Or; Carey Bryce W; Cassady John P; Cabili Moran N; Jaenisch Rudolf; Mikkelsen Tarjei S; Jacks Tyler; Hacohen Nir; Bernstein Bradley E; Kellis Manolis; Regev Aviv; Rinn John L; Lander Eric S
Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals.
Nature 2009;458(7235):223-7.
2009: Tropea Daniela; Giacometti Emanuela; Wilson Nathan R; Beard Caroline; McCurry Cortina; Fu Dong Dong; Flannery Ruth; Jaenisch Rudolf; Sur Mriganka
Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(6):2029-34.
2009: Markoulaki Styliani; Hanna Jacob; Beard Caroline; Carey Bryce W; Cheng Albert W; Lengner Christopher J; Dausman Jessica A; Fu Dongdong; Gao Qing; Wu Su; Cassady John P; Jaenisch Rudolf
Transgenic mice with defined combinations of drug-inducible reprogramming factors.
Nature biotechnology 2009;27(2):169-71.
2009: Skelley Alison M; Kirak Oktay; Suh Heikyung; Jaenisch Rudolf; Voldman Joel
Microfluidic control of cell pairing and fusion.
Nature methods 2009;6(2):147-52.
2009: Carey Bryce W; Markoulaki Styliani; Hanna Jacob; Saha Kris; Gao Qing; Mitalipova Maisam; Jaenisch Rudolf
Reprogramming of murine and human somatic cells using a single polycistronic vector.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(1):157-62.
2009: Foudi Adlen; Hochedlinger Konrad; Van Buren Denille; Schindler Jeffrey W; Jaenisch Rudolf; Carey Vincent; Hock Hanno
Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells.
Nature biotechnology 2009;27(1):84-90.
2009: Linhart Heinz G; Troen Aron; Bell George W; Cantu Erika; Chao Wei-Hsun; Moran Eva; Steine Eveline; He Timothy; Jaenisch Rudolf
Folate deficiency induces genomic uracil misincorporation and hypomethylation but does not increase DNA point mutations.
Gastroenterology 2009;136(1):227-235.e3.
2009: Pfannkuche Kurt; Liang Huamin; Hannes Tobias; Xi Jiaoya; Fatima Azra; Nguemo Filomain; Matzkies Matthias; Wernig Marius; Jaenisch Rudolf; Pillekamp Frank; Halbach Marcel; Schunkert Heribert; Saric Tomo; Hescheler Juergen; Reppel Michael
Cardiac myocytes derived from murine reprogrammed fibroblasts: intact hormonal regulation, cardiac ion channel expression and development of contractility.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009;24(1-2):73-86.
2008: Jaenisch Rudolf
Celebrating 10 years of hESC lines: an interview with Rudolf Jaenisch.
Stem cells (Dayton, Ohio) 2008;26(12):3005-7.
2008: Creyghton Menno P; Markoulaki Styliani; Levine Stuart S; Hanna Jacob; Lodato Michael A; Sha Ky; Young Richard A; Jaenisch Rudolf; Boyer Laurie A
H2AZ is enriched at polycomb complex target genes in ES cells and is necessary for lineage commitment.
Cell 2008;135(4):649-61.
2008: Green Jordan J; Zhou Betty Y; Mitalipova Maisam M; Beard Caroline; Langer Robert; Jaenisch Rudolf; Anderson Daniel G
Nanoparticles for gene transfer to human embryonic stem cell colonies.
Nano letters 2008;8(10):3126-30.
2008: Eminli Sarah; Utikal Jochen; Arnold Katrin; Jaenisch Rudolf; Hochedlinger Konrad
Reprogramming of neural progenitor cells into induced pluripotent stem cells in the absence of exogenous Sox2 expression.
Stem cells (Dayton, Ohio) 2008;26(10):2467-74.
2008: Hockemeyer Dirk; Soldner Frank; Cook Elizabeth G; Gao Qing; Mitalipova Maisam; Jaenisch Rudolf
A drug-inducible system for direct reprogramming of human somatic cells to pluripotency.
Cell stem cell 2008;3(3):346-53.
2008: Marson Alexander; Levine Stuart S; Cole Megan F; Frampton Garrett M; Brambrink Tobias; Johnstone Sarah; Guenther Matthew G; Johnston Wendy K; Wernig Marius; Newman Jamie; Calabrese J Mauro; Dennis Lucas M; Volkert Thomas L; Gupta Sumeet; Love Jennifer; Hannett Nancy; Sharp Phillip A; Bartel David P; Jaenisch Rudolf; Young Richard A
Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells.
Cell 2008;134(3):521-33.
2008: Marson Alexander; Foreman Ruth; Chevalier Brett; Bilodeau Steve; Kahn Michael; Young Richard A; Jaenisch Rudolf
Wnt signaling promotes reprogramming of somatic cells to pluripotency.
Cell stem cell 2008;3(2):132-5.
2008: Meissner Alexander; Mikkelsen Tarjei S; Gu Hongcang; Wernig Marius; Hanna Jacob; Sivachenko Andrey; Zhang Xiaolan; Bernstein Bradley E; Nusbaum Chad; Jaffe David B; Gnirke Andreas; Jaenisch Rudolf; Lander Eric S
Genome-scale DNA methylation maps of pluripotent and differentiated cells.
Nature 2008;454(7205):766-70.
2008: Wernig Marius; Lengner Christopher J; Hanna Jacob; Lodato Michael A; Steine Eveline; Foreman Ruth; Staerk Judith; Markoulaki Styliani; Jaenisch Rudolf
A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types.
Nature biotechnology 2008;26(8):916-24.
2008: Kronenberg Golo; Harms Christoph; Sobol Robert W; Cardozo-Pelaez Fernando; Linhart Heinz; Winter Benjamin; Balkaya Mustafa; Gertz Karen; Gay Shanna B; Cox David; Eckart Sarah; Ahmadi Michael; Juckel Georg; Kempermann Gerd; Hellweg Rainer; Sohr Reinhard; Hörtnagl Heide; Wilson Samuel H; Jaenisch Rudolf; Endres Matthias
Folate deficiency induces neurodegeneration and brain dysfunction in mice lacking uracil DNA glycosylase.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(28):7219-30.
2008: Mikkelsen Tarjei S; Hanna Jacob; Zhang Xiaolan; Ku Manching; Wernig Marius; Schorderet Patrick; Bernstein Bradley E; Jaenisch Rudolf; Lander Eric S; Meissner Alexander
Dissecting direct reprogramming through integrative genomic analysis.
Nature 2008;454(7200):49-55.
2008: Markoulaki Styliani; Meissner Alexander; Jaenisch Rudolf
Somatic cell nuclear transfer and derivation of embryonic stem cells in the mouse.
Methods (San Diego, Calif.) 2008;45(2):101-14.
2008: Hirasawa Ryutaro; Chiba Hatsune; Kaneda Masahiro; Tajima Shoji; Li En; Jaenisch Rudolf; Sasaki Hiroyuki
Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development.
Genes & development 2008;22(12):1607-16.
2008: Hanna Jacob; Markoulaki Styliani; Schorderet Patrick; Carey Bryce W; Beard Caroline; Wernig Marius; Creyghton Menno P; Steine Eveline J; Cassady John P; Foreman Ruth; Lengner Christopher J; Dausman Jessica A; Jaenisch Rudolf
Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency.
Cell 2008;133(2):250-64.
2008: Wernig Marius; Zhao Jian-Ping; Pruszak Jan; Hedlund Eva; Fu Dongdong; Soldner Frank; Broccoli Vania; Constantine-Paton Martha; Isacson Ole; Jaenisch Rudolf
Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(15):5856-61.
2008: Ventura Andrea; Young Amanda G; Winslow Monte M; Lintault Laura; Meissner Alex; Erkeland Stefan J; Newman Jamie; Bronson Roderick T; Crowley Denise; Stone James R; Jaenisch Rudolf; Sharp Phillip A; Jacks Tyler
Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters.
Cell 2008;132(5):875-86.
2008: Lengner Christopher J; Welstead G Grant; Jaenisch Rudolf
The pluripotency regulator Oct4: a role in somatic stem cells?
Cell cycle (Georgetown, Tex.) 2008;7(6):725-8.
2008: Fouse Shaun D; Shen Yin; Pellegrini Matteo; Cole Steve; Meissner Alexander; Van Neste Leander; Jaenisch Rudolf; Fan Guoping
Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation.
Cell stem cell 2008;2(2):160-9.
2008: Brambrink Tobias; Foreman Ruth; Welstead G Grant; Lengner Christopher J; Wernig Marius; Suh Heikyung; Jaenisch Rudolf
Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells.
Cell stem cell 2008;2(2):151-9.
2008: Jaenisch Rudolf; Young Richard
Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming.
Cell 2008;132(4):567-82.
2008: Wernig Marius; Meissner Alexander; Cassady John P; Jaenisch Rudolf
c-Myc is dispensable for direct reprogramming of mouse fibroblasts.
Cell stem cell 2008;2(1):10-2.
2008: Howard G; Eiges R; Gaudet F; Jaenisch R; Eden A
Activation and transposition of endogenous retroviral elements in hypomethylation induced tumors in mice.
Oncogene 2008;27(3):404-8.
2008: Welstead G Grant; Brambrink Tobias; Jaenisch Rudolf
Generating iPS cells from MEFS through forced expression of Sox-2, Oct-4, c-Myc, and Klf4.
Journal of visualized experiments : JoVE 2008;(14):.
2008: Hanna J; Carey B W; Jaenisch R
Reprogramming of somatic cell identity.
Cold Spring Harbor symposia on quantitative biology 2008;73():147-55.
2008: Mathur Divya; Danford Timothy W; Boyer Laurie A; Young Richard A; Gifford David K; Jaenisch Rudolf
Analysis of the mouse embryonic stem cell regulatory networks obtained by ChIP-chip and ChIP-PET.
Genome biology 2008;9(8):R126.
2007: Hanna Jacob; Wernig Marius; Markoulaki Styliani; Sun Chiao-Wang; Meissner Alexander; Cassady John P; Beard Caroline; Brambrink Tobias; Wu Li-Chen; Townes Tim M; Jaenisch Rudolf
Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin.
Science (New York, N.Y.) 2007;318(5858):1920-3.
2007: Linhart Heinz G; Lin Haijiang; Yamada Yasuhiro; Moran Eva; Steine Eveline J; Gokhale Sumita; Lo Grace; Cantu Erika; Ehrich Mathias; He Timothy; Meissner Alex; Jaenisch Rudolf
Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing.
Genes & development 2007;21(23):3110-22.
2007: Camargo Fernando D; Gokhale Sumita; Johnnidis Jonathan B; Fu Dongdong; Bell George W; Jaenisch Rudolf; Brummelkamp Thijn R
YAP1 increases organ size and expands undifferentiated progenitor cells.
Current biology : CB 2007;17(23):2054-60.
2007: Hyun Insoo; Hochedlinger Konrad; Jaenisch Rudolf; Yamanaka Shinya
New advances in iPS cell research do not obviate the need for human embryonic stem cells.
Cell stem cell 2007;1(4):367-8.
2007: Lengner Christopher J; Camargo Fernando D; Hochedlinger Konrad; Welstead G Grant; Zaidi Samir; Gokhale Sumita; Scholer Hans R; Tomilin Alexey; Jaenisch Rudolf
Oct4 expression is not required for mouse somatic stem cell self-renewal.
Cell stem cell 2007;1(4):403-15.
2007: Meissner Alexander; Wernig Marius; Jaenisch Rudolf
Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells.
Nature biotechnology 2007;25(10):1177-81.
2007: Kim Kitai; Ng Kitwa; Rugg-Gunn Peter J; Shieh Jae-Hung; Kirak Oktay; Jaenisch Rudolf; Wakayama Teruhiko; Moore Malcolm A; Pedersen Roger A; Daley George Q
Recombination signatures distinguish embryonic stem cells derived by parthenogenesis and somatic cell nuclear transfer.
Cell stem cell 2007;1(3):346-52.
2007: Mikkelsen Tarjei S; Ku Manching; Jaffe David B; Issac Biju; Lieberman Erez; Giannoukos Georgia; Alvarez Pablo; Brockman William; Kim Tae-Kyung; Koche Richard P; Lee William; Mendenhall Eric; O'Donovan Aisling; Presser Aviva; Russ Carsten; Xie Xiaohui; Meissner Alexander; Wernig Marius; Jaenisch Rudolf; Nusbaum Chad; Lander Eric S; Bernstein Bradley E
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells.
Nature 2007;448(7153):553-60.
2007: Guenther Matthew G; Levine Stuart S; Boyer Laurie A; Jaenisch Rudolf; Young Richard A
A chromatin landmark and transcription initiation at most promoters in human cells.
Cell 2007;130(1):77-88.
2007: Serwold Thomas; Hochedlinger Konrad; Inlay Matthew A; Jaenisch Rudolf; Weissman Irving L
Early TCR expression and aberrant T cell development in mice with endogenous prerearranged T cell receptor genes.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(2):928-38.
2007: Wernig Marius; Meissner Alexander; Foreman Ruth; Brambrink Tobias; Ku Manching; Hochedlinger Konrad; Bernstein Bradley E; Jaenisch Rudolf
In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state.
Nature 2007;448(7151):318-24.
2007: Maherali Nimet; Sridharan Rupa; Xie Wei; Utikal Jochen; Eminli Sarah; Arnold Katrin; Stadtfeld Matthias; Yachechko Robin; Tchieu Jason; Jaenisch Rudolf; Plath Kathrin; Hochedlinger Konrad
Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution.
Cell stem cell 2007;1(1):55-70.
2007: Nguyen Suzanne; Meletis Konstantinos; Fu Dongdong; Jhaveri Sonal; Jaenisch Rudolf
Ablation of de novo DNA methyltransferase Dnmt3a in the nervous system leads to neuromuscular defects and shortened lifespan.
Developmental dynamics : an official publication of the American Association of Anatomists 2007;236(6):1663-76.
2007: Hansson Mats G; Helgesson Gert; Wessman Richard; Jaenisch Rudolf
Commentary: isolated stem cells--patentable as cultural artifacts?
Stem cells (Dayton, Ohio) 2007;25(6):1507-10.
2007: Zhang Jing; Liu Yangang; Beard Caroline; Tuveson David A; Jaenisch Rudolf; Jacks Tyler E; Lodish Harvey F
Expression of oncogenic K-ras from its endogenous promoter leads to a partial block of erythroid differentiation and hyperactivation of cytokine-dependent signaling pathways.
Blood 2007;109(12):5238-41.
2007: Shaw Alice T; Meissner Alexander; Dowdle James A; Crowley Denise; Magendantz Margaret; Ouyang Chensi; Parisi Tiziana; Rajagopal Jayaraj; Blank Leah J; Bronson Roderick T; Stone James R; Tuveson David A; Jaenisch Rudolf; Jacks Tyler
Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis.
Genes & development 2007;21(6):694-707.
2007: Wang Yangming; Medvid Rostislav; Melton Collin; Jaenisch Rudolf; Blelloch Robert
DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal.
Nature genetics 2007;39(3):380-5.
2007: Giacometti Emanuela; Luikenhuis Sandra; Beard Caroline; Jaenisch Rudolf
Partial rescue of MeCP2 deficiency by postnatal activation of MeCP2.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(6):1931-6.
2007: Hochedlinger Konrad; Jaenisch Rudolf
On the cloning of animals from terminally differentiated cells.
Nature genetics 2007;39(2):136-7; author reply 137-8.
2007: Siegmund Kimberly D; Connor Caroline M; Campan Mihaela; Long Tiffany I; Weisenberger Daniel J; Biniszkiewicz Detlev; Jaenisch Rudolf; Laird Peter W; Akbarian Schahram
DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons.
PloS one 2007;2(9):e895.
2006: Savarese Fabio; Flahndorfer Katja; Jaenisch Rudolf; Busslinger Meinrad; Wutz Anton
Hematopoietic precursor cells transiently reestablish permissiveness for X inactivation.
Molecular and cellular biology 2006;26(19):7167-77.
2006: Boyer Laurie A; Mathur Divya; Jaenisch Rudolf
Molecular control of pluripotency.
Current opinion in genetics & development 2006;16(5):455-62.
2006: Meissner Alexander; Jaenisch Rudolf
Mammalian nuclear transfer.
Developmental dynamics : an official publication of the American Association of Anatomists 2006;235(9):2460-9.
2006: Blelloch Robert; Wang Zhongde; Meissner Alex; Pollard Steven; Smith Austin; Jaenisch Rudolf
Reprogramming efficiency following somatic cell nuclear transfer is influenced by the differentiation and methylation state of the donor nucleus.
Stem cells (Dayton, Ohio) 2006;24(9):2007-13.
2006: Hochedlinger Konrad; Jaenisch Rudolf
Nuclear reprogramming and pluripotency.
Nature 2006;441(7097):1061-7.
2006: Shimazu Kazuhiro; Zhao Mingrui; Sakata Kazuko; Akbarian Schahram; Bates Brian; Jaenisch Rudolf; Lu Bai
NT-3 facilitates hippocampal plasticity and learning and memory by regulating neurogenesis.
Learning & memory (Cold Spring Harbor, N.Y.) 2006;13(3):307-15.
2006: Boyer Laurie A; Plath Kathrin; Zeitlinger Julia; Brambrink Tobias; Medeiros Lea A; Lee Tong Ihn; Levine Stuart S; Wernig Marius; Tajonar Adriana; Ray Mridula K; Bell George W; Otte Arie P; Vidal Miguel; Gifford David K; Young Richard A; Jaenisch Rudolf
Polycomb complexes repress developmental regulators in murine embryonic stem cells.
Nature 2006;441(7091):349-53.
2006: Bernstein Bradley E; Mikkelsen Tarjei S; Xie Xiaohui; Kamal Michael; Huebert Dana J; Cuff James; Fry Ben; Meissner Alex; Wernig Marius; Plath Kathrin; Jaenisch Rudolf; Wagschal Alexandre; Feil Robert; Schreiber Stuart L; Lander Eric S
A bivalent chromatin structure marks key developmental genes in embryonic stem cells.
Cell 2006;125(2):315-26.
2006: Lee Tong Ihn; Jenner Richard G; Boyer Laurie A; Guenther Matthew G; Levine Stuart S; Kumar Roshan M; Chevalier Brett; Johnstone Sarah E; Cole Megan F; Isono Kyo-ichi; Koseki Haruhiko; Fuchikami Takuya; Abe Kuniya; Murray Heather L; Zucker Jacob P; Yuan Bingbing; Bell George W; Herbolsheimer Elizabeth; Hannett Nancy M; Sun Kaiming; Odom Duncan T; Otte Arie P; Volkert Thomas L; Bartel David P; Melton Douglas A; Gifford David K; Jaenisch Rudolf; Young Richard A
Control of developmental regulators by Polycomb in human embryonic stem cells.
Cell 2006;125(2):301-13.
2006: Lin Haijiang; Yamada Yasuhiro; Nguyen Suzanne; Linhart Heinz; Jackson-Grusby Laurie; Meissner Alexander; Meletis Konstantinos; Lo Grace; Jaenisch Rudolf
Suppression of intestinal neoplasia by deletion of Dnmt3b.
Molecular and cellular biology 2006;26(8):2976-83.
2006: Jaenisch Rudolf; Meissner Alex
Politically correct human embryonic stem cells?
The New England journal of medicine 2006;354(11):1208-9; author reply 1208-9.
2006: Rios Maribel; Lambe Evelyn K; Liu Rongjian; Teillon Sarah; Liu JinHong; Akbarian Schahram; Roffler-Tarlov Suzanne; Jaenisch Rudolf; Aghajanian George K
Severe deficits in 5-HT2A -mediated neurotransmission in BDNF conditional mutant mice.
Journal of neurobiology 2006;66(4):408-20.
2006: Gemelli Terry; Berton Olivier; Nelson Erika D; Perrotti Linda I; Jaenisch Rudolf; Monteggia Lisa M
Postnatal loss of methyl-CpG binding protein 2 in the forebrain is sufficient to mediate behavioral aspects of Rett syndrome in mice.
Biological psychiatry 2006;59(5):468-76.
2006: Chang Qiang; Khare Gargi; Dani Vardhan; Nelson Sacha; Jaenisch Rudolf
The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression.
Neuron 2006;49(3):341-8.
2006: Brambrink Tobias; Hochedlinger Konrad; Bell George; Jaenisch Rudolf
ES cells derived from cloned and fertilized blastocysts are transcriptionally and functionally indistinguishable.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(4):933-8.
2006: Beard Caroline; Hochedlinger Konrad; Plath Kathrin; Wutz Anton; Jaenisch Rudolf
Efficient method to generate single-copy transgenic mice by site-specific integration in embryonic stem cells.
Genesis (New York, N.Y. : 2000) 2006;44(1):23-8.
2006: Meissner Alexander; Jaenisch Rudolf
Generation of nuclear transfer-derived pluripotent ES cells from cloned Cdx2-deficient blastocysts.
Nature 2006;439(7073):212-5.
2006: Eminli S; Jaenisch R; Hochedlinger K
Strategies to induce nuclear reprogramming.
Ernst Schering Foundation symposium proceedings 2006;(5):83-98.
2005: Holm Teresa M; Jackson-Grusby Laurie; Brambrink Tobias; Yamada Yasuhiro; Rideout William M; Jaenisch Rudolf
Global loss of imprinting leads to widespread tumorigenesis in adult mice.
Cancer cell 2005;8(4):275-85.
2005: Yamada Yasuhiro; Jackson-Grusby Laurie; Linhart Heinz; Meissner Alex; Eden Amir; Lin Haijiang; Jaenisch Rudolf
Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(38):13580-5.
2005: Boyer Laurie A; Lee Tong Ihn; Cole Megan F; Johnstone Sarah E; Levine Stuart S; Zucker Jacob P; Guenther Matthew G; Kumar Roshan M; Murray Heather L; Jenner Richard G; Gifford David K; Melton Douglas A; Jaenisch Rudolf; Young Richard A
Core transcriptional regulatory circuitry in human embryonic stem cells.
Cell 2005;122(6):947-56.
2005: Dani Vardhan S; Chang Qiang; Maffei Arianna; Turrigiano Gina G; Jaenisch Rudolf; Nelson Sacha B
Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(35):12560-5.
2005: Houbaviy Hristo B; Dennis Lucas; Jaenisch Rudolf; Sharp Phillip A
Characterization of a highly variable eutherian microRNA gene.
RNA (New York, N.Y.) 2005;11(8):1245-57.
2005: Hochedlinger Konrad; Yamada Yasuhiro; Beard Caroline; Jaenisch Rudolf
Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues.
Cell 2005;121(3):465-77.
2005: Ma Yinghong; Jacobs Stephanie B; Jackson-Grusby Laurie; Mastrangelo Mary-Ann; Torres-Betancourt José A; Jaenisch Rudolf; Rasmussen Theodore P
DNA CpG hypomethylation induces heterochromatin reorganization involving the histone variant macroH2A.
Journal of cell science 2005;118(Pt 8):1607-16.
2005: Koralov Sergei B; Novobrantseva Tatiana I; Hochedlinger Konrad; Jaenisch Rudolf; Rajewsky Klaus
Direct in vivo VH to JH rearrangement violating the 12/23 rule.
The Journal of experimental medicine 2005;201(3):341-8.
2005: Lyckman Alvin W; Fan Guoping; Rios Maribel; Jaenisch Rudolf; Sur Mriganka
Normal eye-specific patterning of retinal inputs to murine subcortical visual nuclei in the absence of brain-derived neurotrophic factor.
Visual neuroscience 2005;22(1):27-36.
2005: Gribnau Joost; Luikenhuis Sandra; Hochedlinger Konrad; Monkhorst Kim; Jaenisch Rudolf
X chromosome choice occurs independently of asynchronous replication timing.
The Journal of cell biology 2005;168(3):365-73.
2005: Meissner Alexander; Gnirke Andreas; Bell George W; Ramsahoye Bernard; Lander Eric S; Jaenisch Rudolf
Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis.
Nucleic acids research 2005;33(18):5868-77.
2005: Jaenisch Rudolf; Hochedlinger Konrad; Eggan Kevin
Nuclear cloning, epigenetic reprogramming and cellular differentiation.
Novartis Foundation symposium 2005;265():107-18; discussion 118-28.
2004: Jaenisch Rudolf
Human cloning - the science and ethics of nuclear transplantation.
The New England journal of medicine 2004;351(27):2787-91.
2004: Plath Kathrin; Talbot Dale; Hamer Karien M; Otte Arie P; Yang Thomas P; Jaenisch Rudolf; Panning Barbara
Developmentally regulated alterations in Polycomb repressive complex 1 proteins on the inactive X chromosome.
The Journal of cell biology 2004;167(6):1025-35.
2004: Mihich Enrico; Jaenisch Rudolf
Sixteenth Annual Pezcoller Symposium: stem cells and epigenesis in cancer.
Cancer research 2004;64(22):8474-7.
2004: Wang Zhongde; Jaenisch Rudolf
At most three ES cells contribute to the somatic lineages of chimeric mice and of mice produced by ES-tetraploid complementation.
Developmental biology 2004;275(1):192-201.
2004: Blelloch Robert H; Hochedlinger Konrad; Yamada Yasuhiro; Brennan Cameron; Kim Minjung; Mintz Beatrice; Chin Lynda; Jaenisch Rudolf
Nuclear cloning of embryonal carcinoma cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(39):13985-90.
2004: Begum Nasim A; Kinoshita Kazuo; Kakazu Naoki; Muramatsu Masamichi; Nagaoka Hitoshi; Shinkura Reiko; Biniszkiewicz Detlev; Boyer Laurie A; Jaenisch Rudolf; Honjo Tasuku
Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch.
Science (New York, N.Y.) 2004;305(5687):1160-3.
2004: Hochedlinger Konrad; Blelloch Robert; Brennan Cameron; Yamada Yasuhiro; Kim Minjung; Chin Lynda; Jaenisch Rudolf
Reprogramming of a melanoma genome by nuclear transplantation.
Genes & development 2004;18(15):1875-85.
2004: Ventura Andrea; Meissner Alexander; Dillon Christopher P; McManus Michael; Sharp Phillip A; Van Parijs Luk; Jaenisch Rudolf; Jacks Tyler
Cre-lox-regulated conditional RNA interference from transgenes.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(28):10380-5.
2004: Endres Matthias; Biniszkiewicz Detlev; Sobol Robert W; Harms Christoph; Ahmadi Michael; Lipski Andreas; Katchanov Juri; Mergenthaler Philipp; Dirnagl Ulrich; Wilson Samuel H; Meisel Andreas; Jaenisch Rudolf
Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase.
The Journal of clinical investigation 2004;113(12):1711-21.
2004: Luikenhuis Sandra; Giacometti Emanuela; Beard Caroline F; Jaenisch Rudolf
Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(16):6033-8.
2004: Natoli Thomas A; Alberta Julia A; Bortvin Alex; Taglienti Mary E; Menke Douglas B; Loring Jan; Jaenisch Rudolf; Page David C; Housman David E; Kreidberg Jordan A
Wt1 functions in the development of germ cells in addition to somatic cell lineages of the testis.
Developmental biology 2004;268(2):429-40.
2004: Eggan Kevin; Baldwin Kristin; Tackett Michael; Osborne Joseph; Gogos Joseph; Chess Andrew; Axel Richard; Jaenisch Rudolf
Mice cloned from olfactory sensory neurons.
Nature 2004;428(6978):44-9.
2004: Gaudet F; Rideout W M; Meissner A; Dausman J; Leonhardt H; Jaenisch R
Dnmt1 expression in pre- and postimplantation embryogenesis and the maintenance of IAP silencing.
Molecular and cellular biology 2004;24(4):1640-8.
2004: Jaenisch R; Hochedlinger K; Blelloch R; Yamada Y; Baldwin K; Eggan K
Nuclear cloning, epigenetic reprogramming, and cellular differentiation.
Cold Spring Harbor symposia on quantitative biology 2004;69():19-27.
2004: Hochedlinger Konrad; Rideout William M; Kyba Michael; Daley George Q; Blelloch Robert; Jaenisch Rudolf
Nuclear transplantation, embryonic stem cells and the potential for cell therapy.
The hematology journal : the official journal of the European Haematology Association / EHA 2004;5 Suppl 3():S114-7.
2003: Eggan Kevin; Jaenisch Rudolf
Micromanipulating dosage compensation: understanding X-chromosome inactivation through nuclear transplantation.
Seminars in cell & developmental biology 2003;14(6):349-58.
2003: Chen Wen G; Chang Qiang; Lin Yingxi; Meissner Alexander; West Anne E; Griffith Eric C; Jaenisch Rudolf; Greenberg Michael E
Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2.
Science (New York, N.Y.) 2003;302(5646):885-9.
2003: Hochedlinger Konrad; Jaenisch Rudolf
Nuclear transplantation, embryonic stem cells, and the potential for cell therapy.
The New England journal of medicine 2003;349(3):275-86.
2003: Schwenk Frieder; Zevnik Branko; Brüning Jens; Röhl Mathias; Willuweit Antje; Rode Anja; Hennek Thomas; Kauselmann Gunther; Jaenisch Rudolf; Kühn Ralf
Hybrid embryonic stem cell-derived tetraploid mice show apparently normal morphological, physiological, and neurological characteristics.
Molecular and cellular biology 2003;23(11):3982-9.
2003: Brivanlou Ali H; Gage Fred H; Jaenisch Rudolf; Jessell Thomas; Melton Douglas; Rossant Janet
Stem cells. Setting standards for human embryonic stem cells.
Science (New York, N.Y.) 2003;300(5621):913-6.
2003: Gaudet François; Hodgson J Graeme; Eden Amir; Jackson-Grusby Laurie; Dausman Jessica; Gray Joe W; Leonhardt Heinrich; Jaenisch Rudolf
Induction of tumors in mice by genomic hypomethylation.
Science (New York, N.Y.) 2003;300(5618):489-92.
2003: Eden Amir; Gaudet François; Waghmare Alpana; Jaenisch Rudolf
Chromosomal instability and tumors promoted by DNA hypomethylation.
Science (New York, N.Y.) 2003;300(5618):455.
2003: Bortvin Alex; Eggan Kevin; Skaletsky Helen; Akutsu Hidenori; Berry Deborah L; Yanagimachi Ryuzo; Page David C; Jaenisch Rudolf
Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.
Development (Cambridge, England) 2003;130(8):1673-80.
2003: Gribnau Joost; Hochedlinger Konrad; Hata Ken; Li En; Jaenisch Rudolf
Asynchronous replication timing of imprinted loci is independent of DNA methylation, but consistent with differential subnuclear localization.
Genes & development 2003;17(6):759-73.
2003: Cramer Thorsten; Yamanishi Yuji; Clausen Björn E; Förster Irmgard; Pawlinski Rafal; Mackman Nigel; Haase Volker H; Jaenisch Rudolf; Corr Maripat; Nizet Victor; Firestein Gary S; Gerber Hans Peter; Ferrara Napoleone; Johnson Randall S
HIF-1alpha is essential for myeloid cell-mediated inflammation.
Cell 2003;112(5):645-57.
2003: Jaenisch Rudolf; Bird Adrian
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals.
Nature genetics 2003;33 Suppl():245-54.
2003: Seibler Jost; Zevnik Branko; Küter-Luks Birgit; Andreas Susanne; Kern Heidrun; Hennek Thomas; Rode Anja; Heimann Cornelia; Faust Nicole; Kauselmann Gunther; Schoor Michael; Jaenisch Rudolf; Rajewsky Klaus; Kühn Ralf; Schwenk Frieder
Rapid generation of inducible mouse mutants.
Nucleic acids research 2003;31(4):e12.
2003: Endres Matthias; Fan Guoping; Hirt Lorenz; Jaenisch Rudolf
Stroke damage in mice after knocking the neutrophin-4 gene into the brain-derived neurotrophic factor locus.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2003;23(2):150-3.
2003: Eggan Kevin; Jaenisch Rudolf
Differentiation of F1 embryonic stem cells into viable male and female mice by tetraploid embryo complementation.
Methods in enzymology 2003;365():25-39.
2002: Hochedlinger Konrad; Jaenisch Rudolf
Nuclear transplantation: lessons from frogs and mice.
Current opinion in cell biology 2002;14(6):741-8.
2002: McCarrey John R; Watson Cathy; Atencio Julia; Ostermeier G Charles; Marahrens York; Jaenisch Rudolf; Krawetz Stephen A
X-chromosome inactivation during spermatogenesis is regulated by an Xist/Tsix-independent mechanism in the mouse.
Genesis (New York, N.Y. : 2000) 2002;34(4):257-66.
2002: Tudor Matthew; Akbarian Schahram; Chen Richard Z; Jaenisch Rudolf
Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(24):15536-41.
2002: Turner James M A; Mahadevaiah Shantha K; Elliott David J; Garchon Henri-Jean; Pehrson John R; Jaenisch Rudolf; Burgoyne Paul S
Meiotic sex chromosome inactivation in male mice with targeted disruptions of Xist.
Journal of cell science 2002;115(Pt 21):4097-105.
2002: Humpherys David; Eggan Kevin; Akutsu Hidenori; Friedman Adam; Hochedlinger Konrad; Yanagimachi Ryuzo; Lander Eric S; Golub Todd R; Jaenisch Rudolf
Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(20):12889-94.
2002: Akbarian Schahram; Rios Maribel; Liu Rong-Jian; Gold Stephen J; Fong Hiu-Fai; Zeiler Steve; Coppola Vincenzo; Tessarollo Lino; Jones Kevin R; Nestler Eric J; Aghajanian George K; Jaenisch Rudolf
Brain-derived neurotrophic factor is essential for opiate-induced plasticity of noradrenergic neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(10):4153-62.
2002: Eggan Kevin; Rode Anja; Jentsch Isabell; Samuel Caroline; Hennek Thomas; Tintrup Hartmut; Zevnik Branko; Erwin Jennifer; Loring Janet; Jackson-Grusby Laurie; Speicher Michael R; Kuehn Ralf; Jaenisch Rudolf
Male and female mice derived from the same embryonic stem cell clone by tetraploid embryo complementation.
Nature biotechnology 2002;20(5):455-9.
2002: Rideout William M; Hochedlinger Konrad; Kyba Michael; Daley George Q; Jaenisch Rudolf
Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy.
Cell 2002;109(1):17-27.
2002: Biniszkiewicz Detlev; Gribnau Joost; Ramsahoye Bernard; Gaudet François; Eggan Kevin; Humpherys David; Mastrangelo Mary-Ann; Jun Zhan; Walter Jörn; Jaenisch Rudolf
Dnmt1 overexpression causes genomic hypermethylation, loss of imprinting, and embryonic lethality.
Molecular and cellular biology 2002;22(7):2124-35.
2002: Hochedlinger Konrad; Jaenisch Rudolf
Monoclonal mice generated by nuclear transfer from mature B and T donor cells.
Nature 2002;415(6875):1035-8.
2002: Possemato Richard; Eggan Kevin; Moeller Benjamin J; Jaenisch Rudolf; Jackson-Grusby Laurie
Flp recombinase regulated lacZ expression at the ROSA26 locus.
Genesis (New York, N.Y. : 2000) 2002;32(2):184-6.
2002: Bates Brian; Hirt Lorenz; Thomas Sunu S; Akbarian Schahram; Le Dean; Amin-Hanjani Sepideh; Whalen Michael; Jaenisch Rudolf; Moskowitz Michael A
Neurotrophin-3 promotes cell death induced in cerebral ischemia, oxygen-glucose deprivation, and oxidative stress: possible involvement of oxygen free radicals.
Neurobiology of disease 2002;9(1):24-37.
2002: Wutz Anton; Rasmussen Theodore P; Jaenisch Rudolf
Chromosomal silencing and localization are mediated by different domains of Xist RNA.
Nature genetics 2002;30(2):167-74.
2002: Jaenisch Rudolf
Nuclear cloning, embryonic stem cells, and transplantation therapy.
Harvey lectures 2002;98():145-71.
2001: Luikenhuis S; Wutz A; Jaenisch R
Antisense transcription through the Xist locus mediates Tsix function in embryonic stem cells.
Molecular and cellular biology 2001;21(24):8512-20.
2001: Rasmussen T P; Wutz A P; Pehrson J R; Jaenisch R R
Expression of Xist RNA is sufficient to initiate macrochromatin body formation.
Chromosoma 2001;110(6):411-20.
2001: Akbarian S; Chen R Z; Gribnau J; Rasmussen T P; Fong H; Jaenisch R; Jones E G
Expression pattern of the Rett syndrome gene MeCP2 in primate prefrontal cortex.
Neurobiology of disease 2001;8(5):784-91.
2001: Rios M; Fan G; Fekete C; Kelly J; Bates B; Kuehn R; Lechan R M; Jaenisch R
Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity.
Molecular endocrinology (Baltimore, Md.) 2001;15(10):1748-57.
2001: Akbarian S; Bates B; Liu R J; Skirboll S L; Pejchal T; Coppola V; Sun L D; Fan G; Kucera J; Wilson M A; Tessarollo L; Kosofsky B E; Taylor J R; Bothwell M; Nestler E J; Aghajanian G K; Jaenisch R
Neurotrophin-3 modulates noradrenergic neuron function and opiate withdrawal.
Molecular psychiatry 2001;6(5):593-604.
2001: Rideout W M; Eggan K; Jaenisch R
Nuclear cloning and epigenetic reprogramming of the genome.
Science (New York, N.Y.) 2001;293(5532):1093-8.
2001: Humpherys D; Eggan K; Akutsu H; Hochedlinger K; Rideout W M; Biniszkiewicz D; Yanagimachi R; Jaenisch R
Epigenetic instability in ES cells and cloned mice.
Science (New York, N.Y.) 2001;293(5527):95-7.
2001: Csankovszki G; Nagy A; Jaenisch R
Synergism of Xist RNA, DNA methylation, and histone hypoacetylation in maintaining X chromosome inactivation.
The Journal of cell biology 2001;153(4):773-84.
2001: Eggan K; Akutsu H; Loring J; Jackson-Grusby L; Klemm M; Rideout W M; Yanagimachi R; Jaenisch R
Hybrid vigor, fetal overgrowth, and viability of mice derived by nuclear cloning and tetraploid embryo complementation.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(11):6209-14.
2001: Wutz A; Theussl H C; Dausman J; Jaenisch R; Barlow D P; Wagner E F
Non-imprinted Igf2r expression decreases growth and rescues the Tme mutation in mice.
Development (Cambridge, England) 2001;128(10):1881-7.
2001: Jaenisch R; Wilmut I
Developmental biology. Don't clone humans!
Science (New York, N.Y.) 2001;291(5513):2552.
2001: Chen R Z; Akbarian S; Tudor M; Jaenisch R
Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice.
Nature genetics 2001;27(3):327-31.
2001: Haase V H; Glickman J N; Socolovsky M; Jaenisch R
Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1583-8.
2001: Fan G; Beard C; Chen R Z; Csankovszki G; Sun Y; Siniaia M; Biniszkiewicz D; Bates B; Lee P P; Kuhn R; Trumpp A; Poon C; Wilson C B; Jaenisch R
DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(3):788-97.
2001: Jackson-Grusby L; Beard C; Possemato R; Tudor M; Fambrough D; Csankovszki G; Dausman J; Lee P; Wilson C; Lander E; Jaenisch R
Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation.
Nature genetics 2001;27(1):31-9.
2001: Fan G; Siniaia M; Poon C S; Jaenisch R
Effect of DNA hypomethylation on neural control of respiration: a genetic model.
Advances in experimental medicine and biology 2001;499():195-200.
2000: Lyko F; Ramsahoye B H; Jaenisch R
DNA methylation in Drosophila melanogaster.
Nature 2000;408(6812):538-40.
2000: Eggan K; Akutsu H; Hochedlinger K; Rideout W; Yanagimachi R; Jaenisch R
X-Chromosome inactivation in cloned mouse embryos.
Science (New York, N.Y.) 2000;290(5496):1578-81.
2000: Cherry S R; Biniszkiewicz D; van Parijs L; Baltimore D; Jaenisch R
Retroviral expression in embryonic stem cells and hematopoietic stem cells.
Molecular and cellular biology 2000;20(20):7419-26.
2000: Rasmussen T P; Mastrangelo M A; Eden A; Pehrson J R; Jaenisch R
Dynamic relocalization of histone MacroH2A1 from centrosomes to inactive X chromosomes during X inactivation.
The Journal of cell biology 2000;150(5):1189-98.
2000: Lyko F; Whittaker A J; Orr-Weaver T L; Jaenisch R
The putative Drosophila methyltransferase gene dDnmt2 is contained in a transposon-like element and is expressed specifically in ovaries.
Mechanisms of development 2000;95(1-2):215-7.
2000: Fan G; Copray S; Huang E J; Jones K; Yan Q; Walro J; Jaenisch R; Kucera J
Formation of a full complement of cranial proprioceptors requires multiple neurotrophins.
Developmental dynamics : an official publication of the American Association of Anatomists 2000;218(2):359-70.
2000: Ramsahoye B H; Biniszkiewicz D; Lyko F; Clark V; Bird A P; Jaenisch R
Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5237-42.
2000: Endres M; Meisel A; Biniszkiewicz D; Namura S; Prass K; Ruscher K; Lipski A; Jaenisch R; Moskowitz M A; Dirnagl U
DNA methyltransferase contributes to delayed ischemic brain injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(9):3175-81.
2000: Lombard D B; Beard C; Johnson B; Marciniak R A; Dausman J; Bronson R; Buhlmann J E; Lipman R; Curry R; Sharpe A; Jaenisch R; Guarente L
Mutations in the WRN gene in mice accelerate mortality in a p53-null background.
Molecular and cellular biology 2000;20(9):3286-91.
2000: Wutz A; Jaenisch R
A shift from reversible to irreversible X inactivation is triggered during ES cell differentiation.
Molecular cell 2000;5(4):695-705.
2000: Fan G; Egles C; Sun Y; Minichiello L; Renger J J; Klein R; Liu G; Jaenisch R
Knocking the NT4 gene into the BDNF locus rescues BDNF deficient mice and reveals distinct NT4 and BDNF activities.
Nature neuroscience 2000;3(4):350-7.
2000: Johnson F B; Lombard D B; Neff N F; Mastrangelo M A; Dewolf W; Ellis N A; Marciniak R A; Yin Y; Jaenisch R; Guarente L
Association of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cells.
Cancer research 2000;60(5):1162-7.
2000: Rideout W M; Wakayama T; Wutz A; Eggan K; Jackson-Grusby L; Dausman J; Yanagimachi R; Jaenisch R
Generation of mice from wild-type and targeted ES cells by nuclear cloning.
Nature genetics 2000;24(2):109-10.
2000: Endres M; Fan G; Hirt L; Fujii M; Matsushita K; Liu X; Jaenisch R; Moskowitz M A
Ischemic brain damage in mice after selectively modifying BDNF or NT4 gene expression.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2000;20(1):139-44.
1999: Lyko F; Ramsahoye B H; Kashevsky H; Tudor M; Mastrangelo M A; Orr-Weaver T L; Jaenisch R
Mammalian (cytosine-5) methyltransferases cause genomic DNA methylation and lethality in Drosophila.
Nature genetics 1999;23(3):363-6.
1999: Tudor M; Murray P J; Onufryk C; Jaenisch R; Young R A
Ubiquitous expression and embryonic requirement for RNA polymerase II coactivator subunit Srb7 in mice.
Genes & development 1999;13(18):2365-8.
1999: Rasmussen T P; Huang T; Mastrangelo M A; Loring J; Panning B; Jaenisch R
Messenger RNAs encoding mouse histone macroH2A1 isoforms are expressed at similar levels in male and female cells and result from alternative splicing.
Nucleic acids research 1999;27(18):3685-9.
1999: Sidow A; Bulotsky M S; Kerrebrock A W; Birren B W; Altshuler D; Jaenisch R; Johnson K R; Lander E S
A novel member of the F-box/WD40 gene family, encoding dactylin, is disrupted in the mouse dactylaplasia mutant.
Nature genetics 1999;23(1):104-7.
1999: Csankovszki G; Panning B; Bates B; Pehrson J R; Jaenisch R
Conditional deletion of Xist disrupts histone macroH2A localization but not maintenance of X inactivation.
Nature genetics 1999;22(4):323-4.
1999: Fan G; Jaenisch R; Kucera J
A role for p75 receptor in neurotrophin-3 functioning during the development of limb proprioception.
Neuroscience 1999;90(1):259-68.
1999: Bates B; Rios M; Trumpp A; Chen C; Fan G; Bishop J M; Jaenisch R
Neurotrophin-3 is required for proper cerebellar development.
Nature neuroscience 1999;2(2):115-7.
1999: Donovan M J; Natoli T A; Sainio K; Amstutz A; Jaenisch R; Sariola H; Kreidberg J A
Initial differentiation of the metanephric mesenchyme is independent of WT1 and the ureteric bud.
Developmental genetics 1999;24(3-4):252-62.
1998: Gaudet F; Talbot D; Leonhardt H; Jaenisch R
A short DNA methyltransferase isoform restores methylation in vivo.
The Journal of biological chemistry 1998;273(49):32725-9.
1998: Chen R Z; Pettersson U; Beard C; Jackson-Grusby L; Jaenisch R
DNA hypomethylation leads to elevated mutation rates.
Nature 1998;395(6697):89-93.
1998: Hormuzdi S G; Penttinen R; Jaenisch R; Bornstein P
A gene-targeting approach identifies a function for the first intron in expression of the alpha1(I) collagen gene.
Molecular and cellular biology 1998;18(6):3368-75.
1998: Panning B; Jaenisch R
RNA and the epigenetic regulation of X chromosome inactivation.
Cell 1998;93(3):305-8.
1998: Kucera J; Fan G; Walro J; Copray S; Tessarollo L; Jaenisch R
Neurotrophin-3 and trkC in muscle are non-essential for the development of mouse muscle spindles.
Neuroreport 1998;9(5):905-9.
1998: Marahrens Y; Loring J; Jaenisch R
Role of the Xist gene in X chromosome choosing.
Cell 1998;92(5):657-64.
1998: Jaenisch R; Beard C; Lee J; Marahrens Y; Panning B
Mammalian X chromosome inactivation.
Novartis Foundation symposium 1998;214():200-9; discussion 209-13, 228-32.
1997: Sidow A; Bulotsky M S; Kerrebrock A W; Bronson R T; Daly M J; Reeve M P; Hawkins T L; Birren B W; Jaenisch R; Lander E S
Serrate2 is disrupted in the mouse limb-development mutant syndactylism.
Nature 1997;389(6652):722-5.
1997: Panning B; Dausman J; Jaenisch R
X chromosome inactivation is mediated by Xist RNA stabilization.
Cell 1997;90(5):907-16.
1997: Tucker K L; Wang Y; Dausman J; Jaenisch R
A transgenic mouse strain expressing four drug-selectable marker genes.
Nucleic acids research 1997;25(18):3745-6.
1997: Jaenisch R
DNA methylation and imprinting: why bother?
Trends in genetics : TIG 1997;13(8):323-9.
1997: Wang Y; Jaenisch R
Myogenin can substitute for Myf5 in promoting myogenesis but less efficiently.
Development (Cambridge, England) 1997;124(13):2507-13.
1997: Luoh S W; Bain P A; Polakiewicz R D; Goodheart M L; Gardner H; Jaenisch R; Page D C
Zfx mutation results in small animal size and reduced germ cell number in male and female mice.
Development (Cambridge, England) 1997;124(11):2275-84.
1997: DiPersio C M; Hodivala-Dilke K M; Jaenisch R; Kreidberg J A; Hynes R O
alpha3beta1 Integrin is required for normal development of the epidermal basement membrane.
The Journal of cell biology 1997;137(3):729-42.
1997: Liu X; Wu H; Loring J; Hormuzdi S; Disteche C M; Bornstein P; Jaenisch R
Trisomy eight in ES cells is a common potential problem in gene targeting and interferes with germ line transmission.
Developmental dynamics : an official publication of the American Association of Anatomists 1997;209(1):85-91.
1997: Lee J T; Jaenisch R
The (epi)genetic control of mammalian X-chromosome inactivation.
Current opinion in genetics & development 1997;7(2):274-80.
1997: Jackson-Grusby L; Laird P W; Magge S N; Moeller B J; Jaenisch R
Mutagenicity of 5-aza-2'-deoxycytidine is mediated by the mammalian DNA methyltransferase.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(9):4681-5.
1997: Lee J T; Jaenisch R
Long-range cis effects of ectopic X-inactivation centres on a mouse autosome.
Nature 1997;386(6622):275-9.
1997: Liu X; Wu H; Byrne M; Krane S; Jaenisch R
Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(5):1852-6.
1997: Marahrens Y; Panning B; Dausman J; Strauss W; Jaenisch R
Xist-deficient mice are defective in dosage compensation but not spermatogenesis.
Genes & development 1997;11(2):156-66.
1996: Lee J T; Jaenisch R
A method for high efficiency YAC lipofection into murine embryonic stem cells.
Nucleic acids research 1996;24(24):5054-5.
1996: Soloway P D; Alexander C M; Werb Z; Jaenisch R
Targeted mutagenesis of Timp-1 reveals that lung tumor invasion is influenced by Timp-1 genotype of the tumor but not by that of the host.
Oncogene 1996;13(11):2307-14.
1996: Tucker K L; Talbot D; Lee M A; Leonhardt H; Jaenisch R
Complementation of methylation deficiency in embryonic stem cells by a DNA methyltransferase minigene.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(23):12920-5.
1996: Krane S M; Byrne M H; Lemaître V; Henriet P; Jeffrey J J; Witter J P; Liu X; Wu H; Jaenisch R; Eeckhout Y
Different collagenase gene products have different roles in degradation of type I collagen.
The Journal of biological chemistry 1996;271(45):28509-15.
1996: Jackson-Grusby L; Jaenisch R
Experimental manipulation of genomic methylation.
Seminars in cancer biology 1996;7(5):261-8.
1996: Harbers K; Müller U; Grams A; Li E; Jaenisch R; Franz T
Provirus integration into a gene encoding a ubiquitin-conjugating enzyme results in a placental defect and embryonic lethality.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(22):12412-7.
1996: Panning B; Jaenisch R
DNA hypomethylation can activate Xist expression and silence X-linked genes.
Genes & development 1996;10(16):1991-2002.
1996: Lee J T; Strauss W M; Dausman J A; Jaenisch R
A 450 kb transgene displays properties of the mammalian X-inactivation center.
Cell 1996;86(1):83-94.
1996: Gardner H; Kreidberg J; Koteliansky V; Jaenisch R
Deletion of integrin alpha 1 by homologous recombination permits normal murine development but gives rise to a specific deficit in cell adhesion.
Developmental biology 1996;175(2):301-13.
1996: Schorle H; Meier P; Buchert M; Jaenisch R; Mitchell P J
Transcription factor AP-2 essential for cranial closure and craniofacial development.
Nature 1996;381(6579):235-8.
1996: Chun J; Jaenisch R
Clonal cell lines produced by infection of neocortical neuroblasts using multiple oncogenes transduced by retroviruses.
Molecular and cellular neurosciences 1996;7(4):304-21.
1996: Tucker K L; Beard C; Dausmann J; Jackson-Grusby L; Laird P W; Lei H; Li E; Jaenisch R
Germ-line passage is required for establishment of methylation and expression patterns of imprinted but not of nonimprinted genes.
Genes & development 1996;10(8):1008-20.
1996: Wang Y; Schnegelsberg P N; Dausman J; Jaenisch R
Functional redundancy of the muscle-specific transcription factors Myf5 and myogenin.
Nature 1996;379(6568):823-5.
1995: Ernfors P; Kucera J; Lee K F; Loring J; Jaenisch R
Studies on the physiological role of brain-derived neurotrophic factor and neurotrophin-3 in knockout mice.
The International journal of developmental biology 1995;39(5):799-807.
1995: Beard C; Li E; Jaenisch R
Loss of methylation activates Xist in somatic but not in embryonic cells.
Genes & development 1995;9(19):2325-34.
1995: Wu H; Liu X; Jaenisch R; Lodish H F
Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor.
Cell 1995;83(1):59-67.
1995: Liu X; Wu H; Byrne M; Jeffrey J; Krane S; Jaenisch R
A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodeling.
The Journal of cell biology 1995;130(1):227-37.
1995: Ernfors P; Van De Water T; Loring J; Jaenisch R
Complementary roles of BDNF and NT-3 in vestibular and auditory development.
Neuron 1995;14(6):1153-64.
1995: Liu X; Ernfors P; Wu H; Jaenisch R
Sensory but not motor neuron deficits in mice lacking NT4 and BDNF.
Nature 1995;375(6528):238-41.
1995: Laird P W; Jackson-Grusby L; Fazeli A; Dickinson S L; Jung W E; Li E; Weinberg R A; Jaenisch R
Suppression of intestinal neoplasia by DNA hypomethylation.
Cell 1995;81(2):197-205.
1994: Jüttermann R; Li E; Jaenisch R
Toxicity of 5-aza-2'-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(25):11797-801.
1994: Fässler R; Schnegelsberg P N; Dausman J; Shinya T; Muragaki Y; McCarthy M T; Olsen B R; Jaenisch R
Mice lacking alpha 1 (IX) collagen develop noninflammatory degenerative joint disease.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(11):5070-4.
1994: Ernfors P; Lee K F; Kucera J; Jaenisch R
Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents.
Cell 1994;77(4):503-12.
1994: Lee K F; Davies A M; Jaenisch R
p75-deficient embryonic dorsal root sensory and neonatal sympathetic neurons display a decreased sensitivity to NGF.
Development (Cambridge, England) 1994;120(4):1027-33.
1994: Wu H; Liu X; Jaenisch R
Double replacement: strategy for efficient introduction of subtle mutations into the murine Col1a-1 gene by homologous recombination in embryonic stem cells.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(7):2819-23.
1994: Ernfors P; Lee K F; Jaenisch R
Mice lacking brain-derived neurotrophic factor develop with sensory deficits.
Nature 1994;368(6467):147-50.
1994: Lee K F; Bachman K; Landis S; Jaenisch R
Dependence on p75 for innervation of some sympathetic targets.
Science (New York, N.Y.) 1994;263(5152):1447-9.
1994: Vassalli A; Matzuk M M; Gardner H A; Lee K F; Jaenisch R
Activin/inhibin beta B subunit gene disruption leads to defects in eyelid development and female reproduction.
Genes & development 1994;8(4):414-27.
1994: Ernfors P; Lee K F; Jaenisch R
Target derived and putative local actions of neurotrophins in the peripheral nervous system.
Progress in brain research 1994;103():43-54.
1994: Laird P W; Jaenisch R
DNA methylation and cancer.
Human molecular genetics 1994;3 Spec No():1487-95.
1993: Fenton S P; Lamande S R; Hannagan M; Stacey A; Jaenisch R; Bateman J F
Genomic sequence of mouse COL1A1 encoding the collagen propeptides.
Biochimica et biophysica acta 1993;1216(3):469-74.
1993: Li E; Beard C; Jaenisch R
Role for DNA methylation in genomic imprinting.
Nature 1993;366(6453):362-5.
1993: Grusby M J; Auchincloss H; Lee R; Johnson R S; Spencer J P; Zijlstra M; Jaenisch R; Papaioannou V E; Glimcher L H
Mice lacking major histocompatibility complex class I and class II molecules.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(9):3913-7.
1993: Strauss W M; Dausman J; Beard C; Johnson C; Lawrence J B; Jaenisch R
Germ line transmission of a yeast artificial chromosome spanning the murine alpha 1(I) collagen locus.
Science (New York, N.Y.) 1993;259(5103):1904-7.
1993: Li E; Sucov H M; Lee K F; Evans R M; Jaenisch R
Normal development and growth of mice carrying a targeted disruption of the alpha 1 retinoic acid receptor gene.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(4):1590-4.
1993: Sharpe A H; Jaenisch R
Retroviral spongiform degenerative disease produced by the murine neurotropic retrovirus Cas-Br-E.
Developments in biological standardization 1993;80():45-52.
1992: Wu H; Fässler R; Schnieke A; Barker D; Lee K H; Chapman V; Francke U; Jaenisch R
An X-linked human collagen transgene escapes X inactivation in a subset of cells.
Development (Cambridge, England) 1992;116(3):687-95.
1992: Rudnicki M A; Braun T; Hinuma S; Jaenisch R
Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development.
Cell 1992;71(3):383-90.
1992: Sanjuan N; Zijlstra M; Carroll J; Jaenisch R; Benjamin T
Infection by polyomavirus of murine cells deficient in class I major histocompatibility complex expression.
Journal of virology 1992;66(7):4587-90.
1992: Li E; Bestor T H; Jaenisch R
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.
Cell 1992;69(6):915-26.
1992: Lee K F; Li E; Huber L J; Landis S C; Sharpe A H; Chao M V; Jaenisch R
Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system.
Cell 1992;69(5):737-49.
1992: Zijlstra M; Auchincloss H; Loring J M; Chase C M; Russell P S; Jaenisch R
Skin graft rejection by beta 2-microglobulin-deficient mice.
The Journal of experimental medicine 1992;175(4):885-93.
1992: Strauss W M; Jaenisch R
Molecular complementation of a collagen mutation in mammalian cells using yeast artificial chromosomes.
The EMBO journal 1992;11(2):417-22.
1992: Pereira P; Zijlstra M; McMaster J; Loring J M; Jaenisch R; Tonegawa S
Blockade of transgenic gamma delta T cell development in beta 2-microglobulin deficient mice.
The EMBO journal 1992;11(1):25-31.
1992: Correa I; Bix M; Liao N S; Zijlstra M; Jaenisch R; Raulet D
Most gamma delta T cells develop normally in beta 2-microglobulin-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(2):653-7.
1992: Krane S M; Jaenisch R
Site-directed mutagenesis of type I collagen: effect on susceptibility to collagenase.
Matrix (Stuttgart, Germany). Supplement 1992;1():64-7.
1992: Strauss W M; Jaenisch E; Jaenisch R
A strategy for rapid production and screening of yeast artificial chromosome libraries.
Mammalian genome : official journal of the International Mammalian Genome Society 1992;2(3):150-7.
1991: Barker D D; Wu H; Hartung S; Breindl M; Jaenisch R
Retrovirus-induced insertional mutagenesis: mechanism of collagen mutation in Mov13 mice.
Molecular and cellular biology 1991;11(10):5154-63.
1991: Huszar D; Sharpe A; Hashmi S; Bouchard B; Houghton A; Jaenisch R
Generation of pigmented stripes in albino mice by retroviral marking of neural crest melanoblasts.
Development (Cambridge, England) 1991;113(2):653-60.
1991: Liao N S; Bix M; Zijlstra M; Jaenisch R; Raulet D
MHC class I deficiency: susceptibility to natural killer (NK) cells and impaired NK activity.
Science (New York, N.Y.) 1991;253(5016):199-202.
1991: Choi T; Huang M; Gorman C; Jaenisch R
A generic intron increases gene expression in transgenic mice.
Molecular and cellular biology 1991;11(6):3070-4.
1991: Huszar D; Sharpe A; Jaenisch R
Migration and proliferation of cultured neural crest cells in W mutant neural crest chimeras.
Development (Cambridge, England) 1991;112(1):131-41.
1991: Raulet D H; Spencer D M; Hsiang Y H; Goldman J P; Bix M; Liao N S; Zijstra M; Jaenisch R; Correa I
Control of gamma delta T-cell development.
Immunological reviews 1991;120():185-204.
1991: Bix M; Liao N S; Zijlstra M; Loring J; Jaenisch R; Raulet D
Rejection of class I MHC-deficient haemopoietic cells by irradiated MHC-matched mice.
Nature 1991;349(6307):329-31.
1991: Chun J J; Schatz D G; Oettinger M A; Jaenisch R; Baltimore D
The recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system.
Cell 1991;64(1):189-200.
1990: Wu H; Byrne M H; Stacey A; Goldring M B; Birkhead J R; Jaenisch R; Krane S M
Generation of collagenase-resistant collagen by site-directed mutagenesis of murine pro alpha 1(I) collagen gene.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(15):5888-92.
1990: Weiher H; Noda T; Gray D A; Sharpe A H; Jaenisch R
Transgenic mouse model of kidney disease: insertional inactivation of ubiquitously expressed gene leads to nephrotic syndrome.
Cell 1990;62(3):425-34.
1990: Sharpe A H; Hunter J J; Chassler P; Jaenisch R
Role of abortive retroviral infection of neurons in spongiform CNS degeneration.
Nature 1990;346(6280):181-3.
1990: Gridley T; Gray D A; Orr-Weaver T; Soriano P; Barton D E; Francke U; Jaenisch R
Molecular analysis of the Mov 34 mutation: transcript disrupted by proviral integration in mice is conserved in Drosophila.
Development (Cambridge, England) 1990;109(1):235-42.
1990: Zijlstra M; Bix M; Simister N E; Loring J M; Raulet D H; Jaenisch R
Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells.
Nature 1990;344(6268):742-6.
1990: Bateman J F; Mascara T; Cole W G; Stacey A; Jaenisch R
The study of collagen structure and function by site-directed mutagenesis of collagen genes.
Annals of the New York Academy of Sciences 1990;580():324-9.
1990: Harbers K; Francke U; Soriano P; Jaenisch R; Müller U
Structure and chromosomal mapping of a highly polymorphic repetitive DNA sequence from the pseudoautosomal region of the mouse sex chromosomes.
Cytogenetics and cell genetics 1990;53(2-3):129-33.
1989: Stuhlmann H; Jaenisch R; Mulligan R C
Transfer of a mutant dihydrofolate reductase gene into pre- and postimplantation mouse embryos by a replication-competent retrovirus vector.
Journal of virology 1989;63(11):4857-65.
1989: Zijlstra M; Li E; Sajjadi F; Subramani S; Jaenisch R
Germ-line transmission of a disrupted beta 2-microglobulin gene produced by homologous recombination in embryonic stem cells.
Nature 1989;342(6248):435-8.
1989: Compere S J; Baldacci P; Sharpe A H; Thompson T; Land H; Jaenisch R
The ras and myc oncogenes cooperate in tumor induction in many tissues when introduced into midgestation mouse embryos by retroviral vectors.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(7):2224-8.
1989: Sharpe A H; Hunter J J; Ruprecht R M; Jaenisch R
Maternal transmission of retroviral disease and strategies for preventing infection of the neonate.
Journal of virology 1989;63(3):1049-53.
1989: Stuhlmann H; Jaenisch R; Mulligan R C
Construction and properties of replication-competent murine retroviral vectors encoding methotrexate resistance.
Molecular and cellular biology 1989;9(1):100-8.
1989: Cole W G; Jaenisch R; Bateman J F
New insights into the molecular pathology of osteogenesis imperfecta.
The Quarterly journal of medicine 1989;70(261):1-4.
1989: Compere S J; Baldacci P A; Sharpe A H; Jaenisch R
Retroviral transduction of the human c-Ha-ras-1 oncogene into midgestation mouse embryos promotes rapid epithelial hyperplasia.
Molecular and cellular biology 1989;9(1):6-14.
1989: Bateman J F; Mascara T; Cole W G; Stacey A; Jaenisch R
Collagen protein abnormalities produced by site-directed mutagenesis of the pro alpha 1(I) gene.
Connective tissue research 1989;20(1-4):205-12; discussion 261-3.
1988: Sharpe A H; Hunter J J; Ruprecht R M; Jaenisch R
Maternal transmission of retroviral disease: transgenic mice as a rapid test system for evaluating perinatal and transplacental antiretroviral therapy.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(24):9792-6.
1988: Compere S J; Baldacci P; Jaenisch R
Oncogenes in transgenic mice.
Biochimica et biophysica acta 1988;948(2):129-49.
1988: Jaenisch R
Transgenic animals.
Science (New York, N.Y.) 1988;240(4858):1468-74.
1988: Stacey A; Bateman J; Choi T; Mascara T; Cole W; Jaenisch R
Perinatal lethal osteogenesis imperfecta in transgenic mice bearing an engineered mutant pro-alpha 1(I) collagen gene.
Nature 1988;332(6160):131-6.
1987: Berleth T; Nobis P; Jaenisch R; Harbers K
Activation of endogenous retroviral genomes in Mov strains of mice.
The Journal of general virology 1987;68 ( Pt 11)():2919-23.
1987: Soriano P; Keitges E A; Schorderet D F; Harbers K; Gartler S M; Jaenisch R
High rate of recombination and double crossovers in the mouse pseudoautosomal region during male meiosis.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(20):7218-20.
1987: Soriano P; Gridley T; Jaenisch R
Retroviruses and insertional mutagenesis in mice: proviral integration at the Mov 34 locus leads to early embryonic death.
Genes & development 1987;1(4):366-75.
1987: Schnieke A; Dziadek M; Bateman J; Mascara T; Harbers K; Gelinas R; Jaenisch R
Introduction of the human pro alpha 1(I) collagen gene into pro alpha 1(I)-deficient Mov-13 mouse cells leads to formation of functional mouse-human hybrid type I collagen.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(3):764-8.
1986: Hartung S; Jaenisch R; Breindl M
Retrovirus insertion inactivates mouse alpha 1(I) collagen gene by blocking initiation of transcription.
Nature 1986;320(6060):365-7.
1986: Jaenisch R; Soriano P
Retroviruses as tools for mammalian development.
Symposium on Fundamental Cancer Research 1986;39():59-65.
1985: Jaenisch R; Schnieke A; Harbers K
Treatment of mice with 5-azacytidine efficiently activates silent retroviral genomes in different tissues.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(5):1451-5.
1985: Jaenisch R; Breindl M; Harbers K; Jähner D; Löhler J
Retroviruses and insertional mutagenesis.
Cold Spring Harbor symposia on quantitative biology 1985;50():439-45.
1984: Breindl M; Harbers K; Jaenisch R
Retrovirus-induced lethal mutation in collagen I gene of mice is associated with an altered chromatin structure.
Cell 1984;38(1):9-16.
1983: Stewart C; Harbers K; Jähner D; Jaenisch R
X chromosome-linked transmission and expression of retroviral genomes microinjected into mouse zygotes.
Science (New York, N.Y.) 1983;221(4612):760-2.
1983: Schnieke A; Harbers K; Jaenisch R
Embryonic lethal mutation in mice induced by retrovirus insertion into the alpha 1(I) collagen gene.
Nature 1983;304(5924):315-20.
1983: Simon D; Stuhlmann H; Jähner D; Wagner H; Werner E; Jaenisch R
Retrovirus genomes methylated by mammalian but not bacterial methylase are non-infectious.
Nature 1983;304(5923):275-7.
1983: Schnieke A; Stuhlmann H; Harbers K; Chumakov I; Jaenisch R
Endogenous Moloney leukemia virus in nonviremic Mov substrains of mice carries defects in the proviral genome.
Journal of virology 1983;45(2):505-13.
1983: Jaenisch R; Harbers K; Schnieke A; Löhler J; Chumakov I; Jähner D; Grotkopp D; Hoffmann E
Germline integration of moloney murine leukemia virus at the Mov13 locus leads to recessive lethal mutation and early embryonic death.
Cell 1983;32(1):209-16.
1983: Jaenisch R; Harbers K; Jähner D; Stewart C; Stuhlmann H
Expression of retroviruses during early mouse embryogenesis.
Haematology and blood transfusion 1983;28():270-4.
1983: Jähner D; Stewart C L; Stuhlmann H; Harbers K; Jaenisch R
Retroviruses and embryogenesis: de novo methylation activity involved in gene expression.
Cold Spring Harbor symposia on quantitative biology 1983;47 Pt 2():611-9.
1982: Jähner D; Stuhlmann H; Stewart C L; Harbers K; Löhler J; Simon I; Jaenisch R
De novo methylation and expression of retroviral genomes during mouse embryogenesis.
Nature 1982;298(5875):623-8.
1982: Stewart C L; Stuhlmann H; Jähner D; Jaenisch R
De novo methylation, expression, and infectivity of retroviral genomes introduced into embryonal carcinoma cells.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(13):4098-102.
1982: Chumakov I; Stuhlmann H; Harbers K; Jaenisch R
Cloning of two genetically transmitted Moloney leukemia proviral genomes: correlation between biological activity of the cloned DNA and viral genome activation in the animal.
Journal of virology 1982;42(3):1088-98.
1982: Breindl M; Nath U; Jähner D; Jaenisch R
DNase I sensitivity of endogenous and exogenous proviral genome copies in M-MuLV-induced tumors of Mov-3 Mice.
Virology 1982;119(1):204-8.
1982: Harbers K; Schnieke A; Stuhlmann H; Jaenisch R
Infectivity and structure of molecular clones obtained from two genetically transmitted Moloney leukemia proviral genomes.
Nucleic acids research 1982;10(8):2521-37.
1982: Fiedler W; Nobis P; Jähner D; Jaenisch R
Differentiation and virus expression in BALB/Mo mice: endogenous Moloney leukemia virus is not activated in hematopoietic cells.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(6):1874-8.
1982: Jaenisch R; Harbers K; Jähner D; Stewart C; Stuhlmann H
DNA methylation, retroviruses, and embryogenesis.
Journal of cellular biochemistry 1982;20(4):331-6.
1981: Harbers K; Schnieke A; Stuhlmann H; Jähner D; Jaenisch R
DNA methylation and gene expression: endogenous retroviral genome becomes infectious after molecular cloning.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(12):7609-13.
1981: Harbers K; Jähner D; Jaenisch R
Microinjection of cloned retroviral genomes into mouse zygotes: integration and expression in the animal.
Nature 1981;293(5833):540-2.
1981: Stuhlmann H; Jähner D; Jaenisch R
Infectivity and methylation of retroviral genomes is correlated with expression in the animal.
Cell 1981;26(2 Pt 2):221-32.
1981: Jaenisch R; Jähner D; Nobis P; Simon I; Löhler J; Harbers K; Grotkopp D
Chromosomal position and activation of retroviral genomes inserted into the germ line of mice.
Cell 1981;24(2):519-29.
1980: Jähner D; Stuhlmann H; Jaenisch R
Conformation of free and of integrated Moloney leukemia virus proviral DNA in preleukemic and leukemic BALB/Mo mice.
Virology 1980;101(1):111-23.

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