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Farouc Jaffer

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Amit Saxena; Brian Thompson; Yoshiko Iwamoto; Chase W Kessinger; Charles P Lin; Jason R McCarthy; Farouc A Jaffer
High-resolution optical mapping of inflammatory macrophages following endovascular arterial injury.
Viviany R Taqueti; Farouc A Jaffer
High-resolution molecular imaging via intravital microscopy: illuminating vascular biology in vivo.
Arun K Thukkani; Farouc A Jaffer
Intravascular near-infrared fluorescence molecular imaging of atherosclerosis.

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All Publications

2013: Amit Saxena; Brian Thompson; Yoshiko Iwamoto; Chase W Kessinger; Charles P Lin; Jason R McCarthy; Farouc A Jaffer
High-resolution optical mapping of inflammatory macrophages following endovascular arterial injury.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 2013;15(3):282-9.
2013: Viviany R Taqueti; Farouc A Jaffer
High-resolution molecular imaging via intravital microscopy: illuminating vascular biology in vivo.
Integrative biology : quantitative biosciences from nano to macro 2013;5(2):278-90.
2013: Arun K Thukkani; Farouc A Jaffer
Intravascular near-infrared fluorescence molecular imaging of atherosclerosis.
American journal of nuclear medicine and molecular imaging 2013;3(3):217-31.
2012: Georgios Mallas; Adam Mauskapf; Dana H Brooks; Farouc A Jaffer; R Nika Nudelman; Amir Rosenthal; Vasilis Ntziachristos
Improving quantification of intravascular fluorescence imaging using structural information.
Physics in medicine and biology 2012;57(20):6395-406.
2012: James K Min; Seung-Jung Park; Michael J Pencina; Robert S Schwartz; Leslee J Shaw; Carlos van Mieghem; Patricia Apruzzese; Daniel S Berman; Matthew J Budoff; Jason H Cole; Allison M Dunning; Andrejs Erglis; Farouc A Jaffer; Bon-Kwon Koo; Jonathon Leipsic; Martin B Leon; Fay Y Lin; Jennifer Malpeso; G B John Mancini; Laura Mauri
Diagnostic accuracy of fractional flow reserve from anatomic CT angiography.
JAMA : the journal of the American Medical Association 2012;308(12):1237-45.
2012: Jason R McCarthy; Purvish Patel; Guy L Reed; Irina Y Sazonova; Brian D Thompson; Ralph Weissleder; Ion Botnaru; S Sibel Erdem; Tetsuya Hara; Charles P Lin; Farouc A Jaffer
Multifunctional nanoagent for thrombus-targeted fibrinolytic therapy.
Nanomedicine (London, England) 2012;7(7):1017-28.
2012: Tetsuya Hara; Brijesh Bhayana; Chase W Kessinger; Ashok Khatri; Charles P Lin; Jason R McCarthy; Guillermo J Tearney; Brian Thompson; Ralph Weissleder; Farouc A Jaffer
Molecular imaging of fibrin deposition in deep vein thrombosis using fibrin-targeted near-infrared fluorescence.
JACC. Cardiovascular imaging 2012;5(6):607-15.
2012: Hyeyoung Moon; Jagat Narula; Hyo Eun Park; Ki-Bae Seung; Sang-Hyun Ihm; Farouc A Jaffer; Jongeun Kang; Hyunseung Lee; Yong Taik Lim; Kiyuk Chang; Chaejoon Cheong; Kwan Soo Hong
Noninvasive assessment of myocardial inflammation by cardiovascular magnetic resonance in a rat model of experimental autoimmune myocarditis.
Circulation 2012;125(21):2603-12.
2012: Farouc A Jaffer
Shining light and illuminating murine atherosclerosis via optical coherence tomography.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(5):1068-9.
2012: Eric A Osborn; Farouc A Jaffer
The year in molecular imaging.
JACC. Cardiovascular imaging 2012;5(3):317-28.
2012: Jin-Oh Hahn; Farouc A Jaffer; Andrew T Reisner; H Harry Asada
Subject-specific estimation of central aortic blood pressure using an individualized transfer function: a preliminary feasibility study.
IEEE transactions on information technology in biomedicine : a publication of the IEEE Engineering in Medicine and Biology Society 2012;16(2):212-20.
2012: S Sibel Erdem; Tetsuya Hara; Farouc A Jaffer; Irina Y Sazonova; Jason R McCarthy
Detection and treatment of intravascular thrombi with magnetofluorescent nanoparticles.
Methods in enzymology 2012;508():191-209.
2011: Hongki Yoo; Brett E Bouma; Farouc A Jaffer; Jin Won Kim; Jason R McCarthy; Theodore Morse; Eman Namati; Vasilis Ntziachristos; Milen Shishkov; Roman Shubochkin; Guillermo J Tearney
Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo.
Nature medicine 2011;17(12):1680-4.
2011: Jason R McCarthy; Farouc A Jaffer
The role of nanomedicine in the imaging and therapy of thrombosis.
Nanomedicine (London, England) 2011;6(8):1291-3.
2011: James K Min; Robert S Schwartz; Daniel S Berman; Matthew J Budoff; Farouc A Jaffer; Jonathon Leipsic; Martin B Leon; G B John Mancini; Laura Mauri; Leslee J Shaw
Rationale and design of the DeFACTO (Determination of Fractional Flow Reserve by Anatomic Computed Tomographic AngiOgraphy) study.
Journal of cardiovascular computed tomography 2011;5(5):301-9.
2011: Melissa Suter; Atsushi Tanaka; Brett E Bouma; Farouc A Jaffer; Seemantini K Nadkarni; Giora Weisz; Guillermo J Tearney
Intravascular optical imaging technology for investigating the coronary artery.
JACC. Cardiovascular imaging 2011;4(9):1022-39.
2011: Farouc A Jaffer; Peter Libby; Georgios Mallas; Adam Mauskapf; R Nika Razansky; Amir Rosenthal; Ralph Weissleder; Marcella A Calfon; Vasilis Ntziachristos
Two-dimensional intravascular near-infrared fluorescence molecular imaging of inflammation in atherosclerosis and stent-induced vascular injury.
Journal of the American College of Cardiology 2011;57(25):2516-26.
2011: Claudio Vinegoni; Ion Botnaru; Elena Aikawa; Marcella A Calfon; Yoshiko Iwamoto; Eduardo J Folco; Vasilis Ntziachristos; Ralph Weissleder; Peter Libby; Farouc A Jaffer
Indocyanine green enables near-infrared fluorescence imaging of lipid-rich, inflamed atherosclerotic plaques.
Science translational medicine 2011;3(84):84ra45.
2011: Zeinab Hajjarian; Jingqun Xi; Farouc A Jaffer; Guillermo J Tearney; Seemantini K Nadkarni
Intravascular laser speckle imaging catheter for the mechanical evaluation of the arterial wall.
Journal of biomedical optics 2011;16(2):026005.
2011: Joseph A Ladapo; Farouc A Jaffer; Milton C Weinstein; Erika Sivarajan Froelicher
Projected cost-effectiveness of smoking cessation interventions in patients hospitalized with myocardial infarction.
Archives of internal medicine 2011;171(1):39-45.
2011: Georgios Mallas; Adam Mauskapf; Dana H Brooks; Marcella A Calfon; Farouc A Jaffer; R Nika Razansky; Amir Rosenthal; Vasilis Ntziachristos
Progress on multimodal molecular / anatomical intravascular imaging of coronary vessels combining near infrared fluorescence and ultrasound.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2011;2011():1117-20.
2011: Marcella A Calfon; Georgios Mallas; Adam Mauskapf; Vasilis Ntziachristos; R Nika Nudelman; Amir Rosenthal; Farouc A Jaffer
In vivo near infrared fluorescence (NIRF) intravascular molecular imaging of inflammatory plaque, a multimodal approach to imaging of atherosclerosis.
Journal of visualized experiments : JoVE 2011;(54):.
2011: Farouc A Jaffer
Intravital fluorescence microscopic molecular imaging of atherosclerosis.
Methods in molecular biology (Clifton, N.J.) 2011;680():131-40.
2010: Rahul Sakhuja; William M Suh; Farouc A Jaffer; Ik-Kyung Jang
Residual thrombogenic substrate after rupture of a lipid-rich plaque: possible mechanism of acute stent thrombosis?
Circulation 2010;122(22):2349-50.
2010: Eric A Osborn; Farouc A Jaffer
The year in molecular imaging.
JACC. Cardiovascular imaging 2010;3(11):1181-95.
2010: Kiyuk Chang; Sanjeev A Francis; Elena Aikawa; Jose-Luiz Figueiredo; Rainer H Kohler; Jason R McCarthy; Ralph Weissleder; Jorge Plutzky; Farouc A Jaffer
Pioglitazone suppresses inflammation in vivo in murine carotid atherosclerosis: novel detection by dual-target fluorescence molecular imaging.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(10):1933-9.
2010: Jason R McCarthy; Ethan Korngold; Ralph Weissleder; Farouc A Jaffer
A light-activated theranostic nanoagent for targeted macrophage ablation in inflammatory atherosclerosis.
Small (Weinheim an der Bergstrasse, Germany) 2010;6(18):2041-9.
2010: Marc S Sabatine; Farouc A Jaffer; Paul Staats; James R Stone
Case records of the Massachusetts General Hospital. Case 28-2010. A 32-year-old woman, 3 weeks post partum, with substernal chest pain.
The New England journal of medicine 2010;363(12):1164-73.
2010: R Nika Razansky; Amir Rosenthal; George Mallas; Daniel Razansky; Farouc A Jaffer; Vasilis Ntziachristos
Near-infrared fluorescence catheter system for two-dimensional intravascular imaging in vivo.
Optics express 2010;18(11):11372-81.
2010: Marcella A Calfon; Claudio Vinegoni; Vasilis Ntziachristos; Farouc A Jaffer
Intravascular near-infrared fluorescence molecular imaging of atherosclerosis: toward coronary arterial visualization of biologically high-risk plaques.
Journal of biomedical optics 2010;15(1):011107.
2010: Sharath Subramanian; Farouc A Jaffer; Ahmed Tawakol
Optical molecular imaging in atherosclerosis.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2010;17(1):135-44.
2009: Joseph A Ladapo; Farouc A Jaffer; Udo Hoffmann; Carey C Thomson; Fabian Bamberg; William Dec; David M Cutler; Milton C Weinstein; G Scott Gazelle
Clinical outcomes and cost-effectiveness of coronary computed tomography angiography in the evaluation of patients with chest pain.
Journal of the American College of Cardiology 2009;54(25):2409-22.
2009: Farouc A Jaffer
Assessing niacin as an atherosclerosis therapeutic agent valuable insights provided by high-resolution vascular magnetic resonance imaging.
Journal of the American College of Cardiology 2009;54(19):1795-6.
2009: Farouc A Jaffer; Peter Libby; Ralph Weissleder
Optical and multimodality molecular imaging: insights into atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(7):1017-24.
2009: Jason R McCarthy; Purvish Patel; Ion Botnaru; Pouneh Haghayeghi; Ralph Weissleder; Farouc A Jaffer
Multimodal nanoagents for the detection of intravascular thrombi.
Bioconjugate chemistry 2009;20(6):1251-5.
2009: Elena Aikawa; Masanori Aikawa; Peter Libby; Jose-Luiz Figueiredo; Gabriel Rusanescu; Yoshiko Iwamoto; Daiju Fukuda; Rainer H Kohler; Guo-Ping Shi; Farouc A Jaffer; Ralph Weissleder
Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease.
Circulation 2009;119(13):1785-94.
2009: Eric A Osborn; Farouc A Jaffer
The year in molecular imaging.
JACC. Cardiovascular imaging 2009;2(1):97-113.
2008: Eric A Osborn; Farouc A Jaffer
Advances in molecular imaging of atherosclerotic vascular disease.
Current opinion in cardiology 2008;23(6):620-8.
2008: Farouc A Jaffer; Claudio Vinegoni; Michael C John; Elena Aikawa; Herman K Gold; Aloke V Finn; Vasilis Ntziachristos; Peter Libby; Ralph Weissleder
Real-time catheter molecular sensing of inflammation in proteolytically active atherosclerosis.
Circulation 2008;118(18):1802-9.
2008: Matthias Nahrendorf; Elena Aikawa; Jose-Luiz Figueiredo; Lars Stangenberg; Susanne W van den Borne; W Matthijs Blankesteijn; David E Sosnovik; Farouc A Jaffer; Ching-Hsuan Tung; Ralph Weissleder
Transglutaminase activity in acute infarcts predicts healing outcome and left ventricular remodelling: implications for FXIII therapy and antithrombin use in myocardial infarction.
European heart journal 2008;29(4):445-54.
2008: Jin-Oh Hahn; H Harry Asada; Andrew T Reisner; Farouc A Jaffer
A new approach to reconstruction of central aortic blood pressure using 'adaptive' transfer function.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2008;2008():813-6.
2007: Elena Aikawa; Matthias Nahrendorf; Jose-Luiz Figueiredo; Filip K Swirski; Timur Shtatland; Rainer H Kohler; Farouc A Jaffer; Masanori Aikawa; Ralph Weissleder
Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo.
Circulation 2007;116(24):2841-50.
2007: Farouc A Jaffer; Peter Libby; Ralph Weissleder
Molecular imaging of cardiovascular disease.
Circulation 2007;116(9):1052-61.
2007: Farouc A Jaffer; Dong-Eog Kim; Luisa Quinti; Ching-Hsuan Tung; Elena Aikawa; Ashvin N Pande; Rainer H Kohler; Guo-Ping Shi; Peter Libby; Ralph Weissleder
Optical visualization of cathepsin K activity in atherosclerosis with a novel, protease-activatable fluorescence sensor.
Circulation 2007;115(17):2292-8.
2007: Sekar Kathiresan; Martin G Larson; Michelle J Keyes; Joseph F Polak; Philip A Wolf; Ralph B D'Agostino; Farouc A Jaffer; Melvin E Clouse; Daniel Levy; Warren J Manning; Christopher J O'Donnell
Assessment by cardiovascular magnetic resonance, electron beam computed tomography, and carotid ultrasonography of the distribution of subclinical atherosclerosis across Framingham risk strata.
The American journal of cardiology 2007;99(3):310-4.
2007: Elena Aikawa; Matthias Nahrendorf; David E Sosnovik; Vincent M Lok; Farouc A Jaffer; Masanori Aikawa; Ralph Weissleder
Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease.
Circulation 2007;115(3):377-86.
2006: Farouc A Jaffer; David E Sosnovik; Matthias Nahrendorf; Ralph Weissleder
Molecular imaging of myocardial infarction.
Journal of molecular and cellular cardiology 2006;41(6):921-33.
2006: Paula A Johnson; Farouc A Jaffer; Tomas G Neilan; Jo-Anne O Shepard; James R Stone
Case records of the Massachusetts General Hospital. Case 34-2006. A 72-year-old woman with nausea followed by hypotension and respiratory failure.
The New England journal of medicine 2006;355(19):2022-31.
2006: Matthias Nahrendorf; Farouc A Jaffer; Kimberly A Kelly; David E Sosnovik; Elena Aikawa; Peter Libby; Ralph Weissleder
Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis.
Circulation 2006;114(14):1504-11.
2006: Jason R McCarthy; Farouc A Jaffer; Ralph Weissleder
A macrophage-targeted theranostic nanoparticle for biomedical applications.
Small (Weinheim an der Bergstrasse, Germany) 2006;2(8-9):983-7.
2006: Filip K Swirski; Mikaël J Pittet; Moritz Kircher; Elena Aikawa; Farouc A Jaffer; Peter Libby; Ralph Weissleder
Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(27):10340-5.
2006: Farouc A Jaffer; Peter Libby; Ralph Weissleder
Molecular and cellular imaging of atherosclerosis: emerging applications.
Journal of the American College of Cardiology 2006;47(7):1328-38.
2006: Farouc A Jaffer; Matthias Nahrendorf; David E Sosnovik; Kimberly A Kelly; Elena Aikawa; Ralph Weissleder
Cellular imaging of inflammation in atherosclerosis using magnetofluorescent nanomaterials.
Molecular imaging 2006;5(2):85-92.
2006: Matthias Nahrendorf; Kai Hu; Stefan Frantz; Farouc A Jaffer; Ching-Hsuan Tung; Karl-Heinz Hiller; Sabine Voll; Peter Nordbeck; David E Sosnovik; Stefan Gattenlöhner; Mikhail Novikov; Gerhard Dickneite; Guy L Reed; Peter M Jakob; Anthony Rosenzweig; Wolfgang R Bauer; Ralph Weissleder; Georg Ertl
Factor XIII deficiency causes cardiac rupture, impairs wound healing, and aggravates cardiac remodeling in mice with myocardial infarction.
Circulation 2006;113(9):1196-202.
2006: Ashvin N Pande; Rainer H Kohler; Elena Aikawa; Ralph Weissleder; Farouc A Jaffer
Detection of macrophage activity in atherosclerosis in vivo using multichannel, high-resolution laser scanning fluorescence microscopy.
Journal of biomedical optics 2006;11(2):021009.
2005: Rodolfo Carrillo-Jimenez; Stuart L Houser; Farouc A Jaffer
Images in cardiovascular medicine. Culprit lesion atherothrombectomy during acute myocardial infarction: extraction of an acute coronary plaque rupture.
Circulation 2005;112(16):e267.
2005: Farouc A Jaffer; Ralph Weissleder
Molecular imaging in the clinical arena.
JAMA : the journal of the American Medical Association 2005;293(7):855-62.
2005: Dong-Eog Kim; Dawid Schellingerhout; Farouc A Jaffer; Ralph Weissleder; Ching-Hsuan Tung
Near-infrared fluorescent imaging of cerebral thrombi and blood-brain barrier disruption in a mouse model of cerebral venous sinus thrombosis.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2005;25(2):226-33.
2005: Ching-Hsuan Tung; Luisa Quinti; Farouc A Jaffer; Ralph Weissleder
A branched fluorescent peptide probe for imaging of activated platelets.
Molecular pharmaceutics 2005;2(1):92-5.
2004: Farouc A Jaffer; Ching-Hsuan Tung; Joanna J Wykrzykowska; Nan-Hui Ho; Aiilyan K Houng; Guy L Reed; Ralph Weissleder
Molecular imaging of factor XIIIa activity in thrombosis using a novel, near-infrared fluorescent contrast agent that covalently links to thrombi.
Circulation 2004;110(2):170-6.
2004: Farouc A Jaffer; Ralph Weissleder
Seeing within: molecular imaging of the cardiovascular system.
Circulation research 2004;94(4):433-45.
2003: Ching-Hsuan Tung; Nan-Hui Ho; Qing Zeng; Yi Tang; Farouc A Jaffer; Guy L Reed; Ralph Weissleder
Novel factor XIII probes for blood coagulation imaging.
Chembiochem : a European journal of chemical biology 2003;4(9):897-9.
2002: Farouc A Jaffer; Ching-Hsuan Tung; Robert E Gerszten; Ralph Weissleder
In vivo imaging of thrombin activity in experimental thrombi with thrombin-sensitive near-infrared molecular probe.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(11):1929-35.
2002: Farouc A Jaffer; Christopher J O'Donnell; Martin G Larson; Stephen K Chan; Kraig V Kissinger; Michelle J Kupka; Carol J Salton; René M Botnar; Daniel Levy; Warren J Manning
Age and sex distribution of subclinical aortic atherosclerosis: a magnetic resonance imaging examination of the Framingham Heart Study.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(5):849-54.
2002: Ching-Hsuan Tung; Robert E Gerszten; Farouc A Jaffer; Ralph Weissleder
A novel near-infrared fluorescence sensor for detection of thrombin activation in blood.
Chembiochem : a European journal of chemical biology 2002;3(2-3):207-11.
2001: S K Chan; Farouc A Jaffer; René M Botnar; Kraig V Kissinger; Lois Goepfert; Michael L Chuang; Christopher J O'Donnell; D Levy; Warren J Manning
Scan reproducibility of magnetic resonance imaging assessment of aortic atherosclerosis burden.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 2001;3(4):331-8.