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Mahendra Jain

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Bao-Zhu Yu; Shi Bai; Otto G Berg; Mahendra K Jain
Allosteric effect of amphiphile binding to phospholipase A(2).
Otto G Berg; Bao-Zhu Yu; Mahendra K Jain
Thermodynamic reciprocity of the inhibitor binding to the active site and the interface binding region of IB phospholipase A2.
Bao-Zhu Yu; Rajani Kaimal; Shi Bai; Khalid A El Sayed; Suren A Tatulian; Rafael Apitz-Castro; Mahendra K Jain; Ruitang Deng; Otto G Berg
Effect of guggulsterone and cembranoids of Commiphora mukul on pancreatic phospholipase A(2): role in hypocholesterolemia.

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All Publications

2009: Bao-Zhu Yu; Shi Bai; Otto G Berg; Mahendra K Jain
Allosteric effect of amphiphile binding to phospholipase A(2).
Biochemistry 2009;48(14):3219-29.
2009: Otto G Berg; Bao-Zhu Yu; Mahendra K Jain
Thermodynamic reciprocity of the inhibitor binding to the active site and the interface binding region of IB phospholipase A2.
Biochemistry 2009;48(14):3209-18.
2009: Bao-Zhu Yu; Rajani Kaimal; Shi Bai; Khalid A El Sayed; Suren A Tatulian; Rafael Apitz-Castro; Mahendra K Jain; Ruitang Deng; Otto G Berg
Effect of guggulsterone and cembranoids of Commiphora mukul on pancreatic phospholipase A(2): role in hypocholesterolemia.
Journal of natural products 2009;72(1):24-8.
2008: Shi Bai; Mahendra K Jain; Otto G Berg
Contiguous binding of decylsulfate on the interface-binding surface of pancreatic phospholipase A2.
Biochemistry 2008;47(9):2899-907.
2007: Bao-Zhu Yu; Rafael Apitz-Castro; Mahendra K Jain; Otto G Berg
Role of 57-72 loop in the allosteric action of bile salts on pancreatic IB phospholipase A(2): regulation of fat and cholesterol homeostasis.
Biochimica et biophysica acta 2007;1768(10):2478-90.
2006: Mahendra K Jain; Otto G Berg
Coupling of the i-face and the active site of phospholipase A2 for interfacial activation.
Current opinion in chemical biology 2006;10(5):473-9.
2006: Yu-Cheng Tsai; Bao-Zhu Yu; Yu-Zhen Wang; Junghuei Chen; Mahendra K Jain
Desolvation map of the i-face of phospholipase A2.
Biochimica et biophysica acta 2006;1758(5):653-65.
2005: Bao-Zhu Yu; Tatyana Polenova; Mahendra K Jain; Otto G Berg
Premicellar complexes of sphingomyelinase mediate enzyme exchange for the stationary phase turnover.
Biochimica et biophysica acta 2005;1712(2):137-51.
2005: Bao-Zhu Yu; Ying H Pan; Marcel J W Janssen; Brian J Bahnson; Mahendra K Jain
Kinetic and structural properties of disulfide engineered phospholipase A2: insight into the role of disulfide bonding patterns.
Biochemistry 2005;44(9):3369-79.
2004: Yolanda Cajal; Otto G Berg; Mahendra K Jain
Origins of delays in monolayer kinetics: phospholipase A2 paradigm.
Biochemistry 2004;43(28):9256-64.
2004: Otto G Berg; Bao-Zhu Yu; Cherry Chang; Karl A Koehler; Mahendra K Jain
Cooperative binding of monodisperse anionic amphiphiles to the i-face: phospholipase A2-paradigm for interfacial binding.
Biochemistry 2004;43(25):7999-8013.
2004: Otto G Berg; Bao-Zhu Yu; Rafael Apitz-Castro; Mahendra K Jain
Phosphatidylinositol-specific phospholipase C forms different complexes with monodisperse and micellar phosphatidylcholine.
Biochemistry 2004;43(7):2080-90.
2003: Bao-Zhu Yu; Rafael Apitz-Castro; Ming-Daw Tsai; Mahendra K Jain
Interaction of monodisperse anionic amphiphiles with the i-face of secreted phospholipase A2.
Biochemistry 2003;42(20):6293-301.
2002: Ying H Pan; Bao-Zhu Yu; Otto G Berg; Mahendra K Jain; Brian J Bahnson
Crystal structure of phospholipase A2 complex with the hydrolysis products of platelet activating factor: equilibrium binding of fatty acid and lysophospholipid-ether at the active site may be mutually exclusive.
Biochemistry 2002;41(50):14790-800.
2002: Ying H Pan; Bao-Zhu Yu; Alan G Singer; Farideh Ghomashchi; Gérard Lambeau; Michael H Gelb; Mahendra K Jain; Brian J Bahnson
Crystal structure of human group X secreted phospholipase A2. Electrostatically neutral interfacial surface targets zwitterionic membranes.
The Journal of biological chemistry 2002;277(32):29086-93.
2002: Bao-Zhu Yu; David Zakim; Mahendra K Jain
Processive interfacial catalytic turnover by Bacillus cereus sphingomyelinase on sphingomyelin vesicles.
Biochimica et biophysica acta 2002;1583(1):122-32.
2001: T M Epstein; Bao-Zhu Yu; Ying H Pan; S P Tutton; Badri P Maliwal; Mahendra K Jain; Brian J Bahnson
The basis for k(cat) impairment in prophospholipase A(2) from the anion-assisted dimer structure.
Biochemistry 2001;40(38):11411-22.
2001: Ying H Pan; T M Epstein; Mahendra K Jain; Brian J Bahnson
Five coplanar anion binding sites on one face of phospholipase A2: relationship to interface binding.
Biochemistry 2001;40(3):609-17.
2000: Michael H Gelb; Jin-Hye Min; Mahendra K Jain
Do membrane-bound enzymes access their substrates from the membrane or aqueous phase: interfacial versus non-interfacial enzymes.
Biochimica et biophysica acta 2000;1488(1-2):20-7.
2000: Bao-Zhu Yu; Ming-Jye Poi; Udupi A Ramagopal; R Jain; Suryanarayanarao Ramakumar; Otto G Berg; Ming-Daw Tsai; K Sekar; Mahendra K Jain
Structural basis of the anionic interface preference and kcat* activation of pancreatic phospholipase A2.
Biochemistry 2000;39(40):12312-23.
2000: J W Chen; Chandra Dodia; Sheldon I Feinstein; Mahendra K Jain; Aron B Fisher
1-Cys peroxiredoxin, a bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities.
The Journal of biological chemistry 2000;275(37):28421-7.
2000: Bao-Zhu Yu; Marcel J W Janssen; HM Verheij; Mahendra K Jain
Control of the chemical step by leucine-31 of pancreatic phospholipase A2.
Biochemistry 2000;39(19):5702-11.
2000: A Liechty; Junghuei Chen; Mahendra K Jain
Origin of antibacterial stasis by polymyxin B in Escherichia coli.
Biochimica et biophysica acta 2000;1463(1):55-64.
2000: JT Oh; Yolanda Cajal; E M Skowronska; Shimshon Belkin; Junghuei Chen; Tina K Van Dyk; M Sasser; Mahendra K Jain
Cationic peptide antimicrobials induce selective transcription of micF and osmY in Escherichia coli.
Biochimica et biophysica acta 2000;1463(1):43-54.
1999: Bao-Zhu Yu; Otto G Berg; Mahendra K Jain
Hydrolysis of monodisperse phosphatidylcholines by phospholipase A2 occurs on vessel walls and air bubbles.
Biochemistry 1999;38(32):10449-56.
1999: Bao-Zhu Yu; J Rogers; Ming-Daw Tsai; C Pidgeon; Mahendra K Jain
Contributions of residues of pancreatic phospholipase A2 to interfacial binding, catalysis, and activation.
Biochemistry 1999;38(15):4875-84.
1998: JT Oh; Yolanda Cajal; Prasad S Dhurjati; Tina K Van Dyk; Mahendra K Jain
Cecropins induce the hyperosmotic stress response in Escherichia coli.
Biochimica et biophysica acta 1998;1415(1):235-45.
1998: Bao-Zhu Yu; J Rogers; G R Nicol; Klaus H Theopold; K Seshadri; S Vishweshwara; Mahendra K Jain
Catalytic significance of the specificity of divalent cations as KS* and kcat* cofactors for secreted phospholipase A2.
Biochemistry 1998;37(36):12576-87.
1998: Yolanda Cajal; Chandra Dodia; Aron B Fisher; Mahendra K Jain
Calcium-triggered selective intermembrane exchange of phospholipids by the lung surfactant protein SP-A.
Biochemistry 1998;37(35):12178-88.
1998: Y Lin; Farideh Ghomashchi; Robert Nielsen; Y Snitko; Bao-Zhu Yu; S K Han; Wonhwa Cho; David C Wilton; Mahendra K Jain; Bruce H Robinson; Michael H Gelb
Binding of bee venom and human group IIa phospholipases A2 to membranes: a minor role for electrostatics.
Biochemical Society transactions 1998;26(3):341-5.
1998: J Rogers; Bao-Zhu Yu; Ming-Daw Tsai; Otto G Berg; Mahendra K Jain
Cationic residues 53 and 56 control the anion-induced interfacial k*cat activation of pancreatic phospholipase A2.
Biochemistry 1998;37(26):9549-56.
1998: JT Oh; Tina K Van Dyk; Yolanda Cajal; Prasad S Dhurjati; M Sasser; Mahendra K Jain
Osmotic stress in viable Escherichia coli as the basis for the antibiotic response by polymyxin B.
Biochemical and biophysical research communications 1998;246(3):619-23.
1998: Farideh Ghomashchi; Y Lin; Mark Hixon; Bao-Zhu Yu; R Annand; Mahendra K Jain; Michael H Gelb
Interfacial recognition by bee venom phospholipase A2: insights into nonelectrostatic molecular determinants by charge reversal mutagenesis.
Biochemistry 1998;37(19):6697-710.
1998: Otto G Berg; Yolanda Cajal; G L Butterfoss; R L Grey; M Asunción Alsina; Bao-Zhu Yu; Mahendra K Jain
Interfacial activation of triglyceride lipase from Thermomyces (Humicola) lanuginosa: kinetic parameters and a basis for control of the lid.
Biochemistry 1998;37(19):6615-27.
1997: Otto G Berg; J Rogers; Bao-Zhu Yu; J Yao; L S Romsted; Mahendra K Jain
Thermodynamic and kinetic basis of interfacial activation: resolution of binding and allosteric effects on pancreatic phospholipase A2 at zwitterionic interfaces.
Biochemistry 1997;36(47):14512-30.
1997: K Sekar; Subramaniam Eswaramoorthy; Mahendra K Jain; Muttaiya Sundaralingam
Crystal structure of the complex of bovine pancreatic phospholipase A2 with the inhibitor 1-hexadecyl-3-(trifluoroethyl)-sn-glycero-2-phosphomethanol,.
Biochemistry 1997;36(46):14186-91.
1997: Bao-Zhu Yu; J Rogers; G Ranadive; S Baker; David C Wilton; Rafael Apitz-Castro; Mahendra K Jain
Gossypol modification of Ala-1 of secreted phospholipase A2: a probe for the kinetic effects of sulfate glycoconjugates.
Biochemistry 1997;36(41):12400-11.
1997: Yolanda Cajal; Mahendra K Jain
Synergism between mellitin and phospholipase A2 from bee venom: apparent activation by intervesicle exchange of phospholipids.
Biochemistry 1997;36(13):3882-93.
1997: Bao-Zhu Yu; Farideh Ghomashchi; Yolanda Cajal; R R Annand; Otto G Berg; Michael H Gelb; Mahendra K Jain
Use of an imperfect neutral diluent and outer vesicle layer scooting mode hydrolysis to analyze the interfacial kinetics, inhibition, and substrate preferences of bee venom phospholipase A2.
Biochemistry 1997;36(13):3870-81.
1997: K Sekar; Bao-Zhu Yu; J Rogers; J Lutton; Xiaoping Liu; X Chen; Ming-Daw Tsai; Mahendra K Jain; Muttaiya Sundaralingam
Phospholipase A2 engineering. Structural and functional roles of the highly conserved active site residue aspartate-99.
Biochemistry 1997;36(11):3104-14.
1997: Yolanda Cajal; J M Boggs; Mahendra K Jain
Salt-triggered intermembrane exchange of phospholipids and hemifusion by myelin basic protein.
Biochemistry 1997;36(9):2566-76.
1997: T S Kim; C S Sundaresh; Sheldon I Feinstein; Chandra Dodia; William R Skach; Mahendra K Jain; T Nagase; N Seki; K Ishikawa; N Nomura; Aron B Fisher
Identification of a human cDNA clone for lysosomal type Ca2+-independent phospholipase A2 and properties of the expressed protein.
The Journal of biological chemistry 1997;272(4):2542-50.
1996: Baohua Huang; B Z Yu; J Rogers; In-Ja L Byeon; K Sekar; X Chen; Muttaiya Sundaralingam; Ming-Daw Tsai; Mahendra K Jain
Phospholipase A2 engineering. Deletion of the C-terminus segment changes substrate specificity and uncouples calcium and substrate binding at the zwitterionic interface.
Biochemistry 1996;35(37):12164-74.
1996: J Rogers; Bao-Zhu Yu; S V Serves; G M Tsivgoulis; D N Sotiropoulos; P V Ioannou; Mahendra K Jain
Kinetic basis for the substrate specificity during hydrolysis of phospholipids by secreted phospholipase A2.
Biochemistry 1996;35(29):9375-84.
1996: Yolanda Cajal; J Ghanta; K Easwaran; A Surolia; Mahendra K Jain
Specificity for the exchange of phospholipids through polymyxin B mediated intermembrane molecular contacts.
Biochemistry 1996;35(18):5684-95.
1996: Yolanda Cajal; J Rogers; Otto G Berg; Mahendra K Jain
Intermembrane molecular contacts by polymyxin B mediate exchange of phospholipids.
Biochemistry 1996;35(1):299-308.
1995: T Bayburt; Bao-Zhu Yu; I Street; Farideh Ghomashchi; F Laliberté; Hélène Perrier; Z Wang; R Homan; Mahendra K Jain; Michael H Gelb
Continuous, vesicle-based fluorimetric assays of 14- and 85-kDa phospholipases A2.
Analytical biochemistry 1995;232(1):7-23.
1995: X Liu; H Zhu; Baohua Huang; J Rogers; B Z Yu; A Kumar; Mahendra K Jain; Muttaiya Sundaralingam; Ming-Daw Tsai
Phospholipase A2 engineering. Probing the structural and functional roles of N-terminal residues with site-directed mutagenesis, X-ray, and NMR.
Biochemistry 1995;34(22):7322-34.
1995: Mahendra K Jain; Bao-Zhu Yu; J M Rogers; A E Smith; E T Boger; R L Ostrander; A L Rheingold
Specific competitive inhibitor of secreted phospholipase A2 from berries of Schinus terebinthifolius.
Phytochemistry 1995;39(3):537-47.
1995: Yolanda Cajal; Otto G Berg; Mahendra K Jain
Direct vesicle-vesicle exchange of phospholipids mediated by polymyxin B.
Biochemical and biophysical research communications 1995;210(3):746-52.
1994: Y Li; B Z Yu; H Zhu; Mahendra K Jain; Ming-Daw Tsai
Phospholipase A2 engineering. Structural and functional roles of the highly conserved active site residue aspartate-49.
Biochemistry 1994;33(49):14714-22.
1994: F Bartoli; H K Lin; Farideh Ghomashchi; Michael H Gelb; Mahendra K Jain; Rafael Apitz-Castro
Tight binding inhibitors of 85-kDa phospholipase A2 but not 14-kDa phospholipase A2 inhibit release of free arachidonate in thrombin-stimulated human platelets.
The Journal of biological chemistry 1994;269(22):15625-30.
1994: Mahendra K Jain; C D Krause; J T Buckley; T Bayburt; Michael H Gelb
Characterization of interfacial catalysis by Aeromonas hydrophila lipase/acyltransferase in the highly processive scooting mode.
Biochemistry 1994;33(17):5011-20.
1993: Mahendra K Jain; Badri P Maliwal
Spectroscopic properties of the states of pig pancreatic phospholipase A2 at interfaces and their possible molecular origin.
Biochemistry 1993;32(44):11838-46.
1993: Mahendra K Jain; Bao-Zhu Yu; Otto G Berg
Relationship of interfacial equilibria to interfacial activation of phospholipase A2.
Biochemistry 1993;32(42):11319-29.
1993: Mahendra K Jain; J Rogers; HS Hendrickson; Otto G Berg
The chemical step is not rate-limiting during the hydrolysis by phospholipase A2 of mixed micelles of phospholipid and detergent.
Biochemistry 1993;32(32):8360-7.
1993: Bao-Zhu Yu; Otto G Berg; Mahendra K Jain
The divalent cation is obligatory for the binding of ligands to the catalytic site of secreted phospholipase A2.
Biochemistry 1993;32(25):6485-92.
1993: T Bayburt; Bao-Zhu Yu; H K Lin; J Browning; Mahendra K Jain; Michael H Gelb
Human nonpancreatic secreted phospholipase A2: interfacial parameters, substrate specificities, and competitive inhibitors.
Biochemistry 1993;32(2):573-82.
1992: C M Dupureur; B Z Yu; J A Mamone; Mahendra K Jain; Ming-Daw Tsai
Phospholipase A2 engineering. The structural and functional roles of aromaticity and hydrophobicity in the conserved phenylalanine-22 and phenylalanine-106 aromatic sandwich.
Biochemistry 1992;31(43):10576-83.
1992: Mahendra K Jain; Farideh Ghomashchi; Bao-Zhu Yu; T Bayburt; D Murphy; D Houck; J Brownell; J C Reid; J E Solowiej; S M Wong
Fatty acid amides: scooting mode-based discovery of tight-binding competitive inhibitors of secreted phospholipases A2.
Journal of medicinal chemistry 1992;35(19):3584-6.
1992: Mahendra K Jain; Bao-Zhu Yu; J Rogers; Michael H Gelb; Ming-Daw Tsai; EK Hendrickson; HS Hendrickson
Interfacial catalysis by phospholipase A2: the rate-limiting step for enzymatic turnover.
Biochemistry 1992;31(34):7841-7.
1992: C M Dupureur; B Z Yu; Mahendra K Jain; J P Noel; T Deng; Y Li; In-Ja L Byeon; Ming-Daw Tsai
Phospholipase A2 engineering. Structural and functional roles of highly conserved active site residues tyrosine-52 and tyrosine-73.
Biochemistry 1992;31(28):6402-13.
1992: J Rogers; Bao-Zhu Yu; Mahendra K Jain
Basis for the anomalous effect of competitive inhibitors on the kinetics of hydrolysis of short-chain phosphatidylcholines by phospholipase A2.
Biochemistry 1992;31(26):6056-62.
1992: Farideh Ghomashchi; S Schüttel; Mahendra K Jain; Michael H Gelb
Kinetic analysis of a high molecular weight phospholipase A2 from rat kidney: divalent metal-dependent trapping of enzyme on product-containing vesicles.
Biochemistry 1992;31(15):3814-24.
1991: Mahendra K Jain; W J Tao; J Rogers; C Arenson; H Eibl; Bao-Zhu Yu
Active-site-directed specific competitive inhibitors of phospholipase A2: novel transition-state analogues.
Biochemistry 1991;30(42):10256-68.
1991: Farideh Ghomashchi; Bao-Zhu Yu; E D Mihelich; Mahendra K Jain; Michael H Gelb
Kinetic characterization of phospholipase A2 modified by manoalogue.
Biochemistry 1991;30(40):9559-69.
1991: Rafael Apitz-Castro; Mahendra K Jain; F Bartoli; Eliades Ledezma; M C Ruiz; R Salas
Evidence for direct coupling of primary agonist-receptor interaction to the exposure of functional IIb-IIIa complexes in human blood platelets. Results from studies with the antiplatelet compound ajoene.
Biochimica et biophysica acta 1991;1094(3):269-80.
1991: Mahendra K Jain; J Rogers; Otto G Berg; Michael H Gelb
Interfacial catalysis by phospholipase A2: activation by substrate replenishment.
Biochemistry 1991;30(29):7340-8.
1991: Mahendra K Jain; G Ranadive; Bao-Zhu Yu; H M Verheij
Interfacial catalysis by phospholipase A2: monomeric enzyme is fully catalytically active at the bilayer interface.
Biochemistry 1991;30(29):7330-40.
1991: Farideh Ghomashchi; Bao-Zhu Yu; Otto G Berg; Mahendra K Jain; Michael H Gelb
Interfacial catalysis by phospholipase A2: substrate specificity in vesicles.
Biochemistry 1991;30(29):7318-29.
1991: Mahendra K Jain; Bao-Zhu Yu; J Rogers; G N Ranadive; Otto G Berg
Interfacial catalysis by phospholipase A2: dissociation constants for calcium, substrate, products, and competitive inhibitors.
Biochemistry 1991;30(29):7306-17.
1991: Otto G Berg; Bao-Zhu Yu; J Rogers; Mahendra K Jain
Interfacial catalysis by phospholipase A2: determination of the interfacial kinetic rate constants.
Biochemistry 1991;30(29):7283-97.
1989: Mahendra K Jain; W Yuan; Michael H Gelb
Competitive inhibition of phospholipase A2 in vesicles.
Biochemistry 1989;28(10):4135-9.
1989: Mahendra K Jain; J Rogers
Substrate specificity for interfacial catalysis by phospholipase A2 in the scooting mode.
Biochimica et biophysica acta 1989;1003(1):91-7.
1989: Mahendra K Jain; O G Berg
The kinetics of interfacial catalysis by phospholipase A2 and regulation of interfacial activation: hopping versus scooting.
Biochimica et biophysica acta 1989;1002(2):127-56.
1989: Mahendra K Jain; Bao-Zhu Yu; Arkadiusz Kozubek
Binding of phospholipase A2 to zwitterionic bilayers is promoted by lateral segregation of anionic amphiphiles.
Biochimica et biophysica acta 1989;980(1):23-32.
1989: Bao-Zhu Yu; Mahendra K Jain
Segregation of anionic lipophiles in bilayers monitored by binding of cationic dye NK-529.
Biochimica et biophysica acta 1989;980(1):15-22.
1988: Rafael Apitz-Castro; Eliades Ledezma; J Escalante; Alicia Jorquera; F M Pinãte; J Moreno-Rea; G Carrillo; O Leal; Mahendra K Jain
Reversible prevention of platelet activation by (E,Z)-4,5,9-trithiadodeca-1,6,11-triene 9-oxide (ajoene) in dogs under extracorporeal circulation.
Arzneimittel-Forschung 1988;38(7):901-4.
1988: Mahendra K Jain; J Rogers; G H DeHaas
Kinetics of binding of phospholipase A2 to lipid/water interfaces and its relationship to interfacial activation.
Biochimica et biophysica acta 1988;940(1):51-62.
1987: Mahendra K Jain; W L Vaz
Dehydration of the lipid-protein microinterface on binding of phospholipase A2 to lipid bilayers.
Biochimica et biophysica acta 1987;905(1):1-8.
1986: Rafael Apitz-Castro; Eliades Ledezma; J Escalante; Mahendra K Jain
The molecular basis of the antiplatelet action of ajoene: direct interaction with the fibrinogen receptor.
Biochemical and biophysical research communications 1986;141(1):145-50.