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Mahendra Jain
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44
Yu, Bao-Zhu
26
Berg, Otto
15
Gelb, Michael
14
Rogers, J
12
Cajal, Yolanda
11
Tsai, Ming-Daw
10
Ghomashchi, Farideh
8
Apitz-Castro, Rafael
5
Bahnson, Brian
5
Pan, Ying
4
Sundaralingam, Muttaiya
3
Van Dyk, Tina
3
Sekar, K
3
Oh, JT
3
Ledezma, Eliades
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All Publications
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2009: Yu Bao-Zhu; Bai Shi; Berg Otto G; Jain Mahendra K
Allosteric effect of amphiphile binding to phospholipase A(2).
Biochemistry 2009;48(14):3219-29.
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2009: Berg Otto G; Yu Bao-Zhu; Jain Mahendra K
Thermodynamic reciprocity of the inhibitor binding to the active site and the interface binding region of IB phospholipase A2.
Biochemistry 2009;48(14):3209-18.
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2009: Yu Bao-Zhu; Kaimal Rajani; Bai Shi; El Sayed Khalid A; Tatulian Suren A; Apitz Rafael J; Jain Mahendra K; Deng Ruitang; Berg Otto G
Effect of guggulsterone and cembranoids of Commiphora mukul on pancreatic phospholipase A(2): role in hypocholesterolemia.
Journal of natural products 2009;72(1):24-8.
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2008: Bai Shi; Jain Mahendra K; Berg Otto G
Contiguous binding of decylsulfate on the interface-binding surface of pancreatic phospholipase A2.
Biochemistry 2008;47(9):2899-907.
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2007: Yu Bao-Zhu; Apitz-Castro Rafael J; Jain Mahendra K; Berg Otto G
Role of 57-72 loop in the allosteric action of bile salts on pancreatic IB phospholipase A(2): regulation of fat and cholesterol homeostasis.
Biochimica et biophysica acta 2007;1768(10):2478-90.
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2006: Jain Mahendra Kumar; Berg Otto G
Coupling of the i-face and the active site of phospholipase A2 for interfacial activation.
Current opinion in chemical biology 2006;10(5):473-9.
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2006: Tsai Yu-Cheng; Yu Bao-Zhu; Wang Yu-Zhen; Chen Junghuei; Jain Mahendra K
Desolvation map of the i-face of phospholipase A2.
Biochimica et biophysica acta 2006;1758(5):653-65.
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2005: Yu Bao-Zhu; Polenova Tatyana; Jain Mahendra Kumar; Berg Otto G
Premicellar complexes of sphingomyelinase mediate enzyme exchange for the stationary phase turnover.
Biochimica et biophysica acta 2005;1712(2):137-51.
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2005: Yu Bao-Zhu; Pan Ying H; Janssen Marcel J W; Bahnson Brian J; Jain Mahendra K
Kinetic and structural properties of disulfide engineered phospholipase A2: insight into the role of disulfide bonding patterns.
Biochemistry 2005;44(9):3369-79.
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2004: Cajal Yolanda; Berg Otto G; Jain Mahendra Kumar
Origins of delays in monolayer kinetics: phospholipase A2 paradigm.
Biochemistry 2004;43(28):9256-64.
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2004: Berg Otto G; Yu Bao-Zhu; Chang Cherry; Koehler Karl A; Jain Mahendra K
Cooperative binding of monodisperse anionic amphiphiles to the i-face: phospholipase A2-paradigm for interfacial binding.
Biochemistry 2004;43(25):7999-8013.
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2004: Berg Otto G; Yu Bao-Zhu; Apitz-Castro Rafael J; Jain Mahendra K
Phosphatidylinositol-specific phospholipase C forms different complexes with monodisperse and micellar phosphatidylcholine.
Biochemistry 2004;43(7):2080-90.
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2003: Yu Bao-Zhu; Apitz-Castro Rafael; Tsai Ming-Daw; Jain Mahendra K
Interaction of monodisperse anionic amphiphiles with the i-face of secreted phospholipase A2.
Biochemistry 2003;42(20):6293-301.
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2002: Pan Ying H; Yu Bao-Zhu; Berg Otto G; Jain Mahendra K; Bahnson Brian J
Crystal structure of phospholipase A2 complex with the hydrolysis products of platelet activating factor: equilibrium binding of fatty acid and lysophospholipid-ether at the active site may be mutually exclusive.
Biochemistry 2002;41(50):14790-800.
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2002: Pan Ying H; Yu Bao-Zhu; Singer Alan G; Ghomashchi Farideh; Lambeau Gerard; Gelb Michael H; Jain Mahendra K; Bahnson Brian J
Crystal structure of human group X secreted phospholipase A2. Electrostatically neutral interfacial surface targets zwitterionic membranes.
The Journal of biological chemistry 2002;277(32):29086-93.
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2002: Yu Bao-Zhu; Zakim David; Jain Mahendra K
Processive interfacial catalytic turnover by Bacillus cereus sphingomyelinase on sphingomyelin vesicles.
Biochimica et biophysica acta 2002;1583(1):122-32.
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2001: Epstein T M; Yu B Z; Pan Y H; Tutton S P; Maliwal B P; Jain M K; Bahnson B J
The basis for k(cat) impairment in prophospholipase A(2) from the anion-assisted dimer structure.
Biochemistry 2001;40(38):11411-22.
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2001: Pan Y H; Epstein T M; Jain M K; Bahnson B J
Five coplanar anion binding sites on one face of phospholipase A2: relationship to interface binding.
Biochemistry 2001;40(3):609-17.
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2000: Gelb M H; Min J H; Jain M K
Do membrane-bound enzymes access their substrates from the membrane or aqueous phase: interfacial versus non-interfacial enzymes.
Biochimica et biophysica acta 2000;1488(1-2):20-7.
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2000: Yu B Z; Poi M J; Ramagopal U A; Jain R; Ramakumar S; Berg O G; Tsai M D; Sekar K; Jain M K
Structural basis of the anionic interface preference and kcat* activation of pancreatic phospholipase A2.
Biochemistry 2000;39(40):12312-23.
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2000: Chen J W; Dodia C; Feinstein S I; Jain M K; Fisher A B
1-Cys peroxiredoxin, a bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities.
The Journal of biological chemistry 2000;275(37):28421-7.
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2000: Yu B Z; Janssen M J; Verheij H M; Jain M K
Control of the chemical step by leucine-31 of pancreatic phospholipase A2.
Biochemistry 2000;39(19):5702-11.
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2000: Liechty A; Chen J; Jain M K
Origin of antibacterial stasis by polymyxin B in Escherichia coli.
Biochimica et biophysica acta 2000;1463(1):55-64.
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2000: Oh J T; Cajal Y; Skowronska E M; Belkin S; Chen J; Van Dyk T K; Sasser M; Jain M K
Cationic peptide antimicrobials induce selective transcription of micF and osmY in Escherichia coli.
Biochimica et biophysica acta 2000;1463(1):43-54.
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1999: Yu B Z; Berg O G; Jain M K
Hydrolysis of monodisperse phosphatidylcholines by phospholipase A2 occurs on vessel walls and air bubbles.
Biochemistry 1999;38(32):10449-56.
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1999: Yu B Z; Rogers J; Tsai M D; Pidgeon C; Jain M K
Contributions of residues of pancreatic phospholipase A2 to interfacial binding, catalysis, and activation.
Biochemistry 1999;38(15):4875-84.
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1998: Oh J T; Cajal Y; Dhurjati P S; Van Dyk T K; Jain M K
Cecropins induce the hyperosmotic stress response in Escherichia coli.
Biochimica et biophysica acta 1998;1415(1):235-45.
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1998: Yu B Z; Rogers J; Nicol G R; Theopold K H; Seshadri K; Vishweshwara S; Jain M K
Catalytic significance of the specificity of divalent cations as KS* and kcat* cofactors for secreted phospholipase A2.
Biochemistry 1998;37(36):12576-87.
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1998: Cajal Y; Dodia C; Fisher A B; Jain M K
Calcium-triggered selective intermembrane exchange of phospholipids by the lung surfactant protein SP-A.
Biochemistry 1998;37(35):12178-88.
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1998: Lin Y; Ghomashchi F; Nielsen R; Snitko Y; Yu B Z; Han S K; Cho W; Wilton D C; Jain M K; Robinson B H; Gelb M H
Binding of bee venom and human group IIa phospholipases A2 to membranes: a minor role for electrostatics.
Biochemical Society transactions 1998;26(3):341-5.
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1998: Rogers J; Yu B Z; Tsai M D; Berg O G; Jain M K
Cationic residues 53 and 56 control the anion-induced interfacial k*cat activation of pancreatic phospholipase A2.
Biochemistry 1998;37(26):9549-56.
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1998: Oh J T; Van Dyk T K; Cajal Y; Dhurjati P S; Sasser M; Jain M K
Osmotic stress in viable Escherichia coli as the basis for the antibiotic response by polymyxin B.
Biochemical and biophysical research communications 1998;246(3):619-23.
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1998: Ghomashchi F; Lin Y; Hixon M S; Yu B Z; Annand R; Jain M K; Gelb M H
Interfacial recognition by bee venom phospholipase A2: insights into nonelectrostatic molecular determinants by charge reversal mutagenesis.
Biochemistry 1998;37(19):6697-710.
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1998: Berg O G; Cajal Y; Butterfoss G L; Grey R L; Alsina M A; Yu B Z; Jain M K
Interfacial activation of triglyceride lipase from Thermomyces (Humicola) lanuginosa: kinetic parameters and a basis for control of the lid.
Biochemistry 1998;37(19):6615-27.
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1997: Berg O G; Rogers J; Yu B Z; Yao J; Romsted L S; Jain M K
Thermodynamic and kinetic basis of interfacial activation: resolution of binding and allosteric effects on pancreatic phospholipase A2 at zwitterionic interfaces.
Biochemistry 1997;36(47):14512-30.
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1997: Sekar K; Eswaramoorthy S; Jain M K; Sundaralingam M
Crystal structure of the complex of bovine pancreatic phospholipase A2 with the inhibitor 1-hexadecyl-3-(trifluoroethyl)-sn-glycero-2-phosphomethanol,.
Biochemistry 1997;36(46):14186-91.
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1997: Yu B Z; Rogers J; Ranadive G; Baker S; Wilton D C; Apitz-Castro R; Jain M K
Gossypol modification of Ala-1 of secreted phospholipase A2: a probe for the kinetic effects of sulfate glycoconjugates.
Biochemistry 1997;36(41):12400-11.
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1997: Cajal Y; Jain M K
Synergism between mellitin and phospholipase A2 from bee venom: apparent activation by intervesicle exchange of phospholipids.
Biochemistry 1997;36(13):3882-93.
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1997: Yu B Z; Ghomashchi F; Cajal Y; Annand R R; Berg O G; Gelb M H; Jain M K
Use of an imperfect neutral diluent and outer vesicle layer scooting mode hydrolysis to analyze the interfacial kinetics, inhibition, and substrate preferences of bee venom phospholipase A2.
Biochemistry 1997;36(13):3870-81.
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1997: Sekar K; Yu B Z; Rogers J; Lutton J; Liu X; Chen X; Tsai M D; Jain M K; Sundaralingam M
Phospholipase A2 engineering. Structural and functional roles of the highly conserved active site residue aspartate-99.
Biochemistry 1997;36(11):3104-14.
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1997: Cajal Y; Boggs J M; Jain M K
Salt-triggered intermembrane exchange of phospholipids and hemifusion by myelin basic protein.
Biochemistry 1997;36(9):2566-76.
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1997: Kim T S; Sundaresh C S; Feinstein S I; Dodia C; Skach W R; Jain M K; Nagase T; Seki N; Ishikawa K; Nomura N; Fisher A B
Identification of a human cDNA clone for lysosomal type Ca2+-independent phospholipase A2 and properties of the expressed protein.
The Journal of biological chemistry 1997;272(4):2542-50.
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1996: Huang B; Yu B Z; Rogers J; Byeon I J; Sekar K; Chen X; Sundaralingam M; Tsai M D; Jain M K
Phospholipase A2 engineering. Deletion of the C-terminus segment changes substrate specificity and uncouples calcium and substrate binding at the zwitterionic interface.
Biochemistry 1996;35(37):12164-74.
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1996: Rogers J; Yu B Z; Serves S V; Tsivgoulis G M; Sotiropoulos D N; Ioannou P V; Jain M K
Kinetic basis for the substrate specificity during hydrolysis of phospholipids by secreted phospholipase A2.
Biochemistry 1996;35(29):9375-84.
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1996: Cajal Y; Ghanta J; Easwaran K; Surolia A; Jain M K
Specificity for the exchange of phospholipids through polymyxin B mediated intermembrane molecular contacts.
Biochemistry 1996;35(18):5684-95.
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1996: Cajal Y; Rogers J; Berg O G; Jain M K
Intermembrane molecular contacts by polymyxin B mediate exchange of phospholipids.
Biochemistry 1996;35(1):299-308.
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1995: Bayburt T; Yu B Z; Street I; Ghomashchi F; Laliberté F; Perrier H; Wang Z; Homan R; Jain M K; Gelb M H
Continuous, vesicle-based fluorimetric assays of 14- and 85-kDa phospholipases A2.
Analytical biochemistry 1995;232(1):7-23.
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1995: Liu X; Zhu H; Huang B; Rogers J; Yu B Z; Kumar A; Jain M K; Sundaralingam M; Tsai M D
Phospholipase A2 engineering. Probing the structural and functional roles of N-terminal residues with site-directed mutagenesis, X-ray, and NMR.
Biochemistry 1995;34(22):7322-34.
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1995: Jain M K; Yu B Z; Rogers J M; Smith A E; Boger E T; Ostrander R L; Rheingold A L
Specific competitive inhibitor of secreted phospholipase A2 from berries of Schinus terebinthifolius.
Phytochemistry 1995;39(3):537-47.
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1995: Cajal Y; Berg O G; Jain M K
Direct vesicle-vesicle exchange of phospholipids mediated by polymyxin B.
Biochemical and biophysical research communications 1995;210(3):746-52.
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1994: Li Y; Yu B Z; Zhu H; Jain M K; Tsai M D
Phospholipase A2 engineering. Structural and functional roles of the highly conserved active site residue aspartate-49.
Biochemistry 1994;33(49):14714-22.
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1994: Bartoli F; Lin H K; Ghomashchi F; Gelb M H; Jain M K; Apitz-Castro R
Tight binding inhibitors of 85-kDa phospholipase A2 but not 14-kDa phospholipase A2 inhibit release of free arachidonate in thrombin-stimulated human platelets.
The Journal of biological chemistry 1994;269(22):15625-30.
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1994: Jain M K; Krause C D; Buckley J T; Bayburt T; Gelb M H
Characterization of interfacial catalysis by Aeromonas hydrophila lipase/acyltransferase in the highly processive scooting mode.
Biochemistry 1994;33(17):5011-20.
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1993: Jain M K; Maliwal B P
Spectroscopic properties of the states of pig pancreatic phospholipase A2 at interfaces and their possible molecular origin.
Biochemistry 1993;32(44):11838-46.
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1993: Jain M K; Yu B Z; Berg O G
Relationship of interfacial equilibria to interfacial activation of phospholipase A2.
Biochemistry 1993;32(42):11319-29.
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1993: Jain M K; Rogers J; Hendrickson H S; Berg O G
The chemical step is not rate-limiting during the hydrolysis by phospholipase A2 of mixed micelles of phospholipid and detergent.
Biochemistry 1993;32(32):8360-7.
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1993: Yu B Z; Berg O G; Jain M K
The divalent cation is obligatory for the binding of ligands to the catalytic site of secreted phospholipase A2.
Biochemistry 1993;32(25):6485-92.
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1993: Bayburt T; Yu B Z; Lin H K; Browning J; Jain M K; Gelb M H
Human nonpancreatic secreted phospholipase A2: interfacial parameters, substrate specificities, and competitive inhibitors.
Biochemistry 1993;32(2):573-82.
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1992: Dupureur C M; Yu B Z; Mamone J A; Jain M K; Tsai M D
Phospholipase A2 engineering. The structural and functional roles of aromaticity and hydrophobicity in the conserved phenylalanine-22 and phenylalanine-106 aromatic sandwich.
Biochemistry 1992;31(43):10576-83.
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1992: Jain M K; Yu B Z; Rogers J; Gelb M H; Tsai M D; Hendrickson E K; Hendrickson H S
Interfacial catalysis by phospholipase A2: the rate-limiting step for enzymatic turnover.
Biochemistry 1992;31(34):7841-7.
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1992: Jain M K; Ghomashchi F; Yu B Z; Bayburt T; Murphy D; Houck D; Brownell J; Reid J C; Solowiej J E; Wong S M
Fatty acid amides: scooting mode-based discovery of tight-binding competitive inhibitors of secreted phospholipases A2.
Journal of medicinal chemistry 1992;35(19):3584-6.
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1992: Dupureur C M; Yu B Z; Jain M K; Noel J P; Deng T; Li Y; Byeon I J; Tsai M D
Phospholipase A2 engineering. Structural and functional roles of highly conserved active site residues tyrosine-52 and tyrosine-73.
Biochemistry 1992;31(28):6402-13.
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1992: Rogers J; Yu B Z; Jain M K
Basis for the anomalous effect of competitive inhibitors on the kinetics of hydrolysis of short-chain phosphatidylcholines by phospholipase A2.
Biochemistry 1992;31(26):6056-62.
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1992: Ghomashchi F; Schüttel S; Jain M K; Gelb M H
Kinetic analysis of a high molecular weight phospholipase A2 from rat kidney: divalent metal-dependent trapping of enzyme on product-containing vesicles.
Biochemistry 1992;31(15):3814-24.
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1991: Jain M K; Tao W J; Rogers J; Arenson C; Eibl H; Yu B Z
Active-site-directed specific competitive inhibitors of phospholipase A2: novel transition-state analogues.
Biochemistry 1991;30(42):10256-68.
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1991: Ghomashchi F; Yu B Z; Mihelich E D; Jain M K; Gelb M H
Kinetic characterization of phospholipase A2 modified by manoalogue.
Biochemistry 1991;30(40):9559-69.
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1991: Apitz-Castro R; Jain M K; Bartoli F; Ledezma E; Ruiz M C; Salas R
Evidence for direct coupling of primary agonist-receptor interaction to the exposure of functional IIb-IIIa complexes in human blood platelets. Results from studies with the antiplatelet compound ajoene.
Biochimica et biophysica acta 1991;1094(3):269-80.
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1991: Jain M K; Rogers J; Berg O; Gelb M H
Interfacial catalysis by phospholipase A2: activation by substrate replenishment.
Biochemistry 1991;30(29):7340-8.
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1991: Jain M K; Ranadive G; Yu B Z; Verheij H M
Interfacial catalysis by phospholipase A2: monomeric enzyme is fully catalytically active at the bilayer interface.
Biochemistry 1991;30(29):7330-40.
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1991: Ghomashchi F; Yu B Z; Berg O; Jain M K; Gelb M H
Interfacial catalysis by phospholipase A2: substrate specificity in vesicles.
Biochemistry 1991;30(29):7318-29.
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1991: Jain M K; Yu B Z; Rogers J; Ranadive G N; Berg O G
Interfacial catalysis by phospholipase A2: dissociation constants for calcium, substrate, products, and competitive inhibitors.
Biochemistry 1991;30(29):7306-17.
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1991: Berg O G; Yu B Z; Rogers J; Jain M K
Interfacial catalysis by phospholipase A2: determination of the interfacial kinetic rate constants.
Biochemistry 1991;30(29):7283-97.
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1989: Jain M K; Yuan W; Gelb M H
Competitive inhibition of phospholipase A2 in vesicles.
Biochemistry 1989;28(10):4135-9.
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1989: Jain M K; Rogers J
Substrate specificity for interfacial catalysis by phospholipase A2 in the scooting mode.
Biochimica et biophysica acta 1989;1003(1):91-7.
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1989: Jain M K; Berg O G
The kinetics of interfacial catalysis by phospholipase A2 and regulation of interfacial activation: hopping versus scooting.
Biochimica et biophysica acta 1989;1002(2):127-56.
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1989: Jain M K; Yu B Z; Kozubek A
Binding of phospholipase A2 to zwitterionic bilayers is promoted by lateral segregation of anionic amphiphiles.
Biochimica et biophysica acta 1989;980(1):23-32.
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1989: Yu B Z; Jain M K
Segregation of anionic lipophiles in bilayers monitored by binding of cationic dye NK-529.
Biochimica et biophysica acta 1989;980(1):15-22.
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1988: Apitz-Castro R; Ledezma E; Escalante J; Jorquera A; Pinãte F M; Moreno-Rea J; Carrillo G; Leal O; Jain M K
Reversible prevention of platelet activation by (E,Z)-4,5,9-trithiadodeca-1,6,11-triene 9-oxide (ajoene) in dogs under extracorporeal circulation.
Arzneimittel-Forschung 1988;38(7):901-4.
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1988: Jain M K; Rogers J; DeHaas G H
Kinetics of binding of phospholipase A2 to lipid/water interfaces and its relationship to interfacial activation.
Biochimica et biophysica acta 1988;940(1):51-62.
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1987: Jain M K; Vaz W L
Dehydration of the lipid-protein microinterface on binding of phospholipase A2 to lipid bilayers.
Biochimica et biophysica acta 1987;905(1):1-8.
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1986: Apitz-Castro R; Ledezma E; Escalante J; Jain M K
The molecular basis of the antiplatelet action of ajoene: direct interaction with the fibrinogen receptor.
Biochemical and biophysical research communications 1986;141(1):145-50.
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