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Rakesh Jain

Research Profile

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Publications

TOP 3
Ou Chen; Jian Cui; Dai Fukumura; Hee-Sun Han; Daniel K Harris; Rakesh K Jain; He Wei; Cliff Wong; Jing Zhao; Vikash P Chauhan; Moungi G Bawendi
Compact high-quality CdSe-CdS core-shell nanocrystals with narrow emission linewidths and suppressed blinking.
Hee-Sun Han; Daniel K Harris; Rakesh K Jain; Jungmin Lee; John D Martin; Dai Fukumura; Moungi Bawendi
Spatial charge configuration regulates nanoparticle transport and binding behavior in vivo.
David P Kodack; Alisha Lussiez; Sidra Mahmood; Matija Snuderl; Youngchul Song; Bakhos A Tannous; Hiroshi Yamashita; Walid S Kamoun; Eleanor Ager; Euiheon Chung; Annique M M J Duyverman; April F Eichler; Jeffrey A Engelman; Christian T Farrar; Dai Fukumura; Shom Goel; Lotte Hiddingh; Yuhui Huang; Joao Incio; Rakesh K Jain
Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases.

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All Publications

2013: Ou Chen; Jian Cui; Dai Fukumura; Hee-Sun Han; Daniel K Harris; Rakesh K Jain; He Wei; Cliff Wong; Jing Zhao; Vikash P Chauhan; Moungi G Bawendi
Compact high-quality CdSe-CdS core-shell nanocrystals with narrow emission linewidths and suppressed blinking.
Nature materials 2013;12(5):445-51.
2013: Hee-Sun Han; Daniel K Harris; Rakesh K Jain; Jungmin Lee; John D Martin; Dai Fukumura; Moungi Bawendi
Spatial charge configuration regulates nanoparticle transport and binding behavior in vivo.
Angewandte Chemie (International ed. in English) 2013;52(5):1414-9.
2012: David P Kodack; Alisha Lussiez; Sidra Mahmood; Matija Snuderl; Youngchul Song; Bakhos A Tannous; Hiroshi Yamashita; Walid S Kamoun; Eleanor Ager; Euiheon Chung; Annique M M J Duyverman; April F Eichler; Jeffrey A Engelman; Christian T Farrar; Dai Fukumura; Shom Goel; Lotte Hiddingh; Yuhui Huang; Joao Incio; Rakesh K Jain
Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(45):E3119-27.
2012: Yuhui Huang; Rakesh K Jain; Walid S Kamoun; Pierre Leblanc; John D Martin; Margaret R Martin; Lance L Munn; Jean Nezivar; Marek Ancukiewicz; Dan G Duda; Dai Fukumura; Peigen Huang; Elda Righi; Michael Santosuosso; Fabrizio Vianello; Jianping Yuan; Mark C Poznansky
Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(43):17561-6.
2012: Jieqiong Liu; Kamila Naxerova; Marek Ancukiewicz; Yves Boucher; Wei Chen; Benjamin Diop-Frimpong; Shom Goel; Rakesh K Jain; Shan Liao; Lei Xu
TGF-β blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(41):16618-23.
2012: Triantafyllos Stylianopoulos; Nabeel Bardeesy; Yves Boucher; Vikash P Chauhan; Benjamin Diop-Frimpong; Cristina R Ferrone; Francis J Hornicek; Saloni R Jain; John D Martin; Lance L Munn; Barbara L Smith; Rakesh K Jain
Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(38):15101-8.
2012: Sergey V Kozin; Lance L Munn; Dan G Duda; Rakesh K Jain
Neovascularization after irradiation: what is the source of newly formed vessels in recurring tumors?
Journal of the National Cancer Institute 2012;104(12):899-905.
2012: Vikash P Chauhan; Ou Chen; Dai Fukumura; Walid S Kamoun; John D Martin; Zoran Popović; Triantafyllos Stylianopoulos; Moungi G Bawendi; Rakesh K Jain
Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner.
Nature nanotechnology 2012;7(6):383-8.
2012: Shom Goel; Dai Fukumura; Rakesh K Jain
Normalization of the tumor vasculature through oncogenic inhibition: an emerging paradigm in tumor biology.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(20):E1214.
2012: Shom Goel; Andus Hon-Kit Wong; Rakesh K Jain
Vascular normalization as a therapeutic strategy for malignant and nonmalignant disease.
Cold Spring Harbor perspectives in medicine 2012;2(3):a006486.
2012: Janet M Tse; James A Tyrrell; Sarah A Wilcox-Adelman; Yves Boucher; Gang Cheng; Rakesh K Jain; Lance L Munn
Mechanical compression drives cancer cells toward invasive phenotype.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(3):911-6.
2012: A Gregory Sorensen; Meiyun Wang; Patrick Y Wen; Dominique Jennings; Heisoog Kim; Pavlina Polaskova; Marek Ancukiewicz; Tracy T Batchelor; Kyrre E Emblem; Percy Ivy; Rakesh K Jain
Increased survival of glioblastoma patients who respond to antiangiogenic therapy with elevated blood perfusion.
Cancer research 2012;72(2):402-7.
2011: Vikash P Chauhan; Ou Chen; Jian Cui; Dai Fukumura; Moungi G Bawendi; Zoran Popović; Rakesh K Jain
Fluorescent nanorods and nanospheres for real-time in vivo probing of nanoparticle shape-dependent tumor penetration.
Angewandte Chemie (International ed. in English) 2011;50(48):11417-20.
2011: Shan Liao; Lance L Munn; Nancy H Ruddle; Gang Cheng; David A Conner; Dai Fukumura; Yuhui Huang; Rakesh K Jain; Raju S Kucherlapati; Timothy P Padera
Impaired lymphatic contraction associated with immunosuppression.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(46):18784-9.
2011: Gang Cheng; Emmanuelle di Tomaso; Dai Fukumura; Rakesh K Jain; Hon Kit Wong; Delphine A Lacorre; Shan Liao; Patrick Au; Lance L Munn
Engineered blood vessel networks connect to host vasculature via wrapping-and-tapping anastomosis.
Blood 2011;118(17):4740-9.
2011: Igor Garkavtsev; Marcie A Glicksman; Arpita Mukhopadhyay; Randall T Peterson; Hon Kit Wong; Vikash P Chauhan; Rakesh K Jain
Dehydro-alpha-lapachone, a plant product with antivascular activity.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(28):11596-601.
2011: Sergey V Kozin; Lance L Munn; Dan G Duda; Rakesh K Jain
Is vasculogenesis crucial for the regrowth of irradiated tumours?
Nature reviews. Cancer 2011;11(7):532.
2011: Peigen Huang; Rakesh K Jain; Susan V Westmoreland; Dai Fukumura
Spontaneous nonthymic tumors in SCID mice.
Comparative medicine 2011;61(3):227-34.
2011: Heisoog Kim; Ciprian Catana; Eva-Maria Ratai; Ovidiu C Andronesi; Dominique L Jennings; Tracy T Batchelor; Rakesh K Jain; A Gregory Sorensen
Serial magnetic resonance spectroscopy reveals a direct metabolic effect of cediranib in glioblastoma.
Cancer research 2011;71(11):3745-52.
2011: April F Eichler; Euiheon Chung; David P Kodack; Jay S Loeffler; Dai Fukumura; Rakesh K Jain
The biology of brain metastases-translation to new therapies.
Nature reviews. Clinical oncology 2011;8(6):344-56.
2011: Sachie Hiratsuka; Shom Goel; Walid S Kamoun; Yoshiro Maru; Dai Fukumura; Dan G Duda; Rakesh K Jain
Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(9):3725-30.
2011: Benjamin Diop-Frimpong; Vikash P Chauhan; Stephen Krane; Yves Boucher; Rakesh K Jain
Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(7):2909-14.
2011: Cliff Wong; Triantafyllos Stylianopoulos; Jian Cui; John Martin; Vikash P Chauhan; Wen Jiang; Zoran Popovic; Rakesh K Jain; Moungi G Bawendi; Dai Fukumura
Multistage nanoparticle delivery system for deep penetration into tumor tissue.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(6):2426-31.
2011: James W Baish; Triantafyllos Stylianopoulos; Ryan M Lanning; Walid S Kamoun; Dai Fukumura; Lance L Munn; Rakesh K Jain
Scaling rules for diffusive drug delivery in tumor and normal tissues.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(5):1799-803.
2011: Yuhui Huang; Matija Snuderl; Rakesh K Jain
Polarization of tumor-associated macrophages: a novel strategy for vascular normalization and antitumor immunity.
Cancer cell 2011;19(1):1-2.
2011: Sachie Hiratsuka; Dan G Duda; Yuhui Huang; Shom Goel; Tatsuki Sugiyama; Takashi Nagasawa; Dai Fukumura; Rakesh K Jain
C-X-C receptor type 4 promotes metastasis by activating p38 mitogen-activated protein kinase in myeloid differentiation antigen (Gr-1)-positive cells.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(1):302-7.
2011: Vikash P Chauhan; Yves Boucher; Triantafyllos Stylianopoulos; Rakesh K Jain
Delivery of molecular and nanoscale medicine to tumors: transport barriers and strategies.
Annual review of chemical and biomolecular engineering 2011;2():281-98.
2011: Michelle R Dawson; Sung-Suk Chae; Rakesh K Jain; Dan G Duda
Direct evidence for lineage-dependent effects of bone marrow stromal cells on tumor progression.
American journal of cancer research 2011;1(2):144-54.
2011: Christian T Farrar; Walid S Kamoun; Carsten D Ley; Young R Kim; Ciprian Catana; Seon J Kwon; Bruce R Rosen; Rakesh K Jain; A Gregory Sorensen
Sensitivity of MRI tumor biomarkers to VEGFR inhibitor therapy in an orthotopic mouse glioma model.
PloS one 2011;6(3):e17228.
2011: Emmanuelle di Tomaso; Matija Snuderl; Walid S Kamoun; Dan G Duda; Pavan K Auluck; Ladan Fazlollahi; Ovidiu C Andronesi; Matthew P Frosch; Patrick Y Wen; Scott R Plotkin; E Tessa Hedley-Whyte; A Gregory Sorensen; Tracy T Batchelor; Rakesh K Jain
Glioblastoma recurrence after cediranib therapy in patients: lack of "rebound" revascularization as mode of escape.
Cancer research 2011;71(1):19-28.
2010: Dan G Duda; Annique M M J Duyverman; Mitsutomo Kohno; Matija Snuderl; Ernst J A Steller; Dai Fukumura; Rakesh K Jain
Malignant cells facilitate lung metastasis by bringing their own soil.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(50):21677-82.
2010: Triantafyllos Stylianopoulos; Benjamin Diop-Frimpong; Lance L Munn; Rakesh K Jain
Diffusion anisotropy in collagen gels and tumors: the effect of fiber network orientation.
Biophysical journal 2010;99(10):3119-28.
2010: Zoran Popović; Wenhao Liu; Vikash P Chauhan; Jungmin Lee; Cliff Wong; Andrew B Greytak; Numpon Insin; Daniel G Nocera; Dai Fukumura; Rakesh K Jain; Moungi G Bawendi
A nanoparticle size series for in vivo fluorescence imaging.
Angewandte Chemie (International ed. in English) 2010;49(46):8649-52.
2010: Rakesh K Jain; Triantafyllos Stylianopoulos
Delivering nanomedicine to solid tumors.
Nature reviews. Clinical oncology 2010;7(11):653-64.
2010: Triantafyllos Stylianopoulos; Ming-Zher Poh; Numpon Insin; Moungi G Bawendi; Dai Fukumura; Lance L Munn; Rakesh K Jain
Diffusion of particles in the extracellular matrix: the effect of repulsive electrostatic interactions.
Biophysical journal 2010;99(5):1342-9.
2010: Shan Liao; Timothy P Padera; Rakesh K Jain
Notch leads lymphatics and links them to blood vessels.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(9):1682-3.
2010: Walid S Kamoun; Sung-Suk Chae; Delphine A Lacorre; James A Tyrrell; Mariela Mitre; Marijn A Gillissen; Dai Fukumura; Rakesh K Jain; Lance L Munn
Simultaneous measurement of RBC velocity, flux, hematocrit and shear rate in vascular networks.
Nature methods 2010;7(8):655-60.
2010: Tracy T Batchelor; Dan G Duda; Emmanuelle di Tomaso; Marek Ancukiewicz; Scott R Plotkin; Elizabeth Gerstner; April F Eichler; Jan Drappatz; Fred H Hochberg; Thomas Benner; David N Louis; Kenneth S Cohen; Houng Chea; Alexis Exarhopoulos; Jay S Loeffler; Marsha A Moses; Percy Ivy; A Gregory Sorensen; Patrick Y Wen; Rakesh K Jain
Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(17):2817-23.
2010: Hon Kit Wong; Johanna Lahdenranta; Walid S Kamoun; Annie W Chan; Andrea I McClatchey; Scott R Plotkin; Rakesh K Jain; Emmanuelle di Tomaso
Anti-vascular endothelial growth factor therapies as a novel therapeutic approach to treating neurofibromatosis-related tumors.
Cancer research 2010;70(9):3483-93.
2010: Dai Fukumura; Dan G Duda; Lance L Munn; Rakesh K Jain
Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models.
Microcirculation (New York, N.Y. : 1994) 2010;17(3):206-25.
2010: Christian T Farrar; Walid S Kamoun; Carsten D Ley; Young R Kim; Seon J Kwon; Guangping Dai; Bruce R Rosen; Emmanuelle di Tomaso; Rakesh K Jain; A Gregory Sorensen
In vivo validation of MRI vessel caliber index measurement methods with intravital optical microscopy in a U87 mouse brain tumor model.
Neuro-oncology 2010;12(4):341-50.
2010: David G Kirsch; Philip M Santiago; Emmanuelle di Tomaso; Julie M Sullivan; Wu-Shiun Hou; Talya Dayton; Laura B Jeffords; Pooja Sodha; Kim L Mercer; Rhianna Cohen; Osamu Takeuchi; Stanley J Korsmeyer; Roderick T Bronson; Carla F. Kim; Kevin M Haigis; Rakesh K Jain; Tyler Jacks
p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis.
Science (New York, N.Y.) 2010;327(5965):593-6.
2010: Wenhao Liu; Andrew B Greytak; Jungmin Lee; Cliff R Wong; Jongnam Park; Lisa F Marshall; Wen Jiang; Peter N Curtin; Alice Y Ting; Daniel G Nocera; Dai Fukumura; Rakesh K Jain; Moungi G Bawendi
Compact biocompatible quantum dots via RAFT-mediated synthesis of imidazole-based random copolymer ligand.
Journal of the American Chemical Society 2010;132(2):472-83.
2010: Peter M Allen; Wenhao Liu; Vikash P Chauhan; Jungmin Lee; Alice Y Ting; Dai Fukumura; Rakesh K Jain; Moungi G Bawendi
InAs(ZnCdS) quantum dots optimized for biological imaging in the near-infrared.
Journal of the American Chemical Society 2010;132(2):470-1.
2010: Christopher G Willett; Dan G Duda; Marek Ancukiewicz; Mira Shah; Brian G Czito; Rex Bentley; Martin Poleski; Hiroshi Fujita; Gregory Y Lauwers; Madeline Carroll; Douglas Tyler; Christopher R Mantyh; Paul Shellito; Daniel C Chung; Jeffrey W Clark; Rakesh K Jain
A safety and survival analysis of neoadjuvant bevacizumab with standard chemoradiation in a phase I/II study compared with standard chemoradiation in locally advanced rectal cancer.
The oncologist 2010;15(8):845-51.
2010: Dan G Duda; Christopher G Willett; Marek Ancukiewicz; Emmanuelle di Tomaso; Mira Shah; Brian G Czito; Rex Bentley; Martin Poleski; Gregory Y Lauwers; Madeline Carroll; Douglas Tyler; Christopher Mantyh; Paul Shellito; Jeffrey W Clark; Rakesh K Jain
Plasma soluble VEGFR-1 is a potential dual biomarker of response and toxicity for bevacizumab with chemoradiation in locally advanced rectal cancer.
The oncologist 2010;15(6):577-83.
2009: Lei Xu; Dan G Duda; Emmanuelle di Tomaso; Marek Ancukiewicz; Daniel C Chung; Gregory Y Lauwers; Rekha Samuel; Paul Shellito; Brian G Czito; Pei-Chun Lin; Martin Poleski; Rex Bentley; Jeffrey W Clark; Christopher G Willett; Rakesh K Jain
Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer.
Cancer research 2009;69(20):7905-10.
2009: Scott R Plotkin; Anat Stemmer-Rachamimov; Fred G Barker; Chris Halpin; Timothy P Padera; Alex Tyrrell; A Gregory Sorensen; Rakesh K Jain; Emmanuelle di Tomaso
Hearing improvement after bevacizumab in patients with neurofibromatosis type 2.
The New England journal of medicine 2009;361(4):358-67.
2009: Vikash P Chauhan; Ryan M Lanning; Benjamin Diop-Frimpong; Wilson Mok; Edward B Brown; Timothy P Padera; Yves Boucher; Rakesh K Jain
Multiscale measurements distinguish cellular and interstitial hindrances to diffusion in vivo.
Biophysical journal 2009;97(1):330-6.
2009: A Gregory Sorensen; Tracy T Batchelor; Wei-Ting Zhang; Poe-Jou Chen; Priscilla Yeo; Meiyun Wang; Dominique Jennings; Patrick Y Wen; Johanna Lahdenranta; Marek Ancukiewicz; Emmanuelle di Tomaso; Dan G Duda; Rakesh K Jain
A "vascular normalization index" as potential mechanistic biomarker to predict survival after a single dose of cediranib in recurrent glioblastoma patients.
Cancer research 2009;69(13):5296-300.
2009: Andrew X Zhu; Dushyant V Sahani; Dan G Duda; Emmanuelle di Tomaso; Marek Ancukiewicz; Onofrio A Catalano; Vivek Sindhwani; Lawrence S Blaszkowsky; Sam S Yoon; Johanna Lahdenranta; Pankaj Bhargava; Jeffrey A Meyerhardt; Jeffrey W Clark; Eunice L Kwak; Aram F Hezel; Rebecca Miksad; Thomas A Abrams; Peter C Enzinger; Charlie S Fuchs; David P Ryan; Rakesh K Jain
Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a phase II study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(18):3027-35.
2009: Christopher G Willett; Dan G Duda; Emmanuelle di Tomaso; Yves Boucher; Marek Ancukiewicz; Dushyant V Sahani; Johanna Lahdenranta; Daniel C Chung; Alan J Fischman; Gregory Y Lauwers; Paul Shellito; Brian G Czito; Terence Z Wong; Erik Paulson; Martin Poleski; Zeljko Vujaskovic; Rex Bentley; Helen X Chen; Jeffrey W Clark; Rakesh K Jain
Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(18):3020-6.
2009: Rakesh K Jain
A new target for tumor therapy.
The New England journal of medicine 2009;360(25):2669-71.
2009: Andrew S Chi; A Gregory Sorensen; Rakesh K Jain; Tracy T Batchelor
Angiogenesis as a therapeutic target in malignant gliomas.
The oncologist 2009;14(6):621-36.
2009: Rakesh K Jain; Dan G Duda; Christopher G Willett; Dushyant V Sahani; Andrew X Zhu; Jay S Loeffler; Tracy T Batchelor; A Gregory Sorensen
Biomarkers of response and resistance to antiangiogenic therapy.
Nature reviews. Clinical oncology 2009;6(6):327-38.
2009: Walid S Kamoun; Carsten D Ley; Christian T Farrar; Annique M Duyverman; Johanna Lahdenranta; Delphine A Lacorre; Tracy T Batchelor; Emmanuelle di Tomaso; Dan G Duda; Lance L Munn; Dai Fukumura; A Gregory Sorensen; Rakesh K Jain
Edema control by cediranib, a vascular endothelial growth factor receptor-targeted kinase inhibitor, prolongs survival despite persistent brain tumor growth in mice.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(15):2542-52.
2009: Elizabeth R Gerstner; A Gregory Sorensen; Rakesh K Jain; Tracy T Batchelor
Anti-vascular endothelial growth factor therapy for malignant glioma.
Current neurology and neuroscience reports 2009;9(3):254-62.
2009: Mai X Luong; Joshua Tam; Qingcong Lin; Jeroen Hagendoorn; Kathryn J Moore; Timothy P Padera; Brian Seed; Dai Fukumura; Raju Kucherlapati; Rakesh K Jain
Lack of lymphatic vessel phenotype in LYVE-1/CD44 double knockout mice.
Journal of cellular physiology 2009;219(2):430-7.
2009: Elizabeth R Gerstner; Dan G Duda; Emmanuelle di Tomaso; Peter A Ryg; Jay S Loeffler; A Gregory Sorensen; Percy Ivy; Rakesh K Jain; Tracy T Batchelor
VEGF inhibitors in the treatment of cerebral edema in patients with brain cancer.
Nature reviews. Clinical oncology 2009;6(4):229-36.
2009: Johanna Lahdenranta; Jeroen Hagendoorn; Timothy P Padera; Tohru Hoshida; Gregory Nelson; Satoshi Kashiwagi; Rakesh K Jain; Dai Fukumura
Endothelial nitric oxide synthase mediates lymphangiogenesis and lymphatic metastasis.
Cancer research 2009;69(7):2801-8.
2009: Wilson Mok; Triantafyllos Stylianopoulos; Yves Boucher; Rakesh K Jain
Mathematical modeling of herpes simplex virus distribution in solid tumors: implications for cancer gene therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(7):2352-60.
2009: Jean Y Perentes; Dan G Duda; Rakesh K Jain
Visualizing anti-tumor immune responses in vivo.
Disease models & mechanisms 2009;2(3-4):107-10.
2009: Jean Y Perentes; Trevor McKee; Carsten D Ley; Hannah Mathiew; Michelle Dawson; Timothy P Padera; Lance L Munn; Rakesh K Jain; Yves Boucher
In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts.
Nature methods 2009;6(2):143-5.
2009: Joshua Tam; Dai Fukumura; Rakesh K Jain
A mathematical model of murine metabolic regulation by leptin: energy balance and defense of a stable body weight.
Cell metabolism 2009;9(1):52-63.
2009: Euiheon Chung; Hiroshi Yamashita; Patrick Au; Bakhos A Tannous; Dai Fukumura; Rakesh K Jain
Secreted Gaussia luciferase as a biomarker for monitoring tumor progression and treatment response of systemic metastases.
PloS one 2009;4(12):e8316.
2009: Michelle R Dawson; Dan G Duda; Sung-Suk Chae; Dai Fukumura; Rakesh K Jain
VEGFR1 activity modulates myeloid cell infiltration in growing lung metastases but is not required for spontaneous metastasis formation.
PloS one 2009;4(9):e6525.
2009: Emmanuelle di Tomaso; Nyall London; Daniel Fuja; James Logie; James A Tyrrell; Walid Kamoun; Lance L Munn; Rakesh K Jain
PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment.
PloS one 2009;4(4):e5123.
2009: Joshua Tam; Dan G Duda; Jean Y Perentes; Rehan S Quadri; Dai Fukumura; Rakesh K Jain
Blockade of VEGFR2 and not VEGFR1 can limit diet-induced fat tissue expansion: role of local versus bone marrow-derived endothelial cells.
PloS one 2009;4(3):e4974.
2009: Gang Cheng; Janet Tse; Rakesh K Jain; Lance L Munn
Micro-environmental mechanical stress controls tumor spheroid size and morphology by suppressing proliferation and inducing apoptosis in cancer cells.
PloS one 2009;4(2):e4632.
2008: A Gregory Sorensen; Tracy T Batchelor; Patrick Y Wen; Wei-Ting Zhang; Rakesh K Jain
Response criteria for glioma.
Nature clinical practice. Oncology 2008;5(11):634-44.
2008: Timothy P Padera; Rakesh K Jain
VEGFR3: a new target for antiangiogenesis therapy?
Developmental cell 2008;15(2):178-9.
2008: Timothy P Padera; Angera H Kuo; Tohru Hoshida; Shan Liao; Jennifer Lobo; Kevin R Kozak; Dai Fukumura; Rakesh K Jain
Differential response of primary tumor versus lymphatic metastasis to VEGFR-2 and VEGFR-3 kinase inhibitors cediranib and vandetanib.
Molecular cancer therapeutics 2008;7(8):2272-9.
2008: Peigen Huang; Dan G Duda; Rakesh K Jain; Dai Fukumura
Histopathologic findings and establishment of novel tumor lines from spontaneous tumors in FVB/N mice.
Comparative medicine 2008;58(3):253-63.
2008: Satoshi Nagano; Jean Yannis Perentes; Rakesh K Jain; Yves Boucher
Cancer cell death enhances the penetration and efficacy of oncolytic herpes simplex virus in tumors.
Cancer research 2008;68(10):3795-802.
2008: Patrick Au; Joshua Tam; Dai Fukumura; Rakesh K Jain
Bone marrow-derived mesenchymal stem cells facilitate engineering of long-lasting functional vasculature.
Blood 2008;111(9):4551-8.
2008: Rakesh K Jain
Lessons from multidisciplinary translational trials on anti-angiogenic therapy of cancer.
Nature reviews. Cancer 2008;8(4):309-16.
2008: Satoshi Kashiwagi; Kosuke Tsukada; Lei Xu; Junichi Miyazaki; Sergey V Kozin; James A Tyrrell; William C Sessa; Leo E Gerweck; Rakesh K Jain; Dai Fukumura
Perivascular nitric oxide gradients normalize tumor vasculature.
Nature medicine 2008;14(3):255-7.
2008: Patrick Au; Laurence M Daheron; Dan G Duda; Kenneth S Cohen; James A Tyrrell; Ryan M Lanning; Dai Fukumura; David T Scadden; Rakesh K Jain
Differential in vivo potential of endothelial progenitor cells from human umbilical cord blood and adult peripheral blood to form functional long-lasting vessels.
Blood 2008;111(3):1302-5.
2008: Rakesh K Jain; Johanna Lahdenranta; Dai Fukumura
Targeting PDGF signaling in carcinoma-associated fibroblasts controls cervical cancer in mouse model.
PLoS medicine 2008;5(1):e24.
2007: Gregory M Nelson; Timothy P Padera; Igor Garkavtsev; Toshi Shioda; Rakesh K Jain
Differential gene expression of primary cultured lymphatic and blood vascular endothelial cells.
Neoplasia (New York, N.Y.) 2007;9(12):1038-45.
2007: Elizabeth R Gerstner; Dan G Duda; Emmanuelle di Tomaso; Greg Sorensen; Rakesh K Jain; Tracy T Batchelor
Antiangiogenic agents for the treatment of glioblastoma.
Expert opinion on investigational drugs 2007;16(12):1895-908.
2007: Chenghai Sun; Rakesh K Jain; Lance L Munn
Non-uniform plasma leakage affects local hematocrit and blood flow: implications for inflammation and tumor perfusion.
Annals of biomedical engineering 2007;35(12):2121-9.
2007: Wilson Mok; Yves Boucher; Rakesh K Jain
Matrix metalloproteinases-1 and -8 improve the distribution and efficacy of an oncolytic virus.
Cancer research 2007;67(22):10664-8.
2007: Rakesh K Jain; Lei Xu
alphaPlGF: a new kid on the antiangiogenesis block.
Cell 2007;131(3):443-5.
2007: Rakesh K Jain; Aloke V Finn; Frank D Kolodgie; Herman K Gold; Renu Virmani
Antiangiogenic therapy for normalization of atherosclerotic plaque vasculature: a potential strategy for plaque stabilization.
Nature clinical practice. Cardiovascular medicine 2007;4(9):491-502.
2007: Lei Xu; Rakesh K Jain
Down-regulation of placenta growth factor by promoter hypermethylation in human lung and colon carcinoma.
Molecular cancer research : MCR 2007;5(9):873-80.
2007: Dai Fukumura; Rakesh K Jain
Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization.
Microvascular research 2007;74(2-3):72-84.
2007: Christopher G Willett; Dan G Duda; Brian G Czito; Johanna C Bendell; jeffrey clark; Rakesh K Jain
Targeted therapy in rectal cancer.
Oncology (Williston Park, N.Y.) 2007;21(9):1055-65; discussion 1065, 1070, 1075 passim.
2007: Rakesh K Jain; Emmanuelle di Tomaso; Dan G Duda; Jay S Loeffler; A Gregory Sorensen; Tracy T Batchelor
Angiogenesis in brain tumours.
Nature reviews. Neuroscience 2007;8(8):610-22.
2007: Dai Fukumura; Rakesh K Jain
Tumor microenvironment abnormalities: causes, consequences, and strategies to normalize.
Journal of cellular biochemistry 2007;101(4):937-49.
2007: Sergey V Kozin; Frank Winkler; Igor Garkavtsev; Daniel J Hicklin; Rakesh K Jain; Yves Boucher
Human tumor xenografts recurring after radiotherapy are more sensitive to anti-vascular endothelial growth factor receptor-2 treatment than treatment-naive tumors.
Cancer research 2007;67(11):5076-82.
2007: Christopher G Willett; Dan G Duda; Emmanuelle di Tomaso; Yves Boucher; Brian G Czito; Zeljko Vujaskovic; Gordana Vlahovic; Johanna C Bendell; Kenneth S Cohen; Herbert I Hurwitz; Rex Bentley; Gregory Y Lauwers; Martin Poleski; Terence Z Wong; erik paulson; Kirk A Ludwig; Rakesh K Jain
Complete pathological response to bevacizumab and chemoradiation in advanced rectal cancer.
Nature clinical practice. Oncology 2007;4(5):316-21.
2007: Rakesh K Jain; Ricky T Tong; Lance L Munn
Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model.
Cancer research 2007;67(6):2729-35.
2007: Zack Zhengyu Wang; Patrick Au; Tong Chen; Ying Shao; Laurence M Daheron; Hao Bai; Melanie Arzigian; Dai Fukumura; Rakesh K Jain; David T Scadden
Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo.
Nature biotechnology 2007;25(3):317-8.
2007: James Alexander Tyrrell; Emmanuelle di Tomaso; Daniel Fuja; Ricky T Tong; Kevin Kozak; Rakesh K Jain; Badrinath Roysam
Robust 3-D modeling of vasculature imagery using superellipsoids.
IEEE transactions on medical imaging 2007;26(2):223-37.
2007: Patrick Au; Josh Tam; Dai Fukumura; Rakesh K Jain
Small blood vessel engineering.
Methods in molecular medicine 2007;140():183-95.
2007: Dan G Duda; Kenneth S Cohen; David T Scadden; Rakesh K Jain
A protocol for phenotypic detection and enumeration of circulating endothelial cells and circulating progenitor cells in human blood.
Nature protocols 2007;2(4):805-10.
2007: Tracy T Batchelor; A Gregory Sorensen; Emmanuelle di Tomaso; Wei-Ting Zhang; Dan G Duda; Kenneth S Cohen; Kevin R Kozak; Daniel P Cahill; Poe-Jou Chen; Mingwang Zhu; Marek Ancukiewicz; Maciej M Mrugala; Scott Plotkin; Jan Drappatz; David N Louis; Percy Ivy; David T Scadden; Thomas Benner; Jay S Loeffler; Patrick Y Wen; Rakesh K Jain
AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients.
Cancer cell 2007;11(1):83-95.
2006: Jeroen Hagendoorn; Timothy P Padera; Torunn I Yock; G Petur Nielsen; Emmanuelle di Tomaso; Dan G Duda; Thomas F Delaney; Henning A Gaissert; Jennifer Pearce; Andrew E Rosenberg; Rakesh K Jain; David H Ebb
Platelet-derived growth factor receptor-beta in Gorham's disease.
Nature clinical practice. Oncology 2006;3(12):693-7.
2006: Christopher G Willett; Sergey V Kozin; Dan G Duda; Emmanuelle di Tomaso; Kevin R Kozak; Yves Boucher; Rakesh K Jain
Combined vascular endothelial growth factor-targeted therapy and radiotherapy for rectal cancer: theory and clinical practice.
Seminars in oncology 2006;33(5 Suppl 10):S35-40.
2006: Sai T Reddy; David A Berk; Rakesh K Jain; Melody Swartz
A sensitive in vivo model for quantifying interstitial convective transport of injected macromolecules and nanoparticles.
Journal of applied physiology (Bethesda, Md. : 1985) 2006;101(4):1162-9.
2006: Tohru Hoshida; Naohide Isaka; Jeroen Hagendoorn; Emmanuelle di Tomaso; Yen-Lin Chen; Bronislaw Pytowski; Dai Fukumura; Timothy P Padera; Rakesh K Jain
Imaging steps of lymphatic metastasis reveals that vascular endothelial growth factor-C increases metastasis by increasing delivery of cancer cells to lymph nodes: therapeutic implications.
Cancer research 2006;66(16):8065-75.
2006: David M Cochran; Dai Fukumura; Marek Ancukiewicz; Peter Carmeliet; Rakesh K Jain
Evolution of oxygen and glucose concentration profiles in a tissue-mimetic culture system of embryonic stem cells.
Annals of biomedical engineering 2006;34(8):1247-58.
2006: Dai Fukumura; Satoshi Kashiwagi; Rakesh K Jain
The role of nitric oxide in tumour progression.
Nature reviews. Cancer 2006;6(7):521-34.
2006: Lei Xu; David M Cochran; Ricky T Tong; Frank Winkler; Satoshi Kashiwagi; Rakesh K Jain; Dai Fukumura
Placenta growth factor overexpression inhibits tumor growth, angiogenesis, and metastasis by depleting vascular endothelial growth factor homodimers in orthotopic mouse models.
Cancer research 2006;66(8):3971-7.
2006: Jeroen Hagendoorn; Ricky Tong; Dai Fukumura; Qingcong Lin; Jennifer Lobo; Timothy P Padera; Lei Xu; Raju Kucherlapati; Rakesh K Jain
Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesis.
Cancer research 2006;66(7):3360-4.
2006: Dan G Duda; Kenneth S Cohen; Sergey V Kozin; Jean Y Perentes; Dai Fukumura; David T Scadden; Rakesh K Jain
Evidence for incorporation of bone marrow-derived endothelial cells into perfused blood vessels in tumors.
Blood 2006;107(7):2774-6.
2006: Dan G Duda; Kenneth S Cohen; Emmanuelle di Tomaso; Patrick Au; Rachael J Klein; David T Scadden; Christopher G Willett; Rakesh K Jain
Differential CD146 expression on circulating versus tissue endothelial cells in rectal cancer patients: implications for circulating endothelial and progenitor cells as biomarkers for antiangiogenic therapy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(9):1449-53.
2006: Trevor McKee; Paola Grandi; Wilson Mok; Georgios Alexandrakis; Numpon Insin; John P Zimmer; Moungi G Bawendi; Yves Boucher; Xandra O Breakefield; Rakesh K Jain
Degradation of fibrillar collagen in a human melanoma xenograft improves the efficacy of an oncolytic herpes simplex virus vector.
Cancer research 2006;66(5):2509-13.
2006: Janka Kisucka; Catherine E Butterfield; Dan G Duda; Sarah C Eichenberger; Simin Saffaripour; Jerry Ware; Zaverio M Ruggeri; Rakesh K Jain; Judah Folkman; Denisa D Wagner
Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(4):855-60.
2006: Rakesh K Jain; Dan G Duda; jeffrey clark; Jay S Loeffler
Lessons from phase III clinical trials on anti-VEGF therapy for cancer.
Nature clinical practice. Oncology 2006;3(1):24-40.
2005: Christopher G Willett; Yves Boucher; Dan G Duda; Emmanuelle di Tomaso; Lance L Munn; Ricky T Tong; Sergey V Kozin; Lucine Petit; Rakesh K Jain; Daniel C Chung; Dushyant V Sahani; Sanjeeva Kalva; Kenneth S Cohen; David T Scadden; Alan J Fischman; jeffrey clark; David P Ryan; Andrew X Zhu; Lawrence S Blaszkowsky; Paul C Shellito; Mari Mino-Kenudson; Gregory Y Lauwers
Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(31):8136-9.
2005: James Alexander Tyrrell; Vijay Mahadevan; Ricky T Tong; Edward B Brown; Rakesh K Jain; Badrinath Roysam
A 2-D/3-D model-based method to quantify the complexity of microvasculature imaged by in vivo multiphoton microscopy.
Microvascular research 2005;70(3):165-78.
2005: Jeroen Hagendoorn; Timothy P Padera; Dai Fukumura; Rakesh K Jain
Molecular regulation of microlymphatic formation and function: role of nitric oxide.
Trends in cardiovascular medicine 2005;15(5):169-73.
2005: Rakesh K Jain; Patrick Au; Josh Tam; Dan G Duda; Dai Fukumura
Engineering vascularized tissue.
Nature biotechnology 2005;23(7):821-3.
2005: Emmanuelle di Tomaso; Diane Capen; Amy Haskell; Janet Hart; James J Logie; Rakesh K Jain; Donald M McDonald; Rosemary Jones; Lance L Munn
Mosaic tumor vessels: cellular basis and ultrastructure of focal regions lacking endothelial cell markers.
Cancer research 2005;65(13):5740-9.
2005: Lei Xu; Ricky T Tong; David M Cochran; Rakesh K Jain
Blocking platelet-derived growth factor-D/platelet-derived growth factor receptor beta signaling inhibits human renal cell carcinoma progression in an orthotopic mouse model.
Cancer research 2005;65(13):5711-9.
2005: Zoe N Demou; Michael Awad; Trevor McKee; Jean Yannis Perentes; Xiaoye Wang; Lance L Munn; Rakesh K Jain; Yves Boucher
Lack of telopeptides in fibrillar collagen I promotes the invasion of a metastatic breast tumor cell line.
Cancer research 2005;65(13):5674-82.
2005: Satoshi Kashiwagi; Yotaro Izumi; Takeshi Gohongi; Zoe N Demou; Lei Xu; Paul L Huang; Donald G Buerk; Lance L Munn; Rakesh K Jain; Dai Fukumura
NO mediates mural cell recruitment and vessel morphogenesis in murine melanomas and tissue-engineered blood vessels.
The Journal of clinical investigation 2005;115(7):1816-27.
2005: Peigen Huang; Trevor McKee; Rakesh K Jain; Dai Fukumura
Green fluorescent protein (GFP)-expressing tumor model derived from a spontaneous osteosarcoma in a vascular endothelial growth factor (VEGF)-GFP transgenic mouse.
Comparative medicine 2005;55(3):236-43.
2005: Mark Stroh; John P Zimmer; Dan G Duda; Tatyana S Levchenko; Kenneth S Cohen; Edward B Brown; David T Scadden; Vladimir P Torchilin; Moungi G Bawendi; Dai Fukumura; Rakesh K Jain
Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo.
Nature medicine 2005;11(6):678-82.
2005: Dan G Duda; Rakesh K Jain
Pleiotropy of tissue-specific growth factors: from neurons to vessels via the bone marrow.
The Journal of clinical investigation 2005;115(3):596-8.
2005: Rakesh K Jain
Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy.
Science (New York, N.Y.) 2005;307(5706):58-62.
2004: Frank Winkler; Sergey V Kozin; Ricky T Tong; Sung-Suk Chae; Michael F Booth; Igor Garkavtsev; Lei Xu; Daniel J Hicklin; Dai Fukumura; Emmanuelle di Tomaso; Lance L Munn; Rakesh K Jain
Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases.
Cancer cell 2004;6(6):553-63.
2004: Dan G Duda; Dai Fukumura; Lance L Munn; Michael F Booth; Edward B Brown; Peigen Huang; Brian Seed; Rakesh K Jain
Differential transplantability of tumor-associated stromal cells.
Cancer research 2004;64(17):5920-4.
2004: Jeroen Hagendoorn; Timothy P Padera; Satoshi Kashiwagi; Naohide Isaka; Fatima Noda; Michelle I Lin; Paul L Huang; William C Sessa; Dai Fukumura; Rakesh K Jain
Endothelial nitric oxide synthase regulates microlymphatic flow via collecting lymphatics.
Circulation research 2004;95(2):204-9.
2004: Naohide Isaka; Timothy P Padera; Jeroen Hagendoorn; Dai Fukumura; Rakesh K Jain
Peritumor lymphatics induced by vascular endothelial growth factor-C exhibit abnormal function.
Cancer research 2004;64(13):4400-4.
2004: Ricky T Tong; Yves Boucher; Sergey V Kozin; Frank Winkler; Daniel J Hicklin; Rakesh K Jain
Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors.
Cancer research 2004;64(11):3731-6.
2004: Edward B Brown; Yves Boucher; Selim Nasser; Rakesh K Jain
Measurement of macromolecular diffusion coefficients in human tumors.
Microvascular research 2004;67(3):231-6.
2004: Dan G Duda; Dai Fukumura; Rakesh K Jain
Role of eNOS in neovascularization: NO for endothelial progenitor cells.
Trends in molecular medicine 2004;10(4):143-5.
2004: Maximilian Bockhorn; Sylvie Roberge; Cristina Sousa; Rakesh K Jain; Lance L Munn
Differential gene expression in metastasizing cells shed from kidney tumors.
Cancer research 2004;64(7):2469-73.
2004: Takeshi Gohongi; Takeshi Todoroki; Dai Fukumura; Rakesh K Jain
Influence of the site of human gallbladder xenograft (Mz-ChA-1) on angiogenesis at the distant site.
Oncology reports 2004;11(4):803-7.
2004: Igor Garkavtsev; Sergey V Kozin; Olga Chernova; Lei Xu; Frank Winkler; Edward Brown; Gene H Barnett; Rakesh K Jain
The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis.
Nature 2004;428(6980):328-32.
2004: Naoto Koike; Dai Fukumura; Oliver Gralla; Patrick Au; Jeffrey S Schechner; Rakesh K Jain
Tissue engineering: creation of long-lasting blood vessels.
Nature 2004;428(6979):138-9.
2004: Timothy P Padera; Brian R Stoll; Jessica B Tooredman; Diane Capen; Emmanuelle di Tomaso; Rakesh K Jain
Pathology: cancer cells compress intratumour vessels.
Nature 2004;427(6976):695.
2004: Christopher G Willett; Yves Boucher; Emmanuelle di Tomaso; Dan G Duda; Lance L Munn; Ricky T Tong; Daniel C Chung; Dushyant V Sahani; Sanjeeva Kalva; Sergey V Kozin; Mari Mino; Kenneth S Cohen; David T Scadden; Alan C Hartford; Alan J Fischman; jeffrey clark; David P Ryan; Andrew X Zhu; Lawrence S Blaszkowsky; Helen X Chen; Paul C Shellito; Gregory Y Lauwers; Rakesh K Jain
Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer.
Nature medicine 2004;10(2):145-7.
2004: Georgios Alexandrakis; Edward B Brown; Ricky T Tong; Trevor McKee; Robert B Campbell; Yves Boucher; Rakesh K Jain
Two-photon fluorescence correlation microscopy reveals the two-phase nature of transport in tumors.
Nature medicine 2004;10(2):203-7.
2003: Tiina Roose; Paolo A Netti; Lance L Munn; Yves Boucher; Rakesh K Jain
Solid stress generated by spheroid growth estimated using a linear poroelasticity model small star, filled.
Microvascular research 2003;66(3):204-12.
2003: Dai Fukumura; Akira Ushiyama; Dan G Duda; Lei Xu; Josh Tam; V Krishna; K Chatterjee; Igor Garkavtsev; Rakesh K Jain
Paracrine regulation of angiogenesis and adipocyte differentiation during in vivo adipogenesis.
Circulation research 2003;93(9):e88-97.
2003: Rakesh K Jain; Michael F Booth
What brings pericytes to tumor vessels?
The Journal of clinical investigation 2003;112(8):1134-6.
2003: Brian R Stoll; Cristiano Migliorini; Ananth Kadambi; Lance L Munn; Rakesh K Jain
A mathematical model of the contribution of endothelial progenitor cells to angiogenesis in tumors: implications for antiangiogenic therapy.
Blood 2003;102(7):2555-61.
2003: Neil S Forbes; Lance L Munn; Dai Fukumura; Rakesh K Jain
Sparse initial entrapment of systemically injected Salmonella typhimurium leads to heterogeneous accumulation within tumors.
Cancer research 2003;63(17):5188-93.
2003: Muhammad-Amri Abdul-Karim; Khalid A Al-Kofahi; Edward B Brown; Rakesh K Jain; Badrinath Roysam
Automated tracing and change analysis of angiogenic vasculature from in vivo multiphoton confocal image time series.
Microvascular research 2003;66(2):113-25.
2003: Rakesh K Jain
Molecular regulation of vessel maturation.
Nature medicine 2003;9(6):685-93.
2003: Edward Brown; Trevor McKee; Emmanuelle diTomaso; Alain Pluen; Brian Seed; Yves Boucher; Rakesh K Jain
Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation.
Nature medicine 2003;9(6):796-800.
2003: Dennis E J G J Dolmans; Dai Fukumura; Rakesh K Jain
Photodynamic therapy for cancer.
Nature reviews. Cancer 2003;3(5):380-7.
2003: Yotaro Izumi; Emmanuelle di Tomaso; Andrea Hooper; Peigen Huang; James Huber; Daniel J Hicklin; Dai Fukumura; Rakesh K Jain; Herman D Suit
Responses to antiangiogenesis treatment of spontaneous autochthonous tumors and their isografts.
Cancer research 2003;63(4):747-51.
2003: Rakesh K Jain; Timothy P Padera
Development. Lymphatics make the break.
Science (New York, N.Y.) 2003;299(5604):209-10.
2002: Rakesh K Jain
Tumor angiogenesis and accessibility: role of vascular endothelial growth factor.
Seminars in oncology 2002;29(6 Suppl 16):3-9.
2002: Robert B Campbell; Dai Fukumura; Edward B Brown; Laureen M Mazzola; Yotaro Izumi; Rakesh K Jain; Vladimir P Torchilin; Lance L Munn
Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors.
Cancer research 2002;62(23):6831-6.
2002: Cristiano Migliorini; YueHong Qian; Hudong Chen; Edward B Brown; Rakesh K Jain; Lance L Munn
Red blood cells augment leukocyte rolling in a virtual blood vessel.
Biophysical journal 2002;83(4):1834-41.
2002: Saroja Ramanujan; Alain Pluen; Trevor McKee; Edward B Brown; Yves Boucher; Rakesh K Jain
Diffusion and convection in collagen gels: implications for transport in the tumor interstitium.
Biophysical journal 2002;83(3):1650-60.
2002: Stuart W Friedrich; Stephany C Lin; Brian R Stoll; Laurence T Baxter; Lance L Munn; Rakesh K Jain
Antibody-directed effector cell therapy of tumors: analysis and optimization using a physiologically based pharmacokinetic model.
Neoplasia (New York, N.Y.) 2002;4(5):449-63.
2002: Dennis E J G J Dolmans; Ananth Kadambi; John S Hill; Kevin R Flores; Joseph N Gerber; Jeffrey P Walker; Inne H M Borel Rinkes; Rakesh K Jain; Dai Fukumura
Targeting tumor vasculature and cancer cells in orthotopic breast tumor by fractionated photosensitizer dosing photodynamic therapy.
Cancer research 2002;62(15):4289-94.
2002: Timothy P Padera; Ananth Kadambi; Emmanuelle di Tomaso; Carla Mouta Carreira; Edward B Brown; Yves Boucher; Noah C Choi; Douglas J Mathisen; John Wain; Eugene J Mark; Lance L Munn; Rakesh K Jain
Lymphatic metastasis in the absence of functional intratumor lymphatics.
Science (New York, N.Y.) 2002;296(5574):1883-6.
2002: C de L Davies; David A Berk; Alain Pluen; Rakesh K Jain
Comparison of IgG diffusion and extracellular matrix composition in rhabdomyosarcomas grown in mice versus in vitro as spheroids reveals the role of host stromal cells.
British journal of cancer 2002;86(10):1639-44.
2002: Rakesh K Jain; Lance L Munn; Dai Fukumura
Dissecting tumour pathophysiology using intravital microscopy.
Nature reviews. Cancer 2002;2(4):266-76.
2002: Gabriel Helmlinger; Axel Sckell; Marc Dellian; Neil S Forbes; Rakesh K Jain
Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(4):1284-91.
2002: Wayne L Monsky; Carla Mouta Carreira; Yoshikazu Tsuzuki; Takeshi Gohongi; Dai Fukumura; Rakesh K Jain
Role of host microenvironment in angiogenesis and microvascular functions in human breast cancer xenografts: mammary fat pad versus cranial tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(4):1008-13.
2002: Dennis E J G J Dolmans; Ananth Kadambi; John S Hill; Christina A Waters; Byron C Robinson; Jeffrey P Walker; Dai Fukumura; Rakesh K Jain
Vascular accumulation of a novel photosensitizer, MV6401, causes selective thrombosis in tumor vessels after photodynamic therapy.
Cancer research 2002;62(7):2151-6.
2002: Lei Xu; Dai Fukumura; Rakesh K Jain
Acidic extracellular pH induces vascular endothelial growth factor (VEGF) in human glioblastoma cells via ERK1/2 MAPK signaling pathway: mechanism of low pH-induced VEGF.
The Journal of biological chemistry 2002;277(13):11368-74.
2002: Yotaro Izumi; Lei Xu; Emmanuelle di Tomaso; Dai Fukumura; Rakesh K Jain
Tumour biology: herceptin acts as an anti-angiogenic cocktail.
Nature 2002;416(6878):279-80.
2002: Rakesh K Jain; Brenda T Fenton
Intratumoral lymphatic vessels: a case of mistaken identity or malfunction?
Journal of the National Cancer Institute 2002;94(6):417-21.
2002: Chieko Koike; Trevor McKee; Alain Pluen; Saroja Ramanujan; K Burton; Lance L Munn; Yves Boucher; Rakesh K Jain
Solid stress facilitates spheroid formation: potential involvement of hyaluronan.
British journal of cancer 2002;86(6):947-53.
2002: Timothy P Padera; Brian R Stoll; Peter So; Rakesh K Jain
Conventional and high-speed intravital multiphoton laser scanning microscopy of microvasculature, lymphatics, and leukocyte-endothelial interactions.
Molecular imaging 2002;1(1):9-15.
2002: Rakesh K Jain
Angiogenesis and lymphangiogenesis in tumors: insights from intravital microscopy.
Cold Spring Harbor symposia on quantitative biology 2002;67():239-48.
2002: Robert J Melder; Lance L Munn; Brian R Stoll; Edgardo M Marecos; Laurence T Baxter; Ralph Weissleder; Rakesh K Jain
Systemic distribution and tumor localization of adoptively transferred lymphocytes in mice: comparison with physiologically based pharmacokinetic model.
Neoplasia (New York, N.Y.) 2002;4(1):3-8.
2001: Rakesh K Jain; N S Forbes
Can engineered bacteria help control cancer?
Proceedings of the National Academy of Sciences of the United States of America 2001;98(26):14748-50.
2001: Carla Mouta Carreira; S M Nasser; Emmanuelle di Tomaso; Timothy P Padera; Yves Boucher; S I Tomarev; Rakesh K Jain
LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis.
Cancer research 2001;61(22):8079-84.
2001: S Patan; S Tanda; Sylvie Roberge; Rosemary C Jones; Rakesh K Jain; Lance L Munn
Vascular morphogenesis and remodeling in a human tumor xenograft: blood vessel formation and growth after ovariectomy and tumor implantation.
Circulation research 2001;89(8):732-9.
2001: S Patan; Lance L Munn; S Tanda; Sylvie Roberge; Rakesh K Jain; Rosemary C Jones
Vascular morphogenesis and remodeling in a model of tissue repair: blood vessel formation and growth in the ovarian pedicle after ovariectomy.
Circulation research 2001;89(8):723-31.
2001: Yoshikazu Tsuzuki; Carla Mouta Carreira; Maximilian Bockhorn; L Xu; Rakesh K Jain; Dai Fukumura
Pancreas microenvironment promotes VEGF expression and tumor growth: novel window models for pancreatic tumor angiogenesis and microcirculation.
Laboratory investigation; a journal of technical methods and pathology 2001;81(10):1439-51.
2001: Dai Fukumura; Lei Xu; Yidong Chen; Takeshi Gohongi; Brian Seed; Rakesh K Jain
Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo.
Cancer research 2001;61(16):6020-4.
2001: Rakesh K Jain
Delivery of molecular medicine to solid tumors: lessons from in vivo imaging of gene expression and function.
Journal of controlled release : official journal of the Controlled Release Society 2001;74(1-3):7-25.
2001: Edward B Brown; Robert B Campbell; Y Tsuzuki; L Xu; Peter Carmeliet; Dai Fukumura; Rakesh K Jain
In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy.
Nature medicine 2001;7(7):864-8.
2001: Rakesh K Jain
Clearing the smoke on nicotine and angiogenesis.
Nature medicine 2001;7(7):775-7.
2001: C de L Davies; Robert J Melder; Lance L Munn; Carla Mouta Carreira; Rakesh K Jain; Yves Boucher
Decorin inhibits endothelial migration and tube-like structure formation: role of thrombospondin-1.
Microvascular research 2001;62(1):26-42.
2001: Alain Pluen; Yves Boucher; Saroja Ramanujan; Trevor McKee; Takeshi Gohongi; Emmanuelle di Tomaso; Edward B Brown; Yotaro Izumi; Robert B Campbell; David A Berk; Rakesh K Jain
Role of tumor-host interactions in interstitial diffusion of macromolecules: cranial vs. subcutaneous tumors.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(8):4628-33.
2001: Ananth Kadambi; Carla Mouta Carreira; CO Yun; Timothy P Padera; Dennis E J G J Dolmans; Peter Carmeliet; Dai Fukumura; Rakesh K Jain
Vascular endothelial growth factor (VEGF)-C differentially affects tumor vascular function and leukocyte recruitment: role of VEGF-receptor 2 and host VEGF-A.
Cancer research 2001;61(6):2404-8.
2001: Randal O Dull; Junying Yuan; YS Chang; John M Tarbell; Rakesh K Jain; Lance L Munn
Kinetics of placenta growth factor/vascular endothelial growth factor synergy in endothelial hydraulic conductivity and proliferation.
Microvascular research 2001;61(2):203-10.
2001: Dai Fukumura; Takeshi Gohongi; Ananth Kadambi; Yotaro Izumi; J Ang; CO Yun; Donald G Buerk; Paul L Huang; Rakesh K Jain
Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2604-9.
2001: J Yuan; Robert J Melder; Rakesh K Jain; Lance L Munn
Lateral view flow system for studies of cell adhesion and deformation under flow conditions.
BioTechniques 2001;30(2):388-94.
2001: Robert J Melder; CA Kristensen; Lance L Munn; Rakesh K Jain
Modulation of A-NK cell rigidity: In vitro characterization and in vivo implications for cell delivery.
Biorheology 2001;38(2-3):151-9.
2001: Sergey V Kozin; Yves Boucher; Daniel J Hicklin; P Bohlen; Rakesh K Jain; Herman D Suit
Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts.
Cancer research 2001;61(1):39-44.
2000: Y S Chang; Emmanuelle di Tomaso; Donald M McDonald; Rosemary Jones; Rakesh K Jain; Lance L Munn
Mosaic blood vessels in tumors: frequency of cancer cells in contact with flowing blood.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(26):14608-13.
2000: Y Tsuzuki; Dai Fukumura; B Oosthuyse; Chieko Koike; Peter Carmeliet; Rakesh K Jain
Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1alpha--> hypoxia response element--> VEGF cascade differentially regulates vascular response and growth rate in tumors.
Cancer research 2000;60(22):6248-52.
2000: C G Lee; M Heijn; Emmanuelle di Tomaso; G Griffon-Etienne; Marek Ancukiewicz; Chieko Koike; K R Park; Napoleone Ferrara; Rakesh K Jain; Herman D Suit; Yves Boucher
Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions.
Cancer research 2000;60(19):5565-70.
2000: N Hansen-Algenstaedt; Brian R Stoll; Timothy P Padera; Dennis E J G J Dolmans; Daniel J Hicklin; Dai Fukumura; Rakesh K Jain
Tumor oxygenation in hormone-dependent tumors during vascular endothelial growth factor receptor-2 blockade, hormone ablation, and chemotherapy.
Cancer research 2000;60(16):4556-60.
2000: A J Leu; David A Berk; A Lymboussaki; Kari Alitalo; Rakesh K Jain
Absence of functional lymphatics within a murine sarcoma: a molecular and functional evaluation.
Cancer research 2000;60(16):4324-7.
2000: M Stohrer; Yves Boucher; Manfred Stangassinger; Rakesh K Jain
Oncotic pressure in solid tumors is elevated.
Cancer research 2000;60(15):4251-5.
2000: Gabriel Helmlinger; M Endo; Napoleone Ferrara; L Hlatky; Rakesh K Jain
Formation of endothelial cell networks.
Nature 2000;405(6783):139-41.
2000: Paolo A Netti; David A Berk; Melody Swartz; Alan J Grodzinsky; Rakesh K Jain
Role of extracellular matrix assembly in interstitial transport in solid tumors.
Cancer research 2000;60(9):2497-503.
2000: Alan C Hartford; Takeshi Gohongi; Dai Fukumura; Rakesh K Jain
Irradiation of a primary tumor, unlike surgical removal, enhances angiogenesis suppression at a distal site: potential role of host-tumor interaction.
Cancer research 2000;60(8):2128-31.
2000: Saroja Ramanujan; G C Koenig; Timothy P Padera; Brian R Stoll; Rakesh K Jain
Local imbalance of proangiogenic and antiangiogenic factors: a potential mechanism of focal necrosis and dormancy in tumors.
Cancer research 2000;60(5):1442-8.
2000: Robert J Melder; Junying Yuan; Lance L Munn; Rakesh K Jain
Erythrocytes enhance lymphocyte rolling and arrest in vivo.
Microvascular research 2000;59(2):316-22.
2000: YS Chang; Lance L Munn; Mechteld V Hillsley; Randal O Dull; Junying Yuan; S Lakshminarayanan; Thomas Gardner; Rakesh K Jain; John M Tarbell
Effect of vascular endothelial growth factor on cultured endothelial cell monolayer transport properties.
Microvascular research 2000;59(2):265-77.
1999: CA Kristensen; Leena M Hamberg; George J Hunter; Sylvie Roberge; D Kierstead; G L Wolf; Rakesh K Jain
Changes in vascularization of human breast cancer xenografts responding to antiestrogen therapy.
Neoplasia (New York, N.Y.) 1999;1(6):518-25.
1999: Melody Swartz; A Kaipainen; Paolo A Netti; C Brekken; Yves Boucher; Alan J Grodzinsky; Rakesh K Jain
Mechanics of interstitial-lymphatic fluid transport: theoretical foundation and experimental validation.
Journal of biomechanics 1999;32(12):1297-307.
1999: Melody Swartz; CA Kristensen; Robert J Melder; Sylvie Roberge; E Calautti; Dai Fukumura; Rakesh K Jain
Cells shed from tumours show reduced clonogenicity, resistance to apoptosis, and in vivo tumorigenicity.
British journal of cancer 1999;81(5):756-9.
1999: Takeshi Gohongi; Dai Fukumura; Yves Boucher; CO Yun; Gerald A Soff; Carolyn Corlies Compton; Takeshi Todoroki; Rakesh K Jain
Tumor-host interactions in the gallbladder suppress distal angiogenesis and tumor growth: involvement of transforming growth factor beta1.
Nature medicine 1999;5(10):1203-8.
1999: M Heijn; Sylvie Roberge; Rakesh K Jain
Cellular membrane permeability of anthracyclines does not correlate with their delivery in a tissue-isolated tumor.
Cancer research 1999;59(17):4458-63.
1999: M Endo; Rakesh K Jain; B Witwer; D Brown
Water channel (aquaporin 1) expression and distribution in mammary carcinomas and glioblastomas.
Microvascular research 1999;58(2):89-98.
1999: Wayne L Monsky; Dai Fukumura; Takeshi Gohongi; M Ancukiewcz; H A Weich; Vladimir P Torchilin; F Yuan; Rakesh K Jain
Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor.
Cancer research 1999;59(16):4129-35.
1999: G Griffon-Etienne; Yves Boucher; C Brekken; Herman D Suit; Rakesh K Jain
Taxane-induced apoptosis decompresses blood vessels and lowers interstitial fluid pressure in solid tumors: clinical implications.
Cancer research 1999;59(15):3776-82.
1999: Alain Pluen; Paolo A Netti; Rakesh K Jain; David A Berk
Diffusion of macromolecules in agarose gels: comparison of linear and globular configurations.
Biophysical journal 1999;77(1):542-52.
1999: H C Lichtenbeld; N Ferarra; Rakesh K Jain; Lance L Munn
Effect of local anti-VEGF antibody treatment on tumor microvessel permeability.
Microvascular research 1999;57(3):357-62.
1999: Paolo A Netti; Leena M Hamberg; John W Babich; D Kierstead; W Graham; George J Hunter; G L Wolf; Alan J Fischman; Yves Boucher; Rakesh K Jain
Enhancement of fluid filtration across tumor vessels: implication for delivery of macromolecules.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(6):3137-42.
1999: Rakesh K Jain; Lance L Munn; Dai Fukumura; Robert J Melder
In vitro and in vivo quantification of adhesion between leukocytes and vascular endothelium.
Methods in molecular medicine 1999;18():553-75.
1999: CA Kristensen; Nadir Askenasy; Rakesh K Jain; Alan Koretsky
Creatine and cyclocreatine treatment of human colon adenocarcinoma xenografts: 31P and 1H magnetic resonance spectroscopic studies.
British journal of cancer 1999;79(2):278-85.
1998: Axel Sckell; N Safabakhsh; Marc Dellian; Rakesh K Jain
Primary tumor size-dependent inhibition of angiogenesis at a secondary site: an intravital microscopic study in mice.
Cancer research 1998;58(24):5866-9.
1998: Yves Boucher; C Brekken; Paolo A Netti; L T Baxter; Rakesh K Jain
Intratumoral infusion of fluid: estimation of hydraulic conductivity and implications for the delivery of therapeutic agents.
British journal of cancer 1998;78(11):1442-8.
1998: Dai Fukumura; R Xavier; T Sugiura; Y Chen; E C Park; N Lu; M Selig; G Nielsen; T Taksir; Rakesh K Jain; Brian Seed
Tumor induction of VEGF promoter activity in stromal cells.
Cell 1998;94(6):715-25.
1998: Rakesh K Jain; N Safabakhsh; Axel Sckell; Yidong Chen; P Jiang; L Benjamin; F Yuan; E Keshet
Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: role of vascular endothelial growth factor.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(18):10820-5.
1998: Rakesh K Jain
The next frontier of molecular medicine: delivery of therapeutics.
Nature medicine 1998;4(6):655-7.
1998: Rakesh K Jain
Delivery of molecular and cellular medicine to solid tumors.
Journal of controlled release : official journal of the Controlled Release Society 1998;53(1-3):49-67.
1998: S K Hobbs; Wayne L Monsky; F Yuan; W G Roberts; L Griffith; Vladimir P Torchilin; Rakesh K Jain
Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(8):4607-12.
1998: Uwe O.P. Joseph Schoepf; Edgardo M Marecos; Robert J Melder; Rakesh K Jain; Ralph Weissleder
Intracellular magnetic labeling of lymphocytes for in vivo trafficking studies.
BioTechniques 1998;24(4):642-6, 648-51.
1998: D Fukumura; Rakesh K Jain
Role of nitric oxide in angiogenesis and microcirculation in tumors.
Cancer metastasis reviews 1998;17(1):77-89.
1998: David S Milstone; Dai Fukumura; R C Padgett; Peter E O'Donnell; Vannessa M Davis; O J Benavidez; Wayne L Monsky; Robert J Melder; Rakesh K Jain; Michael A Gimbrone
Mice lacking E-selectin show normal numbers of rolling leukocytes but reduced leukocyte stable arrest on cytokine-activated microvascular endothelium.
Microcirculation (New York, N.Y. : 1994) 1998;5(2-3):153-71.
1998: H Zhu; Rakesh K Jain; Laurence T Baxter
Tumor pretargeting for radioimmunodetection and radioimmunotherapy.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1998;39(1):65-76.
1997: Y Gazit; J W Baish; N Safabakhsh; M Leunig; L T Baxter; Rakesh K Jain
Fractal characteristics of tumor vascular architecture during tumor growth and regression.
Microcirculation (New York, N.Y. : 1994) 1997;4(4):395-402.
1997: Rakesh K Jain; Karlheinz Schlenger; Michael Höckel; F Yuan
Quantitative angiogenesis assays: progress and problems.
Nature medicine 1997;3(11):1203-8.
1997: G Griffon-Etienne; Yves Boucher; Rakesh K Jain; Herman D Suit
Effects of needle insertion in tumors on interstitial fluid pressure.
Microvascular research 1997;54(2):174-7.
1997: M Nozue; I Lee; F Yuan; B A Teicher; David M. Brizel; Mark Dewhirst; C G Milross; L Milas; C W Song; C D Thomas; M Guichard; S M Evans; C J Koch; E M Lord; Rakesh K Jain; Herman D Suit
Interlaboratory variation in oxygen tension measurement by Eppendorf "Histograph" and comparison with hypoxic marker.
Journal of surgical oncology 1997;66(1):30-8.
1997: Dai Fukumura; F Yuan; Wayne L Monsky; Yidong Chen; Rakesh K Jain
Effect of host microenvironment on the microcirculation of human colon adenocarcinoma.
The American journal of pathology 1997;151(3):679-88.
1997: Gabriel Helmlinger; Paolo A Netti; H C Lichtenbeld; Robert J Melder; Rakesh K Jain
Solid stress inhibits the growth of multicellular tumor spheroids.
Nature biotechnology 1997;15(8):778-83.
1997: H Zhu; Laurence T Baxter; Rakesh K Jain
Potential and limitations of radioimmunodetection and radioimmunotherapy with monoclonal antibodies.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1997;38(5):731-41.
1997: David A Berk; F Yuan; M Leunig; Rakesh K Jain
Direct in vivo measurement of targeted binding in a human tumor xenograft.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(5):1785-90.
1997: CA Kristensen; Sylvie Roberge; Rakesh K Jain
Effect of tumor necrosis factor alpha on vascular resistance, nitric oxide production, and glucose and oxygen consumption in perfused tissue-isolated human melanoma xenografts.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(3):319-24.
1997: J W Baish; Paolo A Netti; Rakesh K Jain
Transmural coupling of fluid flow in microcirculatory network and interstitium in tumors.
Microvascular research 1997;53(2):128-41.
1997: Rakesh K Jain
The Eugene M. Landis Award Lecture 1996. Delivery of molecular and cellular medicine to solid tumors.
Microcirculation (New York, N.Y. : 1994) 1997;4(1):1-23.
1997: Dai Fukumura; F Yuan; M Endo; Rakesh K Jain
Role of nitric oxide in tumor microcirculation. Blood flow, vascular permeability, and leukocyte-endothelial interactions.
The American journal of pathology 1997;150(2):713-25.
1997: Gabriel Helmlinger; F Yuan; Marc Dellian; Rakesh K Jain
Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation.
Nature medicine 1997;3(2):177-82.
1997: Yves Boucher; H Salehi; B Witwer; Griffith R Harsh; Rakesh K Jain
Interstitial fluid pressure in intracranial tumours in patients and in rodents.
British journal of cancer 1997;75(6):829-36.
1996: F Yuan; Y Chen; Marc Dellian; N Safabakhsh; N Ferrara; Rakesh K Jain
Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(25):14765-70.
1996: H C Lichtenbeld; F Yuan; C C Michel; Rakesh K Jain
Perfusion of single tumor microvessels: application to vascular permeability measurement.
Microcirculation (New York, N.Y. : 1994) 1996;3(4):349-57.
1996: M E Johnson; David A Berk; Daniel Blankschtein; David E Golan; Rakesh K Jain; Robert Langer
Lateral diffusion of small compounds in human stratum corneum and model lipid bilayer systems.
Biophysical journal 1996;71(5):2656-68.
1996: Marc Dellian; Gabriel Helmlinger; F Yuan; Rakesh K Jain
Fluorescence ratio imaging of interstitial pH in solid tumours: effect of glucose on spatial and temporal gradients.
British journal of cancer 1996;74(8):1206-15.
1996: Yves Boucher; M Leunig; Rakesh K Jain
Tumor angiogenesis and interstitial hypertension.
Cancer research 1996;56(18):4264-6.
1996: Robert J Melder; G C Koenig; B P Witwer; N Safabakhsh; L L Munn; Rakesh K Jain
During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium.
Nature medicine 1996;2(9):992-7.
1996: H Zhu; Robert J Melder; Laurence T Baxter; Rakesh K Jain
Physiologically based kinetic model of effector cell biodistribution in mammals: implications for adoptive immunotherapy.
Cancer research 1996;56(16):3771-81.
1996: M Leunig; F Yuan; David A Berk; L E Gerweck; Rakesh K Jain
Heating or freezing bone. Effects on angiogenesis induction and growth potential in mice.
Acta orthopaedica Scandinavica 1996;67(4):383-8.
1996: CA Kristensen; M Nozue; Yves Boucher; Rakesh K Jain
Reduction of interstitial fluid pressure after TNF-alpha treatment of three human melanoma xenografts.
British journal of cancer 1996;74(4):533-6.
1996: Paolo A Netti; Sylvie Roberge; Yves Boucher; Laurence T Baxter; Rakesh K Jain
Effect of transvascular fluid exchange on pressure-flow relationship in tumors: a proposed mechanism for tumor blood flow heterogeneity.
Microvascular research 1996;52(1):27-46.
1996: L L Munn; Robert J Melder; Rakesh K Jain
Role of erythrocytes in leukocyte-endothelial interactions: mathematical model and experimental validation.
Biophysical journal 1996;71(1):466-78.
1996: Marc Dellian; B P Witwer; H A Salehi; F Yuan; Rakesh K Jain
Quantitation and physiological characterization of angiogenic vessels in mice: effect of basic fibroblast growth factor, vascular endothelial growth factor/vascular permeability factor, and host microenvironment.
The American journal of pathology 1996;149(1):59-71.
1996: Rakesh K Jain; G C Koenig; Marc Dellian; D Fukumura; L L Munn; Robert J Melder
Leukocyte-endothelial adhesion and angiogenesis in tumors.
Cancer metastasis reviews 1996;15(2):195-204.
1996: M Nozue; I Lee; J M Manning; L R Manning; Rakesh K Jain
Oxygenation in tumors by modified hemoglobins.
Journal of surgical oncology 1996;62(2):109-14.
1996: J W Baish; Y Gazit; David A Berk; M Nozue; Laurence T Baxter; Rakesh K Jain
Role of tumor vascular architecture in nutrient and drug delivery: an invasion percolation-based network model.
Microvascular research 1996;51(3):327-46.
1996: S Patan; L L Munn; Rakesh K Jain
Intussusceptive microvascular growth in a human colon adenocarcinoma xenograft: a novel mechanism of tumor angiogenesis.
Microvascular research 1996;51(2):260-72.
1996: C A Znati; M Rosenstein; Yves Boucher; Michael W Epperly; William D Bloomer; Rakesh K Jain
Effect of radiation on interstitial fluid pressure and oxygenation in a human tumor xenograft.
Cancer research 1996;56(5):964-68.
1996: Paul E.G. Kristjansen; Tracey Brown; L A Shipley; Rakesh K Jain
Intratumor pharmacokinetics, flow resistance, and metabolism during gemcitabine infusion in ex vivo perfused human small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(2):359-67.
1996: E M Johnson; David A Berk; Rakesh K Jain; William M Deen
Hindered diffusion in agarose gels: test of effective medium model.
Biophysical journal 1996;70(2):1017-23.
1996: Laurence T Baxter; Rakesh K Jain
Pharmacokinetic analysis of the microscopic distribution of enzyme-conjugated antibodies and prodrugs: comparison with experimental data.
British journal of cancer 1996;73(4):447-56.
1996: Robert J Melder; G C Koenig; L L Munn; Rakesh K Jain
Adhesion of activated natural killer cells to tumor necrosis factor-alpha-treated endothelium under physiological flow conditions.
Natural immunity 1996;15(2-3):154-63.
1996: David A Berk; Melody Swartz; A J Leu; Rakesh K Jain
Transport in lymphatic capillaries. II. Microscopic velocity measurement with fluorescence photobleaching.
The American journal of physiology 1996;270(1 Pt 2):H330-7.
1996: Melody Swartz; David A Berk; Rakesh K Jain
Transport in lymphatic capillaries. I. Macroscopic measurements using residence time distribution theory.
The American journal of physiology 1996;270(1 Pt 2):H324-9.
1995: Paolo A Netti; Laurence T Baxter; Yves Boucher; R Skalak; Rakesh K Jain
Time-dependent behavior of interstitial fluid pressure in solid tumors: implications for drug delivery.
Cancer research 1995;55(22):5451-8.
1995: R A Zlotecki; Laurence T Baxter; Yves Boucher; Rakesh K Jain
Pharmacologic modification of tumor blood flow and interstitial fluid pressure in a human tumor xenograft: network analysis and mechanistic interpretation.
Microvascular research 1995;50(3):429-43.
1995: Robert J Melder; L L Munn; S Yamada; C Ohkubo; Rakesh K Jain
Selectin- and integrin-mediated T-lymphocyte rolling and arrest on TNF-alpha-activated endothelium: augmentation by erythrocytes.
Biophysical journal 1995;69(5):2131-8.
1995: Dai Fukumura; H A Salehi; B Witwer; R F Tuma; Robert J Melder; Rakesh K Jain
Tumor necrosis factor alpha-induced leukocyte adhesion in normal and tumor vessels: effect of tumor type, transplantation site, and host strain.
Cancer research 1995;55(21):4824-9.
1995: S Yamada; T N Mayadas; F Yuan; D D Wagner; R O Hynes; Robert J Melder; Rakesh K Jain
Rolling in P-selectin-deficient mice is reduced but not eliminated in the dorsal skin.
Blood 1995;86(9):3487-92.
1995: Laurence T Baxter; H Zhu; D G Mackensen; W F Butler; Rakesh K Jain
Biodistribution of monoclonal antibodies: scale-up from mouse to human using a physiologically based pharmacokinetic model.
Cancer research 1995;55(20):4611-22.
1995: L L Munn; G C Koenig; Rakesh K Jain; Robert J Melder
Kinetics of adhesion molecule expression and spatial organization using targeted sampling fluorometry.
BioTechniques 1995;19(4):622-6, 628-31.
1995: Yves Boucher; I Lee; Rakesh K Jain
Lack of general correlation between interstitial fluid pressure and oxygen partial pressure in solid tumors.
Microvascular research 1995;50(2):175-82.
1995: F Yuan; Marc Dellian; Dai Fukumura; M Leunig; David A Berk; Vladimir P Torchilin; Rakesh K Jain
Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size.
Cancer research 1995;55(17):3752-6.
1995: Robert J Melder; H A Salehi; Rakesh K Jain
Interaction of activated natural killer cells with normal and tumor vessels in cranial windows in mice.
Microvascular research 1995;50(1):35-44.
1995: E M Johnson; David A Berk; Rakesh K Jain; William M Deen
Diffusion and partitioning of proteins in charged agarose gels.
Biophysical journal 1995;68(4):1561-8.
1995: M Leunig; F Yuan; L E Gerweck; David A Berk; Rakesh K Jain
Quantitative analysis of angiogenesis and growth of bone: effect of indomethacin exposure in a combined in vitro-in vivo approach.
Research in experimental medicine. Zeitschrift für die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie 1995;195(5):275-88.
1994: G R Martin; Rakesh K Jain
Noninvasive measurement of interstitial pH profiles in normal and neoplastic tissue using fluorescence ratio imaging microscopy.
Cancer research 1994;54(21):5670-4.
1994: Paul E.G. Kristjansen; Sylvie Roberge; I Lee; Rakesh K Jain
Tissue-isolated human tumor xenografts in athymic nude mice.
Microvascular research 1994;48(3):389-402.
1994: A J Leu; David A Berk; F Yuan; Rakesh K Jain
Flow velocity in the superficial lymphatic network of the mouse tail.
The American journal of physiology 1994;267(4 Pt 2):H1507-13.
1994: Robert J Melder; David R Elmaleh; Anna-Liisa Brownell; G L Brownell; Rakesh K Jain
A method for labeling cells for positron emission tomography (PET) studies.
Journal of immunological methods 1994;175(1):79-87.
1994: R J Melder; Rakesh K Jain
Reduction of rigidity in human activated natural killer cells by thioglycollate treatment.
Journal of immunological methods 1994;175(1):69-77.
1994: F Yuan; H A Salehi; Yves Boucher; US Vasthare; R F Tuma; Rakesh K Jain
Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows.
Cancer research 1994;54(17):4564-8.
1994: L L Munn; Robert J Melder; Rakesh K Jain
Analysis of cell flux in the parallel plate flow chamber: implications for cell capture studies.
Biophysical journal 1994;67(2):889-95.
1994: M Leunig; F Yuan; David A Berk; L E Gerweck; Rakesh K Jain
Angiogenesis and growth of isografted bone: quantitative in vivo assay in nude mice.
Laboratory investigation; a journal of technical methods and pathology 1994;71(2):300-7.
1994: F Yuan; M Leunig; S K Huang; David A Berk; D Papahadjopoulos; Rakesh K Jain
Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft.
Cancer research 1994;54(13):3352-6.
1994: I Lee; T J Demhartner; Yves Boucher; Rakesh K Jain; M Intaglietta
Effect of hemodilution and resuscitation on tumor interstitial fluid pressure, blood flow, and oxygenation.
Microvascular research 1994;48(1):1-12.
1994: Laurence T Baxter; H Zhu; D G Mackensen; Rakesh K Jain
Physiologically based pharmacokinetic model for specific and nonspecific monoclonal antibodies and fragments in normal tissues and human tumor xenografts in nude mice.
Cancer research 1994;54(6):1517-28.
1994: I Lee; Yves Boucher; T J Demhartner; Rakesh K Jain
Changes in tumour blood flow, oxygenation and interstitial fluid pressure induced by pentoxifylline.
British journal of cancer 1994;69(3):492-6.
1994: C J Eskey; N Wolmark; C L McDowell; M M Domach; Rakesh K Jain
Residence time distributions of various tracers in tumors: implications for drug delivery and blood flow measurement.
Journal of the National Cancer Institute 1994;86(4):293-9.
1993: David A Berk; F Yuan; M Leunig; Rakesh K Jain
Fluorescence photobleaching with spatial Fourier analysis: measurement of diffusion in light-scattering media.
Biophysical journal 1993;65(6):2428-36.
1993: Paul E.G. Kristjansen; Yves Boucher; Rakesh K Jain
Dexamethasone reduces the interstitial fluid pressure in a human colon adenocarcinoma xenograft.
Cancer research 1993;53(20):4764-6.
1993: G R Martin; Rakesh K Jain
Fluorescence ratio imaging measurement of pH gradients: calibration and application in normal and tumor tissues.
Microvascular research 1993;46(2):216-30.
1993: R A Zlotecki; Yves Boucher; I Lee; Laurence T Baxter; Rakesh K Jain
Effect of angiotensin II induced hypertension on tumor blood flow and interstitial fluid pressure.
Cancer research 1993;53(11):2466-8.
1993: F Yuan; M Leunig; David A Berk; Rakesh K Jain
Microvascular permeability of albumin, vascular surface area, and vascular volume measured in human adenocarcinoma LS174T using dorsal chamber in SCID mice.
Microvascular research 1993;45(3):269-89.
1993: C J Eskey; Alan Koretsky; M M Domach; Rakesh K Jain
Role of oxygen vs. glucose in energy metabolism in a mammary carcinoma perfused ex vivo: direct measurement by 31P NMR.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(7):2646-50.
1992: M Leunig; F Yuan; M D Menger; Yves Boucher; Alwin E Goetz; K Messmer; Rakesh K Jain
Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice.
Cancer research 1992;52(23):6553-60.
1992: C J Eskey; Alan Koretsky; M M Domach; Rakesh K Jain
2H-nuclear magnetic resonance imaging of tumor blood flow: spatial and temporal heterogeneity in a tissue-isolated mammary adenocarcinoma.
Cancer research 1992;52(21):6010-9.
1992: E N Kaufman; Rakesh K Jain
In vitro measurement and screening of monoclonal antibody affinity using fluorescence photobleaching.
Journal of immunological methods 1992;155(1):1-17.
1992: Laurence T Baxter; F Yuan; Rakesh K Jain
Pharmacokinetic analysis of the perivascular distribution of bifunctional antibodies and haptens: comparison with experimental data.
Cancer research 1992;52(20):5838-44.
1992: Yves Boucher; Rakesh K Jain
Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse.
Cancer research 1992;52(18):5110-4.
1992: E N Kaufman; Rakesh K Jain
Effect of bivalent interaction upon apparent antibody affinity: experimental confirmation of theory using fluorescence photobleaching and implications for antibody binding assays.
Cancer research 1992;52(15):4157-67.
1992: I Lee; Yves Boucher; Rakesh K Jain
Nicotinamide can lower tumor interstitial fluid pressure: mechanistic and therapeutic implications.
Cancer research 1992;52(11):3237-40.
1991: Yves Boucher; J M Kirkwood; D Opacic; M Desantis; Rakesh K Jain
Interstitial hypertension in superficial metastatic melanomas in humans.
Cancer research 1991;51(24):6691-4.
1991: E N Kaufman; Rakesh K Jain
Measurement of mass transport and reaction parameters in bulk solution using photobleaching. Reaction limited binding regime.
Biophysical journal 1991;60(3):596-610.
1991: F Yuan; Laurence T Baxter; Rakesh K Jain
Pharmacokinetic analysis of two-step approaches using bifunctional and enzyme-conjugated antibodies.
Cancer research 1991;51(12):3119-30.
1991: Eva M Sevick-Muraca; Rakesh K Jain
Effect of red blood cell rigidity on tumor blood flow: increase in viscous resistance during hyperglycemia.
Cancer research 1991;51(10):2727-30.
1991: A Sasaki; R J Melder; T L Whiteside; Ronald Herberman; Rakesh K Jain
Preferential localization of human adherent lymphokine-activated killer cells in tumor microcirculation.
Journal of the National Cancer Institute 1991;83(6):433-7.
1991: Laurence T Baxter; Rakesh K Jain
Transport of fluid and macromolecules in tumors. IV. A microscopic model of the perivascular distribution.
Microvascular research 1991;41(2):252-72.
1991: C Ohkubo; D Bigos; Rakesh K Jain
Interleukin 2 induced leukocyte adhesion to the normal and tumor microvascular endothelium in vivo and its inhibition by dextran sulfate: implications for vascular leak syndrome.
Cancer research 1991;51(5):1561-3.
1991: Eva M Sevick-Muraca; Rakesh K Jain
Measurement of capillary filtration coefficient in a solid tumor.
Cancer research 1991;51(4):1352-5.
1991: Laurence T Baxter; Rakesh K Jain
Transport of fluid and macromolecules in tumors. III. Role of binding and metabolism.
Microvascular research 1991;41(1):5-23.
1990: Rakesh K Jain
Vascular and interstitial barriers to delivery of therapeutic agents in tumors.
Cancer metastasis reviews 1990;9(3):253-66.
1990: E N Kaufman; Rakesh K Jain
Quantification of transport and binding parameters using fluorescence recovery after photobleaching. Potential for in vivo applications.
Biophysical journal 1990;58(4):873-85.
1990: Laurence T Baxter; Rakesh K Jain
Transport of fluid and macromolecules in tumors. II. Role of heterogeneous perfusion and lymphatics.
Microvascular research 1990;40(2):246-63.
1990: Yves Boucher; Laurence T Baxter; Rakesh K Jain
Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy.
Cancer research 1990;50(15):4478-84.
1990: M A Clauss; Rakesh K Jain
Interstitial transport of rabbit and sheep antibodies in normal and neoplastic tissues.
Cancer research 1990;50(12):3487-92.
1990: Rakesh K Jain
Physiological barriers to delivery of monoclonal antibodies and other macromolecules in tumors.
Cancer research 1990;50(3 Suppl):814s-819s.
1990: Rakesh K Jain; R J Stock; S R Chary; M Rueter
Convection and diffusion measurements using fluorescence recovery after photobleaching and video image analysis: in vitro calibration and assessment.
Microvascular research 1990;39(1):77-93.
1990: Rakesh K Jain
Tumor physiology and antibody delivery.
Frontiers of radiation therapy and oncology 1990;24():32-46; discussion 64-8.
1989: A Sasaki; Rakesh K Jain; A A Maghazachi; R H Goldfarb; Ronald Herberman
Low deformability of lymphokine-activated killer cells as a possible determinant of in vivo distribution.
Cancer research 1989;49(14):3742-6.
1989: S R Chary; Rakesh K Jain
Direct measurement of interstitial convection and diffusion of albumin in normal and neoplastic tissues by fluorescence photobleaching.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(14):5385-9.
1989: Eva M Sevick-Muraca; Rakesh K Jain
Viscous resistance to blood flow in solid tumors: effect of hematocrit on intratumor blood viscosity.
Cancer research 1989;49(13):3513-9.
1989: Eva M Sevick-Muraca; Rakesh K Jain
Geometric resistance to blood flow in solid tumors perfused ex vivo: effects of tumor size and perfusion pressure.
Cancer research 1989;49(13):3506-12.
1989: Rakesh K Jain
Delivery of novel therapeutic agents in tumors: physiological barriers and strategies.
Journal of the National Cancer Institute 1989;81(8):570-6.
1989: Laurence T Baxter; Rakesh K Jain
Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection.
Microvascular research 1989;37(1):77-104.
1988: Rakesh K Jain; Laurence T Baxter
Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure.
Cancer research 1988;48(24 Pt 1):7022-32.
1988: Laurence T Baxter; Rakesh K Jain
Vascular permeability and interstitial diffusion in superfused tissues: a two-dimensional model.
Microvascular research 1988;36(1):108-15.
1988: Rakesh K Jain
Determinants of tumor blood flow: a review.
Cancer research 1988;48(10):2641-58.
1988: Eva M Sevick-Muraca; Rakesh K Jain
Blood flow and venous pH of tissue-isolated Walker 256 carcinoma during hyperglycemia.
Cancer research 1988;48(5):1201-7.
1987: Laurence T Baxter; Rakesh K Jain; Erik Svensjö
Vascular permeability and interstitial diffusion of macromolecules in the hamster cheek pouch: effects of vasoactive drugs.
Microvascular research 1987;34(3):336-48.
1987: Rakesh K Jain
Transport of molecules across tumor vasculature.
Cancer metastasis reviews 1987;6(4):559-93.

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