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Karl Jakobs

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Frank vom Dorp; Harald Sanders; Christof Boergermann; Gerd Lümmen; Herbert Rübben; Karl H Jakobs; Martina Schmidt
Inhibition of Rho-kinase abrogates migration of human transitional cell carcinoma cells: results of an in vitro study.
Carsten Sand; Maria Grandoch; Christof Börgermann; Paschal A Oude Weernink; Yvonne Mahlke; Benjamin Schwindenhammer; Artur-Aron Weber; Jens W Fischer; Karl H Jakobs; Martina Schmidt
8-pCPT-conjugated cyclic AMP analogs exert thromboxane receptor antagonistic properties.
Michael ter Braak; Kerstin Danneberg; Karin Lichte; Kerstin Liphardt; Nicholas T Ktistakis; Stuart M Pitson; Timothy Hla; Karl H Jakobs; Dagmar Meyer Zu Heringdorf
Galpha(q)-mediated plasma membrane translocation of sphingosine kinase-1 and cross-activation of S1P receptors.

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2011: Frank vom Dorp; Harald Sanders; Christof Boergermann; Gerd Lümmen; Herbert Rübben; Karl H Jakobs; Martina Schmidt
Inhibition of Rho-kinase abrogates migration of human transitional cell carcinoma cells: results of an in vitro study.
Urologia internationalis 2011;86(2):220-7.
2010: Carsten Sand; Maria Grandoch; Christof Börgermann; Paschal A Oude Weernink; Yvonne Mahlke; Benjamin Schwindenhammer; Artur-Aron Weber; Jens W Fischer; Karl H Jakobs; Martina Schmidt
8-pCPT-conjugated cyclic AMP analogs exert thromboxane receptor antagonistic properties.
Thrombosis and haemostasis 2010;103(3):662-78.
2009: Michael ter Braak; Kerstin Danneberg; Karin Lichte; Kerstin Liphardt; Nicholas T Ktistakis; Stuart M Pitson; Timothy Hla; Karl H Jakobs; Dagmar Meyer Zu Heringdorf
Galpha(q)-mediated plasma membrane translocation of sphingosine kinase-1 and cross-activation of S1P receptors.
Biochimica et biophysica acta 2009;1791(5):357-70.
2009: Maria Grandoch; Maider López de Jesús; Paschal A Oude Weernink; Artur-Aron Weber; Karl H Jakobs; Martina Schmidt
B cell receptor-induced growth arrest and apoptosis in WEHI-231 immature B lymphoma cells involve cyclic AMP and Epac proteins.
Cellular signalling 2009;21(4):609-21.
2008: Karin Lichte; Roberto Rossi; Kerstin Danneberg; Michael ter Braak; Ulrich Kürschner; Karl H Jakobs; Burkhard Kleuser; Dagmar Meyer Zu Heringdorf
Lysophospholipid receptor-mediated calcium signaling in human keratinocytes.
The Journal of investigative dermatology 2008;128(6):1487-98.
2007: Li Han; Matthias B Stope; Maider López de Jesús; Paschal A Oude Weernink; Martina Urban; Thomas Wieland; Dieter Rosskopf; Kensaku Mizuno; Karl H Jakobs; Martina Schmidt
Direct stimulation of receptor-controlled phospholipase D1 by phospho-cofilin.
The EMBO journal 2007;26(19):4189-202.
2007: Andreas Vogt; Susanne Lutz; Ulrich Rümenapp; Li Han; Karl H Jakobs; Martina Schmidt; Thomas Wieland
Regulator of G-protein signalling 3 redirects prototypical Gi-coupled receptors from Rac1 to RhoA activation.
Cellular signalling 2007;19(6):1229-37.
2007: Martina Schmidt; Carsten Sand; Karl H Jakobs; Martin C Michel; Paschal A Oude Weernink
Epac and the cardiovascular system.
Current opinion in pharmacology 2007;7(2):193-200.
2007: Dagmar Meyer Zu Heringdorf; Karl H Jakobs
Lysophospholipid receptors: signalling, pharmacology and regulation by lysophospholipid metabolism.
Biochimica et biophysica acta 2007;1768(4):923-40.
2007: Paschal A Oude Weernink; Li Han; Karl H Jakobs; Martina Schmidt
Dynamic phospholipid signaling by G protein-coupled receptors.
Biochimica et biophysica acta 2007;1768(4):888-900.
2007: Dagmar Meyer Zu Heringdorf; Karl H Jakobs
Renal mesangial cells: moving on sphingosine kinase-1.
British journal of pharmacology 2007;150(3):255-7.
2006: Maider López de Jesús; Matthias B Stope; Paschal A Oude Weernink; Yvonne Mahlke; Christof Börgermann; Viktoria N Ananaba; Christian Rimmbach; Dieter Rosskopf; Martin C Michel; Karl H Jakobs; Martina Schmidt
Cyclic AMP-dependent and Epac-mediated activation of R-Ras by G protein-coupled receptors leads to phospholipase D stimulation.
The Journal of biological chemistry 2006;281(31):21837-47.
2006: Regina Alemany; Oliver Vögler; Silvia Terés; Carolina Egea; Carmela Baamonde; Francisca Barceló; Carlos Delgado; Karl H Jakobs; Pablo V Escribá
Antihypertensive action of 2-hydroxyoleic acid in SHRs via modulation of the protein kinase A pathway and Rho kinase.
Journal of lipid research 2006;47(8):1762-70.
2005: Susanne Lutz; Andrea Freichel-Blomquist; Yang Yang; Ulrich Rümenapp; Karl H Jakobs; Martina Schmidt; Thomas Wieland
The guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA.
The Journal of biological chemistry 2005;280(12):11134-9.
2004: Melanie Keiper; Matthias B Stope; Daniel Szatkowski; Anja Böhm; Karina Tysack; Frank vom Dorp; Oliver Saur; Paschal A Oude Weernink; Sandrine Evellin; Karl H Jakobs; Martina Schmidt
Epac- and Ca2+ -controlled activation of Ras and extracellular signal-regulated kinases by Gs-coupled receptors.
The Journal of biological chemistry 2004;279(45):46497-508.
2004: Paschal A Oude Weernink; Martina Schmidt; Karl H Jakobs
Regulation and cellular roles of phosphoinositide 5-kinases.
European journal of pharmacology 2004;500(1-3):87-99.
2004: Chris J van Koppen; Karl H Jakobs
Arrestin-independent internalization of G protein-coupled receptors.
Molecular pharmacology 2004;66(3):365-7.
2004: Frank vom Dorp; Aysegül Y Sari; Harald Sanders; Melanie Keiper; Paschal A Oude Weernink; Karl H Jakobs; Martina Schmidt
Inhibition of phospholipase C-epsilon by Gi-coupled receptors.
Cellular signalling 2004;16(8):921-8.
2004: Matthias B Stope; Frank vom Dorp; Daniel Szatkowski; Anja Böhm; Melanie Keiper; Jan Nolte; Paschal A Oude Weernink; Dieter Rosskopf; Sandrine Evellin; Karl H Jakobs; Martina Schmidt
Rap2B-dependent stimulation of phospholipase C-epsilon by epidermal growth factor receptor mediated by c-Src phosphorylation of RasGRP3.
Molecular and cellular biology 2004;24(11):4664-76.
2004: Susanne Lutz; Andrea Freichel-Blomquist; Ulrich Rümenapp; Martina Schmidt; Karl H Jakobs; Thomas Wieland
p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene.
Naunyn-Schmiedeberg's archives of pharmacology 2004;369(5):540-6.
2004: Paschal A Oude Weernink; Konstantinos Meletiadis; Silvia Hommeltenberg; Matthias Hinz; Hisamitsu Ishihara; Martina Schmidt; Karl H Jakobs
Activation of type I phosphatidylinositol 4-phosphate 5-kinase isoforms by the Rho GTPases, RhoA, Rac1, and Cdc42.
The Journal of biological chemistry 2004;279(9):7840-9.
2004: Dieter Rosskopf; Karl H Jakobs
More hints on Wnts: gene profiling by beta2-adrenergic receptor-frizzled chimeras.
Molecular pharmacology 2004;65(1):12-4.
2003: Dagmar Meyer Zu Heringdorf; Karoly Liliom; Michael Schaefer; Kerstin Danneberg; Jonathan H Jaggar; Gabor Tigyi; Karl H Jakobs
Photolysis of intracellular caged sphingosine-1-phosphate causes Ca2+ mobilization independently of G-protein-coupled receptors.
FEBS letters 2003;554(3):443-9.
2003: Dagmar Meyer zu Heringdorf; Myriam E M Vincent; Matthias Lipinski; Kerstin Danneberg; Udo Stropp; Dong-An Wang; Gabor Tigyi; Karl H Jakobs
Inhibition of Ca(2+) signalling by the sphingosine 1-phosphate receptor S1P(1).
Cellular signalling 2003;15(7):677-87.
2003: Dieter Rosskopf; Karin Koch; Christiane Habich; Jörg Geerdes; Axel Ludwig; Sabine Wilhelms; Karl H Jakobs; Winfried Siffert
Interaction of Gbeta3s, a splice variant of the G-protein Gbeta3, with Ggamma- and Galpha-proteins.
Cellular signalling 2003;15(5):479-88.
2003: Friederike Cuello; Rudiger A Schulze; Frank Heemeyer; Helmut E Meyer; Susanne Lutz; Karl H Jakobs; Feraydoon Niroomand; Thomas Wieland
Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta.
The Journal of biological chemistry 2003;278(9):7220-6.
2003: Hans-Joerg Hippe; Susanne Lutz; Friederike Cuello; Katrin Knorr; Achim Vogt; Karl H Jakobs; Thomas Wieland; Feraydoon Niroomand
Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Specific activation of Gsalpha by an NDPK B.Gbetagamma complex in H10 cells.
The Journal of biological chemistry 2003;278(9):7227-33.
2003: Christoph Altmann; Dagmar Meyer Zu Heringdorf; Dilek Böyükbas; Michael Haude; Karl H Jakobs; Martin C Michel
Sphingosylphosphorylcholine, a naturally occurring lipid mediator, inhibits human platelet function.
British journal of pharmacology 2003;138(3):435-44.
2002: Carola Heneweer; Lars Hendric Kruse; Felix Kindhäuser; Martina Schmidt; Karl H Jakobs; Hans-Werner Denker; Michael Thie
Adhesiveness of human uterine epithelial RL95-2 cells to trophoblast: rho protein regulation.
Molecular human reproduction 2002;8(11):1014-22.
2002: Ulrich Rümenapp; Andrea Freichel-Blomquist; Burkhard Wittinghofer; Karl H Jakobs; Thomas Wieland
A mammalian Rho-specific guanine-nucleotide exchange factor (p164-RhoGEF) without a pleckstrin homology domain.
The Biochemical journal 2002;366(Pt 3):721-8.
2002: Dagmar Meyer Zu Heringdorf; Herbert M Himmel; Karl H Jakobs
Sphingosylphosphorylcholine-biological functions and mechanisms of action.
Biochimica et biophysica acta 2002;1582(1-3):178-89.
2002: Sandrine Evellin; Jan Nolte; Karina Tysack; Frank vom Dorp; Markus Thiel; Paschal A Oude Weernink; Karl H Jakobs; Edwin J Webb; Jon W Lomasney; Martina Schmidt
Stimulation of phospholipase C-epsilon by the M3 muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B.
The Journal of biological chemistry 2002;277(19):16805-13.
2002: Mercedeh Fahimi-Vahid; Nils Gosau; Christina Michalek; Li Han; Karl H Jakobs; Martina Schmidt; Neil Roberts; Metin Avkiran; Thomas Wieland
Distinct signaling pathways mediate cardiomyocyte phospholipase D stimulation by endothelin-1 and thrombin.
Journal of molecular and cellular cardiology 2002;34(4):441-53.
2002: Martin C Michel; Angela Bischoff; Karl H Jakobs
Comparison of problem-and lecture-based pharmacology teaching.
Trends in pharmacological sciences 2002;23(4):168-70.
2002: Susanne Lutz; Doris Baltus; Karl H Jakobs; Feraydoon Niroomand
Spontaneous release of GDP from Gi proteins and inhibition of adenylyl cyclase in cardiac sarcolemmal membranes.
Naunyn-Schmiedeberg's archives of pharmacology 2002;365(1):50-5.
2002: Peter Czyborra; Miriam Saxe; Charlotte Fetscher; Dagmar Meyer Zu Heringdorf; Stefan Herzig; Karl H Jakobs; Martin C Michel; Angela Bischoff
Transient relaxation of rat mesenteric microvessels by ceramides.
British journal of pharmacology 2002;135(2):417-26.
2001: Regina Alemany; Burkhard Kleuser; Lars Ruwisch; Kerstin Danneberg; Holger Lass; R Hashemi; S Spiegel; Karl H Jakobs; Dagmar Meyer Zu Heringdorf
Depolarisation induces rapid and transient formation of intracellular sphingosine-1-phosphate.
FEBS letters 2001;509(2):239-44.
2001: Martina Schmidt; Sandrine Evellin; Paschal A Oude Weernink; F von Dorp; H Rehmann; J W Lomasney; Karl H Jakobs
A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase.
Nature cell biology 2001;3(11):1020-4.
2001: Chris J van Koppen; Dagmar Meyer Zu Heringdorf; Regina Alemany; Karl H Jakobs
Sphingosine kinase-mediated calcium signaling by muscarinic acetylcholine receptors.
Life sciences 2001;68(22-23):2535-40.
2001: Angela Bischoff; Dagmar Meyer Zu Heringdorf; Karl H Jakobs; Martin C Michel
Lysosphingolipid receptor-mediated diuresis and natriuresis in anaesthetized rats.
British journal of pharmacology 2001;132(8):1925-33.
2001: Dagmar Meyer Zu Heringdorf; Holger Lass; I Kuchar; M Lipinski; Regina Alemany; Ulrich Rümenapp; Karl H Jakobs
Stimulation of intracellular sphingosine-1-phosphate production by G-protein-coupled sphingosine-1-phosphate receptors.
European journal of pharmacology 2001;414(2-3):145-54.
2001: Ulrich Rümenapp; M Asmus; H Schablowski; M Woznicki; Li Han; Karl H Jakobs; Mercedeh Fahimi-Vahid; Christina Michalek; Thomas Wieland; Martina Schmidt
The M3 muscarinic acetylcholine receptor expressed in HEK-293 cells signals to phospholipase D via G12 but not Gq-type G proteins: regulators of G proteins as tools to dissect pertussis toxin-resistant G proteins in receptor-effector coupling.
The Journal of biological chemistry 2001;276(4):2474-9.
2000: A Blomquist; G Schwörer; H Schablowski; A Psoma; Michaela Lehnen; Karl H Jakobs; Ulrich Rümenapp
Identification and characterization of a novel Rho-specific guanine nucleotide exchange factor.
The Biochemical journal 2000;352 Pt 2():319-25.
2000: Martina Schmidt; Markus Frings; M L Mono; Y Guo; Paschal A Oude Weernink; Sandrine Evellin; Li Han; Karl H Jakobs
G protein-coupled receptor-induced sensitization of phospholipase C stimulation by receptor tyrosine kinases.
The Journal of biological chemistry 2000;275(42):32603-10.
2000: Regina Alemany; B Sichelschmidt; D M zu Heringdorf; Holger Lass; Chris J van Koppen; Karl H Jakobs
Stimulation of sphingosine-1-phosphate formation by the P2Y(2) receptor in HL-60 cells: Ca(2+) requirement and implication in receptor-mediated Ca(2+) mobilization, but not MAP kinase activation.
Molecular pharmacology 2000;58(3):491-7.
2000: Angela Bischoff; Peter Czyborra; Dagmar Meyer Zu Heringdorf; Karl H Jakobs; Martin C Michel
Sphingosine-1-phosphate reduces rat renal and mesenteric blood flow in vivo in a pertussis toxin-sensitive manner.
British journal of pharmacology 2000;130(8):1878-83.
2000: Angela Bischoff; Peter Czyborra; Charlotte Fetscher; Dagmar Meyer Zu Heringdorf; Karl H Jakobs; Martin C Michel
Sphingosine-1-phosphate and sphingosylphosphorylcholine constrict renal and mesenteric microvessels in vitro.
British journal of pharmacology 2000;130(8):1871-7.
2000: Paschal A Oude Weernink; Y Guo; C Zhang; Martina Schmidt; Christoph von Eichel-Streiber; Karl H Jakobs
Control of cellular phosphatidylinositol 4,5-bisphosphate levels by adhesion signals and rho GTPases in NIH 3T3 fibroblasts involvement of both phosphatidylinositol-4-phosphate 5-kinase and phospholipase C.
European journal of biochemistry / FEBS 2000;267(16):5237-46.
2000: Herbert M Himmel; Dagmar Meyer Zu Heringdorf; Eva M Graf; Dobromir Dobrev; Ariane Kortner; Stephan Schüler; Karl H Jakobs; Ursula Ravens
Evidence for Edg-3 receptor-mediated activation of I(K.ACh) by sphingosine-1-phosphate in human atrial cardiomyocytes.
Molecular pharmacology 2000;58(2):449-54.
2000: Y Werbonat; N Kleutges; Karl H Jakobs; Chris J van Koppen
Essential role of dynamin in internalization of M2 muscarinic acetylcholine and angiotensin AT1A receptors.
The Journal of biological chemistry 2000;275(29):21969-74.
2000: Paschal A Oude Weernink; P Schulte; Y Guo; J Wetzel; M Amano; K Kaibuchi; S Haverland; M Voss; Martina Schmidt; G W Mayr; Karl H Jakobs
Stimulation of phosphatidylinositol-4-phosphate 5-kinase by Rho-kinase.
The Journal of biological chemistry 2000;275(14):10168-74.
2000: R Krudewig; B Langer; Oliver Vögler; N Markschies; M Erl; Karl H Jakobs; Chris J van Koppen
Distinct internalization of M2 muscarinic acetylcholine receptors confers selective and long-lasting desensitization of signaling to phospholipase C.
Journal of neurochemistry 2000;74(4):1721-30.
2000: Ulrich Rümenapp; Gerd Lümmen; Sebastian Virchow; J Hanske; Dagmar Meyer Zu Heringdorf; Karl H Jakobs
Sphingolipid receptor signaling and function in human bladder carcinoma cells: inhibition of LPA- but enhancement of thrombin-stimulated cell motility.
Naunyn-Schmiedeberg's archives of pharmacology 2000;361(1):1-11.
1999: M Voss; Paschal A Oude Weernink; S Haupenthal; U Möller; Robbert Cool; B Bauer; Jacques Camonis; Karl H Jakobs; Martina Schmidt
Phospholipase D stimulation by receptor tyrosine kinases mediated by protein kinase C and a Ras/Ral signaling cascade.
The Journal of biological chemistry 1999;274(49):34691-8.
1999: Dagmar Meyer Zu Heringdorf; Holger Lass; I Kuchar; Regina Alemany; Y Guo; Martina Schmidt; Karl H Jakobs
Role of sphingosine kinase in Ca(2+) signalling by epidermal growth factor receptor.
FEBS letters 1999;461(3):217-22.
1999: Ulrich Rümenapp; A Blomquist; G Schwörer; H Schablowski; A Psoma; Karl H Jakobs
Rho-specific binding and guanine nucleotide exchange catalysis by KIAA0380, a dbl family member.
FEBS letters 1999;459(3):313-8.
1999: Martina Schmidt; M Voss; Paschal A Oude Weernink; J Wetzel; M Amano; K Kaibuchi; Karl H Jakobs
A role for rho-kinase in rho-controlled phospholipase D stimulation by the m3 muscarinic acetylcholine receptor.
The Journal of biological chemistry 1999;274(21):14648-54.
1999: Oliver Vögler; B Nolte; M Voss; Martina Schmidt; Karl H Jakobs; Chris J van Koppen
Regulation of muscarinic acetylcholine receptor sequestration and function by beta-arrestin.
The Journal of biological chemistry 1999;274(18):12333-8.
1999: Annette Schürmann; M Schmidt; M Asmus; S Bayer; Frank Fliegert; S Koling; S Massmann; C Schilf; M C Subauste; M Voss; Karl H Jakobs; Hans-Georg Joost
The ADP-ribosylation factor (ARF)-related GTPase ARF-related protein binds to the ARF-specific guanine nucleotide exchange factor cytohesin and inhibits the ARF-dependent activation of phospholipase D.
The Journal of biological chemistry 1999;274(14):9744-51.
1999: Regina Alemany; Dagmar Meyer Zu Heringdorf; Chris J van Koppen; Karl H Jakobs
Formyl peptide receptor signaling in HL-60 cells through sphingosine kinase.
The Journal of biological chemistry 1999;274(7):3994-9.
1999: Oliver Vögler; P Krummenerl; Martina Schmidt; Karl H Jakobs; Chris J van Koppen
RhoA-sensitive trafficking of muscarinic acetylcholine receptors.
The Journal of pharmacology and experimental therapeutics 1999;288(1):36-42.
1998: Ulrich Rümenapp; Martina Schmidt; S Olesch; S Ott; C V Eichel-Streiber; Karl H Jakobs
Tyrosine-phosphorylation-dependent and rho-protein-mediated control of cellular phosphatidylinositol 4,5-bisphosphate levels.
The Biochemical journal 1998;334 ( Pt 3)():625-31.
1998: Dagmar Meyer Zu Heringdorf; N Niederdräing; E Neumann; R Fröde; Holger Lass; Chris J van Koppen; Karl H Jakobs
Discrimination between plasma membrane and intracellular target sites of sphingosylphosphorylcholine.
European journal of pharmacology 1998;354(1):113-22.
1998: Martina Schmidt; B Lohmann; K Hammer; S Haupenthal; M V Nehls; Karl H Jakobs
Gi- and protein kinase C-mediated heterologous potentiation of phospholipase C signaling by G protein-coupled receptors.
Molecular pharmacology 1998;53(6):1139-48.
1998: Dagmar Meyer Zu Heringdorf; Holger Lass; Regina Alemany; K T Laser; E Neumann; C Zhang; Martina Schmidt; U Rauen; Karl H Jakobs; Chris J van Koppen
Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptors.
The EMBO journal 1998;17(10):2830-7.
1998: Oliver Vögler; G S Bogatkewitsch; C Wriske; P Krummenerl; Karl H Jakobs; Chris J van Koppen
Receptor subtype-specific regulation of muscarinic acetylcholine receptor sequestration by dynamin. Distinct sequestration of m2 receptors.
The Journal of biological chemistry 1998;273(20):12155-60.
1998: Herbert M Himmel; Dagmar Meyer Zu Heringdorf; B Windorfer; Chris J van Koppen; Ursula Ravens; Karl H Jakobs
Guanine nucleotide-sensitive inhibition of L-type Ca2+ current by lysosphingolipids in RINm5F insulinoma cells.
Molecular pharmacology 1998;53(5):862-9.
1998: Martina Schmidt; M Voss; M Thiel; B Bauer; Andreas Grannass; E Tapp; Robbert Cool; J de Gunzburg; Christoph von Eichel-Streiber; Karl H Jakobs
Specific inhibition of phorbol ester-stimulated phospholipase D by Clostridium sordellii lethal toxin and Clostridium difficile toxin B-1470 in HEK-293 cells. Restoration by Ral GTPases.
The Journal of biological chemistry 1998;273(13):7413-22.
1998: Winfried Siffert; Dieter Rosskopf; G Siffert; S Busch; A Moritz; R Erbel; Arya Sharma; E Ritz; H E Wichmann; Karl H Jakobs; Bernhard Horsthemke
Association of a human G-protein beta3 subunit variant with hypertension.
Nature genetics 1998;18(1):45-8.
1997: Gerd Lümmen; Sebastian Virchow; Ulrich Rümenapp; Martina Schmidt; Thomas Wieland; Thomas Otto; Herbert Rübben; Karl H Jakobs
Identification of G protein-coupled receptors potently stimulating migration of human transitional-cell carcinoma cells.
Naunyn-Schmiedeberg's archives of pharmacology 1997;356(6):769-76.
1997: Ulrich Rümenapp; Martina Schmidt; F Wahn; E Tapp; Andreas Grannass; Karl H Jakobs
Characteristics of protein-kinase-C- and ADP-ribosylation-factor-stimulated phospholipase D activities in human embryonic kidney cells.
European journal of biochemistry / FEBS 1997;248(2):407-14.
1997: Dagmar Meyer Zu Heringdorf; Chris J van Koppen; Karl H Jakobs
Molecular diversity of sphingolipid signalling.
FEBS letters 1997;410(1):34-8.
1997: Feraydoon Niroomand; Roman A Mura; Karl H Jakobs; B Rauch; Wolfgang Kübler
Receptor-independent activation of cardiac adenylyl cyclase by GDP and membrane-associated nucleoside diphosphate kinase. A new cardiotonic mechanism?
Journal of molecular and cellular cardiology 1997;29(5):1479-86.
1997: J Keller; Martina Schmidt; B Hussein; Ulrich Rümenapp; Karl H Jakobs
Muscarinic receptor-stimulated cytosol-membrane translocation of RhoA.
FEBS letters 1997;403(3):299-302.
1997: Martina Schmidt; Ulrich Rümenapp; J Keller; B Lohmann; Karl H Jakobs
Regulation of phospholipase C and D activities by small molecular weight G proteins and muscarinic receptors.
Life sciences 1997;60(13-14):1093-100.
1996: Frank Pietruck; A Moritz; M Montemurro; A Sell; S Busch; Dieter Rosskopf; Sebastian Virchow; H Esche; N Brockmeyer; Karl H Jakobs; Winfried Siffert
Selectively enhanced cellular signaling by Gi proteins in essential hypertension. G alpha i2, G alpha i3, G beta 1, and G beta 2 are not mutated.
Circulation research 1996;79(5):974-83.
1996: D Meyer zu Heringdrof; Chris J van Koppen; B Windorfer; Herbert M Himmel; Karl H Jakobs
Calcium signalling by G protein-coupled sphingolipid receptors in bovine aortic endothelial cells.
Naunyn-Schmiedeberg's archives of pharmacology 1996;354(4):397-403.
1996: Martina Schmidt; C Nehls; Ulrich Rümenapp; Karl H Jakobs
m3 Muscarinic receptor-induced and Gi-mediated heterologous potentiation of phospholipase C stimulation: role of phosphoinositide synthesis.
Molecular pharmacology 1996;50(4):1038-46.
1996: C Zhang; Martina Schmidt; C von Eichei-Streiber; Karl H Jakobs
Inhibition by toxin B of inositol phosphate formation induced by G protein-coupled and tyrosine kinase receptors in N1E-115 neuroblastoma cells: involvement of Rho proteins.
Molecular pharmacology 1996;50(4):864-9.
1996: Martina Schmidt; Ulrich Rümenapp; C Nehls; S Ott; J Keller; Christoph von Eichel-Streiber; Karl H Jakobs
Restoration of Clostridium difficile toxin-B-inhibited phospholipase D by phosphatidylinositol 4,5-bisphosphate.
European journal of biochemistry / FEBS 1996;240(3):707-12.
1996: Thomas Wieland; Dagmar Meyer Zu Heringdorf; R A Schulze; S Kaldenberg-Stasch; Karl H Jakobs
Receptor-induced translocation of activated guanine-nucleotide-binding protein alpha i subunits to the cytoskeleton in myeloid differentiated human leukemia (HL-60) cells.
European journal of biochemistry / FEBS 1996;239(3):752-8.
1996: G S Bogatkewitsch; W Lenz; Karl H Jakobs; Chris J van Koppen
Receptor internalization delays m4 muscarinic acetylcholine receptor resensitization at the plasma membrane.
Molecular pharmacology 1996;50(2):424-9.
1996: S Vogt; Oliver Vögler; C Zhang; U Weller; Karl H Jakobs; Chris J van Koppen
Muscarinic acetylcholine receptor trafficking in streptolysin O-permeabilized MDCK cells.
Naunyn-Schmiedeberg's archives of pharmacology 1996;354(2):128-35.
1996: Martina Schmidt; C Bienek; Ulrich Rümenapp; C Zhang; G Lümmen; Karl H Jakobs; I Just; K Aktories; M Moos; Christoph von Eichel-Streiber
A role for Rho in receptor- and G protein-stimulated phospholipase C. Reduction in phosphatidylinositol 4,5-bisphosphate by Clostridium difficile toxin B.
Naunyn-Schmiedeberg's archives of pharmacology 1996;354(2):87-94.
1996: Chris J van Koppen; Dagmar Meyer Zu Heringdorf; C Zhang; K T Laser; Karl H Jakobs
A distinct G(i) protein-coupled receptor for sphingosylphosphorylcholine in human leukemia HL-60 cells and human neutrophils.
Molecular pharmacology 1996;49(6):956-61.
1996: H M Ockenfels; Stephan N Wagner; P Oeljeklaus; B Schneck; G Nussbaum; Karl H Jakobs; M Goos
Inhibition of T cell cAMP formation by cyclosporin A and FK506.
Naunyn-Schmiedeberg's archives of pharmacology 1996;353(5):513-6.
1996: Martina Schmidt; Ulrich Rümenapp; C Bienek; J Keller; Christoph von Eichel-Streiber; Karl H Jakobs
Inhibition of receptor signaling to phospholipase D by Clostridium difficile toxin B. Role of Rho proteins.
The Journal of biological chemistry 1996;271(5):2422-6.
1996: Dagmar Meyer Zu Heringdorf; K Liedel; S Kaldenberg-Stasch; Martin C Michel; Karl H Jakobs; Thomas Wieland
Translocation of microfilament-associated inhibitory guanine-nucleotide-binding proteins to the plasma membrane in myeloid differentiated human leukemia (HL-60) cells.
European journal of biochemistry / FEBS 1996;235(3):670-6.
1996: Chris J van Koppen; M Meyer zu Heringdorf; K T Laser; C Zhang; Karl H Jakobs; M Bünemann; Lutz Pott
Activation of a high affinity Gi protein-coupled plasma membrane receptor by sphingosine-1-phosphate.
The Journal of biological chemistry 1996;271(4):2082-7.
1996: Ulrich Rümenapp; Martina Schmidt; Miklós Geiszt; Karl H Jakobs
Participation of small GTP-binding proteins in m3 muscarinic acetylcholine receptor signalling to phospholipase D and C.
Progress in brain research 1996;109():209-16.
1995: M Bünemann; Bodo Brandts; D M zu Heringdorf; Chris J van Koppen; Karl H Jakobs; Lutz Pott
Activation of muscarinic K+ current in guinea-pig atrial myocytes by sphingosine-1-phosphate.
The Journal of physiology 1995;489 ( Pt 3)():701-7.
1995: Chris J van Koppen; W Lenz; J P Nunes; C Zhang; Martina Schmidt; Karl H Jakobs
The role of membrane proximal threonine residues conserved among guanine-nucleotide-binding-protein-coupled receptors in internalization of the m4 muscarinic acetylcholine receptor.
European journal of biochemistry / FEBS 1995;234(2):536-41.
1995: Ulrich Rümenapp; Miklós Geiszt; F Wahn; Martina Schmidt; Karl H Jakobs
Evidence for ADP-ribosylation-factor-mediated activation of phospholipase D by m3 muscarinic acetylcholine receptor.
European journal of biochemistry / FEBS 1995;234(1):240-4.
1995: Martina Schmidt; C Bienek; Chris J van Koppen; Martin C Michel; Karl H Jakobs
Differential calcium signalling by m2 and m3 muscarinic acetylcholine receptors in a single cell type.
Naunyn-Schmiedeberg's archives of pharmacology 1995;352(5):469-76.
1995: Martina Schmidt; B Fasselt; Ulrich Rümenapp; C Bienek; Thomas Wieland; Chris J van Koppen; Karl H Jakobs
Rapid and persistent desensitization of m3 muscarinic acetylcholine receptor-stimulated phospholipase D. Concomitant sensitization of phospholipase C.
The Journal of biological chemistry 1995;270(34):19949-56.
1995: Ulrich Loos; S Hagner; U R Bohr; G S Bogatkewitsch; Karl H Jakobs; Chris J van Koppen
Enhanced cAMP accumulation by the human thyrotropin receptor variant with the Pro52Thr substitution in the extracellular domain.
European journal of biochemistry / FEBS 1995;232(1):62-5.
1995: Winfried Siffert; Dieter Rosskopf; A Moritz; Thomas Wieland; S Kaldenberg-Stasch; N Kettler; K Hartung; S Beckmann; Karl H Jakobs
Enhanced G protein activation in immortalized lymphoblasts from patients with essential hypertension.
The Journal of clinical investigation 1995;96(2):759-66.
1995: S Busch; Thomas Wieland; H Esche; Karl H Jakobs; Winfried Siffert
G protein regulation of the Na+/H+ antiporter in Xenopus laevis oocytes. Involvement of protein kinases A and C.
The Journal of biological chemistry 1995;270(30):17898-901.
1995: Thomas Wieland; K Liedel; S Kaldenberg-Stasch; Dagmar Meyer Zu Heringdorf; Martina Schmidt; Karl H Jakobs
Analysis of receptor-G protein interactions in permeabilized cells.
Naunyn-Schmiedeberg's archives of pharmacology 1995;351(4):329-36.
1994: W Lenz; C Petrusch; Karl H Jakobs; Chris J van Koppen
Agonist-induced down-regulation of the m4 muscarinic acetylcholine receptor occurs without changes in receptor mRNA steady-state levels.
Naunyn-Schmiedeberg's archives of pharmacology 1994;350(5):507-13.
1994: Martina Schmidt; S M Hüwe; B Fasselt; D Homann; Ulrich Rümenapp; J Sandmann; Karl H Jakobs
Mechanisms of phospholipase D stimulation by m3 muscarinic acetylcholine receptors. Evidence for involvement of tyrosine phosphorylation.
European journal of biochemistry / FEBS 1994;225(2):667-75.
1994: K Götze; Karl H Jakobs
Unoccupied beta-adrenoceptor-induced adenylyl cyclase stimulation in turkey erythrocyte membranes.
European journal of pharmacology 1994;268(2):151-8.
1994: C Wieland; Karl H Jakobs; Thomas Wieland
Altered guanine nucleoside triphosphate binding to transducin by cholera toxin-catalysed ADP-ribosylation.
Cellular signalling 1994;6(5):487-92.
1994: Chris J van Koppen; A Sell; W Lenz; Karl H Jakobs
Deletion analysis of the m4 muscarinic acetylcholine receptor. Molecular determinants for activation of but not coupling to the Gi guanine-nucleotide-binding regulatory protein regulate receptor internalization.
European journal of biochemistry / FEBS 1994;222(2):525-31.
1994: S Kaldenberg-Stasch; M Baden; B Fesseler; Karl H Jakobs; Thomas Wieland
Receptor-stimulated guanine-nucleotide-triphosphate binding to guanine-nucleotide-binding regulatory proteins. Nucleotide exchange and beta-subunit-mediated phosphotransfer reactions.
European journal of biochemistry / FEBS 1994;221(1):25-33.
1994: T Weiland; Karl H Jakobs
Measurement of receptor-stimulated guanosine 5'-O-(gamma-thio)triphosphate binding by G proteins.
Methods in enzymology 1994;237():3-13.
1993: T Mewes; S Dutz; Ursula Ravens; Karl H Jakobs
Activation of calcium currents in cardiac myocytes by empty beta-adrenoceptors.
Circulation 1993;88(6):2916-22.
1993: Thomas Wieland; B Nürnberg; I Ulibarri; S Kaldenberg-Stasch; G Schultz; Karl H Jakobs
Guanine nucleotide-specific phosphate transfer by guanine nucleotide-binding regulatory protein beta-subunits. Characterization of the phosphorylated amino acid.
The Journal of biological chemistry 1993;268(24):18111-8.
1993: C Kupprion; Thomas Wieland; Karl H Jakobs
Receptor-stimulated dissociation of GTP[S] from Gi-proteins in membranes of HL-60 cells.
Cellular signalling 1993;5(4):425-33.
1992: G Hilf; Karl H Jakobs
Activation of solubilized G-proteins by muscarinic acetylcholine receptors.
Cellular signalling 1992;4(6):787-94.
1992: Thomas Wieland; P Gierschik; Karl H Jakobs
G protein-mediated receptor-receptor interaction: studies with chemotactic receptors in membranes of human leukemia (HL 60) cells.
Naunyn-Schmiedeberg's archives of pharmacology 1992;346(5):475-81.
1992: Thomas Wieland; Karl H Jakobs
Evidence for nucleoside diphosphokinase-dependent channeling of guanosine 5'-(gamma-thio)triphosphate to guanine nucleotide-binding proteins.
Molecular pharmacology 1992;42(5):731-5.
1992: Thomas Wieland; M Ronzani; Karl H Jakobs
Stimulation and inhibition of human platelet adenylylcyclase by thiophosphorylated transducin beta gamma-subunits.
The Journal of biological chemistry 1992;267(29):20791-7.
1992: Christian Gachet; Pierre Savi; Philippe Ohlmann; Jean-Pierre Maffrand; Karl H Jakobs; Jean-Pierre Cazenave
ADP receptor induced activation of guanine nucleotide binding proteins in rat platelet membranes--an effect selectively blocked by the thienopyridine clopidogrel.
Thrombosis and haemostasis 1992;68(1):79-83.
1992: Christian Gachet; Jean-Pierre Cazenave; Philippe Ohlmann; G Hilf; Thomas Wieland; Karl H Jakobs
ADP receptor-induced activation of guanine-nucleotide-binding proteins in human platelet membranes.
European journal of biochemistry / FEBS 1992;207(1):259-63.
1992: M Camps; C Hou; D Sidiropoulos; J B Stock; Karl H Jakobs; P Gierschik
Stimulation of phospholipase C by guanine-nucleotide-binding protein beta gamma subunits.
European journal of biochemistry / FEBS 1992;206(3):821-31.
1992: P Schultz; P Stannek; M Voigt; Karl H Jakobs; P Gierschik
Complementation of formyl peptide receptor-mediated signal transduction in Xenopus laevis oocytes.
The Biochemical journal 1992;284 ( Pt 1)():207-12.
1992: G Hilf; Karl H Jakobs
Agonist-independent inhibition of G protein activation by muscarinic acetylcholine receptor antagonists in cardiac membranes.
European journal of pharmacology 1992;225(3):245-52.
1992: R W Kupper; B Dewald; Karl H Jakobs; M Baggiolini; P Gierschik
G-protein activation by interleukin 8 and related cytokines in human neutrophil plasma membranes.
The Biochemical journal 1992;282 ( Pt 2)():429-34.
1992: G Hilf; C Kupprion; Thomas Wieland; Karl H Jakobs
Dissociation of guanosine 5'-[gamma-thio]triphosphate from guanine-nucleotide-binding regulatory proteins in native cardiac membranes. Regulation by nucleotides and muscarinic acetylcholine receptors.
European journal of biochemistry / FEBS 1992;204(2):725-31.
1991: Thomas Wieland; J Bremerich; P Gierschik; Karl H Jakobs
Contribution of nucleoside diphosphokinase to guanine nucleotide regulation of agonist binding to formyl peptide receptors.
European journal of pharmacology 1991;208(1):17-23.
1991: P Gierschik; R Moghtader; C Straub; K Dieterich; Karl H Jakobs
Signal amplification in HL-60 granulocytes. Evidence that the chemotactic peptide receptor catalytically activates guanine-nucleotide-binding regulatory proteins in native plasma membranes.
European journal of biochemistry / FEBS 1991;197(3):725-32.
1991: Thomas Wieland; I Ulibarri; P Gierschik; Karl H Jakobs
Activation of signal-transducing guanine-nucleotide-binding regulatory proteins by guanosine 5'-[gamma-thio]triphosphate. Information transfer by intermediately thiophosphorylated beta gamma subunits.
European journal of biochemistry / FEBS 1991;196(3):707-16.
1991: C Reithmann; P Gierschik; K Werdan; Karl H Jakobs
Tumor necrosis factor alpha up-regulates Gi alpha and G beta proteins and adenylyl cyclase responsiveness in rat cardiomyocytes.
European journal of pharmacology 1991;206(1):53-60.
1990: Thomas Wieland; I Ulibarri; P Gierschik; Alan Hall; K Aktories; Karl H Jakobs
Interaction of recombinant rho A GTP-binding proteins with photoexcited rhodopsin.
FEBS letters 1990;274(1-2):111-4.
1990: M Camps; C F Hou; Karl H Jakobs; P Gierschik
Guanosine 5'-[gamma-thio]triphosphate-stimulated hydrolysis of phosphatidylinositol 4,5-bisphosphate in HL-60 granulocytes. Evidence that the guanine nucleotide acts by relieving phospholipase C from an inhibitory constraint.
The Biochemical journal 1990;271(3):743-8.
1990: C Reithmann; P Gierschik; U Müller; K Werdan; Karl H Jakobs
Pseudomonas exotoxin A prevents beta-adrenoceptor-induced upregulation of Gi protein alpha-subunits and adenylyl cyclase desensitization in rat heart muscle cells.
Molecular pharmacology 1990;37(5):631-8.
1990: Thomas Wieland; I Ulibarri; K Aktories; P Gierschik; Karl H Jakobs
Interaction of small G proteins with photoexcited rhodopsin.
FEBS letters 1990;263(2):195-8.
1990: C Reithmann; P Gierschik; K Werdan; Karl H Jakobs
Hormonal regulation of Gi alpha level and adenylyl cyclase responsiveness.
British journal of clinical pharmacology 1990;30 Suppl 1():118S-120S.
1989: P Gierschik; D Sidiropoulos; Karl H Jakobs
Two distinct Gi-proteins mediate formyl peptide receptor signal transduction in human leukemia (HL-60) cells.
The Journal of biological chemistry 1989;264(36):21470-3.
1989: G Hilf; P Gierschik; Karl H Jakobs
Muscarinic acetylcholine receptor-stimulated binding of guanosine 5'-O-(3-thiotriphosphate) to guanine-nucleotide-binding proteins in cardiac membranes.
European journal of biochemistry / FEBS 1989;186(3):725-31.
1989: P Gierschik; D Sidiropoulos; M Steisslinger; Karl H Jakobs
Na+ regulation of formyl peptide receptor-mediated signal transduction in HL 60 cells. Evidence that the cation prevents activation of the G-protein by unoccupied receptors.
European journal of pharmacology 1989;172(6):481-92.
1989: C Reithmann; P Gierschik; D Sidiropoulos; K Werdan; Karl H Jakobs
Mechanism of noradrenaline-induced heterologous desensitization of adenylate cyclase stimulation in rat heart muscle cells: increase in the level of inhibitory G-protein alpha-subunits.
European journal of pharmacology 1989;172(3):211-21.
1989: P Gierschik; M Steisslinger; D Sidiropoulos; E Herrmann; Karl H Jakobs
Dual Mg2+ control of formyl-peptide-receptor--G-protein interaction in HL 60 cells. Evidence that the low-agonist-affinity receptor interacts with and activates the G-protein.
European journal of biochemistry / FEBS 1989;183(1):97-105.
1989: Karl H Jakobs; Thomas Wieland
Evidence for receptor-regulated phosphotransfer reactions involved in activation of the adenylate cyclase inhibitory G protein in human platelet membranes.
European journal of biochemistry / FEBS 1989;183(1):115-21.
1989: G Hilf; Karl H Jakobs
Activation of cardiac G-proteins by muscarinic acetylcholine receptors: regulation by Mg2+ and Na+ ions.
European journal of pharmacology 1989;172(2):155-63.
1989: Thomas Wieland; Karl H Jakobs
Receptor-regulated formation of GTP[gamma S] with subsequent persistent Gs-protein activation in membranes of human platelets.
FEBS letters 1989;245(1-2):189-93.
1988: C Greiner; Karl H Jakobs
Guanine nucleotide-independent inhibition of adenylate cyclase by a stimulatory hormone.
The Biochemical journal 1988;254(1):27-31.
1988: E Herrmann; Karl H Jakobs
Stimulation and inhibition of human platelet membrane high-affinity GTPase by neomycin.
FEBS letters 1988;229(1):49-53.
1988: Karl H Jakobs; R Grandt
Thrombin-like inhibitory action of trypsin and trypsin-like proteases on human platelet adenylate cyclase.
European journal of biochemistry / FEBS 1988;172(1):255-60.
1988: Karl H Jakobs; K Aktories
Stimulation of high-affinity GTPase by trypsin and trypsin-like proteinases in membranes of human platelets.
The Biochemical journal 1988;249(3):639-43.
1987: P Gierschik; Karl H Jakobs
Receptor-mediated ADP-ribosylation of a phospholipase C-stimulating G protein.
FEBS letters 1987;224(1):219-23.