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Bent Jakobsen

Research Profile

Chemicals & Drugs

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Emmet McCormack; Olivier Morteau; Maja Mujić; Tereza Osdal; Alex S Powlesland; malkit sami; Deborah H Sutton; Annelise Vuidepot; Katherine J Adams; Milos Aleksic; Rebecca Ashfield; Deborah Baker; Bjørn Tore Gjertsen; Namir J Hassan; Carl H June; Michael Kalos; Akhil Kotian; Nikolai M Lissin; Bent K Jakobsen
Bi-specific TCR-anti CD3 redirected T-cell targeting of NY-ESO-1- and LAGE-1-positive tumors.
Milos Aleksic; Kyong-Mi Chang; Nathaniel Liddy; Peter E Molloy; Nicholas Pumphrey; Annelise Vuidepot; Bent K Jakobsen
Different affinity windows for virus and cancer-specific T-cell receptors: implications for therapeutic strategies.
Gabriela Plesa; Alan D Bennett; Bruce R Blazar; Jessie Gavarret; Bent K Jakobsen; Nathaniel Liddy; Andrew Medvec; Camila Robles-Oteiza; Annelise Vuidepot; Caleph B Wilson; Yangbing Zhao; Lingjie Zheng; James L Riley
TCR affinity and specificity requirements for human regulatory T-cell function.

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2013: Emmet McCormack; Olivier Morteau; Maja Mujić; Tereza Osdal; Alex S Powlesland; malkit sami; Deborah H Sutton; Annelise Vuidepot; Katherine J Adams; Milos Aleksic; Rebecca Ashfield; Deborah Baker; Bjørn Tore Gjertsen; Namir J Hassan; Carl H June; Michael Kalos; Akhil Kotian; Nikolai M Lissin; Bent K Jakobsen
Bi-specific TCR-anti CD3 redirected T-cell targeting of NY-ESO-1- and LAGE-1-positive tumors.
Cancer immunology, immunotherapy : CII 2013;62(4):773-85.
2012: Milos Aleksic; Kyong-Mi Chang; Nathaniel Liddy; Peter E Molloy; Nicholas Pumphrey; Annelise Vuidepot; Bent K Jakobsen
Different affinity windows for virus and cancer-specific T-cell receptors: implications for therapeutic strategies.
European journal of immunology 2012;42(12):3174-9.
2012: Gabriela Plesa; Alan D Bennett; Bruce R Blazar; Jessie Gavarret; Bent K Jakobsen; Nathaniel Liddy; Andrew Medvec; Camila Robles-Oteiza; Annelise Vuidepot; Caleph B Wilson; Yangbing Zhao; Lingjie Zheng; James L Riley
TCR affinity and specificity requirements for human regulatory T-cell function.
Blood 2012;119(15):3420-30.
2012: Anna M Bulek; david cole; Garry Dolton; Jan W Drijfhout; Anna Fuller; Emma Gostick; Stephanie Gras; Guo C Huang; Bent K Jakobsen; Robin R Knight; Nikolai M Lissin; Florian Madura; John J Miles; Peter E Molloy; Mark Peakman; David A Price; Pierre J Rizkallah; Jamie Rossjohn; Ania Skowera; Linda Wooldridge; Andrew K Sewell
Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes.
Nature immunology 2012;13(3):283-9.
2010: Ruth K Moysey; Yi Li; Samantha J Paston; Emma E Baston; malkit sami; Brian J Cameron; Jessie Gavarret; Penio Todorov; Annelise Vuidepot; Steven M Dunn; Nicholas J Pumphrey; Katherine J Adams; Fang Yuan; Rebecca E Dennis; Deborah H Sutton; Andy D Johnson; Joanna E Brewer; Rebecca Ashfield; Nikolai M Lissin; Bent K Jakobsen
High affinity soluble ILT2 receptor: a potent inhibitor of CD8(+) T cell activation.
Protein & cell 2010;1(12):1118-27.
2010: Nathaniel Liddy; Peter E Molloy; Alan D Bennett; Jonathan M Boulter; Bent K Jakobsen; Yi Li
Production of a soluble disulfide bond-linked TCR in the cytoplasm of Escherichia coli trxB gor mutants.
Molecular biotechnology 2010;45(2):140-9.
2010: Gediminas Matulis; Joseph Sanderson; Nikolai M Lissin; Maria B Asparuhova; Gopal R Bommineni; Daniel Schümperli; Richard R Schmidt; Peter M Villiger; Bent K Jakobsen; Stephan D Gadola
Innate-like control of human iNKT cell autoreactivity via the hypervariable CDR3beta loop.
PLoS biology 2010;8(6):e1000402.
2009: david cole; Fang Yuan; Pierre J Rizkallah; John J Miles; Emma Gostick; David A Price; George F Gao; Bent K Jakobsen; Andrew K Sewell
Germ line-governed recognition of a cancer epitope by an immunodominant human T-cell receptor.
The Journal of biological chemistry 2009;284(40):27281-9.
2008: Angel Varela-Rohena; Peter E Molloy; Steven M Dunn; Yi Li; Megan M Suhoski; Richard G Carroll; Anita Milicic; Tara Mahon; Deborah H Sutton; Bruno Laugel; Ruth Moysey; Brian J Cameron; Annelise Vuidepot; Marco A Purbhoo; david cole; Rodney E Phillips; Carl H June; Bent K Jakobsen; Andrew K Sewell; James L Riley
Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor.
Nature medicine 2008;14(12):1390-5.
2008: Paul F Robbins; Yong F Li; Mona El-Gamil; Yangbing Zhao; Jennifer A Wargo; Zhili Zheng; Hui Xu; Richard A Morgan; Steven A Feldman; Laura A Johnson; Alan D Bennett; Steven M Dunn; Tara M Mahon; Bent K Jakobsen; STEVEN ROSENBERG
Single and dual amino acid substitutions in TCR CDRs can enhance antigen-specific T cell functions.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(9):6116-31.
2008: david cole; Steven M Dunn; malkit sami; Jonathan M Boulter; Bent K Jakobsen; Andrew K Sewell
T cell receptor engagement of peptide-major histocompatibility complex class I does not modify CD8 binding.
Molecular immunology 2008;45(9):2700-9.
2007: Yangbing Zhao; Alan D Bennett; Zhili Zheng; Qiong J Wang; Paul F Robbins; Lawrence Y L Yu; Yi Li; Peter Molloy; Steven M Dunn; Bent K Jakobsen; STEVEN ROSENBERG; Richard A Morgan
High-affinity TCRs generated by phage display provide CD4+ T cells with the ability to recognize and kill tumor cell lines.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(9):5845-54.
2007: Fang Yuan; Theonie Georgiou; Theresa Hillon; Emma Gostick; David A Price; Andrew K Sewell; Ruth Moysey; Jessie Gavarret; Annelise Vuidepot; malkit sami; John I Bell; George F Gao; Pierre J Rizkallah; Bent K Jakobsen
Crystallization and preliminary X-ray structural studies of a Melan-A pMHC-TCR complex.
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 9):758-60.
2007: Nicholas Pumphrey; Annelise Vuidepot; Bent K Jakobsen; Göran Forsberg; Björn Walse; Karin Lindkvist-Petersson
Cutting edge: Evidence of direct TCR alpha-chain interaction with superantigen.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(5):2700-4.
2007: malkit sami; Pierre J Rizkallah; Steve Dunn; Peter Molloy; Ruth Moysey; Annelise Vuidepot; Emma Baston; Penio T Todorov; Yi Li; Feng Gao; Jonathan M Boulter; Bent K Jakobsen
Crystal structures of high affinity human T-cell receptors bound to peptide major histocompatibility complex reveal native diagonal binding geometry.
Protein engineering, design & selection : PEDS 2007;20(8):397-403.
2007: Marco A Purbhoo; Yi Li; Deborah H Sutton; Joanna E Brewer; Emma Gostick; Giovanna Bossi; Bruno Laugel; Ruth Moysey; Emma Baston; Nathaniel Liddy; Brian Cameron; Alan D Bennett; Rebecca Ashfield; Anita Milicic; David A Price; Brendan J Classon; Andrew K Sewell; Bent K Jakobsen
The HLA A*0201-restricted hTERT(540-548) peptide is not detected on tumor cells by a CTL clone or a high-affinity T-cell receptor.
Molecular cancer therapeutics 2007;6(7):2081-91.
2007: david cole; Nicholas Pumphrey; Jonathan M Boulter; malkit sami; John I Bell; Emma Gostick; David A Price; George F Gao; Andrew K Sewell; Bent K Jakobsen
Human TCR-binding affinity is governed by MHC class restriction.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(9):5727-34.
2007: david cole; Pierre J Rizkallah; Jonathan M Boulter; malkit sami; Annelise Vuidepot; Meir Glick; Feng Gao; John I Bell; Bent K Jakobsen; George F Gao
Computational design and crystal structure of an enhanced affinity mutant human CD8 alphaalpha coreceptor.
Proteins 2007;67(1):65-74.
2006: Rebecca Ashfield; Bent K Jakobsen
Making high-affinity T-cell receptors: a new class of targeted therapeutics.
IDrugs : the investigational drugs journal 2006;9(8):554-9.
2006: Marco A Purbhoo; Deborah H Sutton; Joanna E Brewer; Rebecca E Mullings; Maxine E Hill; Tara Mahon; Julia Karbach; Elke Jäger; Brian Cameron; Nikolai M Lissin; Paresh Vyas; Ji-Li Chen; Vincenzo Cerundolo; Bent K Jakobsen
Quantifying and imaging NY-ESO-1/LAGE-1-derived epitopes on tumor cells using high affinity T cell receptors.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(12):7308-16.
2006: Steven M Dunn; Pierre J Rizkallah; Emma Baston; Tara Mahon; Brian Cameron; Ruth Moysey; Feng Gao; malkit sami; Jonathan M Boulter; Yi Li; Bent K Jakobsen
Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity.
Protein science : a publication of the Protein Society 2006;15(4):710-21.
2006: Stephan D Gadola; Michael Koch; Jon Marles-Wright; Nikolai M Lissin; Dawn Shepherd; Gediminas Matulis; Karl Harlos; Peter M Villiger; David I Stuart; Bent K Jakobsen; Vincenzo Cerundolo; E Yvonne Jones
Structure and binding kinetics of three different human CD1d-alpha-galactosylceramide-specific T cell receptors.
The Journal of experimental medicine 2006;203(3):699-710.
2006: david cole; Pierre J Rizkallah; Feng Gao; Neil I Watson; Jonathan M Boulter; John I Bell; malkit sami; George F Gao; Bent K Jakobsen
Crystal structure of HLA-A*2402 complexed with a telomerase peptide.
European journal of immunology 2006;36(1):170-9.
2005: Jonathan M Boulter; Bent K Jakobsen
Stable, soluble, high-affinity, engineered T cell receptors: novel antibody-like proteins for specific targeting of peptide antigens.
Clinical and experimental immunology 2005;142(3):454-60.
2005: Peter Molloy; Andrew K Sewell; Bent K Jakobsen
Soluble T cell receptors: novel immunotherapies.
Current opinion in pharmacology 2005;5(4):438-43.
2005: Ji-Li Chen; Guillaume Stewart-Jones; Giovanna Bossi; Nikolai M Lissin; Linda Wooldridge; Ed Man-Lik Choi; Gerhard Held; P Rod Dunbar; Robert M Esnouf; malkit sami; Jonathan M Boulter; Pierre J Rizkallah; Christoph Renner; Andrew Sewell; Philip van der Merwe; Bent K Jakobsen; Gillian Griffiths; E Yvonne Jones; Vincenzo Cerundolo
Structural and kinetic basis for heightened immunogenicity of T cell vaccines.
The Journal of experimental medicine 2005;201(8):1243-55.
2005: david cole; Pierre J Rizkallah; malkit sami; Nikolai M Lissin; Feng Gao; John I Bell; Jonathan M Boulter; Meir Glick; Annelise Vuidepot; Bent K Jakobsen; George F Gao
Crystallization and preliminary X-ray structural studies of a high-affinity CD8alphaalpha co-receptor to pMHC.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 3):285-7.
2005: Yi Li; Ruth Moysey; Peter Molloy; Annelise Vuidepot; Tara Mahon; Emma Baston; Steven Dunn; Nathaniel Liddy; Jansen Jacob; Bent K Jakobsen; Jonathan M Boulter
Directed evolution of human T-cell receptors with picomolar affinities by phage display.
Nature biotechnology 2005;23(3):349-54.
2005: Bruno Laugel; Jonathan M Boulter; Nikolai M Lissin; Annelise Vuidepot; Yi Li; Emma Gostick; Laura E Crotty; Daniel C Douek; Joris Hemelaar; David A Price; Bent K Jakobsen; Andrew K Sewell
Design of soluble recombinant T cell receptors for antigen targeting and T cell inhibition.
The Journal of biological chemistry 2005;280(3):1882-92.
2003: Ed Man-Lik Choi; Ji-Li Chen; Linda Wooldridge; Mariolina Salio; Anna Lissina; Nikolai M Lissin; Ian F Hermans; Jonathan Silk; Mirza Fareed; Michael J Palmowski; P Rod Dunbar; Bent K Jakobsen; Andrew K Sewell; Vincenzo Cerundolo
High avidity antigen-specific CTL identified by CD8-independent tetramer staining.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(10):5116-23.
2003: Jonathan M Boulter; Meir Glick; Penio T Todorov; Emma Baston; malkit sami; Pierre J Rizkallah; Bent K Jakobsen
Stable, soluble T-cell receptor molecules for crystallization and therapeutics.
Protein engineering 2003;16(9):707-11.
2003: Sarah L Hutchinson; Linda Wooldridge; Sabrina Tafuro; Bruno Laugel; Meir Glick; Jonathan M Boulter; Bent K Jakobsen; David A Price; Andrew K Sewell
The CD8 T cell coreceptor exhibits disproportionate biological activity at extremely low binding affinities.
The Journal of biological chemistry 2003;278(27):24285-93.
2002: Annette Oxenius; Bent K Jakobsen; Philippa J Easterbrook; Jonathan M Boulter; Tin Tun; Anele Waters; Juliet Agudelo; M C N M Barnardo; Rodney E Phillips; David A Price
Complete mapping of a novel HLA A*6801-restricted HIV-1 Tat epitope directly with a rapid modified enzyme-linked immunospot assay.
AIDS (London, England) 2002;16(9):1285-7.
2002: Meir Glick; David A Price; Annelise Vuidepot; Torben B Andersen; Sarah L Hutchinson; Bruno Laugel; Andrew K Sewell; Jonathan M Boulter; P Rod Dunbar; Vincenzo Cerundolo; Annette Oxenius; John I Bell; W Graham Richards; Bent K Jakobsen
Novel CD8+ T cell antagonists based on beta 2-microglobulin.
The Journal of biological chemistry 2002;277(23):20840-6.
2001: Marco A Purbhoo; Jonathan M Boulter; David A Price; Annelise Vuidepot; Christopher Hourigan; P Rod Dunbar; Kara Olson; Sara J Dawson; Rodney E Phillips; Bent K Jakobsen; John I Bell; Andrew K Sewell
The human CD8 coreceptor effects cytotoxic T cell activation and antigen sensitivity primarily by mediating complete phosphorylation of the T cell receptor zeta chain.
The Journal of biological chemistry 2001;276(35):32786-92.
2000: George F Gao; Benjamin E Willcox; Jessica R Wyer; Jonathan M Boulter; Christopher A O'Callaghan; Katsumi Maenaka; David I Stuart; E Yvonne Jones; Philip van der Merwe; John I Bell; Bent K Jakobsen
Classical and nonclassical class I major histocompatibility complex molecules exhibit subtle conformational differences that affect binding to CD8alphaalpha.
The Journal of biological chemistry 2000;275(20):15232-8.
1999: Benjamin E Willcox; George F Gao; Jessica R Wyer; Christopher A O'Callaghan; Jonathan M Boulter; E Yvonne Jones; Philip van der Merwe; John I Bell; Bent K Jakobsen
Production of soluble alphabeta T-cell receptor heterodimers suitable for biophysical analysis of ligand binding.
Protein science : a publication of the Protein Society 1999;8(11):2418-23.
1999: Andrew K Sewell; UC Gerth; David A Price; Marco A Purbhoo; Jonathan M Boulter; George F Gao; John I Bell; Rodney E Phillips; Bent K Jakobsen
Antagonism of cytotoxic T-lymphocyte activation by soluble CD8.
Nature medicine 1999;5(4):399-404.
1999: Benjamin E Willcox; George F Gao; Jessica R Wyer; J E Ladbury; John I Bell; Bent K Jakobsen; Philip van der Merwe
TCR binding to peptide-MHC stabilizes a flexible recognition interface.
Immunity 1999;10(3):357-65.
1999: Jessica R Wyer; Benjamin E Willcox; George F Gao; UC Gerth; Simon J Davis; John I Bell; Philip van der Merwe; Bent K Jakobsen
T cell receptor and coreceptor CD8 alphaalpha bind peptide-MHC independently and with distinct kinetics.
Immunity 1999;10(2):219-25.
1999: Christopher A O'Callaghan; M F Byford; Jessica R Wyer; Benjamin E Willcox; Bent K Jakobsen; Andrew J McMichael; John I Bell
BirA enzyme: production and application in the study of membrane receptor-ligand interactions by site-specific biotinylation.
Analytical biochemistry 1999;266(1):9-15.
1998: Christopher A O'Callaghan; Jose Tormo; Benjamin E Willcox; C D Blundell; Bent K Jakobsen; David I Stuart; A J McMichael; John I Bell; E Yvonne Jones
Production, crystallization, and preliminary X-ray analysis of the human MHC class Ib molecule HLA-E.
Protein science : a publication of the Protein Society 1998;7(5):1264-6.
1998: George F Gao; UC Gerth; Jessica R Wyer; Benjamin E Willcox; Christopher A O'Callaghan; Z Zhang; E Yvonne Jones; John I Bell; Bent K Jakobsen
Assembly and crystallization of the complex between the human T cell coreceptor CD8alpha homodimer and HLA-A2.
Protein science : a publication of the Protein Society 1998;7(5):1245-9.
1998: Marco A Purbhoo; Andrew K Sewell; Paul Klenerman; P J Goulder; K L Hilyard; John I Bell; Bent K Jakobsen; Rodney E Phillips
Copresentation of natural HIV-1 agonist and antagonist ligands fails to induce the T cell receptor signaling cascade.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(8):4527-32.
1998: Christopher A O'Callaghan; Jose Tormo; Benjamin E Willcox; Veronique M Braud; Bent K Jakobsen; David I Stuart; Andrew J McMichael; John I Bell; E Yvonne Jones
Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E.
Molecular cell 1998;1(4):531-41.
1997: George F Gao; Jose Tormo; UC Gerth; Jessica R Wyer; Andrew J McMichael; David I Stuart; John I Bell; E Yvonne Jones; Bent K Jakobsen
Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2.
Nature 1997;387(6633):630-4.
1997: S J Vessey; D H Barouch; S N McAdam; L G Tussey; M A Davenport; Christopher A O'Callaghan; John I Bell; Andrew J McMichael; Bent K Jakobsen
Engagement of a T cell receptor by major histocompatibility complex irrespective of peptide.
European journal of immunology 1997;27(4):879-85.
1996: S W Reid; S McAdam; K J Smith; Paul Klenerman; Christopher A O'Callaghan; Karl Harlos; Bent K Jakobsen; Andrew J McMichael; John I Bell; David I Stuart; E Yvonne Jones
Antagonist HIV-1 Gag peptides induce structural changes in HLA B8.
The Journal of experimental medicine 1996;184(6):2279-86.
1996: S J Vessey; John I Bell; Bent K Jakobsen
A functionally significant allelic polymorphism in a T cell receptor V beta gene segment.
European journal of immunology 1996;26(7):1660-3.
1996: S W Reid; K J Smith; Bent K Jakobsen; Christopher A O'Callaghan; H Reyburn; Karl Harlos; David I Stuart; Andrew J McMichael; John I Bell; E Yvonne Jones
Production and crystallization of MHC class I B allele single peptide complexes.
FEBS letters 1996;383(1-2):119-23.