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Hieronim Jakubowski

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Maxim Chudaev; Emanuel Goldman; Mohit Raja Jain; Hieronim Jakubowski; Hong Li; Kiran Poruri; Sanjay Tyagi; Wei Chen; Wlodek Mandecki
Design and properties of efficient tRNA:EF-Tu FRET system for studies of ribosomal translation.
Yulia Y Stroylova; Jean-Marc Chobert; Hieronim Jakubowski; Vladimir I Muronetz; Thomas Haertlé
N-homocysteinylation of ovine prion protein induces amyloid-like transformation.
Joanna Perla-Kajan; Hieronim Jakubowski
Paraoxonase 1 and homocysteine metabolism.

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2013: Maxim Chudaev; Emanuel Goldman; Mohit Raja Jain; Hieronim Jakubowski; Hong Li; Kiran Poruri; Sanjay Tyagi; Wei Chen; Wlodek Mandecki
Design and properties of efficient tRNA:EF-Tu FRET system for studies of ribosomal translation.
Protein engineering, design & selection : PEDS 2013;26(5):347-57.
2012: Yulia Y Stroylova; Jean-Marc Chobert; Hieronim Jakubowski; Vladimir I Muronetz; Thomas Haertlé
N-homocysteinylation of ovine prion protein induces amyloid-like transformation.
Archives of biochemistry and biophysics 2012;526(1):29-37.
2012: Joanna Perla-Kajan; Hieronim Jakubowski
Paraoxonase 1 and homocysteine metabolism.
Amino acids 2012;43(4):1405-17.
2012: Kamila Borowczyk; Joanna Tisończyk; Hieronim Jakubowski
Metabolism and neurotoxicity of homocysteine thiolactone in mice: protective role of bleomycin hydrolase.
Amino acids 2012;43(3):1339-48.
2012: Paweł Bogdanski; Anna Jablecka; Piotr P Jagodzinski; Mariusz Lacinski; Ewa Miller-Kasprzak; Danuta Pupek-Musialik; Hieronim Jakubowski
Plasma total homocysteine is a determinant of carotid intima-media thickness and circulating endothelial progenitor cells in patients with newly diagnosed hypertension.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2012;50(6):1107-13.
2012: Hieronim Jakubowski
Quality control in tRNA charging.
Wiley interdisciplinary reviews. RNA 2012;3(3):295-310.
2012: Kamila Borowczyk; Diana M Shih; Hieronim Jakubowski
Metabolism and neurotoxicity of homocysteine thiolactone in mice: evidence for a protective role of paraoxonase 1.
Journal of Alzheimer's disease : JAD 2012;30(2):225-31.
2011: Joanna Perla-Kajan; Sebastian Mielcarek; Agnieszka Gryszczyńska; Hieronim Jakubowski
Cation exchange HPLC analysis of desmosines in elastin hydrolysates.
Analytical and bioanalytical chemistry 2011;401(8):2473-9.
2011: Yulia Y Stroylova; Reza Yousefi; Jaroslaw Zimny; Jean-Marc Chobert; Hieronim Jakubowski; Vladimir I Muronetz; Thomas Haertlé
Aggregation and structural changes of α(S1)-, β- and κ-caseins induced by homocysteinylation.
Biochimica et biophysica acta 2011;1814(10):1234-45.
2011: Lukasz Marczak; Marta Sikora; Maciej Stobiecki; Hieronim Jakubowski
Analysis of site-specific N-homocysteinylation of human serum albumin in vitro and in vivo using MALDI-ToF and LC-MS/MS mass spectrometry.
Journal of proteomics 2011;74(7):967-74.
2011: Rafał Głowacki; Edward Bald; Hieronim Jakubowski
An on-column derivatization method for the determination of homocysteine-thiolactone and protein N-linked homocysteine.
Amino acids 2011;41(1):187-94.
2011: Michał Zaąbczyk; Rafał Głowacki; Andrzej Machnik; Paweł Heród; Grzegorz Kazek; Hieronim Jakubowski; Anetta Undas
Elevated concentrations of Nɛ-homocysteinyl-lysine isopeptide in acute myocardial infarction: links with ADMA formation.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2011;49(4):729-35.
2011: Hieronim Jakubowski; Rafał Głowacki
Chemical biology of homocysteine thiolactone and related metabolites.
Advances in clinical chemistry 2011;55():81-103.
2011: Hieronim Jakubowski
Quality control in tRNA charging -- editing of homocysteine.
Acta biochimica Polonica 2011;58(2):149-63.
2010: Rafał Głowacki; Edward Bald; Hieronim Jakubowski
Identification and origin of Nε-homocysteinyl-lysine isopeptide in humans and mice.
Amino acids 2010;39(5):1563-9.
2010: Marta Sikora; Lukasz Marczak; Tomasz Twardowski; Maciej Stobiecki; Hieronim Jakubowski
Direct monitoring of albumin lysine-525 N-homocysteinylation in human serum by liquid chromatography/mass spectrometry.
Analytical biochemistry 2010;405(1):132-4.
2010: Rafał Głowacki; Kamila Borowczyk; Edward Bald; Hieronim Jakubowski
On-column derivatization with o-phthaldialdehyde for fast determination of homocysteine in human urine.
Analytical and bioanalytical chemistry 2010;396(6):2363-6.
2010: Joanna Perla-Kajan; Xin Lin; Barry S Cooperman; Emanuel Goldman; Hieronim Jakubowski; Charlotte R Knudsen; Wlodek Mandecki
Properties of Escherichia coli EF-Tu mutants designed for fluorescence resonance energy transfer from tRNA molecules.
Protein engineering, design & selection : PEDS 2010;23(3):129-36.
2010: Joanna Perla-Kajan; Hieronim Jakubowski
Paraoxonase 1 protects against protein N-homocysteinylation in humans.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(3):931-6.
2010: Jerzy Beltowski; Grazyna Wójcicka; Hieronim Jakubowski
Modulation of paraoxonase 1 and protein N-homocysteinylation by leptin and the synthetic liver X receptor agonist T0901317 in the rat.
The Journal of endocrinology 2010;204(2):191-8.
2010: Joanna Suszynska; Joanna Tisonczyk; Hyoung-gon Lee; Mark A. Smith; Hieronim Jakubowski
Reduced homocysteine-thiolactonase activity in Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2010;19(4):1177-83.
2010: Hieronim Jakubowski
The role of paraoxonase 1 in the detoxification of homocysteine thiolactone.
Advances in experimental medicine and biology 2010;660():113-27.
2009: Marta Sikora; Hieronim Jakubowski
Homocysteine editing and growth inhibition in Escherichia coli.
Microbiology (Reading, England) 2009;155(Pt 6):1858-65.
2009: Hieronim Jakubowski; Joanna Perla-Kajan; Richard H Finnell; Robert M Cabrera; Hong Wang; Sapna Gupta; warren kruger; Jan P Kraus; Diana M Shih
Genetic or nutritional disorders in homocysteine or folate metabolism increase protein N-homocysteinylation in mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(6):1721-7.
2009: Ann Van Campenhout; Corey S Moran; Adam Parr; Paula Clancy; Catherine Rush; Hieronim Jakubowski; Jonathan Golledge
Role of homocysteine in aortic calcification and osteogenic cell differentiation.
Atherosclerosis 2009;202(2):557-66.
2008: Hieronim Jakubowski
The pathophysiological hypothesis of homocysteine thiolactone-mediated vascular disease.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2008;59 Suppl 9():155-67.
2008: Hieronim Jakubowski; Godfried H J Boers; Kevin A Strauss
Mutations in cystathionine beta-synthase or methylenetetrahydrofolate reductase gene increase N-homocysteinylated protein levels in humans.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(12):4071-6.
2008: Hieronim Jakubowski
New method for the determination of protein N-linked homocysteine.
Analytical biochemistry 2008;380(2):257-61.
2008: Joanna Perla-Kajan; Olaf Stanger; Michał Luczak; Agnieszka Ziółkowska; Ludwik K Malendowicz; Tomasz Twardowski; Sárka Lhotak; Richard C Austin; Hieronim Jakubowski
Immunohistochemical detection of N-homocysteinylated proteins in humans and mice.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2008;62(7):473-9.
2007: Hieronim Jakubowski
Facile syntheses of [35S]homocysteine-thiolactone, [35S]homocystine, [35S]homocysteine, and [S-nitroso-35S]homocysteine.
Analytical biochemistry 2007;370(1):124-6.
2007: Xiaohua Jiang; Fan Yang; Eugen Brailoiu; Hieronim Jakubowski; Nae J Dun; Andrew I Schafer; Xiaofeng Yang; William Durante; Hong Wang
Differential regulation of homocysteine transport in vascular endothelial and smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(9):1976-83.
2007: Kevin A Strauss; D Holmes Morton; Erik G Puffenberger; Christine Hendrickson; Donna L Robinson; Conrad Wagner; Sally P Stabler; Robert H Allen; Grazyna Chwatko; Hieronim Jakubowski; Mihai D Niculescu; S Harvey Mudd
Prevention of brain disease from severe 5,10-methylenetetrahydrofolate reductase deficiency.
Molecular genetics and metabolism 2007;91(2):165-75.
2007: Grazyna Chwatko; Godfried H J Boers; Kevin A Strauss; Diana M Shih; Hieronim Jakubowski
Mutations in methylenetetrahydrofolate reductase or cystathionine beta-synthase gene, or a high-methionine diet, increase homocysteine thiolactone levels in humans and mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(8):1707-13.
2007: Joanna Perla-Kajan; Łukasz Marczak; László Kaján; Paweł Skowronek; Tomasz Twardowski; Hieronim Jakubowski
Modification by homocysteine thiolactone affects redox status of cytochrome C.
Biochemistry 2007;46(21):6225-31.
2007: Hieronim Jakubowski
The molecular basis of homocysteine thiolactone-mediated vascular disease.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2007;45(12):1704-16.
2007: Joanna Perla-Kajan; Tomasz Twardowski; Hieronim Jakubowski
Mechanisms of homocysteine toxicity in humans.
Amino acids 2007;32(4):561-72.
2006: Hieronim Jakubowski
Mechanism of the condensation of homocysteine thiolactone with aldehydes.
Chemistry (Weinheim an der Bergstrasse, Germany) 2006;12(31):8039-43.
2006: Anetta Undas; Hieronim Jakubowski
Letter by Undas and Jakubowski regarding article, "Relationship between homocysteine and mortality in chronic kidney disease".
Circulation 2006;114(16):e547; author reply e548.
2006: Anetta Undas; Ewa Stepień; Rafal Glowacki; Joanna Tisończyk; Wieslawa Tracz; Hieronim Jakubowski
Folic acid administration and antibodies against homocysteinylated proteins in subjects with hyperhomocysteinemia.
Thrombosis and haemostasis 2006;96(3):342-7.
2006: Jaroslaw Zimny; Marta Sikora; Andrzej Guranowski; Hieronim Jakubowski
Protective mechanisms against homocysteine toxicity: the role of bleomycin hydrolase.
The Journal of biological chemistry 2006;281(32):22485-92.
2006: Hieronim Jakubowski
Pathophysiological consequences of homocysteine excess.
The Journal of nutrition 2006;136(6 Suppl):1741S-1749S.
2006: Anetta Undas; Jan Brozek; Milosz Jankowski; Zbigniew Siudak; Andrew Szczeklik; Hieronim Jakubowski
Plasma homocysteine affects fibrin clot permeability and resistance to lysis in human subjects.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(6):1397-404.
2006: Rebecca E Taurog; Hieronim Jakubowski; Rowena G Matthews
Synergistic, random sequential binding of substrates in cobalamin-independent methionine synthase.
Biochemistry 2006;45(16):5083-91.
2006: T B Domagała; M Łacinski; Wieslaw Trzeciak; Bharti Mackness; M I Mackness; Hieronim Jakubowski
The correlation of homocysteine-thiolactonase activity of the paraoxonase (PON1) protein with coronary heart disease status.
Cellular and molecular biology (Noisy-le-Grand, France) 2006;52(5):4-10.
2006: Marta Sikora; Tomasz Twardowski; Hieronim Jakubowski
[The role of homocysteine thiolactone in some of human diseases].
Postepy biochemii 2006;52(4):417-23.
2005: Grazyna Chwatko; Hieronim Jakubowski
The determination of homocysteine-thiolactone in human plasma.
Analytical biochemistry 2005;337(2):271-7.
2005: Anetta Undas; Milosz Jankowski; Magdalena Twardowska; Agnieszka Padjas; Hieronim Jakubowski; Andrew Szczeklik
Antibodies to N-homocysteinylated albumin as a marker for early-onset coronary artery disease in men.
Thrombosis and haemostasis 2005;93(2):346-50.
2005: Grazyna Chwatko; Hieronim Jakubowski
Urinary excretion of homocysteine-thiolactone in humans.
Clinical chemistry 2005;51(2):408-15.
2005: Hieronim Jakubowski
Anti-N-homocysteinylated protein autoantibodies and cardiovascular disease.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2005;43(10):1011-4.
2004: Mariusz Lacinski; Wlodzimierz Skorupski; A Cieslinski; J Sokolowska; Wieslaw Trzeciak; Hieronim Jakubowski
Determinants of homocysteine-thiolactonase activity of the paraoxonase-1 (PON1) protein in humans.
Cellular and molecular biology (Noisy-le-Grand, France) 2004;50(8):885-93.
2004: Danila Di Giuseppe; Simona Frosali; Raffaella Priora; Francesca Cherubini Di Simplicio; Giuseppe Buonocore; Carla Cellesi; Pier Leopoldo Capecchi; Franco Laghi Pasini; Pietro Enea Lazzerini; Hieronim Jakubowski; Paolo Di Simplicio
The effects of age and hyperhomocysteinemia on the redox forms of plasma thiols.
The Journal of laboratory and clinical medicine 2004;144(5):235-45.
2004: Joanna Perla-Kajan; Anetta Undas; Tomasz Twardowski; Hieronim Jakubowski
Purification of antibodies against N-homocysteinylated proteins by affinity chromatography on Nomega-homocysteinyl-aminohexyl-Agarose.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;807(2):257-61.
2004: Anetta Undas; Joanna Perla-Kajan; Mariusz Lacinski; Wieslaw Trzeciak; Radosław Kaźmierski; Hieronim Jakubowski
Autoantibodies against N-homocysteinylated proteins in humans: implications for atherosclerosis.
Stroke; a journal of cerebral circulation 2004;35(6):1299-304.
2004: Rafal Glowacki; Hieronim Jakubowski
Cross-talk between Cys34 and lysine residues in human serum albumin revealed by N-homocysteinylation.
The Journal of biological chemistry 2004;279(12):10864-71.
2004: Hieronim Jakubowski
Molecular basis of homocysteine toxicity in humans.
Cellular and molecular life sciences : CMLS 2004;61(4):470-87.
2003: Hieronim Jakubowski
Homocysteine-thiolactone and S-nitroso-homocysteine mediate incorporation of homocysteine into protein in humans.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2003;41(11):1462-6.
2003: Hieronim Jakubowski; Andrzej Guranowski
Metabolism of homocysteine-thiolactone in plants.
The Journal of biological chemistry 2003;278(9):6765-70.
2003: Hieronim Jakubowski
On the health benefits of Allium sp.
Nutrition (Burbank, Los Angeles County, Calif.) 2003;19(2):167-8.
2002: Nicholas J Schork; Jeffrey P Gardner; Li Zhang; Danielle Fallin; Bonnie A Thiel; Hieronim Jakubowski; Abraham Aviv
Genomic association/linkage of sodium lithium countertransport in CEPH pedigrees.
Hypertension 2002;40(5):619-28.
2002: Hieronim Jakubowski
The determination of homocysteine-thiolactone in biological samples.
Analytical biochemistry 2002;308(1):112-9.
2002: Hieronim Jakubowski
Homocysteine is a protein amino acid in humans. Implications for homocysteine-linked disease.
The Journal of biological chemistry 2002;277(34):30425-8.
2001: Hieronim Jakubowski
Translational accuracy of aminoacyl-tRNA synthetases: implications for atherosclerosis.
The Journal of nutrition 2001;131(11):2983S-7S.
2001: Hieronim Jakubowski
Protein N-homocysteinylation: implications for atherosclerosis.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2001;55(8):443-7.
2001: Hieronim Jakubowski; Walter T Ambrosius; J Howard Pratt
Genetic determinants of homocysteine thiolactonase activity in humans: implications for atherosclerosis.
FEBS letters 2001;491(1-2):35-9.
2000: Hieronim Jakubowski
Amino acid selectivity in the aminoacylation of coenzyme A and RNA minihelices by aminoacyl-tRNA synthetases.
The Journal of biological chemistry 2000;275(45):34845-8.
2000: Hieronim Jakubowski
Translational incorporation of S-nitrosohomocysteine into protein.
The Journal of biological chemistry 2000;275(29):21813-6.
2000: Hieronim Jakubowski; L Zhang; Arlene Bardeguez; Abraham Aviv
Homocysteine thiolactone and protein homocysteinylation in human endothelial cells: implications for atherosclerosis.
Circulation research 2000;87(1):45-51.
2000: Hieronim Jakubowski
Calcium-dependent human serum homocysteine thiolactone hydrolase. A protective mechanism against protein N-homocysteinylation.
The Journal of biological chemistry 2000;275(6):3957-62.
2000: Hieronim Jakubowski
Homocysteine thiolactone: metabolic origin and protein homocysteinylation in humans.
The Journal of nutrition 2000;130(2S Suppl):377S-381S.
1999: Hieronim Jakubowski
Protein homocysteinylation: possible mechanism underlying pathological consequences of elevated homocysteine levels.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(15):2277-83.
1999: Hieronim Jakubowski
Misacylation of tRNALys with noncognate amino acids by lysyl-tRNA synthetase.
Biochemistry 1999;38(25):8088-93.
1998: Hieronim Jakubowski
Aminoacylation of coenzyme A and pantetheine by aminoacyl-tRNA synthetases: possible link between noncoded and coded peptide synthesis.
Biochemistry 1998;37(15):5147-53.
1997: Hieronim Jakubowski
Aminoacyl thioester chemistry of class II aminoacyl-tRNA synthetases.
Biochemistry 1997;36(37):11077-85.
1997: Hieronim Jakubowski
Metabolism of homocysteine thiolactone in human cell cultures. Possible mechanism for pathological consequences of elevated homocysteine levels.
The Journal of biological chemistry 1997;272(3):1935-42.
1996: Hieronim Jakubowski
Proofreading in trans by an aminoacyl-tRNA synthetase: a model for single site editing by isoleucyl-tRNA synthetase.
Nucleic acids research 1996;24(13):2505-10.
1996: Hieronim Jakubowski
The synthetic/editing active site of an aminoacyl-tRNA synthetase: evidence for binding of thiols in the editing subsite.
Biochemistry 1996;35(25):8252-9.
1995: Hieronim Jakubowski
Synthesis of cysteine-containing dipeptides by aminoacyl-tRNA synthetases.
Nucleic acids research 1995;23(22):4608-15.
1995: W Gao; Hieronim Jakubowski; Emanuel Goldman
Evidence that uncharged tRNA can inhibit a programmed translational frameshift in Escherichia coli.
Journal of molecular biology 1995;251(2):210-6.
1995: Hieronim Jakubowski
Proofreading in vivo. Editing of homocysteine by aminoacyl-tRNA synthetases in Escherichia coli.
The Journal of biological chemistry 1995;270(30):17672-3.
1994: Hieronim Jakubowski
Energy cost of translational proofreading in vivo. The aminoacylation of transfer RNA in Escherichia coli.
Annals of the New York Academy of Sciences 1994;745():4-20.
1994: W Gao; Emanuel Goldman; Hieronim Jakubowski
Role of carboxy-terminal region in proofreading function of methionyl-tRNA synthetase in Escherichia coli.
Biochemistry 1994;33(38):11528-35.
1994: Hieronim Jakubowski
Editing function of Escherichia coli cysteinyl-tRNA synthetase: cyclization of cysteine to cysteine thiolactone.
Nucleic acids research 1994;22(7):1155-60.
1993: Hieronim Jakubowski; Emanuel Goldman
Methionine-mediated lethality in yeast cells at elevated temperature.
Journal of bacteriology 1993;175(17):5469-76.
1993: Hieronim Jakubowski
Proofreading and the evolution of a methyl donor function. Cyclization of methionine to S-methyl homocysteine thiolactone by Escherichia coli methionyl-tRNA synthetase.
The Journal of biological chemistry 1993;268(9):6549-53.
1993: Hieronim Jakubowski; Emanuel Goldman
Synthesis of homocysteine thiolactone by methionyl-tRNA synthetase in cultured mammalian cells.
FEBS letters 1993;317(3):237-40.
1993: Hieronim Jakubowski
Energy cost of proofreading in vivo: the charging of methionine tRNAs in Escherichia coli.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1993;7(1):168-72.
1992: Hieronim Jakubowski; Emanuel Goldman
Editing of errors in selection of amino acids for protein synthesis.
Microbiological reviews 1992;56(3):412-29.
1991: Hieronim Jakubowski
Proofreading in vivo: editing of homocysteine by methionyl-tRNA synthetase in the yeast Saccharomyces cerevisiae.
The EMBO journal 1991;10(3):593-8.
1990: Emanuel Goldman; Hieronim Jakubowski
Uncharged tRNA, protein synthesis, and the bacterial stringent response.
Molecular microbiology 1990;4(12):2035-40.
1990: Hieronim Jakubowski
Proofreading in vivo: editing of homocysteine by methionyl-tRNA synthetase in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(12):4504-8.
1990: M V Rojiani; Hieronim Jakubowski; Emanuel Goldman
Relationship between protein synthesis and concentrations of charged and uncharged tRNATrp in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(4):1511-5.
1989: M V Rojiani; Hieronim Jakubowski; Emanuel Goldman
Effect of variation of charged and uncharged tRNA(Trp) levels on ppGpp synthesis in Escherichia coli.
Journal of bacteriology 1989;171(12):6493-502.
1988: Hieronim Jakubowski
Negative correlation between the abundance of Escherichia coli aminoacyl-tRNA families and their affinities for elongation factor Tu-GTP.
Journal of theoretical biology 1988;133(3):363-70.