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Ian James

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Yihong Sui; Jennifer H Lee; Michael A DiMicco; Eric J Vanderploeg; Simon M Blake; Han-Hwa Hung; Anna Plaas; Ian E James; Xiao-Yu Song; Michael W Lark; Alan J Grodzinsky
Mechanical injury potentiates proteoglycan catabolism induced by interleukin-6 with soluble interleukin-6 receptor and tumor necrosis factor alpha in immature bovine and adult human articular cartilage.
Sanjay Kumar; LC Dare; Janice Vasko-Moser; Ian E James; Simon M Blake; D J Rickard; Shing-Mei Hwang; Thaddeus Tomaszek; Dennis S Yamashita; Robert W Marquis; H Oh; J U Jeong; Daniel F Veber; Maxine Gowen; Michael W Lark; George B Stroup
A highly potent inhibitor of cathepsin K (relacatib) reduces biomarkers of bone resorption both in vitro and in an acute model of elevated bone turnover in vivo in monkeys.
Kurt D Hankenson; Ian E James; S Apone; George B Stroup; Simon M Blake; X Liang; Michael W Lark; Paul Bornstein
Increased osteoblastogenesis and decreased bone resorption protect against ovariectomy-induced bone loss in thrombospondin-2-null mice.

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All Publications

2009: Yihong Sui; Jennifer H Lee; Michael A DiMicco; Eric J Vanderploeg; Simon M Blake; Han-Hwa Hung; Anna Plaas; Ian E James; Xiao-Yu Song; Michael W Lark; Alan J Grodzinsky
Mechanical injury potentiates proteoglycan catabolism induced by interleukin-6 with soluble interleukin-6 receptor and tumor necrosis factor alpha in immature bovine and adult human articular cartilage.
Arthritis and rheumatism 2009;60(10):2985-96.
2007: Sanjay Kumar; LC Dare; Janice Vasko-Moser; Ian E James; Simon M Blake; D J Rickard; Shing-Mei Hwang; Thaddeus Tomaszek; Dennis S Yamashita; Robert W Marquis; H Oh; J U Jeong; Daniel F Veber; Maxine Gowen; Michael W Lark; George B Stroup
A highly potent inhibitor of cathepsin K (relacatib) reduces biomarkers of bone resorption both in vitro and in an acute model of elevated bone turnover in vivo in monkeys.
Bone 2007;40(1):122-31.
2005: Kurt D Hankenson; Ian E James; S Apone; George B Stroup; Simon M Blake; X Liang; Michael W Lark; Paul Bornstein
Increased osteoblastogenesis and decreased bone resorption protect against ovariectomy-induced bone loss in thrombospondin-2-null mice.
Matrix biology : journal of the International Society for Matrix Biology 2005;24(5):362-70.
2004: Parth Patwari; Veronique Gaschen; Ian E James; E Berger; Simon M Blake; Michael W Lark; Alan J Grodzinsky; Ernst B Hunziker
Ultrastructural quantification of cell death after injurious compression of bovine calf articular cartilage.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2004;12(3):245-52.
2004: Robert W Marquis; Keith W Ward; Theresa J Roethke; Brian R Smith; Yu Ru; Dennis S Yamashita; Thaddeus Tomaszek; Peter D Gorycki; H Y Cheng; Ian E James; George B Stroup; Michael W Lark; Maxine Gowen; Daniel F Veber
An azepanone-based inhibitor of human cathepsin K with improved oral bioavailability in the rat and the monkey.
Molecular pharmaceutics 2004;1(1):97-100.
2003: Parth Patwari; Michael N Cook; Michael A DiMicco; Simon M Blake; Ian E James; Sanjay Kumar; Ada A Cole; Michael W Lark; Alan J Grodzinsky
Proteoglycan degradation after injurious compression of bovine and human articular cartilage in vitro: interaction with exogenous cytokines.
Arthritis and rheumatism 2003;48(5):1292-301.
2003: William H Miller; Peter J Manley; Russell D Cousins; Karl F Erhard; Dirk A Heerding; Chet Kwon; Stephen T Ross; James Samanen; Dennis T Takata; Irene N Uzinskas; Catherine C K Yuan; R Curtis Haltiwanger; Catherine J Gress; Michael W Lark; Shing-Mei Hwang; Ian E James; David J Rieman; Robert N Willette; Tian-Li Yue; Leonard M Azzarano; Kevin L Salyers; Brian R Smith; Keith W Ward; Kyung O Johanson; William F Huffman
Phenylbutyrates as potent, orally bioavailable vitronectin receptor (integrin alphavbeta3) antagonists.
Bioorganic & medicinal chemistry letters 2003;13(8):1483-6.
2002: Michael W Lark; Ian E James
Novel bone antiresorptive approaches.
Current opinion in pharmacology 2002;2(3):330-7.
2002: Michael W Lark; George B Stroup; Ian E James; RA Dodds; Shing-Mei Hwang; Simon M Blake; BA Lechowska; Sandra J Hoffman; Brian R Smith; RD Kapadia; X Liang; Karl F Erhard; Yu Ru; X Dong; Robert W Marquis; Daniel F Veber; Maxine Gowen
A potent small molecule, nonpeptide inhibitor of cathepsin K (SB 331750) prevents bone matrix resorption in the ovariectomized rat.
Bone 2002;30(5):746-53.
2001: George B Stroup; Michael W Lark; Daniel F Veber; A Bhattacharyya; Simon Blake; LC Dare; Karl F Erhard; Sandra J Hoffman; Ian E James; Robert W Marquis; Yu Ru; Janice Vasko-Moser; Brian R Smith; Thaddeus Tomaszek; Maxine Gowen
Potent and selective inhibition of human cathepsin K leads to inhibition of bone resorption in vivo in a nonhuman primate.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2001;16(10):1739-46.
2001: Ian E James; Robert W Marquis; Simon M Blake; Shing-Mei Hwang; Catherine J Gress; Yu Ru; DL Zembryki; Dennis S Yamashita; Michael S McQueney; Thaddeus Tomaszek; HJ Oh; Maxine Gowen; Daniel F Veber; Michael W Lark
Potent and selective cathepsin L inhibitors do not inhibit human osteoclast resorption in vitro.
The Journal of biological chemistry 2001;276(15):11507-11.
2001: RA Dodds; Ian E James; David J Rieman; R Ahern; Shing-Mei Hwang; JR Connor; S D Thompson; Daniel F Veber; FH Drake; S Holmes; Michael W Lark; Maxine Gowen
Human osteoclast cathepsin K is processed intracellularly prior to attachment and bone resorption.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2001;16(3):478-86.
2001: David J Rieman; H A McClung; RA Dodds; Shing-Mei Hwang; M W Holmes; Ian E James; FH Drake; Maxine Gowen
Biosynthesis and processing of cathepsin K in cultured human osteoclasts.
Bone 2001;28(3):282-9.
2001: Michael W Lark; George B Stroup; RA Dodds; RD Kapadia; Sandra J Hoffman; Shing-Mei Hwang; Ian E James; BA Lechowska; X Liang; David J Rieman; Kevin L Salyers; K Ward; Brian R Smith; William H Miller; William F Huffman; Maxine Gowen
Antagonism of the osteoclast vitronectin receptor with an orally active nonpeptide inhibitor prevents cancellous bone loss in the ovariectomized rat.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2001;16(2):319-27.
2000: Ian E James; Sanjay Kumar; M R Barnes; Catherine J Gress; A T Hand; RA Dodds; JR Connor; B R Bradley; D A Campbell; S E Grabill; K Williams; Simon M Blake; Maxine Gowen; Michael W Lark
FrzB-2: a human secreted frizzled-related protein with a potential role in chondrocyte apoptosis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2000;8(6):452-63.
2000: AM Loening; Ian E James; ME Levenston; AM Badger; Eliot H Frank; Bodo Kurz; Mark E Nuttall; Han-Hwa Hung; Simon M Blake; Alan J Grodzinsky; Michael W Lark
Injurious mechanical compression of bovine articular cartilage induces chondrocyte apoptosis.
Archives of biochemistry and biophysics 2000;381(2):205-12.
2000: Maxine Gowen; George B Stroup; RA Dodds; Ian E James; Bartholomew Votta; Brian R Smith; Pradip Bhatnagar; A M Lago; James F Callahan; EG DelMar; MA Miller; Edward F Nemeth; John Fox
Antagonizing the parathyroid calcium receptor stimulates parathyroid hormone secretion and bone formation in osteopenic rats.
The Journal of clinical investigation 2000;105(11):1595-604.
2000: F L Wang; JR Connor; RA Dodds; Ian E James; Sanjay Kumar; C Zou; Michael W Lark; Maxine Gowen; Mark E Nuttall
Differential expression of egr-1 in osteoarthritic compared to normal adult human articular cartilage.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2000;8(3):161-9.
2000: Bartholomew Votta; John White; RA Dodds; Ian E James; JR Connor; EV Lee-Rykaczewski; Christopher Eichman; Sanjay Kumar; Michael W Lark; Maxine Gowen
CKbeta-8 [CCL23], a novel CC chemokine, is chemotactic for human osteoclast precursors and is expressed in bone tissues.
Journal of cellular physiology 2000;183(2):196-207.
1999: Michael W Lark; George B Stroup; Shing-Mei Hwang; Ian E James; David J Rieman; FH Drake; JN Bradbeer; A Mathur; Karl F Erhard; Kenneth A Newlander; Stephen T Ross; Kevin L Salyers; Brian R Smith; William H Miller; William F Huffman; Maxine Gowen
Design and characterization of orally active Arg-Gly-Asp peptidomimetic vitronectin receptor antagonist SB 265123 for prevention of bone loss in osteoporosis.
The Journal of pharmacology and experimental therapeutics 1999;291(2):612-7.
1999: Ian E James; Michael W Lark; DL Zembryki; EV Lee-Rykaczewski; Shing-Mei Hwang; Thaddeus Tomaszek; Pietro Belfiore; Maxine Gowen
Development and characterization of a human in vitro resorption assay: demonstration of utility using novel antiresorptive agents.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1999;14(9):1562-9.
1999: William H Miller; WE Bondinell; Russell D Cousins; Karl F Erhard; Dalia R Jakas; Richard M Keenan; Thomas W Ku; Kenneth A Newlander; Stephen T Ross; R Curtis Haltiwanger; JN Bradbeer; FH Drake; Maxine Gowen; Sandra J Hoffman; Shing-Mei Hwang; Ian E James; Michael W Lark; BA Lechowska; David J Rieman; George B Stroup; Janice Vasko-Moser; DL Zembryki; Leonard M Azzarano; P C Adams; William F Huffman
Orally bioavailable nonpeptide vitronectin receptor antagonists with efficacy in an osteoporosis model.
Bioorganic & medicinal chemistry letters 1999;9(13):1807-12.
1999: Sanjay Kumar; A T Hand; JR Connor; RA Dodds; P J Ryan; J J Trill; S M Fisher; Mark E Nuttall; D B Lipshutz; C Zou; Shing-Mei Hwang; Bartholomew Votta; Ian E James; David J Rieman; Maxine Gowen; John Lee
Identification and cloning of a connective tissue growth factor-like cDNA from human osteoblasts encoding a novel regulator of osteoblast functions.
The Journal of biological chemistry 1999;274(24):17123-31.
1998: U Prabhakar; Ian E James; RA Dodds; EV Lee-Rykaczewski; David J Rieman; D Lipshutz; S Trulli; Zdenka L Jonak; KB Tan; FH Drake; Maxine Gowen
A novel human bone marrow stroma-derived cell line TF274 is highly osteogenic in vitro and in vivo.
Calcified tissue international 1998;63(3):214-20.
1998: JG Emery; P McDonnell; M B Burke; KC Deen; SD Lyn; Carol Silverman; E Dul; Edward R Appelbaum; Christopher Eichman; R DiPrinzio; RA Dodds; Ian E James; M Rosenberg; J C Lee; Peter Young
Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL.
The Journal of biological chemistry 1998;273(23):14363-7.
1997: Bartholomew Votta; MA Levy; AM Badger; JN Bradbeer; RA Dodds; Ian E James; Scott Thompson; MJ Bossard; TJ Carr; JR Connor; Thaddeus Tomaszek; L Szewczuk; FH Drake; Daniel F Veber; Maxine Gowen
Peptide aldehyde inhibitors of cathepsin K inhibit bone resorption both in vitro and in vivo.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1997;12(9):1396-406.
1997: C S Kumar; Ian E James; A Wong; V Mwangi; JA Feild; Parvathi Nuthulaganti; JR Connor; Christopher Eichman; F Ali; Shing-Mei Hwang; David J Rieman; FH Drake; Maxine Gowen
Cloning and characterization of a novel integrin beta3 subunit.
The Journal of biological chemistry 1997;272(26):16390-7.
1996: Ian E James; RA Dodds; E Lee-Rykaczewski; Christopher Eichman; JR Connor; Timothy K Hart; B E Maleeff; R D Lackman; Maxine Gowen
Purification and characterization of fully functional human osteoclast precursors.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1996;11(11):1608-18.
1996: Ian E James; RA Dodds; D L Olivera; Mark E Nuttall; Maxine Gowen
Human osteoclastoma-derived stromal cells: correlation of the ability to form mineralized nodules in vitro with formation of bone in vivo.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1996;11(10):1453-60.
1996: FH Drake; RA Dodds; Ian E James; JR Connor; C Debouck; S Richardson; E Lee-Rykaczewski; L Coleman; David J Rieman; R Barthlow; Gregg Hastings; Maxine Gowen
Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts.
The Journal of biological chemistry 1996;271(21):12511-6.
1995: JR Connor; RA Dodds; Ian E James; Maxine Gowen
Human osteoclast and giant cell differentiation: the apparent switch from nonspecific esterase to tartrate resistant acid phosphatase activity coincides with the in situ expression of osteopontin mRNA.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1995;43(12):1193-201.
1995: RA Dodds; JR Connor; Ian E James; E L Rykaczewski; Edward R Appelbaum; E Dul; Maxine Gowen
Human osteoclasts, not osteoblasts, deposit osteopontin onto resorption surfaces: an in vitro and ex vivo study of remodeling bone.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1995;10(11):1666-80.
1994: S Walsh; RA Dodds; Ian E James; JN Bradbeer; Maxine Gowen
Monoclonal antibodies with selective reactivity against osteoblasts and osteocytes in human bone.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1994;9(11):1687-96.
1991: Ian E James; S Walsh; RA Dodds; Maxine Gowen
Production and characterization of osteoclast-selective monoclonal antibodies that distinguish between multinucleated cells derived from different human tissues.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1991;39(7):905-14.