FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Leo James

Research Profile

Concepts & Ideas

Chemicals & Drugs

Procedures

X Ray Crystallography

Genes & Molecular Sequences

Amino Acid Sequences

Phenomena

Living Beings

Mouse

Anatomy

Cell Line

Co-author Network

Publications

TOP 3
Felix Randow; John D MacMicking; Leo C James
Cellular self-defense: how cell-autonomous immunity protects against pathogens.
William A McEwan; Jerry C H Tam; Ruth E Watkinson; Susanna R Bidgood; Donna L Mallery; Leo C James
Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21.
Maxime Veillette; Katsiaryna Bichel; Stefan M V Freund; Leo C James; Paulina Pawlica; Quang Toan Pham; Mélodie B Plourde; Carlos Reyes-Moreno; Lionel Berthoux
The V86M mutation in HIV-1 capsid confers resistance to TRIM5α by abrogation of cyclophilin A-dependent restriction and enhancement of viral nuclear import.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Leo James (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Felix Randow; John D MacMicking; Leo C James
Cellular self-defense: how cell-autonomous immunity protects against pathogens.
Science (New York, N.Y.) 2013;340(6133):701-6.
2013: William A McEwan; Jerry C H Tam; Ruth E Watkinson; Susanna R Bidgood; Donna L Mallery; Leo C James
Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21.
Nature immunology 2013;14(4):327-36.
2013: Maxime Veillette; Katsiaryna Bichel; Stefan M V Freund; Leo C James; Paulina Pawlica; Quang Toan Pham; Mélodie B Plourde; Carlos Reyes-Moreno; Lionel Berthoux
The V86M mutation in HIV-1 capsid confers resistance to TRIM5α by abrogation of cyclophilin A-dependent restriction and enhancement of viral nuclear import.
Retrovirology 2013;10():25.
2012: Felix Hauler; Donna L Mallery; William A McEwan; Susanna R Bidgood; Leo C James
AAA ATPase p97/VCP is essential for TRIM21-mediated virus neutralization.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(48):19733-8.
2012: W A McEwan; C R Williams; Donna L Mallery; S R Bidgood; R A Crowther; F Hauler; Leo C James
Regulation of virus neutralization and the persistent fraction by TRIM21.
Journal of virology 2012;86(16):8482-91.
2012: Matthew E C Caines; Stefan M V Freund; Katsiaryna Bichel; William A McEwan; Amanda J Price; Greg J Towers; Brian J Willett; Leo C James
Diverse HIV viruses are targeted by a conformationally dynamic antiviral.
Nature structural & molecular biology 2012;19(4):411-6.
2012: Amanda J Price; Torsten Schaller; Greg J Towers; Vineet N KewalRamani; KyeongEun Lee; Jason W Chin; Tom Elliott; Adam J Fletcher; Leo C James
CPSF6 defines a conserved capsid interface that modulates HIV-1 replication.
PLoS pathogens 2012;8(8):e1002896.
2011: William A McEwan; David A Rhodes; John Trowsdale; Donna L Mallery; Leo C James
Intracellular antibody-mediated immunity and the role of TRIM21.
BioEssays : news and reviews in molecular, cellular and developmental biology 2011;33(11):803-9.
2010: Donna L Mallery; William A McEwan; Susanna R Bidgood; Greg J Towers; Chris M Johnson; Leo C James
Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21).
Proceedings of the National Academy of Sciences of the United States of America 2010;107(46):19985-90.
2010: Michael Lammers; Heinz Neumann; Jason W Chin; Leo C James
Acetylation regulates cyclophilin A catalysis, immunosuppression and HIV isomerization.
Nature chemical biology 2010;6(5):331-7.
2010: Laura M J Ylinen; Amanda J Price; Jane Rasaiyaah; Stéphane Hué; Nicola J Rose; Flavia Marzetta; Leo C James; Greg J Towers
Conformational adaptation of Asian macaque TRIMCyp directs lineage specific antiviral activity.
PLoS pathogens 2010;6(8):e1001062.
2009: Amanda J Price; Flavia Marzetta; Michael Lammers; Laura M J Ylinen; Torsten Schaller; Sam J Wilson; Greg J Towers; Leo C James
Active site remodeling switches HIV specificity of antiretroviral TRIMCyp.
Nature structural & molecular biology 2009;16(10):1036-42.
2008: Anthony H Keeble; Zahra Khan; Alan Forster; Leo C James
TRIM21 is an IgG receptor that is structurally, thermodynamically, and kinetically conserved.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(16):6045-50.
2007: Leo C James; Phil C Jones; Airlie McCoy; Glenys A Tennent; Mark B Pepys; Kristoffer Famm; Greg Winter
Beta-edge interactions in a pentadecameric human antibody V kappa domain.
Journal of molecular biology 2007;367(3):603-8.
2005: Leo C James; Dan S Tawfik
Structure and kinetics of a transient antibody binding intermediate reveal a kinetic discrimination mechanism in antigen recognition.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(36):12730-5.
2004: Laurent Jespers; Oliver Schon; Leo C James; Dmitri Veprintsev; Greg Winter
Crystal structure of HEL4, a soluble, refoldable human V(H) single domain with a germ-line scaffold.
Journal of molecular biology 2004;337(4):893-903.
2003: Leo C James; Dan S Tawfik
The specificity of cross-reactivity: promiscuous antibody binding involves specific hydrogen bonds rather than nonspecific hydrophobic stickiness.
Protein science : a publication of the Protein Society 2003;12(10):2183-93.
2003: Leo C James; Dan S Tawfik
Conformational diversity and protein evolution--a 60-year-old hypothesis revisited.
Trends in biochemical sciences 2003;28(7):361-8.
2003: Leo C James; Pietro Roversi; Dan S Tawfik
Antibody multispecificity mediated by conformational diversity.
Science (New York, N.Y.) 2003;299(5611):1362-7.
2001: Leo C James; Dan S Tawfik
Catalytic and binding poly-reactivities shared by two unrelated proteins: The potential role of promiscuity in enzyme evolution.
Protein science : a publication of the Protein Society 2001;10(12):2600-7.
1999: Leo C James; G Hale; H Waldmann; AC Bloomer; H Waldman
1.9 A structure of the therapeutic antibody CAMPATH-1H fab in complex with a synthetic peptide antigen.
Journal of molecular biology 1999;289(2):293-301.