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Michael James

Research Profile

Procedures

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Chemicals & Drugs

Genes & Molecular Sequences

Amino Acid Sequences

Phenomena

Living Beings

Mycobacterium tuberculosis

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Tamara D Skene-Arnold; Laura Trinkle-Mulcahy; R Glen Uhrig; Veerle De Wever; Andrea Fong; Michael N G James; Hue Anh Luu; Jason T Maynes; Greg B G Moorhead; Mhairi Nimick; Charles F B Holmes
Molecular mechanisms underlying the interaction of protein phosphatase-1c with ASPP proteins.
Pravas Kumar Baral; Adriano Aguzzi; Nat N V Kav; Magdalini Polymenidou; Muhammad Hafiz Rahman; Mridula Swayampakula; Barbara Wieland; Michael N G James
Structural studies on the folded domain of the human prion protein bound to the Fab fragment of the antibody POM1.
Kayla Baretta; Craig Garen; Jiang Yin; Michael N G James
Expression, purification, crystallization and preliminary crystallographic analysis of the phosphoglycerate kinase from Acinetobacter baumannii.

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All Publications

2013: Tamara D Skene-Arnold; Laura Trinkle-Mulcahy; R Glen Uhrig; Veerle De Wever; Andrea Fong; Michael N G James; Hue Anh Luu; Jason T Maynes; Greg B G Moorhead; Mhairi Nimick; Charles F B Holmes
Molecular mechanisms underlying the interaction of protein phosphatase-1c with ASPP proteins.
The Biochemical journal 2013;449(3):649-59.
2012: Pravas Kumar Baral; Adriano Aguzzi; Nat N V Kav; Magdalini Polymenidou; Muhammad Hafiz Rahman; Mridula Swayampakula; Barbara Wieland; Michael N G James
Structural studies on the folded domain of the human prion protein bound to the Fab fragment of the antibody POM1.
Acta crystallographica. Section D, Biological crystallography 2012;68(Pt 11):1501-12.
2012: Kayla Baretta; Craig Garen; Jiang Yin; Michael N G James
Expression, purification, crystallization and preliminary crystallographic analysis of the phosphoglycerate kinase from Acinetobacter baumannii.
Acta crystallographica. Section F, Structural biology and crystallization communications 2012;68(Pt 7):790-2.
2012: Maia M Cherney; Michael N G James; Yanfei Zhang; Joel H Weiner
Structure-activity characterization of sulfide:quinone oxidoreductase variants.
Journal of structural biology 2012;178(3):319-28.
2011: Chunying Niu; Jiang Yin; Maia M Cherney; Michael N G James
Expression, purification and preliminary crystallographic analysis of Rv2247, the β subunit of acyl-CoA carboxylase (ACCD6) from Mycobacterium tuberculosis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2011;67(Pt 12):1637-40.
2011: Maia M Cherney; Craig Garen; Leonid T Cherney; Michael N G James
The structures of Thermoplasma volcanium phosphoribosyl pyrophosphate synthetase bound to ribose-5-phosphate and ATP analogs.
Journal of molecular biology 2011;413(4):844-56.
2011: Nobuhiko Watanabe; Michael N G James
Structural insights for the substrate recognition mechanism of LL-diaminopimelate aminotransferase.
Biochimica et biophysica acta 2011;1814(11):1528-33.
2011: Pravas Kumar Baral; Adriano Aguzzi; Nat N V Kav; Magdalini Polymenidou; Mridula Swayampakula; Barbara Wieland; Michael N G James
Crystallization and preliminary X-ray diffraction analysis of prion protein bound to the Fab fragment of the POM1 antibody.
Acta crystallographica. Section F, Structural biology and crystallization communications 2011;67(Pt 10):1211-3.
2011: Sowmya Krishnaswamy; Pravas Kumar Baral; Michael N G James; Nat N V Kav
Site-directed mutagenesis of histidine 69 and glutamic acid 148 alters the ribonuclease activity of pea ABR17 (PR10.4).
Plant physiology and biochemistry : PPB / Société française de physiologie végétale 2011;49(9):958-62.
2011: Nobuhiko Watanabe; Matthew D Clay; Chenguang Fan; Marco J van Belkum; John C Vederas; Michael N G James
The structure of LL-diaminopimelate aminotransferase from Chlamydia trachomatis: implications for its broad substrate specificity.
Journal of molecular biology 2011;411(3):649-60.
2011: Jiang Yin; Minmin Yu; Emily Z Alipio Lyon; Chang-Yub Kim; Heungbok Kim; Katherine Bateman; Craig Garen; Jeff Habel; Li-Wei Hung; Michael N G James
Expression, purification and preliminary crystallographic analysis of O-acetylhomoserine sulfhydrylase from Mycobacterium tuberculosis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2011;67(Pt 8):959-63.
2011: Jiang Yin; Craig Garen; Grace Garen; Michael N G James
Expression, purification and preliminary crystallographic analysis of Rv3002c, the regulatory subunit of acetolactate synthase (IlvH) from Mycobacterium tuberculosis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2011;67(Pt 8):933-6.
2011: Maia M Cherney; Fabien Lecaille; Martin Kienitz; Ferez Nallaseth; Zhenqiang Li; Michael N G James; Dieter Brömme
Structure-activity analysis of cathepsin K/chondroitin 4-sulfate interactions.
The Journal of biological chemistry 2011;286(11):8988-98.
2011: Katherine S Bateman; Maia M Cherney; Don J Mahuran; Michael Tropak; Michael N G James
Crystal structure of β-hexosaminidase B in complex with pyrimethamine, a potential pharmacological chaperone.
Journal of medicinal chemistry 2011;54(5):1421-9.
2011: Nicholas Chim; Jeff E Habel; Jodie M Johnston; Inna Krieger; linda miallau; Ramasamy Sankaranarayanan; Robert P Morse; John Bruning; Stephanie Swanson; Haelee Kim; Chang-Yub Kim; Hongye Li; Esther M Bulloch; Richard J Payne; Alexandra Manos-Turvey; Li-Wei Hung; Edward N Baker; J Shaun Lott; Michael N G James; Thomas C Terwilliger; David S Eisenberg; James C Sacchettini; Celia W Goulding
The TB Structural Genomics Consortium: a decade of progress.
Tuberculosis (Edinburgh, Scotland) 2011;91(2):155-72.
2010: Márcia Y Kondo; Débora N Okamoto; Jorge A N Santos; Maria A Juliano; Kohei Oda; Bindu Pillai; Michael N G James; Luiz Juliano; Iuri E Gouvea
Studies on the catalytic mechanism of a glutamic peptidase.
The Journal of biological chemistry 2010;285(28):21437-45.
2010: Leonid T Cherney; Maia M Cherney; Craig Garen; Michael N G James
Crystal structure of the intermediate complex of the arginine repressor from Mycobacterium tuberculosis bound with its DNA operator reveals detailed mechanism of arginine repression.
Journal of molecular biology 2010;399(2):240-54.
2010: Maia M Cherney; Yanfei Zhang; Matthew Solomonson; Joel Weiner; Michael N G James
Crystal structure of sulfide:quinone oxidoreductase from Acidithiobacillus ferrooxidans: insights into sulfidotrophic respiration and detoxification.
Journal of molecular biology 2010;398(2):292-305.
2010: Ramasamy Sankaranarayanan; Maia M Cherney; Craig Garen; Grace Garen; Chunying Niu; Marshall Yuan; Michael N G James
The molecular structure of ornithine acetyltransferase from Mycobacterium tuberculosis bound to ornithine, a competitive inhibitor.
Journal of molecular biology 2010;397(4):979-90.
2009: Michael N G James; Jiang Yin
Regulatory RNA elements. Preface.
Biochimica et biophysica acta 2009;1789(9-10):493-4.
2009: Yanfei Zhang; Maia M Cherney; Matthew Solomonson; Jianshe Liu; Michael N G James; Joel Weiner
Preliminary X-ray crystallographic analysis of sulfide:quinone oxidoreductase from Acidithiobacillus ferrooxidans.
Acta crystallographica. Section F, Structural biology and crystallization communications 2009;65(Pt 8):839-42.
2009: Leonid T Cherney; Maia M Cherney; Craig Garen; Michael N G James
The structure of the arginine repressor from Mycobacterium tuberculosis bound with its DNA operator and Co-repressor, L-arginine.
Journal of molecular biology 2009;388(1):85-97.
2009: Bindu Pillai; Vijayalakshmi A Moorthie; Marco J van Belkum; Sandra L Marcus; Maia M Cherney; Christopher M Diaper; John C Vederas; Michael N G James
Crystal structure of diaminopimelate epimerase from Arabidopsis thaliana, an amino acid racemase critical for L-lysine biosynthesis.
Journal of molecular biology 2009;385(2):580-94.
2008: Leonid T Cherney; Maia M Cherney; Craig Garen; George J Lu; Michael N G James
Crystal structure of the arginine repressor protein in complex with the DNA operator from Mycobacterium tuberculosis.
Journal of molecular biology 2008;384(5):1330-40.
2008: Nobuhiko Watanabe; Matthew D Clay; Marco J van Belkum; Maia M Cherney; John C Vederas; Michael N G James
Mechanism of substrate recognition and PLP-induced conformational changes in LL-diaminopimelate aminotransferase from Arabidopsis thaliana.
Journal of molecular biology 2008;384(5):1314-29.
2008: Maia M Cherney; Craig Garen; Michael N G James
Crystal structure of Mycobacterium tuberculosis Rv0760c at 1.50 A resolution, a structural homolog of Delta(5)-3-ketosteroid isomerase.
Biochimica et biophysica acta 2008;1784(11):1625-32.
2008: Zhenqiang Li; Martin Kienetz; Maia M Cherney; Michael N G James; Dieter Brömme
The crystal and molecular structures of a cathepsin K:chondroitin sulfate complex.
Journal of molecular biology 2008;383(1):78-91.
2008: Jianmin Zhang; Carly Huitema; Chunying Niu; Jiang Yin; Michael N G James; Lindsay D Eltis; John C Vederas
Aryl methylene ketones and fluorinated methylene ketones as reversible inhibitors for severe acute respiratory syndrome (SARS) 3C-like proteinase.
Bioorganic chemistry 2008;36(5):229-40.
2008: Bichitra K Biswal; Christophe Morisseau; Grace Garen; Maia M Cherney; Craig Garen; Chunying Niu; Bruce D Hammock; Michael N G James
The molecular structure of epoxide hydrolase B from Mycobacterium tuberculosis and its complex with a urea-based inhibitor.
Journal of molecular biology 2008;381(4):897-912.
2008: Jiang Yin; Craig Garen; Maia M Cherney; Leonid T Cherney; Michael N G James
Expression, purification and preliminary crystallographic analysis of N-acetylglucosamine-1-phosphate uridylyltransferase from Mycobacterium tuberculosis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2008;64(Pt 9):805-8.
2008: Leonid T Cherney; Maia M Cherney; Craig Garen; George J Lu; Michael N G James
Structure of the C-terminal domain of the arginine repressor protein from Mycobacterium tuberculosis.
Acta crystallographica. Section D, Biological crystallography 2008;64(Pt 9):950-6.
2008: Sarah J Witholt; Ramasamy Sankaranarayanan; Craig Garen; Maia M Cherney; Leonid T Cherney; Michael N G James
Expression, purification, crystallization and preliminary X-ray analysis of Rv3117, a probable thiosulfate sulfurtransferase (CysA3) from Mycobacterium tuberculosis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2008;64(Pt 6):541-4.
2008: Carly Huitema; Jianmin Zhang; Jiang Yin; Michael N G James; John C Vederas; Lindsay D Eltis
Heteroaromatic ester inhibitors of hepatitis A virus 3C proteinase: Evaluation of mode of action.
Bioorganic & medicinal chemistry 2008;16(10):5761-77.
2008: Ting-Wai Lee; Michael N G James
1.2A-resolution crystal structures reveal the second tetrahedral intermediates of streptogrisin B (SGPB).
Biochimica et biophysica acta 2008;1784(2):319-34.
2008: Pooja A Mazumdar; Jordan C Hulecki; Maia M Cherney; Craig Garen; Michael N G James
X-ray crystal structure of Mycobacterium tuberculosis haloalkane dehalogenase Rv2579.
Biochimica et biophysica acta 2008;1784(2):351-62.
2008: Ramasamy Sankaranarayanan; Maia M Cherney; Leonid T Cherney; Craig Garen; Fatemeh Moradian; Michael N G James
The crystal structures of ornithine carbamoyltransferase from Mycobacterium tuberculosis and its ternary complex with carbamoyl phosphate and L-norvaline reveal the enzyme's catalytic mechanism.
Journal of molecular biology 2008;375(4):1052-63.
2008: Magdalini Polymenidou; Rita Moos; Mike Scott; Christina J Sigurdson; Yong-Zhong Shi; Bill Yajima; Iva Hafner Bratkovič; Roman Jerala; Simone Hornemann; Kurt Wuthrich; Anne Bellon; Martin Vey; Graciela Garen; Michael N G James; Nat Kav; Adriano Aguzzi
The POM monoclonals: a comprehensive set of antibodies to non-overlapping prion protein epitopes.
PloS one 2008;3(12):e3872.
2008: Chunying Niu; Jiang Yin; Jianmin Zhang; John C Vederas; Michael N G James
Molecular docking identifies the binding of 3-chloropyridine moieties specifically to the S1 pocket of SARS-CoV Mpro.
Bioorganic & medicinal chemistry 2008;16(1):293-302.
2007: Bindu Pillai; Maia M Cherney; Christopher M Diaper; Andrew Sutherland; John S Blanchard; John C Vederas; Michael N G James
Dynamics of catalysis revealed from the crystal structures of mutants of diaminopimelate epimerase.
Biochemical and biophysical research communications 2007;363(3):547-53.
2007: George J Lu; Craig Garen; Maia M Cherney; Leonid T Cherney; Cecilia Lee; Michael N G James
Expression, purification and preliminary X-ray analysis of the C-terminal domain of an arginine repressor protein from Mycobacterium tuberculosis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 11):936-9.
2007: Jiang Yin; Chunying Niu; Maia M Cherney; Jianmin Zhang; Carly Huitema; Lindsay D Eltis; John C Vederas; Michael N G James
A mechanistic view of enzyme inhibition and peptide hydrolysis in the active site of the SARS-CoV 3C-like peptidase.
Journal of molecular biology 2007;371(4):1060-74.
2007: Nobuhiko Watanabe; Maia M Cherney; Marco J van Belkum; Sandra L Marcus; Mitchel D Flegel; Matthew D Clay; Michael K Deyholos; John C Vederas; Michael N G James
Crystal structure of LL-diaminopimelate aminotransferase from Arabidopsis thaliana: a recently discovered enzyme in the biosynthesis of L-lysine by plants and Chlamydia.
Journal of molecular biology 2007;371(3):685-702.
2007: A C Murillo; H Y Li; Thomas Alber; Edward N Baker; James M Berger; Leonid T Cherney; M M Cherney; Yoon Song Cho; David Eisenberg; Craig Garen; Celia W Goulding; Li-Wei Hung; Thomas R Ioerger; William R. Jacobs Jr.; Michael N G James; C Kim; I Krieger; J S Lott; R Sankaranarayanan; Brent W Segelke; Thomas C Terwilliger; F Wang; S Wang; James C Sacchettini
High throughput crystallography of TB drug targets.
Infectious disorders drug targets 2007;7(2):127-39.
2007: Jianmin Zhang; Hanna I Pettersson; Carly Huitema; Chunying Niu; Jiang Yin; Michael N G James; Lindsay D Eltis; John C Vederas
Design, synthesis, and evaluation of inhibitors for severe acute respiratory syndrome 3C-like protease based on phthalhydrazide ketones or heteroaromatic esters.
Journal of medicinal chemistry 2007;50(8):1850-64.
2007: Leonid T Cherney; Maia M Cherney; Craig Garen; Chunying Niu; Fatemeh Moradian; Michael N G James
Crystal structure of N-acetyl-gamma-glutamyl-phosphate reductase from Mycobacterium tuberculosis in complex with NADP(+).
Journal of molecular biology 2007;367(5):1357-69.
2007: Ting-Wai Lee; MA Qasim; Michael Laskowski; Michael N G James
Structural insights into the non-additivity effects in the sequence-to-reactivity algorithm for serine peptidases and their inhibitors.
Journal of molecular biology 2007;367(2):527-46.
2007: Enrico Weidauer; Yoshiyuki Yasuda; Bichitra K Biswal; Maia Cherny; Michael N G James; Dieter Brömme
Effects of disease-modifying anti-rheumatic drugs (DMARDs) on the activities of rheumatoid arthritis-associated cathepsins K and S.
Biological chemistry 2007;388(3):331-6.
2007: Ting-Wai Lee; Maia M Cherney; Jie Liu; Karen Ellis James; James C Powers; Lindsay D Eltis; Michael N G James
Crystal structures reveal an induced-fit binding of a substrate-like Aza-peptide epoxide to SARS coronavirus main peptidase.
Journal of molecular biology 2007;366(3):916-32.
2007: M Joanne Lemieux; Sarah J Fischer; Maia M Cherney; Katherine S Bateman; Michael N G James
The crystal structure of the rhomboid peptidase from Haemophilus influenzae provides insight into intramembrane proteolysis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(3):750-4.
2007: Bindu Pillai; Maia M Cherney; Kazumi Hiraga; Katsumi Takada; Kohei Oda; Michael N G James
Crystal structure of scytalidoglutamic peptidase with its first potent inhibitor provides insights into substrate specificity and catalysis.
Journal of molecular biology 2007;365(2):343-61.
2006: Craig Garen; Maia M Cherney; Ernst M Bergmann; Michael N G James
The molecular structure of Rv1873, a conserved hypothetical protein from Mycobacterium tuberculosis, at 1.38 A resolution.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 12):1201-5.
2006: Fatemeh Moradian; Craig Garen; Leonid T Cherney; Maia M Cherney; Michael N G James
Expression, purification, crystallization and preliminary X-ray analysis of two arginine-biosynthetic enzymes from Mycobacterium tuberculosis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 10):986-8.
2006: Jiang Yin; Maia M Cherney; Ernst M Bergmann; Jianmin Zhang; Carly Huitema; Hanna I Pettersson; Lindsay D Eltis; John C Vederas; Michael N G James
An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors.
Journal of molecular biology 2006;361(4):673-86.
2006: Bichitra K Biswal; Meitian Wang; Maia M Cherney; Laval Chan; Constantin G Yannopoulos; Darius Bilimoria; Jean Bedard; Michael N G James
Non-nucleoside inhibitors binding to hepatitis C virus NS5B polymerase reveal a novel mechanism of inhibition.
Journal of molecular biology 2006;361(1):33-45.
2006: Michael N G James
The peptidases from fungi and viruses.
Biological chemistry 2006;387(8):1023-9.
2006: Bichitra K Biswal; Karolyn Au; Maia M Cherney; Craig Garen; Michael N G James
The molecular structure of Rv2074, a probable pyridoxine 5'-phosphate oxidase from Mycobacterium tuberculosis, at 1.6 angstroms resolution.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 8):735-42.
2006: Marie E Fraser; Maia M Cherney; Paola Marcato; George L Mulvey; Glen D Armstrong; Michael N G James
Binding of adenine to Stx2, the protein toxin from Escherichia coli O157:H7.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 7):627-30.
2006: M Joanne Lemieux; Brian L Mark; Maia M Cherney; Stephen G Withers; Don J Mahuran; Michael N G James
Crystallographic structure of human beta-hexosaminidase A: interpretation of Tay-Sachs mutations and loss of GM2 ganglioside hydrolysis.
Journal of molecular biology 2006;359(4):913-29.
2006: Bindu Pillai; Maia M Cherney; Christopher M Diaper; Andrew Sutherland; John S Blanchard; John C Vederas; Michael N G James
Structural insights into stereochemical inversion by diaminopimelate epimerase: an antibacterial drug target.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(23):8668-73.
2006: Jiang Yin; Linda X Xu; Maia M Cherney; Evelyne Raux-Deery; Amanda A Bindley; Alexei Savchenko; John R Walker; Marianne E Cuff; Martin J Warren; Michael N G James
Crystal structure of the vitamin B12 biosynthetic cobaltochelatase, CbiXS, from Archaeoglobus fulgidus.
Journal of structural and functional genomics 2006;7(1):37-50.
2006: Jason T Maynes; Hue Anh Luu; Maia M Cherney; Raymond J Andersen; David Williams; Charles F B Holmes; Michael N G James
Crystal structures of protein phosphatase-1 bound to motuporin and dihydromicrocystin-LA: elucidation of the mechanism of enzyme inhibition by cyanobacterial toxins.
Journal of molecular biology 2006;356(1):111-20.
2006: Bichitra K Biswal; Grace Garen; Maia M Cherney; Craig Garen; Michael N G James
Cloning, expression, purification, crystallization and preliminary X-ray studies of epoxide hydrolases A and B from Mycobacterium tuberculosis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 2):136-8.
2005: Christopher M Diaper; Andrew Sutherland; Bindu Pillai; Michael N G James; Paul Semchuk; John S Blanchard; John C Vederas
The stereoselective synthesis of aziridine analogues of diaminopimelic acid (DAP) and their interaction with dap epimerase.
Organic & biomolecular chemistry 2005;3(24):4402-11.
2005: Jiang Yin; Ernst M Bergmann; Maia M Cherney; Manjinder S Lall; Rajendra P Jain; John C Vederas; Michael N G James
Dual modes of modification of hepatitis A virus 3C protease by a serine-derived beta-lactone: selective crystallization and formation of a functional catalytic triad in the active site.
Journal of molecular biology 2005;354(4):854-71.
2005: M Joanne Lemieux; Claire Ference; Maia M Cherney; Metian Wang; Craig Garen; Michael N G James
The crystal structure of Rv0793, a hypothetical monooxygenase from M. tuberculosis.
Journal of structural and functional genomics 2005;6(4):245-57.
2005: Ting-Wai Lee; Maia M Cherney; Carly Huitema; Jie Liu; Karen Ellis James; James C Powers; Lindsay D Eltis; Michael N G James
Crystal structures of the main peptidase from the SARS coronavirus inhibited by a substrate-like aza-peptide epoxide.
Journal of molecular biology 2005;353(5):1137-51.
2005: Bichitra K Biswal; Maia M Cherney; Meitian Wang; Craig Garen; Michael N G James
Structures of Mycobacterium tuberculosispyridoxine 5'-phosphate oxidase and its complexes with flavin mononucleotide and pyridoxal 5'-phosphate.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 11):1492-9.
2005: Yukiko Kataoka; Katsumi Takada; Hiroshi Oyama; Masahiko Tsunemi; Michael N G James; Kohei Oda
Catalytic residues and substrate specificity of scytalidoglutamic peptidase, the first member of the eqolisin in family (G1) of peptidases.
FEBS letters 2005;579(14):2991-4.
2005: Bichitra K Biswal; Maia M Cherney; Meitian Wang; Laval Chan; Constantin G Yannopoulos; Darius Bilimoria; Olivier Nicolas; Jean Bedard; Michael N G James
Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors.
The Journal of biological chemistry 2005;280(18):18202-10.
2005: Jason T Maynes; Maia M Cherney; MA Qasim; Michael Laskowski; Michael N G James
Structure of the subtilisin Carlsberg-OMTKY3 complex reveals two different ovomucoid conformations.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 5):580-8.
2004: Rajendra P Jain; Hanna I Pettersson; Jianmin Zhang; Katherine D Aull; Pascal D Fortin; Carly Huitema; Lindsay D Eltis; Jonathan C Parrish; Michael N G James; David S Wishart; John C Vederas
Synthesis and evaluation of keto-glutamine analogues as potent inhibitors of severe acute respiratory syndrome 3CLpro.
Journal of medicinal chemistry 2004;47(25):6113-6.
2004: Jason T Maynes; Kathleen R Perreault; Maia M Cherney; Hue Anh Luu; Michael N G James; Charles F B Holmes
Crystal structure and mutagenesis of a protein phosphatase-1:calcineurin hybrid elucidate the role of the beta12-beta13 loop in inhibitor binding.
The Journal of biological chemistry 2004;279(41):43198-206.
2004: Marie E Fraser; Masao Fujinaga; Maia M Cherney; Angela R Melton-Celsa; Edda M Twiddy; Alison D O'Brien; Michael N G James
Structure of shiga toxin type 2 (Stx2) from Escherichia coli O157:H7.
The Journal of biological chemistry 2004;279(26):27511-7.
2004: Masao Fujinaga; Maia M Cherney; Hiroshi Oyama; Kohei Oda; Michael N G James
The molecular structure and catalytic mechanism of a novel carboxyl peptidase from Scytalidium lignicolum.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(10):3364-9.
2003: Jason T Maynes; Craig Garen; Maia M Cherney; Gerald Newton; Dorit Arad; Yossef Av-Gay; Robert C Fahey; Michael N G James
The crystal structure of 1-D-myo-inosityl 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) from Mycobacterium tuberculosis reveals a zinc hydrolase with a lactate dehydrogenase fold.
The Journal of biological chemistry 2003;278(47):47166-70.
2003: Isabelle H Barrette-Ng; Kenneth K-S Ng; Maia M Cherney; Gregory Pearce; Usman Ghani; Clarence A Ryan; Michael N G James
Unbound form of tomato inhibitor-II reveals interdomain flexibility and conformational variability in the reactive site loops.
The Journal of biological chemistry 2003;278(33):31391-400.
2003: Isabelle H Barrette-Ng; Kenneth K-S Ng; Maia M Cherney; Gregory Pearce; Clarence A Ryan; Michael N G James
Structural basis of inhibition revealed by a 1:2 complex of the two-headed tomato inhibitor-II and subtilisin Carlsberg.
The Journal of biological chemistry 2003;278(26):24062-71.
2003: Nina K Bernstein; Maia M Cherney; Charles A Yowell; John B Dame; Michael N G James
Structural insights into the activation of P. vivax plasmepsin.
Journal of molecular biology 2003;329(3):505-24.
2003: Brian L Mark; Don J Mahuran; Maia M Cherney; Dalian Zhao; Spencer Knapp; Michael N G James
Crystal structure of human beta-hexosaminidase B: understanding the molecular basis of Sandhoff and Tay-Sachs disease.
Journal of molecular biology 2003;327(5):1093-109.
2003: Meitian Wang; Kenneth K-S Ng; Maia M Cherney; Laval Chan; Constantin G Yannopoulos; Jean Bedard; Nicolas Morin; Nghe Nguyen-Ba; Moulay H Alaoui-Ismaili; Richard Bethell; Michael N G James
Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibition.
The Journal of biological chemistry 2003;278(11):9489-95.
2002: Eiko Toyota; Kenneth K-S Ng; Shiro Kuninaga; Haruo Sekizaki; Kunihiko Itoh; Kazutaka Tanizawa; Michael N G James
Crystal structure and nucleotide sequence of an anionic trypsin from chum salmon (Oncorhynchus keta) in comparison with Atlantic salmon (Salmo salar) and bovine trypsin.
Journal of molecular biology 2002;324(3):391-7.
2002: Charles F B Holmes; Jason T Maynes; Kathleen R Perreault; JF Dawson; Michael N G James
Molecular enzymology underlying regulation of protein phosphatase-1 by natural toxins.
Current medicinal chemistry 2002;9(22):1981-9.
2002: Spencer J Williams; Brian L Mark; David J Vocadlo; Michael N G James; Stephen G Withers
Aspartate 313 in the Streptomyces plicatus hexosaminidase plays a critical role in substrate-assisted catalysis by orienting the 2-acetamido group and stabilizing the transition state.
The Journal of biological chemistry 2002;277(42):40055-65.
2002: Isabelle H Barrette-Ng; Kenneth K-S Ng; Brian L Mark; Danny Van Aken; Maia M Cherney; Craig Garen; Yuliya Kolodenko; Alexander E Gorbalenya; Eric J Snijder; Michael N G James
Structure of arterivirus nsp4. The smallest chymotrypsin-like proteinase with an alpha/beta C-terminal extension and alternate conformations of the oxyanion hole.
The Journal of biological chemistry 2002;277(42):39960-6.
2002: Yeeman K Ramtohul; Michael N G James; John C Vederas
Synthesis and evaluation of keto-glutamine analogues as inhibitors of hepatitis A virus 3C proteinase.
The Journal of organic chemistry 2002;67(10):3169-78.
2002: Manjinder S Lall; Yeeman K Ramtohul; Michael N G James; John C Vederas
Serine and threonine beta-lactones: a new class of hepatitis A virus 3C cysteine proteinase inhibitors.
The Journal of organic chemistry 2002;67(5):1536-47.
2002: Kenneth K-S Ng; Maia M Cherney; Ana Lopez Vazquez; Angeles Machin; Jose M Martin Alonso; Francisco Parra; Michael N G James
Crystal structures of active and inactive conformations of a caliciviral RNA-dependent RNA polymerase.
The Journal of biological chemistry 2002;277(2):1381-7.
2001: Usman Ghani; Kenneth K-S Ng; M Iqbal Choudhary; N Ullah; Michael N G James
Crystal structure of gamma-chymotrypsin in complex with 7-hydroxycoumarin.
Journal of molecular biology 2001;314(3):519-25.
2001: Jason T Maynes; K S Bateman; Maia M Cherney; A K Das; Hue Anh Luu; Charles F B Holmes; Michael N G James
Crystal structure of the tumor-promoter okadaic acid bound to protein phosphatase-1.
The Journal of biological chemistry 2001;276(47):44078-82.
2001: Brian L Mark; David J Vocadlo; D Zhao; Spencer Knapp; Stephen G Withers; Michael N G James
Biochemical and structural assessment of the 1-N-azasugar GalNAc-isofagomine as a potent family 20 beta-N-acetylhexosaminidase inhibitor.
The Journal of biological chemistry 2001;276(45):42131-7.
2001: B L Mark; Jonathan C Parrish; ZX Wang; Leonard I Wiebe; Edward E Knaus; Michael N G James
(E)-1-(2'-deoxy-beta-D-ribofuranosyl)-2,4-difluoro-5-(2-iodovinyl)benzene.
Acta crystallographica. Section C, Crystal structure communications 2001;57(Pt 6):758-60.
2001: Brian L Mark; David J Vocadlo; Spencer Knapp; Barbara L Triggs-Raine; Stephen G Withers; Michael N G James
Crystallographic evidence for substrate-assisted catalysis in a bacterial beta-hexosaminidase.
The Journal of biological chemistry 2001;276(13):10330-7.
2001: Stephen M Lu; Wuyuan Lu; MA Qasim; Stephen Anderson; I Apostol; W Ardelt; T Bigler; Yi-Wen Chiang; J Cook; Michael N G James; I Kato; C Kelly; W Kohr; T Komiyama; T Y Lin; M Ogawa; J Otlewski; S J Park; Sabiha Qasim; Michael Ranjbar; M Tashiro; Nicholas Warne; H Whatley; A Wieczorek; M Wieczorek; T Wilusz; R Wynn; Wei Zhang; Michael Laskowski
Predicting the reactivity of proteins from their sequence alone: Kazal family of protein inhibitors of serine proteinases.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1410-5.
2001: KS Bateman; K Huang; S Anderson; Wuyuan Lu; MA Qasim; Michael Laskowski; Michael N G James
Contribution of peptide bonds to inhibitor-protease binding: crystal structures of the turkey ovomucoid third domain backbone variants OMTKY3-Pro18I and OMTKY3-psi[COO]-Leu18I in complex with Streptomyces griseus proteinase B (SGPB) and the structure of the free inhibitor, OMTKY-3-psi[CH2NH2+]-Asp19I.
Journal of molecular biology 2001;305(4):839-49.
2001: Eiko Toyota; Kenneth K-S Ng; Haruo Sekizaki; Kunihiko Itoh; Kazutaka Tanizawa; Michael N G James
X-ray crystallographic analyses of complexes between bovine beta-trypsin and Schiff base copper(II) or iron(III) chelates.
Journal of molecular biology 2001;305(3):471-9.
2000: Jean-Christophe Rochet; Edward R Brownie; K Oikawa; Leslie D Hicks; Marie E Fraser; Michael N G James; Cyril M Kay; WA Bridger; William T Wolodko
Pig heart CoA transferase exists as two oligomeric forms separated by a large kinetic barrier.
Biochemistry 2000;39(37):11291-302.
2000: Kenneth K-S Ng; JF Petersen; Maia M Cherney; Craig Garen; J J Zalatoris; C Rao-Naik; Ben M Dunn; M R Martzen; R J Peanasky; Michael N G James
Structural basis for the inhibition of porcine pepsin by Ascaris pepsin inhibitor-3.
Nature structural biology 2000;7(8):653-7.
2000: Marie E Fraser; Michael N G James; WA Bridger; William T Wolodko
Phosphorylated and dephosphorylated structures of pig heart, GTP-specific succinyl-CoA synthetase.
Journal of molecular biology 2000;299(5):1325-39.
2000: Masao Fujinaga; Maia M Cherney; NI Tarasova; Paul A Bartlett; J E Hanson; Michael N G James
Structural study of the complex between human pepsin and a phosphorus-containing peptidic -transition-state analog.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 3):272-9.
2000: Michael A Joyce; Marie E Fraser; Michael N G James; WA Bridger; William T Wolodko
ADP-binding site of Escherichia coli succinyl-CoA synthetase revealed by x-ray crystallography.
Biochemistry 2000;39(1):17-25.
2000: KS Bateman; S Anderson; Wuyuan Lu; MA Qasim; Michael Laskowski; Michael N G James
Deleterious effects of beta-branched residues in the S1 specificity pocket of Streptomyces griseus proteinase B (SGPB): crystal structures of the turkey ovomucoid third domain variants Ile18I, Val18I, Thr18I, and Ser18I in complex with SGPB.
Protein science : a publication of the Protein Society 2000;9(1):83-94.
2000: Jonathan C Parrish; Rudong Shan; Edward E Knaus; Michael N G James
Racemic isopropyl 1,4-dihydro-2,6-dimethyl-4-(6-methyl-2-pyridyl)-3- nitropyridine-5-carboxylate hemibenzene solvate.
Acta crystallographica. Section C, Crystal structure communications 2000;56 ( Pt 1)():107-9.
1999: Ernst M Bergmann; Maia M Cherney; JD McKendrick; S Frormann; C Luo; BA Malcolm; John C Vederas; Michael N G James
Crystal structure of an inhibitor complex of the 3C proteinase from hepatitis A virus (HAV) and implications for the polyprotein processing in HAV.
Virology 1999;265(1):153-63.
1999: Nina K Bernstein; Michael N G James
Novel ways to prevent proteolysis - prophytepsin and proplasmepsin II.
Current opinion in structural biology 1999;9(6):684-9.
1999: JF Petersen; Maia M Cherney; Hans-Dieter Liebig; Tim Skern; Ernst Kuechler; Michael N G James
The structure of the 2A proteinase from a common cold virus: a proteinase responsible for the shut-off of host-cell protein synthesis.
The EMBO journal 1999;18(20):5463-75.
1999: AR Khan; N Khazanovich-Bernstein; Ernst M Bergmann; Michael N G James
Structural aspects of activation pathways of aspartic protease zymogens and viral 3C protease precursors.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(20):10968-75.
1999: A Caputo; Jonathan C Parrish; Michael N G James; James C Powers; R Chris Bleackley
Electrostatic reversal of serine proteinase substrate specificity.
Proteins 1999;35(4):415-24.
1999: Michael A Joyce; Marie E Fraser; Edward R Brownie; Michael N G James; WA Bridger; William T Wolodko
Probing the nucleotide-binding site of Escherichia coli succinyl-CoA synthetase.
Biochemistry 1999;38(22):7273-83.
1999: MA Qasim; Stephen M Lu; J Ding; KS Bateman; Michael N G James; Stephen Anderson; J Song; John Lute Markley; Philip J Ganz; Charles W Saunders; Michael Laskowski
Thermodynamic criterion for the conformation of P1 residues of substrates and of inhibitors in complexes with serine proteinases.
Biochemistry 1999;38(22):7142-50.
1999: D L Bailey; Marie E Fraser; WA Bridger; Michael N G James; William T Wolodko
A dimeric form of Escherichia coli succinyl-CoA synthetase produced by site-directed mutagenesis.
Journal of molecular biology 1999;285(4):1655-66.
1999: Marie E Fraser; Michael N G James; WA Bridger; William T Wolodko
A detailed structural description of Escherichia coli succinyl-CoA synthetase.
Journal of molecular biology 1999;285(4):1633-53.
1999: Nina K Bernstein; Maia M Cherney; Hansruedi Loetscher; RG Ridley; Michael N G James
Crystal structure of the novel aspartic proteinase zymogen proplasmepsin II from plasmodium falciparum.
Nature structural biology 1999;6(1):32-7.
1998: Masao Fujinaga; K Huang; KS Bateman; Michael N G James
Computational analysis of the binding of P1 variants of domain 3 of turkey ovomucoid inhibitor to Streptomyces griseus protease B.
Journal of molecular biology 1998;284(5):1683-94.
1998: AR Khan; Jonathan C Parrish; Marie E Fraser; W W Smith; Paul A Bartlett; Michael N G James
Lowering the entropic barrier for binding conformationally flexible inhibitors to enzymes.
Biochemistry 1998;37(48):16839-45.
1998: Brian L Mark; G A Wasney; Timothy J Salo; A R Khan; Z Cao; P W Robbins; Michael N G James; Barbara L Triggs-Raine
Structural and functional characterization of Streptomyces plicatus beta-N-acetylhexosaminidase by comparative molecular modeling and site-directed mutagenesis.
The Journal of biological chemistry 1998;273(31):19618-24.
1998: AR Khan; Michael N G James
Molecular mechanisms for the conversion of zymogens to active proteolytic enzymes.
Protein science : a publication of the Protein Society 1998;7(4):815-36.
1998: JF Petersen; MM Chernaia; C Rao-Naik; J L Zalatoris; Ben M Dunn; Michael N G James
X-ray crystallographic studies of the complex between porcine pepsin and the aspartic proteinase inhibitor PI-3 from the nematode Ascaris suum.
Advances in experimental medicine and biology 1998;436():391-5.
1998: Marie E Fraser; J H Meyer; Paul A Bartlett; Michael N G James
Overcoming the unfavourable entropic contribution of ligand binding with a macrocyclic inhibitor bound to penicillopepsin.
Advances in experimental medicine and biology 1998;436():355-9.
1998: AR Khan; MM Chernaia; NI Tarasova; Michael N G James
Crystallographic studies of an activation intermediate of human gastricsin.
Advances in experimental medicine and biology 1998;436():265-70.
1998: K S Bateman; MM Chernaia; NI Tarasova; Michael N G James
Crystal structure of human pepsinogen A.
Advances in experimental medicine and biology 1998;436():259-63.
1997: AR Khan; Maia M Cherney; NI Tarasova; Michael N G James
Structural characterization of activation 'intermediate 2' on the pathway to human gastricsin.
Nature structural biology 1997;4(12):1010-5.
1997: Steven C Mosimann; Maia M Cherney; SK Sia; S Plotch; Michael N G James
Refined X-ray crystallographic structure of the poliovirus 3C gene product.
Journal of molecular biology 1997;273(5):1032-47.
1997: Natalie C J Strynadka; Maia M Cherney; A R Sielecki; Monica X Li; Lawrence B Smillie; Michael N G James
Structural details of a calcium-induced molecular switch: X-ray crystallographic analysis of the calcium-saturated N-terminal domain of troponin C at 1.75 A resolution.
Journal of molecular biology 1997;273(1):238-55.
1997: Ernst M Bergmann; Steven C Mosimann; MM Chernaia; BA Malcolm; Michael N G James
The refined crystal structure of the 3C gene product from hepatitis A virus: specific proteinase activity and RNA recognition.
Journal of virology 1997;71(3):2436-48.
1997: MA Qasim; Philip J Ganz; Charles W Saunders; KS Bateman; Michael N G James; Michael Laskowski
Interscaffolding additivity. Association of P1 variants of eglin c and of turkey ovomucoid third domain with serine proteinases.
Biochemistry 1997;36(7):1598-607.
1997: A R Khan; K A Johnson; J Braam; Michael N G James
Comparative modeling of the three-dimensional structure of the calmodulin-related TCH2 protein from Arabidopsis.
Proteins 1997;27(1):144-53.
1996: M Fujinaga; MM Chernaia; R Halenbeck; K Koths; Michael N G James
The crystal structure of PR3, a neutrophil serine proteinase antigen of Wegener's granulomatosis antibodies.
Journal of molecular biology 1996;261(2):267-78.
1996: S C Mosimann; D L Newton; R J Youle; Michael N G James
X-ray crystallographic structure of recombinant eosinophil-derived neurotoxin at 1.83 A resolution.
Journal of molecular biology 1996;260(4):540-52.
1996: N C Strynadka; Susan E Jensen; Pedro Alzari; Michael N G James
A potent new mode of beta-lactamase inhibition revealed by the 1.7 A X-ray crystallographic structure of the TEM-1-BLIP complex.
Nature structural biology 1996;3(3):290-7.
1996: N C Strynadka; Miriam Eisenstein; Ephraim Katchalski-Katzir; Brian Shoichet; Irwin D Kuntz; Ruben Abagyan; Maxim Totrov; J Janin; Jacqueline Cherfils; F Zimmerman; A Olson; B Duncan; M Rao; R Jackson; M Sternberg; Michael N G James
Molecular docking programs successfully predict the binding of a beta-lactamase inhibitory protein to TEM-1 beta-lactamase.
Nature structural biology 1996;3(3):233-9.
1996: N C Strynadka; Michael N G James
Lysozyme: a model enzyme in protein crystallography.
EXS 1996;75():185-222.
1995: S Mosimann; R Meleshko; Michael N G James
A critical assessment of comparative molecular modeling of tertiary structures of proteins.
Proteins 1995;23(3):301-17.
1995: K Huang; Wuyuan Lu; S Anderson; Michael Laskowski; Michael N G James
Water molecules participate in proteinase-inhibitor interactions: crystal structures of Leu18, Ala18, and Gly18 variants of turkey ovomucoid inhibitor third domain complexed with Streptomyces griseus proteinase B.
Protein science : a publication of the Protein Society 1995;4(10):1985-97.
1995: S A Moore; Michael N G James
Structural refinement of the non-fluorescent flavoprotein from Photobacterium leiognathi at 1.60 A resolution.
Journal of molecular biology 1995;249(1):195-214.
1995: M Fujinaga; MM Chernaia; NI Tarasova; S C Mosimann; Michael N G James
Crystal structure of human pepsin and its complex with pepstatin.
Protein science : a publication of the Protein Society 1995;4(5):960-72.
1995: S A Moore; A R Sielecki; MM Chernaia; NI Tarasova; Michael N G James
Crystal and molecular structures of human progastricsin at 1.62 A resolution.
Journal of molecular biology 1995;247(3):466-85.
1994: S A Moore; Michael N G James
Common structural features of the luxF protein and the subunits of bacterial luciferase: evidence for a (beta alpha)8 fold in luciferase.
Protein science : a publication of the Protein Society 1994;3(11):1914-26.
1994: H Blanchard; Michael N G James
A crystallographic re-investigation into the structure of Streptomyces griseus proteinase A reveals an acyl-enzyme intermediate.
Journal of molecular biology 1994;241(4):574-87.
1994: K Huang; N C Strynadka; V D Bernard; R J Peanasky; Michael N G James
The molecular structure of the complex of Ascaris chymotrypsin/elastase inhibitor with porcine elastase.
Structure (London, England : 1993) 1994;2(7):679-89.
1994: A Caputo; Michael N G James; James C Powers; Dorothy Hudig; R Chris Bleackley
Conversion of the substrate specificity of mouse proteinase granzyme B.
Nature structural biology 1994;1(6):364-7.
1994: M Allaire; MM Chernaia; BA Malcolm; Michael N G James
Picornaviral 3C cysteine proteinases have a fold similar to chymotrypsin-like serine proteinases.
Nature 1994;369(6475):72-6.
1994: N C Strynadka; Susan E Jensen; K Johns; H Blanchard; M Page; A Matagne; J M Frère; Michael N G James
Structural and kinetic characterization of a beta-lactamase-inhibitor protein.
Nature 1994;368(6472):657-60.
1994: William T Wolodko; Marie E Fraser; Michael N G James; WA Bridger
The crystal structure of succinyl-CoA synthetase from Escherichia coli at 2.5-A resolution.
The Journal of biological chemistry 1994;269(14):10883-90.
1994: S C Mosimann; Wojciech Ardelt; Michael N G James
Refined 1.7 A X-ray crystallographic structure of P-30 protein, an amphibian ribonuclease with anti-tumor activity.
Journal of molecular biology 1994;236(4):1141-53.
1994: C A McPhalen; A R Sielecki; Bernard D Santarsiero; Michael N G James
Refined crystal structure of rat parvalbumin, a mammalian alpha-lineage parvalbumin, at 2.0 A resolution.
Journal of molecular biology 1994;235(2):718-32.
1994: Marie E Fraser; MM Chernaia; Y V Kozlov; Michael N G James
Crystal structure of the holotoxin from Shigella dysenteriae at 2.5 A resolution.
Nature structural biology 1994;1(1):59-64.
1993: MM Chernaia; BA Malcolm; M Allaire; Michael N G James
Hepatitis A virus 3C proteinase: some properties, crystallization and preliminary crystallographic characterization.
Journal of molecular biology 1993;234(3):890-3.
1993: Y V Kozlov; MM Chernaia; Marie E Fraser; Michael N G James
Purification and crystallization of Shiga toxin from Shigella dysenteriae.
Journal of molecular biology 1993;232(2):704-6.
1993: S A Moore; Michael N G James; D J O'Kane; J Lee
Crystal structure of a flavoprotein related to the subunits of bacterial luciferase.
The EMBO journal 1993;12(5):1767-74.
1992: S C Mosimann; K L Johns; Wojciech Ardelt; Stanislaw M Mikulski; Kuslima Shogen; Michael N G James
Comparative molecular modeling and crystallization of P-30 protein: a novel antitumor protein of Rana pipiens oocytes and early embryos.
Proteins 1992;14(3):392-400.
1992: N C Strynadka; H Adachi; Susan E Jensen; K Johns; A Sielecki; C Betzel; K Sutoh; Michael N G James
Molecular structure of the acyl-enzyme intermediate in beta-lactam hydrolysis at 1.7 A resolution.
Nature 1992;359(6397):700-5.
1992: W B Church; L Swenson; Michael N G James; D Mahuran
Crystallization of human beta-hexosaminidase B.
Journal of molecular biology 1992;227(2):577-80.
1992: Marie E Fraser; N C Strynadka; Paul A Bartlett; J E Hanson; Michael N G James
Crystallographic analysis of transition-state mimics bound to penicillopepsin: phosphorus-containing peptide analogues.
Biochemistry 1992;31(22):5201-14.
1992: Michael N G James; A R Sielecki; K Hayakawa; M H Gelb
Crystallographic analysis of transition state mimics bound to penicillopepsin: difluorostatine- and difluorostatone-containing peptides.
Biochemistry 1992;31(15):3872-86.
1992: K Huang; R Kodandapani; Helmut Kallwass; J K Hogan; W Parris; J D Friesen; M Gold; J Bryan Jones; Michael N G James
Crystallization and preliminary X-ray diffraction studies of two mutants of lactate dehydrogenase from Bacillus stearothermophilus.
Proteins 1992;13(2):158-61.
1992: S A Moore; Michael N G James; D J O'Kane; J Lee
Crystallization of Photobacterium leiognathi non-fluorescent flavoprotein, an unusual flavoprotein with limited sequence identity to bacterial luciferase.
Journal of molecular biology 1992;224(2):523-6.
1991: N C Strynadka; Michael N G James
Lysozyme revisited: crystallographic evidence for distortion of an N-acetylmuramic acid residue bound in site D.
Journal of molecular biology 1991;220(2):401-24.
1991: A R Sielecki; M Fujinaga; Randy J Read; Michael N G James
Refined structure of porcine pepsinogen at 1.8 A resolution.
Journal of molecular biology 1991;219(4):671-92.
1991: NS Andreeva; Michael N G James
Why does pepsin have a negative charge at very low pH? An analysis of conserved charged residues in aspartic proteinases.
Advances in experimental medicine and biology 1991;306():39-45.
1991: C A McPhalen; N C Strynadka; Michael N G James
Calcium-binding sites in proteins: a structural perspective.
Advances in protein chemistry 1991;42():77-144.
1990: A R Sielecki; Alexander A Fedorov; A Boodhoo; NS Andreeva; Michael N G James
Molecular and crystal structures of monoclinic porcine pepsin refined at 1.8 A resolution.
Journal of molecular biology 1990;214(1):143-70.
1990: N C Strynadka; Michael N G James
Model for the interaction of amphiphilic helices with troponin C and calmodulin.
Proteins 1990;7(3):234-48.
1989: A R Sielecki; K Hayakawa; M Fujinaga; M E Murphy; M Fraser; A K Muir; C T Carilli; J A Lewicki; J D Baxter; Michael N G James
Structure of recombinant human renin, a target for cardiovascular-active drugs, at 2.5 A resolution.
Science (New York, N.Y.) 1989;243(4896):1346-51.
1989: H M Greenblatt; C A Ryan; Michael N G James
Structure of the complex of Streptomyces griseus proteinase B and polypeptide chymotrypsin inhibitor-1 from Russet Burbank potato tubers at 2.1 A resolution.
Journal of molecular biology 1989;205(1):201-28.
1989: N C Strynadka; Michael N G James
Crystal structures of the helix-loop-helix calcium-binding proteins.
Annual review of biochemistry 1989;58():951-98.
1988: Osnat Herzberg; Michael N G James
Refined crystal structure of troponin C from turkey skeletal muscle at 2.0 A resolution.
Journal of molecular biology 1988;203(3):761-79.
1988: C A McPhalen; Michael N G James
Structural comparison of two serine proteinase-protein inhibitor complexes: eglin-c-subtilisin Carlsberg and CI-2-subtilisin Novo.
Biochemistry 1988;27(17):6582-98.
1988: Randy J Read; Michael N G James
Refined crystal structure of Streptomyces griseus trypsin at 1.7 A resolution.
Journal of molecular biology 1988;200(3):523-51.
1988: N C Strynadka; Michael N G James
Two trifluoperazine-binding sites on calmodulin predicted from comparative molecular modeling with troponin-C.
Proteins 1988;3(1):1-17.
1988: M E Murphy; John Moult; R Chris Bleackley; H Gershenfeld; I L Weissman; Michael N G James
Comparative molecular model building of two serine proteinases from cytotoxic T lymphocytes.
Proteins 1988;4(3):190-204.
1987: G M Clore; A M Gronenborn; Michael N G James; M Kjaer; C A McPhalen; F M Poulsen
Comparison of the solution and X-ray structures of barley serine proteinase inhibitor 2.
Protein engineering 1987;1(4):313-8.
1987: M Fujinaga; A R Sielecki; Randy J Read; Wojciech Ardelt; Michael Laskowski; Michael N G James
Crystal and molecular structures of the complex of alpha-chymotrypsin with its inhibitor turkey ovomucoid third domain at 1.8 A resolution.
Journal of molecular biology 1987;195(2):397-418.
1987: M Fujinaga; Michael N G James
Rat submaxillary gland serine protease, tonin. Structure solution and refinement at 1.8 A resolution.
Journal of molecular biology 1987;195(2):373-96.
1987: C A McPhalen; Michael N G James
Crystal and molecular structure of the serine proteinase inhibitor CI-2 from barley seeds.
Biochemistry 1987;26(1):261-9.
1986: S P Williams; WA Bridger; Michael N G James
Characterization of the phosphoserine of pepsinogen using 31P nuclear magnetic resonance: corroboration of X-ray crystallographic results.
Biochemistry 1986;25(21):6655-9.
1986: John Moult; Michael N G James
An algorithm for determining the conformation of polypeptide segments in proteins by systematic search.
Proteins 1986;1(2):146-63.
1985: C A McPhalen; I Svendsen; I Jonassen; Michael N G James
Crystal and molecular structure of chymotrypsin inhibitor 2 from barley seeds in complex with subtilisin Novo.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(21):7242-6.
1985: C A McPhalen; H P Schnebli; Michael N G James
Crystal and molecular structure of the inhibitor eglin from leeches in complex with subtilisin Carlsberg.
FEBS letters 1985;188(1):55-8.
1984: William T Wolodko; Michael N G James; WA Bridger
Crystallization of succinyl-CoA synthetase from Escherichia coli.
The Journal of biological chemistry 1984;259(8):5316-20.
1983: Randy J Read; M Fujinaga; A R Sielecki; Michael N G James
Structure of the complex of Streptomyces griseus protease B and the third domain of the turkey ovomucoid inhibitor at 1.8-A resolution.
Biochemistry 1983;22(19):4420-33.
1983: C A McPhalen; C Evans; K Hayakawa; I Jonassen; I Svendsen; Michael N G James
Preliminary crystallographic data for the serine protease inhibitor CI-2 from barley seeds.
Journal of molecular biology 1983;168(2):445-7.
1982: M Fujinaga; Randy J Read; A Sielecki; Wojciech Ardelt; Michael Laskowski; Michael N G James
Refined crystal structure of the molecular complex of Streptomyces griseus protease B, a serine protease, with the third domain of the ovomucoid inhibitor from turkey.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(16):4868-72.