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Michael James

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Concepts & Ideas

Procedures

X-Ray Crystallography

Chemicals & Drugs

Genes & Molecular Sequences

Amino Acid Sequence

Phenomena

Living Beings

Mycobacterium tuberculosis

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Network (preview)

Co-Publications
Name
58
Cherney, Maia
21
Garen, Craig
17
Vederas, John
14
Fraser, Marie
11
Chernaia, MM
10
Cherney, Leonid
10
Laskowski, Michael
9
Bridger, WA
9
Ng, Kenneth K-S
9
Yin, Jiang
8
Wolodko, William
8
Eltis, Lindsay
7
Biswal, Bichitra
7
Qasim, MA
7
Mark, Brian

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Publications

TOP 3
James Michael N G; Yin Jiang
Regulatory RNA elements.
Zhang Yanfei; Cherney Maia M; Solomonson Matthew; Liu Jianshe; James Michael N G; Weiner Joel H
Preliminary X-ray crystallographic analysis of sulfide:quinone oxidoreductase from Acidithiobacillus ferrooxidans.
Cherney Leonid T; Cherney Maia M; Garen Craig R; James Michael N G
The structure of the arginine repressor from Mycobacterium tuberculosis bound with its DNA operator and Co-repressor, L-arginine.

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All Publications

2009: James Michael N G; Yin Jiang
Regulatory RNA elements.
Biochimica et biophysica acta 2009;1789(9-10):493-4.
2009: Zhang Yanfei; Cherney Maia M; Solomonson Matthew; Liu Jianshe; James Michael N G; Weiner Joel H
Preliminary X-ray crystallographic analysis of sulfide:quinone oxidoreductase from Acidithiobacillus ferrooxidans.
Acta crystallographica. Section F, Structural biology and crystallization communications 2009;65(Pt 8):839-42.
2009: Cherney Leonid T; Cherney Maia M; Garen Craig R; James Michael N G
The structure of the arginine repressor from Mycobacterium tuberculosis bound with its DNA operator and Co-repressor, L-arginine.
Journal of molecular biology 2009;388(1):85-97.
2009: Pillai Bindu; Moorthie Vijayalakshmi A; van Belkum Marco J; Marcus Sandra L; Cherney Maia M; Diaper Christopher M; Vederas John C; James Michael N G
Crystal structure of diaminopimelate epimerase from Arabidopsis thaliana, an amino acid racemase critical for L-lysine biosynthesis.
Journal of molecular biology 2009;385(2):580-94.
2008: Cherney Leonid T; Cherney Maia M; Garen Craig R; Lu George J; James Michael N G
Crystal structure of the arginine repressor protein in complex with the DNA operator from Mycobacterium tuberculosis.
Journal of molecular biology 2008;384(5):1330-40.
2008: Watanabe Nobuhiko; Clay Matthew D; van Belkum Marco J; Cherney Maia M; Vederas John C; James Michael N G
Mechanism of substrate recognition and PLP-induced conformational changes in LL-diaminopimelate aminotransferase from Arabidopsis thaliana.
Journal of molecular biology 2008;384(5):1314-29.
2008: Cherney Maia M; Garen Craig R; James Michael N G
Crystal structure of Mycobacterium tuberculosis Rv0760c at 1.50 A resolution, a structural homolog of Delta(5)-3-ketosteroid isomerase.
Biochimica et biophysica acta 2008;1784(11):1625-32.
2008: Li Zhenqiang; Kienetz Martin; Cherney Maia M; James Michael N G; Brömme Dieter
The crystal and molecular structures of a cathepsin K:chondroitin sulfate complex.
Journal of molecular biology 2008;383(1):78-91.
2008: Zhang Jianmin; Huitema Carly; Niu Chunying; Yin Jiang; James Michael N G; Eltis Lindsay D; Vederas John C
Aryl methylene ketones and fluorinated methylene ketones as reversible inhibitors for severe acute respiratory syndrome (SARS) 3C-like proteinase.
Bioorganic chemistry 2008;36(5):229-40.
2008: Yin Jiang; Garen Craig R; Cherney Maia M; Cherney Leonid T; James Michael N G
Expression, purification and preliminary crystallographic analysis of N-acetylglucosamine-1-phosphate uridylyltransferase from Mycobacterium tuberculosis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2008;64(Pt 9):805-8.
2008: Cherney Leonid T; Cherney Maia M; Garen Craig R; Lu George J; James Michael N G
Structure of the C-terminal domain of the arginine repressor protein from Mycobacterium tuberculosis.
Acta crystallographica. Section D, Biological crystallography 2008;64(Pt 9):950-6.
2008: Biswal Bichitra K; Morisseau Christophe; Garen Grace; Cherney Maia M; Garen Craig; Niu Chunying; Hammock Bruce D; James Michael N G
The molecular structure of epoxide hydrolase B from Mycobacterium tuberculosis and its complex with a urea-based inhibitor.
Journal of molecular biology 2008;381(4):897-912.
2008: Witholt Sarah J; Sankaranarayanan Ramasamy; Garen Craig R; Cherney Maia M; Cherney Leonid T; James Michael N G
Expression, purification, crystallization and preliminary X-ray analysis of Rv3117, a probable thiosulfate sulfurtransferase (CysA3) from Mycobacterium tuberculosis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2008;64(Pt 6):541-4.
2008: Huitema Carly; Zhang Jianmin; Yin Jiang; James Michael N G; Vederas John C; Eltis Lindsay D
Heteroaromatic ester inhibitors of hepatitis A virus 3C proteinase: Evaluation of mode of action.
Bioorganic & medicinal chemistry 2008;16(10):5761-77.
2008: Lee Ting-Wai; James Michael N G
1.2A-resolution crystal structures reveal the second tetrahedral intermediates of streptogrisin B (SGPB).
Biochimica et biophysica acta 2008;1784(2):319-34.
2008: Mazumdar Pooja A; Hulecki Jordan C; Cherney Maia M; Garen Craig R; James Michael N G
X-ray crystal structure of Mycobacterium tuberculosis haloalkane dehalogenase Rv2579.
Biochimica et biophysica acta 2008;1784(2):351-62.
2008: Sankaranarayanan Ramasamy; Cherney Maia M; Cherney Leonid T; Garen Craig R; Moradian Fatemeh; James Michael N G
The crystal structures of ornithine carbamoyltransferase from Mycobacterium tuberculosis and its ternary complex with carbamoyl phosphate and L-norvaline reveal the enzyme's catalytic mechanism.
Journal of molecular biology 2008;375(4):1052-63.
2008: Niu Chunying; Yin Jiang; Zhang Jianmin; Vederas John C; James Michael N G
Molecular docking identifies the binding of 3-chloropyridine moieties specifically to the S1 pocket of SARS-CoV Mpro.
Bioorganic & medicinal chemistry 2008;16(1):293-302.
2008: Polymenidou Magdalini; Moos Rita; Scott Mike; Sigurdson Christina; Shi Yong-Zhong; Yajima Bill; Hafner-Bratkovic Iva; Jerala Roman; Hornemann Simone; Wuthrich Kurt; Bellon Anne; Vey Martin; Garen Graciela; James Michael N G; Kav Nat; Aguzzi Adriano
The POM monoclonals: a comprehensive set of antibodies to non-overlapping prion protein epitopes.
PloS one 2008;3(12):e3872.
2007: Lu George J; Garen Craig R; Cherney Maia M; Cherney Leonid T; Lee Cecilia; James Michael N G
Expression, purification and preliminary X-ray analysis of the C-terminal domain of an arginine repressor protein from Mycobacterium tuberculosis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 11):936-9.
2007: Pillai Bindu; Cherney Maia; Diaper Christopher M; Sutherland Andrew; Blanchard John S; Vederas John C; James Michael N G
Dynamics of catalysis revealed from the crystal structures of mutants of diaminopimelate epimerase.
Biochemical and biophysical research communications 2007;363(3):547-53.
2007: Yin Jiang; Niu Chunying; Cherney Maia M; Zhang Jianmin; Huitema Carly; Eltis Lindsay D; Vederas John C; James Michael N G
A mechanistic view of enzyme inhibition and peptide hydrolysis in the active site of the SARS-CoV 3C-like peptidase.
Journal of molecular biology 2007;371(4):1060-74.
2007: Watanabe Nobuhiko; Cherney Maia M; van Belkum Marco J; Marcus Sandra L; Flegel Mitchel D; Clay Matthew D; Deyholos Michael K; Vederas John C; James Michael N G
Crystal structure of LL-diaminopimelate aminotransferase from Arabidopsis thaliana: a recently discovered enzyme in the biosynthesis of L-lysine by plants and Chlamydia.
Journal of molecular biology 2007;371(3):685-702.
2007: Murillo A C; Li H Y; Alber T; Baker E N; Berger J M; Cherney L T; Cherney M M; Cho Yoon Song; Eisenberg D; Garen C R; Goulding C W; Hung L W; Ioerger T R; Jacobs W R; James M N G; Kim C; Krieger I; Lott J S; Sankaranarayanan R; Segelke B W; Terwilliger T C; Wang F; Wang S; Sacchettini J C
High throughput crystallography of TB drug targets.
Infectious disorders drug targets 2007;7(2):127-39.
2007: Zhang Jianmin; Pettersson Hanna I; Huitema Carly; Niu Chunying; Yin Jiang; James Michael N G; Eltis Lindsay D; Vederas John C
Design, synthesis, and evaluation of inhibitors for severe acute respiratory syndrome 3C-like protease based on phthalhydrazide ketones or heteroaromatic esters.
Journal of medicinal chemistry 2007;50(8):1850-64.
2007: Cherney Leonid T; Cherney Maia M; Garen Craig R; Niu Chunying; Moradian Fatemeh; James Michael N G
Crystal structure of N-acetyl-gamma-glutamyl-phosphate reductase from Mycobacterium tuberculosis in complex with NADP(+).
Journal of molecular biology 2007;367(5):1357-69.
2007: Weidauer Enrico; Yasuda Yoshiyuki; Biswal Bichitra K; Cherny Maia; James Michael N G; Brömme Dieter
Effects of disease-modifying anti-rheumatic drugs (DMARDs) on the activities of rheumatoid arthritis-associated cathepsins K and S.
Biological chemistry 2007;388(3):331-6.
2007: Lee Ting-Wai; Qasim M A; Laskowski Michael; James Michael N G
Structural insights into the non-additivity effects in the sequence-to-reactivity algorithm for serine peptidases and their inhibitors.
Journal of molecular biology 2007;367(2):527-46.
2007: Lee Ting-Wai; Cherney Maia M; Liu Jie; James Karen Ellis; Powers James C; Eltis Lindsay D; James Michael N G
Crystal structures reveal an induced-fit binding of a substrate-like Aza-peptide epoxide to SARS coronavirus main peptidase.
Journal of molecular biology 2007;366(3):916-32.
2007: Lemieux M Joanne; Fischer Sarah J; Cherney Maia M; Bateman Katherine S; James Michael N G
The crystal structure of the rhomboid peptidase from Haemophilus influenzae provides insight into intramembrane proteolysis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(3):750-4.
2007: Pillai B; Cherney Maia M; Hiraga Kazumi; Takada Katsumi; Oda Kohei; James Michael N G
Crystal structure of scytalidoglutamic peptidase with its first potent inhibitor provides insights into substrate specificity and catalysis.
Journal of molecular biology 2007;365(2):343-61.
2006: Garen Craig R; Cherney Maia M; Bergmann Ernst M; James Michael N G
The molecular structure of Rv1873, a conserved hypothetical protein from Mycobacterium tuberculosis, at 1.38 A resolution.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 12):1201-5.
2006: Moradian Fatemeh; Garen Craig; Cherney Leonid; Cherney Maia; James Michael N G
Expression, purification, crystallization and preliminary X-ray analysis of two arginine-biosynthetic enzymes from Mycobacterium tuberculosis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 10):986-8.
2006: James Michael N G
The peptidases from fungi and viruses.
Biological chemistry 2006;387(8):1023-9.
2006: Biswal Bichitra K; Au Karolyn; Cherney Maia M; Garen Craig; James Michael N G
The molecular structure of Rv2074, a probable pyridoxine 5'-phosphate oxidase from Mycobacterium tuberculosis, at 1.6 angstroms resolution.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 8):735-42.
2006: Yin Jiang; Cherney Maia M; Bergmann Ernst M; Zhang Jianmin; Huitema Carly; Pettersson Hanna; Eltis Lindsay D; Vederas John C; James Michael N G
An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors.
Journal of molecular biology 2006;361(4):673-86.
2006: Biswal Bichitra K; Wang Meitian; Cherney Maia M; Chan Laval; Yannopoulos Constantin G; Bilimoria Darius; Bedard Jean; James Michael N G
Non-nucleoside inhibitors binding to hepatitis C virus NS5B polymerase reveal a novel mechanism of inhibition.
Journal of molecular biology 2006;361(1):33-45.
2006: Fraser Marie E; Cherney Maia M; Marcato Paola; Mulvey George L; Armstrong Glen D; James Michael N G
Binding of adenine to Stx2, the protein toxin from Escherichia coli O157:H7.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 7):627-30.
2006: Pillai Bindu; Cherney Maia M; Diaper Christopher M; Sutherland Andrew; Blanchard John S; Vederas John C; James Michael N G
Structural insights into stereochemical inversion by diaminopimelate epimerase: an antibacterial drug target.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(23):8668-73.
2006: Lemieux M Joanne; Mark Brian L; Cherney Maia M; Withers Stephen G; Mahuran Don J; James Michael N G
Crystallographic structure of human beta-hexosaminidase A: interpretation of Tay-Sachs mutations and loss of GM2 ganglioside hydrolysis.
Journal of molecular biology 2006;359(4):913-29.
2006: Yin Jiang; Xu Linda X; Cherney Maia M; Raux-Deery Evelyne; Bindley Amanda A; Savchenko Alexei; Walker John R; Cuff Marianne E; Warren Martin J; James Michael N G
Crystal structure of the vitamin B12 biosynthetic cobaltochelatase, CbiXS, from Archaeoglobus fulgidus.
Journal of structural and functional genomics 2006;7(1):37-50.
2006: Biswal Bichitra K; Garen Grace; Cherney Maia M; Garen Craig; James Michael N G
Cloning, expression, purification, crystallization and preliminary X-ray studies of epoxide hydrolases A and B from Mycobacterium tuberculosis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 2):136-8.
2006: Maynes Jason T; Luu Hue A; Cherney Maia M; Andersen Raymond J; Williams David; Holmes Charles F B; James Michael N G
Crystal structures of protein phosphatase-1 bound to motuporin and dihydromicrocystin-LA: elucidation of the mechanism of enzyme inhibition by cyanobacterial toxins.
Journal of molecular biology 2006;356(1):111-20.
2005: Lemieux M Joanne; Ference Claire; Cherney Maia M; Wang Metian; Garen Craig; James Michael N G
The crystal structure of Rv0793, a hypothetical monooxygenase from M. tuberculosis.
Journal of structural and functional genomics 2005;6(4):245-57.
2005: Diaper Christopher M; Sutherland Andrew; Pillai Bindu; James Michael N G; Semchuk Paul; Blanchard John S; Vederas John C
The stereoselective synthesis of aziridine analogues of diaminopimelic acid (DAP) and their interaction with dap epimerase.
Organic & biomolecular chemistry 2005;3(24):4402-11.
2005: Yin Jiang; Bergmann Ernst M; Cherney Maia M; Lall Manjinder S; Jain Rajendra P; Vederas John C; James Michael N G
Dual modes of modification of hepatitis A virus 3C protease by a serine-derived beta-lactone: selective crystallization and formation of a functional catalytic triad in the active site.
Journal of molecular biology 2005;354(4):854-71.
2005: Biswal Bichitra K; Cherney Maia M; Wang Meitian; Garen Craig; James Michael N G
Structures of Mycobacterium tuberculosispyridoxine 5'-phosphate oxidase and its complexes with flavin mononucleotide and pyridoxal 5'-phosphate.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 11):1492-9.
2005: Lee Ting-Wai; Cherney Maia M; Huitema Carly; Liu Jie; James Karen Ellis; Powers James C; Eltis Lindsay D; James Michael N G
Crystal structures of the main peptidase from the SARS coronavirus inhibited by a substrate-like aza-peptide epoxide.
Journal of molecular biology 2005;353(5):1137-51.
2005: Kataoka Yukiko; Takada Katsumi; Oyama Hiroshi; Tsunemi Masahiko; James Michael N G; Oda Kohei
Catalytic residues and substrate specificity of scytalidoglutamic peptidase, the first member of the eqolisin in family (G1) of peptidases.
FEBS letters 2005;579(14):2991-4.
2005: Maynes Jason T; Cherney Maia M; Qasim M A; Laskowski Michael; James Michael N G
Structure of the subtilisin Carlsberg-OMTKY3 complex reveals two different ovomucoid conformations.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 5):580-8.
2005: Biswal Bichitra K; Cherney Maia M; Wang Meitian; Chan Laval; Yannopoulos Constantin G; Bilimoria Darius; Nicolas Olivier; Bedard Jean; James Michael N G
Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors.
The Journal of biological chemistry 2005;280(18):18202-10.
2004: Jain Rajendra P; Pettersson Hanna I; Zhang Jianmin; Aull Katherine D; Fortin Pascal D; Huitema Carly; Eltis Lindsay D; Parrish Jonathan C; James Michael N G; Wishart David S; Vederas John C
Synthesis and evaluation of keto-glutamine analogues as potent inhibitors of severe acute respiratory syndrome 3CLpro.
Journal of medicinal chemistry 2004;47(25):6113-6.
2004: Maynes Jason T; Perreault Kathleen R; Cherney Maia M; Luu Hue Anh; James Michael N G; Holmes Charles F B
Crystal structure and mutagenesis of a protein phosphatase-1:calcineurin hybrid elucidate the role of the beta12-beta13 loop in inhibitor binding.
The Journal of biological chemistry 2004;279(41):43198-206.
2004: Fraser Marie E; Fujinaga Masao; Cherney Maia M; Melton-Celsa Angela R; Twiddy Edda M; O'Brien Alison D; James Michael N G
Structure of shiga toxin type 2 (Stx2) from Escherichia coli O157:H7.
The Journal of biological chemistry 2004;279(26):27511-7.
2004: Fujinaga Masao; Cherney Maia M; Oyama Hiroshi; Oda Kohei; James Michael N G
The molecular structure and catalytic mechanism of a novel carboxyl peptidase from Scytalidium lignicolum.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(10):3364-9.
2003: Maynes Jason T; Garen Craig; Cherney Maia M; Newton Gerald; Arad Dorit; Av-Gay Yossef; Fahey Robert C; James Michael N G
The crystal structure of 1-D-myo-inosityl 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) from Mycobacterium tuberculosis reveals a zinc hydrolase with a lactate dehydrogenase fold.
The Journal of biological chemistry 2003;278(47):47166-70.
2003: Barrette-Ng Isabelle H; Ng Kenneth K-S; Cherney Maia M; Pearce Gregory; Ghani Usman; Ryan Clarence A; James Michael N G
Unbound form of tomato inhibitor-II reveals interdomain flexibility and conformational variability in the reactive site loops.
The Journal of biological chemistry 2003;278(33):31391-400.
2003: Bernstein Nina Khazanovich; Cherney Maia M; Yowell Charles A; Dame John B; James Michael N G
Structural insights into the activation of P. vivax plasmepsin.
Journal of molecular biology 2003;329(3):505-24.
2003: Barrette-Ng Isabelle H; Ng Kenneth K-S; Cherney Maia M; Pearce Gregory; Ryan Clarence A; James Michael N G
Structural basis of inhibition revealed by a 1:2 complex of the two-headed tomato inhibitor-II and subtilisin Carlsberg.
The Journal of biological chemistry 2003;278(26):24062-71.
2003: Mark Brian L; Mahuran Don J; Cherney Maia M; Zhao Dalian; Knapp Spencer; James Michael N G
Crystal structure of human beta-hexosaminidase B: understanding the molecular basis of Sandhoff and Tay-Sachs disease.
Journal of molecular biology 2003;327(5):1093-109.
2003: Wang Meitian; Ng Kenneth K-S; Cherney Maia M; Chan Laval; Yannopoulos Constantin G; Bedard Jean; Morin Nicolas; Nguyen-Ba Nghe; Alaoui-Ismaili Moulay H; Bethell Richard C; James Michael N G
Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibition.
The Journal of biological chemistry 2003;278(11):9489-95.
2002: Toyota Eiko; Ng Kenneth K S; Kuninaga Shiro; Sekizaki Haruo; Itoh Kunihiko; Tanizawa Kazutaka; James Michael N G
Crystal structure and nucleotide sequence of an anionic trypsin from chum salmon (Oncorhynchus keta) in comparison with Atlantic salmon (Salmo salar) and bovine trypsin.
Journal of molecular biology 2002;324(3):391-7.
2002: Holmes C F B; Maynes J T; Perreault K R; Dawson J F; James M N G
Molecular enzymology underlying regulation of protein phosphatase-1 by natural toxins.
Current medicinal chemistry 2002;9(22):1981-9.
2002: Williams Spencer J; Mark Brian L; Vocadlo David J; James Michael N G; Withers Stephen G
Aspartate 313 in the Streptomyces plicatus hexosaminidase plays a critical role in substrate-assisted catalysis by orienting the 2-acetamido group and stabilizing the transition state.
The Journal of biological chemistry 2002;277(42):40055-65.
2002: Barrette-Ng Isabelle H; Ng Kenneth K-S; Mark Brian L; Van Aken Danny; Cherney Maia M; Garen Craig; Kolodenko Yuliya; Gorbalenya Alexander E; Snijder Eric J; James Michael N G
Structure of arterivirus nsp4. The smallest chymotrypsin-like proteinase with an alpha/beta C-terminal extension and alternate conformations of the oxyanion hole.
The Journal of biological chemistry 2002;277(42):39960-6.
2002: Ramtohul Yeeman K; James Michael N G; Vederas John C
Synthesis and evaluation of keto-glutamine analogues as inhibitors of hepatitis A virus 3C proteinase.
The Journal of organic chemistry 2002;67(10):3169-78.
2002: Lall Manjinder S; Ramtohul Yeeman K; James Michael N G; Vederas John C
Serine and threonine beta-lactones: a new class of hepatitis A virus 3C cysteine proteinase inhibitors.
The Journal of organic chemistry 2002;67(5):1536-47.
2002: Ng Kenneth K S; Cherney Maia M; Vazquez Ana Lopez; Machin Angeles; Alonso Jose M Martin; Parra Francisco; James Michael N G
Crystal structures of active and inactive conformations of a caliciviral RNA-dependent RNA polymerase.
The Journal of biological chemistry 2002;277(2):1381-7.
2001: Ghani U; Ng K K; Atta-ur-Rahman; Choudhary M I; Ullah N; James M N
Crystal structure of gamma-chymotrypsin in complex with 7-hydroxycoumarin.
Journal of molecular biology 2001;314(3):519-25.
2001: Maynes J T; Bateman K S; Cherney M M; Das A K; Luu H A; Holmes C F; James M N
Crystal structure of the tumor-promoter okadaic acid bound to protein phosphatase-1.
The Journal of biological chemistry 2001;276(47):44078-82.
2001: Mark B L; Vocadlo D J; Zhao D; Knapp S; Withers S G; James M N
Biochemical and structural assessment of the 1-N-azasugar GalNAc-isofagomine as a potent family 20 beta-N-acetylhexosaminidase inhibitor.
The Journal of biological chemistry 2001;276(45):42131-7.
2001: Mark B L; Parrish J C; Wang Z X; Wiebe L I; Knaus E E; James M N
(E)-1-(2'-deoxy-beta-D-ribofuranosyl)-2,4-difluoro-5-(2-iodovinyl)benzene.
Acta crystallographica. Section C, Crystal structure communications 2001;57(Pt 6):758-60.
2001: Mark B L; Vocadlo D J; Knapp S; Triggs-Raine B L; Withers S G; James M N
Crystallographic evidence for substrate-assisted catalysis in a bacterial beta-hexosaminidase.
The Journal of biological chemistry 2001;276(13):10330-7.
2001: Lu S M; Lu W; Qasim M A; Anderson S; Apostol I; Ardelt W; Bigler T; Chiang Y W; Cook J; James M N; Kato I; Kelly C; Kohr W; Komiyama T; Lin T Y; Ogawa M; Otlewski J; Park S J; Qasim S; Ranjbar M; Tashiro M; Warne N; Whatley H; Wieczorek A; Wieczorek M; Wilusz T; Wynn R; Zhang W; Laskowski M
Predicting the reactivity of proteins from their sequence alone: Kazal family of protein inhibitors of serine proteinases.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1410-5.
2001: Bateman K S; Huang K; Anderson S; Lu W; Qasim M A; Laskowski M; James M N
Contribution of peptide bonds to inhibitor-protease binding: crystal structures of the turkey ovomucoid third domain backbone variants OMTKY3-Pro18I and OMTKY3-psi[COO]-Leu18I in complex with Streptomyces griseus proteinase B (SGPB) and the structure of the free inhibitor, OMTKY-3-psi[CH2NH2+]-Asp19I.
Journal of molecular biology 2001;305(4):839-49.
2001: Toyota E; Ng K K; Sekizaki H; Itoh K; Tanizawa K; James M N
X-ray crystallographic analyses of complexes between bovine beta-trypsin and Schiff base copper(II) or iron(III) chelates.
Journal of molecular biology 2001;305(3):471-9.
2000: Rochet J C; Brownie E R; Oikawa K; Hicks L D; Fraser M E; James M N; Kay C M; Bridger W A; Wolodko W T
Pig heart CoA transferase exists as two oligomeric forms separated by a large kinetic barrier.
Biochemistry 2000;39(37):11291-302.
2000: Ng K K; Petersen J F; Cherney M M; Garen C; Zalatoris J J; Rao-Naik C; Dunn B M; Martzen M R; Peanasky R J; James M N
Structural basis for the inhibition of porcine pepsin by Ascaris pepsin inhibitor-3.
Nature structural biology 2000;7(8):653-7.
2000: Fraser M E; James M N; Bridger W A; Wolodko W T
Phosphorylated and dephosphorylated structures of pig heart, GTP-specific succinyl-CoA synthetase.
Journal of molecular biology 2000;299(5):1325-39.
2000: Fujinaga M; Cherney M M; Tarasova N I; Bartlett P A; Hanson J E; James M N
Structural study of the complex between human pepsin and a phosphorus-containing peptidic -transition-state analog.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 3):272-9.
2000: Bateman K S; Anderson S; Lu W; Qasim M A; Laskowski M; James M N
Deleterious effects of beta-branched residues in the S1 specificity pocket of Streptomyces griseus proteinase B (SGPB): crystal structures of the turkey ovomucoid third domain variants Ile18I, Val18I, Thr18I, and Ser18I in complex with SGPB.
Protein science : a publication of the Protein Society 2000;9(1):83-94.
2000: Parrish J C; Shan R; Knaus E E; James M N
Racemic isopropyl 1,4-dihydro-2,6-dimethyl-4-(6-methyl-2-pyridyl)-3- nitropyridine-5-carboxylate hemibenzene solvate.
Acta crystallographica. Section C, Crystal structure communications 2000;56 ( Pt 1)():107-9.
2000: Joyce M A; Fraser M E; James M N; Bridger W A; Wolodko W T
ADP-binding site of Escherichia coli succinyl-CoA synthetase revealed by x-ray crystallography.
Biochemistry 2000;39(1):17-25.
1999: Bernstein N K; James M N
Novel ways to prevent proteolysis - prophytepsin and proplasmepsin II.
Current opinion in structural biology 1999;9(6):684-9.
1999: Bergmann E M; Cherney M M; Mckendrick J; Frormann S; Luo C; Malcolm B A; Vederas J C; James M N
Crystal structure of an inhibitor complex of the 3C proteinase from hepatitis A virus (HAV) and implications for the polyprotein processing in HAV.
Virology 1999;265(1):153-63.
1999: Petersen J F; Cherney M M; Liebig H D; Skern T; Kuechler E; James M N
The structure of the 2A proteinase from a common cold virus: a proteinase responsible for the shut-off of host-cell protein synthesis.
The EMBO journal 1999;18(20):5463-75.
1999: Khan A R; Khazanovich-Bernstein N; Bergmann E M; James M N
Structural aspects of activation pathways of aspartic protease zymogens and viral 3C protease precursors.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(20):10968-75.
1999: Caputo A; Parrish J C; James M N; Powers J C; Bleackley R C
Electrostatic reversal of serine proteinase substrate specificity.
Proteins 1999;35(4):415-24.
1999: Joyce M A; Fraser M E; Brownie E R; James M N; Bridger W A; Wolodko W T
Probing the nucleotide-binding site of Escherichia coli succinyl-CoA synthetase.
Biochemistry 1999;38(22):7273-83.
1999: Qasim M A; Lu S M; Ding J; Bateman K S; James M N; Anderson S; Song J; Markley J L; Ganz P J; Saunders C W; Laskowski M
Thermodynamic criterion for the conformation of P1 residues of substrates and of inhibitors in complexes with serine proteinases.
Biochemistry 1999;38(22):7142-50.
1999: Bailey D L; Fraser M E; Bridger W A; James M N; Wolodko W T
A dimeric form of Escherichia coli succinyl-CoA synthetase produced by site-directed mutagenesis.
Journal of molecular biology 1999;285(4):1655-66.
1999: Fraser M E; James M N; Bridger W A; Wolodko W T
A detailed structural description of Escherichia coli succinyl-CoA synthetase.
Journal of molecular biology 1999;285(4):1633-53.
1999: Bernstein N K; Cherney M M; Loetscher H; Ridley R G; James M N
Crystal structure of the novel aspartic proteinase zymogen proplasmepsin II from plasmodium falciparum.
Nature structural biology 1999;6(1):32-7.
1998: Fujinaga M; Huang K; Bateman K S; James M N
Computational analysis of the binding of P1 variants of domain 3 of turkey ovomucoid inhibitor to Streptomyces griseus protease B.
Journal of molecular biology 1998;284(5):1683-94.
1998: Khan A R; Parrish J C; Fraser M E; Smith W W; Bartlett P A; James M N
Lowering the entropic barrier for binding conformationally flexible inhibitors to enzymes.
Biochemistry 1998;37(48):16839-45.
1998: Mark B L; Wasney G A; Salo T J; Khan A R; Cao Z; Robbins P W; James M N; Triggs-Raine B L
Structural and functional characterization of Streptomyces plicatus beta-N-acetylhexosaminidase by comparative molecular modeling and site-directed mutagenesis.
The Journal of biological chemistry 1998;273(31):19618-24.
1998: Khan A R; James M N
Molecular mechanisms for the conversion of zymogens to active proteolytic enzymes.
Protein science : a publication of the Protein Society 1998;7(4):815-36.
1998: Petersen J F; Chernaia M M; Rao-Naik C; Zalatoris J L; Dunn B M; James M N
X-ray crystallographic studies of the complex between porcine pepsin and the aspartic proteinase inhibitor PI-3 from the nematode Ascaris suum.
Advances in experimental medicine and biology 1998;436():391-5.
1998: Fraser M E; Meyer J H; Bartlett P A; James M N
Overcoming the unfavourable entropic contribution of ligand binding with a macrocyclic inhibitor bound to penicillopepsin.
Advances in experimental medicine and biology 1998;436():355-9.
1998: Khan A R; Chernaia M M; Tarasova N I; James M N
Crystallographic studies of an activation intermediate of human gastricsin.
Advances in experimental medicine and biology 1998;436():265-70.
1998: Bateman K S; Chernaia M M; Tarasova N I; James M N
Crystal structure of human pepsinogen A.
Advances in experimental medicine and biology 1998;436():259-63.
1997: Khan A R; Cherney M M; Tarasova N I; James M N
Structural characterization of activation 'intermediate 2' on the pathway to human gastricsin.
Nature structural biology 1997;4(12):1010-5.
1997: Mosimann S C; Cherney M M; Sia S; Plotch S; James M N
Refined X-ray crystallographic structure of the poliovirus 3C gene product.
Journal of molecular biology 1997;273(5):1032-47.
1997: Strynadka N C; Cherney M; Sielecki A R; Li M X; Smillie L B; James M N
Structural details of a calcium-induced molecular switch: X-ray crystallographic analysis of the calcium-saturated N-terminal domain of troponin C at 1.75 A resolution.
Journal of molecular biology 1997;273(1):238-55.
1997: Bergmann E M; Mosimann S C; Chernaia M M; Malcolm B A; James M N
The refined crystal structure of the 3C gene product from hepatitis A virus: specific proteinase activity and RNA recognition.
Journal of virology 1997;71(3):2436-48.
1997: Qasim M A; Ganz P J; Saunders C W; Bateman K S; James M N; Laskowski M
Interscaffolding additivity. Association of P1 variants of eglin c and of turkey ovomucoid third domain with serine proteinases.
Biochemistry 1997;36(7):1598-607.
1997: Khan A R; Johnson K A; Braam J; James M N
Comparative modeling of the three-dimensional structure of the calmodulin-related TCH2 protein from Arabidopsis.
Proteins 1997;27(1):144-53.
1996: Fujinaga M; Chernaia M M; Halenbeck R; Koths K; James M N
The crystal structure of PR3, a neutrophil serine proteinase antigen of Wegener's granulomatosis antibodies.
Journal of molecular biology 1996;261(2):267-78.
1996: Mosimann S C; Newton D L; Youle R J; James M N
X-ray crystallographic structure of recombinant eosinophil-derived neurotoxin at 1.83 A resolution.
Journal of molecular biology 1996;260(4):540-52.
1996: Strynadka N C; Jensen S E; Alzari P M; James M N
A potent new mode of beta-lactamase inhibition revealed by the 1.7 A X-ray crystallographic structure of the TEM-1-BLIP complex.
Nature structural biology 1996;3(3):290-7.
1996: Strynadka N C; Eisenstein M; Katchalski-Katzir E; Shoichet B K; Kuntz I D; Abagyan R; Totrov M; Janin J; Cherfils J; Zimmerman F; Olson A; Duncan B; Rao M; Jackson R; Sternberg M; James M N
Molecular docking programs successfully predict the binding of a beta-lactamase inhibitory protein to TEM-1 beta-lactamase.
Nature structural biology 1996;3(3):233-9.
1996: Strynadka N C; James M N
Lysozyme: a model enzyme in protein crystallography.
EXS 1996;75():185-222.
1995: Mosimann S; Meleshko R; James M N
A critical assessment of comparative molecular modeling of tertiary structures of proteins.
Proteins 1995;23(3):301-17.
1995: Huang K; Lu W; Anderson S; Laskowski M; James M N
Water molecules participate in proteinase-inhibitor interactions: crystal structures of Leu18, Ala18, and Gly18 variants of turkey ovomucoid inhibitor third domain complexed with Streptomyces griseus proteinase B.
Protein science : a publication of the Protein Society 1995;4(10):1985-97.
1995: Moore S A; James M N
Structural refinement of the non-fluorescent flavoprotein from Photobacterium leiognathi at 1.60 A resolution.
Journal of molecular biology 1995;249(1):195-214.
1995: Fujinaga M; Chernaia M M; Tarasova N I; Mosimann S C; James M N
Crystal structure of human pepsin and its complex with pepstatin.
Protein science : a publication of the Protein Society 1995;4(5):960-72.
1995: Moore S A; Sielecki A R; Chernaia M M; Tarasova N I; James M N
Crystal and molecular structures of human progastricsin at 1.62 A resolution.
Journal of molecular biology 1995;247(3):466-85.
1994: Moore S A; James M N
Common structural features of the luxF protein and the subunits of bacterial luciferase: evidence for a (beta alpha)8 fold in luciferase.
Protein science : a publication of the Protein Society 1994;3(11):1914-26.
1994: Blanchard H; James M N
A crystallographic re-investigation into the structure of Streptomyces griseus proteinase A reveals an acyl-enzyme intermediate.
Journal of molecular biology 1994;241(4):574-87.
1994: Huang K; Strynadka N C; Bernard V D; Peanasky R J; James M N
The molecular structure of the complex of Ascaris chymotrypsin/elastase inhibitor with porcine elastase.
Structure (London, England : 1993) 1994;2(7):679-89.
1994: Caputo A; James M N; Powers J C; Hudig D; Bleackley R C
Conversion of the substrate specificity of mouse proteinase granzyme B.
Nature structural biology 1994;1(6):364-7.
1994: Allaire M; Chernaia M M; Malcolm B A; James M N
Picornaviral 3C cysteine proteinases have a fold similar to chymotrypsin-like serine proteinases.
Nature 1994;369(6475):72-6.
1994: Strynadka N C; Jensen S E; Johns K; Blanchard H; Page M; Matagne A; Frère J M; James M N
Structural and kinetic characterization of a beta-lactamase-inhibitor protein.
Nature 1994;368(6472):657-60.
1994: Wolodko W T; Fraser M E; James M N; Bridger W A
The crystal structure of succinyl-CoA synthetase from Escherichia coli at 2.5-A resolution.
The Journal of biological chemistry 1994;269(14):10883-90.
1994: Mosimann S C; Ardelt W; James M N
Refined 1.7 A X-ray crystallographic structure of P-30 protein, an amphibian ribonuclease with anti-tumor activity.
Journal of molecular biology 1994;236(4):1141-53.
1994: McPhalen C A; Sielecki A R; Santarsiero B D; James M N
Refined crystal structure of rat parvalbumin, a mammalian alpha-lineage parvalbumin, at 2.0 A resolution.
Journal of molecular biology 1994;235(2):718-32.
1994: Fraser M E; Chernaia M M; Kozlov Y V; James M N
Crystal structure of the holotoxin from Shigella dysenteriae at 2.5 A resolution.
Nature structural biology 1994;1(1):59-64.
1993: Chernaia M M; Malcolm B A; Allaire M; James M N
Hepatitis A virus 3C proteinase: some properties, crystallization and preliminary crystallographic characterization.
Journal of molecular biology 1993;234(3):890-3.
1993: Kozlov Y V; Chernaia M M; Fraser M E; James M N
Purification and crystallization of Shiga toxin from Shigella dysenteriae.
Journal of molecular biology 1993;232(2):704-6.
1993: Moore S A; James M N; O'Kane D J; Lee J
Crystal structure of a flavoprotein related to the subunits of bacterial luciferase.
The EMBO journal 1993;12(5):1767-74.
1992: Mosimann S C; Johns K L; Ardelt W; Mikulski S M; Shogen K; James M N
Comparative molecular modeling and crystallization of P-30 protein: a novel antitumor protein of Rana pipiens oocytes and early embryos.
Proteins 1992;14(3):392-400.
1992: Strynadka N C; Adachi H; Jensen S E; Johns K; Sielecki A; Betzel C; Sutoh K; James M N
Molecular structure of the acyl-enzyme intermediate in beta-lactam hydrolysis at 1.7 A resolution.
Nature 1992;359(6397):700-5.
1992: Church W B; Swenson L; James M N; Mahuran D
Crystallization of human beta-hexosaminidase B.
Journal of molecular biology 1992;227(2):577-80.
1992: Fraser M E; Strynadka N C; Bartlett P A; Hanson J E; James M N
Crystallographic analysis of transition-state mimics bound to penicillopepsin: phosphorus-containing peptide analogues.
Biochemistry 1992;31(22):5201-14.
1992: Huang K; Kodandapani R; Kallwass H; Hogan J K; Parris W; Friesen J D; Gold M; Jones J B; James M N
Crystallization and preliminary X-ray diffraction studies of two mutants of lactate dehydrogenase from Bacillus stearothermophilus.
Proteins 1992;13(2):158-61.
1992: James M N; Sielecki A R; Hayakawa K; Gelb M H
Crystallographic analysis of transition state mimics bound to penicillopepsin: difluorostatine- and difluorostatone-containing peptides.
Biochemistry 1992;31(15):3872-86.
1992: Moore S A; James M N; O'Kane D J; Lee J
Crystallization of Photobacterium leiognathi non-fluorescent flavoprotein, an unusual flavoprotein with limited sequence identity to bacterial luciferase.
Journal of molecular biology 1992;224(2):523-6.
1991: Strynadka N C; James M N
Lysozyme revisited: crystallographic evidence for distortion of an N-acetylmuramic acid residue bound in site D.
Journal of molecular biology 1991;220(2):401-24.
1991: Sielecki A R; Fujinaga M; Read R J; James M N
Refined structure of porcine pepsinogen at 1.8 A resolution.
Journal of molecular biology 1991;219(4):671-92.
1991: Andreeva N S; James M N
Why does pepsin have a negative charge at very low pH? An analysis of conserved charged residues in aspartic proteinases.
Advances in experimental medicine and biology 1991;306():39-45.
1991: McPhalen C A; Strynadka N C; James M N
Calcium-binding sites in proteins: a structural perspective.
Advances in protein chemistry 1991;42():77-144.
1990: Sielecki A R; Fedorov A A; Boodhoo A; Andreeva N S; James M N
Molecular and crystal structures of monoclinic porcine pepsin refined at 1.8 A resolution.
Journal of molecular biology 1990;214(1):143-70.
1990: Strynadka N C; James M N
Model for the interaction of amphiphilic helices with troponin C and calmodulin.
Proteins 1990;7(3):234-48.
1989: Sielecki A R; Hayakawa K; Fujinaga M; Murphy M E; Fraser M; Muir A K; Carilli C T; Lewicki J A; Baxter J D; James M N
Structure of recombinant human renin, a target for cardiovascular-active drugs, at 2.5 A resolution.
Science (New York, N.Y.) 1989;243(4896):1346-51.
1989: Greenblatt H M; Ryan C A; James M N
Structure of the complex of Streptomyces griseus proteinase B and polypeptide chymotrypsin inhibitor-1 from Russet Burbank potato tubers at 2.1 A resolution.
Journal of molecular biology 1989;205(1):201-28.
1989: Strynadka N C; James M N
Crystal structures of the helix-loop-helix calcium-binding proteins.
Annual review of biochemistry 1989;58():951-98.
1988: Herzberg O; James M N
Refined crystal structure of troponin C from turkey skeletal muscle at 2.0 A resolution.
Journal of molecular biology 1988;203(3):761-79.
1988: McPhalen C A; James M N
Structural comparison of two serine proteinase-protein inhibitor complexes: eglin-c-subtilisin Carlsberg and CI-2-subtilisin Novo.
Biochemistry 1988;27(17):6582-98.
1988: Read R J; James M N
Refined crystal structure of Streptomyces griseus trypsin at 1.7 A resolution.
Journal of molecular biology 1988;200(3):523-51.
1988: Strynadka N C; James M N
Two trifluoperazine-binding sites on calmodulin predicted from comparative molecular modeling with troponin-C.
Proteins 1988;3(1):1-17.
1988: Murphy M E; Moult J; Bleackley R C; Gershenfeld H; Weissman I L; James M N
Comparative molecular model building of two serine proteinases from cytotoxic T lymphocytes.
Proteins 1988;4(3):190-204.
1987: Clore G M; Gronenborn A M; James M N; Kjaer M; McPhalen C A; Poulsen F M
Comparison of the solution and X-ray structures of barley serine proteinase inhibitor 2.
Protein engineering 1987;1(4):313-8.
1987: Fujinaga M; Sielecki A R; Read R J; Ardelt W; Laskowski M; James M N
Crystal and molecular structures of the complex of alpha-chymotrypsin with its inhibitor turkey ovomucoid third domain at 1.8 A resolution.
Journal of molecular biology 1987;195(2):397-418.
1987: Fujinaga M; James M N
Rat submaxillary gland serine protease, tonin. Structure solution and refinement at 1.8 A resolution.
Journal of molecular biology 1987;195(2):373-96.
1987: McPhalen C A; James M N
Crystal and molecular structure of the serine proteinase inhibitor CI-2 from barley seeds.
Biochemistry 1987;26(1):261-9.
1986: Moult J; James M N
An algorithm for determining the conformation of polypeptide segments in proteins by systematic search.
Proteins 1986;1(2):146-63.
1986: Williams S P; Bridger W A; James M N
Characterization of the phosphoserine of pepsinogen using 31P nuclear magnetic resonance: corroboration of X-ray crystallographic results.
Biochemistry 1986;25(21):6655-9.
1985: McPhalen C A; Schnebli H P; James M N
Crystal and molecular structure of the inhibitor eglin from leeches in complex with subtilisin Carlsberg.
FEBS letters 1985;188(1):55-8.
1984: Wolodko W T; James M N; Bridger W A
Crystallization of succinyl-CoA synthetase from Escherichia coli.
The Journal of biological chemistry 1984;259(8):5316-20.
1983: Read R J; Fujinaga M; Sielecki A R; James M N
Structure of the complex of Streptomyces griseus protease B and the third domain of the turkey ovomucoid inhibitor at 1.8-A resolution.
Biochemistry 1983;22(19):4420-33.
1983: McPhalen C A; Evans C; Hayakawa K; Jonassen I; Svendsen I; James M N
Preliminary crystallographic data for the serine protease inhibitor CI-2 from barley seeds.
Journal of molecular biology 1983;168(2):445-7.
1982: Fujinaga M; Read R J; Sielecki A; Ardelt W; Laskowski M; James M N
Refined crystal structure of the molecular complex of Streptomyces griseus protease B, a serine protease, with the third domain of the ovomucoid inhibitor from turkey.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(16):4868-72.

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