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Jill James

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Igor Koturbash; Stepan Melnyk; Frederick A Beland; S Jill James; Igor P Pogribny
Role of epigenetic and miR-22 and miR-29b alterations in the downregulation of Mat1a and Mthfr genes in early preneoplastic livers in rats induced by 2-acetylaminofluorene.
Mei Zhao; Vanessa da Silva; Timothy J Garrett; S Jill James; Stephan Melnyk; Maria A Ralat; Jesse F Gregory
Vitamin B-6 restriction impairs fatty acid synthesis in cultured human hepatoma (HepG2) cells.
Sarah J Blossom; Craig A Cooney; Kathleen M Gilbert; Stepan Melnyk; S Jill James
Postnatal exposure to trichloroethylene alters glutathione redox homeostasis, methylation potential, and neurotrophin expression in the mouse hippocampus.

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2013: Igor Koturbash; Stepan Melnyk; Frederick A Beland; S Jill James; Igor P Pogribny
Role of epigenetic and miR-22 and miR-29b alterations in the downregulation of Mat1a and Mthfr genes in early preneoplastic livers in rats induced by 2-acetylaminofluorene.
Molecular carcinogenesis 2013;52(4):318-27.
2013: Mei Zhao; Vanessa da Silva; Timothy J Garrett; S Jill James; Stephan Melnyk; Maria A Ralat; Jesse F Gregory
Vitamin B-6 restriction impairs fatty acid synthesis in cultured human hepatoma (HepG2) cells.
American journal of physiology. Endocrinology and metabolism 2013;304(4):E342-51.
2012: Sarah J Blossom; Craig A Cooney; Kathleen M Gilbert; Stepan Melnyk; S Jill James
Postnatal exposure to trichloroethylene alters glutathione redox homeostasis, methylation potential, and neurotrophin expression in the mouse hippocampus.
Neurotoxicology 2012;33(6):1518-27.
2012: Ann Reynolds; Brianne Schmidt; Patricia A Stewart; Nikki Withrow; S Jill James; Cynthia Johnson; Susan L Johnson; Nancy F Krebs; Cynthia Molloy; Harriet Austin; Traci Clemons; Susan L Hyman
Iron status in children with autism spectrum disorder.
Pediatrics 2012;130 Suppl 2():S154-9.
2012: Susan L Hyman; S Jill James; Cynthia Johnson; Nicole Lemcke; Cynthia Molloy; Usa Cain; Traci Clemons; Patty Manning Courtney; Jennifer T Foley; Benjamin Handen; Robin Peck; Ann Reynolds; Brianne Schmidt; Patricia A Stewart; Philip K Ng
Nutrient intake from food in children with autism.
Pediatrics 2012;130 Suppl 2():S145-53.
2012: Shimul Chowdhury; Mario A Cleves; Charlotte A Hobbs; Ping Hu; S Jill James; Stewart L MacLeod; Stepan Melnyk; Stephen W Erickson
Associations between maternal genotypes and metabolites implicated in congenital heart defects.
Molecular genetics and metabolism 2012;107(3):596-604.
2012: Shannon Rose; Lisa Seidel; Timothy A Trusty; Jingyun Li; Stepan Melnyk; Todd Nick; Oleksandra Pavliv; S Jill James
Intracellular and extracellular redox status and free radical generation in primary immune cells from children with autism.
Autism research and treatment 2012;2012():986519.
2011: Marian L Neuhouser; H Frederik Nijhout; Michael C Reed; Barry Shane; Jesse F Gregory; S Jill James; Amy Liu; Cornelia M Ulrich
Mathematical modeling predicts the effect of folate deficiency and excess on cancer-related biomarkers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2011;20(9):1912-7.
2011: Shimul Chowdhury; Mario A Cleves; Stewart L MacLeod; S Jill James; Weizhi Zhao; Charlotte A Hobbs
Maternal DNA hypomethylation and congenital heart defects.
Birth defects research. Part A, Clinical and molecular teratology 2011;91(2):69-76.
2010: Baiqing Tang; Aladdin Mustafa; Sapna Gupta; Stepan Melnyk; S Jill James; warren kruger
Methionine-deficient diet induces post-transcriptional downregulation of cystathionine β-synthase.
Nutrition (Burbank, Los Angeles County, Calif.) 2010;26(11-12):1170-5.
2010: S Jill James; Stepan Melnyk; Stefanie Jernigan; Oleksandra Pavliv; Timothy Trusty; Sara Lehman; Lisa Seidel; David W Gaylor; Mario A Cleves
A functional polymorphism in the reduced folate carrier gene and DNA hypomethylation in mothers of children with autism.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010;153B(6):1209-20.
2009: S Jill James; Shannon Rose; Stepan Melnyk; Stefanie Jernigan; Sarah Blossom; Oleksandra Pavliv; David W Gaylor
Cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from children with autism.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(8):2374-83.
2009: S Jill James; Stepan Melnyk; George Fuchs; Tyra Reid; Stefanie Jernigan; Oleksandra Pavliv; Amanda Hubanks; David W Gaylor
Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism.
The American journal of clinical nutrition 2009;89(1):425-30.
2008: S Jill James; Stepan Melnyk; Stefanie Jernigan; Amanda Hubanks; Shannon Rose; David W Gaylor
Abnormal Transmethylation/transsulfuration Metabolism and DNA Hypomethylation Among Parents of Children with Autism.
Journal of autism and developmental disorders 2008;38(10):1976.
2008: Sarah J Blossom; Jason C Doss; Leah J Hennings; Stefanie Jernigan; Stepan Melnyk; S Jill James
Developmental exposure to trichloroethylene promotes CD4+ T cell differentiation and hyperactivity in association with oxidative stress and neurobehavioral deficits in MRL+/+ mice.
Toxicology and applied pharmacology 2008;231(3):344-53.
2008: Cornelia M Ulrich; Marian L Neuhouser; Amy Y Liu; Alanna Boynton; Jesse F Gregory; Barry Shane; S Jill James; Michael C Reed; H Frederik Nijhout
Mathematical modeling of folate metabolism: predicted effects of genetic polymorphisms on mechanisms and biomarkers relevant to carcinogenesis.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008;17(7):1822-31.
2008: Basak Celtikci; Daniel Leclerc; Andrea K Lawrance; Liyuan Deng; Hana C Friedman; Natalia I Krupenko; Sergey A Krupenko; Stepan Melnyk; S Jill James; Alan Peterson; Rima Rozen
Altered expression of methylenetetrahydrofolate reductase modifies response to methotrexate in mice.
Pharmacogenetics and genomics 2008;18(7):577-89.
2008: Deqiang Li; N Karp; Qing Wu; X-L Wang; Stepan Melnyk; S Jill James; Rima Rozen
Mefolinate (5-methyltetrahydrofolate), but not folic acid, decreases mortality in an animal model of severe methylenetetrahydrofolate reductase deficiency.
Journal of inherited metabolic disease 2008;31(3):403-11.
2008: Michael C Reed; Rachel L Thomas; Jovana Pavisic; S Jill James; Cornelia M Ulrich; H Frederik Nijhout
A mathematical model of glutathione metabolism.
Theoretical biology & medical modelling 2008;5():8.
2007: Sheila M Innis; A George F Davidson; Stepan Melynk; S Jill James
Choline-related supplements improve abnormal plasma methionine-homocysteine metabolites and glutathione status in children with cystic fibrosis.
The American journal of clinical nutrition 2007;85(3):702-8.
2007: Daniel A Rossignol; Lanier W Rossignol; S Jill James; Stepan Melnyk; Elizabeth Mumper
The effects of hyperbaric oxygen therapy on oxidative stress, inflammation, and symptoms in children with autism: an open-label pilot study.
BMC pediatrics 2007;7():36.
2006: S Jill James; Stepan Melnyk; Stefanie Jernigan; Mario A Cleves; Charles H Halsted; Donna H Wong; Paul Cutler; Kenneth Bock; Marvin Boris; J Jeffrey Bradstreet; Sidney M Baker; David W Gaylor
Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2006;141B(8):947-56.
2006: Michael C Reed; H Frederik Nijhout; Marian L Neuhouser; Jesse F Gregory; Barry Shane; S Jill James; Alanna Boynton; Cornelia M Ulrich
A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism.
The Journal of nutrition 2006;136(10):2653-61.
2006: Jesus A Villanueva; Farah Esfandiari; Donna H Wong; Iram Ahmad; Stepan Melnyk; S Jill James; Charles H Halsted
Abnormal transsulfuration and glutathione metabolism in the micropig model of alcoholic liver disease.
Alcoholism, clinical and experimental research 2006;30(7):1262-70.
2006: H Frederik Nijhout; Michael C Reed; David F Anderson; Jonathan C Mattingly; S Jill James; Cornelia M Ulrich
Long-range allosteric interactions between the folate and methionine cycles stabilize DNA methylation reaction rate.
Epigenetics : official journal of the DNA Methylation Society 2006;1(2):81-7.
2006: Weizhi Zhao; Bridget Mosley; Mario A Cleves; Stepan Melnyk; S Jill James; Charlotte A Hobbs
Neural tube defects and maternal biomarkers of folate, homocysteine, and glutathione metabolism.
Birth defects research. Part A, Clinical and molecular teratology 2006;76(4):230-6.
2006: Xingrao Ke; Q Lei; S Jill James; S L Kelleher; Stepan Melnyk; Stefanie Jernigan; Xing Yu; Laiyi Wang; Christopher W Callaway; Gurmail Gill; Gary M Chan; Kurt H Albertine; Robert A McKnight; Robert H Lane
Uteroplacental insufficiency affects epigenetic determinants of chromatin structure in brains of neonatal and juvenile IUGR rats.
Physiological genomics 2006;25(1):16-28.
2006: Charlotte A Hobbs; Sadia Malik; Weizhi Zhao; S Jill James; Stepan Melnyk; Mario A Cleves
Maternal homocysteine and congenital heart defects.
Journal of the American College of Cardiology 2006;47(3):683-5.
2006: Charlotte A Hobbs; S Jill James; Abbas Parsian; P A Krakowiak; Stefanie Jernigan; J J Greenhaw; Y Lu; Mario A Cleves
Congenital heart defects and genetic variants in the methylenetetrahydroflate reductase gene.
Journal of medical genetics 2006;43(2):162-6.
2006: Igor P Pogribny; Sharon A Ross; Carolyn Wise; Marta Pogribna; Elisabeth A Jones; Volodymyr Tryndyak; S Jill James; Yvonne P Dragan; Lionel A Poirier
Irreversible global DNA hypomethylation as a key step in hepatocarcinogenesis induced by dietary methyl deficiency.
Mutation research 2006;593(1-2):80-7.
2006: Charlotte A Hobbs; S Jill James; Stefanie Jernigan; Stepan Melnyk; Yunxia Lu; Sadia Malik; Mario A Cleves
Congenital heart defects, maternal homocysteine, smoking, and the 677 C>T polymorphism in the methylenetetrahydrofolate reductase gene: evaluating gene-environment interactions.
American journal of obstetrics and gynecology 2006;194(1):218-24.
2005: Charlotte A Hobbs; Mario A Cleves; Weizhi Zhao; Stepan Melnyk; S Jill James
Congenital heart defects and maternal biomarkers of oxidative stress.
The American journal of clinical nutrition 2005;82(3):598-604.
2005: Abalo Chango; Nathalie Fillon-Emery; Clotilde Mircher; Henri Bléhaut; Daniel Lambert; Bernard Herbeth; S Jill James; Marie-Odile Réthoré; Jean Pierre Nicolas
No association between common polymorphisms in genes of folate and homocysteine metabolism and the risk of Down's syndrome among French mothers.
The British journal of nutrition 2005;94(2):166-9.
2005: Charlotte A Hobbs; Mario A Cleves; Carmen Keith; Sadia Ghaffar; S Jill James
NKX2.5 and congenital heart defects: A population-based study.
American journal of medical genetics. Part A 2005;134A(2):223-5.
2005: Alice H Chen; Sheila M Innis; A George F Davidson; S Jill James
Phosphatidylcholine and lysophosphatidylcholine excretion is increased in children with cystic fibrosis and is associated with plasma homocysteine, S-adenosylhomocysteine, and S-adenosylmethionine.
The American journal of clinical nutrition 2005;81(3):686-91.
2005: Ofer Spiegelstein; Aron Troen; S Jill James; X Chris Le; Xiufen Lu; Stepan Melnyk; Jacob Selhub; Richard H Finnell
Effects of dietary folate intake and folate binding protein-2 (Folbp2) on urinary speciation of sodium arsenate in mice.
Environmental toxicology and pharmacology 2005;19(1):1-7.
2005: Charlotte A Hobbs; Mario A Cleves; Stepan Melnyk; Weizhi Zhao; S Jill James
Congenital heart defects and abnormal maternal biomarkers of methionine and homocysteine metabolism.
The American journal of clinical nutrition 2005;81(1):147-53.
2005: S Jill James; William Slikker; Stepan Melnyk; Elizabeth New; Marta Pogribna; Stefanie Jernigan
Thimerosal neurotoxicity is associated with glutathione depletion: protection with glutathione precursors.
Neurotoxicology 2005;26(1):1-8.
2004: S Jill James; Paul Cutler; Stepan Melnyk; Stefanie Jernigan; Laurette Janak; David W Gaylor; James A Neubrander
Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism.
The American journal of clinical nutrition 2004;80(6):1611-7.
2004: Bernd Schwahn; Maurice D Laryea; Zhoutao Chen; Stepan Melnyk; Igor P Pogribny; Timothy A Garrow; S Jill James; Rima Rozen
Betaine rescue of an animal model with methylenetetrahydrofolate reductase deficiency.
The Biochemical journal 2004;382(Pt 3):831-40.
2004: Jeffrey W Taub; Gina Mundschau; Yubin Ge; Janet Poulik; Faisal Qureshi; Tanya Jensen; S Jill James; Larry H Matherly; Joshua Wechsler; John D Crispino
Prenatal origin of GATA1 mutations may be an initiating step in the development of megakaryocytic leukemia in Down syndrome.
Blood 2004;104(5):1588-9.
2004: Nicole K MacLennan; S Jill James; Stepan Melnyk; Ali Piroozi; Stefanie Jernigan; Jennifer L Hsu; Sara M Janke; Tho D Pham; Robert H Lane
Uteroplacental insufficiency alters DNA methylation, one-carbon metabolism, and histone acetylation in IUGR rats.
Physiological genomics 2004;18(1):43-50.
2004: S Jill James
Maternal metabolic phenotype and risk of Down syndrome: beyond genetics.
American journal of medical genetics. Part A 2004;127A(1):1-4.
2004: Igor P Pogribny; S Jill James; Stefanie Jernigan; Marta Pogribna
Genomic hypomethylation is specific for preneoplastic liver in folate/methyl deficient rats and does not occur in non-target tissues.
Mutation research 2004;548(1-2):53-9.
2004: Ivo Baric; Ksenija Fumic; Byron Glenn; Mario Cuk; Andreas Schulze; James D Finkelstein; S Jill James; Vlatka Mejaski-Bosnjak; Leo Pazanin; Igor P Pogribny; Marko Rados; Vladimir Sarnavka; Mira Scukanec-Spoljar; Robert H Allen; Sally P Stabler; Lidija Uzelac; Oliver Vugrek; Conrad Wagner; Steven H Zeisel; S Harvey Mudd
S-adenosylhomocysteine hydrolase deficiency in a human: a genetic disorder of methionine metabolism.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(12):4234-9.
2003: Farah Esfandiari; Ralph Green; Rebecca F Cotterman; Igor P Pogribny; S Jill James; Joshua Miller
Methyl deficiency causes reduction of the methyl-CpG-binding protein, MeCP2, in rat liver.
Carcinogenesis 2003;24(12):1935-40.
2003: Ofer Spiegelstein; Xiufen Lu; X Chris Le; Aron Troen; Jacob Selhub; Stepan Melnyk; S Jill James; Richard Finnell
Effects of dietary folate intake and folate binding protein-1 (Folbp1) on urinary speciation of sodium arsenate in mice.
Toxicology letters 2003;145(2):167-74.
2003: S Jill James; Igor P Pogribny; Marta Pogribna; Barbara J Miller; Stefanie Jernigan; Stepan Melnyk
Mechanisms of DNA damage, DNA hypomethylation, and tumor progression in the folate/methyl-deficient rat model of hepatocarcinogenesis.
The Journal of nutrition 2003;133(11 Suppl 1):3740S-3747S.
2003: Tasneem Motiwala; Kalpana Ghoshal; Anindita Das; Sarmila Majumder; Dieter Weichenhan; Yue-Zhong Wu; Kristen Holman; S Jill James; Samson T Jacob; Christoph Plass
Suppression of the protein tyrosine phosphatase receptor type O gene (PTPRO) by methylation in hepatocellular carcinomas.
Oncogene 2003;22(41):6319-31.
2003: Sheila M Innis; A George F Davidson; Alice Chen; Roger Dyer; Stepan Melnyk; S Jill James
Increased plasma homocysteine and S-adenosylhomocysteine and decreased methionine is associated with altered phosphatidylcholine and phosphatidylethanolamine in cystic fibrosis.
The Journal of pediatrics 2003;143(3):351-6.
2003: Olga Kovalchuk; Paula Burke; Andrey Arkhipov; Nikolaj Kuchma; S Jill James; Igor Kovalchuk; Igor P Pogribny
Genome hypermethylation in Pinus silvestris of Chernobyl--a mechanism for radiation adaptation?
Mutation research 2003;529(1-2):13-20.
2003: Ann M Winter-Vann; Barton A. Kamen; Martin O Bergo; Stephen G Young; Stepan Melnyk; S Jill James; Patrick J Casey
Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(11):6529-34.
2003: Ralph Carmel; Stepan Melnyk; S Jill James
Cobalamin deficiency with and without neurologic abnormalities: differences in homocysteine and methionine metabolism.
Blood 2003;101(8):3302-8.
2003: Jacquetta M Trasler; Liyuan Deng; Stepan Melnyk; Igor P Pogribny; Francois Hiou-Tim; Sahar Sibani; Christopher C Oakes; En Li; S Jill James; Rima Rozen
Impact of Dnmt1 deficiency, with and without low folate diets, on tumor numbers and DNA methylation in Min mice.
Carcinogenesis 2003;24(1):39-45.
2002: Igor P Pogribny; S Jill James
De novo methylation of the p16INK4A gene in early preneoplastic liver and tumors induced by folate/methyl deficiency in rats.
Cancer letters 2002;187(1-2):69-75.
2002: Charlotte A Hobbs; Mario A Cleves; Ronald M Lauer; Trudy L Burns; S Jill James
Preferential transmission of the MTHFR 677 T allele to infants with Down syndrome: implications for a survival advantage.
American journal of medical genetics 2002;113(1):9-14.
2002: Abalo Chango; Clotilde Mircher; S Jill James; Marie-Odile Réthoré; Jean Pierre Nicolas
[One carbon metabolism and trisomy 21: analysis of the genetic polymorphism].
Annales de biologie clinique 2002;60(6):647-53.
2002: Yubin Ge; T Jensen; S Jill James; David L Becton; Gita V Massey; Howard J Weinstein; Yaddanapudi Ravindranath; Larry H Matherly; Jeffrey W Taub
High frequency of the 844ins68 cystathionine-beta-synthase gene variant in Down syndrome children with acute myeloid leukemia.
Leukemia 2002;16(11):2339-41.
2002: S Jill James; Stepan Melnyk; Marta Pogribna; Igor P Pogribny; Marie A Caudill
Elevation in S-adenosylhomocysteine and DNA hypomethylation: potential epigenetic mechanism for homocysteine-related pathology.
The Journal of nutrition 2002;132(8 Suppl):2361S-2366S.
2002: Charles H Halsted; Jesus A Villanueva; Angela M Devlin; Onni Niemelä; Seppo Parkkila; Timothy A Garrow; Lynn M Wallock; Mark K Shigenaga; Stepan Melnyk; S Jill James
Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(15):10072-7.
2002: Ralph Carmel; S Jill James
Alcohol abuse: an important cause of severe hyperhomocysteinemia.
Nutrition reviews 2002;60(7 Pt 1):215-21.
2002: Richard A Drachtman; Peter Cole; Carla B Golden; S Jill James; Stepan Melnyk; Joseph Aisner; Barton A. Kamen
Dextromethorphan is effective in the treatment of subacute methotrexate neurotoxicity.
Pediatric hematology and oncology 2002;19(5):319-27.
2002: Scott A Christopher; Stepan Melnyk; S Jill James; warren kruger
S-adenosylhomocysteine, but not homocysteine, is toxic to yeast lacking cystathionine beta-synthase.
Molecular genetics and metabolism 2002;75(4):335-43.
2002: Igor P Pogribny; S Jill James
Reduction of p53 gene expression in human primary hepatocellular carcinoma is associated with promoter region methylation without coding region mutation.
Cancer letters 2002;176(2):169-74.
2002: Charles H Halsted; Jesus A Villanueva; Angela M Devlin; S Jill James
Interactions of ethanol and folate deficiency in development of alcoholic liver disease in the micropig.
Transactions of the American Clinical and Climatological Association 2002;113():151-62; discussion 162-3.
2002: Sahar Sibani; Stepan Melnyk; Igor P Pogribny; Wei Wang; Francois Hiou-Tim; Liyuan Deng; Jacquetta M Trasler; S Jill James; Rima Rozen
Studies of methionine cycle intermediates (SAM, SAH), DNA methylation and the impact of folate deficiency on tumor numbers in Min mice.
Carcinogenesis 2002;23(1):61-5.
2001: Marie A Caudill; J C Wang; Stepan Melnyk; Igor P Pogribny; Stefanie Jernigan; Michael D Collins; J Santos-Guzman; Marian E Swendseid; Edward A Cogger; S Jill James
Intracellular S-adenosylhomocysteine concentrations predict global DNA hypomethylation in tissues of methyl-deficient cystathionine beta-synthase heterozygous mice.
The Journal of nutrition 2001;131(11):2811-8.
2001: Lihadh Al-Gazali; Rengasamy Padmanabhan; Stepan Melnyk; Ping Yi; Igor P Pogribny; Marta Pogribna; Mahmood Bakir; Z A Hamid; Yousef M Abdulrazzaq; Adekunle Dawodu; S Jill James
Abnormal folate metabolism and genetic polymorphism of the folate pathway in a child with Down syndrome and neural tube defect.
American journal of medical genetics 2001;103(2):128-32.
2001: Marta Pogribna; Stepan Melnyk; Igor P Pogribny; Abalo Chango; Ping Yi; S Jill James
Homocysteine metabolism in children with Down syndrome: in vitro modulation.
American journal of human genetics 2001;69(1):88-95.
2001: Deborah K Hansen; T F Grafton; Stepan Melnyk; S Jill James
Lack of embryotoxicity of homocysteine thiolactone in mouse embryos in vitro.
Reproductive toxicology (Elmsford, N.Y.) 2001;15(3):239-44.
2001: Zhoutao Chen; Andrew C Karaplis; S L Ackerman; Igor P Pogribny; Stepan Melnyk; Suzanne Lussier-Cacan; Moy Fong Chen; Aditya Pai; S W John; R S Smith; Teodoro Bottiglieri; P Bagley; Jacob Selhub; M A Rudnicki; S Jill James; Rima Rozen
Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition.
Human molecular genetics 2001;10(5):433-43.
2000: Ping Yi; Stepan Melnyk; Marta Pogribna; Igor P Pogribny; R Jean Hine; S Jill James
Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation.
The Journal of biological chemistry 2000;275(38):29318-23.
2000: R Jean Hine; S Jill James
Down syndrome and folic acid update.
Journal of the American Dietetic Association 2000;100(9):1004.
2000: Charlotte A Hobbs; Stephanie L Sherman; Ping Yi; Sarah E Hopkins; Claudine P Torfs; R Jean Hine; Marta Pogribna; R Rozen; S Jill James
Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome.
American journal of human genetics 2000;67(3):623-30.
2000: Igor P Pogribny; Marta Pogribna; J K Christman; S Jill James
Single-site methylation within the p53 promoter region reduces gene expression in a reporter gene construct: possible in vivo relevance during tumorigenesis.
Cancer research 2000;60(3):588-94.
2000: Stepan Melnyk; Marta Pogribna; Igor P Pogribny; Ping Yi; S Jill James
Measurement of plasma and intracellular S-adenosylmethionine and S-adenosylhomocysteine utilizing coulometric electrochemical detection: alterations with plasma homocysteine and pyridoxal 5'-phosphate concentrations.
Clinical chemistry 2000;46(2):265-72.
1999: Stepan Melnyk; Marta Pogribna; Barbara J Miller; AG Basnakian; Igor P Pogribny; S Jill James
Uracil misincorporation, DNA strand breaks, and gene amplification are associated with tumorigenic cell transformation in folate deficient/repleted Chinese hamster ovary cells.
Cancer letters 1999;146(1):35-44.
1999: S Jill James; Marta Pogribna; Igor P Pogribny; Stepan Melnyk; R Jean Hine; J B Gibson; Ping Yi; D L Tafoya; D H Swenson; V L Wilson; David W Gaylor
Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome.
The American journal of clinical nutrition 1999;70(4):495-501.
1999: Igor P Pogribny; Ping Yi; S Jill James
A sensitive new method for rapid detection of abnormal methylation patterns in global DNA and within CpG islands.
Biochemical and biophysical research communications 1999;262(3):624-8.
1999: Stepan Melnyk; Marta Pogribna; Igor P Pogribny; R Jean Hine; S Jill James
A new HPLC method for the simultaneous determination of oxidized and reduced plasma aminothiols using coulometric electrochemical detection.
The Journal of nutritional biochemistry 1999;10(8):490-7.
1998: K L Steinmetz; I P Pogribny; S Jill James; Henry C Pitot
Hypomethylation of the rat glutathione S-transferase pi (GSTP) promoter region isolated from methyl-deficient livers and GSTP-positive liver neoplasms.
Carcinogenesis 1998;19(8):1487-94.
1998: Robert A Jacob; D M Gretz; P C Taylor; S Jill James; Igor P Pogribny; Barbara J Miller; Susanne M Henning; Marian E Swendseid
Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in postmenopausal women.
The Journal of nutrition 1998;128(7):1204-12.
1998: S Jill James; Levan Muskhelishvili; David W Gaylor; Angelo Turturro; R Hart
Upregulation of apoptosis with dietary restriction: implications for carcinogenesis and aging.
Environmental health perspectives 1998;106 Suppl 1():307-12.
1997: Igor P Pogribny; Levan Muskhelishvili; Barbara J Miller; S Jill James
Presence and consequence of uracil in preneoplastic DNA from folate/methyl-deficient rats.
Carcinogenesis 1997;18(11):2071-6.
1997: CD Jackson; Constance C Weis; Barbara J Miller; S Jill James
Dietary nucleotides: effects on cell proliferation following partial hepatectomy in rats fed NIH-31, AIN-76A, or folate/methyl-deficient diets.
The Journal of nutrition 1997;127(5 Suppl):834S-837S.
1997: Igor P Pogribny; Barbara J Miller; S Jill James
Alterations in hepatic p53 gene methylation patterns during tumor progression with folate/methyl deficiency in the rat.
Cancer letters 1997;115(1):31-8.
1997: S Jill James; Barbara J Miller; AG Basnakian; Igor P Pogribny; Marta Pogribna; Levan Muskhelishvili
Apoptosis and proliferation under conditions of deoxynucleotide pool imbalance in liver of folate/methyl deficient rats.
Carcinogenesis 1997;18(2):287-93.
1997: Y I Kim; Igor P Pogribny; AG Basnakian; Joshua Miller; Jacob Selhub; S Jill James; J B Mason
Folate deficiency in rats induces DNA strand breaks and hypomethylation within the p53 tumor suppressor gene.
The American journal of clinical nutrition 1997;65(1):46-52.
1996: Levan Muskhelishvili; Angelo Turturro; Ronald W Hart; S Jill James
Pi-class glutathione-S-transferase-positive hepatocytes in aging B6C3F1 mice undergo apoptosis induced by dietary restriction.
The American journal of pathology 1996;149(5):1585-91.
1996: Young-In Kim; Igor P Pogribny; R N Salomon; S W Choi; D E Smith; S Jill James; J B Mason
Exon-specific DNA hypomethylation of the p53 gene of rat colon induced by dimethylhydrazine. Modulation by dietary folate.
The American journal of pathology 1996;149(4):1129-37.
1996: S V Pravdenkova; A G Basnakian; S Jill James; B J Andersen
DNA fragmentation and nuclear endonuclease activity in rat brain after severe closed head injury.
Brain research 1996;729(2):151-5.
1996: A G Basnakian; S Jill James
Quantification of 3'OH DNA breaks by random oligonucleotide-primed synthesis (ROPS) assay.
DNA and cell biology 1996;15(3):255-62.
1996: Charles H Halsted; J Villanueva; C J Chandler; S P Stabler; R H Allen; Levan Muskhelishvili; S Jill James; L Poirier
Ethanol feeding of micropigs alters methionine metabolism and increases hepatocellular apoptosis and proliferation.
Hepatology (Baltimore, Md.) 1996;23(3):497-505.
1996: William H Tolleson; William B Melchior; Suzanne M Morris; Lynda J McGarrity; Olen E Domon; Levan Muskhelishvili; S Jill James; Paul C Howard
Apoptotic and anti-proliferative effects of fumonisin B1 in human keratinocytes, fibroblasts, esophageal epithelial cells and hepatoma cells.
Carcinogenesis 1996;17(2):239-49.
1995: Igor P Pogribny; Lionel A Poirier; S Jill James
Differential sensitivity to loss of cytosine methyl groups within the hepatic p53 gene of folate/methyl deficient rats.
Carcinogenesis 1995;16(11):2863-7.
1995: Levan Muskhelishvili; Ronald W Hart; Angelo Turturro; S Jill James
Age-related changes in the intrinsic rate of apoptosis in livers of diet-restricted and ad libitum-fed B6C3F1 mice.
The American journal of pathology 1995;147(1):20-4.
1995: Igor P Pogribny; A G Basnakian; Barbara J Miller; N G Lopatina; Lionel A Poirier; S Jill James
Breaks in genomic DNA and within the p53 gene are associated with hypomethylation in livers of folate/methyl-deficient rats.
Cancer research 1995;55(9):1894-901.
1995: Deborah K Hansen; T F Grafton; D R Cross; S Jill James
Partial attenuation of hydroxyurea-induced embryotoxicity by deoxyribonucleotides in mouse and rat embryos treated in vitro.
Toxicology in vitro : an international journal published in association with BIBRA 1995;9(1):11-9.
1994: S Jill James; Levan Muskhelishvili
Rates of apoptosis and proliferation vary with caloric intake and may influence incidence of spontaneous hepatoma in C57BL/6 x C3H F1 mice.
Cancer research 1994;54(21):5508-10.
1994: S Jill James; A G Basnakian; Barbara J Miller
In vitro folate deficiency induces deoxynucleotide pool imbalance, apoptosis, and mutagenesis in Chinese hamster ovary cells.
Cancer research 1994;54(19):5075-80.
1994: A G Basnakian; S Jill James
A rapid and sensitive assay for the detection of DNA fragmentation during early phases of apoptosis.
Nucleic acids research 1994;22(13):2714-5.
1994: N A Littlefield; Bruce Hass; S Jill James; Lionel A Poirier
Protective effect of magnesium on DNA strand breaks induced by nickel or cadmium.
Cell biology and toxicology 1994;10(2):127-35.
1993: S Jill James; Barbara J Miller; D R Cross; Lynda J McGarrity; Suzanne M Morris
The essentiality of folate for the maintenance of deoxynucleotide precursor pools, DNA synthesis, and cell cycle progression in PHA-stimulated lymphocytes.
Environmental health perspectives 1993;101 Suppl 5():173-8.
1993: D R Cross; Barbara J Miller; S Jill James
A simplified HPLC method for simultaneously quantifying ribonucleotides and deoxyribonucleotides in cell extracts or frozen tissues.
Cell proliferation 1993;26(4):327-36.
1992: S Jill James; D R Cross; Barbara J Miller
Alterations in nucleotide pools in rats fed diets deficient in choline, methionine and/or folic acid.
Carcinogenesis 1992;13(12):2471-4.
1989: S Jill James; L Yin
Diet-induced DNA damage and altered nucleotide metabolism in lymphocytes from methyl-donor-deficient rats.
Carcinogenesis 1989;10(7):1209-14.
1989: S Jill James; L Yin; Marian E Swendseid
DNA strand break accumulation, thymidylate synthesis and NAD levels in lymphocytes from methyl donor-deficient rats.
The Journal of nutrition 1989;119(4):661-4.