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William James

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Laura Bernstone; Bonnie van Wilgenburg; William James
Several commercially available anti-CCR5 monoclonal antibodies lack specificity and should be used with caution.
Rui André Saraiva Raposo; Benjamin Thomas; David C Trudgian; Bonnie van Wilgenburg; Sally A Cowley; William James
Protein kinase C and NF-κB-dependent CD4 downregulation in macrophages induced by T cell-derived soluble factors: consequences for HIV-1 infection.
M D Moore; P G Spear; P G Stockley; D H J Bunka; Mario Forzan; I McGowan; William James
Generation of neutralizing aptamers against herpes simplex virus type 2: potential components of multivalent microbicides.

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All Publications

2012: Laura Bernstone; Bonnie van Wilgenburg; William James
Several commercially available anti-CCR5 monoclonal antibodies lack specificity and should be used with caution.
Hybridoma (2005) 2012;31(1):7-19.
2011: Rui André Saraiva Raposo; Benjamin Thomas; David C Trudgian; Bonnie van Wilgenburg; Sally A Cowley; William James
Protein kinase C and NF-κB-dependent CD4 downregulation in macrophages induced by T cell-derived soluble factors: consequences for HIV-1 infection.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(2):748-59.
2011: M D Moore; P G Spear; P G Stockley; D H J Bunka; Mario Forzan; I McGowan; William James
Generation of neutralizing aptamers against herpes simplex virus type 2: potential components of multivalent microbicides.
The Journal of general virology 2011;92(Pt 7):1493-9.
2011: Gemma C Carter; Laura Bernstone; Darshan Baskaran; William James
HIV-1 infects macrophages by exploiting an endocytic route dependent on dynamin, Rac1 and Pak1.
Virology 2011;409(2):234-50.
2011: Rui André Saraiva Raposo; Benjamin Thomas; Gabriela Ridlova; William James
Proteomic-based identification of CD4-interacting proteins in human primary macrophages.
PloS one 2011;6(4):e18690.
2010: Xia Xu; Sally Cowley; Christopher J Flaim; William James; Leonard Seymour; Zhanfeng Cui
The roles of apoptotic pathways in the low recovery rate after cryopreservation of dissociated human embryonic stem cells.
Biotechnology progress 2010;26(3):827-37.
2010: Xia Xu; Sally Cowley; Christopher J Flaim; William James; Lenard W Seymour; Zhanfeng Cui
Enhancement of cell recovery for dissociated human embryonic stem cells after cryopreservation.
Biotechnology progress 2010;26(3):781-8.
2009: Abdessamad Tahiri-Alaoui; Daiki Matsuda; Hongtao Xu; Panopoulos Panagiotis; Luke Burman; Luke S Lambeth; Petherbridge Lawrence; William James; Vincent Mauro; Venugopal Nair
The 5' leader of the mRNA encoding the marek's disease virus serotype 1 pp14 protein contains an intronic internal ribosome entry site with allosteric properties.
Journal of virology 2009;83(24):12769-78.
2009: Abdessamad Tahiri-Alaoui; Lorraine P Smith; Suzan Baigent; Lydia Kgosana; Petherbridge Lawrence; Luke S Lambeth; William James; Venugopal Nair
Identification of an intercistronic internal ribosome entry site in a Marek's disease virus immediate-early gene.
Journal of virology 2009;83(11):5846-53.
2009: Gemma C Carter; Laura Bernstone; Dhaval Sangani; Jessica Wynter Bee; Thomas Harder; William James
HIV entry in macrophages is dependent on intact lipid rafts.
Virology 2009;386(1):192-202.
2008: Carla Cohen; Mario Forzan; Brian Sproat; Ralph Pantophlet; Ian McGowan; Dennis Burton; William James
An aptamer that neutralizes R5 strains of HIV-1 binds to core residues of gp120 in the CCR5 binding site.
Virology 2008;381(1):46-54.
2008: Karl R Karlsson; Sally Cowley; Fernando O Martinez; Michael Shaw; Stephen L Minger; William James
Homogeneous monocytes and macrophages from human embryonic stem cells following coculture-free differentiation in M-CSF and IL-3.
Experimental hematology 2008;36(9):1167-75.
2008: Remo Gerber; Kislon Voitchovsky; Clement Mitchel; Abdessamad Tahiri-Alaoui; John F Ryan; Peter J Hore; William James
Inter-oligomer interactions of the human prion protein are modulated by the polymorphism at codon 129.
Journal of molecular biology 2008;381(1):212-20.
2008: Remo Gerber; Abdessamad Tahiri-Alaoui; Peter J Hore; William James
Conformational pH dependence of intermediate states during oligomerization of the human prion protein.
Protein science : a publication of the Protein Society 2008;17(3):537-44.
2007: Remo Gerber; Abdessamad Tahiri-Alaoui; Peter J Hore; William James
Oligomerization of the human prion protein proceeds via a molten globule intermediate.
The Journal of biological chemistry 2007;282(9):6300-7.
2007: William James
Aptamers in the virologists' toolkit.
The Journal of general virology 2007;88(Pt 2):351-64.
2006: Abdessamad Tahiri-Alaoui; Valerie L Sim; Byron Caughey; William James
Molecular heterosis of prion protein beta-oligomers. A potential mechanism of human resistance to disease.
The Journal of biological chemistry 2006;281(45):34171-8.
2005: Dey Antu; Makobetsa Khati; Min Tang; Richard Wyatt; Susan M Lea; William James
An aptamer that neutralizes R5 strains of human immunodeficiency virus type 1 blocks gp120-CCR5 interaction.
Journal of virology 2005;79(21):13806-10.
2005: Dey Antu; Carla Griffiths; Susan M Lea; William James
Structural characterization of an anti-gp120 RNA aptamer that neutralizes R5 strains of HIV-1.
RNA (New York, N.Y.) 2005;11(6):873-84.
2005: Ilia Baskakov; Petra Disterer; Leonid Breydo; Michael Shaw; Andrew Gill; William James; Abdessamad Tahiri-Alaoui
The presence of valine at residue 129 in human prion protein accelerates amyloid formation.
FEBS letters 2005;579(12):2589-96.
2005: Abdessamad Tahiri-Alaoui; William James
Rapid formation of amyloid from alpha-monomeric recombinant human PrP in vitro.
Protein science : a publication of the Protein Society 2005;14(4):942-7.
2004: Alexandre Teixeira; Abdessamad Tahiri-Alaoui; Steven West; Benjamin Thomas; Aroul Ramadass; Igor Martianov; Michael J Dye; William James; Nick J Proudfoot; Alexandre Akoulitchev
Autocatalytic RNA cleavage in the human beta-globin pre-mRNA promotes transcription termination.
Nature 2004;432(7016):526-30.
2004: Abdessamad Tahiri-Alaoui; Andrew C Gill; Petra Disterer; William James
Methionine 129 variant of human prion protein oligomerizes more rapidly than the valine 129 variant: implications for disease susceptibility to Creutzfeldt-Jakob disease.
The Journal of biological chemistry 2004;279(30):31390-7.
2004: Natalie M Sayer; Matthew Cubin; Alexandre Rhie; Marc Bullock; Abdessamad Tahiri-Alaoui; William James
Structural determinants of conformationally selective, prion-binding aptamers.
The Journal of biological chemistry 2004;279(13):13102-9.
2003: Makobetsa Khati; Michael Schüman; jamal ibrahim; Quentin J Sattentau; Siamon Gordon; William James
Neutralization of infectivity of diverse R5 clinical isolates of human immunodeficiency virus type 1 by gp120-binding 2'F-RNA aptamers.
Journal of virology 2003;77(23):12692-8.
2003: Alexandre Rhie; Louise Kirby; Natalie M Sayer; Rosanna Wellesley; Petra Disterer; Ian Sylvester; Andrew Gill; James Hope; William James; Abdessamad Tahiri-Alaoui
Characterization of 2'-fluoro-RNA aptamers that bind preferentially to disease-associated conformations of prion protein and inhibit conversion.
The Journal of biological chemistry 2003;278(41):39697-705.
2003: Abdessamad Tahiri-Alaoui; Mario Bouchard; Jesús Zurdo; William James
Competing intrachain interactions regulate the formation of beta-sheet fibrils in bovine PrP peptides.
Protein science : a publication of the Protein Society 2003;12(3):600-8.
2002: Abdessamad Tahiri-Alaoui; Laura Frigotto; Nick Manville; jamal ibrahim; Pascale Romby; William James
High affinity nucleic acid aptamers for streptavidin incorporated into bi-specific capture ligands.
Nucleic acids research 2002;30(10):e45.
2002: Natalie M Sayer; jamal ibrahim; K Turner; Abdessamad Tahiri-Alaoui; William James
Structural characterization of a 2'F-RNA aptamer that binds a HIV-1 SU glycoprotein, gp120.
Biochemical and biophysical research communications 2002;293(3):924-31.
2001: William James
Nucleic acid and polypeptide aptamers: a powerful approach to ligand discovery.
Current opinion in pharmacology 2001;1(5):540-6.
2001: Makobetsa Khati; William James; Siamon Gordon
HIV-macrophage interactions at the cellular and molecular level.
Archivum immunologiae et therapiae experimentalis 2001;49(5):367-78.
1999: jamal ibrahim; P Griffin; D R Coombe; C C Rider; William James
Cell-surface heparan sulfate facilitates human immunodeficiency virus Type 1 entry into some cell lines but not primary lymphocytes.
Virus research 1999;60(2):159-69.
1998: E Kraus; William James; A Neil Barclay
Cutting edge: novel RNA ligands able to bind CD4 antigen and inhibit CD4+ T lymphocyte function.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(11):5209-12.
1998: William James
The use of ribozymes in gene therapy approaches to AIDS.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1998;144():139-46.
1997: A Al-Shamkhani; S Mallett; Marion H Brown; William James; A Neil Barclay
Affinity and kinetics of the interaction between soluble trimeric OX40 ligand, a member of the tumor necrosis factor superfamily, and its receptor OX40 on activated T cells.
The Journal of biological chemistry 1997;272(8):5275-82.
1997: J H Simon; Philip A Stumbles; N Signoret; C Somoza; Michael J Puklavec; Quentin J Sattentau; A Neil Barclay; William James
Role of CD4 epitopes outside the gp120-binding site during entry of human immunodeficiency virus type 1.
Journal of virology 1997;71(2):1476-84.
1997: William James; E Cowe
Computational approaches to the identification of ribozyme target sites.
Methods in molecular biology (Clifton, N.J.) 1997;74():17-26.
1996: A Al-Shamkhani; M L Birkeland; Michael J Puklavec; Marion H Brown; William James; A Neil Barclay
OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligand.
European journal of immunology 1996;26(8):1695-9.
1996: G Herbein; PETER ILLEI; L J Montaner; William James; Siamon Gordon
Comparison of p24 measurement by ELISA versus indicator cells for detecting residual HIV infectivity in vitro.
Journal of virological methods 1996;58(1-2):167-73.
1995: Mark Ashe; P Griffin; William James; Nick J Proudfoot
Poly(A) site selection in the HIV-1 provirus: inhibition of promoter-proximal polyadenylation by the downstream major splice donor site.
Genes & development 1995;9(23):3008-25.
1995: P B Fischer; M Collin; G B Karlsson; William James; Terry D Butters; Simon J Davis; Siamon Gordon; Raymond A Dwek; Frances M Platt
The alpha-glucosidase inhibitor N-butyldeoxynojirimycin inhibits human immunodeficiency virus entry at the level of post-CD4 binding.
Journal of virology 1995;69(9):5791-7.
1995: William James; A Al-Shamkhani
RNA enzymes as tools for gene ablation.
Current opinion in biotechnology 1995;6(1):44-9.
1994: J H Simon; G A Schockmel; PETER ILLEI; William James
A rodent cell line permissive for entry and reverse transcription of human immunodeficiency virus type 1 has a pre-integration block to productive infection.
The Journal of general virology 1994;75 ( Pt 10)():2615-23.
1994: M Collin; PETER ILLEI; William James; Siamon Gordon
Definition of the range and distribution of human immunodeficiency virus macrophage tropism using PCR-based infectivity measurements.
The Journal of general virology 1994;75 ( Pt 7)():1597-603.
1993: P Crisell; S Thompson; William James
Inhibition of HIV-1 replication by ribozymes that show poor activity in vitro.
Nucleic acids research 1993;21(22):5251-5.
1993: L J Montaner; A G Doyle; M Collin; G Herbein; PETER ILLEI; William James; A Minty; D Caput; Pascual Ferrara; Siamon Gordon
Interleukin 13 inhibits human immunodeficiency virus type 1 production in primary blood-derived human macrophages in vitro.
The Journal of experimental medicine 1993;178(2):743-7.
1993: J H Simon; C Somoza; G A Schockmel; M Collin; Simon J Davis; A F Williams; William James
A rat CD4 mutant containing the gp120-binding site mediates human immunodeficiency virus type 1 infection.
The Journal of experimental medicine 1993;177(4):949-54.
1992: William James; P Crisell; A Rhodes
Gene inhibition of HIV-1 replication. A comparative and mechanistic study.
Annals of the New York Academy of Sciences 1992;660():274-5.
1991: M Collin; William James; Siamon Gordon
Development of techniques to analyse the formation of HIV provirus in primary human macrophages.
Research in virology 1991;142(2-3):105-12.
1991: A Rhodes; William James
Inhibition of heterologous strains of HIV by antisense RNA.
AIDS (London, England) 1991;5(2):145-51.
1990: A Rhodes; William James
Inhibition of human immunodeficiency virus replication in cell culture by endogenously synthesized antisense RNA.
The Journal of general virology 1990;71 ( Pt 9)():1965-74.