FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

David Jane

Research Profile

Living Beings

Chemicals & Drugs

Anatomy

Physiology

Synaptic Transmission

Concepts & Ideas

Structure-Activity Relationship

Co-author Network

Publications

TOP 3
Arturas Volianskis; Neil Bannister; Valerie J Collett; Stephen Fitzjohn; Mark W Irvine; David E Jane; Morten S Jensen; Daniel T Monaghan; Graham L Collingridge
Different NMDA receptor subtypes mediate induction of long-term potentiation and two forms of short-term potentiation at CA1 synapses in rat hippocampus in vitro.
Daniel T Monaghan; Blaise Mathias Costa; Guangyu Fang; Mark W Irvine; David E Jane
Pharmacological modulation of NMDA receptor activity and the advent of negative and positive allosteric modulators.
Blaise Mathias Costa; Richard J Eaves; Guangyu Fang; Mark W Irvine; David E Jane; Bodo Laube; Maria Belen Mayo-Martin; Daniel T Monaghan
Structure-activity relationships for allosteric NMDA receptor inhibitors based on 2-naphthoic acid.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of David Jane (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Arturas Volianskis; Neil Bannister; Valerie J Collett; Stephen Fitzjohn; Mark W Irvine; David E Jane; Morten S Jensen; Daniel T Monaghan; Graham L Collingridge
Different NMDA receptor subtypes mediate induction of long-term potentiation and two forms of short-term potentiation at CA1 synapses in rat hippocampus in vitro.
The Journal of physiology 2013;591(Pt 4):955-72.
2012: Daniel T Monaghan; Blaise Mathias Costa; Guangyu Fang; Mark W Irvine; David E Jane
Pharmacological modulation of NMDA receptor activity and the advent of negative and positive allosteric modulators.
Neurochemistry international 2012;61(4):581-92.
2012: Blaise Mathias Costa; Richard J Eaves; Guangyu Fang; Mark W Irvine; David E Jane; Bodo Laube; Maria Belen Mayo-Martin; Daniel T Monaghan
Structure-activity relationships for allosteric NMDA receptor inhibitors based on 2-naphthoic acid.
Neuropharmacology 2012;62(4):1730-6.
2011: Gregory M Alushin; David E Jane; Mark L Mayer
Binding site and ligand flexibility revealed by high resolution crystal structures of GluK1 competitive antagonists.
Neuropharmacology 2011;60(1):126-34.
2010: Blaise Mathias Costa; Mark W Irvine; Guangyu Fang; Richard J Eaves; Marie Belen Mayo-Martin; Donald A Skifter; David E Jane; Daniel T Monaghan
A novel family of negative and positive allosteric modulators of NMDA receptors.
The Journal of pharmacology and experimental therapeutics 2010;335(3):614-21.
2010: Cédric Lamy; Samuel J Goodchild; Kate L Weatherall; David E Jane; Jean-François Liégeois; Vincent Seutin; Neil V Marrion
Allosteric block of KCa2 channels by apamin.
The Journal of biological chemistry 2010;285(35):27067-77.
2010: Kate L Weatherall; Samuel J Goodchild; David E Jane; Neil V Marrion
Small conductance calcium-activated potassium channels: from structure to function.
Progress in neurobiology 2010;91(3):242-55.
2009: Charalambos Sigalas; Maria Belen Mayo-Martin; David E Jane; Rebecca Sitsapesan
Ca2+-calmodulin increases RyR2 open probability yet reduces ryanoid association with RyR2.
Biophysical journal 2009;97(7):1907-16.
2009: Robert Nisticò; Sheila Dargan; Stephen Fitzjohn; David Lodge; David E Jane; Graham Collingridge; Zuner A Bortolotto
GLUK1 receptor antagonists and hippocampal mossy fiber function.
International review of neurobiology 2009;85():13-27.
2009: Sheila L Dargan; Vernon R J Clarke; Gregory M Alushin; John L Sherwood; Robert Nisticò; Zuner A Bortolotto; Ann M Ogden; David Bleakman; Andrew J Doherty; David Lodge; Mark L Mayer; Stephen Fitzjohn; David E Jane; Graham Collingridge
ACET is a highly potent and specific kainate receptor antagonist: characterisation and effects on hippocampal mossy fibre function.
Neuropharmacology 2009;56(1):121-30.
2008: S L C Brothwell; J L Barber; Daniel T Monaghan; David E Jane; A J Gibb; S Jones
NR2B- and NR2D-containing synaptic NMDA receptors in developing rat substantia nigra pars compacta dopaminergic neurones.
The Journal of physiology 2008;586(3):739-50.
2007: Nigel P Dolman; Julia C A More; Andrew Alt; Jody L Knauss; Olli Pentikäinen; Carla R Glasser; David Bleakman; Mark L Mayer; Graham Collingridge; David E Jane
Synthesis and pharmacological characterization of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonists.
Journal of medicinal chemistry 2007;50(7):1558-70.
2007: John R Huxter; Larissa E Zinyuk; Eva v L Roloff; Vernon R J Clarke; Nigel P Dolman; Julia C A More; David E Jane; Graham Collingridge; Robert U Muller
Inhibition of kainate receptors reduces the frequency of hippocampal theta oscillations.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(9):2212-23.
2006: Nigel P Dolman; Julia C A More; Andrew Alt; Jody L Knauss; Helen M Troop; David Bleakman; Graham Collingridge; David E Jane
Structure-activity relationship studies on N3-substituted willardiine derivatives acting as AMPA or kainate receptor antagonists.
Journal of medicinal chemistry 2006;49(8):2579-92.
2006: Gareth R I Barker; E Clea Warburton; Timothy Koder; Nigel P Dolman; Julia C A More; John P Aggleton; Zafar I Bashir; Yves P Auberson; David E Jane; Malcolm W Brown
The different effects on recognition memory of perirhinal kainate and NMDA glutamate receptor antagonism: implications for underlying plasticity mechanisms.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(13):3561-6.
2006: Mark L Mayer; Alokesh Ghosal; Nigel P Dolman; David E Jane
Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(11):2852-61.
2006: Jeffrey C Watkins; David E Jane
The glutamate story.
British journal of pharmacology 2006;147 Suppl 1():S100-8.
2005: Nigel P Dolman; Helen M Troop; Julia C A More; Andrew Alt; Jody L Knauss; Robert Nistico; Samantha Jack; Richard M Morley; Zuner A Bortolotto; Peter J Roberts; David Bleakman; Graham Collingridge; David E Jane
Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors.
Journal of medicinal chemistry 2005;48(24):7867-81.
2005: Zuner A Bortolotto; Robert Nistico; Julia C A More; David E Jane; Graham Collingridge
Kainate receptors and mossy fiber LTP.
Neurotoxicology 2005;26(5):769-77.
2005: Leo Kinarsky; Bihua Feng; Donald A Skifter; Richard M Morley; Simon Sherman; David E Jane; Daniel T Monaghan
Identification of subunit- and antagonist-specific amino acid residues in the N-Methyl-D-aspartate receptor glutamate-binding pocket.
The Journal of pharmacology and experimental therapeutics 2005;313(3):1066-74.
2005: Richard M Morley; Heong-Wai Tse; Bihua Feng; Jacqueline C Miller; Daniel T Monaghan; David E Jane
Synthesis and pharmacology of N1-substituted piperazine-2,3-dicarboxylic acid derivatives acting as NMDA receptor antagonists.
Journal of medicinal chemistry 2005;48(7):2627-37.
2005: Bihua Feng; Richard M Morley; David E Jane; Daniel T Monaghan
The effect of competitive antagonist chain length on NMDA receptor subunit selectivity.
Neuropharmacology 2005;48(3):354-9.
2004: Julia C A More; Robert Nistico; Nigel P Dolman; Vernon R J Clarke; Andrew Alt; Ann Marie Ogden; Floris P Buelens; Helen M Troop; Eve E Kelland; Fabio Pilato; David Bleakman; Zuner A Bortolotto; Graham Collingridge; David E Jane
Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist.
Neuropharmacology 2004;47(1):46-64.
2004: Stuart J Mundell; Giordano Pula; Julia C A More; David E Jane; Peter J Roberts; Eamonn Kelly
Activation of cyclic AMP-dependent protein kinase inhibits the desensitization and internalization of metabotropic glutamate receptors 1a and 1b.
Molecular pharmacology 2004;65(6):1507-16.
2004: Bihua Feng; Heong-Wai Tse; Donald A Skifter; Richard M Morley; David E Jane; Daniel T Monaghan
Structure-activity analysis of a novel NR2C/NR2D-preferring NMDA receptor antagonist: 1-(phenanthrene-2-carbonyl) piperazine-2,3-dicarboxylic acid.
British journal of pharmacology 2004;141(3):508-16.
2003: Jacqueline C Miller; Patrick A Howson; Stuart Conway; Richard V Williams; Barry P Clark; David E Jane
Phenylglycine derivatives as antagonists of group III metabotropic glutamate receptors expressed on neonatal rat primary afferent terminals.
British journal of pharmacology 2003;139(8):1523-31.
2003: Patrick A Howson; David E Jane
Actions of LY341495 on metabotropic glutamate receptor-mediated responses in the neonatal rat spinal cord.
British journal of pharmacology 2003;139(1):147-55.
2003: Julia C A More; Helen M Troop; Nigel P Dolman; David E Jane
Structural requirements for novel willardiine derivatives acting as AMPA and kainate receptor antagonists.
British journal of pharmacology 2003;138(6):1093-100.
2002: Julia C A More; Helen M Troop; David E Jane
The novel antagonist 3-CBW discriminates between kainate receptors expressed on neonatal rat motoneurones and those on dorsal root C-fibres.
British journal of pharmacology 2002;137(7):1125-33.
2001: Stuart Conway; Jacqueline C Miller; Patrick A Howson; B P Clark; David E Jane
Synthesis of phenylglycine derivatives as potent and selective antagonists of group III metabotropic glutamate receptors.
Bioorganic & medicinal chemistry letters 2001;11(6):777-80.
2001: NK Thomas; Rebecca A Wright; Patrick A Howson; Ann E Kingston; Darryle D Schoepp; David E Jane
(S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord.
Neuropharmacology 2001;40(3):311-8.
2000: S Hrabetova; Peter Serrano; Nancy Blace; Heong-Wai Tse; Donald A Skifter; David E Jane; Daniel T Monaghan; Todd Charlton Sacktor
Distinct NMDA receptor subpopulations contribute to long-term potentiation and long-term depression induction.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(12):RC81.
2000: JM Christie; David E Jane; Daniel T Monaghan
Native N-methyl-D-aspartate receptors containing NR2A and NR2B subunits have pharmacologically distinct competitive antagonist binding sites.
The Journal of pharmacology and experimental therapeutics 2000;292(3):1169-74.
1999: Andrew J Doherty; Graham Collingridge; David E Jane
Antagonist activity of alpha-substituted 4-carboxyphenylglycine analogues at group I metabotropic glutamate receptors expressed in CHO cells.
British journal of pharmacology 1999;126(1):205-10.
1998: NK Thomas; L M Hawkins; Jacqueline C Miller; Helen M Troop; Peter J Roberts; David E Jane
Pharmacological differentiation of kainate receptors on neonatal rat spinal motoneurones and dorsal roots.
Neuropharmacology 1998;37(10-11):1223-37.
1998: J C Brown; Heong-Wai Tse; Donald A Skifter; JM Christie; VJ Andaloro; M C Kemp; Jeffrey C Watkins; David E Jane; Daniel T Monaghan
[3H]homoquinolinate binds to a subpopulation of NMDA receptors and to a novel binding site.
Journal of neurochemistry 1998;71(4):1464-70.
1998: S A Hussain; David E Jane; Peter V Taberner
Lack of inhibition of human plasma cholinesterase and red cell acetylcholinesterase by antimony compounds including stibine.
Human & experimental toxicology 1998;17(3):140-3.
1997: NK Thomas; P Clayton; David E Jane
Dicarboxyphenylglycines antagonize AMPA- but not kainate-induced depolarizations in neonatal rat motoneurones.
European journal of pharmacology 1997;338(2):111-6.
1997: Mary J Palmer; A J Irving; Guy R Seabrook; David E Jane; Graham Collingridge
The group I mGlu receptor agonist DHPG induces a novel form of LTD in the CA1 region of the hippocampus.
Neuropharmacology 1997;36(11-12):1517-32.
1997: David E Jane; KH Hoo; Rajender K Kamboj; Michelle Deverill; David Bleakman; Allan Mandelzys
Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes.
Journal of medicinal chemistry 1997;40(22):3645-50.
1997: Claire Wilson; Judith A K Howard; David E Jane; D C Sunter; Jeffrey C Watkins
Absolute configuration of (+)-alpha-methyl-4-carboxyphenylglycine (MCPG), a metabotropic glutamate receptor antagonist.
Acta crystallographica. Section C, Crystal structure communications 1997;53 ( Pt 7)():909-11.
1997: C Q Cao; Heong-Wai Tse; David E Jane; RH Evans; P M Headley
Metabotropic glutamate receptor antagonists, like GABA(B) antagonists, potentiate dorsal root-evoked excitatory synaptic transmission at neonatal rat spinal motoneurons in vitro.
Neuroscience 1997;78(1):243-50.
1997: C Q Cao; Heong-Wai Tse; David E Jane; RH Evans; P M Headley
Antagonism of mGlu receptors and potentiation of EPSCs at rat spinal motoneurones in vitro.
Neuropharmacology 1997;36(3):313-8.
1997: Andrew J Doherty; Mary J Palmer; Jeremy M Henley; Graham Collingridge; David E Jane
(RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but no mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus.
Neuropharmacology 1997;36(2):265-7.
1997: Wallace B Thoreson; J Gottesman; David E Jane; Heong-Wai Tse; Jeffrey C Watkins; R F Miller
Two phenylglycine derivatives antagonize responses to L-AP4 in ON bipolar cells of the amphibian retina.
Neuropharmacology 1997;36(1):13-20.
1996: David E Jane; D J Chalmers; J A Howard; Ian C Kilpatrick; D C Sunter; G A Thompson; P M Udvarhelyi; C Wilson; Jeffrey C Watkins
Diastereoselective synthesis of all four isomers of 3-(4-chlorophenyl) glutamic acid: identification of the isomers responsible for the potentiation of L-homocysteic acid-evoked depolarizations in neonatal rat motoneurons.
Journal of medicinal chemistry 1996;39(24):4738-43.
1996: Nick J Toms; David E Jane; M C Kemp; J S Bedingfield; Peter J Roberts
The effects of (RS)-alpha-cyclopropyl-4-phosphonophenylglycine ((RS)-CPPG), a potent and selective metabotropic glutamate receptor antagonist.
British journal of pharmacology 1996;119(5):851-4.
1996: M C Kemp; David E Jane; Heong-Wai Tse; Peter J Roberts
Agonists of cyclic AMP-coupled metabotropic glutamate receptors in adult rat cortical slices.
European journal of pharmacology 1996;309(1):79-85.
1996: J S Bedingfield; David E Jane; M C Kemp; Nick J Toms; Peter J Roberts
Novel potent selective phenylglycine antagonists of metabotropic glutamate receptors.
European journal of pharmacology 1996;309(1):71-8.
1996: N K Thomas; David E Jane; Heong-Wai Tse; Jeffrey C Watkins
alpha-Methyl derivatives of serine-O-phosphate as novel, selective competitive metabotropic glutamate receptor antagonists.
Neuropharmacology 1996;35(6):637-42.
1996: N Sekiyama; Yukako Hayashi; Shigetada Nakanishi; David E Jane; Heong-Wai Tse; E F Birse; Jeffrey C Watkins
Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes.
British journal of pharmacology 1996;117(7):1493-503.
1996: T J Bushell; David E Jane; Heong-Wai Tse; Jeffrey C Watkins; J Garthwaite; Graham Collingridge
Pharmacological antagonism of the actions of group II and III mGluR agonists in the lateral perforant path of rat hippocampal slices.
British journal of pharmacology 1996;117(7):1457-62.
1996: David E Jane; N K Thomas; Heong-Wai Tse; Jeffrey C Watkins
Potent antagonists at the L-AP4- and (1S,3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cord.
Neuropharmacology 1996;35(8):1029-35.
1995: D J Chalmers; David E Jane; D C Sunter; G A Thompson; P M Udvarhelyi; Ian C Kilpatrick; Jeffrey C Watkins
Differential actions of 3-(4-chlorophenyl) glutamic acid stereoisomers and L-trans-pyrrolidine-2,4-dicarboxylic acid upon L-homocysteic acid- and L-glutamic acid-induced responses from rat spinal motoneurones.
Neuropharmacology 1995;34(12):1589-95.
1995: J S Bedingfield; M C Kemp; David E Jane; Heong-Wai Tse; Peter J Roberts; Jeffrey C Watkins
Structure-activity relationships for a series of phenylglycine derivatives acting at metabotropic glutamate receptors (mGluRs).
British journal of pharmacology 1995;116(8):3323-9.
1995: Nick J Toms; David E Jane; Heong-Wai Tse; Peter J Roberts
Characterization of metabotropic glutamate receptor-stimulated phosphoinositide hydrolysis in rat cultured cerebellar granule cells.
British journal of pharmacology 1995;116(7):2824-7.
1995: L M Hawkins; K M Beaver; David E Jane; P M Taylor; D C Sunter; Peter J Roberts
Characterization of the pharmacology and regional distribution of (S)-[3H]-5-fluorowillardiine binding in rat brain.
British journal of pharmacology 1995;116(3):2033-9.
1995: Ceri H Davies; Vernon R J Clarke; David E Jane; Graham Collingridge
Pharmacology of postsynaptic metabotropic glutamate receptors in rat hippocampal CA1 pyramidal neurones.
British journal of pharmacology 1995;116(2):1859-69.
1995: M Vignes; Vernon R J Clarke; Ceri H Davies; A Chambers; David E Jane; Jeffrey C Watkins; Graham Collingridge
Pharmacological evidence for an involvement of group II and group III mGluRs in the presynaptic regulation of excitatory synaptic responses in the CA1 region of rat hippocampal slices.
Neuropharmacology 1995;34(8):973-82.
1995: David E Jane; K Pittaway; D C Sunter; N K Thomas; Jeffrey C Watkins
New phenylglycine derivatives with potent and selective antagonist activity at presynaptic glutamate receptors in neonatal rat spinal cord.
Neuropharmacology 1995;34(8):851-6.
1995: L M Hawkins; K M Beaver; David E Jane; P M Taylor; D C Sunter; Peter J Roberts
Binding of the new radioligand (S)-[3H]AMPA to rat brain synaptic membranes: effects of a series of structural analogues of the non-NMDA receptor agonist willardiine.
Neuropharmacology 1995;34(4):405-10.
1995: T J Bushell; David E Jane; Heong-Wai Tse; Jeffrey C Watkins; Ceri H Davies; J Garthwaite; Graham Collingridge
Antagonism of the synaptic depressant actions of L-AP4 in the lateral perforant path by MAP4.
Neuropharmacology 1995;34(2):239-41.
1994: Y Gaoni; Astrid G Chapman; N Parvez; P C Pook; David E Jane; Jeffrey C Watkins
Synthesis, NMDA receptor antagonist activity, and anticonvulsant action of 1-aminocyclobutanecarboxylic acid derivatives.
Journal of medicinal chemistry 1994;37(25):4288-96.
1994: David E Jane; P L Jones; P C Pook; Heong-Wai Tse; Jeffrey C Watkins
Actions of two new antagonists showing selectivity for different sub-types of metabotropic glutamate receptor in the neonatal rat spinal cord.
British journal of pharmacology 1994;112(3):809-16.
1994: Yukako Hayashi; N Sekiyama; Shigetada Nakanishi; David E Jane; D C Sunter; E F Birse; P M Udvarhelyi; Jeffrey C Watkins
Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor subtypes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1994;14(5 Pt 2):3370-7.
1994: M Kemp; P Roberts; P Pook; David E Jane; A Jones; P Jones; D Sunter; P Udvarhelyi; J Watkins
Antagonism of presynaptically mediated depressant responses and cyclic AMP-coupled metabotropic glutamate receptors.
European journal of pharmacology 1994;266(2):187-92.
1993: Zafar I Bashir; David E Jane; D C Sunter; Jeffrey C Watkins; Graham Collingridge
Metabotropic glutamate receptors contribute to the induction of long-term depression in the CA1 region of the hippocampus.
European journal of pharmacology 1993;239(1-3):265-6.
1993: David E Jane; P L Jones; P C Pook; Thomas E Salt; D C Sunter; Jeffrey C Watkins
Stereospecific antagonism by (+)-alpha-methyl-4-carboxyphenylglycine (MCPG) of (1S,3R)-ACPD-induced effects in neonatal rat motoneurones and rat thalamic neurones.
Neuropharmacology 1993;32(7):725-7.
1993: Zafar I Bashir; Zuner A Bortolotto; Ceri H Davies; N Berretta; A J Irving; A J Seal; Jeremy M Henley; David E Jane; Jeffrey C Watkins; Graham Collingridge
Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptors.
Nature 1993;363(6427):347-50.
1993: E F Birse; S A Eaton; David E Jane; P L Jones; R H Porter; P C Pook; D C Sunter; P M Udvarhelyi; B Wharton; Peter J Roberts
Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system.
Neuroscience 1993;52(3):481-8.
1993: S A Eaton; David E Jane; P L Jones; R H Porter; P C Pook; D C Sunter; P M Udvarhelyi; Peter J Roberts; Thomas E Salt; Jeffrey C Watkins
Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine and (RS)-alpha-methyl-4-carboxyphenylglycine.
European journal of pharmacology 1993;244(2):195-7.
1992: R H Porter; Peter J Roberts; David E Jane; J C Watkins
(S)-homoquisqualate: a potent agonist at the glutamate metabotropic receptor.
British journal of pharmacology 1992;106(3):509-10.