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Nathalie Janel

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Asma Tlili; Sirine Mohamed; Jean-Louis Paul; Nicole Belin; Linh-Chi Bui; Julien Dairou; Bart De Geest; Leanne de Koning; jean maurice delabar; Thierry Dubois; Véronique Ducros; Frank Jacobs; Nathalie Janel
Hepatocyte-specific Dyrk1a gene transfer rescues plasma apolipoprotein A-I levels and aortic Akt/GSK3 pathways in hyperhomocysteinemic mice.
Chris Planque; Clémentine Ripoll; Christophe Noll; Linh-Chi Bui; Julien Dairou; jean maurice delabar; Fayçal Guedj; Nathalie Janel
Mice Deficient in Cystathionine Beta Synthase Display Increased Dyrk1A and SAHH Activities in Brain.
Christophe Noll; Jean-Louis Paul; Julie Lameth; Nathalie Janel
Effect of catechin/epicatechin dietary intake on endothelial dysfunction biomarkers and proinflammatory cytokines in aorta of hyperhomocysteinemic mice.

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All Publications

2013: Asma Tlili; Sirine Mohamed; Jean-Louis Paul; Nicole Belin; Linh-Chi Bui; Julien Dairou; Bart De Geest; Leanne de Koning; jean maurice delabar; Thierry Dubois; Véronique Ducros; Frank Jacobs; Nathalie Janel
Hepatocyte-specific Dyrk1a gene transfer rescues plasma apolipoprotein A-I levels and aortic Akt/GSK3 pathways in hyperhomocysteinemic mice.
Biochimica et biophysica acta 2013;1832(6):718-28.
2013: Chris Planque; Clémentine Ripoll; Christophe Noll; Linh-Chi Bui; Julien Dairou; jean maurice delabar; Fayçal Guedj; Nathalie Janel
Mice Deficient in Cystathionine Beta Synthase Display Increased Dyrk1A and SAHH Activities in Brain.
Journal of molecular neuroscience : MN 2013;50(1):1-6.
2013: Christophe Noll; Jean-Louis Paul; Julie Lameth; Nathalie Janel
Effect of catechin/epicatechin dietary intake on endothelial dysfunction biomarkers and proinflammatory cytokines in aorta of hyperhomocysteinemic mice.
European journal of nutrition 2013;52(3):1243-50.
2013: Sabiha Abekhoukh; jean maurice delabar; Jean-Louis Paul; Chris Planque; Clémentine Ripoll; Paulina Urbaniak; Nathalie Janel
Dyrk1A, a serine/threonine kinase, is involved in ERK and Akt activation in the brain of hyperhomocysteinemic mice.
Molecular neurobiology 2013;47(1):105-16.
2012: Asma Tlili; Renaud Touraine; Bregje van Bon; Björn Menten; Marie-Claude Potier; Clémentine Ripoll; Anne Ronan; Samantha Stora; Stylianos E Antonarakis; Anne Badel; Eva Benabou; Henri Bléhaut; Nele Bockaert; Dominique Campion; Bert de Vries; jean maurice delabar; Joseph Gecz; Yann Grattau; Alexander Hoischen; Nathalie Janel
BDNF and DYRK1A are variable and inversely correlated in lymphoblastoid cell lines from Down syndrome patients.
Molecular neurobiology 2012;46(2):297-303.
2012: Christophe Noll; Jean-Louis Paul; Clémentine Ripoll; Asma Tlili; jean maurice delabar; Ludovic Mallet; Nathalie Janel
Dyrk1a activates antioxidant NQO1 expression through an ERK1/2-Nrf2 dependent mechanism.
Molecular genetics and metabolism 2012;105(3):484-8.
2011: Marie-Hélène Giroix; Philippe A Halban; Sophie Calderari; M Cornut; Josiane Coulaud; Jan A Ehses; Jean-Claude Irminger; Nathalie Janel; Nadim Kassis; Micheline Kergoat; G Lacraz; Christophe Noll; Jean-Louis Paul; Fabien Schmidlin; Françoise Homo-Delarche
Hypercholesterolaemia, signs of islet microangiopathy and altered angiogenesis precede onset of type 2 diabetes in the Goto-Kakizaki (GK) rat.
Diabetologia 2011;54(9):2451-62.
2011: Christophe Noll; Jean-Louis Paul; Emile Petit; Chris Planque; Lamia Raaf; Fernando Rodrigues-Lima; Jane-Lise Samuel; Lise Secardin; Ludovic Benard; Julien Dairou; Claude Delcayre; Nathalie Janel
Protection and reversal of hepatic fibrosis by red wine polyphenols in hyperhomocysteinemic mice.
The Journal of nutritional biochemistry 2011;22(9):856-64.
2011: Christophe Noll; Jean-Louis Paul; Clémentine Ripoll; Fernando Rodrigues-Lima; Julien Dairou; jean maurice delabar; Jean-Marie Dupret; Nathalie Janel
Effect of red wine polyphenol dietary supplementation on two phase II enzymes in liver of hyperhomocysteinemic mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2011;49(8):1764-9.
2011: Christophe Noll; Gregory Lacraz; Jan A Ehses; Josiane Coulaud; Danièle Bailbe; Jean-Louis Paul; Bernard Portha; Françoise Homo-Delarche; Nathalie Janel
Early reduction of circulating homocysteine levels in Goto-Kakizaki rat, a spontaneous nonobese model of type 2 diabetes.
Biochimica et biophysica acta 2011;1812(6):699-702.
2011: Lamia Raaf; Christophe Noll; Mohamed El Hadi Cherifi; Jane-Lise Samuel; Claude Delcayre; jean maurice delabar; Yasmina Benazzoug; Nathalie Janel
Myocardial fibrosis and TGFB expression in hyperhomocysteinemic rats.
Molecular and cellular biochemistry 2011;347(1-2):63-70.
2010: Nilusha Ragunathan; Julien Dairou; Elodie Sanfins; Florent Busi; Christophe Noll; Nathalie Janel; Jean-Marie Dupret; Fernando Rodrigues-Lima
Cadmium alters the biotransformation of carcinogenic aromatic amines by arylamine N-acetyltransferase xenobiotic-metabolizing enzymes: molecular, cellular, and in vivo studies.
Environmental health perspectives 2010;118(12):1685-91.
2010: Lamia Raaf; Christophe Noll; Mohamed Cherifi; Yasmina Benazzoug; jean maurice delabar; Nathalie Janel
Hyperhomocysteinemia-induced Dyrk1a downregulation results in cardiomyocyte hypertrophy in rats.
International journal of cardiology 2010;145(2):306-7.
2010: Christophe Noll; Smail Messaoudi; Paul Milliez; Jane-Lise Samuel; Claude Delcayre; Nathalie Janel
Eplerenone administration has beneficial effect on hepatic paraoxonase 1 activity in diabetic mice.
Atherosclerosis 2010;208(1):26-7.
2009: Christophe Noll; Julien Hamelet; Ewelina Matulewicz; Jean-Louis Paul; jean maurice delabar; Nathalie Janel
Effects of red wine polyphenolic compounds on paraoxonase-1 and lectin-like oxidized low-density lipoprotein receptor-1 in hyperhomocysteinemic mice.
The Journal of nutritional biochemistry 2009;20(8):586-96.
2009: Julien Hamelet; Jean-Pierre Couty; Anne-Marie Crain; Christophe Noll; Catherine Postic; Jean-Louis Paul; jean maurice delabar; Mireille Viguier; Nathalie Janel
Calpain activation is required for homocysteine-mediated hepatic degradation of inhibitor I kappa B alpha.
Molecular genetics and metabolism 2009;97(2):114-20.
2009: Julien Hamelet; Christophe Noll; Clémentine Ripoll; Jean-Louis Paul; Nathalie Janel; jean maurice delabar
Effect of hyperhomocysteinemia on the protein kinase DYRK1A in liver of mice.
Biochemical and biophysical research communications 2009;378(3):673-7.
2009: Christophe Noll; Chris Planque; Clémentine Ripoll; Fayçal Guedj; Anna Diez; Véronique Ducros; Nicole Belin; Arnaud Duchon; Jean-Louis Paul; Anne Badel; Bénédicte de Freminville; Yann Grattau; Henri Bléhaut; Yann Herault; Nathalie Janel; jean maurice delabar
DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinase.
PloS one 2009;4(10):e7540.
2009: Grégory Lacraz; Marie-Hélène Giroix; Nadim Kassis; Josiane Coulaud; Anne Galinier; Christophe Noll; Mélanie Cornut; Fabien Schmidlin; Jean-Louis Paul; Nathalie Janel; Jean-Claude Irminger; Micheline Kergoat; Bernard Portha; Marc Y Donath; Jan A Ehses; Françoise Homo-Delarche
Islet endothelial activation and oxidative stress gene expression is reduced by IL-1Ra treatment in the type 2 diabetic GK rat.
PloS one 2009;4(9):e6963.
2009: Christophe Noll; Julien Hamelet; Véronique Ducros; Nicole Belin; Jean-Louis Paul; jean maurice delabar; Nathalie Janel
Resveratrol supplementation worsen the dysregulation of genes involved in hepatic lipid homeostasis observed in hyperhomocysteinemic mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2009;47(1):230-6.
2008: Julien Hamelet; Virginie Seltzer; Emile Petit; Christophe Noll; Karine Andreau; jean maurice delabar; Nathalie Janel
Cystathionine beta synthase deficiency induces catalase-mediated hydrogen peroxide detoxification in mice liver.
Biochimica et biophysica acta 2008;1782(7-8):482-8.
2008: Nilusha Ragunathan; Julien Dairou; Benjamin Pluvinage; Marta Martins; Emile Petit; Nathalie Janel; Jean-Marie Dupret; Fernando Rodrigues-Lima
Identification of the xenobiotic-metabolizing enzyme arylamine N-acetyltransferase 1 as a new target of cisplatin in breast cancer cells: molecular and cellular mechanisms of inhibition.
Molecular pharmacology 2008;73(6):1761-8.
2007: Julien Hamelet; Emilie Aït Yahya-Graison; E Matulewicz; Christophe Noll; A Badel-Chagnon; A-C Camproux; Karine Demuth; Jean-Louis Paul; Jean-Maurice Delabar; Nathalie Janel
Homocysteine threshold value based on cystathionine beta synthase and paraoxonase 1 activities in mice.
European journal of clinical investigation 2007;37(12):933-8.
2007: Julien Hamelet; Nicole Maurin; Romain Fulchiron; Jean-Maurice Delabar; Nathalie Janel
Mice lacking cystathionine beta synthase have lung fibrosis and air space enlargement.
Experimental and molecular pathology 2007;83(2):249-53.
2007: Jean-Marc Alberto; Julien Hamelet; Christophe Noll; Sébastien Blaise; Jean-Pierre Bronowicki; Jean-Louis Guéant; Jean-Maurice Delabar; Nathalie Janel
Mice deficient in cystathionine beta synthase display altered homocysteine remethylation pathway.
Molecular genetics and metabolism 2007;91(4):396-8.
2007: Martine Cohen-Salmon; Béatrice Regnault; Nadège Cayet; Dorothée Caille; Karine Demuth; Jean-Pierre Hardelin; Nathalie Janel; Paolo Meda; Christine Petit
Connexin30 deficiency causes instrastrial fluid-blood barrier disruption within the cochlear stria vascularis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(15):6229-34.
2007: Julien Hamelet; Karine Demuth; Julien Dairou; Aurélie Ledru; Jean-Louis Paul; Jean-Marie Dupret; Jean-Maurice Delabar; Fernando Rodrigues-Lima; Nathalie Janel
Effects of catechin on homocysteine metabolism in hyperhomocysteinemic mice.
Biochemical and biophysical research communications 2007;355(1):221-7.
2007: Julien Hamelet; Karine Demuth; Jean-Louis Paul; Jean-Maurice Delabar; Nathalie Janel
Hyperhomocysteinemia due to cystathionine beta synthase deficiency induces dysregulation of genes involved in hepatic lipid homeostasis in mice.
Journal of hepatology 2007;46(1):151-9.
2006: Vasiliki Likogianni; Nathalie Janel; Aurélie Ledru; Philippe Beaune; Jean-Louis Paul; Karine Demuth
Thiol compounds metabolism in mice, rats and humans: comparative study and potential explanation of rodents protection against vascular diseases.
Clinica chimica acta; international journal of clinical chemistry 2006;372(1-2):140-6.
2006: Nathalie Janel; Olivier Christophe; Emilie Aït Yahya-Graison; Julien Hamelet; Evelyne Paly; Marguerite Prieur; Anne-Lise Delezoïde; Jean-Maurice Delabar
Paraoxonase-1 expression is up-regulated in Down syndrome fetal liver.
Biochemical and biophysical research communications 2006;346(4):1303-6.
2006: Julien Hamelet; Karine Demuth; Jean-Maurice Delabar; Nathalie Janel
Inhibition of extracellular signal-regulated kinase in liver of hyperhomocysteinemic mice.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(7):e126-7.
2005: Dominique Santiard-Baron; Joelle Aupetit; Nathalie Janel
Plasma homocysteine levels are not increased in murine models of Alzheimer's disease.
Neuroscience research 2005;53(4):447-9.
2005: Karine Robert; Johnny Nehmé; Emmanuel Bourdon; Gérard Pivert; Bertrand Friguet; Claude Delcayre; Jean-Maurice Delabar; Nathalie Janel
Cystathionine beta synthase deficiency promotes oxidative stress, fibrosis, and steatosis in mice liver.
Gastroenterology 2005;128(5):1405-15.
2005: Diane Damotte; Karine Robert; Julien Hamelet; Nathalie Janel; Jean-François Chassé
Homocysteine is not detected in normal human vessel walls.
Atherosclerosis 2005;179(1):211-2.
2005: Karine Robert; Christiane Pagès; Aurélie Ledru; Jean-Maurice Delabar; Jocelyne Caboche; Nathalie Janel
Regulation of extracellular signal-regulated kinase by homocysteine in hippocampus.
Neuroscience 2005;133(4):925-35.
2005: Karine Robert; Nicole Maurin; Catherine Vayssettes; Nathalie Siauve; Nathalie Janel
Cystathionine beta synthase deficiency affects mouse endochondral ossification.
The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology 2005;282(1):1-7.
2004: Karine Robert; Nicole Maurin; Aurélie Ledru; Jean-Maurice Delabar; Nathalie Janel
Hyperkeratosis in cystathionine beta synthase-deficient mice: an animal model of hyperhomocysteinemia.
The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology 2004;280(2):1072-6.
2004: Nathalie Janel; Karine Robert; Caroline Chabert; Aurélie Ledru; Cédric Gouédard; Robert Barouki; Jean-Maurice Delabar; Jean-François Chassé
Mouse liver paraoxonase-1 gene expression is downregulated in hyperhomocysteinemia.
Thrombosis and haemostasis 2004;92(1):221-2.
2004: Karine Robert; Dominique Santiard-Baron; Jean-François Chassé; Evelyne Paly; Joelle Aupetit; Pierre Kamoun; Jacqueline London; Nathalie Janel
The neuronal SAPK/JNK pathway is altered in a murine model of hyperhomocysteinemia.
Journal of neurochemistry 2004;89(1):33-43.
2003: Karine Robert; Jean-François Chassé; Dominique Santiard-Baron; Catherine Vayssettes; Allel Chabli; Joelle Aupetit; Nobuyo Maeda; Pierre Kamoun; Jacqueline London; Nathalie Janel
Altered gene expression in liver from a murine model of hyperhomocysteinemia.
The Journal of biological chemistry 2003;278(34):31504-11.
2003: Cécile V Denis; Virginie Terraube; Karine Robert; Nathalie Janel
Elevated plasma von Willebrand factor in a murine model of severe hyperhomocysteinemia.
Thrombosis and haemostasis 2003;90(2):362-4.
2003: Karine Robert; François Vialard; Eric Thiery; Kiyoko Toyama; Pierre-Marie Sinet; Nathalie Janel; Jacqueline London
Expression of the cystathionine beta synthase (CBS) gene during mouse development and immunolocalization in adult brain.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2003;51(3):363-71.