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Charles Janeway

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Margaret S Bynoe; Christophe Viret; Richard A Flavell; Charles A Janeway
T cells from epicutaneously immunized mice are prone to T cell receptor revision.
David W Scheifele; Scott Halperin; Barbara Law; Arlene King; Scott Halperin; Robert Morris; Charles A Janeway; Pierre Déry; Marc Lebel; Dorothy Moore; Nicole Le Saux; E Lee Ford-Jones; Ben Tan; Taj Jadavji; Wendy Vaudry; Wikke Walop; Joanne Embree; John Waters
Invasive Haemophilus influenzae type b infections in vaccinated and unvaccinated children in Canada, 2001-2003.
Anne Isabelle Munier; Ruslan Medzhitov; Charles A Janeway; Daniel Doucet; Maria Capovilla; Marie Lagueux
graal: a Drosophila gene coding for several mosaic serine proteases.

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All Publications

2005: Margaret S Bynoe; Christophe Viret; Richard A Flavell; Charles A Janeway
T cells from epicutaneously immunized mice are prone to T cell receptor revision.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(8):2898-903.
2005: David W Scheifele; Scott Halperin; Barbara Law; Arlene King; Scott Halperin; Robert Morris; Charles A Janeway; Pierre Déry; Marc Lebel; Dorothy Moore; Nicole Le Saux; E Lee Ford-Jones; Ben Tan; Taj Jadavji; Wendy Vaudry; Wikke Walop; Joanne Embree; John Waters
Invasive Haemophilus influenzae type b infections in vaccinated and unvaccinated children in Canada, 2001-2003.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 2005;172(1):53-6.
2004: Anne Isabelle Munier; Ruslan Medzhitov; Charles A Janeway; Daniel Doucet; Maria Capovilla; Marie Lagueux
graal: a Drosophila gene coding for several mosaic serine proteases.
Insect biochemistry and molecular biology 2004;34(10):1025-35.
2004: F Susan Wong; Li Wen; Michelle Tang; Murugappan Ramanathan; Irene Visintin; Joanne Daugherty; Lynn G Hannum; Charles A Janeway; Mark J Shlomchik
Investigation of the role of B-cells in type 1 diabetes in the NOD mouse.
Diabetes 2004;53(10):2581-7.
2003: Margaret S Bynoe; J Tori Evans; Christophe Viret; Charles A Janeway
Epicutaneous immunization with autoantigenic peptides induces T suppressor cells that prevent experimental allergic encephalomyelitis.
Immunity 2003;19(3):317-28.
2003: Christophe Viret; Xin He; Charles A Janeway
Altered positive selection due to corecognition of floppy peptide/MHC II conformers supports an integrative model of thymic selection.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(9):5354-9.
2003: Julie M. Blander; Derek B Sant'Angelo; Daniela Metz; Sang-Won Kim; Richard A Flavell; Kim Bottomly; Charles A Janeway
A pool of central memory-like CD4 T cells contains effector memory precursors.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(6):2940-8.
2003: Gobardhan Das; Charles A Janeway
MHC specificity of iIELs.
Trends in immunology 2003;24(2):88-93.
2003: Christophe Viret; Charles A Janeway
Self-specific MHC class II-restricted CD4-CD8- T cells that escape deletion and lack regulatory activity.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(1):201-9.
2002: Anne-Isabelle Munier; Daniel Doucet; Emmanuel Perrodou; Daniel Zachary; Marie Meister; Jules A Hoffmann; Charles A Janeway; Marie Lagueux
PVF2, a PDGF/VEGF-like growth factor, induces hemocyte proliferation in Drosophila larvae.
EMBO reports 2002;3(12):1195-200.
2002: Hilda Holcombe; Ira Mellman; Charles A Janeway; Kim Bottomly; Bonnie N Dittel
The immunosuppressive agent 15-deoxyspergualin functions by inhibiting cell cycle progression and cytokine production following naive T cell activation.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(9):4982-9.
2002: Xin He; Christophe Viret; Charles A Janeway
Self-recognition and the biased mature repertoire in TCR beta transgenic mice: the exception that supports the rule.
Trends in immunology 2002;23(10):467-9.
2002: Derek B Sant'Angelo; Eve Robinson; Charles A Janeway; Lisa K Denzin
Recognition of core and flanking amino acids of MHC class II-bound peptides by the T cell receptor.
European journal of immunology 2002;32(9):2510-20.
2002: Iqbal Grewal; Kate D Grewal; F Susan Wong; Hua Wang; Dominic E Picarella; Charles A Janeway; Richard A Flavell
Expression of transgene encoded TGF-beta in islets prevents autoimmune diabetes in NOD mice by a local mechanism.
Journal of autoimmunity 2002;19(1-2):9-22.
2002: Koichi Kobayashi; Lorraine D Hernandez; Jorge E Galán; Charles A Janeway; Ruslan Medzhitov; Richard A Flavell
IRAK-M is a negative regulator of Toll-like receptor signaling.
Cell 2002;110(2):191-202.
2002: Derek B Sant'Angelo; Charles A Janeway
Negative selection of thymocytes expressing the D10 TCR.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(10):6931-6.
2002: F Susan Wong; Antonis K Moustakas; Li Wen; George K Papadopoulos; Charles A Janeway
Analysis of structure and function relationships of an autoantigenic peptide of insulin bound to H-2K(d) that stimulates CD8 T cells in insulin-dependent diabetes mellitus.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(8):5551-6.
2002: Ruslan Medzhitov; Charles A Janeway
Decoding the patterns of self and nonself by the innate immune system.
Science (New York, N.Y.) 2002;296(5566):298-300.
2002: Koichi Kobayashi; Naohiro Inohara; Lorraine D Hernandez; Jorge E Galán; Gabriel Núñez; Charles A Janeway; Ruslan Medzhitov; Richard A Flavell
RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems.
Nature 2002;416(6877):194-9.
2002: Xin He; Charles A Janeway; Matthew Levine; Eve Robinson; Paula Preston-Hurlburt; Christophe Viret; Kim Bottomly
Dual receptor T cells extend the immune repertoire for foreign antigens.
Nature immunology 2002;3(2):127-34.
2002: Charles A Janeway; Ruslan Medzhitov
Innate immune recognition.
Annual review of immunology 2002;20():197-216.
2002: Charles A Janeway
A trip through my life with an immunological theme.
Annual review of immunology 2002;20():1-28.
2001: Charles A Janeway
How the immune system protects the host from infection.
Microbes and infection / Institut Pasteur 2001;3(13):1167-71.
2001: G Das; S Sheridan; Charles A Janeway
The source of early IFN-gamma that plays a role in Th1 priming.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(4):2004-10.
2001: Christophe Viret; Xin He; Charles A Janeway
Paradoxical intrathymic positive selection in mice with only a covalently presented agonist peptide.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(16):9243-8.
2001: Charles A Janeway
How the immune system works to protect the host from infection: a personal view.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(13):7461-8.
2001: Derek B Sant'Angelo; Peter Cresswell; Charles A Janeway; Lisa K Denzin
Maintenance of TCR clonality in T cells expressing genes for two TCR heterodimers.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(12):6824-9.
2001: Christophe Viret; Derek B Sant'Angelo; X He; H Ramaswamy; Charles A Janeway
A role for accessibility to self-peptide-self-MHC complexes in intrathymic negative selection.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(7):4429-37.
2000: Bonnie N Dittel; Charles A Janeway
Differential sensitivity to mutations in a single peptide by two TCRs having identical beta-chains and closely related alpha-chains.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(11):6334-40.
2000: Christophe Viret; X He; Charles A Janeway
On the self-referential nature of naive MHC class II-restricted T cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(11):6183-92.
2000: Gobardhan Das; DS Gould; M M Augustine; G Fragoso; E Sciutto; I Stroynowski; Luc Van Kaer; Daniel J Schust; Hidde L Ploegh; Charles A Janeway; E Scitto
Qa-2-dependent selection of CD8alpha/alpha T cell receptor alpha/beta(+) cells in murine intestinal intraepithelial lymphocytes.
The Journal of experimental medicine 2000;192(10):1521-8.
2000: Charles A Janeway; Ruslan Medzhitov
Viral interference with IL-1 and toll signaling.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(20):10682-3.
2000: Christophe Viret; Olivier Lantz; X He; Albert Bendelac; Charles A Janeway
A NK1.1+ thymocyte-derived TCR beta-chain transgene promotes positive selection of thymic NK1.1+ alpha beta T cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(6):3004-14.
2000: Julie M. Blander; Derek B Sant'Angelo; Kim Bottomly; Charles A Janeway
Alteration at a single amino acid residue in the T cell receptor alpha chain complementarity determining region 2 changes the differentiation of naive CD4 T cells in response to antigen from T helper cell type 1 (Th1) to Th2.
The Journal of experimental medicine 2000;191(12):2065-74.
2000: Ruslan Medzhitov; Charles A Janeway
How does the immune system distinguish self from nonself?
Seminars in immunology 2000;12(3):185-8; discussion 257-344.
2000: Bonnie N Dittel; T H Urbania; Charles A Janeway
Relapsing and remitting experimental autoimmune encephalomyelitis in B cell deficient mice.
Journal of autoimmunity 2000;14(4):311-8.
2000: Michael D Carrithers; Irene Visintin; S J Kang; Charles A Janeway
Differential adhesion molecule requirements for immune surveillance and inflammatory recruitment.
Brain : a journal of neurology 2000;123 ( Pt 6)():1092-101.
2000: Christophe Viret; Charles A Janeway
Functional and phenotypic evidence for presentation of E alpha 52-68 structurally related self-peptide(s) in I-E alpha-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(9):4627-34.
2000: Christophe Viret; A K Barlow; Charles A Janeway
Polymorphism of the mouse T-cell receptor AV20S1 gene.
Immunogenetics 2000;51(4-5):392-4.
2000: M H Levine; Ann M Haberman; Derek B Sant'Angelo; Lynn G Hannum; M P Cancro; Charles A Janeway; Mark J Shlomchik
A B-cell receptor-specific selection step governs immature to mature B cell differentiation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(6):2743-8.
2000: R Medzhitov; Charles A Janeway
Innate immune recognition: mechanisms and pathways.
Immunological reviews 2000;173():89-97.
1999: Charles A Janeway; Ruslan Medzhitov
Lipoproteins take their toll on the host.
Current biology : CB 1999;9(23):R879-82.
1999: F Susan Wong; Charles A Janeway
The role of CD4 vs. CD8 T cells in IDDM.
Journal of autoimmunity 1999;13(3):290-5.
1999: Julie M. Blander; Irene Visintin; Charles A Janeway; Ruslan Medzhitov
Alpha(1,3)-fucosyltransferase VII and alpha(2,3)-sialyltransferase IV are up-regulated in activated CD4 T cells and maintained after their differentiation into Th1 and migration into inflammatory sites.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(7):3746-52.
1999: Gobardhan Das; Charles A Janeway
Development of CD8alpha/alpha and CD8alpha/beta T cells in major histocompatibility complex class I-deficient mice.
The Journal of experimental medicine 1999;190(6):881-4.
1999: Bonnie N Dittel; Irena Stefanova; Ronald N Germain; Charles A Janeway
Cross-antagonism of a T cell clone expressing two distinct T cell receptors.
Immunity 1999;11(3):289-98.
1999: F Susan Wong; J Karttunen; C Dumont; Li Wen; Irene Visintin; IM Pilip; N Shastri; Eric G Pamer; Charles A Janeway
Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library.
Nature medicine 1999;5(9):1026-31.
1999: Elizabeth Kopp; Ruslan Medzhitov; J Carothers; Changchun Xiao; I Douglas; Charles A Janeway; Sankar Ghosh
ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway.
Genes & development 1999;13(16):2059-71.
1999: Bonnie N Dittel; Irene Visintin; R M Merchant; Charles A Janeway
Presentation of the self antigen myelin basic protein by dendritic cells leads to experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(1):32-9.
1999: F S Wong; Bonnie N Dittel; Charles A Janeway
Transgenes and knockout mutations in animal models of type 1 diabetes and multiple sclerosis.
Immunological reviews 1999;169():93-104.
1999: Bonnie N Dittel; R M Merchant; Charles A Janeway
Evidence for Fas-dependent and Fas-independent mechanisms in the pathogenesis of experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(11):6392-400.
1999: Charles A Janeway
T-cell development: a role for self-peptides in positive selection.
Current biology : CB 1999;9(9):R342-5.
1999: Christophe Viret; F Susan Wong; Charles A Janeway
Designing and maintaining the mature TCR repertoire: the continuum of self-peptide:self-MHC complex recognition.
Immunity 1999;10(5):559-68.
1999: Charles A Janeway
The discovery of T cell help for B cell antibody formation: a perspective from the 30th anniversary of this discovery.
Immunology and cell biology 1999;77(2):177-9.
1999: T Welte; David Leitenberg; Bonnie N Dittel; Basel K al-Ramadi; B Xie; Y Eugene Chin; Charles A Janeway; Alfred L M Bothwell; Kim Bottomly; Xin-Yuan Fu
STAT5 interaction with the T cell receptor complex and stimulation of T cell proliferation.
Science (New York, N.Y.) 1999;283(5399):222-5.
1999: Christophe Viret; Charles A Janeway
MHC and T cell development.
Reviews in immunogenetics 1999;1(1):91-104.
1999: Ruslan Medzhitov; Charles A Janeway
Innate immune induction of the adaptive immune response.
Cold Spring Harbor symposia on quantitative biology 1999;64():429-35.
1999: T Welte; David Leitenberg; Bonnie N Dittel; Basel K al-Ramadi; W R Hansen; B Xie; Charles A Janeway; Alfred L M Bothwell; Kim Bottomly; Xin-Yuan Fu
The PTK-STAT signaling pathway has essential roles in T-cell activation in response to antigen stimulation.
Cold Spring Harbor symposia on quantitative biology 1999;64():291-302.
1999: Charles A Janeway
The role of self-recognition in receptor repertoire development. Members of the Janeway Laboratory.
Immunologic research 1999;19(2-3):107-18.
1999: Charles A Janeway; Richard A Flavell
Immunology at Yale.
Immunologic research 1999;19(2-3):105-6.
1999: Christophe Viret; A K Barlow; Charles A Janeway
On the intrathymic intercellular transfer of self-determinants.
Immunology today 1999;20(1):8-10.
1998: F Susan Wong; Irene Visintin; Marya Shanabrough; Csaba Leranth; Charles A Janeway
A novel method for concurrent visualization of immunostain under light and electron microscopy in pancreatic islets.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1998;46(12):1341-6.
1998: Ruslan Medzhitov; Charles A Janeway
Innate immune recognition and control of adaptive immune responses.
Seminars in immunology 1998;10(5):351-3.
1998: Alexander V Chervonsky; Ruslan Medzhitov; Lisa K Denzin; A K Barlow; A Y Rudensky; Charles A Janeway
Subtle conformational changes induced in major histocompatibility complex class II molecules by binding peptides.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(17):10094-9.
1998: Ruslan Medzhitov; Paula Preston-Hurlburt; Elizabeth Kopp; A Stadlen; C Chen; Sankar Ghosh; Charles A Janeway
MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways.
Molecular cell 1998;2(2):253-8.
1998: Derek B Sant'Angelo; Bruno LUCAS; PG Waterbury; B Cohen; Thea Brabb; Joan Goverman; Ronald N Germain; Charles A Janeway
A molecular map of T cell development.
Immunity 1998;9(2):179-86.
1998: Charles A Janeway
Presidential Address to The American Association of Immunologists. The road less traveled by: the role of innate immunity in the adaptive immune response.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(2):539-44.
1998: F Susan Wong; Irene Visintin; Li Wen; J Granata; Richard A Flavell; Charles A Janeway
The role of lymphocyte subsets in accelerated diabetes in nonobese diabetic-rat insulin promoter-B7-1 (NOD-RIP-B7-1) mice.
The Journal of experimental medicine 1998;187(12):1985-93.
1998: A K Barlow; X He; Charles A Janeway
Exogenously provided peptides of a self-antigen can be processed into forms that are recognized by self-T cells.
The Journal of experimental medicine 1998;187(9):1403-15.
1998: Charles A Janeway
A tale of two T cells.
Immunity 1998;8(4):391-4.
1998: Ruslan Medzhitov; Charles A Janeway
Self-defense: the fruit fly style.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(2):429-30.
1997: Soon-Cheol Hong; Derek B Sant'Angelo; Bonnie N Dittel; Ruslan Medzhitov; S T Yoon; PG Waterbury; Charles A Janeway
The orientation of a T cell receptor to its MHC class II:peptide ligands.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(9):4395-402.
1997: Ruslan Medzhitov; Charles A Janeway
Innate immunity: the virtues of a nonclonal system of recognition.
Cell 1997;91(3):295-8.
1997: Jean-Luc Dimarcq; Jean-Luc Imler; René Lanot; R A Ezekowitz; Jules A Hoffmann; Charles A Janeway; Marie Lagueux
Treatment of l(2)mbn Drosophila tumorous blood cells with the steroid hormone ecdysone amplifies the inducibility of antimicrobial peptide gene expression.
Insect biochemistry and molecular biology 1997;27(10):877-86.
1997: Derek B Sant'Angelo; PG Waterbury; B E Cohen; W D Martin; Luc Van Kaer; Adrian C Hayday; Charles A Janeway
The imprint of intrathymic self-peptides on the mature T cell receptor repertoire.
Immunity 1997;7(4):517-24.
1997: Ruslan Medzhitov; Paula Preston-Hurlburt; Charles A Janeway
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity.
Nature 1997;388(6640):394-7.
1997: F Susan Wong; Charles A Janeway
The role of CD4 and CD8 T cells in type I diabetes in the NOD mouse.
Research in immunology 1997;148(5):327-32.
1997: Bonnie N Dittel; Derek B Sant'Angelo; Charles A Janeway
Peptide antagonists inhibit proliferation and the production of IL-4 and/or IFN-gamma in T helper 1, T helper 2, and T helper 0 clones bearing the same TCR.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(9):4065-73.
1997: Charles A Janeway; Alexander V Chervonsky; Derek B Sant'Angelo
T-cell receptors: is the repertoire inherently MHC-specific?
Current biology : CB 1997;7(5):R299-300.
1997: Alexander V Chervonsky; Yuqi Wang; F Susan Wong; Irene Visintin; Richard A Flavell; Charles A Janeway; LA Matis
The role of Fas in autoimmune diabetes.
Cell 1997;89(1):17-24.
1997: A M Romanic; Donnasue Graesser; J L Baron; Irene Visintin; Charles A Janeway; Joseph A Madri
T cell adhesion to endothelial cells and extracellular matrix is modulated upon transendothelial cell migration.
Laboratory investigation; a journal of technical methods and pathology 1997;76(1):11-23.
1996: S D Wolf; Bonnie N Dittel; F Hardardottir; Charles A Janeway
Experimental autoimmune encephalomyelitis induction in genetically B cell-deficient mice.
The Journal of experimental medicine 1996;184(6):2271-8.
1996: Iqbal Grewal; K D Grewal; F Susan Wong; D E Picarella; Charles A Janeway; Richard A Flavell
Local expression of transgene encoded TNF alpha in islets prevents autoimmune diabetes in nonobese diabetic (NOD) mice by preventing the development of auto-reactive islet-specific T cells.
The Journal of experimental medicine 1996;184(5):1963-74.
1996: Iqbal Grewal; H G Foellmer; K D Grewal; J Xu; F Hardardottir; J L Baron; Charles A Janeway; Richard A Flavell
Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis.
Science (New York, N.Y.) 1996;273(5283):1864-7.
1996: Ruslan Medzhitov; Charles A Janeway
On the semantics of immune recognition.
Research in immunology 1996;147(4):208-14.
1996: Charles A Janeway; C C Goodnow; Ruslan Medzhitov
Danger - pathogen on the premises! Immunological tolerance.
Current biology : CB 1996;6(5):519-22.
1996: Charles A Janeway; Kim Bottomly
Responses of T cells to ligands for the T-cell receptor.
Seminars in immunology 1996;8(2):108-115.
1996: Soon-Cheol Hong; G Waterbury; Charles A Janeway
Different superantigens interact with distinct sites in the Vbeta domain of a single T cell receptor.
The Journal of experimental medicine 1996;183(4):1437-46.
1996: Derek B Sant'Angelo; G Waterbury; Paula Preston-Hurlburt; S T Yoon; Ruslan Medzhitov; Soon-Cheol Hong; Charles A Janeway
The specificity and orientation of a TCR to its peptide-MHC class II ligands.
Immunity 1996;4(4):367-76.
1996: F Susan Wong; Irene Visintin; Li Wen; Richard A Flavell; Charles A Janeway
CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.
The Journal of experimental medicine 1996;183(1):67-76.
1995: Alexander V Chervonsky; Tatyana V Golovkina; Susan R Ross; Charles A Janeway
Differences in the avidity of TCR interactions with a superantigenic ligand affect negative selection but do not allow positive selection.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(11):5115-23.
1995: Cheong-Hee Chang; Soon-Cheol Hong; C C Hughes; Charles A Janeway; Richard A Flavell
CIITA activates the expression of MHC class II genes in mouse T cells.
International immunology 1995;7(9):1515-8.
1995: Alexander V Chervonsky; J Xu; A K Barlow; M Khery; Richard A Flavell; Charles A Janeway
Direct physical interaction involving CD40 ligand on T cells and CD40 on B cells is required to propagate MMTV.
Immunity 1995;3(1):139-46.
1995: Charles A Janeway
Ligands for the T-cell receptor: hard times for avidity models.
Immunology today 1995;16(5):223-5.
1995: S Wong; S Guerder; Irene Visintin; E P Reich; K E Swenson; Richard A Flavell; Charles A Janeway
Expression of the co-stimulator molecule B7-1 in pancreatic beta-cells accelerates diabetes in the NOD mouse.
Diabetes 1995;44(3):326-9.
1995: F Hardardottir; J L Baron; Charles A Janeway
T cells with two functional antigen-specific receptors.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(2):354-8.
1994: S T Yoon; Umberto Dianzani; Kim Bottomly; Charles A Janeway
Both high and low avidity antibodies to the T cell receptor can have agonist or antagonist activity.
Immunity 1994;1(7):563-9.
1994: Junji Yagi; M Nakata; Tsuyoshi Uchiyama; M Nishikawa; Y Mizushima; K Nishioka; K Ito; H Yagita; K Okumura; Charles A Janeway
Superantigen-like properties of an antibody bispecific for MHC class II molecules and the V beta domain of the T cell antigen receptor.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(8):3833-41.
1994: Charles A Janeway
Thymic selection: two pathways to life and two to death.
Immunity 1994;1(1):3-6.
1994: J L Baron; E P Reich; Irene Visintin; Charles A Janeway
The pathogenesis of adoptive murine autoimmune diabetes requires an interaction between alpha 4-integrins and vascular cell adhesion molecule-1.
The Journal of clinical investigation 1994;93(4):1700-8.
1994: E P Reich; Hermann von Grafenstein; A Barlow; K E Swenson; K Williams; Charles A Janeway
Self peptides isolated from MHC glycoproteins of non-obese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(5):2279-88.
1994: Tatyana V Golovkina; Alexander V Chervonsky; J A Prescott; Charles A Janeway; Susan R Ross
The mouse mammary tumor virus envelope gene product is required for superantigen presentation to T cells.
The Journal of experimental medicine 1994;179(2):439-46.
1994: Junji Yagi; Tsuyoshi Uchiyama; Charles A Janeway
Stimulator cell type influences the response of T cells to staphylococcal enterotoxins.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(3):1154-62.
1994: Charles A Janeway; Kim Bottomly
Signals and signs for lymphocyte responses.
Cell 1994;76(2):275-85.
1993: Y Sano; E Dudley; Simon R Carding; R H Lin; Adrian C Hayday; Charles A Janeway
Gamma delta T-cell lines isolated from intestinal epithelium respond to a B-cell lymphoma.
Immunology 1993;80(3):388-94.
1993: C H Wolff; Soon-Cheol Hong; Hermann von Grafenstein; Charles A Janeway
TCR-CD4 and TCR-TCR interactions as distinctive mechanisms for the induction of increased intracellular calcium in T-cell signalling.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(3):1337-45.
1993: Charles A Janeway; P Golstein
Lymphocyte activation and effector functions. Editorial overview. The role of cell surface molecules.
Current opinion in immunology 1993;5(3):313-23.
1993: Charles A Janeway
Co-receptor selection: chance or necessity?
Current biology : CB 1993;3(5):282-4.
1993: Mark J Mamula; Charles A Janeway
Do B cells drive the diversification of immune responses?
Immunology today 1993;14(4):151-2; discussion 153-4.
1993: Charles A Janeway
Are there cellular superantigens?
Immunological reviews 1993;131():189-200.
1993: Charles A Janeway; Mark J Mamula
Rules for peptide presentation by MHC class II molecules.
International reviews of immunology 1993;10(4):301-11.
1993: J L Baron; Joseph A Madri; Nancy H Ruddle; G Hashim; Charles A Janeway
Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma.
The Journal of experimental medicine 1993;177(1):57-68.
1992: Charles A Janeway
High fives or hand clasps?
Current biology : CB 1992;2(11):591-3.
1992: Yang Liu; B Jones; W Brady; Charles A Janeway; Peter Linsley; P S Linley
Co-stimulation of murine CD4 T cell growth: cooperation between B7 and heat-stable antigen.
European journal of immunology 1992;22(11):2855-9.
1992: H Wolff; T Novak; A Shaw; Umberto Dianzani; Charles A Janeway
High levels of IL-2 alter signal transduction in cloned IL-4-producing CD4 T cells.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(9):2996-3002.
1992: Paula Preston-Hurlburt; B K al-Ramadi; J Rothbard; Charles A Janeway
Truncation variants of peptides isolated from MHC class II molecules suggest sequence motifs.
Nature 1992;359(6394):429-31.
1992: Umberto Dianzani; A Shaw; M Fernandez-Cabezudo; Charles A Janeway
Extensive CD4 cross-linking inhibits T cell activation by anti-receptor antibody but not by antigen.
International immunology 1992;4(9):995-1001.
1992: S Rath; R H Lin; A Rudensky; Charles A Janeway
T and B cell receptors discriminate major histocompatibility complex class II conformations influenced by the invariant chain.
European journal of immunology 1992;22(8):2121-7.
1992: Mark J Mamula; R H Lin; Charles A Janeway; John Hardin
Breaking T cell tolerance with foreign and self co-immunogens. A study of autoimmune B and T cell epitopes of cytochrome c.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(3):789-95.
1992: Charles A Janeway
The case of the missing CD4s.
Current biology : CB 1992;2(7):359-61.
1992: Soon-Cheol Hong; A Chelouche; R H Lin; D Shaywitz; N S Braunstein; L Glimcher; Charles A Janeway
An MHC interaction site maps to the amino-terminal half of the T cell receptor alpha chain variable domain.
Cell 1992;69(6):999-1009.
1992: Yang Liu; Charles A Janeway
Cells that present both specific ligand and costimulatory activity are the most efficient inducers of clonal expansion of normal CD4 T cells.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(9):3845-9.
1992: Umberto Dianzani; A Shaw; Basel K al-Ramadi; R T Kubo; Charles A Janeway
Physical association of CD4 with the T cell receptor.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(3):678-88.
1992: Yang Liu; B Jones; A Aruffo; K M Sullivan; Peter Linsley; Charles A Janeway
Heat-stable antigen is a costimulatory molecule for CD4 T cell growth.
The Journal of experimental medicine 1992;175(2):437-45.
1992: Charles A Janeway; A Rudensky; S Rath; D Murphy
It is easier for a camel to pass the needle's eye.
Current biology : CB 1992;2(1):26-8.
1992: Charles A Janeway
The immune system evolved to discriminate infectious nonself from noninfectious self.
Immunology today 1992;13(1):11-6.
1992: Charles A Janeway
The T cell receptor as a multicomponent signalling machine: CD4/CD8 coreceptors and CD45 in T cell activation.
Annual review of immunology 1992;10():645-74.
1991: T Y Nakagawa; Hermann von Grafenstein; J E Sears; J Williams; Charles A Janeway; Richard A Flavell
The use of the polymerase chain reaction to map CD4+ T cell epitopes.
European journal of immunology 1991;21(11):2851-5.
1991: S Rath; Paula Preston-Hurlburt; D B Murphy; Charles A Janeway
On the complexity of self.
Nature 1991;353(6345):660-2.
1991: Paula Preston-Hurlburt; Soon-Cheol Hong; A Barlow; Charles A Janeway
Sequence analysis of peptides bound to MHC class II molecules.
Nature 1991;353(6345):622-7.
1991: Junji Yagi; S Rath; Charles A Janeway
Control of T cell responses to staphylococcal enterotoxins by stimulator cell MHC class II polymorphism.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(4):1398-405.
1991: Charles A Janeway
To thine own self be true...
Current biology : CB 1991;1(4):239-41.
1991: R H Lin; Mark J Mamula; John Hardin; Charles A Janeway
Induction of autoreactive B cells allows priming of autoreactive T cells.
The Journal of experimental medicine 1991;173(6):1433-9.
1991: M F McInerney; S Rath; Charles A Janeway
Exclusive expression of MHC class II proteins on CD45+ cells in pancreatic islets of NOD mice.
Diabetes 1991;40(5):648-51.
1991: Charles A Janeway
The co-receptor function of CD4.
Seminars in immunology 1991;3(3):153-60.
1991: Yang Liu; Charles A Janeway
Microbial induction of co-stimulatory activity for CD4 T-cell growth.
International immunology 1991;3(4):323-32.
1991: Charles A Janeway; S Rath; Junji Yagi
V beta selective elements: self and non-self.
Behring Institute Mitteilungen 1991;(88):177-82.
1991: Charles A Janeway
Selective elements for the V beta region of the T cell receptor: Mls and the bacterial toxic mitogens.
Advances in immunology 1991;50():1-53.
1991: Yang Liu; Charles A Janeway
Monoclonal antibodies against T cell receptor/CD3 complex induce cell death of Th1 clones in the absence of accessory cells.
Advances in experimental medicine and biology 1991;292():105-13.
1991: R Mann; E Dudley; Y Sano; R O'Brien; W Born; Charles A Janeway; Adrian C Hayday
Modulation of murine self antigens by mycobacterial components.
Current topics in microbiology and immunology 1991;173():151-7.
1990: Yang Liu; Charles A Janeway
Interferon gamma plays a critical role in induced cell death of effector T cell: a possible third mechanism of self-tolerance.
The Journal of experimental medicine 1990;172(6):1735-9.
1990: Charles A Janeway
Self superantigens?
Cell 1990;63(4):659-61.
1990: Umberto Dianzani; M Luqman; Jose M Rojo; Junji Yagi; J L Baron; A Woods; Charles A Janeway; Kim Bottomly
Molecular associations on the T cell surface correlate with immunological memory.
European journal of immunology 1990;20(10):2249-57.
1990: Charles A Janeway
Gamma delta T cells: research on the frontlines of defence.
Research in immunology 1990;141(7):688-95.
1990: Junji Yagi; J Baron; Stephen Buxser; Charles A Janeway
Bacterial proteins that mediate the association of a defined subset of T cell receptor:CD4 complexes with class II MHC.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(3):892-901.
1990: Junji Yagi; Charles A Janeway
Ligand thresholds at different stages of T cell development.
International immunology 1990;2(1):83-9.
1990: Wlodzimierz Ptak; Patrick M Flood; Charles A Janeway
Antibody-activated immunoregulatory T cells are defective in B cell deprived mice.
The Journal of molecular and cellular immunology : JMCI 1990;4(5):281-9; discussion 289-90.
1989: E P Reich; D Scaringe; Junji Yagi; Robert S Sherwin; Charles A Janeway
Prevention of diabetes in NOD mice by injection of autoreactive T-lymphocytes.
Diabetes 1989;38(12):1647-51.
1989: Jose M Rojo; J D Kerner; Charles A Janeway
Selective induction of growth factor production and growth factor receptor expression by different signals to a single T cell.
European journal of immunology 1989;19(11):2061-7.
1989: E P Reich; Robert S Sherwin; O Kanagawa; Charles A Janeway
An explanation for the protective effect of the MHC class II I-E molecule in murine diabetes.
Nature 1989;341(6240):326-8.
1989: Charles A Janeway
The priming of helper T cells.
Seminars in immunology 1989;1(1):13-20.
1989: S H Gromkowski; Junji Yagi; Charles A Janeway
Elevated temperature regulates tumor necrosis factor-mediated immune killing.
European journal of immunology 1989;19(9):1709-14.
1989: S Kyes; E Carew; Simon R Carding; Charles A Janeway; Adrian C Hayday
Diversity in T-cell receptor gamma gene usage in intestinal epithelium.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(14):5527-31.
1989: T N Marion; Alfred L M Bothwell; D E Briles; Charles A Janeway
IgG anti-DNA autoantibodies within an individual autoimmune mouse are the products of clonal selection.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(12):4269-74.
1989: P Portoles; Jose M Rojo; A Golby; M Bonneville; S Gromkowski; L Greenbaum; Charles A Janeway; D B Murphy; Kim Bottomly
Monoclonal antibodies to murine CD3 epsilon define distinct epitopes, one of which may interact with CD4 during T cell activation.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(12):4169-75.
1989: Charles A Janeway; Jose M Rojo; K Saizawa; Umberto Dianzani; P Portoles; J Tite; S Haque; B Jones
The co-receptor function of murine CD4.
Immunological reviews 1989;109():77-92.
1989: Jose M Rojo; K Saizawa; Charles A Janeway
Physical association of CD4 and the T-cell receptor can be induced by anti-T-cell receptor antibodies.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(9):3311-5.
1989: D B Murphy; D Lo; S Rath; R L Brinster; Richard A Flavell; A Slanetz; Charles A Janeway
A novel MHC class II epitope expressed in thymic medulla but not cortex.
Nature 1989;338(6218):765-8.
1989: Charles A Janeway; Junji Yagi; P J Conrad; M E Katz; B Jones; S Vroegop; Stephen Buxser
T-cell responses to Mls and to bacterial proteins that mimic its behavior.
Immunological reviews 1989;107():61-88.
1989: P Portoles; Charles A Janeway
Inhibition of the responses of a cloned CD4+ T cell line to different class II major histocompatibility complex ligands by anti-CD4 and by anti-receptor Fab fragments are directly related.
European journal of immunology 1989;19(1):83-7.
1989: Charles A Janeway; Umberto Dianzani; P Portoles; S Rath; E P Reich; Jose M Rojo; Junji Yagi; D B Murphy
Cross-linking and conformational change in T-cell receptors: role in activation and in repertoire selection.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 2():657-66.
1989: Charles A Janeway
Approaching the asymptote? Evolution and revolution in immunology.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 1():1-13.
1989: P Portoles; Jose M Rojo; Charles A Janeway
Asymmetry in the recognition of antigen: self class II MHC and non-self class II MHC molecules by the same T-cell receptor.
The Journal of molecular and cellular immunology : JMCI 1989;4(3):129-37.
1988: B Jones; Simon R Carding; S Kyes; S Mjolsness; Charles A Janeway; Adrian C Hayday
Molecular analysis of T cell receptor gamma gene expression in allo-activated splenic T cells of adult mice.
European journal of immunology 1988;18(12):1907-15.
1988: John W Chamberlain; J A Nolan; P J Conrad; H A Vasavada; H H Vasavada; H L Ploegh; S Ganguly; Charles A Janeway; S M Weissman
Tissue-specific and cell surface expression of human major histocompatibility complex class I heavy (HLA-B7) and light (beta 2-microglobulin) chain genes in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(20):7690-4.
1988: S H Gromkowski; K M Hepler; Charles A Janeway
Low doses of interleukin 2 induce bystander cell lysis by antigen-specific CD4+ inflammatory T cell clones in short-term assay.
European journal of immunology 1988;18(9):1385-9.
1988: S D Conzen; Charles A Janeway
Defective antigen presentation in chronically protein-deprived mice.
Immunology 1988;63(4):683-9.
1988: WJ Poo; L Conrad; Charles A Janeway
Receptor-directed focusing of lymphokine release by helper T cells.
Nature 1988;332(6162):378-80.
1988: John W Chamberlain; J A Nolan; S H Gromkowski; Kevin A Kelley; J M Eisenstadt; Karl Herrup; Charles A Janeway; S M Weissman
Cell surface expression and alloantigenic function of a human class I MHC heavy chain gene (HLA-B7) in transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(4):1285-92.
1988: Jose M Rojo; Charles A Janeway
The biologic activity of anti-T cell receptor V region monoclonal antibodies is determined by the epitope recognized.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(4):1081-8.
1988: Charles A Janeway; J Chalupny; P J Conrad; Stephen Buxser
An external stimulus that mimics Mls locus responses.
Journal of immunogenetics 1988;15(1-3):161-8.
1988: Charles A Janeway
The Mls locus: past, present and future.
Journal of immunogenetics 1988;15(1-3):1-4.
1988: Charles A Janeway; Junji Yagi; Jose M Rojo; P Portoles; Simon R Carding; M Luqman; Kim Bottomly
Immune recognition and effector function in subsets of CD4 T cells.
Princess Takamatsu symposia 1988;19():193-208.
1988: Charles A Janeway; Simon R Carding; B Jones; J Murray; P Portoles; R Rasmussen; Jose M Rojo; K Saizawa; J West; Kim Bottomly
CD4+ T cells: specificity and function.
Immunological reviews 1988;101():39-80.
1987: S Haque; K Saizawa; Jose M Rojo; Charles A Janeway
The influence of valence on the functional activities of monoclonal anti-L3T4 antibodies. Discrimination of signaling from other effects.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(10):3207-12.
1987: John Tite; H G Foellmer; Joseph A Madri; Charles A Janeway
Inverse Ir gene control of the antibody and T cell proliferative responses to human basement membrane collagen.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(9):2892-8.
1987: J B Horowitz; J Kaye; M E Katz; Charles A Janeway
Ability of fixed B-lymphoma cells to present foreign protein antigen fragments and allogenic MHC molecules to a cloned helper-T-cell line.
Cellular immunology 1987;109(2):429-36.
1987: K Saizawa; Jose M Rojo; Charles A Janeway
Evidence for a physical association of CD4 and the CD3:alpha:beta T-cell receptor.
Nature 1987;328(6127):260-3.
1987: Charles A Janeway; B Broughton; L A Smith; T N Marion; Kim Bottomly
Direct receptor:receptor interactions between T and B lymphocytes: idiotypic restriction in the antibody response to a cloned helper T cell receptor.
The Journal of molecular and cellular immunology : JMCI 1987;3(2):83-94.
1987: Charles A Janeway; S Haque; L A Smith; K Saizawa
The role of the murine L3T4 molecule in T cell activation: differential effects of anti-L3T4 on activation by monoclonal anti-receptor antibodies.
The Journal of molecular and cellular immunology : JMCI 1987;3(2):121-31.
1987: K Saizawa; S Haque; B Jones; Jose M Rojo; John Tite; J Kaye; Charles A Janeway
The L3T4 molecule is part of the helper T-cell antigen/Ia recognition complex.
Annales de l'Institut Pasteur. Immunology 1987;138(1):138-43.
1986: B Jones; S Mjolsness; Charles A Janeway; Adrian C Hayday
Transcripts of functionally rearranged gamma genes in primary T cells of adult immunocompetent mice.
Nature 1986;323(6089):635-8.
1986: J B Horowitz; J Kaye; P J Conrad; M E Katz; Charles A Janeway
Autocrine growth inhibition of a cloned line of helper T cells.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(6):1886-90.
1986: John Tite; A Sloan; Charles A Janeway
The role of L3T4 in T cell activation: L3T4 may be both an Ia-binding protein and a receptor that transduces a negative signal.
The Journal of molecular and cellular immunology : JMCI 1986;2(4):179-90.
1986: John Tite; J Kaye; K M Saizawa; J Ming; M E Katz; L A Smith; Charles A Janeway
Direct interactions between B and T lymphocytes bearing complementary receptors.
The Journal of experimental medicine 1986;163(1):189-202.
1986: Charles A Janeway
Varieties of idiotype-specific helper T cells--a commentary.
The Journal of molecular and cellular immunology : JMCI 1986;2(5):265-7.
1986: Charles A Janeway; John Tite; J Horowitz; P J Conrad; J Kaye; B Jones; K Bottomly
Cell interactions in the immune system: the role of self recognition in the targeting of nonspecific effector molecules by helper T cells.
Symposium on Fundamental Cancer Research 1986;38():45-61.
1985: Charles A Janeway; John Tite; Kim Bottomly; Patrick M Flood
The role of immunoglobulin and B cells in T cell ontogeny and repertoire formation--a commentary.
The Journal of molecular and cellular immunology : JMCI 1985;2(2):118-20.
1984: John Tite; Charles A Janeway
Antigen-dependent selection of B lymphoma cells varying in Ia density by cloned antigen-specific L3T4a+ T cells: a possible in vitro model for B cell adaptive differentiation.
The Journal of molecular and cellular immunology : JMCI 1984;1(4):253-65.
1984: Patrick M Flood; Charles A Janeway; R K Gershon
B cell-deprived mice lack functional expression of certain T suppressor cell subsets.
The Journal of molecular and cellular immunology : JMCI 1984;1(3):167-76.
1983: Kim Bottomly; Jeffrey A Kaye; B Jones; F Jones; Charles A Janeway
A cloned, antigen-specific, Ia-restricted Lyt-1+,2- T cell with suppressive activity.
The Journal of molecular and cellular immunology : JMCI 1983;1(1):42-9.
1980: Charles A Janeway; J M Jason; E A Lerner; B Jones
T lymphocytes responding to Mls-locus antigens are Lyt-1+, 2- and I-A restricted.
Immunogenetics 1980;10(5):481-97.