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Juhani Jänne

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Marc Cerrada-Gimenez; Marko Pietilä; Suvikki Loimas; Eija Pirinen; Mervi T Hyvönen; Tuomo A Keinänen; Juhani Jänne; Leena Alhonen
Continuous oxidative stress due to activation of polyamine catabolism accelerates aging and protects against hepatotoxic insults.
Susanna Vuohelainen; Eija Pirinen; Marc Cerrada-Gimenez; Tuomo A Keinänen; Anne Uimari; Marko Pietilä; Alex R Khomutov; Juhani Jänne; Leena Alhonen
Spermidine is indispensable in differentiation of 3T3-L1 fibroblasts to adipocytes.
Marc Cerrada-Gimenez; Jukka Häyrinen; Sisko Juutinen; Tuula Reponen; Juhani Jänne; Leena Alhonen
Proteomic analysis of livers from a transgenic mouse line with activated polyamine catabolism.

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All Publications

2011: Marc Cerrada-Gimenez; Marko Pietilä; Suvikki Loimas; Eija Pirinen; Mervi T Hyvönen; Tuomo A Keinänen; Juhani Jänne; Leena Alhonen
Continuous oxidative stress due to activation of polyamine catabolism accelerates aging and protects against hepatotoxic insults.
Transgenic research 2011;20(2):387-96.
2010: Susanna Vuohelainen; Eija Pirinen; Marc Cerrada-Gimenez; Tuomo A Keinänen; Anne Uimari; Marko Pietilä; Alex R Khomutov; Juhani Jänne; Leena Alhonen
Spermidine is indispensable in differentiation of 3T3-L1 fibroblasts to adipocytes.
Journal of cellular and molecular medicine 2010;14(6B):1683-92.
2010: Marc Cerrada-Gimenez; Jukka Häyrinen; Sisko Juutinen; Tuula Reponen; Juhani Jänne; Leena Alhonen
Proteomic analysis of livers from a transgenic mouse line with activated polyamine catabolism.
Amino acids 2010;38(2):613-22.
2010: Eija Pirinen; Helena Gylling; Paula Itkonen; Nagendra Yaluri; Sami Heikkinen; Marko Pietilä; Teemu Kuulasmaa; Maija Tusa; Marc Cerrada-Gimenez; Jussi Pihlajamäki; Leena Alhonen; Juhani Jänne; Tatu A Miettinen; Markku Laakso
Activated polyamine catabolism leads to low cholesterol levels by enhancing bile acid synthesis.
Amino acids 2010;38(2):549-60.
2010: Tekele Markos Fashe; Tuomo A Keinänen; Nikolay Grigorenko; Alex R Khomutov; Juhani Jänne; Leena Alhonen; Marko Pietilä
Cutaneous application of alpha-methylspermidine activates the growth of resting hair follicles in mice.
Amino acids 2010;38(2):583-90.
2009: Mervi T Hyvönen; Michael T Howard; Christine B Anderson; Nikolay Grigorenko; Alex R Khomutov; Jouko Vepsäläinen; Leena Alhonen; Juhani Jänne; Tuomo A Keinänen
Divergent regulation of the key enzymes of polyamine metabolism by chiral alpha-methylated polyamine analogues.
The Biochemical journal 2009;422(2):321-8.
2009: Anne Uimari; Tuomo A Keinänen; Anne Karppinen; Patrick M Woster; Pekka Uimari; Juhani Jänne; Leena Alhonen
Spermine analogue-regulated expression of spermidine/spermine N1-acetyltransferase and its effects on depletion of intracellular polyamine pools in mouse fetal fibroblasts.
The Biochemical journal 2009;422(1):101-9.
2008: Merja R Häkkinen; Tuomo A Keinänen; Jouko Vepsäläinen; Alex R Khomutov; Leena Alhonen; Juhani Jänne; Seppo Auriola
Quantitative determination of underivatized polyamines by using isotope dilution RP-LC-ESI-MS/MS.
Journal of pharmaceutical and biomedical analysis 2008;48(2):414-21.
2008: S Oikari; T Ahtialansaari; A Huotari; Karlheinz Kiehne; Ulrich R Fölsch; S Wolffram; Juhani Jänne; Leena Alhonen; Karl-Heinz Herzig
Effect of medium- and long-chain fatty acid diets on PPAR and SREBP-1 expression and glucose homeostasis in ACBP-overexpressing transgenic rats.
Acta physiologica (Oxford, England) 2008;194(1):57-65.
2008: Sanna Oikari; Tiia Ahtialansaari; Miika V Heinonen; Timo Mauriala; Seppo Auriola; Karlheinz Kiehne; Ulrich R Fölsch; Juhani Jänne; Leena Alhonen; Karl-Heinz Herzig
Downregulation of PPARs and SREBP by acyl-CoA-binding protein overexpression in transgenic rats.
Pflügers Archiv : European journal of physiology 2008;456(2):369-77.
2007: Merja R Häkkinen; Tuomo A Keinänen; Jouko Vepsäläinen; Alex R Khomutov; Leena Alhonen; Juhani Jänne; Seppo Auriola
Analysis of underivatized polyamines by reversed phase liquid chromatography with electrospray tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis 2007;45(4):625-34.
2007: Mervi T Hyvönen; Tuomo A Keinänen; Marc Cerrada-Gimenez; Riitta Sinervirta; Nikolay Grigorenko; Alex R Khomutov; Jouko Vepsäläinen; Leena Alhonen; Juhani Jänne
Role of hypusinated eukaryotic translation initiation factor 5A in polyamine depletion-induced cytostasis.
The Journal of biological chemistry 2007;282(48):34700-6.
2007: Tuomo A Keinänen; Aki Järvinen; Anne Uimari; Jouko Vepsäläinen; Alex R Khomutov; Nikolay Grigorenko; Mervi T Hyvönen; Marc Cerrada-Gimenez; Leena Alhonen; Juhani Jänne
Alpha-methylated polyamines as potential drugs and experimental tools in enzymology.
Mini reviews in medicinal chemistry 2007;7(8):813-20.
2007: M Merentie; Anne Uimari; Marko Pietilä; Riitta Sinervirta; Tuomo A Keinänen; Jouko Vepsäläinen; Alex R Khomutov; Nikolay Grigorenko; Karl-Heinz Herzig; Juhani Jänne; Leena Alhonen
Oxidative stress and inflammation in the pathogenesis of activated polyamine catabolism-induced acute pancreatitis.
Amino acids 2007;33(2):323-30.
2007: Eija Pirinen; Tiina Kuulasmaa; Marko Pietilä; Sami Heikkinen; Maija Tusa; Paula Itkonen; Susanna Boman; Joanna Skommer; Antti Virkamäki; Esa Hohtola; Mikko I Kettunen; Szabolcs Fatrai; Emilia Kansanen; Suvi Koota; Kirsi Niiranen; Jyrki Parkkinen; Anna-Liisa Levonen; Seppo Ylä-Herttuala; J Kalervo Hiltunen; Leena Alhonen; Ulf Smith; Juhani Jänne; Markku Laakso
Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism.
Molecular and cellular biology 2007;27(13):4953-67.
2007: Mervi T Hyvönen; M Merentie; Anne Uimari; Tuomo A Keinänen; Juhani Jänne; Leena Alhonen
Mechanisms of polyamine catabolism-induced acute pancreatitis.
Biochemical Society transactions 2007;35(Pt 2):326-30.
2007: Hanna Siiskonen; Sanna Oikari; Veli-Pekka Korhonen; Asla Pitkänen; Vootele Voikar; Mikko I Kettunen; Juhana M Hakumäki; Tiina Wahlfors; Raimo Pussinen; Markku Penttonen; Karlheinz Kiehne; Selma K Kaasinen; Leena Alhonen; Juhani Jänne; Karl-Heinz Herzig
Diazepam binding inhibitor overexpression in mice causes hydrocephalus, decreases plasticity in excitatory synapses and impairs hippocampus-dependent learning.
Molecular and cellular neurosciences 2007;34(2):199-208.
2006: Kirsi Niiranen; Tuomo A Keinänen; Eija Pirinen; Sami Heikkinen; Maija Tusa; Szabolcs Fatrai; Suvikki Suppola; Marko Pietilä; Anne Uimari; Markku Laakso; Leena Alhonen; Juhani Jänne
Mice with targeted disruption of spermidine/spermine N1-acetyltransferase gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging.
Journal of cellular and molecular medicine 2006;10(4):933-45.
2006: Mervi T Hyvönen; Anne Uimari; Tuomo A Keinänen; Sami Heikkinen; Riikka Pellinen; Tiina Wahlfors; Arja Korhonen; Ale Närvänen; Jarmo Wahlfors; Leena Alhonen; Juhani Jänne
Polyamine-regulated unproductive splicing and translation of spermidine/spermine N1-acetyltransferase.
RNA (New York, N.Y.) 2006;12(8):1569-82.
2006: Tiina Wahlfors; Anne Karppinen; Juhani Jänne; Leena Alhonen; Jarmo Wahlfors
Polyamine depletion and cell cycle manipulation in combination with HSV thymidine kinase/ganciclovir cancer gene therapy.
International journal of oncology 2006;28(6):1515-22.
2006: Tiina Wahlfors; Tanja Hakkarainen; Juhani Jänne; Leena Alhonen; Jarmo Wahlfors
In vivo enhancement of herpes simplex virus thymidine kinase/ganciclovir cancer gene therapy with polyamine biosynthesis inhibition.
International journal of cancer. Journal international du cancer 2006;118(11):2907-10.
2006: Aki Järvinen; Tuomo A Keinänen; Nikolay Grigorenko; Alex R Khomutov; Anne Uimari; Jouko Vepsäläinen; Ale Närvänen; Leena Alhonen; Juhani Jänne
Guide molecule-driven stereospecific degradation of alpha-methylpolyamines by polyamine oxidase.
The Journal of biological chemistry 2006;281(8):4589-95.
2006: Juhani Jänne; Leena Alhonen; Marko Pietilä; Tuomo A Keinänen; Anne Uimari; Mervi T Hyvönen; Eija Pirinen; Aki Järvinen
Genetic manipulation of polyamine catabolism in rodents.
Journal of biochemistry 2006;139(2):155-60.
2006: Aki Järvinen; Marc Cerrada-Gimenez; Nikolay Grigorenko; Alex R Khomutov; Jouko Vepsäläinen; Riitta Sinervirta; Tuomo A Keinänen; Leena Alhonen; Juhani Jänne
Alpha-methyl polyamines: efficient synthesis and tolerance studies in vivo and in vitro. First evidence for dormant stereospecificity of polyamine oxidase.
Journal of medicinal chemistry 2006;49(1):399-406.
2006: Pia Leppänen; Ivana Kholová; Anssi J Mähönen; Kari J Airenne; Suvi Koota; Hannu Mansukoski; Johanna Närväinen; Maria Wirzenius; Leena Alhonen; Juhani Jänne; Kari Alitalo; Seppo Ylä-Herttuala
Short and long-term effects of hVEGF-A(165) in Cre-activated transgenic mice.
PloS one 2006;1():e13.
2006: Mervi T Hyvönen; Karl-Heinz Herzig; Riitta Sinervirta; Elke Albrecht; Isto Nordback; Juhani Sand; Tuomo A Keinänen; Jouko Vepsäläinen; Nikolay Grigorenko; Alex R Khomutov; Burkhard Krüger; Juhani Jänne; Leena Alhonen
activated polyamine catabolism in acute pancreatitis: alpha-methylated polyamine analogues prevent trypsinogen activation and pancreatitis-associated mortality.
The American journal of pathology 2006;168(1):115-22.
2005: Juhani Jänne; Leena Alhonen; Tuomo A Keinänen; Marko Pietilä; Anne Uimari; Eija Pirinen; Mervi T Hyvönen; Aki Järvinen
Animal disease models generated by genetic engineering of polyamine metabolism.
Journal of cellular and molecular medicine 2005;9(4):865-82.
2005: Jody M Tucker; John T Murphy; Nicholas Kisiel; Paula Diegelman; Karen W Barbour; Celestia Davis; Moussumi Medda; Leena Alhonen; Juhani Jänne; Debora L Kramer; Carl W Porter; Franklin G Berger
Potent modulation of intestinal tumorigenesis in Apcmin/+ mice by the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase.
Cancer research 2005;65(12):5390-8.
2005: Marko Pietilä; Eija Pirinen; Salla Keskitalo; Sisko Juutinen; Sanna Pasonen-Seppänen; Tuomo A Keinänen; Leena Alhonen; Juhani Jänne
Disturbed keratinocyte differentiation in transgenic mice and organotypic keratinocyte cultures as a result of spermidine/spermine N-acetyltransferase overexpression.
The Journal of investigative dermatology 2005;124(3):596-601.
2005: Aki Järvinen; Nikolay Grigorenko; Alex R Khomutov; Mervi T Hyvönen; Anne Uimari; Jouko Vepsäläinen; Riitta Sinervirta; Tuomo A Keinänen; Slavoljub Vujcic; Leena Alhonen; Carl W Porter; Juhani Jänne
Metabolic stability of alpha-methylated polyamine derivatives and their use as substitutes for the natural polyamines.
The Journal of biological chemistry 2005;280(8):6595-601.
2004: Selma K Kaasinen; Mari Oksman; Leena Alhonen; Heikki Tanila; Juhani Jänne
Spermidine/spermine N1-acetyltransferase overexpression in mice induces hypoactivity and spatial learning impairment.
Pharmacology, biochemistry, and behavior 2004;78(1):35-45.
2004: Juhani Jänne; Leena Alhonen; Marko Pietilä; Tuomo A Keinänen
Genetic approaches to the cellular functions of polyamines in mammals.
European journal of biochemistry / FEBS 2004;271(5):877-94.
2004: Eija Pirinen; Sami Heikkinen; Mari Malkki; Samir S Deeb; Juhani Jänne; Markku Laakso
Analysis of the human hexokinase II promoter in vivo: lack of insulin response within 4.0 kb.
Biochimica et biophysica acta 2004;1676(2):149-54.
2003: Jingdong Shan; Katja Porvari; Anne Kivinen; Lila Patrikainen; Maria Halmekytö; Juhani Jänne; Pirkko Vihko
Tissue-specific expression of the prostatic acid phosphatase promoter constructs.
Biochemical and biophysical research communications 2003;311(4):864-9.
2003: Selma K Kaasinen; Olli H J Gröhn; Tuomo A Keinänen; Leena Alhonen; Juhani Jänne
Overexpression of spermidine/spermine N1-acetyltransferase elevates the threshold to pentylenetetrazol-induced seizure activity in transgenic mice.
Experimental neurology 2003;183(2):645-52.
2003: T L Räsänen; Leena Alhonen; Riitta Sinervirta; Anne Uimari; K Kaasinen; Tuomo A Keinänen; Karl-Heinz Herzig; Juhani Jänne
Gossypol activates pancreatic polyamine catabolism in normal rats and induces acute pancreatitis in transgenic rats over-expressing spermidine/spermine N1-acetyltransferase.
Scandinavian journal of gastroenterology 2003;38(7):787-93.
2003: Tiina Wahlfors; Anne Karppinen; Leena Alhonen; Juhani Jänne; Jarmo Wahlfors
Polyamine biosynthesis inhibition enhances HSV-1 thymidine kinase/ganciclovir-mediated cytotoxicity in tumor cells.
International journal of cancer. Journal international du cancer 2003;104(3):380-8.
2002: Kirsi Niiranen; Marko Pietilä; Tuula Pirttilä; Aki Järvinen; Maria Halmekytö; Veli-Pekka Korhonen; Tuomo A Keinänen; Leena Alhonen; Juhani Jänne
Targeted disruption of spermidine/spermine N1-acetyltransferase gene in mouse embryonic stem cells. Effects on polyamine homeostasis and sensitivity to polyamine analogues.
The Journal of biological chemistry 2002;277(28):25323-8.
2002: Selma K Kaasinen; Gundars Goldsteins; Leena Alhonen; Juhani Jänne; Jari Koistinaho
Induction and activation of protein kinase C delta in hippocampus and cortex after kainic acid treatment.
Experimental neurology 2002;176(1):203-12.
2002: Timo Heikki Kumlin; Päivi Heikkinen; Veli-Matti Kosma; Leena Alhonen; Juhani Jänne; Jukka Juutilainen
p53-independent apoptosis in UV-irradiated mouse skin: possible inhibition by 50 Hz magnetic fields.
Radiation and environmental biophysics 2002;41(2):155-8.
2002: Zhi-He Gao; Suvikki Suppola; Jianqi Liu; Päivi Heikkilä; Juhani Jänne; Raimo Voutilainen
Association of H19 promoter methylation with the expression of H19 and IGF-II genes in adrenocortical tumors.
The Journal of clinical endocrinology and metabolism 2002;87(3):1170-6.
2002: Leena Alhonen; Tiina-Liisa Räsänen; Riitta Sinervirta; Jyrki Parkkinen; Veli-Pekka Korhonen; Marko Pietilä; Juhani Jänne
Polyamines are required for the initiation of rat liver regeneration.
The Biochemical journal 2002;362(Pt 1):149-53.
2001: Suvikki Suppola; Sami Heikkinen; Jyrki Parkkinen; Mikko Uusi-Oukari; Veli-Pekka Korhonen; Tuomo A Keinänen; Leena Alhonen; Juhani Jänne
Concurrent overexpression of ornithine decarboxylase and spermidine/spermine N(1)-acetyltransferase further accelerates the catabolism of hepatic polyamines in transgenic mice.
The Biochemical journal 2001;358(Pt 2):343-8.
2001: Marko Pietilä; Jyrki Parkkinen; Leena Alhonen; Juhani Jänne
Relation of skin polyamines to the hairless phenotype in transgenic mice overexpressing spermidine/spermine N-acetyltransferase.
The Journal of investigative dermatology 2001;116(5):801-5.
2001: AP Bras; Juhani Jänne; Carl W Porter; Daniel S Sitar
Spermidine/spermine n(1)-acetyltransferase catalyzes amantadine acetylation.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(5):676-80.
2001: Sami Loimas; Marjo-Riitta Toppinen; T Visakorpi; Juhani Jänne; Jarmo Wahlfors
Human prostate carcinoma cells as targets for herpes simplex virus thymidine kinase-mediated suicide gene therapy.
Cancer gene therapy 2001;8(2):137-44.
2001: Veli-Pekka Korhonen; Kirsi Niiranen; Maria Halmekytö; Marko Pietilä; Paula Diegelman; Jyrki Parkkinen; T Eloranta; Carl W Porter; Leena Alhonen; Juhani Jänne
Spermine deficiency resulting from targeted disruption of the spermine synthase gene in embryonic stem cells leads to enhanced sensitivity to antiproliferative drugs.
Molecular pharmacology 2001;59(2):231-8.
2000: Kimmo Mäkinen; Sami Loimas; Jarmo Wahlfors; Esko Alhava; Juhani Jänne
Evaluation of herpes simplex thymidine kinase mediated gene therapy in experimental pancreatic cancer.
The journal of gene medicine 2000;2(5):361-7.
2000: Leena Alhonen; Jyrki Parkkinen; Tuomo Keinanen; Riitta Sinervirta; Karl-Heinz Herzig; Juhani Jänne
Activation of polyamine catabolism in transgenic rats induces acute pancreatitis.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(15):8290-5.
2000: Anu-Maaria Sandmair; Mikko P Turunen; Kristiina Tyynelä; Sami Loimas; Pauli Vainio; Ritva Vanninen; Matti Vapalahti; R Bjerkvig; Juhani Jänne; Seppo Ylä-Herttuala
Herpes simplex virus thymidine kinase gene therapy in experimental rat BT4C glioma model: effect of the percentage of thymidine kinase-positive glioma cells on treatment effect, survival time, and tissue reactions.
Cancer gene therapy 2000;7(3):413-21.
2000: K Kaasinen; Jari Koistinaho; Leena Alhonen; Juhani Jänne
Overexpression of spermidine/spermine N-acetyltransferase in transgenic mice protects the animals from kainate-induced toxicity.
The European journal of neuroscience 2000;12(2):540-8.
2000: Sami Heikkinen; Suvikki Suppola; Mari Malkki; Samir S Deeb; Juhani Jänne; Markku Laakso
Mouse hexokinase II gene: structure, cDNA, promoter analysis, and expression pattern.
Mammalian genome : official journal of the International Mammalian Genome Society 2000;11(2):91-6.
2000: Kimmo Mäkinen; Sami Loimas; Veli-Matti Kosma; Jarmo Wahlfors; Seppo Ylä-Herttuala; Esko Alhava; Juhani Jänne
Adenovirus-mediated gene transfer into an experimental pancreatic tumour.
Annales chirurgiae et gynaecologiae 2000;89(2):99-103.
1999: Mikko O Laukkanen; S Mannermaa; Mikko O Hiltunen; S Aittomäki; Kari J Airenne; Juhani Jänne; Seppo Ylä-Herttuala
Local hypomethylation in atherosclerosis found in rabbit ec-sod gene.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(9):2171-8.
1999: Sami Heikkinen; Marko Pietilä; Maria Halmekytö; Suvikki Suppola; Eija Pirinen; Samir S Deeb; Juhani Jänne; Markku Laakso
Hexokinase II-deficient mice. Prenatal death of homozygotes without disturbances in glucose tolerance in heterozygotes.
The Journal of biological chemistry 1999;274(32):22517-23.
1999: S Lang; M Marchesani; Kristina Servomaa; L Kauppinen; Juhani Jänne; Tapio Rytömaa; R Wells; M Lun; M M Elkind
p53 gene mutations in neoplastic transformation of C3H 10T1/2 and severe combined immunodeficiency fibroblasts.
Mutation research 1999;434(1):61-5.
1999: Jouko Lukkarinen; Olli H J Gröhn; Leena Alhonen; Juhani Jänne; Risto A Kauppinen
Enhanced ornithine decarboxylase activity is associated with attenuated rate of damage evolution and reduction of infarct volume in transient middle cerebral artery occlusion in the rat.
Brain research 1999;826(2):325-9.
1999: Leena Alhonen; Marko Pietilä; Maria Halmekytö; Debora L Kramer; Juhani Jänne; Carl W Porter
Transgenic mice with activated polyamine catabolism due to overexpression of spermidine/spermine N1-acetyltransferase show enhanced sensitivity to the polyamine analog, N1, N11-diethylnorspermine.
Molecular pharmacology 1999;55(4):693-8.
1999: Suvikki Suppola; Marko Pietilä; Jyrki Parkkinen; Veli-Pekka Korhonen; Leena Alhonen; Maria Halmekytö; Carl W Porter; Juhani Jänne
Overexpression of spermidine/spermine N1-acetyltransferase under the control of mouse metallothionein I promoter in transgenic mice: evidence for a striking post-transcriptional regulation of transgene expression by a polyamine analogue.
The Biochemical journal 1999;338 ( Pt 2)():311-6.
1998: Jouko Lukkarinen; Risto A Kauppinen; Olli H J Gröhn; JM Oja; Riitta Sinervirta; Aki Järvinen; Leena Alhonen; Juhani Jänne
Neuroprotective role of ornithine decarboxylase activation in transient focal cerebral ischaemia: a study using ornithine decarboxylase-overexpressing transgenic rats.
The European journal of neuroscience 1998;10(6):2046-55.
1998: Juha Hyttinen; Veli-Pekka Korhonen; Mikko O Hiltunen; S Myöhänen; Juhani Jänne
High-level expression of bovine beta-lactoglobulin gene in transgenic mice.
Journal of biotechnology 1998;61(3):191-8.
1998: Sami Loimas; Jarmo Wahlfors; Juhani Jänne
Herpes simplex virus thymidine kinase-green fluorescent protein fusion gene: new tool for gene transfer studies and gene therapy.
BioTechniques 1998;24(4):614-8.
1998: Raimo Pussinen; Jouni Sirviö; Leena Alhonen; John Larson; Maria Halmekytö; Esa H Koivisto; Juhani Jänne
Preserved induction of long-term potentiation in the stratum radiatum in the CA1 field of hippocampal slices from transgenic mice overexpressing ornithine decarboxylase and overproducing putrescine.
Synapse (New York, N.Y.) 1998;28(4):288-93.
1998: Leena Alhonen; Anne Karppinen; Mikko Uusi-Oukari; Slavoljub Vujcic; Veli-Pekka Korhonen; Maria Halmekytö; Debora L Kramer; R Hines; Juhani Jänne; Carl W Porter
Correlation of polyamine and growth responses to N1,N11-diethylnorspermine in primary fetal fibroblasts derived from transgenic mice overexpressing spermidine/spermine N1-acetyltransferase.
The Journal of biological chemistry 1998;273(4):1964-9.
1998: Juhani Jänne; Leena Alhonen; Juha Hyttinen; T Peura; M Tolvanen; Veli-Pekka Korhonen
Transgenic bioreactors.
Biotechnology annual review 1998;4():55-74.
1998: Timo Heikki Kumlin; Leena Alhonen; Juhani Jänne; S Lang; Veli-Matti Kosma; Jukka Juutilainen
Epidermal ornithine decarboxylase and polyamines in mice exposed to 50 Hz magnetic fields and UV radiation.
Bioelectromagnetics 1998;19(6):388-91.
1998: Timo Heikki Kumlin; Veli-Matti Kosma; Leena Alhonen; Juhani Jänne; Hannu Komulainen; S Lang; Tapio Rytömaa; Kristina Servomaa; Jukka Juutilainen
Effects of 50 Hz magnetic fields on UV-induced skin tumourigenesis in ODC-transgenic and non-transgenic mice.
International journal of radiation biology 1998;73(1):113-21.
1997: Marko Pietilä; Leena Alhonen; Maria Halmekytö; P Kanter; Juhani Jänne; Carl W Porter
Activation of polyamine catabolism profoundly alters tissue polyamine pools and affects hair growth and female fertility in transgenic mice overexpressing spermidine/spermine N1-acetyltransferase.
The Journal of biological chemistry 1997;272(30):18746-51.
1997: Jukka H Meurman; Jarmo Wahlfors; Arja Korhonen; P Alakuijala; P Väisänen; H Torkko; Juhani Jänne
Identification of Bacteroides forsythus in subgingival dental plaque with the aid of a rapid PCR method.
Journal of dental research 1997;76(7):1376-80.
1997: Ritva Heljasvaara; I Veress; Maria Halmekytö; Leena Alhonen; Juhani Jänne; P Laajala; Antti Pajunen
Transgenic mice overexpressing ornithine and S-adenosylmethionine decarboxylases maintain a physiological polyamine homoeostasis in their tissues.
The Biochemical journal 1997;323 ( Pt 2)():457-62.
1997: Veli-Pekka Korhonen; M Tolvanen; Juha Hyttinen; Mikko Uusi-Oukari; Riitta Sinervirta; Leena Alhonen; M Jauhiainen; Olli A Jänne; Juhani Jänne
Expression of bovine beta-lactoglobulin/human erythropoietin fusion protein in the milk of transgenic mice and rabbits.
European journal of biochemistry / FEBS 1997;245(2):482-9.
1997: Mikko O Hiltunen; Leena Alhonen; J Koistinaho; S Myöhänen; Matti Pääkkönen; S Marin; Veli-Matti Kosma; Juhani Jänne
Hypermethylation of the APC (adenomatous polyposis coli) gene promoter region in human colorectal carcinoma.
International journal of cancer. Journal international du cancer 1997;70(6):644-8.
1997: Jouko Lukkarinen; Olli H J Gröhn; Riitta Sinervirta; Aki Järvinen; Risto A Kauppinen; Juhani Jänne; Leena Alhonen
Transgenic rats as models for studying the role of ornithine decarboxylase expression in permanent middle cerebral artery occlusion.
Stroke; a journal of cerebral circulation 1997;28(3):639-45.
1997: Mikko O Hiltunen; J Koistinaho; Leena Alhonen; S Myöhänen; S Marin; Veli-Matti Kosma; Matti Pääkkönen; Juhani Jänne
Hypermethylation of the WT1 and calcitonin gene promoter regions at chromosome 11p in human colorectal cancer.
British journal of cancer 1997;76(9):1124-30.
1997: Mikko Uusi-Oukari; Juha Hyttinen; Veli-Pekka Korhonen; A Västi; L Alhonen; Olli A Jänne; Juhani Jänne
Bovine alpha s1-casein gene sequences direct high level expression of human granulocyte-macrophage colony-stimulating factor in the milk of transgenic mice.
Transgenic research 1997;6(1):75-84.
1996: M Hakkarainen; Jarmo Wahlfors; S Myöhänen; M O Hiltunen; Matti Eskelinen; R Johansson; Juhani Jänne
Hypermethylation of calcitonin gene regulatory sequences in human breast cancer as revealed by genomic sequencing.
International journal of cancer. Journal international du cancer 1996;69(6):471-4.
1996: Mati Reeben; J Arbatova; J Palgi; Riitta Miettinen; Maria Halmekytö; Leena Alhonen; Juhani Jänne; PJ Riekkinen; Mart Saarma
Induced expression of neurotrophins in transgenic mice overexpressing ornithine decarboxylase and overproducing putrescine.
Journal of neuroscience research 1996;45(5):542-8.
1996: Leena Alhonen; Sami Heikkinen; Riitta Sinervirta; Maria Halmekytö; P Alakuijala; Juhani Jänne
Transgenic mice expressing the human ornithine decarboxylase gene under the control of mouse metallothionein I promoter.
The Biochemical journal 1996;314 ( Pt 2)():405-8.
1996: Juha Hyttinen; T Peura; M Tolvanen; J Aalto; Juhani Jänne
Detection of microinjected genes in bovine preimplantation embryos with combined DNA digestion and polymerase chain reaction.
Molecular reproduction and development 1996;43(2):150-7.
1995: Leena Alhonen; Maria Halmekytö; Veli-Matti Kosma; Jarmo Wahlfors; Risto A Kauppinen; Juhani Jänne
Life-long over-expression of ornithine decarboxylase (ODC) gene in transgenic mice does not lead to generally enhanced tumorigenesis or neuronal degeneration.
International journal of cancer. Journal international du cancer 1995;63(3):402-4.
1995: Jarmo Wahlfors; Jukka H Meurman; P Väisänen; P Alakuijala; Arja Korhonen; H Torkko; Juhani Jänne
Simultaneous detection of Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis by a rapid PCR method.
Journal of dental research 1995;74(11):1796-801.
1995: Veli-Pekka Korhonen; Maria Halmekytö; L Kauppinen; S Myöhänen; Jarmo Wahlfors; T Keinänen; T Hyvönen; Leena Alhonen; T Eloranta; Juhani Jänne
Molecular cloning of a cDNA encoding human spermine synthase.
DNA and cell biology 1995;14(10):841-7.
1995: Jarmo Wahlfors; Jukka H Meurman; J Toskala; Arja Korhonen; P Alakuijala; Esko Janatuinen; U M Kärkkkäinen; P Nuutinen; Juhani Jänne
Development of a rapid PCR method for identification of Helicobacter pylori in dental plaque and gastric biopsy specimens.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 1995;14(9):780-6.
1995: J Lukkarainen; Risto A Kauppinen; J Koistinaho; L M Alhonen; Juhani Jänne
Cerebral energy metabolism and immediate early gene induction following severe incomplete ischaemia in transgenic mice overexpressing the human ornithine decarboxylase gene: evidence that putrescine is not neurotoxic in vivo.
The European journal of neuroscience 1995;7(9):1840-9.
1995: J Korhonen; I Lahtinen; Maria Halmekytö; Leena Alhonen; Juhani Jänne; Daniel J Dumont; Kari Alitalo
Endothelial-specific gene expression directed by the tie gene promoter in vivo.
Blood 1995;86(5):1828-35.
1995: Jarmo Wahlfors; S Myöhänen; Veli-Pekka Korhonen; Leena Alhonen; Juhani Jänne
Long-term reduction of amplified ornithine decarboxylase sequences in human myeloma cells.
The Biochemical journal 1995;310 ( Pt 1)():299-303.
1995: T T Peura; M Tolvanen; Juha Hyttinen; Juhani Jänne
Effects of membrane piercing and the type of pronuclear injection fluid on development of in vitro-produced bovine embryos.
Theriogenology 1995;43(6):1087-96.
1994: Juhani Jänne; Juha Hyttinen; T Peura; M Tolvanen; Leena Alhonen; Riitta Sinervirta; Maria Halmekytö
Transgenic bioreactors.
The International journal of biochemistry 1994;26(7):859-70.
1994: Juha Hyttinen; T Peura; M Tolvanen; J Aalto; Leena Alhonen; Riitta Sinervirta; Maria Halmekytö; S Myöhänen; Juhani Jänne
Generation of transgenic dairy cattle from transgene-analyzed and sexed embryos produced in vitro.
Bio/technology (Nature Publishing Company) 1994;12(6):606-8.
1994: S Myöhänen; Jarmo Wahlfors; Juhani Jänne
Automated fluorescent genomic sequencing as applied to the methylation analysis of the human ornithine decarboxylase gene.
DNA sequence : the journal of DNA sequencing and mapping 1994;5(1):1-8.
1994: S Myöhänen; Jarmo Wahlfors; Leena Alhonen; Juhani Jänne
Nucleotide sequence of mouse spermidine synthase cDNA.
DNA sequence : the journal of DNA sequencing and mapping 1994;4(5):343-6.
1993: Toivo Halonen; Juhani Sivenius; Riitta Miettinen; Maria Halmekytö; Risto A Kauppinen; Riitta Sinervirta; L Alakuijala; Leena Alhonen; E MacDonald; Juhani Jänne
Elevated seizure threshold and impaired spatial learning in transgenic mice with putrescine overproduction in the brain.
The European journal of neuroscience 1993;5(9):1233-9.
1993: L Kauppinen; S Myöhänen; Maria Halmekytö; Leena Alhonen; Juhani Jänne
Transgenic mice over-expressing the human spermidine synthase gene.
The Biochemical journal 1993;293 ( Pt 2)():513-6.
1993: Maria Halmekytö; Juha Hyttinen; Riitta Sinervirta; Pia Leppänen; Juhani Jänne; Leena Alhonen
Regulation of the expression of human ornithine decarboxylase gene and ornithine decarboxylase promoter-driven reporter gene in transgenic mice.
The Biochemical journal 1993;292 ( Pt 3)():927-32.
1993: Mati Reeben; Maria Halmekytö; Leena Alhonen; Riitta Sinervirta; Mart Saarma; Juhani Jänne
Tissue-specific expression of rat light neurofilament promoter-driven reporter gene in transgenic mice.
Biochemical and biophysical research communications 1993;192(2):465-70.
1993: Maria Halmekytö; Leena Alhonen; L Alakuijala; Juhani Jänne
Transgenic mice over-producing putrescine in their tissues do not convert the diamine into higher polyamines.
The Biochemical journal 1993;291 ( Pt 2)():505-8.
1993: Helmut Mett; J Stanek; J A Lopez-Ballester; Juhani Jänne; Leena Alhonen; Riitta Sinervirta; Joerg Frei; U Regenass
Pharmacological properties of the ornithine decarboxylase inhibitor 3-aminooxy-1-propanamine and several structural analogues.
Cancer chemotherapy and pharmacology 1993;32(1):39-45.
1992: Jarmo Wahlfors; H Hiltunen; Kirsti Heinonen; Esa Hämäläinen; Leena Alhonen; Juhani Jänne
Genomic hypomethylation in human chronic lymphocytic leukemia.
Blood 1992;80(8):2074-80.
1992: Maria Halmekytö; Kari Syrjänen; Juhani Jänne; Leena Alhonen
Enhanced papilloma formation in response to skin tumor promotion in transgenic mice overexpressing the human ornithine decarboxylase gene.
Biochemical and biophysical research communications 1992;187(1):493-7.
1992: Juhani Jänne; Juha Hyttinen; T Peura; M Tolvanen; Leena Alhonen; Maria Halmekytö
Transgenic animals as bioproducers of therapeutic proteins.
Annals of medicine 1992;24(4):273-80.
1992: Risto A Kauppinen; Maria Halmekytö; Leena Alhonen; Juhani Jänne
Nuclear magnetic resonance spectroscopy study on energy metabolism, intracellular pH, and free Mg2+ concentration in the brain of transgenic mice overexpressing human ornithine decarboxylase gene.
Journal of neurochemistry 1992;58(3):831-6.
1991: Maria Halmekytö; Leena Alhonen; Jarmo Wahlfors; Riitta Sinervirta; Olli A Jänne; Juhani Jänne
Position-independent, aberrant expression of the human ornithine decarboxylase gene in transgenic mice.
Biochemical and biophysical research communications 1991;180(1):262-7.
1991: Maria Halmekytö; Leena Alhonen; Jarmo Wahlfors; Riitta Sinervirta; T Eloranta; Juhani Jänne
Characterization of a transgenic mouse line over-expressing the human ornithine decarboxylase gene.
The Biochemical journal 1991;278 ( Pt 3)():895-8.
1991: I M Hyttinen; Maria Halmekytö; Leena Alhonen; Juhani Jänne
Levels of ornithine decarboxylase genomic sequences, heterogeneous nuclear RNA and mRNA in human myeloma cells resistant to alpha-difluoromethylornithine.
The Biochemical journal 1991;278 ( Pt 3)():871-4.
1991: Juhani Jänne; Leena Alhonen; P Leinonen
Polyamines: from molecular biology to clinical applications.
Annals of medicine 1991;23(3):241-59.
1991: S Myöhänen; L Kauppinen; Jarmo Wahlfors; Leena Alhonen; Juhani Jänne
Human spermidine synthase gene: structure and chromosomal localization.
DNA and cell biology 1991;10(6):467-74.
1991: M Kolmer; T Ord; Leena Alhonen; Juha Hyttinen; Mart Saarma; R Villems; Juhani Jänne
Assignment of human prochymosin pseudogene to chromosome 1.
Genomics 1991;10(2):496-8.
1991: T Ord; M Kolmer; Juhani Jänne; R Villems; Mart Saarma
Structure and chromosomal localization of the human prochymosin pseudogene.
Advances in experimental medicine and biology 1991;306():121-6.
1991: T Peura; Juha Hyttinen; M Turunen; J Aalto; V Rainio; Juhani Jänne
Birth of calves developed from embryos of predetermined sex.
Acta veterinaria Scandinavica 1991;32(2):283-6.
1990: Jarmo Wahlfors; Leena Alhonen; L Kauppinen; T Hyvönen; Juhani Jänne; T O Eloranta
Human spermidine synthase: cloning and primary structure.
DNA and cell biology 1990;9(2):103-10.
1989: Erkki Hölttä; A Hirvonen; Jarmo Wahlfors; Leena Alhonen; Juhani Jänne; A Kallio
Human ornithine decarboxylase(ODC)-encoding gene: cloning and expression in ODC-deficient CHO cells.
Gene 1989;83(1):125-35.
1989: Maria Halmekytö; A Hirvonen; Jarmo Wahlfors; Leena Alhonen; Juhani Jänne
Methylation of human ornithine decarboxylase gene before transfection abolishes its transient expression in Chinese hamster ovary cells.
Biochemical and biophysical research communications 1989;162(1):528-34.
1989: A Hirvonen; T Eloranta; T Hyvönen; Leena Alhonen; Juhani Jänne
Characterization of difluoromethylornithine-resistant mouse and human tumour cell lines.
The Biochemical journal 1989;258(3):709-13.
1989: Juhani Jänne; Leena Alhonen; A Hirvonen; Jarmo Wahlfors
Molecular genetics of ornithine decarboxylase in human tumor cells.
Advances in enzyme regulation 1989;28():81-91.
1988: V Lipsanen; P Leinonen; Leena Alhonen; Juhani Jänne
Hypomethylation of ornithine decarboxylase gene and erb-A1 oncogene in human chronic lymphatic leukemia.
Blood 1988;72(6):2042-4.
1988: K Polvinen; Riitta Sinervirta; Leena Alhonen; Juhani Jänne
Overproduction of ornithine decarboxylase confers an apparent growth advantage to mouse tumor cells.
Biochemical and biophysical research communications 1988;155(1):373-8.
1988: A Hirvonen; Tiina Immonen; P Leinonen; L Alhonen-Hongisto; Olli A Jänne; Juhani Jänne
Effect of dexamethasone on the activity and expression of ornithine decarboxylase in rat liver and thymus.
Biochimica et biophysica acta 1988;950(2):229-33.
1988: H Elo; I Mutikainen; L Alhonen-Hongisto; R Laine; Juhani Jänne
Diethylglyoxal bis(guanylhydrazone): a novel highly potent inhibitor of S-adenosylmethionine decarboxylase with promising properties for potential chemotherapeutic use.
Cancer letters 1988;41(1):21-30.
1988: T Eloranta; O Kajander; L Kauppinen; T Hyvönen; Annikka Linnala-Kankkunen; N Kalkkinen; M Kulomaa; Leena Alhonen; Juhani Jänne
Approaching the structures of mammalian propylamine transferases and their genes.
Advances in experimental medicine and biology 1988;250():117-26.
1988: Juhani Jänne; Leena Alhonen; A Hirvonen; Jarmo Wahlfors; Riitta Sinervirta; T Eloranta; Erkki Hölttä; A Kallio
Structure, amplification and methylation of ornithine decarboxylase genes in human malignant cells.
Advances in experimental medicine and biology 1988;250():253-60.
1987: L Alhonen-Hongisto; A Hirvonen; Riitta Sinervirta; Juhani Jänne
Cadaverine supplementation during a chronic exposure to difluoromethylornithine allows an overexpression, but prevents gene amplification, of ornithine decarboxylase in L1210 mouse leukaemia cells.
The Biochemical journal 1987;247(3):651-5.
1987: P Leinonen; L Alhonen-Hongisto; R Laine; Olli A Jänne; Juhani Jänne
Chronic exposure to dexamethasone induces hypomethylation of ornithine decarboxylase genes in a human myeloma cell line.
FEBS letters 1987;215(1):68-72.
1987: L Alhonen-Hongisto; P Leinonen; R Laine; Juhani Jänne
Human myeloma cells acquire resistance to difluoromethylornithine without overproducing ornithine decarboxylase.
Biochemical and biophysical research communications 1987;144(1):132-7.
1987: P Leinonen; L Alhonen-Hongisto; R Laine; Olli A Jänne; Juhani Jänne
Human myeloma cells acquire resistance to difluoromethylornithine by amplification of ornithine decarboxylase gene.
The Biochemical journal 1987;242(1):199-203.
1987: L Alhonen-Hongisto; P Leinonen; Riitta Sinervirta; R Laine; R Winqvist; Kari Alitalo; Olli A Jänne; Juhani Jänne
Mouse and human ornithine decarboxylase genes. Methylation polymorphism and amplification.
The Biochemical journal 1987;242(1):205-10.
1986: H Elo; I Mutikainen; L Alhonen-Hongisto; R Laine; Juhani Jänne; P Lumme
Biochemical properties and crystal structure of ethylmethylglyoxal bis(guanylhydrazone) sulfate--an extremely powerful novel inhibitor of adenosylmethionine decarboxylase.
Zeitschrift für Naturforschung. C, Journal of biosciences 1986;41(9-10):851-5.
1986: R Winqvist; Tomi Mäkelä; P Seppänen; Olli A Jänne; L Alhonen-Hongisto; Juhani Jänne; K H Grzeschik; Kari Alitalo
Human ornithine decarboxylase sequences map to chromosome regions 2pter----p23 and 7cen----qter but are not coamplified with the NMYC oncogene.
Cytogenetics and cell genetics 1986;42(3):133-40.
1985: L Alhonen-Hongisto; Riitta Sinervirta; Olli A Jänne; Juhani Jänne
Gene expression of ornithine decarboxylase in L1210 leukaemia cells exposed to DL-2-difluoromethylornithine in the presence of cadaverine.
The Biochemical journal 1985;232(2):605-7.
1985: H Elo; R Laine; L Alhonen-Hongisto; Juhani Jänne; I Mutikainen; P Lumme
Biochemical characterization of propylglyoxal bis(guanylhydrazone). Facile synthesis of monoalkylglyoxal bis(guanylhydrazones).
Zeitschrift für Naturforschung. Section C: Biosciences 1985;40(11-12):839-42.
1985: P Nikula; L Alhonen-Hongisto; Juhani Jänne
Effects of bis(guanylhydrazones) on the activity and expression of ornithine decarboxylase.
The Biochemical journal 1985;231(1):213-6.
1985: L Alhonen-Hongisto; A Kallio; Riitta Sinervirta; Olli A Jänne; C G Gahmberg; Juhani Jänne
Tumourigenicity, cell-surface glycoprotein changes and ornithine decarboxylase gene pattern in Ehrlich ascites-carcinoma cells.
The Biochemical journal 1985;229(3):711-5.
1985: P Nikula; T. Hannele Ruohola-Baker; L Alhonen-Hongisto; Juhani Jänne
Carnitine prevents the early mitochondrial damage induced by methylglyoxal bis(guanylhydrazone) in L1210 leukaemia cells.
The Biochemical journal 1985;228(2):513-6.
1985: L Alhonen-Hongisto; A Kallio; Riitta Sinervirta; P Seppänen; K K Kontula; Olli A Jänne; Juhani Jänne
Difluoromethylornithine-induced amplification of ornithine decarboxylase genes in Ehrlich ascites carcinoma cells.
Biochemical and biophysical research communications 1985;126(2):734-40.
1985: Juhani Jänne; L Alhonen-Hongisto; P Nikula; H Elo
S-adenosylmethionine decarboxylase as target of chemotherapy.
Advances in enzyme regulation 1985;24():125-39.
1984: R Fagerström; P Seppänen; Juhani Jänne
A rapid chemiluminescence-based method for the determination of total polyamines in biological samples.
Clinica chimica acta; international journal of clinical chemistry 1984;143(1):45-50.
1984: P Seppänen; R Fagerström; L Alhonen-Hongisto; H Elo; P Lumme; Juhani Jänne
Glyoxal bis(guanylhydrazone) as an inhibitor of polyamine biosynthesis in tumour cells.
The Biochemical journal 1984;221(2):483-8.
1984: L Alhonen-Hongisto; R Fagerström; R Laine; H Elo; Juhani Jänne
Different efflux rates may determine the cellular accumulation of various bis(guanylhydrazones).
The Biochemical journal 1984;221(1):273-6.
1984: K Käpyaho; A Kallio; Juhani Jänne
Differential effects of 2-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) on the testosterone-induced growth of ventral prostate and seminal vesicles of castrated rats.
The Biochemical journal 1984;219(3):811-7.
1984: P Nikula; L Alhonen-Hongisto; P Seppänen; Juhani Jänne
Inhibition of long-chain fatty acid oxidation by methylglyoxal bis(guanylhydrazone).
Biochemical and biophysical research communications 1984;120(1):9-14.
1983: P Seppänen; L Alhonen-Hongisto; Juhani Jänne
Combined use of 2-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) in normal and leukemia-bearing mice.
Cancer letters 1983;18(1):1-10.
1983: P Seppänen; L Alhonen-Hongisto; K Käpyaho; Juhani Jänne
Two enzyme inhibition assays for methylglyoxal bis(guanylhydrazone).
Methods in enzymology 1983;94():247-53.
1983: A Kallio; P Seppänen; L Alhonen-Hongisto; Juhani Jänne
Modulation of the tissue disposition of methylglyoxal bis(guanylhydrazone) in mice by polyamine depletion and by polyamine administration.
Cancer research 1983;43(1):324-7.
1983: Juhani Jänne; Erkki Hölttä; A Kallio; K Käpyaho
Role of polyamines and their antimetabolites in clinical medicine.
Special topics in endocrinology and metabolism 1983;5():227-93.
1982: L Alhonen-Hongisto; P Seppänen; Juhani Jänne
Methylglyoxal bis(guanylhydrazone) stimulates the cellular transport system of the polyamines.
FEBS letters 1982;145(2):182-6.
1982: P Seppänen; L Alhonen-Hongisto; Juhani Jänne; A Raina; T Eloranta
Indirect determination of methylglyoxal bis(guanylhydrazone) in leukocytes of leukemia patients.
Clinica chimica acta; international journal of clinical chemistry 1982;123(1-2):187-92.
1982: L Alhonen-Hongisto; P Seppänen; E Hölttä; Juhani Jänne
Replacement of natural polyamines by cadaverine and its aminopropyl derivatives in Ehrlich ascites carcinoma cells.
Biochemical and biophysical research communications 1982;106(2):291-7.
1981: Juhani Jänne; L Alhonen-Hongisto; P Seppänen; M Siimes
Use of polyamine antimetabolites in experimental tumours and in human leukemia.
Medical biology 1981;59(5-6):448-57.
1981: M Siimes; P Seppänen; L Alhonen-Hongisto; Juhani Jänne
Synergistic action of two polyamine antimetabolites leads to a rapid therapeutic response in childhood leukemia.
International journal of cancer. Journal international du cancer 1981;28(5):567-70.
1981: P Seppänen; L Alhonen-Hongisto; Juhani Jänne
Death of tumor cells in response to the use of a system of stimulated polyamine uptake from the transport of methylglyoxal bis(guanylhydrazone).
European journal of biochemistry / FEBS 1981;118(3):571-6.
1981: P Seppänen; L Alhonen-Hongisto; Juhani Jänne
Polyamine deprivation-induced enhanced uptake of methylglyoxal bis(guanylhydrazone) by tumor cells.
Biochimica et biophysica acta 1981;674(2):169-77.
1980: L Alhonen-Hongisto; P Seppänen; Juhani Jänne
Intracellular putrescine and spermidine deprivation induces increased uptake of the natural polyamines and methylglyoxal bis(guanylhydrazone).
The Biochemical journal 1980;192(3):941-5.
1980: P Seppänen; L Alhonen-Hongisto; M Siimes; Juhani Jänne
Quantitation of methylglyoxal bis(guanylhydrazone) in blood plasma and leukemia cells of patients receiving the drug.
International journal of cancer. Journal international du cancer 1980;26(5):571-6.
1980: P Seppänen; L Alhonen-Hongisto; Juhani Jänne
Relation of the antiproliferative action of methylglyoxal-bis(guanylhydrazone) to the natural polyamines.
European journal of biochemistry / FEBS 1980;110(1):7-12.
1980: P Seppänen; L Alhonen-Hongisto; H Pösö; Juhani Jänne
Sensitive enzymic determination of methylglyoxal bis(guanylhydrazone) in cultured cells and in animal tissues.
FEBS letters 1980;111(1):99-103.