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Aaron Janowsky

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Sacha Javor; Robert Johnson; Mitra Tadayoni-Rebek; Katherine Wolfrum; Aaron Janowsky; Julius Rebek
Formylated polyamines as peptidomimetics.
Dove J Keith; Katherine Wolfrum; Amy J Eshleman; Aaron Janowsky
Melittin initiates dopamine transporter internalization and recycling in transfected HEK-293 cells.
John R Cashman; Matt Cerny; Aaron Janowsky; Robert Johnson; Karl Okolotowicz; Marc R Azar
Substituted heteroaromatic compounds: effect on nicotine self-administration in rats.

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All Publications

2012: Sacha Javor; Robert Johnson; Mitra Tadayoni-Rebek; Katherine Wolfrum; Aaron Janowsky; Julius Rebek
Formylated polyamines as peptidomimetics.
Bioorganic & medicinal chemistry letters 2012;22(21):6580-2.
2012: Dove J Keith; Katherine Wolfrum; Amy J Eshleman; Aaron Janowsky
Melittin initiates dopamine transporter internalization and recycling in transfected HEK-293 cells.
European journal of pharmacology 2012;690(1-3):13-21.
2012: John R Cashman; Matt Cerny; Aaron Janowsky; Robert Johnson; Karl Okolotowicz; Marc R Azar
Substituted heteroaromatic compounds: effect on nicotine self-administration in rats.
Psychopharmacology 2012;221(4):637-48.
2011: Michael B Gatch; Aaron Janowsky; Michael J Forster; Amy J Eshleman
Abuse liability profile of three substituted tryptamines.
The Journal of pharmacology and experimental therapeutics 2011;338(1):280-9.
2009: J M Wheeler; C Reed; Sue Burkhart-Kasch; Na Li; Christopher L Cunningham; Aaron Janowsky; F H Franken; Kristine Wiren; J G Hashimoto; A C Scibelli; Tamara J Phillips
Genetically correlated effects of selective breeding for high and low methamphetamine consumption.
Genes, brain, and behavior 2009;8(8):758-71.
2009: Jane X Kelly; Martin J Smilkstein; Reto Brun; Sergio Wittlin; Roland A Cooper; Kristin D Lane; Aaron Janowsky; Robert A Johnson; Rozalia A Dodean; Rolf Winter; David J Hinrichs; Michael K Riscoe
Discovery of dual function acridones as a new antimalarial chemotype.
Nature 2009;459(7244):270-3.
2009: Troy Voelker; Haiji Xia; Keith Fandrick; Robert Johnson; Aaron Janowsky; John R Cashman
2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors.
Bioorganic & medicinal chemistry 2009;17(5):2047-68.
2009: John R Cashman; Troy Voelker; Robert Johnson; Aaron Janowsky
Stereoselective inhibition of serotonin re-uptake and phosphodiesterase by dual inhibitors as potential agents for depression.
Bioorganic & medicinal chemistry 2009;17(1):337-43.
2008: Clare J Wilhelm; Robert A Johnson; Amy J Eshleman; Aaron Janowsky
Lobeline effects on tonic and methamphetamine-induced dopamine release.
Biochemical pharmacology 2008;75(6):1411-5.
2008: Peter C Meltzer; Olga Kryatova; Duy-Phong Pham-Huu; Patrick Donovan; Aaron Janowsky
The synthesis of bivalent 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)-8-heterobicyclo[3.2.1]octanes as probes for proximal binding sites on the dopamine and serotonin transporters.
Bioorganic & medicinal chemistry 2008;16(4):1832-41.
2007: Jane Xu Kelly; Martin J Smilkstein; Roland A Cooper; Kristin D Lane; Robert A Johnson; Aaron Janowsky; Rozalia A Dodean; David J Hinrichs; Rolf Winter; Michael K Riscoe
Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum.
Antimicrobial agents and chemotherapy 2007;51(11):4133-40.
2007: Anthony Basile; Aaron Janowsky; Krystyna Golembiowska; Magdalena Kowalska; Eyal Tam; Morris J Benveniste; Piotr Popik; Agnieszka Nikiforuk; Martyna Krawczyk; Gabriel Nowak; Philip Krieter; Arnold S Lippa; Phil Skolnick; Elena Koustova
Characterization of the antinociceptive actions of bicifadine in models of acute, persistent, and chronic pain.
The Journal of pharmacology and experimental therapeutics 2007;321(3):1208-25.
2007: Mark Froimowitz; Yonghong Gu; Les A Dakin; Pamela M Nagafuji; Charles J Kelley; Damon Parrish; Jeffrey Deschamps; Aaron Janowsky
Slow-onset, long-duration, alkyl analogues of methylphenidate with enhanced selectivity for the dopamine transporter.
Journal of medicinal chemistry 2007;50(2):219-32.
2006: Piotr Popik; Martyna Krawczyk; Krystyna Golembiowska; Gabriel Nowak; Aaron Janowsky; Phil Skolnick; Arnold S Lippa; Anthony Basile
Pharmacological profile of the "triple" monoamine neurotransmitter uptake inhibitor, DOV 102,677.
Cellular and molecular neurobiology 2006;26(4-6):857-73.
2006: Clare J Wilhelm; Robert A Johnson; Amy J Eshleman; Aaron Janowsky
Hydrogen ion concentration differentiates effects of methamphetamine and dopamine on transporter-mediated efflux.
Journal of neurochemistry 2006;96(4):1149-59.
2004: Clare J Wilhelm; Robert A Johnson; Paul G Lysko; Amy J Eshleman; Aaron Janowsky
Effects of methamphetamine and lobeline on vesicular monoamine and dopamine transporter-mediated dopamine release in a cotransfected model system.
The Journal of pharmacology and experimental therapeutics 2004;310(3):1142-51.
2003: Seiichiro Shimazu; Hiroko Tsunekawa; Fumio Yoneda; Hiroshi Katsuki; Akinori Akaike; Aaron Janowsky
Transporter-mediated actions of R-(-)-1-(benzofuran-2-yl)-2-propylaminopentane.
European journal of pharmacology 2003;482(1-3):9-16.
2003: Phil Skolnick; Piotr Popik; Aaron Janowsky; Bernard Beer; Arnold S Lippa
"Broad spectrum" antidepressants: is more better for the treatment of depression?
Life sciences 2003;73(25):3175-9.
2003: Erik Messamore; William F Hoffman; Aaron Janowsky
The niacin skin flush abnormality in schizophrenia: a quantitative dose-response study.
Schizophrenia research 2003;62(3):251-8.
2003: Keith Fandrick; Xianqi Feng; Aaron Janowsky; Robert Johnson; John R Cashman
Bivalent biogenic amine reuptake inhibitors.
Bioorganic & medicinal chemistry letters 2003;13(13):2151-4.
2003: Xianqi Feng; Keith Fandrick; Robert Johnson; Aaron Janowsky; John R Cashman
Syntheses of 3-carbomethoxy-4-(aryl)piperidines and in vitro and in vivo pharmacological evaluation: identification of inhibitors of the human dopamine transporter.
Bioorganic & medicinal chemistry 2003;11(5):775-80.
2003: Nick Z Lu; Amy J Eshleman; Aaron Janowsky; Cynthia L Bethea
Ovarian steroid regulation of serotonin reuptake transporter (SERT) binding, distribution, and function in female macaques.
Molecular psychiatry 2003;8(3):353-60.
2003: Phil Skolnick; Piotr Popik; Aaron Janowsky; Bernard Beer; Arnold S Lippa
Antidepressant-like actions of DOV 21,947: a "triple" reuptake inhibitor.
European journal of pharmacology 2003;461(2-3):99-104.
2003: Jennifer M Loftis; Aaron Janowsky
The N-methyl-D-aspartate receptor subunit NR2B: localization, functional properties, regulation, and clinical implications.
Pharmacology & therapeutics 2003;97(1):55-85.
2002: Jennifer M Loftis; Aaron Janowsky
Cocaine treatment- and withdrawal-induced alterations in the expression and serine phosphorylation of the NR1 NMDA receptor subunit.
Psychopharmacology 2002;164(4):349-59.
2002: William J Houlihan; Lawrence Kelly; Jessica Pankuch; Judith Koletar; Leonard Brand; Aaron Janowsky; Theresa A Kopajtic
Mazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter.
Journal of medicinal chemistry 2002;45(19):4097-109.
2001: Aaron Janowsky; C Mah; Robert A Johnson; Christopher L Cunningham; Tamara J Phillips; John C Crabbe; Amy J Eshleman; John K Belknap
Mapping genes that regulate density of dopamine transporters and correlated behaviors in recombinant inbred mice.
The Journal of pharmacology and experimental therapeutics 2001;298(2):634-43.
2001: Aaron Janowsky; Kim A Neve; Amy J Eshleman
Uptake and release of neurotransmitters.
Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.] 2001;Chapter 7():Unit7.9.
2001: John N Mason; Amy J Eshleman; John K Belknap; John C Crabbe; Jennifer M Loftis; Tara A Macey; Aaron Janowsky
NMDA receptor subunit mRNA and protein expression in ethanol-withdrawal seizure-prone and -resistant mice.
Alcoholism, clinical and experimental research 2001;25(5):651-60.
2001: Amy J Eshleman; K Wolfrum; Deborah C Mash; K Christensen; Aaron Janowsky
Drug interactions with the dopamine transporter in cryopreserved human caudate.
The Journal of pharmacology and experimental therapeutics 2001;296(2):442-9.
2000: Jennifer M Loftis; Aaron Janowsky
Regulation of NMDA receptor subunits and nitric oxide synthase expression during cocaine withdrawal.
Journal of neurochemistry 2000;75(5):2040-50.
1999: J E Keen; R Khawaled; David L Farrens; Torben R Neelands; Andre F Rivard; Chris T Bond; Aaron Janowsky; Bernd Fakler; John P Adelman; James Maylie
Domains responsible for constitutive and Ca(2+)-dependent interactions between calmodulin and small conductance Ca(2+)-activated potassium channels.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(20):8830-8.
1999: David Pribnow; Teresa Johnson-Pais; Chris T Bond; J Keen; R A Johnson; Aaron Janowsky; Christopher Silvia; Mathew J Thayer; James Maylie; John P Adelman
Skeletal muscle and small-conductance calcium-activated potassium channels.
Muscle & nerve 1999;22(6):742-50.
1999: Amy J Eshleman; M Carmolli; Medhane G Cumbay; C R Martens; Kim A Neve; Aaron Janowsky
Characteristics of drug interactions with recombinant biogenic amine transporters expressed in the same cell type.
The Journal of pharmacology and experimental therapeutics 1999;289(2):877-85.
1999: JF Buckman; Charles K Meshul; Deborah A Finn; Aaron Janowsky
Glutamate uptake in mice bred for ethanol withdrawal severity.
Psychopharmacology 1999;143(2):174-82.
1999: John R Cashman; Y N Xiong; L Xu; Aaron Janowsky
N-oxygenation of amphetamine and methamphetamine by the human flavin-containing monooxygenase (form 3): role in bioactivation and detoxication.
The Journal of pharmacology and experimental therapeutics 1999;288(3):1251-60.
1998: Robert A Johnson; Amy J Eshleman; T Meyers; Kim A Neve; Aaron Janowsky
[3H]substrate- and cell-specific effects of uptake inhibitors on human dopamine and serotonin transporter-mediated efflux.
Synapse (New York, N.Y.) 1998;30(1):97-106.
1997: Y Fang; Aaron Janowsky; Oline K Ronnekleiv
Cocaine exposure in fetal rhesus monkey: consequences for dopamine D1- and D2-like receptor binding densities.
Brain research. Developmental brain research 1997;104(1-2):163-74.
1997: Amy J Eshleman; E Stewart; A K Evenson; John N Mason; Randy D Blakely; Aaron Janowsky; Kim A Neve
Metabolism of catecholamines by catechol-O-methyltransferase in cells expressing recombinant catecholamine transporters.
Journal of neurochemistry 1997;69(4):1459-66.
1996: Charles K Meshul; G L Bunker; J N Mason; C Allen; Aaron Janowsky
Effects of subchronic clozapine and haloperidol on striatal glutamatergic synapses.
Journal of neurochemistry 1996;67(5):1965-73.
1995: Amy J Eshleman; Rachael L Neve; Aaron Janowsky; Kim A Neve
Characterization of a recombinant human dopamine transporter in multiple cell lines.
The Journal of pharmacology and experimental therapeutics 1995;274(1):276-83.
1995: L A Carter; John K Belknap; John C Crabbe; Aaron Janowsky
Allosteric regulation of the N-methyl-D-aspartate receptor-linked ion channel complex and effects of ethanol in ethanol-withdrawal seizure-prone and -resistant mice.
Journal of neurochemistry 1995;64(1):213-9.
1994: Charles K Meshul; R K Stallbaumer; B Taylor; Aaron Janowsky
Haloperidol-induced morphological changes in striatum are associated with glutamate synapses.
Brain research 1994;648(2):181-95.
1994: Amy J Eshleman; R A Henningsen; Kim A Neve; Aaron Janowsky
Release of dopamine via the human transporter.
Molecular pharmacology 1994;45(2):312-6.
1992: Charles K Meshul; Aaron Janowsky; Daniel E Casey; R K Stallbaumer; B Taylor
Coadministration of haloperidol and SCH-23390 prevents the increase in "perforated" synapses due to either drug alone.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1992;7(4):285-93.
1992: Aaron Janowsky; Kim A Neve; John M (Mark) Kinzie; B Taylor; Tomas de Paulis; John K Belknap
Extrastriatal dopamine D2 receptors: distribution, pharmacological characterization and region-specific regulation by clozapine.
The Journal of pharmacology and experimental therapeutics 1992;261(3):1282-90.
1992: Charles K Meshul; Aaron Janowsky; Daniel E Casey; R K Stallbaumer; B Taylor
Effect of haloperidol and clozapine on the density of "perforated" synapses in caudate, nucleus accumbens, and medial prefrontal cortex.
Psychopharmacology 1992;106(1):45-52.
1991: Jeffrey N. Joyce; Aaron Janowsky; Kim A Neve
Characterization and distribution of [125I]epidepride binding to dopamine D2 receptors in basal ganglia and cortex of human brain.
The Journal of pharmacology and experimental therapeutics 1991;257(3):1253-63.
1991: Kim A Neve; Rachael L Neve; S Fidel; Aaron Janowsky; Gerry Higgins
Increased abundance of alternatively spliced forms of D2 dopamine receptor mRNA after denervation.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(7):2802-6.
1990: Kim A Neve; R A Henningsen; John M (Mark) Kinzie; Tomas de Paulis; Dennis E Schmidt; Robert M Kessler; Aaron Janowsky
Sodium-dependent isomerization of dopamine D-2 receptors characterized using [125I]epidepride, a high-affinity substituted benzamide ligand.
The Journal of pharmacology and experimental therapeutics 1990;252(3):1108-16.
1990: D A Davis; Tomas de Paulis; Aaron Janowsky; H E Smith
Chloro-substituted, sterically hindered 5,11-dicarbo analogues of clozapine as potential chiral antipsychotic agents.
Journal of medicinal chemistry 1990;33(2):809-14.
1989: I Angel; Aaron Janowsky; S M Paul
The effects of serotonergic and dopaminergic lesions on sodium-sensitive [3H]mazindol binding in rat hypothalamus and corpus striatum.
Brain research 1989;503(2):339-41.
1989: J H Rupard; Tomas de Paulis; Aaron Janowsky; H E Smith
Sterically hindered 5,11-dicarbo analogues of clozapine as potential chiral antipsychotic agents.
Journal of medicinal chemistry 1989;32(10):2261-8.
1988: Tomas de Paulis; Aaron Janowsky; Robert M Kessler; J A Clanton; H E Smith
(S)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-[125I]iodo- 2-methoxybenzamide hydrochloride, a new selective radioligand for dopamine D-2 receptors.
Journal of medicinal chemistry 1988;31(10):2027-33.
1988: Aaron Janowsky; Tomas de Paulis; J A Clanton; H E Smith; Michael H Ebert; Robert M Kessler
[125I]iodopride: a specific high affinity radioligand for labelling striatal dopamine D-2 receptors.
European journal of pharmacology 1988;150(1-2):203-5.
1988: R Labarca; John Thomas; M Koulu; Y S Kim; Aaron Janowsky; L Wilkinson; M Linnoila; S M Paul; DAVID PICKAR
A central 6-hydroxydopamine lesion prevents fluphenazine-induced increase in plasma homovanillic acid.
Brain research bulletin 1988;20(5):567-71.
1987: Aaron Janowsky; F Vocci; P Berger; I Angel; N Zelnik; J E Kleinman; P Skolnick; S M Paul
[3H]GBR-12935 binding to the dopamine transporter is decreased in the caudate nucleus in Parkinson's disease.
Journal of neurochemistry 1987;49(2):617-21.
1987: P J Conn; Aaron Janowsky; E Sanders-Bush
Denervation supersensitivity of 5-HT-1c receptors in rat choroid plexus.
Brain research 1987;400(2):396-8.
1987: G T Bolger; Anthony Basile; Aaron Janowsky; S M Paul; P Skolnick
Regulation of dihydropyridine calcium antagonist binding sites in the rat hippocampus following neurochemical lesions.
Journal of neuroscience research 1987;17(3):285-90.
1987: R Labarca; Aaron Janowsky; S M Paul
Neurotransmitter-stimulated inositol phosphate accumulation in hippocampal slices.
Methods in enzymology 1987;141():192-201.
1986: Aaron Janowsky; P Berger; F Vocci; R Labarca; P Skolnick; S M Paul
Characterization of sodium-dependent [3H]GBR-12935 binding in brain: a radioligand for selective labelling of the dopamine transport complex.
Journal of neurochemistry 1986;46(4):1272-6.
1986: R Hauger; B Hulihan-Giblin; I Angel; M D Luu; Aaron Janowsky; P Skolnick; S M Paul
Glucose regulates [3H](+)-amphetamine binding and Na+K+ ATPase activity in the hypothalamus: a proposed mechanism for the glucostatic control of feeding and satiety.
Brain research bulletin 1986;16(2):281-8.
1985: R Labarca; Aaron Janowsky; S M Paul
Manganese stimulates incorporation of [3H]inositol into an agonist-insensitive pool of phosphatidylinositol in brain membranes.
Biochemical and biophysical research communications 1985;132(2):540-7.
1985: M M Schweri; P Skolnick; M F Rafferty; K C Rice; Aaron Janowsky; S M Paul
[3H]Threo-(+/-)-methylphenidate binding to 3,4-dihydroxyphenylethylamine uptake sites in corpus striatum: correlation with the stimulant properties of ritalinic acid esters.
Journal of neurochemistry 1985;45(4):1062-70.
1985: B Hulihan-Giblin; R L Hauger; Aaron Janowsky; S M Paul
Dopaminergic denervation increases [3H](+)-amphetamine binding in the rat striatum.
European journal of pharmacology 1985;113(1):141-2.
1985: Aaron Janowsky; M M Schweri; P Berger; R Long; P Skolnick; S M Paul
The effects of surgical and chemical lesions on striatal [3H]threo-(+/-)-methylphenidate binding: correlation with [3H]dopamine uptake.
European journal of pharmacology 1985;108(2):187-91.
1985: P Berger; Aaron Janowsky; F Vocci; P Skolnick; M M Schweri; S M Paul
[3H]GBR-12935: a specific high affinity ligand for labeling the dopamine transport complex.
European journal of pharmacology 1985;107(2):289-90.
1984: Aaron Janowsky; R Labarca; S M Paul
Characterization of neurotransmitter receptor-mediated phosphatidylinositol hydrolysis in the rat hippocampus.
Life sciences 1984;35(19):1953-61.
1984: R Labarca; Aaron Janowsky; J Patel; S M Paul
Phorbol esters inhibit agonist-induced [3H] inositol-1-phosphate accumulation in rat hippocampal slices.
Biochemical and biophysical research communications 1984;123(2):703-9.
1984: Aaron Janowsky; R Labarca; S M Paul
Noradrenergic denervation increases alpha 1-adrenoceptor-mediated inositol-phosphate accumulation in the hippocampus.
European journal of pharmacology 1984;102(1):193-4.
1983: Fridolin Sulser; Aaron Janowsky; F Okada; D Hal Manier; P L Mobley
Regulation of recognition and action function of the norepinephrine (NE) receptor-coupled adenylate cyclase system in brain: implications for the therapy of depression.
Neuropharmacology 1983;22(3 Spec No):425-31.
1983: Fridolin Sulser; D Hal Manier; Aaron Janowsky; F Okada
Regulation of noradrenergic receptor systems in brain that are coupled to adenylate cyclase.
Journal of neural transmission. Supplementum 1983;18():121-30.
1982: D Hal Manier; F Okada; Aaron Janowsky; L R Steranka; Fridolin Sulser
Serotonergic denervation changes binding characteristics of beta-adrenoceptors in rat cortex.
European journal of pharmacology 1982;86(1):137-9.
1982: Aaron Janowsky; F Okada; D Hal Manier; C D Applegate; Fridolin Sulser; L R Steranka
Role of serotonergic input in the regulation of the beta-adrenergic receptor-coupled adenylate cyclase system.
Science (New York, N.Y.) 1982;218(4575):900-1.
1982: Aaron Janowsky; L R Steranka; D D Gillespie; Fridolin Sulser
Role of neuronal signal input in the down-regulation of central noradrenergic receptor function by antidepressant drugs.
Journal of neurochemistry 1982;39(1):290-2.
1982: Fridolin Sulser; Aaron Janowsky
Receptors, receptor sensitivity, and receptor regulation in the CNS.
Advances in biochemical psychopharmacology 1982;34():141-53.
1980: R Mishra; Aaron Janowsky; Fridolin Sulser
Action of mianserin and zimelidine on the norepinephrine receptor coupled adenylate cyclase system in brain: subsensitivity without reduction in beta-adrenergic receptor binding.
Neuropharmacology 1980;19(10):983-7.
1979: R Mishra; Aaron Janowsky; F Sulser
Subsensitivity of the norepinephrine receptor-coupled adenylate cyclase system in brain: effects of nisoxetine versus fluoxetine.
European journal of pharmacology 1979;60(4):379-82.
1978: J A Alhadeff; G Cimino; Aaron Janowsky
Isoenzymes of human liver alpha-L-fucosidase: chemical relationship, kinetic studies, and immunochemical characterization.
Molecular and cellular biochemistry 1978;19(3):171-80.
1978: J A Alhadeff; Aaron Janowsky
Human serum alpha-L-fucosidase.
Clinica chimica acta; international journal of clinical chemistry 1978;82(1-2):133-40.
1977: J A Alhadeff; G Cimino; Aaron Janowsky; J S O'Brien
Human liver glycoprotein sialyltransferase.
Biochimica et biophysica acta 1977;484(2):307-21.
1977: J A Alhadeff; Aaron Janowsky
Purification and properties of human brain alpha-L-fucosidase.
Journal of neurochemistry 1977;28(2):423-7.