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David Jans

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
11
Trapani, Joseph
11
Xiao, Chong-Yun
9
Jans, PJ
9
Loveland, Kate
8
Briggs, Lyndall
7
Forwood, Jade
7
Alvisi, Gualtiero
7
Wagstaff, Kylie
6
Chan, Chee-Kai
6
Ghildyal, Reena
6
Hübner, Stefan
6
Moseley, Gregory
5
Pouton, Colin
5
Hogarth, Cathryn
5
Bardin, Philip

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Publications

TOP 3
Moseley Gregory W; Lahaye Xavier; Roth Daniela M; Oksayan Sibil; Filmer Richard P; Rowe Caitlin L; Blondel Danielle; Jans David A
Dual modes of rabies P-protein association with microtubules: a novel strategy to suppress the antiviral response.
Wagstaff Kylie M; Jans David A
Importins and beyond: non-conventional nuclear transport mechanisms.
Glover Dominic J; Ng Su May; Mechler Adam; Martin Lisandra L; Jans David A
Multifunctional protein nanocarriers for targeted nuclear gene delivery in nondividing cells.

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All Publications

2009: Moseley Gregory W; Lahaye Xavier; Roth Daniela M; Oksayan Sibil; Filmer Richard P; Rowe Caitlin L; Blondel Danielle; Jans David A
Dual modes of rabies P-protein association with microtubules: a novel strategy to suppress the antiviral response.
Journal of cell science 2009;122(Pt 20):3652-62.
2009: Wagstaff Kylie M; Jans David A
Importins and beyond: non-conventional nuclear transport mechanisms.
Traffic (Copenhagen, Denmark) 2009;10(9):1188-98.
2009: Glover Dominic J; Ng Su May; Mechler Adam; Martin Lisandra L; Jans David A
Multifunctional protein nanocarriers for targeted nuclear gene delivery in nondividing cells.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(9):2996-3006.
2009: Roth Daniela M; Harper Ian; Pouton Colin W; Jans David A
Modulation of nucleocytoplasmic trafficking by retention in cytoplasm or nucleus.
Journal of cellular biochemistry 2009;107(6):1160-7.
2009: Itman Catherine; Small Chris; Griswold Michael; Nagaraja Ankur K; Matzuk Martin M; Brown Chester W; Jans David A; Loveland Kate L
Developmentally regulated SMAD2 and SMAD3 utilization directs activin signaling outcomes.
Developmental dynamics : an official publication of the American Association of Anatomists 2009;238(7):1688-700.
2009: Itman C; Miyamoto Y; Young J; Jans D A; Loveland K L
Nucleocytoplasmic transport as a driver of mammalian gametogenesis.
Seminars in cell & developmental biology 2009;20(5):607-19.
2009: Ghildyal Reena; Jordan Benjamin; Li Dongsheng; Dagher Hayat; Bardin Phillip G; Gern James E; Jans David A
Rhinovirus 3C protease can localize in the nucleus and alter active and passive nucleocytoplasmic transport.
Journal of virology 2009;83(14):7349-52.
2009: Ghildyal Reena; Ho Adeline; Dias Manisha; Soegiyono Lydia; Bardin Phillip G; Tran Kim C; Teng Michael N; Jans David A
The respiratory syncytial virus matrix protein possesses a Crm1-mediated nuclear export mechanism.
Journal of virology 2009;83(11):5353-62.
2009: Caly Leon; Jans David A; Piller Sabine C
Proteolytic cleavage of HIV-1 GFP-Vpr fusions at novel sites within virions and living cells: concerns for intracellular trafficking studies.
Journal of fluorescence 2009;19(3):567-73.
2008: Li Dongsheng; Jans David A; Bardin Phillip G; Meanger Jayesh; Mills John; Ghildyal Reena
Association of respiratory syncytial virus M protein with viral nucleocapsids is mediated by the M2-1 protein.
Journal of virology 2008;82(17):8863-70.
2008: Wagstaff Kylie M; Fan Jun Y; De Jesus Michelle A; Tremethick David J; Jans David A
Efficient gene delivery using reconstituted chromatin enhanced for nuclear targeting.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(7):2232-42.
2008: Fulcher Alex J; Ahmed Chulbul M I; Noon-Song Ezra N; Kwan Rain Y Q; Subramaniam Prem S; Johnson Howard M; Jans David A
Interferon gamma is recognised by importin alpha/beta: enhanced nuclear localising and transactivation activities of an interferon gamma mimetic.
FEBS letters 2008;582(11):1569-74.
2008: Ruddock-D'Cruz Nancy T; Prashadkumar Sivachelvi; Wilson Katrina J; Heffernan Corey; Cooney Melissa A; French Andrew J; Jans David A; Verma Paul J; Holland Michael K
Dynamic changes in localization of Chromobox (Cbx) family members during the maternal to embryonic transition.
Molecular reproduction and development 2008;75(3):477-88.
2008: Hearps Anna C; Wagstaff Kylie M; Piller Sabine C; Jans David A
The N-terminal basic domain of the HIV-1 matrix protein does not contain a conventional nuclear localization sequence but is required for DNA binding and protein self-association.
Biochemistry 2008;47(7):2199-210.
2008: Alvisi Gualtiero; Rawlinson Stephen M; Ghildyal Reena; Ripalti Alessandro; Jans David A
Regulated nucleocytoplasmic trafficking of viral gene products: a therapeutic target?
Biochimica et biophysica acta 2008;1784(1):213-27.
2008: Caly Leon; Saksena Nitin K; Piller Sabine C; Jans David A
Impaired nuclear import and viral incorporation of Vpr derived from a HIV long-term non-progressor.
Retrovirology 2008;5():67.
2007: Hearps Anna C; Pryor Melinda J; Kuusisto Henna V; Rawlinson Stephen M; Piller Sabine C; Jans David A
The biarsenical dye Lumio exhibits a reduced ability to specifically detect tetracysteine-containing proteins within live cells.
Journal of fluorescence 2007;17(6):593-7.
2007: Moseley Gregory W; Filmer Richard P; DeJesus Michelle A; Jans David A
Nucleocytoplasmic distribution of rabies virus P-protein is regulated by phosphorylation adjacent to C-terminal nuclear import and export signals.
Biochemistry 2007;46(43):12053-61.
2007: Wagstaff Kylie M; Jans David A
Nucleocytoplasmic transport of DNA: enhancing non-viral gene transfer.
The Biochemical journal 2007;406(2):185-202.
2007: Holt J E; Ly-Huynh J D; Efthymiadis A; Hime G R; Loveland K L; Jans D A
Regulation of Nuclear Import During Differentiation; The IMP alpha Gene Family and Spermatogenesis.
Current genomics 2007;8(5):323-34.
2007: Conway-Campbell Becky L; Wooh Jong Wei; Brooks Andrew J; Gordon David; Brown Richard J; Lichanska Agnieszka M; Chin Hong Soon; Barton Chenoa L; Boyle Glen M; Parsons Peter G; Jans David A; Waters Michael J
Nuclear targeting of the growth hormone receptor results in dysregulation of cell proliferation and tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(33):13331-6.
2007: Pouton Colin W; Wagstaff Kylie M; Roth Daniela M; Moseley Gregory W; Jans David A
Targeted delivery to the nucleus.
Advanced drug delivery reviews 2007;59(8):698-717.
2007: Hogarth Cathryn A; Jans David A; Loveland Kate L
Subcellular distribution of importins correlates with germ cell maturation.
Developmental dynamics : an official publication of the American Association of Anatomists 2007;236(8):2311-20.
2007: Alvisi Gualtiero; Musiani Daniele; Jans David A; Ripalti Alessandro
An importin alpha/beta-recognized bipartite nuclear localization signal mediates targeting of the human herpes simplex virus type 1 DNA polymerase catalytic subunit pUL30 to the nucleus.
Biochemistry 2007;46(32):9155-63.
2007: Moseley Gregory W; Roth Daniela Martino; DeJesus Michelle A; Leyton Denisse L; Filmer Richard P; Pouton Colin W; Jans David A
Dynein light chain association sequences can facilitate nuclear protein import.
Molecular biology of the cell 2007;18(8):3204-13.
2007: Pryor Melinda J; Rawlinson Stephen M; Butcher Rebecca E; Barton Chenoa L; Waterhouse Tracey A; Vasudevan Subhash G; Bardin Phillip G; Wright Peter J; Jans David A; Davidson Andrew D
Nuclear localization of dengue virus nonstructural protein 5 through its importin alpha/beta-recognized nuclear localization sequences is integral to viral infection.
Traffic (Copenhagen, Denmark) 2007;8(7):795-807.
2007: Roth Daniela Martino; Moseley Gregory W; Glover Dominic; Pouton Colin W; Jans David A
A microtubule-facilitated nuclear import pathway for cancer regulatory proteins.
Traffic (Copenhagen, Denmark) 2007;8(6):673-86.
2007: Wagstaff Kylie M; Glover Dominic J; Tremethick David J; Jans David A
Histone-mediated transduction as an efficient means for gene delivery.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(4):721-31.
2007: Hearps Anna C; Jans David A
Regulating the functions of the HIV-1 matrix protein.
AIDS research and human retroviruses 2007;23(3):341-6.
2007: Forwood Jade K; Kaur Gurpreet; Jans David A
Nuclear import properties of the sex-determining factor SRY.
Methods in molecular biology (Clifton, N.J.) 2007;390():83-97.
2006: Rawlinson Stephen M; Pryor Melinda J; Wright Peter J; Jans David A
Dengue virus RNA polymerase NS5: a potential therapeutic target?
Current drug targets 2006;7(12):1623-38.
2006: Goffin Laurence; Vodala Sadanand; Fraser Christine; Ryan Joanne; Timms Mark; Meusburger Sarina; Catimel Bruno; Nice Edouard C; Silver Pamela A; Xiao Chong-Yun; Jans David A; Gething Mary-Jane H
The unfolded protein response transducer Ire1p contains a nuclear localization sequence recognized by multiple beta importins.
Molecular biology of the cell 2006;17(12):5309-23.
2006: Alvisi Gualtiero; Ripalti Alessandro; Ngankeu Apollinaire; Giannandrea Maila; Caraffi Stefano G; Dias Manisha M; Jans David A
Human cytomegalovirus DNA polymerase catalytic subunit pUL54 possesses independently acting nuclear localization and ppUL44 binding motifs.
Traffic (Copenhagen, Denmark) 2006;7(10):1322-32.
2006: Ghildyal Reena; Ho Adeline; Jans David A
Central role of the respiratory syncytial virus matrix protein in infection.
FEMS microbiology reviews 2006;30(5):692-705.
2006: Hearps Anna C; Jans David A
HIV-1 integrase is capable of targeting DNA to the nucleus via an importin alpha/beta-dependent mechanism.
The Biochemical journal 2006;398(3):475-84.
2006: Forwood Jade K; Jans David A
Quantitative analysis of DNA-protein interactions using double-labeled native gel electrophoresis and fluorescence-based imaging.
Electrophoresis 2006;27(16):3166-70.
2006: Hübner S; Eam J E; Wagstaff K M; Jans D A
Quantitative analysis of localization and nuclear aggregate formation induced by GFP-lamin A mutant proteins in living HeLa cells.
Journal of cellular biochemistry 2006;98(4):810-26.
2006: Alvisi Gualtiero; Jans David A; Ripalti Alessandro
Human cytomegalovirus (HCMV) DNA polymerase processivity factor ppUL44 dimerizes in the cytosol before translocation to the nucleus.
Biochemistry 2006;45(22):6866-72.
2006: Alvisi Gualtiero; Poon Ivan K H; Jans David A
Tumor-specific nuclear targeting: promises for anti-cancer therapy?
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2006;9(1-2):40-50.
2006: Wagstaff Kylie M; Jans David A
Intramolecular masking of nuclear localization signals: analysis of importin binding using a novel AlphaScreen-based method.
Analytical biochemistry 2006;348(1):49-56.
2006: Hübner S; Eam J E; Hübner A; Jans D A
Laminopathy-inducing lamin A mutants can induce redistribution of lamin binding proteins into nuclear aggregates.
Experimental cell research 2006;312(2):171-83.
2006: Hogarth Cathryn A; Calanni Sophina; Jans David A; Loveland Kate L
Importin alpha mRNAs have distinct expression profiles during spermatogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists 2006;235(1):253-62.
2006: Loveland Kate L; Hogarth Cathryn; Szczepny Anette; Prabhu Sridurga Mithra; Jans David A
Expression of nuclear transport importins beta 1 and beta 3 is regulated during rodent spermatogenesis.
Biology of reproduction 2006;74(1):67-74.
2006: Pryor Melinda J; Rawlinson Stephen M; Wright Peter J; Jans David A
CRM1-dependent nuclear export of dengue virus type 2 NS5.
Novartis Foundation symposium 2006;277():149-61; discussion 161-3, 251-3.
2006: Wagstaff Kylie M; Jans David A
Protein transduction: cell penetrating peptides and their therapeutic applications.
Current medicinal chemistry 2006;13(12):1371-87.
2005: Loveland K L; Hogarth C; Mendis S; Efthymiadis A; Ly J; Itman C; Meachem S; Brown C W; Jans D A
Drivers of germ cell maturation.
Annals of the New York Academy of Sciences 2005;1061():173-82.
2005: Alvisi Gualtiero; Jans David A; Guo Jinjin; Pinna Lorenzo A; Ripalti Alessandro
A protein kinase CK2 site flanking the nuclear targeting signal enhances nuclear transport of human cytomegalovirus ppUL44.
Traffic (Copenhagen, Denmark) 2005;6(11):1002-13.
2005: Hogarth Cathryn; Itman Catherine; Jans David A; Loveland Kate L
Regulated nucleocytoplasmic transport in spermatogenesis: a driver of cellular differentiation?
BioEssays : news and reviews in molecular, cellular and developmental biology 2005;27(10):1011-25.
2005: Ghildyal Reena; Ho Adeline; Wagstaff Kylie M; Dias Manisha M; Barton Chenoa L; Jans Patricia; Bardin Phillip; Jans David A
Nuclear import of the respiratory syncytial virus matrix protein is mediated by importin beta1 independent of importin alpha.
Biochemistry 2005;44(38):12887-95.
2005: Martin F; Roth D M; Jans D A; Pouton C W; Partridge L J; Monk P N; Moseley G W
Tetraspanins in viral infections: a fundamental role in viral biology?
Journal of virology 2005;79(17):10839-51.
2005: Cali Leon; Wang Bin; Mikhail Meriet; Gill Michael J; Beckthold Brenda; Salemi Marco; Jans David A; Piller Sabine C; Saksena Nitin K
Evidence for host-driven selection of the HIV type 1 vpr gene in vivo during HIV disease progression in a transfusion-acquired cohort.
AIDS research and human retroviruses 2005;21(8):728-33.
2005: Poon Ivan K H; Oro Cristina; Dias Manisha M; Zhang Jingpu; Jans David A
Apoptin nuclear accumulation is modulated by a CRM1-recognized nuclear export signal that is active in normal but not in tumor cells.
Cancer research 2005;65(16):7059-64.
2005: Wagstaff Kylie M; Dias Manisha M; Alvisi Gualtiero; Jans David A
Quantitative analysis of protein-protein interactions by native page/fluorimaging.
Journal of fluorescence 2005;15(4):469-73.
2005: Hu Wei; Kemp Bruce E; Jans David A
Kinetic properties of nuclear transport conferred by the retinoblastoma (Rb) NLS.
Journal of cellular biochemistry 2005;95(4):782-93.
2005: Blink Elizabeth J; Jiansheng Zhou; Hu Wei; Calanni Sophina T; Trapani Joseph A; Bird Phillip I; Jans David A
Interaction of the nuclear localizing cytolytic granule serine protease granzyme B with importin alpha or beta: modulation by the serpin inhibitor PI-9.
Journal of cellular biochemistry 2005;95(3):598-610.
2005: Glover Dominic J; Lipps Hans J; Jans David A
Towards safe, non-viral therapeutic gene expression in humans.
Nature reviews. Genetics 2005;6(4):299-310.
2005: Poon Ivan K H; Jans David A
Regulation of nuclear transport: central role in development and transformation?
Traffic (Copenhagen, Denmark) 2005;6(3):173-86.
2005: Poon I K H; Oro C; Dias M M; Zhang J-P; Jans D A
A tumor cell-specific nuclear targeting signal within chicken anemia virus VP3/apoptin.
Journal of virology 2005;79(2):1339-41.
2005: Soboleva Tatiana A; Jans David A; Johnson-Saliba Melanie; Baker Rohan T
Nuclear-cytoplasmic shuttling of the oncogenic mouse UNP/USP4 deubiquitylating enzyme.
The Journal of biological chemistry 2005;280(1):745-52.
2004: Catanzariti Ann-Maree; Soboleva Tatiana A; Jans David A; Board Philip G; Baker Rohan T
An efficient system for high-level expression and easy purification of authentic recombinant proteins.
Protein science : a publication of the Protein Society 2004;13(5):1331-9.
2004: Oro Cristina; Jans David A
The tumour specific pro-apoptotic factor apoptin (Vp3) from chicken anaemia virus.
Current drug targets 2004;5(2):179-90.
2003: Fulcher Alex J; Jans David A
The HIV-1 Tat transactivator protein: a therapeutic target?
IUBMB life 2003;55(12):669-80.
2003: Argentaro Anthony; Sim Helena; Kelly Sabine; Preiss Scott; Clayton Andrew; Jans David A; Harley Vincent R
A SOX9 defect of calmodulin-dependent nuclear import in campomelic dysplasia/autosomal sex reversal.
The Journal of biological chemistry 2003;278(36):33839-47.
2003: Harley Vincent R; Layfield Sharon; Mitchell Claire L; Forwood Jade K; John Anna P; Briggs Lyndall J; McDowall Sharon G; Jans David A
Defective importin beta recognition and nuclear import of the sex-determining factor SRY are associated with XY sex-reversing mutations.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(12):7045-50.
2003: Trapani Joseph A; Sutton Vivien R; Thia Kevin Y T; Li Yu Qin; Froelich Christopher J; Jans David A; Sandrin Mauro S; Browne Kylie A
A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death.
The Journal of cell biology 2003;160(2):223-33.
2003: Jans David A; Thomas Rachel J; Gillespie Matthew T
Parathyroid hormone-related protein (PTHrP): a nucleocytoplasmic shuttling protein with distinct paracrine and intracrine roles.
Vitamins and hormones 2003;66():345-84.
2002: Brooks Andrew J; Johansson Magnus; John Anna V; Xu Yibin; Jans David A; Vasudevan Subhash G
The interdomain region of dengue NS5 protein that binds to the viral helicase NS3 contains independently functional importin beta 1 and importin alpha/beta-recognized nuclear localization signals.
The Journal of biological chemistry 2002;277(39):36399-407.
2002: Forwood Jade K; Jans David A
Nuclear import pathway of the telomere elongation suppressor TRF1: inhibition by importin alpha.
Biochemistry 2002;41(30):9333-40.
2002: Chan Chee-Kai; Jans David A
Using nuclear targeting signals to enhance non-viral gene transfer.
Immunology and cell biology 2002;80(2):119-30.
2002: Lam Mark H C; Thomas Rachel J; Loveland Kate Lakoski; Schilders Steven; Gu Min; Martin T John; Gillespie Matthew T; Jans David A
Nuclear transport of parathyroid hormone (PTH)-related protein is dependent on microtubules.
Molecular endocrinology (Baltimore, Md.) 2002;16(2):390-401.
2002: Hübner Stefan; Jans David A; Xiao Chong-Yun; John Anna P; Drenckhahn Detlev
Signal- and importin-dependent nuclear targeting of the kidney anion exchanger 1-binding protein kanadaptin.
The Biochemical journal 2002;361(Pt 2):287-96.
2001: Johnson-Saliba M; Jans D A
Gene therapy: optimising DNA delivery to the nucleus.
Current drug targets 2001;2(4):371-99.
2001: Forwood J K; Harley V; Jans D A
The C-terminal nuclear localization signal of the sex-determining region Y (SRY) high mobility group domain mediates nuclear import through importin beta 1.
The Journal of biological chemistry 2001;276(49):46575-82.
2001: Lam M H; Henderson B; Gillespie M T; Jans D A
Dynamics of leptomycin B-sensitive nucleocytoplasmic flux of parathyroid hormone-related protein.
Traffic (Copenhagen, Denmark) 2001;2(11):812-9.
2001: Bird C H; Blink E J; Hirst C E; Buzza M S; Steele P M; Sun J; Jans D A; Bird P I
Nucleocytoplasmic distribution of the ovalbumin serpin PI-9 requires a nonconventional nuclear import pathway and the export factor Crm1.
Molecular and cellular biology 2001;21(16):5396-407.
2001: Preiss S; Argentaro A; Clayton A; John A; Jans D A; Ogata T; Nagai T; Barroso I; Schafer A J; Harley V R
Compound effects of point mutations causing campomelic dysplasia/autosomal sex reversal upon SOX9 structure, nuclear transport, DNA binding, and transcriptional activation.
The Journal of biological chemistry 2001;276(30):27864-72.
2001: Lixin R; Efthymiadis A; Henderson B; Jans D A
Novel properties of the nucleolar targeting signal of human angiogenin.
Biochemical and biophysical research communications 2001;284(1):185-93.
2001: Forwood J K; Lam M H; Jans D A
Nuclear import of Creb and AP-1 transcription factors requires importin-beta 1 and Ran but is independent of importin-alpha.
Biochemistry 2001;40(17):5208-17.
2001: Johansson M; Brooks A J; Jans D A; Vasudevan S G
A small region of the dengue virus-encoded RNA-dependent RNA polymerase, NS5, confers interaction with both the nuclear transport receptor importin-beta and the viral helicase, NS3.
The Journal of general virology 2001;82(Pt 4):735-45.
2001: Lam M H; Hu W; Xiao C Y; Gillespie M T; Jans D A
Molecular dissection of the importin beta1-recognized nuclear targeting signal of parathyroid hormone-related protein.
Biochemical and biophysical research communications 2001;282(2):629-34.
2001: Vasudevan S G; Johansson M; Brooks A J; Llewellyn L E; Jans D A
Characterisation of inter- and intra-molecular interactions of the dengue virus RNA dependent RNA polymerase as potential drug targets.
Farmaco (Società chimica italiana : 1989) 2001;56(1-2):33-6.
2001: Chan C K; Jans D A
Enhancement of MSH receptor- and GAL4-mediated gene transfer by switching the nuclear import pathway.
Gene therapy 2001;8(2):166-71.
2001: Briggs L J; Johnstone R W; Elliot R M; Xiao C Y; Dawson M; Trapani J A; Jans D A
Novel properties of the protein kinase CK2-site-regulated nuclear- localization sequence of the interferon-induced nuclear factor IFI 16.
The Biochemical journal 2001;353(Pt 1):69-77.
2001: Hübner S; Jans D A; Drenckhahn D
Roles of cytoskeletal and junctional plaque proteins in nuclear signaling.
International review of cytology 2001;208():207-65.
2000: Browne K A; Johnstone R W; Jans D A; Trapani J A
Filamin (280-kDa actin-binding protein) is a caspase substrate and is also cleaved directly by the cytotoxic T lymphocyte protease granzyme B during apoptosis.
The Journal of biological chemistry 2000;275(50):39262-6.
2000: Chan C K; Senden T; Jans D A
Supramolecular structure and nuclear targeting efficiency determine the enhancement of transfection by modified polylysines.
Gene therapy 2000;7(19):1690-7.
2000: Lam M H; Thomas R J; Martin T J; Gillespie M T; Jans D A
Nuclear and nucleolar localization of parathyroid hormone-related protein.
Immunology and cell biology 2000;78(4):395-402.
2000: Jans D A; Xiao C Y; Lam M H
Nuclear targeting signal recognition: a key control point in nuclear transport?
BioEssays : news and reviews in molecular, cellular and developmental biology 2000;22(6):532-44.
2000: Jans D A; Jans P; Jülich T; Briggs L J; Xiao C Y; Piller S C
Intranuclear binding by the HIV-1 regulatory protein VPR is dependent on cytosolic factors.
Biochemical and biophysical research communications 2000;270(3):1055-62.
2000: Johnson-Saliba M; Siddon N A; Clarkson M J; Tremethick D J; Jans D A
Distinct importin recognition properties of histones and chromatin assembly factors.
FEBS letters 2000;467(2-3):169-74.
1999: Browne K A; Blink E; Sutton V R; Froelich C J; Jans D A; Trapani J A
Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin.
Molecular and cellular biology 1999;19(12):8604-15.
1999: Chan C K; Jans D A
Synergy of importin alpha recognition and DNA binding by the yeast transcriptional activator GAL4.
FEBS letters 1999;462(1-2):221-4.
1999: Hübner S; Smith H M; Hu W; Chan C K; Rihs H P; Paschal B M; Raikhel N V; Jans D A
Plant importin alpha binds nuclear localization sequences with high affinity and can mediate nuclear import independent of importin beta.
The Journal of biological chemistry 1999;274(32):22610-7.
1999: Chan C K; Jans D A
Enhancement of polylysine-mediated transferrinfection by nuclear localization sequences: polylysine does not function as a nuclear localization sequence.
Human gene therapy 1999;10(10):1695-702.
1999: Blink E J; Trapani J A; Jans D A
Perforin-dependent nuclear targeting of granzymes: A central role in the nuclear events of granule-exocytosis-mediated apoptosis?
Immunology and cell biology 1999;77(3):206-15.
1999: Hu W; Jans D A
Efficiency of importin alpha/beta-mediated nuclear localization sequence recognition and nuclear import. Differential role of NTF2.
The Journal of biological chemistry 1999;274(22):15820-7.
1999: Piller S C; Ewart G D; Jans D A; Gage P W; Cox G B
The amino-terminal region of Vpr from human immunodeficiency virus type 1 forms ion channels and kills neurons.
Journal of virology 1999;73(5):4230-8.
1999: Forwood J K; Brooks A; Briggs L J; Xiao C Y; Jans D A; Vasudevan S G
The 37-amino-acid interdomain of dengue virus NS5 protein contains a functional NLS and inhibitory CK2 site.
Biochemical and biophysical research communications 1999;257(3):731-7.
1999: Lam M H; Briggs L J; Hu W; Martin T J; Gillespie M T; Jans D A
Importin beta recognizes parathyroid hormone-related protein with high affinity and mediates its nuclear import in the absence of importin alpha.
The Journal of biological chemistry 1999;274(11):7391-8.
1999: Jans D A; Sutton V R; Jans P; Froelich C J; Trapani J A
BCL-2 blocks perforin-induced nuclear translocation of granzymes concomitant with protection against the nuclear events of apoptosis.
The Journal of biological chemistry 1999;274(7):3953-61.
1998: Xiao C Y; Jans P; Jans D A
Negative charge at the protein kinase CK2 site enhances recognition of the SV40 large T-antigen NLS by importin: effect of conformation.
FEBS letters 1998;440(3):297-301.
1998: Xiao C Y; Jans D A
An engineered site for protein kinase C flanking the SV40 large T-antigen NLS confers phorbol ester-inducible nuclear import.
FEBS letters 1998;436(3):313-7.
1998: Trapani J A; Jans D A; Jans P J; Smyth M J; Browne K A; Sutton V R
Efficient nuclear targeting of granzyme B and the nuclear consequences of apoptosis induced by granzyme B and perforin are caspase-dependent, but cell death is caspase-independent.
The Journal of biological chemistry 1998;273(43):27934-8.
1998: Chan C K; Hübner S; Hu W; Jans D A
Mutual exclusivity of DNA binding and nuclear localization signal recognition by the yeast transcription factor GAL4: implications for nonviral DNA delivery.
Gene therapy 1998;5(9):1204-12.
1998: Jans D A; Briggs L J; Jans P; Froelich C J; Parasivam G; Kumar S; Sutton V R; Trapani J A
Nuclear targeting of the serine protease granzyme A (fragmentin-1).
Journal of cell science 1998;111 ( Pt 17)():2645-54.
1998: Briggs L J; Stein D; Goltz J; Corrigan V C; Efthymiadis A; Hübner S; Jans D A
The cAMP-dependent protein kinase site (Ser312) enhances dorsal nuclear import through facilitating nuclear localization sequence/importin interaction.
The Journal of biological chemistry 1998;273(35):22745-52.
1998: Efthymiadis A; Dottorini T; Jans D A
A novel system to quantitate nuclear-cytoplasmic flux in vivo: kinetics of signal-dependent nuclear protein export.
Archives of biochemistry and biophysics 1998;355(2):254-61.
1998: Jans D A; Chan C K; Huebner S
Signals mediating nuclear targeting and their regulation: application in drug delivery.
Medicinal research reviews 1998;18(4):189-223.
1998: Trapani J A; Jans P; Smyth M J; Froelich C J; Williams E A; Sutton V R; Jans D A
Perforin-dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunction.
Cell death and differentiation 1998;5(6):488-96.
1998: Jans D A; Hassan G
Nuclear targeting by growth factors, cytokines, and their receptors: a role in signaling?
BioEssays : news and reviews in molecular, cellular and developmental biology 1998;20(5):400-11.
1998: Piller S C; Jans P; Gage P W; Jans D A
Extracellular HIV-1 virus protein R causes a large inward current and cell death in cultured hippocampal neurons: implications for AIDS pathology.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(8):4595-600.
1998: Efthymiadis A; Briggs L J; Jans D A
The HIV-1 Tat nuclear localization sequence confers novel nuclear import properties.
The Journal of biological chemistry 1998;273(3):1623-8.
1998: Trapani J A; Jans D A; Sutton V R
Lymphocyte granule-mediated cell death.
Springer seminars in immunopathology 1998;19(3):323-43.
1997: Xiao C Y; Hübner S; Jans D A
SV40 large tumor antigen nuclear import is regulated by the double-stranded DNA-dependent protein kinase site (serine 120) flanking the nuclear localization sequence.
The Journal of biological chemistry 1997;272(35):22191-8.
1997: Efthymiadis A; Shao H; Hübner S; Jans D A
Kinetic characterization of the human retinoblastoma protein bipartite nuclear localization sequence (NLS) in vivo and in vitro. A comparison with the SV40 large T-antigen NLS.
The Journal of biological chemistry 1997;272(35):22134-9.
1997: Hübner S; Xiao C Y; Jans D A
The protein kinase CK2 site (Ser111/112) enhances recognition of the simian virus 40 large T-antigen nuclear localization sequence by importin.
The Journal of biological chemistry 1997;272(27):17191-5.
1997: Jans D A; Briggs L J; Gustin S E; Jans P; Ford S; Young I G
The cytokine interleukin-5 (IL-5) effects cotransport of its receptor subunits to the nucleus in vitro.
FEBS letters 1997;410(2-3):368-72.
1997: Jans D A; Briggs L J; Gustin S E; Jans P; Ford S; Young I G
A functional bipartite nuclear localisation signal in the cytokine interleukin-5.
FEBS letters 1997;406(3):315-20.

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