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Jacob Jansen

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Piya Temviriyanukul; Sandrine van Hees-Stuivenberg; Niels De Wind; Frédéric Delbos; Heinz Jacobs; Jacob G Jansen
Temporally distinct translesion synthesis pathways for ultraviolet light-induced photoproducts in the mammalian genome.
Piya Temviriyanukul; Sandrine van Hees-Stuivenberg; Matty Meijers; Haruo Ohmori; J J W A Boei; Niels De Wind; Frédéric Delbos; Jacob G Jansen
Different sets of translesion synthesis DNA polymerases protect from genome instability induced by distinct food-derived genotoxins.
Peter Krijger; Petra Langerak; Claude-Agnès Reynaud; Paul van den Berk; Niek Wit; Niels De Wind; Jacob G Jansen; Heinz Jacobs
PCNA ubiquitination-independent activation of polymerase η during somatic hypermutation and DNA damage tolerance.

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All Publications

2012: Piya Temviriyanukul; Sandrine van Hees-Stuivenberg; Niels De Wind; Frédéric Delbos; Heinz Jacobs; Jacob G Jansen
Temporally distinct translesion synthesis pathways for ultraviolet light-induced photoproducts in the mammalian genome.
DNA repair 2012;11(6):550-8.
2012: Piya Temviriyanukul; Sandrine van Hees-Stuivenberg; Matty Meijers; Haruo Ohmori; J J W A Boei; Niels De Wind; Frédéric Delbos; Jacob G Jansen
Different sets of translesion synthesis DNA polymerases protect from genome instability induced by distinct food-derived genotoxins.
Toxicological sciences : an official journal of the Society of Toxicology 2012;127(1):130-8.
2011: Peter Krijger; Petra Langerak; Claude-Agnès Reynaud; Paul van den Berk; Niek Wit; Niels De Wind; Jacob G Jansen; Heinz Jacobs
PCNA ubiquitination-independent activation of polymerase η during somatic hypermutation and DNA damage tolerance.
DNA repair 2011;10(10):1051-9.
2011: Frederik H de Groote; Niels De Wind; Jacob G Jansen; Kenji Kamiya; Yuji Masuda; Dipen M Shah; Gregg Siegal
The Rev1 translesion synthesis polymerase has multiple distinct DNA binding modes.
DNA repair 2011;10(9):915-25.
2010: Giel Hendriks; Jacob G Jansen; Leon H F Mullenders; Niels De Wind
Transcription-coupled repair and apoptosis provide specific protection against transcription-associated mutagenesis by ultraviolet light.
Transcription 2010;1(2):95-8.
2010: Giel Hendriks; Jacob G Jansen; Leon H F Mullenders; Niels De Wind
Transcription and replication: far relatives make uneasy bedfellows.
Cell cycle (Georgetown, Tex.) 2010;9(12):2300-4.
2010: Giel Hendriks; Fabienne Calléja; Ahmad Besaratinia; Harry Vrieling; Gerd P Pfeifer; Leon H F Mullenders; Jacob G Jansen; Niels De Wind
Transcription-dependent cytosine deamination is a novel mechanism in ultraviolet light-induced mutagenesis.
Current biology : CB 2010;20(2):170-5.
2009: Anastasia Tsaalbi-Shtylik; Johan W A Verspuy; Jacob G Jansen; Heggert Rebel; Leone M Carlée; Martin A van der Valk; Jos Jonkers; Frank R de Gruijl; Niels De Wind
Error-prone translesion replication of damaged DNA suppresses skin carcinogenesis by controlling inflammatory hyperplasia.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(51):21836-41.
2009: Jacob G Jansen; Anastasia Tsaalbi-Shtylik; Giel Hendriks; Johan Verspuy; Himabindu Gali; Lajos Haracska; Niels De Wind
Mammalian polymerase zeta is essential for post-replication repair of UV-induced DNA lesions.
DNA repair 2009;8(12):1444-51.
2009: Jacob G Jansen; Anastasia Tsaalbi-Shtylik; Niels De Wind
Functional interactions between DNA damage signaling and mutagenic translesion synthesis at post-replicative gaps.
Cell cycle (Georgetown, Tex.) 2009;8(18):2857-8.
2009: Jacob G Jansen; Anastasia Tsaalbi-Shtylik; Giel Hendriks; Himabindu Gali; Ayal Hendel; Fredrik Johansson; Klaus Erixon; Zvi Livneh; Leon H F Mullenders; Lajos Haracska; Niels De Wind
Separate domains of Rev1 mediate two modes of DNA damage bypass in mammalian cells.
Molecular and cellular biology 2009;29(11):3113-23.
2009: Alex Pines; Claude Backendorf; Sergey Alekseev; Jacob G Jansen; Frank R de Gruijl; Harry Vrieling; Leon H F Mullenders
Differential activity of UV-DDB in mouse keratinocytes and fibroblasts: impact on DNA repair and UV-induced skin cancer.
DNA repair 2009;8(2):153-61.
2008: Giel Hendriks; Fabienne Calléja; Harry Vrieling; Leon H F Mullenders; Jacob G Jansen; Niels De Wind
Gene transcription increases DNA damage-induced mutagenesis in mammalian stem cells.
DNA repair 2008;7(8):1330-9.
2008: Albert A van Zeeland; Anton J de Groot; Georges R Mohn; Harry van Steeg; Conny Th M van Oostrom; Anne-Marie van Duijn-Goedhart; Leon F H Mullenders; Jacob G Jansen
Reduced methylation-induced mutagenesis in rat splenocytes in vivo by sub-chronic low dose exposure to N-metyl-N-nitrosourea.
Mutation research 2008;640(1-2):131-8.
2007: Jacob G Jansen; Maria Fousteri; Niels De Wind
Send in the clamps: control of DNA translesion synthesis in eukaryotes.
Molecular cell 2007;28(4):522-9.
2006: Jacob G Jansen; Petra Langerak; Anastasia Tsaalbi-Shtylik; Paul van den Berk; Heinz Jacobs; Niels De Wind
Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice.
The Journal of experimental medicine 2006;203(2):319-23.
2005: Jacob G Jansen; Anastasia Tsaalbi-Shtylik; Petra Langerak; Fabienne Calléja; Carel Meijers; Heinz Jacobs; Niels De Wind
The BRCT domain of mammalian Rev1 is involved in regulating DNA translesion synthesis.
Nucleic acids research 2005;33(1):356-65.
2003: Jacob G Jansen; Niels De Wind
Biological functions of translesion synthesis proteins in vertebrates.
DNA repair 2003;2(10):1075-85.
1999: Petra P H Van Sloun; Jacob G Jansen; G Weeda; Leon H F Mullenders; Albert A van Zeeland; Paul H M Lohman; Harry Vrieling
The role of nucleotide excision repair in protecting embryonic stem cells from genotoxic effects of UV-induced DNA damage.
Nucleic acids research 1999;27(16):3276-82.
1999: SA Bol; Harry van Steeg; Conny Th M van Oostrom; Ad D Tates; Harry Vrieling; Anton J de Groot; Leon H F Mullenders; Albert A van Zeeland; Jacob G Jansen
Nucleotide excision repair modulates the cytotoxic and mutagenic effects of N-n-butyl-N-nitrosourea in cultured mammalian cells as well as in mouse splenocytes in vivo.
Mutagenesis 1999;14(3):317-22.
1999: Fabienne Calléja; Jacob G Jansen; Harry Vrieling; F Laval; Albert A van Zeeland
Modulation of the toxic and mutagenic effects induced by methyl methanesulfonate in Chinese hamster ovary cells by overexpression of the rat N-alkylpurine-DNA glycosylase.
Mutation research 1999;425(2):185-94.
1998: R H Elder; Jacob G Jansen; Robert Weeks; MA Willington; B Deans; Amanda J Watson; K J Mynett; J A Bailey; Donald P Cooper; Joseph Rafferty; M C Heeran; Susan W P Wijnhoven; Albert A van Zeeland; Geoffrey P Margison
Alkylpurine-DNA-N-glycosylase knockout mice show increased susceptibility to induction of mutations by methyl methanesulfonate.
Molecular and cellular biology 1998;18(10):5828-37.
1998: SA Bol; Harry van Steeg; Jacob G Jansen; Conny Th M van Oostrom; Annemieke de Vries; Anton J de Groot; Ad D Tates; Harry Vrieling; Albert A van Zeeland; Leon H F Mullenders
Elevated frequencies of benzo(a)pyrene-induced Hprt mutations in internal tissue of XPA-deficient mice.
Cancer research 1998;58(13):2850-6.
1997: C W Op het Veld; Sandrine van Hees-Stuivenberg; Albert A van Zeeland; Jacob G Jansen
Effect of nucleotide excision repair on hprt gene mutations in rodent cells exposed to DNA ethylating agents.
Mutagenesis 1997;12(6):417-24.
1996: Jacob G Jansen; Anton J de Groot; C M van Teijlingen; Ad D Tates; Harry Vrieling; Albert A van Zeeland
Induction of hprt gene mutations in splenic T-lymphocytes from the rat exposed in vivo to DNA methylating agents is correlated with formation of O6-methylguanine in bone marrow and not in the spleen.
Carcinogenesis 1996;17(10):2183-91.
1995: Albert A van Zeeland; Jacob G Jansen; G R Mohn; Harry Vrieling; Ad D Tates; Paul H M Lohman
Detection of point mutations in T lymphocytes.
Clinical chemistry 1995;41(12 Pt 2):1841-3.
1995: Jacob G Jansen; Harry Vrieling; C M van Teijlingen; G R Mohn; Ad D Tates; Albert A van Zeeland
Marked differences in the role of O6-alkylguanine in hprt mutagenesis in T-lymphocytes of rats exposed in vivo to ethylmethanesulfonate, N-(2-hydroxyethyl)-N-nitrosourea, or N-ethyl-N-nitrosourea.
Cancer research 1995;55(9):1875-82.
1995: Albert A van Zeeland; Jacob G Jansen; A de Groot; S van Hees; C M van Teijlingen; C W op het Veld; Malgorzata Z Zdzienicka; Paul H M Lohman; Harry Vrieling
Mechanisms and biomarkers of genotoxicity. Molecular dosimetry of chemical mutagens.
Toxicology letters 1995;77(1-3):49-54.
1994: Jacob G Jansen; C M van Teijlingen; G R Mohn; Albert A van Zeeland; Harry Vrieling
AT base pairs are the main target for mutations at the hprt locus of rat skin fibroblasts exposed in vitro to the monofunctional alkylating agent N-ethyl-N-nitrosourea.
Mutagenesis 1994;9(5):417-21.
1994: Jacob G Jansen; G R Mohn; Harry Vrieling; C M van Teijlingen; Paul H M Lohman; Albert A van Zeeland
Molecular analysis of hprt gene mutations in skin fibroblasts of rats exposed in vivo to N-methyl-N-nitrosourea or N-ethyl-N-nitrosourea.
Cancer research 1994;54(9):2478-85.
1994: Jacob G Jansen; Anton J de Groot; C M van Teijlingen; Paul H M Lohman; G R Mohn; Harry Vrieling; Albert A van Zeeland
Formation and persistence of DNA adducts in pouch skin fibroblasts and liver tissue of rats exposed in vivo to the monofunctional alkylating agents N-methyl-N-nitrosourea or N-ethyl-N-nitrosourea.
Mutation research 1994;307(1):95-105.
1994: Anton J de Groot; Jacob G Jansen; C F van Valkenburg; Albert A van Zeeland
Molecular dosimetry of 7-alkyl- and O6-alkylguanine in DNA by electrochemical detection.
Mutation research 1994;307(1):61-6.
1992: Jacob G Jansen; Harry Vrieling; Albert A van Zeeland; G R Mohn
The gene encoding hypoxanthine-guanine phosphoribosyltransferase as target for mutational analysis: PCR cloning and sequencing of the cDNA from the rat.
Mutation research 1992;266(2):105-16.