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Joop Janssen

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Aimee J Varewijck; Wilmar M Wiersinga; Steven W J Lamberts; Anita Boelen; Eric Fliers; Leo Hofland; Joop A M J L Janssen
Circulating IgGs may modulate IGF-I receptor stimulating activity in a subset of patients with Graves' ophthalmopathy.
Aimee J Varewijck; Leo Hofland; Steven W J Lamberts; Sebastian J C M M Neggers; Joop A M J L Janssen
IGF-I bioactivity might reflect different aspects of quality of life than total IGF-I in GH-deficient patients during GH treatment.
Annewieke W van den Beld; Werner F Blum; Michael P Brugts; Diederick E Grobbee; Joop A M J L Janssen; Steven W J Lamberts
High IGFBP2 levels are not only associated with a better metabolic risk profile but also with increased mortality in elderly men.

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2013: Aimee J Varewijck; Wilmar M Wiersinga; Steven W J Lamberts; Anita Boelen; Eric Fliers; Leo Hofland; Joop A M J L Janssen
Circulating IgGs may modulate IGF-I receptor stimulating activity in a subset of patients with Graves' ophthalmopathy.
The Journal of clinical endocrinology and metabolism 2013;98(2):769-76.
2013: Aimee J Varewijck; Leo Hofland; Steven W J Lamberts; Sebastian J C M M Neggers; Joop A M J L Janssen
IGF-I bioactivity might reflect different aspects of quality of life than total IGF-I in GH-deficient patients during GH treatment.
The Journal of clinical endocrinology and metabolism 2013;98(2):761-8.
2012: Annewieke W van den Beld; Werner F Blum; Michael P Brugts; Diederick E Grobbee; Joop A M J L Janssen; Steven W J Lamberts
High IGFBP2 levels are not only associated with a better metabolic risk profile but also with increased mortality in elderly men.
European journal of endocrinology / European Federation of Endocrine Societies 2012;167(1):111-7.
2011: Marijke Gielen; Joop A M J L Janssen; Steven Lamberts; Dieter Mesotten; Robert Baxter; Michael Brugts; Willy Coopmans; Erik Van Herck; Ilse Vanhorebeek; Greet Van den Berghe
Effect of intensive insulin therapy on the somatotropic axis of critically ill children.
The Journal of clinical endocrinology and metabolism 2011;96(8):2558-66.
2010: Michael P Brugts; Cornelia M van Duijn; Leo J Hofland; Jacqueline C Witteman; Steven W J Lamberts; Joop A M J L Janssen
Igf-I bioactivity in an elderly population: relation to insulin sensitivity, insulin levels, and the metabolic syndrome.
Diabetes 2010;59(2):505-8.
2009: M P Brugts; J G L M Luermans; E G W M Lentjes; N J van Trooyen-van Vrouwerff; F A L van der Horst; Peter Slee; S W J Lamberts; Joop A M J L Janssen
Heterophilic antibodies may be a cause of falsely low total IGF1 levels.
European journal of endocrinology / European Federation of Endocrine Societies 2009;161(4):561-5.
2009: Joop A M J L Janssen
Advantages and disadvantages of GH/IGF-I combination treatment.
Reviews in endocrine & metabolic disorders 2009;10(2):157-62.
2009: Giovanni Vitale; Peter M Van Koetsveld; Wouter W de Herder; Katy van der Wansem; Joop A M J L Janssen; Annamaria Colao; Gaetano Lombardi; Steven W J Lamberts; Leo J Hofland
Effects of type I interferons on IGF-mediated autocrine/paracrine growth of human neuroendocrine tumor cells.
American journal of physiology. Endocrinology and metabolism 2009;296(3):E559-66.
2008: S J C M M Neggers; Maarten O van Aken; Wouter W de Herder; Richard A Feelders; Joop A M J L Janssen; X Badia; S M Webb; Aart Jan Van der Lely
Quality of life in acromegalic patients during long-term somatostatin analog treatment with and without pegvisomant.
The Journal of clinical endocrinology and metabolism 2008;93(10):3853-9.
2008: M P Brugts; Annewieke W van den Beld; Leo J Hofland; K van der Wansem; Peter M Van Koetsveld; Jan Frystyk; S W J Lamberts; Joop A M J L Janssen
Low circulating insulin-like growth factor I bioactivity in elderly men is associated with increased mortality.
The Journal of clinical endocrinology and metabolism 2008;93(7):2515-22.
2008: Michael P Brugts; Michael B Ranke; Leo J Hofland; Katy van der Wansem; Karin Weber; Jan Frystyk; Steven W J Lamberts; Joop A M J L Janssen
Normal values of circulating insulin-like growth factor-I bioactivity in the healthy population: comparison with five widely used IGF-I immunoassays.
The Journal of clinical endocrinology and metabolism 2008;93(7):2539-45.
2007: Sebastian J C M M Neggers; Maarten O van Aken; Joop A M J L Janssen; Richard A Feelders; Wouter W de Herder; Aart Jan Van der Lely
Long-term efficacy and safety of combined treatment of somatostatin analogs and pegvisomant in acromegaly.
The Journal of clinical endocrinology and metabolism 2007;92(12):4598-601.
2007: Carlotta Gauna; Piet Uitterlinden; Piet Kramer; Rosalie M Kiewiet; Joop A M J L Janssen; Patric J D Delhanty; Maarten O van Aken; Ezio Ghigo; Leo J Hofland; Axel P N Themmen; Aart Jan Van der Lely
Intravenous glucose administration in fasting rats has differential effects on acylated and unacylated ghrelin in the portal and systemic circulation: a comparison between portal and peripheral concentrations in anesthetized rats.
Endocrinology 2007;148(11):5278-87.
2007: Carlotta Gauna; Rosalie M Kiewiet; Joop A M J L Janssen; Bedette van de Zande; Patric J D Delhanty; Ezio Ghigo; Leo J Hofland; Axel P N Themmen; Aart Jan Van der Lely
Unacylated ghrelin acts as a potent insulin secretagogue in glucose-stimulated conditions.
American journal of physiology. Endocrinology and metabolism 2007;293(3):E697-704.
2007: Angela M González-Zuloeta Ladd; Fan Liu; M P W A Houben; Alejandro Arias-Vásquez; Claire Siemes; A Cecile J W Janssens; J W W Coebergh; Albert Hofman; Joop A M J L Janssen; Bruno H Ch Stricker; C.M. Duijn
IGF-1 CA repeat variant and breast cancer risk in postmenopausal women.
European journal of cancer (Oxford, England : 1990) 2007;43(11):1718-22.
2007: Mojgan Yazdanpanah; Yurii Aulchenko; Albert Hofman; Joop A M J L Janssen; Fakhredin A Sayed-Tabatabaei; Ron van Schaik; Olaf Klungel; Bruno H Ch Stricker; Huibert A P Pols; Jacqueline C M Witteman; Steven W J Lamberts; Ben A Oostra; C.M. Duijn
Effects of the renin-angiotensin system genes and salt sensitivity genes on blood pressure and atherosclerosis in the total population and patients with type 2 diabetes.
Diabetes 2007;56(7):1905-12.
2007: Robin P Peeters; Wendy M van der Deure; Annewieke W van den Beld; Hans van Toor; Steven W J Lamberts; Joop A M J L Janssen; André G Uitterlinden; Theo J Visser
The Asp727Glu polymorphism in the TSH receptor is associated with insulin resistance in healthy elderly men.
Clinical endocrinology 2007;66(6):808-15.
2007: Peter Hovind; Steven Lamberts; Wim Hop; jaap deinum; Lise Tarnow; Hans-Henrik Parving; Joop A M J L Janssen
An IGF-I gene polymorphism modifies the risk of developing persistent microalbuminuria in type 1 diabetes.
European journal of endocrinology / European Federation of Endocrine Societies 2007;156(1):83-90.
2006: Mojgan Yazdanpanah; Fakhredin A Sayed-Tabatabaei; Joop A M J L Janssen; Ingrid Rietveld; Albert Hofman; Theo Stijnen; Huibert A P Pols; Steven W J Lamberts; Jacqueline C M Witteman; C.M. Duijn
IGF-I gene promoter polymorphism is a predictor of survival after myocardial infarction in patients with type 2 diabetes.
European journal of endocrinology / European Federation of Endocrine Societies 2006;155(5):751-6.
2006: Mojgan Yazdanpanah; Fakhredin A Sayed-Tabatabaei; Albert Hofman; Yurii Aulchenko; Ben A Oostra; Bruno H Ch Stricker; Huibert A P Pols; Steven W J Lamberts; Jacqueline C M Witteman; Joop A M J L Janssen; C.M. Duijn
The alpha-adducin gene is associated with macrovascular complications and mortality in patients with type 2 diabetes.
Diabetes 2006;55(10):2922-7.
2006: Ingrid Rietveld; M Kamran Ikram; Johannes Vingerling; Albert Hofman; Huibert A P Pols; Steven W J Lamberts; Paulus T V M de Jong; C.M. Duijn; Joop A M J L Janssen
An igf-I gene polymorphism modifies the risk of diabetic retinopathy.
Diabetes 2006;55(8):2387-91.
2006: Adrienne A M Zandbergen; Steven W J Lamberts; Joop A M J L Janssen; Aart H Bootsma
Short-term administration of an angiotensin-receptor antagonist in patients with impaired fasting glucose improves insulin sensitivity and increases free IGF-I.
European journal of endocrinology / European Federation of Endocrine Societies 2006;155(2):293-6.
2006: Carlotta Gauna; Patric J D Delhanty; Maarten O van Aken; Joop A M J L Janssen; Axel P N Themmen; Leo J Hofland; Michael Culler; Fabio Broglio; Ezio Ghigo; Aart Jan Van der Lely
Unacylated ghrelin is active on the INS-1E rat insulinoma cell line independently of the growth hormone secretagogue receptor type 1a and the corticotropin releasing factor 2 receptor.
Molecular and cellular endocrinology 2006;251(1-2):103-11.
2006: Ingrid Rietveld; Albert Hofman; Huibert A P Pols; C.M. Duijn; Steven W J Lamberts; Joop A M J L Janssen
An insulin-like growth factor-I gene polymorphism modifies the risk of microalbuminuria in subjects with an abnormal glucose tolerance.
European journal of endocrinology / European Federation of Endocrine Societies 2006;154(5):715-21.
2006: Mojgan Yazdanpanah; Ingrid Rietveld; Joop A M J L Janssen; Omer T Njajou; Albert Hofman; Theo Stijnen; Huibert A P Pols; Steven W J Lamberts; Jacqueline C M Witteman; C.M. Duijn
An insulin-like growth factor-I promoter polymorphism is associated with increased mortality in subjects with myocardial infarction in an elderly Caucasian population.
The American journal of cardiology 2006;97(9):1274-6.
2006: M Kamran Ikram; Joop A M J L Janssen; Anna M E Roos; Ingrid Rietveld; Jacqueline C M Witteman; Monique Breteler; Albert Hofman; C.M. Duijn; Paulus T V M de Jong
Retinal vessel diameters and risk of impaired fasting glucose or diabetes: the Rotterdam study.
Diabetes 2006;55(2):506-10.
2006: Adrienne A M Zandbergen; Steven W J Lamberts; Marinus G A Baggen; Joop A M J L Janssen; eric boersma; Aart H Bootsma
The IGF-I system and the renal and haemodynamic effects of losartan in normotensive patients with type 2 diabetes mellitus: a randomized clinical trial.
Clinical endocrinology 2006;64(2):203-8.
2005: Richard A Feelders; Martin Bidlingmaier; Christian J Strasburger; Joop A M J L Janssen; Piet Uitterlinden; Leo J Hofland; Steven W J Lamberts; Aart Jan Van der Lely; Wouter W de Herder
Postoperative evaluation of patients with acromegaly: clinical significance and timing of oral glucose tolerance testing and measurement of (free) insulin-like growth factor I, acid-labile subunit, and growth hormone-binding protein levels.
The Journal of clinical endocrinology and metabolism 2005;90(12):6480-9.
2005: Wouter W de Herder; H Rob Taal; Piet Uitterlinden; Richard A Feelders; Joop A M J L Janssen; Aart Jan Van der Lely
Limited predictive value of an acute test with subcutaneous octreotide for long-term IGF-I normalization with Sandostatin LAR in acromegaly.
European journal of endocrinology / European Federation of Endocrine Societies 2005;153(1):67-71.
2005: Robin P Peeters; Annewieke W van den Beld; Hayat Attalki; Hans van Toor; Yolanda B De Rijke; George G J M Kuiper; Steven W J Lamberts; Joop A M J L Janssen; André G Uitterlinden; Theo J Visser
A new polymorphism in the type II deiodinase gene is associated with circulating thyroid hormone parameters.
American journal of physiology. Endocrinology and metabolism 2005;289(1):E75-81.
2005: Johannes Feenstra; Wouter W de Herder; Saskia M T H ten Have; Annewieke W van den Beld; Richard A Feelders; Joop A M J L Janssen; Aart Jan Van der Lely
Combined therapy with somatostatin analogues and weekly pegvisomant in active acromegaly.
Lancet 2005;365(9471):1644-6.
2005: Ingrid E Bonapart; Ron T van Domburg; Saskia M T H ten Have; Wouter W de Herder; Ruud A M Erdman; Joop A M J L Janssen; Aart Jan Van der Lely
The 'bio-assay' quality of life might be a better marker of disease activity in acromegalic patients than serum total IGF-I concentrations.
European journal of endocrinology / European Federation of Endocrine Societies 2005;152(2):217-24.
2005: Gysèle S Bleumink; A F C Schut; Miriam C J M Sturkenboom; Joop A M J L Janssen; Jacqueline C M Witteman; C.M. Duijn; Albert Hofman; Bruno H Ch Stricker
A promoter polymorphism of the insulin-like growth factor-I gene is associated with left ventricular hypertrophy.
Heart (British Cardiac Society) 2005;91(2):239-40.
2005: Carlotta Gauna; Patric J D Delhanty; Leo J Hofland; Joop A M J L Janssen; Fabio Broglio; Richard J M Ross; Ezio Ghigo; Aart Jan Van der Lely
Ghrelin stimulates, whereas des-octanoyl ghrelin inhibits, glucose output by primary hepatocytes.
The Journal of clinical endocrinology and metabolism 2005;90(2):1055-60.
2005: Robin P Peeters; Annewieke W van den Beld; Hans van Toor; André G Uitterlinden; Joop A M J L Janssen; Steven W J Lamberts; Theo J Visser
A polymorphism in type I deiodinase is associated with circulating free insulin-like growth factor I levels and body composition in humans.
The Journal of clinical endocrinology and metabolism 2005;90(1):256-63.
2004: Carlotta Gauna; F M Meyler; Joop A M J L Janssen; Patric J D Delhanty; T Abribat; Peter M Van Koetsveld; Leo J Hofland; Fabio Broglio; Ezio Ghigo; Aart Jan Van der Lely
Administration of acylated ghrelin reduces insulin sensitivity, whereas the combination of acylated plus unacylated ghrelin strongly improves insulin sensitivity.
The Journal of clinical endocrinology and metabolism 2004;89(10):5035-42.
2004: Joop A M J L Janssen; Mark F Wildhagen; K Ito; Bert G Blijenberg; Ron van Schaik; Monique J Roobol; Huibert A P Pols; Steven W J Lamberts; F H Schröder
Circulating free insulin-like growth factor (IGF)-I, total IGF-I, and IGF binding protein-3 levels do not predict the future risk to develop prostate cancer: results of a case-control study involving 201 patients within a population-based screening with a 4-year interval.
The Journal of clinical endocrinology and metabolism 2004;89(9):4391-6.
2004: Elisabeth F C van Rossum; Richard A Feelders; Annewieke W van den Beld; André G Uitterlinden; Joop A M J L Janssen; Wietske Ester; Albert O Brinkmann; Diederick Grobbee; Frank de Jong; Huibert A P Pols; Jan W Koper; Steven W J Lamberts
Association of the ER22/23EK polymorphism in the glucocorticoid receptor gene with survival and C-reactive protein levels in elderly men.
The American journal of medicine 2004;117(3):158-62.
2004: Gysèle S Bleumink; Ingrid Rietveld; Joop A M J L Janssen; Elisabeth F C van Rossum; Jaap Deckers; Albert Hofman; Jacqueline C M Witteman; C.M. Duijn; Bruno H Ch Stricker
Insulin-like growth factor-I gene polymorphism and risk of heart failure (the Rotterdam Study).
The American journal of cardiology 2004;94(3):384-6.
2004: Ingrid Rietveld; Joop A M J L Janssen; Elisabeth F C van Rossum; Jeanine J Houwing-Duistermaat; Fernando Rivadeneira; Albert Hofman; Huibert A P Pols; C.M. Duijn; Steven W J Lamberts
A polymorphic CA repeat in the IGF-I gene is associated with gender-specific differences in body height, but has no effect on the secular trend in body height.
Clinical endocrinology 2004;61(2):195-203.
2004: Fernando Rivadeneira; Jeanine J Houwing-Duistermaat; Thomas J Beck; Joop A M J L Janssen; Albert Hofman; Huibert A P Pols; C.M. Duijn; André G Uitterlinden
The influence of an insulin-like growth factor I gene promoter polymorphism on hip bone geometry and the risk of nonvertebral fracture in the elderly: the Rotterdam Study.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004;19(8):1280-90.
2004: Joop A M J L Janssen; Willy Visser; Aart Jan Van der Lely
[Still no indications that the treatment of growth hormone deficient adults with growth hormones is unsafe].
Nederlands tijdschrift voor geneeskunde 2004;148(30):1486-9.
2004: Joop A M J L Janssen; D Poldermans; Leo J Hofland; Eleni C Vourvouri; Alex F Muller; J J Bax; R Deghenghi; Fabio Broglio; Ezio Ghigo; Aart Jan Van der Lely
There are no acute cardiac effects of a single iv dose of human ghrelin in severe growth hormone deficient patients.
Journal of endocrinological investigation 2004;27(7):659-64.
2004: Joop A M J L Janssen; Aart Jan Van der Lely; Steven W J Lamberts
Is there a role of ghrelin in preventing catabolism?
Journal of endocrinological investigation 2004;27(4):400-3.
2004: Joop A M J L Janssen; Steven W J Lamberts
Igf-I and longevity.
Hormone research 2004;62 Suppl 3():104-9.
2003: Elisabeth F C van Rossum; Jan W Koper; Annewieke W van den Beld; André G Uitterlinden; Pascal P Arp; Wietske Ester; Joop A M J L Janssen; Albert O Brinkmann; Frank de Jong; Diederick Grobbee; Huibert A P Pols; Steven W J Lamberts
Identification of the BclI polymorphism in the glucocorticoid receptor gene: association with sensitivity to glucocorticoids in vivo and body mass index.
Clinical endocrinology 2003;59(5):585-92.
2003: A F C Schut; Joop A M J L Janssen; jaap deinum; Jeannette M Vergeer; Albert Hofman; Steven W J Lamberts; Ben A Oostra; Huibert A P Pols; Jacqueline C M Witteman; C.M. Duijn
Polymorphism in the promoter region of the insulin-like growth factor I gene is related to carotid intima-media thickness and aortic pulse wave velocity in subjects with hypertension.
Stroke; a journal of cerebral circulation 2003;34(7):1623-7.
2003: Joop A M J L Janssen; Aart Jan Van der Lely; Steven W J Lamberts
Circulating free insulin-like growth-factor-I (IGF-I) levels should also be measured to estimate the IGF-I bioactivity.
Journal of endocrinological investigation 2003;26(6):588-94.
2003: Ingrid Rietveld; Joop A M J L Janssen; Albert Hofman; Huibert A P Pols; C.M. Duijn; Steven W J Lamberts
A polymorphism in the IGF-I gene influences the age-related decline in circulating total IGF-I levels.
European journal of endocrinology / European Federation of Endocrine Societies 2003;148(2):171-5.
2003: Ingrid Rietveld; Joop A M J L Janssen; Cornelia M Van Duijn; Steven W J Lamberts
A polymorphic CA repeat in the promoter region of the insulin-like growth factor-I (IGF-I) gene.
European journal of epidemiology 2003;18(3):191-3.
2003: Annewieke W van den Beld; Michiel Bots; Joop A M J L Janssen; Huibert A P Pols; Steven W J Lamberts; Diederick Grobbee
Endogenous hormones and carotid atherosclerosis in elderly men.
American journal of epidemiology 2003;157(1):25-31.
2002: Elisabeth F C van Rossum; Jan W Koper; Nannette A T M Huizenga; André G Uitterlinden; Joop A M J L Janssen; Albert O Brinkmann; Diederick Grobbee; Frank de Jong; Cornelia M van Duyn; Huibert A P Pols; Steven W J Lamberts
A polymorphism in the glucocorticoid receptor gene, which decreases sensitivity to glucocorticoids in vivo, is associated with low insulin and cholesterol levels.
Diabetes 2002;51(10):3128-34.
2002: Fanny M van der Toorn; Joop A M J L Janssen; Wouter W de Herder; Fabio Broglio; Ezio Ghigo; Aart Jan Van der Lely
Central ghrelin production does not substantially contribute to systemic ghrelin concentrations: a study in two subjects with active acromegaly.
European journal of endocrinology / European Federation of Endocrine Societies 2002;147(2):195-9.
2002: F de Groof; Koen F M Joosten; Joop A M J L Janssen; Ester D De Kleijn; Jan A Hazelzet; W C J Hop; Piet Uitterlinden; Jaap van Doorn; Anita C S Hokken-Koelega
Acute stress response in children with meningococcal sepsis: important differences in the growth hormone/insulin-like growth factor I axis between nonsurvivors and survivors.
The Journal of clinical endocrinology and metabolism 2002;87(7):3118-24.
2002: Gianluca Aimaretti; Claudia Baffoni; Fabio Broglio; Joop A M J L Janssen; Ginevra Corneli; Romano Deghenghi; Aart Jan Van der Lely; Ezio Ghigo; Emanuela Arvat
Endocrine responses to ghrelin in adult patients with isolated childhood-onset growth hormone deficiency.
Clinical endocrinology 2002;56(6):765-71.
2002: P van Wijngaarden; Joop A M J L Janssen; R A de Man
[Hepatocellular carcinoma complicated by non-islet cell tumor hypoglycemia].
Nederlands tijdschrift voor geneeskunde 2002;146(18):859-62.
2002: Joop A M J L Janssen; Steven W J Lamberts
The role of IGF-I in the development of cardiovascular disease in type 2 diabetes mellitus: is prevention possible?
European journal of endocrinology / European Federation of Endocrine Societies 2002;146(4):467-77.
2002: Norbert Vaessen; Joop A M J L Janssen; Peter Heutink; Albert Hofman; Steven W J Lamberts; Ben A Oostra; Huibert A P Pols; C.M. Duijn
Association between genetic variation in the gene for insulin-like growth factor-I and low birthweight.
Lancet 2002;359(9311):1036-7.
2002: Alex F Muller; Steven W J Lamberts; Joop A M J L Janssen; Leo J Hofland; Peter Van Koetsveld; Martin Bidlingmaier; Christian J Strasburger; Ezio Ghigo; Aart Jan Van der Lely
Ghrelin drives GH secretion during fasting in man.
European journal of endocrinology / European Federation of Endocrine Societies 2002;146(2):203-7.
2001: Joop A M J L Janssen; F M van der Toorn; Leo J Hofland; Peter M Van Koetsveld; Fabio Broglio; Ezio Ghigo; S W Lamberts; A Jan van der Lely
Systemic ghrelin levels in subjects with growth hormone deficiency are not modified by one year of growth hormone replacement therapy.
European journal of endocrinology / European Federation of Endocrine Societies 2001;145(6):711-6.
2001: Alex F Muller; F W Leebeek; Joop A M J L Janssen; Steven W J Lamberts; Leo J Hofland; Aart Jan Van der Lely
Acute effect of pegvisomant on cardiovascular risk markers in healthy men: implications for the pathogenesis of atherosclerosis in GH deficiency.
The Journal of clinical endocrinology and metabolism 2001;86(11):5165-71.
2001: Alex F Muller; Joop A M J L Janssen; Steven W J Lamberts; Martin Bidlingmaier; Christian J Strasburger; Leo J Hofland; Aart Jan Van der Lely
Effects of fasting and pegvisomant on the GH-releasing hormone and GH-releasing peptide-6 stimulated growth hormone secretion.
Clinical endocrinology 2001;55(4):461-7.
2001: Norbert Vaessen; Peter Heutink; Joop A M J L Janssen; Jacqueline C M Witteman; Leon Testers; Albert Hofman; Steven W J Lamberts; Ben A Oostra; Huibert A P Pols; C.M. Duijn
A polymorphism in the gene for IGF-I: functional properties and risk for type 2 diabetes and myocardial infarction.
Diabetes 2001;50(3):637-42.
2001: Alex F Muller; Joop A M J L Janssen; Leo J Hofland; Steven W J Lamberts; Martin Bidlingmaier; Christian J Strasburger; Aart Jan Van der Lely
Blockade of the growth hormone (GH) receptor unmasks rapid GH-releasing peptide-6-mediated tissue-specific insulin resistance.
The Journal of clinical endocrinology and metabolism 2001;86(2):590-3.
2001: Aart Jan Van der Lely; A Muller; Joop A M J L Janssen; R J Davis; KA Zib; JA Scarlett; Steven W J Lamberts
Control of tumor size and disease activity during cotreatment with octreotide and the growth hormone receptor antagonist pegvisomant in an acromegalic patient.
The Journal of clinical endocrinology and metabolism 2001;86(2):478-81.
2001: Alex F Muller; Joop A M J L Janssen; Wouter W de Herder; Aart Jan Van der Lely
[Growth hormone receptor antagonists: potential indications].
Nederlands tijdschrift voor geneeskunde 2001;145(2):69-73.
2000: S Kalmijn; Joop A M J L Janssen; Huibert A P Pols; Steven W J Lamberts; Monique Breteler
A prospective study on circulating insulin-like growth factor I (IGF-I), IGF-binding proteins, and cognitive function in the elderly.
The Journal of clinical endocrinology and metabolism 2000;85(12):4551-5.
2000: Joop A M J L Janssen; Steven W J Lamberts
Circulating IGF-I and its protective role in the pathogenesis of diabetic angiopathy.
Clinical endocrinology 2000;52(1):1-9.
1999: Joop A M J L Janssen; Steven W J Lamberts
Is the measurement of free IGF-I more indicative than that of total IGF-I in the evaluation of the biological activity of the GH/IGF-I axis?
Journal of endocrinological investigation 1999;22(4):313-5.
1998: Joop A M J L Janssen; N Hoogerbrugge; Johan W van Neck; Piet Uitterlinden; Steven W J Lamberts
The IGF-I/IGFBP system in congenital partial lipodystrophy.
Clinical endocrinology 1998;49(4):465-73.
1998: Joop A M J L Janssen; Jan W Koper; RP Stolk; P Englaro; André G Uitterlinden; Q Huang; Johannes P T M van Leeuwen; Werner F Blum; A M Attanasio; Huibert A P Pols; Diederick Grobbee; Frank de Jong; Steven W J Lamberts
Lack of associations between serum leptin, a polymorphism in the gene for the beta 3-adrenergic receptor and glucose tolerance in the Dutch population.
Clinical endocrinology 1998;49(2):229-34.
1998: Joop A M J L Janssen; H Burger; R P Stolk; Diederick Grobbee; Frank de Jong; Steven W J Lamberts; Huibert A P Pols
Gender-specific relationship between serum free and total IGF-I and bone mineral density in elderly men and women.
European journal of endocrinology / European Federation of Endocrine Societies 1998;138(6):627-32.
1998: Joop A M J L Janssen; Nannette A T M Huizenga; RP Stolk; Diederick Grobbee; Huibert A P Pols; Frank de Jong; A M Attanasio; Werner F Blum; Steven W J Lamberts
The acute effect of dexamethasone on plasma leptin concentrations and the relationships between fasting leptin, the IGF-I/IGFBP system, dehydroepiandrosterone, androstenedione and testosterone in an elderly population.
Clinical endocrinology 1998;48(5):621-6.
1998: Joop A M J L Janssen; RP Stolk; Huibert A P Pols; Diederick Grobbee; Frank de Jong; Steven W J Lamberts
Serum free IGF-I, total IGF-I, IGFBP-1 and IGFBP-3 levels in an elderly population: relation to age and sex steroid levels.
Clinical endocrinology 1998;48(4):471-8.
1998: Joop A M J L Janssen; Piet Uitterlinden; Leo J Hofland; Steven W J Lamberts
Insulin-like growth factor I receptors on blood cells: their relationship to circulating total and "free" IGF-I, IGFBP-1, IGFBP-3 and insulin levels in healthy subjects.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 1998;8(1):47-54.
1998: Joop A M J L Janssen; RP Stolk; Huibert A P Pols; Diederick Grobbee; Steven W J Lamberts
Serum total IGF-I, free IGF-I, and IGFB-1 levels in an elderly population: relation to cardiovascular risk factors and disease.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(2):277-82.
1998: Joop A M J L Janssen; RP Stolk; Huibert A P Pols; Diederick Grobbee; Steven W J Lamberts
Serum free and total insulin-like growth factor-I, insulin-like growth factor binding protein-1 and insulin-like growth factor binding protein-3 Levels in healthy elderly individuals. Relation to self-reported quality of health and disability.
Gerontology 1998;44(5):277-80.
1997: Joop A M J L Janssen; M L Jacobs; Frans H M Derkx; R F A Weber; Aart Jan Van der Lely; Steven W J Lamberts
Free and total insulin-like growth factor I (IGF-I), IGF-binding protein-1 (IGFBP-1), and IGFBP-3 and their relationships to the presence of diabetic retinopathy and glomerular hyperfiltration in insulin-dependent diabetes mellitus.
The Journal of clinical endocrinology and metabolism 1997;82(9):2809-15.
1995: Wouter W de Herder; A J van der Lely; Joop A M J L Janssen; Piet Uitterlinden; Leo Hofland; Steven W J Lamberts
IGFBP-3 is a poor parameter for assessment of clinical activity in acromegaly.
Clinical endocrinology 1995;43(4):501-5.
1995: Anton H van den Meiracker; P J Admiraal; Joop A M J L Janssen; J M Kroodsma; W A de Ronde; Frans Boomsma; J Sissmann; P J Blankestijn; P G Mulder; AJ Man in 't Veld
Hemodynamic and biochemical effects of the AT1 receptor antagonist irbesartan in hypertension.
Hypertension 1995;25(1):22-9.
1992: A A Franken; Frans H M Derkx; P J Blankestijn; Joop A M J L Janssen; C K Mannesse; W Hop; Frans Boomsma; R Weber; E Peperkamp; Paulus T V M de Jong
Plasma prorenin as an early marker of microvascular disease in patients with diabetes mellitus.
Diabète & métabolisme 1992;18(2 Pt 2):137-43.
1991: Joop A M J L Janssen; H L Tjiong
Bronchial asthma improved after removal of a phaeochromocytoma.
The European respiratory journal 1991;4(8):1021-2.
1989: Joop A M J L Janssen; P J Blankestijn; Roel Docter; B G Blijenberg; S W Lamberts; E P Krenning
[The effect of immunoscintigraphy with monoclonal antibodies on assays of hormones and tumor markers. This is not the end of the matter!].
Nederlands tijdschrift voor geneeskunde 1989;133(29):1455-8.
1989: Joop A M J L Janssen; P J Blankestijn; Roel Docter; B G Blijenberg; T A Splinter; Hans van Toor; Maarten A D H Schalekamp; S W Lamberts; E P Krenning
Effects of immunoscintigraphy with monoclonal antibodies in assays of hormones and tumour markers.
BMJ (Clinical research ed.) 1989;298(6686):1511-3.