FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Paul Janssen

Research Profile

Chemicals & Drugs

Living Beings

Concepts & Ideas

Occupations

Drug Design

Co-author Network

Publications

TOP 3
Marc R. de Jonge; Lucien M H Koymans; H Maarten Vinkers; Frits Daeyaert; Jan Heeres; Paul J Lewi; Paul A J Janssen
Structure based activity prediction of HIV-1 reverse transcriptase inhibitors.
Jérôme Guillemont; Elisabeth Pasquier; Patrice Palandjian; Daniel Vernier; Sandrine Gaurrand; Paul J Lewi; Jan Heeres; Marc R. de Jonge; Lucien M H Koymans; Frits Daeyaert; Maarten Vinkers; Eddy Arnold; Kalyan Das; Rudi Pauwels; Koen Andries; Marie-Pierre de Bethune; Eva Bettens; Kurt Hertogs; Piet Wigerinck; Philip Timmerman; Paul A J Janssen
Synthesis of novel diarylpyrimidine analogues and their antiviral activity against human immunodeficiency virus type 1.
Yulia Volovik Frenkel; Arthur D Clark; Kalyan Das; Yuh-Hwa Wang; Paul J Lewi; Paul A J Janssen; Eddy Arnold
Concentration and pH dependent aggregation of hydrophobic drug molecules and relevance to oral bioavailability.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Paul Janssen (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2005: Marc R. de Jonge; Lucien M H Koymans; H Maarten Vinkers; Frits Daeyaert; Jan Heeres; Paul J Lewi; Paul A J Janssen
Structure based activity prediction of HIV-1 reverse transcriptase inhibitors.
Journal of medicinal chemistry 2005;48(6):2176-83.
2005: Jérôme Guillemont; Elisabeth Pasquier; Patrice Palandjian; Daniel Vernier; Sandrine Gaurrand; Paul J Lewi; Jan Heeres; Marc R. de Jonge; Lucien M H Koymans; Frits Daeyaert; Maarten Vinkers; Eddy Arnold; Kalyan Das; Rudi Pauwels; Koen Andries; Marie-Pierre de Bethune; Eva Bettens; Kurt Hertogs; Piet Wigerinck; Philip Timmerman; Paul A J Janssen
Synthesis of novel diarylpyrimidine analogues and their antiviral activity against human immunodeficiency virus type 1.
Journal of medicinal chemistry 2005;48(6):2072-9.
2005: Yulia Volovik Frenkel; Arthur D Clark; Kalyan Das; Yuh-Hwa Wang; Paul J Lewi; Paul A J Janssen; Eddy Arnold
Concentration and pH dependent aggregation of hydrophobic drug molecules and relevance to oral bioavailability.
Journal of medicinal chemistry 2005;48(6):1974-83.
2005: Jan Heeres; Marc R. de Jonge; Lucien M H Koymans; Frits Daeyaert; Maarten Vinkers; Koen J A Van Aken; Eddy Arnold; Kalyan Das; Amuri Kilonda; Georges J Hoornaert; Frans Compernolle; Marek Cegla; Rasha A Azzam; Koen Andries; Marie-Pierre de Bethune; Hilde Azijn; Rudi Pauwels; Paul J Lewi; Paul A J Janssen
Design, synthesis, and SAR of a novel pyrazinone series with non-nucleoside HIV-1 reverse transcriptase inhibitory activity.
Journal of medicinal chemistry 2005;48(6):1910-8.
2005: Paul A J Janssen; Paul J Lewi; Eddy Arnold; Frits Daeyaert; Marc de Jonge; Jan Heeres; Lucien M H Koymans; Maarten Vinkers; Jérôme Guillemont; Elisabeth Pasquier; Michael J Kukla; Donald W Ludovici; Koen Andries; Marie-Pierre de Bethune; Rudi Pauwels; Kalyan Das; Arthur D Clark; Yulia Volovik Frenkel; Stephen H Hughes; Bart Medaer; Fons De Knaep; Hilde Bohets; Fred De Clerck; Ann Lampo; Peter Williams; Paul Stoffels
In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, rilpivirine).
Journal of medicinal chemistry 2005;48(6):1901-9.
2005: Harr F Njai; Paul J Lewi; Cornelus G M Janssen; Sergio Garcia; Katrien Fransen; Luc Kestens; Guido Vanham; Paul A J Janssen
Pre-incubation of cell-free HIV-1 group M isolates with non-nucleoside reverse transcriptase inhibitors blocks subsequent viral replication in co-cultures of dendritic cells and T cells.
Antiviral therapy 2005;10(2):255-62.
2004: Kalyan Das; Arthur D Clark; Paul J Lewi; Jan Heeres; Marc R. de Jonge; Lucien M H Koymans; H Maarten Vinkers; Frits Daeyaert; Donald W Ludovici; Michael J Kukla; Bart De Corte; Robert W Kavash; Chih Y Ho; Hong Ye; Mark A Lichtenstein; Koen Andries; Rudi Pauwels; Marie-Pierre de Bethune; Paul L Boyer; Patrick Clark; Stephen H Hughes; Paul A J Janssen; Eddy Arnold
Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants.
Journal of medicinal chemistry 2004;47(10):2550-60.
2004: Michal Daszykowski; Beata Walczak; Q-S Xu; Frits Daeyaert; Marc R. de Jonge; Jan Heeres; Lucien M H Koymans; Paul J Lewi; H Maarten Vinkers; Paul A J Janssen; D Luc Massart
Classification and regression trees--studies of HIV reverse transcriptase inhibitors.
Journal of chemical information and computer sciences 2004;44(2):716-26.
2004: Frits Daeyaert; Marc de Jonge; Jan Heeres; Lucien M H Koymans; Paul J Lewi; Maarten Vinkers; Paul A J Janssen
A pharmacophore docking algorithm and its application to the cross-docking of 18 HIV-NNRTI's in their binding pockets.
Proteins 2004;54(3):526-33.
2004: Paul J Lewi; Eddy Arnold; Koen Andries; Hilde Bohets; Herman Borghys; Arthur Clark; Frits Daeyaert; Kalyan Das; Marie-Pierre de Bethune; Marc de Jonge; Jan Heeres; Lucien M H Koymans; Jos Leempoels; Jef Peeters; Philip Timmerman; Walter Van den Broeck; Frédéric Vanhoutte; Gerben Van't Klooster; Maarten Vinkers; Yulia Volovik; Paul A J Janssen
Correlations between factors determining the pharmacokinetics and antiviral activity of HIV-1 non-nucleoside reverse transcriptase inhibitors of the diaryltriazine and diarylpyrimidine classes of compounds.
Drugs in R&D 2004;5(5):245-57.
2003: H Maarten Vinkers; Marc R. de Jonge; E D Daeyaert; Jan Heeres; Lucien M H Koymans; Joop H van Lenthe; Paul J Lewi; H Timmerman; Paul A J Janssen
Inhibition and substrate recognition--a computational approach applied to HIV protease.
Journal of computer-aided molecular design 2003;17(9):567-81.
2003: H Maarten Vinkers; Marc R. de Jonge; Frits Daeyaert; Jan Heeres; Lucien M H Koymans; Joop H van Lenthe; Paul J Lewi; Henk Timmerman; Koen J A Van Aken; Paul A J Janssen
SYNOPSIS: SYNthesize and OPtimize System in Silico.
Journal of medicinal chemistry 2003;46(13):2765-73.
2003: Paul J Lewi; Marc de Jonge; Frits Daeyaert; Lucien M H Koymans; Maarten Vinkers; Jan Heeres; Paul A J Janssen; Eddy Arnold; Kalyan Das; Arthur D Clark; Stephen H Hughes; Paul L Boyer; Marie-Pierre de Bethune; Rudi Pauwels; Koen Andries; Michael J Kukla; Donald W Ludovici; Bart De Corte; Robert W Kavash; Chih Ho; Paul J Lewis
On the detection of multiple-binding modes of ligands to proteins, from biological, structural, and modeling data.
Journal of computer-aided molecular design 2003;17(2-4):129-34.
2001: Donald W Ludovici; Bart De Corte; Michael J Kukla; Hong Ye; Chih Y Ho; M A Lichtenstein; Robert W Kavash; Koen Andries; Marie-Pierre de Bethune; Hilde Azijn; Rudi Pauwels; Paul J Lewi; Jan Heeres; Lucien M H Koymans; Marc R. de Jonge; Koen J A Van Aken; Frits Daeyaert; Kalyan Das; Eddy Arnold; Paul A J Janssen
Evolution of anti-HIV drug candidates. Part 3: Diarylpyrimidine (DAPY) analogues.
Bioorganic & medicinal chemistry letters 2001;11(17):2235-9.
2001: Donald W Ludovici; Robert W Kavash; Michael J Kukla; Chih Y Ho; Hong Ye; Bart De Corte; Koen Andries; Marie-Pierre de Bethune; Hilde Azijn; Rudi Pauwels; HE Moereels; Jan Heeres; Lucien M H Koymans; Marc R. de Jonge; Koen J A Van Aken; Frits Daeyaert; Paul J Lewi; Kalyan Das; Eddy Arnold; Paul A J Janssen
Evolution of anti-HIV drug candidates. Part 2: Diaryltriazine (DATA) analogues.
Bioorganic & medicinal chemistry letters 2001;11(17):2229-34.
2001: Donald W Ludovici; Michael J Kukla; P G Grous; S Krishnan; Koen Andries; Marie-Pierre de Bethune; Hilde Azijn; Rudi Pauwels; E De Clercq; Eddy Arnold; Paul A J Janssen
Evolution of anti-HIV drug candidates. Part 1: From alpha-anilinophenylacetamide (alpha-APA) to imidoyl thiourea (ITU).
Bioorganic & medicinal chemistry letters 2001;11(17):2225-8.
2001: Y Hsiou; Jianping Ding; Kalyan Das; Arthur D Clark; Paul L Boyer; Paul J Lewi; Paul A J Janssen; JP Kleim; M Rösner; Stephen H Hughes; Eddy Arnold
The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance.
Journal of molecular biology 2001;309(2):437-45.
1999: Henry J Breslin; Michael J Kukla; T Kromis; H Cullis; F De Knaep; Rudi Pauwels; Koen Andries; E De Clercq; M A Janssen; Paul A J Janssen
Synthesis and anti-HIV activity of 1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one (TBO) derivatives. Truncated 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2( 1H)-on es (TIBO) analogues.
Bioorganic & medicinal chemistry 1999;7(11):2427-36.
1998: Richard H Smith; William L Jorgensen; Julian Tirado-Rives; ML Lamb; Paul A J Janssen; Christopher J Michejda; Marilyn B Kroeger Smith
Prediction of binding affinities for TIBO inhibitors of HIV-1 reverse transcriptase using Monte Carlo simulations in a linear response method.
Journal of medicinal chemistry 1998;41(26):5272-86.
1997: Marilyn B Kroeger Smith; Christopher J Michejda; Stephen H Hughes; Paul L Boyer; Paul A J Janssen; Koen Andries; Robert W Buckheit; Richard H Smith
Molecular modeling of HIV-1 reverse transcriptase drug-resistant mutant strains: implications for the mechanism of polymerase action.
Protein engineering 1997;10(12):1379-83.
1996: Kalyan Das; J Ding; Y Hsiou; Arthur D Clark; HE Moereels; L Koymans; Koen Andries; R Pauwels; Paul A J Janssen; Paul L Boyer; P Clark; Richard H Smith; Marilyn B Kroeger Smith; Christopher J Michejda; Stephen H Hughes; Eddy Arnold
Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant.
Journal of molecular biology 1996;264(5):1085-100.
1996: HE Moereels; Paul J Lewi; L M Koymans; Paul A J Janssen
The alpha and omega of G-protein coupled receptors: a novel method for classification. Part 1.
Receptors & channels 1996;4(1):19-30.
1995: Marilyn B Kroeger Smith; C A Rouzer; Lisa Anne Taneyhill; N A Smith; Stephen H Hughes; Paul L Boyer; Paul A J Janssen; HE Moereels; L Koymans; Eddy Arnold
Molecular modeling studies of HIV-1 reverse transcriptase nonnucleoside inhibitors: total energy of complexation as a predictor of drug placement and activity.
Protein science : a publication of the Protein Society 1995;4(10):2203-22.
1995: J Ding; Kalyan Das; HE Moereels; L Koymans; Koen Andries; Paul A J Janssen; Stephen H Hughes; Eddy Arnold
Structure of HIV-1 RT/TIBO R 86183 complex reveals similarity in the binding of diverse nonnucleoside inhibitors.
Nature structural biology 1995;2(5):407-15.
1994: C Tantillo; J Ding; A Jacobo-Molina; R G Nanni; Paul L Boyer; Stephen H Hughes; R Pauwels; Koen Andries; Paul A J Janssen; Eddy Arnold
Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. Implications for mechanisms of drug inhibition and resistance.
Journal of molecular biology 1994;243(3):369-87.
1994: Paul A J Janssen; F H Awouters
Is it possible to predict the clinical effects of neuroleptics from animal data? Part V: From haloperidol and pipamperone to risperidone.
Arzneimittel-Forschung 1994;44(3):269-77.
1994: Paul A J Janssen
Addiction and the potential for therapeutic drug development.
EXS 1994;71():361-70.
1993: F Awouters; Anton Megens; M Verlinden; Jan A J Schuurkes; C Niemegeers; Paul A J Janssen
Loperamide. Survey of studies on mechanism of its antidiarrheal activity.
Digestive diseases and sciences 1993;38(6):977-95.
1992: D de Cheffoy de Courcelles; K de Loore; E Freyne; Paul A J Janssen
Inhibition of human cardiac cyclic AMP-phosphodiesterases by R 80122, a new selective cyclic AMP-phosphodiesterase III inhibitor: a comparison with other cardiotonic compounds.
The Journal of pharmacology and experimental therapeutics 1992;263(1):6-14.
1992: H Van Belle; W Verheyen; K Ver Donck; Paul A J Janssen; J I Robertson
Prevention of catecholamine-induced cardiac damage and death with a nucleoside transport inhibitor.
Journal of cardiovascular pharmacology 1992;20(2):173-8.
1992: J Van Wauwe; G Van Nyen; M C Coene; P Stoppie; W Cools; J Goossens; P Borghgraef; Paul A J Janssen
Liarozole, an inhibitor of retinoic acid metabolism, exerts retinoid-mimetic effects in vivo.
The Journal of pharmacology and experimental therapeutics 1992;261(2):773-9.
1992: D Ashton; J Fransen; J Heeres; G Clincke; Paul A J Janssen
In vivo studies on the mechanism of action of the broad spectrum anticonvulsant loreclezole.
Epilepsy research 1992;11(1):27-36.
1992: Hugo F Vanden Bossche; G Willemsens; D Bellens; Paul A J Janssen
Ridogrel: a selective inhibitor of the cytochrome P450-dependent thromboxane synthesis.
Biochemical pharmacology 1992;43(4):739-44.
1992: R Van Ginckel; W Distelmans; M De Brabander; M Callens; B Janssens; E Jagers; Luc Wouters; R De Coster; Paul A J Janssen
Levamisole plus 5-fluorouracil inhibits the growth of human colorectal xenografts in nude mice.
European journal of cancer (Oxford, England : 1990) 1992;28A(6-7):1137-9.
1992: Anton Megens; F H Awouters; T F Meert; K H Schellekens; C J Niemegeers; Paul A J Janssen
Pharmacological profile of the new potent neuroleptic ocaperidone (R 79,598).
The Journal of pharmacology and experimental therapeutics 1992;260(1):146-59.
1992: F Awouters; C J Niemegeers; T Jansen; Anton Megens; Paul A J Janssen
Levocabastine: pharmacological profile of a highly effective inhibitor of allergic reactions.
Agents and actions 1992;35(1-2):12-8.
1992: Koen Andries; B Dewindt; J Snoeks; Rudy Willebrords; K van Eemeren; R Stokbroekx; Paul A J Janssen
In vitro activity of pirodavir (R 77975), a substituted phenoxy-pyridazinamine with broad-spectrum antipicornaviral activity.
Antimicrobial agents and chemotherapy 1992;36(1):100-7.
1991: T F Meert; F Awouters; C J Niemegeers; K H Schellekens; Paul A J Janssen
Ritanserin reduces abuse of alcohol, cocaine, and fentanyl in rats.
Pharmacopsychiatry 1991;24(5):159-63.
1991: J Van Cutsem; F Van Gerven; Geert Cauwenbergh; Frank C Odds; Paul A J Janssen
The antiinflammatory effects of ketoconazole. A comparative study with hydrocortisone acetate in a model using living and killed Staphylococcus aureus on the skin of guinea-pigs.
Journal of the American Academy of Dermatology 1991;25(2 Pt 1):257-61.
1991: Paul A J Janssen
Levamisole as an adjuvant in cancer treatment.
Journal of clinical pharmacology 1991;31(5):396-400.
1991: M D Krekels; Walter Wouters; R De Coster; R Van Ginckel; A Leonaers; Paul A J Janssen
Aromatase in the human choriocarcinoma JEG-3: inhibition by R 76 713 in cultured cells and in tumors grown in nude mice.
The Journal of steroid biochemistry and molecular biology 1991;38(4):415-22.
1991: J Van Wauwe; Paul A J Janssen
On the biochemical mode of action of levamisole: an update.
International journal of immunopharmacology 1991;13(1):3-9.
1991: J Van Wauwe; M C Coene; G Van Nyen; W Cools; J Goossens; L Le Jeune; W Lauwers; Paul A J Janssen
NADPH-dependent formation of 15- and 12-hydroxyeicosatrienoic acid from arachidonic acid by rat epidermal microsomes.
Eicosanoids 1991;4(3):155-63.
1990: R De Coster; Walter Wouters; C R Bowden; Hugo F Vanden Bossche; J Bruynseels; R W Tuman; R Van Ginckel; Eric Snoeck; Achiel Van Peer; Paul A J Janssen
New non-steroidal aromatase inhibitors: focus on R76713.
The Journal of steroid biochemistry and molecular biology 1990;37(3):335-41.
1990: M De Ryck; H Duytschaever; Petrus J Pauwels; Paul A J Janssen
Ionic channels, cholinergic mechanisms, and recovery of sensorimotor function after neocortical infarcts in rats.
Stroke; a journal of cerebral circulation 1990;21(11 Suppl):III158-63.
1990: Hugo F Vanden Bossche; G Willemsens; I Roels; D Bellens; HE Moereels; M C Coene; L Le Jeune; W Lauwers; Paul A J Janssen
R 76713 and enantiomers: selective, nonsteroidal inhibitors of the cytochrome P450-dependent oestrogen synthesis.
Biochemical pharmacology 1990;40(8):1707-18.
1990: D Ashton; R Willems; Roger Marrannes; Paul A J Janssen
Extracellular ions during veratridine-induced neurotoxicity in hippocampal slices: neuroprotective effects of flunarizine and tetrodotoxin.
Brain research 1990;528(2):212-22.
1990: F Awouters; C J Niemegeers; Anton Megens; Paul A J Janssen
Functional interaction between serotonin-S2 and dopamine-D2 neurotransmission as revealed by selective antagonism of hyper-reactivity to tryptamine and apomorphine.
The Journal of pharmacology and experimental therapeutics 1990;254(3):945-51.
1990: Hugo F Vanden Bossche; Patrick Marichal; G Willemsens; D Bellens; J Gorrens; I Roels; M C Coene; L Le Jeune; Paul A J Janssen
Saperconazole: a selective inhibitor of the cytochrome P-450-dependent ergosterol synthesis in Candida albicans, Aspergillus fumigatus and Trichophyton mentagrophytes.
Mycoses 1990;33(7-8):335-52.
1990: J Van Cutsem; F Van Gerven; J Fransen; P Schrooten; Paul A J Janssen
The in vitro antifungal activity of ketoconazole, zinc pyrithione, and selenium sulfide against Pityrosporum and their efficacy as a shampoo in the treatment of experimental pityrosporosis in guinea pigs.
Journal of the American Academy of Dermatology 1990;22(6 Pt 1):993-8.
1990: Koen Andries; B Dewindt; J Snoeks; Luc Wouters; HE Moereels; Paul J Lewi; Paul A J Janssen
Two groups of rhinoviruses revealed by a panel of antiviral compounds present sequence divergence and differential pathogenicity.
Journal of virology 1990;64(3):1117-23.
1990: C J Niemegeers; F Awouters; Paul A J Janssen
[Serotonin antagonism involved in the antipsychotic effect. Confirmation with ritanserine and risperidone].
L'Encéphale 1990;16(2):147-51.
1990: Hugo F Vanden Bossche; Patrick Marichal; J Gorrens; D Bellens; HE Moereels; Paul A J Janssen
Mutation in cytochrome P-450-dependent 14 alpha-demethylase results in decreased affinity for azole antifungals.
Biochemical Society transactions 1990;18(1):56-9.
1990: Hugo F Vanden Bossche; G Willemsens; D Bellens; I Roels; Paul A J Janssen
From 14 alpha-demethylase inhibitors in fungal cells to androgen and oestrogen biosynthesis inhibitors in mammalian cells.
Biochemical Society transactions 1990;18(1):10-3.
1990: F Awouters; C J Niemegeers; Paul A J Janssen
'Tardive' dyskinesia: etiological and therapeutic aspects.
Pharmacopsychiatry 1990;23(1):33-7.
1989: J Van Cutsem; F Van Gerven; Paul A J Janssen
Oral and parenteral therapy with saperconazole (R 66905) of invasive aspergillosis in normal and immunocompromised animals.
Antimicrobial agents and chemotherapy 1989;33(12):2063-8.
1989: C Dugovic; A Wauquier; Paul A J Janssen
Differential effects of the new antipsychotic risperidone on sleep and wakefulness in the rat.
Neuropharmacology 1989;28(12):1431-3.
1989: M De Ryck; Jos Van Reempts; M Borgers; A Wauquier; Paul A J Janssen
Photochemical stroke model: flunarizine prevents sensorimotor deficits after neocortical infarcts in rats.
Stroke; a journal of cerebral circulation 1989;20(10):1383-90.
1989: J P Van Wauwe; Paul A J Janssen
Is there a case for P-450 inhibitors in cancer treatment?
Journal of medicinal chemistry 1989;32(10):2231-9.
1989: A Wauquier; W Melis; Paul A J Janssen
Long-term neurological assessment of the post-resuscitative effects of flunarizine, verapamil and nimodipine in a new model of global complete ischaemia.
Neuropharmacology 1989;28(8):837-46.
1989: Paul A J Janssen; H Janssen; Geert Cauwenbergh; PR De Doncker; K De Beule; Paul J Lewi; H F Tytgat; C M Lapière
Use of topical ketanserin in the treatment of skin ulcers: a double-blind study.
Journal of the American Academy of Dermatology 1989;21(1):85-90.
1989: Walter Wouters; R De Coster; R W Tuman; C R Bowden; J Bruynseels; H Vanderpas; P Van Rooy; W K Amery; Paul A J Janssen
Aromatase inhibition by R 76713: experimental and clinical pharmacology.
Journal of steroid biochemistry 1989;34(1-6):427-30.
1989: Hugo F Vanden Bossche; Patrick Marichal; J Gorrens; M C Coene; G Willemsens; D Bellens; I Roels; HE Moereels; Paul A J Janssen
Biochemical approaches to selective antifungal activity. Focus on azole antifungals.
Mycoses 1989;32 Suppl 1():35-52.
1989: J Van Cutsem; F Van Gerven; J Fransen; Paul A J Janssen
Treatment of experimental zygomycosis in guinea pigs with azoles and with amphotericin B.
Chemotherapy 1989;35(4):267-72.
1989: C Dugovic; A Wauquier; Josée E Leysen; Roger Marrannes; Paul A J Janssen
Functional role of 5-HT2 receptors in the regulation of sleep and wakefulness in the rat.
Psychopharmacology 1989;97(4):436-42.
1989: T F Meert; P de Haes; Paul A J Janssen
Risperidone (R 64 766), a potent and complete LSD antagonist in drug discrimination by rats.
Psychopharmacology 1989;97(2):206-12.
1988: J Van Cutsem; F Van Gerven; Paul A J Janssen
In vitro activity of enilconazole against Aspergillus spp. and its fungicidal efficacy in a smoke generator against Aspergillus fumigatus.
Mycoses 1988;31(3):143-7.
1988: Paul A J Janssen; C J Niemegeers; F Awouters; K H Schellekens; Anton Megens; T F Meert
Pharmacology of risperidone (R 64 766), a new antipsychotic with serotonin-S2 and dopamine-D2 antagonistic properties.
The Journal of pharmacology and experimental therapeutics 1988;244(2):685-93.
1988: G Clincke; L Tritsmans; C Idzikowski; W K Amery; Paul A J Janssen
The effect of R 58 735 (Sabeluzole) on memory functions in healthy elderly volunteers.
Psychopharmacology 1988;94(1):52-7.
1988: Hugo F Vanden Bossche; G Willemsens; Paul A J Janssen
Cytochrome-P-450-dependent metabolism of retinoic acid in rat skin microsomes: inhibition by ketoconazole.
Skin pharmacology : the official journal of the Skin Pharmacology Society 1988;1(3):176-85.
1988: Hugo F Vanden Bossche; Patrick Marichal; J Gorrens; Hugo Geerts; Paul A J Janssen
Mode of action studies. Basis for the search of new antifungal drugs.
Annals of the New York Academy of Sciences 1988;544():191-207.
1988: Koen Andries; B Dewindt; M De Brabander; R Stokbroekx; Paul A J Janssen
In vitro activity of R 61837, a new antirhinovirus compound.
Archives of virology 1988;101(3-4):155-67.
1987: A Wauquier; H Van Belle; W A Van den Broeck; Paul A J Janssen
Sleep improvement in dogs after oral administration of mioflazine, a nucleoside transport inhibitor.
Psychopharmacology 1987;91(4):434-9.
1987: J Van Cutsem; F Van Gerven; Paul A J Janssen
Activity of orally, topically, and parenterally administered itraconazole in the treatment of superficial and deep mycoses: animal models.
Reviews of infectious diseases 1987;9 Suppl 1():S15-32.
1987: J Van Cutsem; F Van Gerven; Paul A J Janssen
[Anti-Candida activity of azoles].
Annales de biologie clinique 1987;45(6):661-8.
1986: C J Niemegeers; F Awouters; Paul A J Janssen
The pharmacological profile of a specific, safe, effective and non-sedative anti-allergic, astemizole.
Agents and actions 1986;18(1-2):141-4.
1985: J Van Cutsem; J Fransen; F Van Gerven; Paul A J Janssen
Oral treatment with ketoconazole in systemic candidosis of guinea-pigs: microbiology, hematology and histopathology.
Sabouraudia 1985;23(3):189-98.
1985: H L Edmonds; A Wauquier; W Melis; W A Van den Broeck; J Van Loon; Paul A J Janssen
Improved short-term neurological recovery with flunarizine in a canine model of cardiac arrest.
The American journal of emergency medicine 1985;3(2):150-5.
1985: F C Colpaert; T F Meert; C J Niemegeers; Paul A J Janssen
Behavioral and 5-HT antagonist effects of ritanserin: a pure and selective antagonist of LSD discrimination in rat.
Psychopharmacology 1985;86(1-2):45-54.
1984: J Van Cutsem; F Van Gerven; M A Van de Ven; Marcel Borgers; Paul A J Janssen
Itraconazole, a new triazole that is orally active in aspergillosis.
Antimicrobial agents and chemotherapy 1984;26(4):527-34.
1983: J Van Cutsem; F Van Gerven; R Zaman; Paul A J Janssen
Terconazole - a new broad-spectrum antifungal.
Chemotherapy 1983;29(5):322-31.
1983: F Awouters; C J Niemegeers; Paul A J Janssen
Pharmacology of antidiarrheal drugs.
Annual review of pharmacology and toxicology 1983;23():279-301.
1983: F H Awouters; C J Niemegeers; Paul A J Janssen
Pharmacology of the specific histamine H1-antagonist astemizole.
Arzneimittel-Forschung 1983;33(3):381-8.
1982: C J Niemegeers; F Awouters; F M Lenaerts; J Vermeire; Paul A J Janssen
Prevention of physostigmine-induced lethality in rats. A pharmacological analysis.
Archives internationales de pharmacodynamie et de thérapie 1982;259(1):153-65.
1981: A Wauquier; W A Van den Broeck; F Awouters; Paul A J Janssen
A comparison between astemizole and other antihistamines on sleep-wakefulness cycles in dogs.
Neuropharmacology 1981;20(9):853-9.
1981: C J Niemegeers; J C Levron; F Awouters; Paul A J Janssen
Inhibition and induction of microsomal enzymes in rat. A comparative study of four antimycotics: miconazole, econazole, clotrimazole and ketoconazole.
Archives internationales de pharmacodynamie et de thérapie 1981;251(1):26-38.
1980: A Wauquier; W A Van den Broeck; Paul A J Janssen
Biphasic effects of pimozide on sleep-wakefulness in dogs.
Life sciences 1980;27(16):1469-75.
1980: C J Niemegeers; K H Schellekens; Paul A J Janssen
The antiemetic effects of domperidone, a novel potent gastrokinetic.
Archives internationales de pharmacodynamie et de thérapie 1980;244(1):130-40.