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Velpandi Ayyavoo

Research Profile

Chemicals & Drugs

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HIV Infections

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Publications

TOP 3
Phalguni Gupta; Xioli Huang; Bruce Patterson; Dorothy L Patton; Bharat Ramratnam; Deena Ratner; Todd A Reinhart; Lisa C Rohan; Velpandi Ayyavoo; Ming Ding; Alexander M Cole
Retrocyclin RC-101 blocks HIV-1 transmission across cervical mucosa in an organ culture.
Rajeev Mehla; Velpandi Ayyavoo
Gene array studies in HIV-1 infection.
Debjani Guha; Pruthvi Nagilla; Carrie Redinger; Gerald P Schatten; Alagarsamy Srinivasan; Velpandi Ayyavoo
Neuronal apoptosis by HIV-1 Vpr: contribution of proinflammatory molecular networks from infected target cells.

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All Publications

2012: Phalguni Gupta; Xioli Huang; Bruce Patterson; Dorothy L Patton; Bharat Ramratnam; Deena Ratner; Todd A Reinhart; Lisa C Rohan; Velpandi Ayyavoo; Ming Ding; Alexander M Cole
Retrocyclin RC-101 blocks HIV-1 transmission across cervical mucosa in an organ culture.
Journal of acquired immune deficiency syndromes (1999) 2012;60(5):455-61.
2012: Rajeev Mehla; Velpandi Ayyavoo
Gene array studies in HIV-1 infection.
Current HIV/AIDS reports 2012;9(1):34-43.
2012: Debjani Guha; Pruthvi Nagilla; Carrie Redinger; Gerald P Schatten; Alagarsamy Srinivasan; Velpandi Ayyavoo
Neuronal apoptosis by HIV-1 Vpr: contribution of proinflammatory molecular networks from infected target cells.
Journal of neuroinflammation 2012;9():138.
2011: Ankit Gupta; Hai-Son Le; Sinnakaruppan Mathavan; Pruthvi Nagilla; Anbupalam Thalamuthu; Courtney Zych; Ziv Bar-Joseph; Coulton Bunney; Velpandi Ayyavoo
Comparative expression profile of miRNA and mRNA in primary peripheral blood mononuclear cells infected with human immunodeficiency virus (HIV-1).
PloS one 2011;6(7):e22730.
2010: Keri L Schaubert; David A Price; Janelle R Salkowitz; Andrew K Sewell; John Sidney; Tedi E Asher; Sylvie E Blondelle; Sharon Adams; Francesco M Marincola; Aviva Joseph; Alessandro Sette; Daniel C Douek; Velpandi Ayyavoo; Walter Storkus; Ming-Ying Leung; Hwee L Ng; Otto O Yang; Harris Goldstein; Darcy B Wilson; June Kan-Mitchell
Generation of robust CD8+ T-cell responses against subdominant epitopes in conserved regions of HIV-1 by repertoire mining with mimotopes.
European journal of immunology 2010;40(7):1950-62.
2010: Narasimhan J Venkatachari; Leah A Walker; Oznur Tastan; Thien Le; Timothy M Dempsey; Yaming Li; Naveena Yanamala; Alagarsamy Srinivasan; Judith Klein-Seetharaman; Ronald Montelaro; Velpandi Ayyavoo
Human immunodeficiency virus type 1 Vpr: oligomerization is an essential feature for its incorporation into virus particles.
Virology journal 2010;7():119.
2009: Biswanath Majumder; Narasimhan J Venkatachari; Alagarsamy Srinivasan; Velpandi Ayyavoo
HIV-1 mediated immune pathogenesis: spotlight on the role of viral protein R (Vpr).
Current HIV research 2009;7(2):169-77.
2009: Narasimhan J Venkatachari; Sean Alber; simon simon watkins; Velpandi Ayyavoo
HIV-1 infection of DC: evidence for the acquisition of virus particles from infected T cells by antigen uptake mechanism.
PloS one 2009;4(10):e7470.
2008: Biswanath Majumder; Narasimhan J Venkatachari; Shaylee O'Leary; Velpandi Ayyavoo
Infection with Vpr-positive human immunodeficiency virus type 1 impairs NK cell function indirectly through cytokine dysregulation of infected target cells.
Journal of virology 2008;82(14):7189-200.
2008: Narasimhan J Venkatachari; William G Buchanan; Velpandi Ayyavoo
Human immunodeficiency virus (HIV-1) infection selectively downregulates PD-1 expression in infected cells and protects the cells from early apoptosis in vitro and in vivo.
Virology 2008;376(1):140-53.
2008: Alagarsamy Srinivasan; Velpandi Ayyavoo; Sundarasamy Mahalingam; Aarthi Kannan; Anne Boyd; Debduti Datta; Vaniambadi S Kalyanaraman; Anthony Cristillo; Ronald G Collman; Nelly Morellet; Bassel E Sawaya; Ramachandran Murali
A comprehensive analysis of the naturally occurring polymorphisms in HIV-1 Vpr: potential impact on CTL epitopes.
Virology journal 2008;5():99.
2007: Ronald P Trible; Lori Emert-Sedlak; Thomas E Wales; Velpandi Ayyavoo; John R Engen; Thomas E Smithgall
Allosteric loss-of-function mutations in HIV-1 Nef from a long-term non-progressor.
Journal of molecular biology 2007;374(1):121-9.
2007: Biswanath Majumder; Narasimhan J Venkatachari; Elizabeth A Schafer; Michelle L Janket; Velpandi Ayyavoo
Dendritic cells infected with vpr-positive human immunodeficiency virus type 1 induce CD8+ T-cell apoptosis via upregulation of tumor necrosis factor alpha.
Journal of virology 2007;81(14):7388-99.
2007: Keri L Schaubert; David A Price; Nicole Frahm; Jinzhu Li; Hwee Ng; Aviva Joseph; Elyse Paul; Biswanath Majumder; Velpandi Ayyavoo; Emma Gostick; Sharon Adams; Francesco M Marincola; Andrew K Sewell; Marcus Altfeld; Jason M Brenchley; Daniel C Douek; Otto O Yang; Christian Brander; Harris Goldstein; June Kan-Mitchell
Availability of a diversely avid CD8+ T cell repertoire specific for the subdominant HLA-A2-restricted HIV-1 Gag p2419-27 epitope.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(12):7756-66.
2007: Michelle L Janket; Jeremy Dericco; LuAnn Borowski; Velpandi Ayyavoo
Human immunodeficiency virus (HIV-1) Vpr induced downregulation of NHE1 induces alteration in intracellular pH and loss of ERM complex in target cells.
Virus research 2007;126(1-2):76-85.
2007: Narasimhan J Venkatachari; Biswanath Majumder; Velpandi Ayyavoo
Human immunodeficiency virus (HIV) type 1 Vpr induces differential regulation of T cell costimulatory molecules: direct effect of Vpr on T cell activation and immune function.
Virology 2007;358(2):347-56.
2006: Elizabeth A Schafer; Narasimhan J Venkatachari; Velpandi Ayyavoo
Antiviral effects of mifepristone on human immunodeficiency virus type-1 (HIV-1): targeting Vpr and its cellular partner, the glucocorticoid receptor (GR).
Antiviral research 2006;72(3):224-32.
2006: Jianqi Cui; Tungaturthi Parithosh; Velpandi Ayyavoo; Mohammad Ghafouri; Hiroyoshi Ariga; Kamel Khalili; Alagarsamy Srinivasan; Shohreh Amini; Bassel E Sawaya
The role of Vpr in the regulation of HIV-1 gene expression.
Cell cycle (Georgetown, Tex.) 2006;5(22):2626-38.
2006: Elizabeth D A Wheeler; Cristian L Achim; Velpandi Ayyavoo
Immunodetection of human immunodeficiency virus type 1 (HIV-1) Vpr in brain tissue of HIV-1 encephalitic patients.
Journal of neurovirology 2006;12(3):200-10.
2005: Melissa C Miles; Michelle L Janket; Elizabeth D A Wheeler; Ansuman Chattopadhyay; Biswanath Majumder; Jeremy Dericco; Elizabeth A Schafer; Velpandi Ayyavoo
Molecular and functional characterization of a novel splice variant of ANKHD1 that lacks the KH domain and its role in cell survival and apoptosis.
The FEBS journal 2005;272(16):4091-102.
2005: Biswanath Majumder; Michelle L Janket; Elizabeth A Schafer; Keri Schaubert; Xiao-Li Huang; June Kan-Mitchell; Charles Rinaldo; Velpandi Ayyavoo
Human immunodeficiency virus type 1 Vpr impairs dendritic cell maturation and T-cell activation: implications for viral immune escape.
Journal of virology 2005;79(13):7990-8003.
2004: Dineshkumar Thotala; Elizabeth A Schafer; Tungaturthi Parithosh; Biswanath Majumder; Michelle L Janket; Marc Wagner; Alagarsamy Srinivasan; simon simon watkins; Velpandi Ayyavoo
Structure-functional analysis of human immunodeficiency virus type 1 (HIV-1) Vpr: role of leucine residues on Vpr-mediated transactivation and virus replication.
Virology 2004;328(1):89-100.
2004: Tungaturthi Parithosh; Bassel E Sawaya; Velpandi Ayyavoo; Ramachandran Murali; Alagarsamy Srinivasan
HIV-1 Vpr: genetic diversity and functional features from the perspective of structure.
DNA and cell biology 2004;23(4):207-22.
2004: Michelle L Janket; Pachiappan Manickam; Biswanath Majumder; Dineshkumar Thotala; Marc Wagner; Elizabeth A Schafer; Ronald G Collman; Alagarsamy Srinivasan; Velpandi Ayyavoo
Differential regulation of host cellular genes by HIV-1 viral protein R (Vpr): cDNA microarray analysis using isogenic virus.
Biochemical and biophysical research communications 2004;314(4):1126-32.
2003: Biswanath Majumder; Benjamin Gray; Sean McBurney; Todd M Schaefer; Tzvete Dentchev; Sundarasamy Mahalingam; Todd A Reinhart; Velpandi Ayyavoo
Attenuated nef DNA vaccine construct induces cellular immune response: role in HIV-1 multiprotein vaccine.
Immunology letters 2003;89(2-3):207-14.
2003: Michael G Agadjanyan; Michael Chattergoon; Mark J Holterman; Behjatolah Monzavi-Karbassi; J Joseph Kim; Tzvete Dentchev; Darren Wilson; Velpandi Ayyavoo; Luis J Montaner; Thomas Kieber-Emmons; Rafick-Pierre Sekaly; David B Weiner
Costimulatory molecule immune enhancement in a plasmid vaccine model is regulated in part through the Ig constant-like domain of CD80/86.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(8):4311-9.
2003: Tungaturthi Parithosh; Bassel E Sawaya; Satya P Singh; Brian Tomkowicz; Velpandi Ayyavoo; Kamel Khalili; Ronald G Collman; Shohreh Amini; Alagarsamy Srinivasan
Role of HIV-1 Vpr in AIDS pathogenesis: relevance and implications of intravirion, intracellular and free Vpr.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2003;57(1):20-4.
2002: Karuppiah Muthumani; Mark Bagarazzi; D Conway; Daniel S Hwang; Velpandi Ayyavoo; Donghui Zhang; Kelledy Manson; Jong Kim; Jean Boyer; David B Weiner
Inclusion of Vpr accessory gene in a plasmid vaccine cocktail markedly reduces Nef vaccine effectiveness in vivo resulting in CD4 cell loss and increased viral loads in rhesus macaques.
Journal of medical primatology 2002;31(4-5):179-85.
2002: Karuppiah Muthumani; Sagar Kudchodkar; Donghui Zhang; Mark Bagarazzi; Joseph J Kim; Jean D Boyer; Velpandi Ayyavoo; George Pavlakis; David B Weiner
Issues for improving multiplasmid DNA vaccines for HIV-1.
Vaccine 2002;20(15):1999-2003.
2002: Velpandi Ayyavoo; Karuppiah Muthumani; Sagar Kudchodkar; Donghui Zhang; P Ramanathan; Nathanael S Dayes; J J Kim; Jeong-Im Sin; Luis J Montaner; David B Weiner
HIV-1 viral protein R compromises cellular immune function in vivo.
International immunology 2002;14(1):13-22.
2001: R Vanitharani; Sundarasamy Mahalingam; Y Rafaeli; S P Singh; Alagarsamy Srinivasan; David B Weiner; Velpandi Ayyavoo
HIV-1 Vpr transactivates LTR-directed expression through sequences present within -278 to -176 and increases virus replication in vitro.
Virology 2001;289(2):334-42.
2001: Mathura P Ramanathan; Velpandi Ayyavoo; David B Weiner
Choice of expression vector alters the localization of a human cellular protein.
DNA and cell biology 2001;20(2):101-5.
2000: Karuppiah Muthumani; Sagar Kudchodkar; Emmanouil Papasavvas; Luis J Montaner; David B Weiner; Velpandi Ayyavoo
HIV-1 Vpr regulates expression of beta chemokines in human primary lymphocytes and macrophages.
Journal of leukocyte biology 2000;68(3):366-72.
2000: Michael Chattergoon; Joseph J Kim; J S Yang; Tara M Robinson; D J Lee; Tzvete Dentchev; DM Wilson; Velpandi Ayyavoo; David B Weiner
Targeted antigen delivery to antigen-presenting cells including dendritic cells by engineered Fas-mediated apoptosis.
Nature biotechnology 2000;18(9):974-9.
2000: Karuppiah Muthumani; Luis J Montaner; Velpandi Ayyavoo; David B Weiner
Vpr-GFP virion particle identifies HIV-infected targets and preserves HIV-1Vpr function in macrophages and T-cells.
DNA and cell biology 2000;19(3):179-88.
2000: Velpandi Ayyavoo; Sagar Kudchodkar; Mathura P Ramanathan; P Le; Karuppiah Muthumani; N M Megalai; Tzvete Dentchev; L Santiago-Barrios; Conjeevaram Mrinalini; David B Weiner
Immunogenicity of a novel DNA vaccine cassette expressing multiple human immunodeficiency virus (HIV-1) accessory genes.
AIDS (London, England) 2000;14(1):1-9.
2000: Jeong-Im Sin; J Kim; Michael Chattergoon; Velpandi Ayyavoo; D McCallus; Kenneth Ugen; Jean D Boyer; David B Weiner
Engineering of DNA vaccines using molecular adjuvant plasmids.
Developments in biologicals 2000;104():187-98.
1999: Jeong-Im Sin; Velpandi Ayyavoo; Jean Boyer; J Kim; Richard B Ciccarelli; David B Weiner
Protective immune correlates can segregate by vaccine type in a murine herpes model system.
International immunology 1999;11(11):1763-73.
1998: Velpandi Ayyavoo; T Nagashunmugam; M T Phung; C Buckner; S Kudckodkar; P Le; P J Reddy; L Santiago; M Patel; L Tea; David B Weiner
Construction of attenuated HIV-1 accessory gene immunization cassettes.
Vaccine 1998;16(19):1872-9.
1998: Sundarasamy Mahalingam; Velpandi Ayyavoo; M Patel; Thomas Kieber-Emmons; Gary D Kao; Ruth J Muschel; David B Weiner
HIV-1 Vpr interacts with a human 34-kDa mov34 homologue, a cellular factor linked to the G2/M phase transition of the mammalian cell cycle.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(7):3419-24.
1998: Mark Bagarazzi; Jean D Boyer; Velpandi Ayyavoo; David B Weiner
Nucleic acid-based vaccines as an approach to immunization against human immunodeficiency virus type-1.
Current topics in microbiology and immunology 1998;226():107-43.
1997: Velpandi Ayyavoo; T Nagashunmugam; Jean Boyer; Sundarasamy Mahalingam; L S Fernandes; P Le; J Lin; C Nguyen; M Chattargoon; J J Goedert; Harvey Friedman; David B Weiner
Development of genetic vaccines for pathogenic genes: construction of attenuated vif DNA immunization cassettes.
AIDS (London, England) 1997;11(12):1433-44.
1997: Velpandi Ayyavoo; A Mahboubi; Sundarasamy Mahalingam; R Ramalingam; Sagar Kudchodkar; William V Williams; Douglas R Green; David B Weiner
HIV-1 Vpr suppresses immune activation and apoptosis through regulation of nuclear factor kappa B.
Nature medicine 1997;3(10):1117-23.
1997: Sundarasamy Mahalingam; Velpandi Ayyavoo; M Patel; Thomas Kieber-Emmons; David B Weiner
Nuclear import, virion incorporation, and cell cycle arrest/differentiation are mediated by distinct functional domains of human immunodeficiency virus type 1 Vpr.
Journal of virology 1997;71(9):6339-47.
1997: Velpandi Ayyavoo; Sundarasamy Mahalingam; Y Rafaeli; Sagar Kudchodkar; D Chang; T Nagashunmugam; William V Williams; David B Weiner
HIV-1 viral protein R (Vpr) regulates viral replication and cellular proliferation in T cells and monocytoid cells in vitro.
Journal of leukocyte biology 1997;62(1):93-9.
1997: Joseph J Kim; Velpandi Ayyavoo; Mark Bagarazzi; Michael Chattergoon; Jean D Boyer; Bin Wang; David B Weiner
Development of a multicomponent candidate vaccine for HIV-1.
Vaccine 1997;15(8):879-83.
1997: Sundarasamy Mahalingam; B MacDonald; Kenneth Ugen; Velpandi Ayyavoo; Michael G Agadjanyan; William V Williams; David B Weiner
In vitro and in vivo tumor growth suppression by HIV-1 Vpr.
DNA and cell biology 1997;16(2):137-43.
1997: Joseph J Kim; Velpandi Ayyavoo; Mark Bagarazzi; Michael Chattergoon; Kesen Dang; Bin Wang; Jean D Boyer; David B Weiner
In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(2):816-26.
1997: Velpandi Ayyavoo; Y Rafaeli; T Nagashunmugam; S Mahalingham; M T Phung; A Hamam; William V Williams; David B Weiner
HIV-1 viral protein R (Vpr) as a regulator of the target cell.
Psychoneuroendocrinology 1997;22 Suppl 1():S41-9.
1996: Velpandi Ayyavoo; Kenneth Ugen; L S Fernandes; J J Goedert; Arye Rubinstein; William V Williams; David B Weiner
Analysis of genetic heterogeneity, antigenicity, and biological characteristics of HIV-1 in a maternal transmitter and nontransmitter patient pair.
DNA and cell biology 1996;15(7):571-80.
1994: Kenneth Ugen; Bin Wang; Velpandi Ayyavoo; Michael G Agadjanyan; Jean Boyer; F Li; Sagar Kudchodkar; J Lin; M Merva; L Fernandes
DNA inoculation as a novel vaccination method against human retroviruses with rheumatic disease associations.
Immunologic research 1994;13(2-3):154-62.