FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Michael Jarvis

Research Profile

Living Beings

Chemicals & Drugs

Disorders

Concepts & Ideas

Co-author Network

Publications

TOP 3
T R Miller; J B Wetter; Michael F Jarvis; R S Bitner
Spinal microglial activation in rat models of neuropathic and osteoarthritic pain: an autoradiographic study using [3H]PK11195.
Xu-Feng Zhang; Michael F Jarvis; Steve McGaraughty; Carol S Surowy; Betty Yao; Di Zhang; Torben R Neelands
Development and validation of a medium-throughput electrophysiological assay for KCNQ2/3 channel openers using QPatch HT.
Andrew M Swensen; Timothy A Vortherms; Michael F Jarvis; Lance Lee; Tao Li; Wende Niforatos; Richard J Perner; Michael R Schrimpf; Victoria E Scott; Steve McGaraughty
An automated electrophysiological assay for differentiating Ca(v)2.2 inhibitors based on state dependence and kinetics.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Michael Jarvis (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: T R Miller; J B Wetter; Michael F Jarvis; R S Bitner
Spinal microglial activation in rat models of neuropathic and osteoarthritic pain: an autoradiographic study using [3H]PK11195.
European journal of pain (London, England) 2013;17(5):692-703.
2013: Xu-Feng Zhang; Michael F Jarvis; Steve McGaraughty; Carol S Surowy; Betty Yao; Di Zhang; Torben R Neelands
Development and validation of a medium-throughput electrophysiological assay for KCNQ2/3 channel openers using QPatch HT.
Assay and drug development technologies 2013;11(1):17-24.
2012: Andrew M Swensen; Timothy A Vortherms; Michael F Jarvis; Lance Lee; Tao Li; Wende Niforatos; Richard J Perner; Michael R Schrimpf; Victoria E Scott; Steve McGaraughty
An automated electrophysiological assay for differentiating Ca(v)2.2 inhibitors based on state dependence and kinetics.
Assay and drug development technologies 2012;10(6):542-50.
2012: Michael F Jarvis
Cytochrome P450 mediated linoleic acid metabolism in peripheral inflammatory nociception.
Pain 2012;153(10):1987-8.
2012: Jun Xu; Jill-Desiree Brederson; Katharine L Chu; Michael F Jarvis; Steve McGaraughty
Spontaneous firing and evoked responses of spinal nociceptive neurons are attenuated by blockade of P2X3 and P2X2/3 receptors in inflamed rats.
Journal of neuroscience research 2012;90(8):1597-606.
2012: Xenia Beebe; Janel M Boyce-Rustay; Daria Darczak; Diana L Donnelly-Roberts; Pamela Franklin; Erica Gomez; Rodger F Henry; Richard Janis; Michael F Jarvis; Karen Kage; Kennan Marsh; Ivan Milicic; Marian T Namovic; Wende Niforatos; Gricelda Simler; Andrew O Stewart; Carol S Surowy; Andrew Swensen; Timothy A Vortherms; Jill M Wetter; Chengmin Zhong; Chang Z Zhu; Scott Baker; Victoria E Scott
Synthesis and SAR of 4-aminocyclopentapyrrolidines as N-type Ca²⁺ channel blockers with analgesic activity.
Bioorganic & medicinal chemistry 2012;20(13):4128-39.
2012: Marian T Namovic; Michael F Jarvis; Diana L Donnelly-Roberts
High throughput functional assays for P2X receptors.
Current protocols in pharmacology / editorial board, S.J. Enna (editor-in-chief) ... [et al.] 2012;Chapter 9():Unit 9.15..
2012: Jill-Desiree Brederson; Brian S Brown; Katharine L Chu; Michael F Jarvis; Philip R Kym; Regina M Reilly; Steve McGaraughty
TRPV1 antagonist, A-889425, inhibits mechanotransmission in a subclass of rat primary afferent neurons following peripheral inflammation.
Synapse (New York, N.Y.) 2012;66(3):187-95.
2012: George A Doherty; Michael F Jarvis; Helmut Mack; Kennan Marsh; Victoria E Scott; Timothy A Vortherms; Jill M Wetter; Pramila Bhatia; Andrew O Stewart
Discovery of diphenyl lactam derivatives as N-type calcium channel blockers.
Bioorganic & medicinal chemistry letters 2012;22(4):1716-8.
2012: Rebecca J Gum; Brian Wakefield; Michael F Jarvis
P2X receptor antagonists for pain management: examination of binding and physicochemical properties.
Purinergic signalling 2012;8(Suppl 1):41-56.
2011: Jill-Desiree Brederson; Prisca Honore; Michael F Jarvis; Carol S Surowy
Fibromyalgia: mechanisms, current treatment and animal models.
Current pharmaceutical biotechnology 2011;12(10):1613-26.
2011: Timothy A Vortherms; Di Zhang; Carol S Surowy; Andrew M Swensen; Rama Thimmapaya; C Brent Putman; Diana L Donnelly-Roberts; Richard S Janis; Michael F Jarvis; James T Limberis; Ruth L Martin; Marian T Namovic; Torben R Neelands; Wende Niforatos; Victoria E Scott
Comparative analysis of inactivated-state block of N-type (Ca(v)2.2) calcium channels.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2011;60(7):683-93.
2011: Arturo Perez-Medrano; Diana L Donnelly-Roberts; Alan S Florjancic; Derek W Nelson; Tongmei Li; Marian T Namovic; Sridhar Peddi; Connie R Faltynek; Michael F Jarvis; William A Carroll
Synthesis and in vitro activity of N-benzyl-1-(2,3-dichlorophenyl)-1H-tetrazol-5-amine P2X(7) antagonists.
Bioorganic & medicinal chemistry letters 2011;21(11):3297-300.
2011: Katharine L Chu; Prasant Chandran; Shailen K Joshi; Michael F Jarvis; Philip R Kym; Steve McGaraughty
TRPV1-related modulation of spinal neuronal activity and behavior in a rat model of osteoarthritic pain.
Brain research 2011;1369():158-66.
2011: Younglim Lee; Madhavi Pai; Denise Wilcox; Jill-Desiree Brederson; Gin C Hsieh; Michael F Jarvis; Robert S Bitner
Monosodium iodoacetate-induced joint pain is associated with increased phosphorylation of mitogen activated protein kinases in the rat spinal cord.
Molecular pain 2011;7():39.
2010: Marc J C Scanio; Lei Shi; Irene Drizin; Robert J Gregg; Robert N Atkinson; James B Thomas; Matthew S Johnson; Mark L Chapman; Dong Liu; Michael J Krambis; Yi Liu; Char-Chang Shieh; Xufeng Zhang; Gricelda H Simler; Shailen Joshi; Prisca Honore; Kennan Marsh; Alison Knox; Stephen Werness; Brett Antonio; Douglas S Krafte; Michael F Jarvis; Connie R Faltynek; Brian E Marron; Michael E Kort
Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Na(v)1.8 sodium channel with efficacy in a model of neuropathic pain.
Bioorganic & medicinal chemistry 2010;18(22):7816-25.
2010: Michael E Kort; Robert N Atkinson; James B Thomas; Irene Drizin; Matthew S Johnson; Matthew A Secrest; Robert J Gregg; Marc J C Scanio; Lei Shi; Ahmed H Hakeem; Mark A Matulenko; Mark L Chapman; Michael J Krambis; Dong Liu; Char-Chang Shieh; XuFeng Zhang; Gricelda Simler; Joe Mikusa; Chengmin Zhong; Shailen Joshi; Prisca Honore; Rosemarie Roeloffs; Stephen Werness; Brett Antonio; Kennan Marsh; Connie R Faltynek; Douglas S Krafte; Michael F Jarvis; Brian E Marron
Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives.
Bioorganic & medicinal chemistry letters 2010;20(22):6812-5.
2010: Xu-Feng Zhang; Char-Chang Shieh; Mark L Chapman; Mark A Matulenko; Ahmed H Hakeem; Robert N Atkinson; Michael E Kort; Brian E Marron; Shailen Joshi; Prisca Honore; Connie R Faltynek; Douglas S Krafte; Michael F Jarvis
A-887826 is a structurally novel, potent and voltage-dependent Na(v)1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats.
Neuropharmacology 2010;59(3):201-7.
2010: Janel M Boyce-Rustay; Prisca Honore; Michael F Jarvis
Animal models of acute and chronic inflammatory and nociceptive pain.
Methods in molecular biology (Clifton, N.J.) 2010;617():41-55.
2010: Michael F Jarvis
The neural-glial purinergic receptor ensemble in chronic pain states.
Trends in neurosciences 2010;33(1):48-57.
2009: Prisca Honore; Diana L Donnelly-Roberts; Marian T Namovic; Chengmin Zhong; Carrie Wade; Prasant Chandran; Chang Zhu; William Carroll; Arturo Perez-Medrano; Yoichiro Iwakura; Michael F Jarvis
The antihyperalgesic activity of a selective P2X7 receptor antagonist, A-839977, is lost in IL-1alphabeta knockout mice.
Behavioural brain research 2009;204(1):77-81.
2009: Diana L Donnelly-Roberts; Marian T Namovic; Ping Han; Michael F Jarvis
Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors.
British journal of pharmacology 2009;157(7):1203-14.
2009: Arturo Perez-Medrano; Diana L Donnelly-Roberts; Prisca Honore; Gin C Hsieh; Marian T Namovic; Sridhar Peddi; Qi Shuai; Ying Wang; Connie R Faltynek; Michael F Jarvis; William A Carroll
Discovery and biological evaluation of novel cyanoguanidine P2X(7) antagonists with analgesic activity in a rat model of neuropathic pain.
Journal of medicinal chemistry 2009;52(10):3366-76.
2009: Ana M Basso; Natalie A Bratcher; Richard R Harris; Michael F Jarvis; Michael W Decker; Lynne E Rueter
Behavioral profile of P2X7 receptor knockout mice in animal models of depression and anxiety: relevance for neuropsychiatric disorders.
Behavioural brain research 2009;198(1):83-90.
2009: Prisca Honore; Prasant Chandran; Gricelda Hernandez; Donna M Gauvin; Joe Mikusa; Chengmin Zhong; Shailen K Joshi; Joseph R Ghilardi; Molly A Sevcik; Ryan M Fryer; Jason A Segreti; Patricia N Banfor; Kennan Marsh; Torben R Neelands; Erol Bayburt; Jerome F Daanen; Arthur Gomtsyan; Abel Lee; Michael E Kort; Regina M Reilly; Carol S Surowy; Philip R Kym; Patrick W Mantyh; James P Sullivan; Michael F Jarvis; Connie R Faltynek
Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia.
Pain 2009;142(1-2):27-35.
2009: S K Joshi; Prisca Honore; Gricelda Hernandez; Robert Schmidt; Arthur Gomtsyan; Marc Scanio; Michael Kort; Michael F Jarvis
Additive antinociceptive effects of the selective Nav1.8 blocker A-803467 and selective TRPV1 antagonists in rat inflammatory and neuropathic pain models.
The journal of pain : official journal of the American Pain Society 2009;10(3):306-15.
2009: William A Carroll; Diana L Donnelly-Roberts; Michael F Jarvis
Selective P2X(7) receptor antagonists for chronic inflammation and pain.
Purinergic signalling 2009;5(1):63-73.
2009: Michael F Jarvis; Janel M Boyce-Rustay
Neuropathic pain: models and mechanisms.
Current pharmaceutical design 2009;15(15):1711-6.
2009: Michael F Jarvis; Baljit S Khakh
ATP-gated P2X cation-channels.
Neuropharmacology 2009;56(1):208-15.
2009: Diana L Donnelly-Roberts; Marian T Namovic; Bruce W Surber; Srirajan X Vaidyanathan; Arturo Perez-Medrano; Ying Wang; William A Carroll; Michael F Jarvis
[3H]A-804598 ([3H]2-cyano-1-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine) is a novel, potent, and selective antagonist radioligand for P2X7 receptors.
Neuropharmacology 2009;56(1):223-9.
2008: Steve McGaraughty; Katharine L Chu; Brian S Brown; Chang Z Zhu; Chengmin Zhong; Shailen K Joshi; Prisca Honore; Connie R Faltynek; Michael F Jarvis
Contributions of central and peripheral TRPV1 receptors to mechanically evoked and spontaneous firing of spinal neurons in inflamed rats.
Journal of neurophysiology 2008;100(6):3158-66.
2008: Brian S Brown; Ryan G Keddy; Guo Zhu Zheng; Robert G Schmidt; John R Koenig; Heath A McDonald; Bruce R Bianchi; Prisca Honore; Michael F Jarvis; Carol S Surowy; James S Polakowski; Kennan Marsh; Connie R Faltynek; Abel Lee
Tetrahydropyridine-4-carboxamides as novel, potent transient receptor potential vanilloid 1 (TRPV1) antagonists.
Bioorganic & medicinal chemistry 2008;16(18):8516-25.
2008: Carol S Surowy; Torben R Neelands; Bruce R Bianchi; Steve McGaraughty; Rachid El Kouhen; Ping Han; Katharine L Chu; Heath A McDonald; Melissa Vos; Wende Niforatos; Erol K Bayburt; Arthur Gomtsyan; Abel Lee; Prisca Honore; James P Sullivan; Michael F Jarvis; Connie R Faltynek
(R)-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea (ABT-102) blocks polymodal activation of transient receptor potential vanilloid 1 receptors in vitro and heat-evoked firing of spinal dorsal horn neurons in vivo.
The Journal of pharmacology and experimental therapeutics 2008;326(3):879-88.
2008: Jill-Desiree Brederson; Michael F Jarvis
Homomeric and heteromeric P2X3 receptors in peripheral sensory neurons.
Current opinion in investigational drugs (London, England : 2000) 2008;9(7):716-25.
2008: Irene Drizin; Robert J Gregg; Marc J C Scanio; Lei Shi; Michael F Gross; Robert N Atkinson; James B Thomas; Matthew S Johnson; William A Carroll; Brian E Marron; Mark L Chapman; Dong Liu; Michael J Krambis; Char-Chang Shieh; XuFeng Zhang; Gricelda Hernandez; Donna M Gauvin; Joe Mikusa; Chang Z Zhu; Shailen Joshi; Prisca Honore; Kennan Marsh; Rosemarie Roeloffs; Stephen Werness; Douglas S Krafte; Michael F Jarvis; Connie R Faltynek; Michael E Kort
Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic pain.
Bioorganic & medicinal chemistry 2008;16(12):6379-86.
2008: Derek W Nelson; Kathy A Sarris; Douglas Kalvin; Marian T Namovic; George Grayson; Diana L Donnelly-Roberts; Richard Harris; Prisca Honore; Michael F Jarvis; Connie R Faltynek; William A Carroll
Structure-activity relationship studies on N'-aryl carbohydrazide P2X7 antagonists.
Journal of medicinal chemistry 2008;51(10):3030-4.
2008: Alan S Florjancic; Sridhar Peddi; Arturo Perez-Medrano; Biqin Li; Marian T Namovic; George Grayson; Diana L Donnelly-Roberts; Michael F Jarvis; William A Carroll
Synthesis and in vitro activity of 1-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-1H-1,2,4-triazol-5-amine and 4-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-4H-1,2,4-triazol-3-amine P2X7 antagonists.
Bioorganic & medicinal chemistry letters 2008;18(6):2089-92.
2008: Michael J Morytko; Patrick Betschmann; Kevin Woller; Anna Ericsson; Haipeng Chen; Diana L Donnelly-Roberts; Marian T Namovic; Michael F Jarvis; William A Carroll; Paul Rafferty
Synthesis and in vitro activity of N'-cyano-4-(2-phenylacetyl)-N-o-tolylpiperazine-1-carboximidamide P2X7 antagonists.
Bioorganic & medicinal chemistry letters 2008;18(6):2093-6.
2008: Xenia Beebe; Daria Darczak; Rachel Davis-Taber; Marie E Uchic; Victoria E Scott; Michael F Jarvis; Andrew O Stewart
Discovery and SAR of hydrazide antagonists of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor type 1 (PAC1-R).
Bioorganic & medicinal chemistry letters 2008;18(6):2162-6.
2008: Steve McGaraughty; Katharine L Chu; Marc J C Scanio; Michael E Kort; Connie R Faltynek; Michael F Jarvis
A selective Nav1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats.
The Journal of pharmacology and experimental therapeutics 2008;324(3):1204-11.
2008: Arthur Gomtsyan; Erol K Bayburt; Robert G Schmidt; Carol S Surowy; Prisca Honore; Kennan Marsh; Steven M Hannick; Heath A McDonald; Jill M Wetter; James P Sullivan; Michael F Jarvis; Connie R Faltynek; Abel Lee
Identification of (R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)urea (ABT-102) as a potent TRPV1 antagonist for pain management.
Journal of medicinal chemistry 2008;51(3):392-5.
2008: Michael E Kort; Irene Drizin; Robert J Gregg; Marc J C Scanio; Lei Shi; Michael F Gross; Robert N Atkinson; Matthew S Johnson; Gregory J Pacofsky; James B Thomas; William A Carroll; Michael J Krambis; Dong Liu; Char-Chang Shieh; Xufeng Zhang; Gricelda Hernandez; Joe Mikusa; Chengmin Zhong; Shailen Joshi; Prisca Honore; Rosemarie Roeloffs; Kennan Marsh; Bernard P Murray; Jinrong Liu; Stephen Werness; Connie R Faltynek; Douglas S Krafte; Michael F Jarvis; Mark L Chapman; Brian E Marron
Discovery and biological evaluation of 5-aryl-2-furfuramides, potent and selective blockers of the Nav1.8 sodium channel with efficacy in models of neuropathic and inflammatory pain.
Journal of medicinal chemistry 2008;51(3):407-16.
2008: Diana L Donnelly-Roberts; Steve McGaraughty; Char-Chang Shieh; Prisca Honore; Michael F Jarvis
Painful purinergic receptors.
The Journal of pharmacology and experimental therapeutics 2008;324(2):409-15.
2007: Bruce R Bianchi; Rachid El Kouhen; Torben R Neelands; Abel Lee; Arthur Gomtsyan; Shirish N Raja; Sriajan N Vaidyanathan; Bruce W Surber; Heath A McDonald; Carol S Surowy; Connie R Faltynek; Robert B Moreland; Michael F Jarvis; Pamela S Puttfarcken
[3H]A-778317 [1-((R)-5-tert-butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a novel, stereoselective, high-affinity antagonist is a useful radioligand for the human transient receptor potential vanilloid-1 (TRPV1) receptor.
The Journal of pharmacology and experimental therapeutics 2007;323(1):285-93.
2007: Richard J Perner; Stanley Didomenico; John R Koenig; Arthur Gomtsyan; Erol K Bayburt; Robert G Schmidt; Irene Drizin; Guo Zhu Zheng; Sean C Turner; Tammie K Jinkerson; Brian S Brown; Ryan G Keddy; Kurill Lukin; Heath A McDonald; Prisca Honore; Joe Mikusa; Kennan Marsh; Jill M Wetter; Karen St George; Michael F Jarvis; Connie R Faltynek; Abel Lee
In vitro structure-activity relationship and in vivo characterization of 1-(aryl)-3-(4-(amino)benzyl)urea transient receptor potential vanilloid 1 antagonists.
Journal of medicinal chemistry 2007;50(15):3651-60.
2007: William A Carroll; Douglas Kalvin; Arturo Perez-Medrano; Alan S Florjancic; Ying Wang; Diana L Donnelly-Roberts; Marian T Namovic; George Grayson; Prisca Honoré; Michael F Jarvis
Novel and potent 3-(2,3-dichlorophenyl)-4-(benzyl)-4H-1,2,4-triazole P2X7 antagonists.
Bioorganic & medicinal chemistry letters 2007;17(14):4044-8.
2007: Diana L Donnelly-Roberts; Michael F Jarvis
Discovery of P2X7 receptor-selective antagonists offers new insights into P2X7 receptor function and indicates a role in chronic pain states.
British journal of pharmacology 2007;151(5):571-9.
2007: Steve McGaraughty; Katharine L Chu; Marian T Namovic; Diana L Donnelly-Roberts; Richard R Harris; Xu-Feng Zhang; Char-Chang Shieh; Carol T Wismer; Chang Z Zhu; Donna M Gauvin; Adebola Fabiyi; Prisca Honore; Robert J Gregg; Michael E Kort; D W Nelson; William A Carroll; Kennan Marsh; Connie R Faltynek; Michael F Jarvis
P2X7-related modulation of pathological nociception in rats.
Neuroscience 2007;146(4):1817-28.
2007: Ping Han; Heath A McDonald; Bruce R Bianchi; Rachid El Kouhen; Melissa H Vos; Michael F Jarvis; Connie R Faltynek; Robert B Moreland
Capsaicin causes protein synthesis inhibition and microtubule disassembly through TRPV1 activities both on the plasma membrane and intracellular membranes.
Biochemical pharmacology 2007;73(10):1635-45.
2007: Douglas S Krafte; Mark Chapman; Brian Marron; Robert Atkinson; Yi Liu; Fei Ye; Mark Curran; Michael Kort; Michael F Jarvis
Block of Nav1.8 by small molecules.
Channels (Austin, Tex.) 2007;1(3):152-3.
2007: Mark A Matulenko; Ernest S Paight; Robin R Frey; Arthur Gomtsyan; Stanley Didomenico; Meiqun Jiang; Abel Lee; Andrew O Stewart; Haixia Yu; Kathy L Kohlhaas; Easaw Alexander; Steve McGaraughty; Joe Mikusa; Kennan Marsh; Steven W Muchmore; Clarissa L Jakob; Elizabeth A Kowaluk; Michael F Jarvis; Shripad S Bhagwat
4-amino-5-aryl-6-arylethynylpyrimidines: structure-activity relationships of non-nucleoside adenosine kinase inhibitors.
Bioorganic & medicinal chemistry 2007;15(4):1586-605.
2006: Prisca Honore; Diana L Donnelly-Roberts; Marian T Namovic; Gin C Hsieh; Chang Z Zhu; Joe Mikusa; Gricelda Hernandez; Chengmin Zhong; Donna M Gauvin; Prasant Chandran; Richard Harris; Arturo Perez Medrano; William Carroll; Kennan Marsh; James P Sullivan; Connie R Faltynek; Michael F Jarvis
A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat.
The Journal of pharmacology and experimental therapeutics 2006;319(3):1376-85.
2006: Steven W Muchmore; Richard A Smith; Andrew O Stewart; Marlon D Cowart; Arthur Gomtsyan; Mark A Matulenko; Haixia Yu; Jean M Severin; Shripad S Bhagwat; Abel Lee; Elizabeth A Kowaluk; Michael F Jarvis; Clarissa L Jakob
Crystal structures of human adenosine kinase inhibitor complexes reveal two distinct binding modes.
Journal of medicinal chemistry 2006;49(23):6726-31.
2006: James J Lynch; Prisca Honore; David J Anderson; William H Bunnelle; Kathleen H Mortell; Chengmin Zhong; Carrie L Wade; Chang Z Zhu; Hongyu Xu; Kennan Marsh; Abel Lee; Michael F Jarvis; Murali Gopalakrishnan
(L)-Phenylglycine, but not necessarily other alpha2delta subunit voltage-gated calcium channel ligands, attenuates neuropathic pain in rats.
Pain 2006;125(1-2):136-42.
2006: Char-Chang Shieh; Michael F Jarvis; Abel Lee; Richard J Perner
P2X receptor ligands and pain.
Expert opinion on therapeutic patents 2006;16(8):1113-27.
2006: Irene Drizin; Arthur Gomtsyan; Erol K Bayburt; Robert G Schmidt; Guo Zhu Zheng; Richard J Perner; Stanley Didomenico; John R Koenig; Sean C Turner; Tammie K Jinkerson; Brian S Brown; Ryan G Keddy; Heath A McDonald; Prisca Honore; Carol T Wismer; Kennan Marsh; Jill M Wetter; James S Polakowski; Jason A Segreti; Michael F Jarvis; Connie R Faltynek; Abel Lee
Structure-activity studies of a novel series of 5,6-fused heteroaromatic ureas as TRPV1 antagonists.
Bioorganic & medicinal chemistry 2006;14(14):4740-9.
2006: S K Joshi; Joe Mikusa; Gricelda Hernandez; Scott Baker; Char-Chang Shieh; Torben R Neelands; Xu-Feng Zhang; Wende Niforatos; Karen Kage; Ping Han; Douglas Krafte; Connie R Faltynek; James P Sullivan; Michael F Jarvis; Prisca Honore
Involvement of the TTX-resistant sodium channel Nav 1.8 in inflammatory and neuropathic, but not post-operative, pain states.
Pain 2006;123(1-2):75-82.
2006: Derek W Nelson; Robert J Gregg; Michael E Kort; Arturo Perez-Medrano; Eric A Voight; Ying Wang; George Grayson; Marian T Namovic; Diana L Donnelly-Roberts; Wende Niforatos; Prisca Honore; Michael F Jarvis; Connie R Faltynek; William A Carroll
Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists.
Journal of medicinal chemistry 2006;49(12):3659-66.
2006: Bruce R Bianchi; Abel Lee; Michael F Jarvis; Rachid El Kouhen; Robert B Moreland; Connie R Faltynek; Pamela S Puttfarcken
Modulation of human TRPV1 receptor activity by extracellular protons and host cell expression system.
European journal of pharmacology 2006;537(1-3):20-30.
2006: Kathleen H Mortell; David J Anderson; James J Lynch; Sherry L Nelson; Kathy A Sarris; Heath McDonald; Reza S Sabet; Scott Baker; Prisca Honore; Abel Lee; Michael F Jarvis; Murali Gopalakrishnan
Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels.
Bioorganic & medicinal chemistry letters 2006;16(5):1138-41.
2006: Prisca Honore; Carrie L Wade; Chengmin Zhong; Richard R Harris; C Wu; Tariq Ghayur; Yoichiro Iwakura; Michael W Decker; Connie R Faltynek; James Sullivan; Michael F Jarvis
Interleukin-1alphabeta gene-deficient mice show reduced nociceptive sensitivity in models of inflammatory and neuropathic pain but not post-operative pain.
Behavioural brain research 2006;167(2):355-64.
2006: Steve McGaraughty; Katharine L Chu; Connie R Faltynek; Michael F Jarvis
Systemic and site-specific effects of A-425619, a selective TRPV1 receptor antagonist, on wide dynamic range neurons in CFA-treated and uninjured rats.
Journal of neurophysiology 2006;95(1):18-25.
2005: Steve McGaraughty; Michael F Jarvis
Antinociceptive properties of a non-nucleotide P2X3/P2X2/3 receptor antagonist.
Drug news & perspectives 2005;18(8):501-7.
2005: Steve McGaraughty; Prisca Honore; Carol T Wismer; Joe Mikusa; Chang Z Zhu; Heath A McDonald; Bruce R Bianchi; Connie R Faltynek; Michael F Jarvis
Endogenous opioid mechanisms partially mediate P2X3/P2X2/3-related antinociception in rat models of inflammatory and chemogenic pain but not neuropathic pain.
British journal of pharmacology 2005;146(2):180-8.
2005: Xu-Feng Zhang; Ping Han; Connie R Faltynek; Michael F Jarvis; Char-Chang Shieh
Functional expression of P2X7 receptors in non-neuronal cells of rat dorsal root ganglia.
Brain research 2005;1052(1):63-70.
2005: Rachid El Kouhen; Carol S Surowy; Bruce R Bianchi; Torben R Neelands; Heath A McDonald; Wende Niforatos; Arthur Gomtsyan; Abel Lee; Prisca Honore; James P Sullivan; Michael F Jarvis; Connie R Faltynek
A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel and selective transient receptor potential type V1 receptor antagonist, blocks channel activation by vanilloids, heat, and acid.
The Journal of pharmacology and experimental therapeutics 2005;314(1):400-9.
2005: Prisca Honore; Carol T Wismer; Joe Mikusa; Chang Z Zhu; Chengmin Zhong; Donna M Gauvin; Arthur Gomtsyan; Rachid El Kouhen; Abel Lee; Kennan Marsh; James P Sullivan; Connie R Faltynek; Michael F Jarvis
A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats.
The Journal of pharmacology and experimental therapeutics 2005;314(1):410-21.
2005: Richard J Perner; Abel Lee; Meiqun Jiang; Yu Gui Gu; Stanley Didomenico; Erol K Bayburt; Easaw Alexander; Kathy L Kohlhaas; Michael F Jarvis; Elizabeth L Kowaluk; Shripad S Bhagwat
Synthesis and biological evaluation of 6,7-disubstituted 4-aminopyrido[2,3-d]pyrimidines as adenosine kinase inhibitors.
Bioorganic & medicinal chemistry letters 2005;15(11):2803-7.
2005: Mark A Matulenko; Abel Lee; Meiqun Jiang; Robin R Frey; Marlon D Cowart; Erol K Bayburt; Stanley Didomenico; Gregory A Gfesser; Arthur Gomtsyan; Guo Zhu Zheng; Jeffrey A McKie; Andrew O Stewart; Haixia Yu; Kathy L Kohlhaas; Easaw Alexander; Steve McGaraughty; Carol T Wismer; Joe Mikusa; Kennan Marsh; Ronald D Snyder; Marilyn S Diehl; Elizabeth A Kowaluk; Michael F Jarvis; Shripad S Bhagwat
5-(3-Bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-ylamine: structure-activity relationships of 7-substituted heteroaryl analogs as non-nucleoside adenosine kinase inhibitors.
Bioorganic & medicinal chemistry 2005;13(11):3705-20.
2005: Y-W Chen; Diana L Donnelly-Roberts; Marian T Namovic; Gary Gintant; Bryan Cox; Michael F Jarvis; Richard R Harris
Pharmacological characterization of P2X7 receptors in rat peritoneal cells.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2005;54(3):119-26.
2005: Arthur Gomtsyan; Erol K Bayburt; Robert G Schmidt; Guo Zhu Zheng; Richard J Perner; Stanley Didomenico; John R Koenig; Sean Turner; Tammie K Jinkerson; Irene Drizin; Steven M Hannick; Bryan S Macri; Heath A McDonald; Prisca Honore; Carol T Wismer; Kennan Marsh; Jill M Wetter; Kent D Stewart; Tetsuro Oie; Michael F Jarvis; Carol S Surowy; Connie R Faltynek; Abel Lee
Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain: structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine, quinoxaline, and cinnoline moieties.
Journal of medicinal chemistry 2005;48(3):744-52.
2005: Torben R Neelands; Michael F Jarvis; Ping Han; Connie R Faltynek; Carol S Surowy
Acidification of rat TRPV1 alters the kinetics of capsaicin responses.
Molecular pain 2005;1():28.
2005: Steve McGaraughty; Marlon D Cowart; Michael F Jarvis; Robert F Berman
Anticonvulsant and antinociceptive actions of novel adenosine kinase inhibitors.
Current topics in medicinal chemistry 2005;5(1):43-58.
2004: Richard R Harris; Lawrence Black; Sekhar Surapaneni; Teodozyi Kolasa; Sandra Majest; Marian T Namovic; George Grayson; Victoria A Komater; Denise Wilcox; Linda King; Kennan Marsh; Michael F Jarvis; Merrill E Nuss; Hugh Nellans; Lee Pruesser; Glenn A Reinhart; Bryan Cox; Peer Jacobson; Andrew Stewart; Michael J Coghlan; George Carter; Randy L Bell
ABT-963 [2-(3,4-difluoro-phenyl)-4-(3-hydroxy-3-methyl-butoxy)-5-(4-methanesulfonyl-phenyl)-2H-pyridazin-3-one], a highly potent and selective disubstituted pyridazinone cyclooxgenase-2 inhibitor.
The Journal of pharmacology and experimental therapeutics 2004;311(3):904-12.
2004: Katharine L Chu; Connie R Faltynek; Michael F Jarvis; Steve McGaraughty
Increased WDR spontaneous activity and receptive field size in rats following a neuropathic or inflammatory injury: implications for mechanical sensitivity.
Neuroscience letters 2004;372(1-2):123-6.
2004: Richard J Radek; Michael W Decker; Michael F Jarvis
The adenosine kinase inhibitor ABT-702 augments EEG slow waves in rats.
Brain research 2004;1026(1):74-83.
2004: Wende Niforatos; Michael F Jarvis
Electrophysiological characterization of recombinant and native P2X receptors.
Current protocols in pharmacology / editorial board, S.J. Enna (editor-in-chief) ... [et al.] 2004;Chapter 11():Unit 11.9.
2004: Arthur Gomtsyan; Stanley Didomenico; Abel Lee; Andrew O Stewart; Shripad S Bhagwat; Elizabeth A Kowaluk; Michael F Jarvis
Synthesis and biological evaluation of pteridine and pyrazolopyrimidine based adenosine kinase inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(16):4165-8.
2004: Michael F Jarvis; Bruce R Bianchi; John T Uchic; Jayne Cartmell; Abel Lee; Michael Williams; Connie R Faltynek
[3H]A-317491, a novel high-affinity non-nucleotide antagonist that specifically labels human P2X2/3 and P2X3 receptors.
The Journal of pharmacology and experimental therapeutics 2004;310(1):407-16.
2004: Diana L Donnelly-Roberts; Marian T Namovic; Connie R Faltynek; Michael F Jarvis
Mitogen-activated protein kinase and caspase signaling pathways are required for P2X7 receptor (P2X7R)-induced pore formation in human THP-1 cells.
The Journal of pharmacology and experimental therapeutics 2004;308(3):1053-61.
2003: Steve McGaraughty; Carol T Wismer; Chang Z Zhu; Joe Mikusa; Prisca Honore; Katharine L Chu; Abel Lee; Connie R Faltynek; Michael F Jarvis
Effects of A-317491, a novel and selective P2X3/P2X2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration.
British journal of pharmacology 2003;140(8):1381-8.
2003: Richard J Perner; Yu Gui Gu; Abel Lee; Erol K Bayburt; Jeffrey A McKie; Easaw Alexander; Kathy L Kohlhaas; Carol T Wismer; Joe Mikusa; Michael F Jarvis; Elizabeth A Kowaluk; Shripad S Bhagwat
5,6,7-trisubstituted 4-aminopyrido[2,3-d]pyrimidines as novel inhibitors of adenosine kinase.
Journal of medicinal chemistry 2003;46(24):5249-57.
2003: Steve McGaraughty; Katharine L Chu; Robert S Bitner; Brenda Martino; Rachid El Kouhen; Ping Han; Arthur L Nikkel; Edward C Burgard; Connie R Faltynek; Michael F Jarvis
Capsaicin infused into the PAG affects rat tail flick responses to noxious heat and alters neuronal firing in the RVM.
Journal of neurophysiology 2003;90(4):2702-10.
2003: Guo Zhu Zheng; Yue Mao; Abel Lee; John K Pratt; John R Koenig; Richard J Perner; Marlon D Cowart; Gregory A Gfesser; Steve McGaraughty; Katharine L Chu; Chang Zhu; Haixia Yu; Kathy L Kohlhaas; Easaw Alexander; Carol T Wismer; Joe Mikusa; Michael F Jarvis; Elizabeth A Kowaluk; Andrew O Stewart
Adenosine kinase inhibitors: polar 7-substitutent of pyridopyrimidine derivatives improving their locomotor selectivity.
Bioorganic & medicinal chemistry letters 2003;13(18):3041-4.
2003: Torben R Neelands; Edward C Burgard; Marie E Uchic; Heath A McDonald; Wende Niforatos; Connie R Faltynek; Kevin J Lynch; Michael F Jarvis
2', 3'-O-(2,4,6,trinitrophenyl)-ATP and A-317491 are competitive antagonists at a slowly desensitizing chimeric human P2X3 receptor.
British journal of pharmacology 2003;140(1):202-10.
2003: Michael F Jarvis
Contributions of P2X3 homomeric and heteromeric channels to acute and chronic pain.
Expert opinion on therapeutic targets 2003;7(4):513-22.
2003: Carol T Wismer; Connie R Faltynek; Michael F Jarvis; Steve McGaraughty
Distinct neurochemical mechanisms are activated following administration of different P2X receptor agonists into the hindpaw of a rat.
Brain research 2003;965(1-2):187-93.
2003: Gregory A Gfesser; Erol K Bayburt; Marlon D Cowart; Stanley Didomenico; Arthur Gomtsyan; Chih Hung Lee; Andrew O Stewart; Michael F Jarvis; Elizabeth A Kowaluk; Shripad S Bhagwat
Synthesis and structure-activity relationships of 5-heteroatom-substituted pyridopyrimidines as adenosine kinase inhibitors.
European journal of medicinal chemistry 2003;38(3):245-52.
2002: Michael F Jarvis; Edward C Burgard; Steve McGaraughty; Prisca Honore; Kevin Lynch; Timothy Brennan; Alberto Subieta; Tim Van Biesen; Jayne Cartmell; Bruce R Bianchi; Wende Niforatos; Karen Kage; Haixia Yu; Joe Mikusa; Carol T Wismer; Chang Z Zhu; Katharine Chu; Abel Lee; Andrew O Stewart; James S Polakowski; Bryan Cox; Elizabeth A Kowaluk; Michael Williams; James Sullivan; Connie R Faltynek
A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(26):17179-84.
2002: Karen Kage; Wende Niforatos; Chang Z Zhu; Kevin J Lynch; Prisca Honore; Michael F Jarvis
Alteration of dorsal root ganglion P2X3 receptor expression and function following spinal nerve ligation in the rat.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 2002;147(4):511-9.
2002: Michael F Jarvis; Joe Mikusa; Katharine L Chu; Carol T Wismer; Prisca Honore; Elizabeth A Kowaluk; Steve McGaraughty
Comparison of the ability of adenosine kinase inhibitors and adenosine receptor agonists to attenuate thermal hyperalgesia and reduce motor performance in rats.
Pharmacology, biochemistry, and behavior 2002;73(3):573-81.
2002: Prisca Honore; Karen Kage; Joe Mikusa; Andrew T Watt; Joseph F Johnston; Jacqueline R Wyatt; Connie R Faltynek; Michael F Jarvis; Kevin Lynch
Analgesic profile of intrathecal P2X(3) antisense oligonucleotide treatment in chronic inflammatory and neuropathic pain states in rats.
Pain 2002;99(1-2):11-9.
2002: Arthur Gomtsyan; Stanley Didomenico; Abel Lee; Mark A Matulenko; Ki Kim; Elizabeth A Kowaluk; Carol T Wismer; Joe Mikusa; Haixia Yu; Kathy L Kohlhaas; Michael F Jarvis; Shripad S Bhagwat
Design, synthesis, and structure-activity relationship of 6-alkynylpyrimidines as potent adenosine kinase inhibitors.
Journal of medicinal chemistry 2002;45(17):3639-48.
2002: Michael F Jarvis; Haixia Yu; Steve McGaraughty; Carol T Wismer; Joe Mikusa; Chang Zhu; Katharine Chu; Kathy L Kohlhaas; Marlon D Cowart; Chih Hung Lee; Andrew O Stewart; Bryan Cox; James S Polakowski; Elizabeth A Kowaluk
Analgesic and anti-inflammatory effects of A-286501, a novel orally active adenosine kinase inhibitor.
Pain 2002;96(1-2):107-18.
2002: Prisca Honore; Joe Mikusa; Bruce R Bianchi; Heath McDonald; Jayne Cartmell; Connie R Faltynek; Michael F Jarvis
TNP-ATP, a potent P2X3 receptor antagonist, blocks acetic acid-induced abdominal constriction in mice: comparison with reference analgesics.
Pain 2002;96(1-2):99-105.
2002: Michael F Jarvis; Edward C Burgard
Antagonism of P2X3-containing channels: commentary on Spelta et al.
British journal of pharmacology 2002;135(6):1343-4.
2002: Heath A McDonald; Katharine L Chu; Bruce R Bianchi; David G McKenna; Clark A Briggs; Edward C Burgard; Kevin J Lynch; Connie R Faltynek; Jayne Cartmell; Michael F Jarvis
Potent desensitization of human P2X3 receptors by diadenosine polyphosphates.
European journal of pharmacology 2002;435(2-3):135-42.
2001: Chih Hung Lee; Jerome F Daanen; Meiqun Jiang; Haixia Yu; Kathy L Kohlhaas; K Alexander; Michael F Jarvis; E L Kowaluk; Shripad S Bhagwat
Synthesis and biological evaluation of clitocine analogues as adenosine kinase inhibitors.
Bioorganic & medicinal chemistry letters 2001;11(18):2419-22.
2001: Guo Zhu Zheng; C Lee; John K Pratt; Richard J Perner; M Q Jiang; Arthur Gomtsyan; Mark A Matulenko; Yue Mao; John R Koenig; Ki H Kim; Steven W Muchmore; Haixia Yu; Kathy L Kohlhaas; Easaw Alexander; Steve McGaraughty; Katharine L Chu; Carol T Wismer; Joe Mikusa; Michael F Jarvis; Kennan Marsh; Elizabeth A Kowaluk; Shripad S Bhagwat; Andrew O Stewart
Pyridopyrimidine analogues as novel adenosine kinase inhibitors.
Bioorganic & medicinal chemistry letters 2001;11(16):2071-4.
2001: Chang Z Zhu; Joe Mikusa; Katharine L Chu; Marlon D Cowart; Elizabeth A Kowaluk; Michael F Jarvis; Steve McGaraughty
A-134974: a novel adenosine kinase inhibitor, relieves tactile allodynia via spinal sites of action in peripheral nerve injured rats.
Brain research 2001;905(1-2):104-10.
2001: Chih Hung Lee; Meiqun Jiang; Marlon D Cowart; Gregory A Gfesser; Richard J Perner; Ki H Kim; Yu Gui Gu; Michael Williams; Michael F Jarvis; Elizabeth A Kowaluk; Andrew O Stewart; Shripad S Bhagwat
Discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor..
Journal of medicinal chemistry 2001;44(13):2133-8.
2001: Steve McGaraughty; Katharine L Chu; Carol T Wismer; Joe Mikusa; Chang Z Zhu; Marlon D Cowart; Elizabeth A Kowaluk; Michael F Jarvis
Effects of A-134974, a novel adenosine kinase inhibitor, on carrageenan-induced inflammatory hyperalgesia and locomotor activity in rats: evaluation of the sites of action.
The Journal of pharmacology and experimental therapeutics 2001;296(2):501-9.
2001: David L Boyle; Elizabeth A Kowaluk; Michael F Jarvis; C H Lee; Shripad S Bhagwat; M Williams; Gary S Firestein
Anti-inflammatory effects of ABT-702, a novel non-nucleoside adenosine kinase inhibitor, in rat adjuvant arthritis.
The Journal of pharmacology and experimental therapeutics 2001;296(2):495-500.
2001: Marlon D Cowart; Chih Hung Lee; Gregory A Gfesser; Erol K Bayburt; Shripad S Bhagwat; Andrew O Stewart; Haixia Yu; Kathy L Kohlhaas; Steve McGaraughty; Carol T Wismer; Joe Mikusa; Chang Zhu; Easaw Alexander; Michael F Jarvis; Elizabeth A Kowaluk
Structure-activity studies of 5-substituted pyridopyrimidines as adenosine kinase inhibitors.
Bioorganic & medicinal chemistry letters 2001;11(1):83-6.
2001: Steve McGaraughty; Marlon D Cowart; Michael F Jarvis
Recent developments in the discovery of novel adenosine kinase inhibitors: mechanism of action and therapeutic potential.
CNS drug reviews 2001;7(4):415-32.
2001: Michael F Jarvis; Carol T Wismer; E Schweitzer; Haixia Yu; Kevin J Lynch; Edward C Burgard; Elizabeth A Kowaluk
Modulation of BzATP and formalin induced nociception: attenuation by the P2X receptor antagonist, TNP-ATP and enhancement by the P2X(3) allosteric modulator, cibacron blue.
British journal of pharmacology 2001;132(1):259-69.
2000: Philip J Hajduk; Arthur Gomtsyan; Stanley Didomenico; Marlon D Cowart; Erol K Bayburt; Larry Solomon; Jean M Severin; Richard Smith; Karl Walter; Thomas F Holzman; A Stewart; Steve McGaraughty; Michael F Jarvis; Elizabeth A Kowaluk; Stephen W Fesik
Design of adenosine kinase inhibitors from the NMR-based screening of fragments.
Journal of medicinal chemistry 2000;43(25):4781-6.
2000: Edward C Burgard; Wende Niforatos; Tim Van Biesen; Kevin J Lynch; Karen Kage; E Touma; Elizabeth A Kowaluk; Michael F Jarvis
Competitive antagonism of recombinant P2X(2/3) receptors by 2', 3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP).
Molecular pharmacology 2000;58(6):1502-10.
2000: Elizabeth A Kowaluk; Joe Mikusa; Carol T Wismer; Chang Z Zhu; E Schweitzer; James J Lynch; Chih Hung Lee; Meiqun Jiang; Shripad S Bhagwat; Arthur Gomtsyan; Jeffrey A McKie; Bryan Cox; James S Polakowski; G Reinhart; Michael Williams; Michael F Jarvis
ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties. II. In vivo characterization in the rat.
The Journal of pharmacology and experimental therapeutics 2000;295(3):1165-74.
2000: Michael F Jarvis; Haixia Yu; Kathy L Kohlhaas; K Alexander; Chih Hung Lee; Meiqun Jiang; Shripad S Bhagwat; Michael Williams; Elizabeth A Kowaluk
ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholinopyridin-3-yl)pyrido[2, 3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties: I. In vitro characterization and acute antinociceptive effects in the mouse.
The Journal of pharmacology and experimental therapeutics 2000;295(3):1156-64.
2000: Michael Williams; Michael F Jarvis
Purinergic and pyrimidinergic receptors as potential drug targets.
Biochemical pharmacology 2000;59(10):1173-85.
2000: Elizabeth A Kowaluk; Michael F Jarvis
Therapeutic potential of adenosine kinase inhibitors.
Expert opinion on investigational drugs 2000;9(3):551-64.
2000: Michael F Jarvis; Jerry L Wessale; Chang Z Zhu; James J Lynch; Brian D Dayton; Samuel V Calzadilla; Robert J Padley; Terry J Opgenorth; Elizabeth A Kowaluk
ABT-627, an endothelin ET(A) receptor-selective antagonist, attenuates tactile allodynia in a diabetic rat model of neuropathic pain.
European journal of pharmacology 2000;388(1):29-35.
1999: Kevin J Lynch; E Touma; Wende Niforatos; Karen Kage; Edward C Burgard; Tim Van Biesen; Elizabeth A Kowaluk; Michael F Jarvis
Molecular and functional characterization of human P2X(2) receptors.
Molecular pharmacology 1999;56(6):1171-81.
1999: K Alexander; Wende Niforatos; Bruce R Bianchi; Edward C Burgard; Kevin J Lynch; Elizabeth A Kowaluk; Michael F Jarvis; Tim Van Biesen
Allosteric modulation and accelerated resensitization of human P2X(3) receptors by cibacron blue.
The Journal of pharmacology and experimental therapeutics 1999;291(3):1135-42.
1999: Edward C Burgard; Wende Niforatos; Tim Van Biesen; Kevin J Lynch; E Touma; R E Metzger; Elizabeth A Kowaluk; Michael F Jarvis
P2X receptor-mediated ionic currents in dorsal root ganglion neurons.
Journal of neurophysiology 1999;82(3):1590-8.
1999: Bruce R Bianchi; Kevin J Lynch; E Touma; Wende Niforatos; Edward C Burgard; Easaw Alexander; H S Park; Haixia Yu; R Metzger; Elizabeth A Kowaluk; Michael F Jarvis; Tim Van Biesen
Pharmacological characterization of recombinant human and rat P2X receptor subtypes.
European journal of pharmacology 1999;376(1-2):127-38.
1999: DR Britton; Joe Mikusa; Chih Hung Lee; Michael F Jarvis; Michael Williams; Elizabeth A Kowaluk
Site and event specific increase of striatal adenosine release by adenosine kinase inhibition in rats.
Neuroscience letters 1999;266(2):93-6.
1999: Elizabeth A Kowaluk; Kathy L Kohlhaas; AW Bannon; KL Gunther; James J Lynch; Michael F Jarvis
Characterization of the effects of adenosine kinase inhibitors on acute thermal nociception in mice.
Pharmacology, biochemistry, and behavior 1999;63(1):83-91.
1999: James J Lynch; Michael F Jarvis; Elizabeth A Kowaluk
An adenosine kinase inhibitor attenuates tactile allodynia in a rat model of diabetic neuropathic pain.
European journal of pharmacology 1999;364(2-3):141-6.
1998: Elizabeth A Kowaluk; Shripad S Bhagwat; Michael F Jarvis
Adenosine kinase inhibitors.
Current pharmaceutical design 1998;4(5):403-16.
1998: James J Lynch; Easaw Alexander; Michael F Jarvis; Elizabeth A Kowaluk
Inhibition of adenosine kinase during oxygen-glucose deprivation in rat cortical neuronal cultures.
Neuroscience letters 1998;252(3):207-10.