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Hiremagalur Jayaram

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Chemicals & Drugs

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Suhong Xiao; Yonghua Zhang; Hiremagalur N Jayaram; Rehana A Khan; Praveen Kusumanchi; Sally P Stabler; Ying-Sheng Tang; Asok C Antony
Influence of physiologic folate deficiency on human papillomavirus type 16 (HPV16)-harboring human keratinocytes in vitro and in vivo.
Ying-Sheng Tang; Mu Wang; Suhong Xiao; Yonghua Zhang; Deborah K Hansen; Hiremagalur N Jayaram; Rehana A Khan; Asok C Antony
Incrimination of heterogeneous nuclear ribonucleoprotein E1 (hnRNP-E1) as a candidate sensor of physiological folate deficiency.
David W Raches; Paresh Sanghani; Suhong Xiao; Joel A Yalowitz; Asok C Antony; Praveen Kusumanchi; Eric C Long; Hiremagalur N Jayaram
Cloning, expression and characterization of mouse (Mus musculus) nicotinamide 5'-mononucleotide adenylyltransferase-2.

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2012: Suhong Xiao; Yonghua Zhang; Hiremagalur N Jayaram; Rehana A Khan; Praveen Kusumanchi; Sally P Stabler; Ying-Sheng Tang; Asok C Antony
Influence of physiologic folate deficiency on human papillomavirus type 16 (HPV16)-harboring human keratinocytes in vitro and in vivo.
The Journal of biological chemistry 2012;287(15):12559-77.
2011: Ying-Sheng Tang; Mu Wang; Suhong Xiao; Yonghua Zhang; Deborah K Hansen; Hiremagalur N Jayaram; Rehana A Khan; Asok C Antony
Incrimination of heterogeneous nuclear ribonucleoprotein E1 (hnRNP-E1) as a candidate sensor of physiological folate deficiency.
The Journal of biological chemistry 2011;286(45):39100-15.
2011: David W Raches; Paresh Sanghani; Suhong Xiao; Joel A Yalowitz; Asok C Antony; Praveen Kusumanchi; Eric C Long; Hiremagalur N Jayaram
Cloning, expression and characterization of mouse (Mus musculus) nicotinamide 5'-mononucleotide adenylyltransferase-2.
Medicinal chemistry (Shāriqah (United Arab Emirates)) 2011;7(6):718-26.
2011: Andriy M Babsky; Stacy Bennett; Beena George; Mingsheng Huang; Hiremagalur N Jayaram; Shenghong Ju; Gordon McLennan; Navin Bansal
Predicting response to benzamide riboside chemotherapy in hepatocellular carcinoma using apparent diffusion coefficient of water.
Anticancer research 2011;31(6):2045-51.
2011: Loredana Cappellacci; Riccardo Petrelli; Palmarisa Franchetti; Patrizia Vita; Praveen Kusumanchi; Mohineesh Kumar; Hiremagalur N Jayaram; Bingsen Zhou; Yun Yen; Mario Grifantini
Synthesis and biological activity of novel N6-substituted and 2,N6-disubstituted adenine ribo- and 3'-C-methyl-ribonucleosides as antitumor agents.
European journal of medicinal chemistry 2011;46(5):1499-504.
2011: Krzysztof Felczak; Liqiang Chen; Daniel Wilson; Jessica Williams; Robert Vince; Riccardo Petrelli; Hiremagalur N Jayaram; Praveen Kusumanchi; Mohineesh Kumar; Krzysztof W Pankiewicz
Cofactor-type inhibitors of inosine monophosphate dehydrogenase via modular approach: targeting the pyrophosphate binding sub-domain.
Bioorganic & medicinal chemistry 2011;19(5):1594-605.
2010: Liqiang Chen; Riccardo Petrelli; Guangyao Gao; Daniel J Wilson; Garrett T McLean; Hiremagalur N Jayaram; Yuk Y Sham; Krzysztof W Pankiewicz
Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylase based on a cinnamic hydroxamic acid core structure.
Bioorganic & medicinal chemistry 2010;18(16):5950-64.
2009: Suthat Liangpunsakul; Sung-Eun Wou; Kevin D Wineinger; Yan Zeng; Izabela Cyganek; Hiremagalur N Jayaram; David W Crabb
Effects of WY-14,643 on the phosphorylation and activation of AMP-dependent protein kinase.
Archives of biochemistry and biophysics 2009;485(1):10-5.
2009: Shenghong Ju; Gordon McLennan; Stacy L Bennett; Yun Liang; Laurent Bonnac; Krzysztof W Pankiewicz; Hiremagalur N Jayaram
Technical aspects of imaging and transfemoral arterial treatment of N1-S1 tumors in rats: an appropriate model to test the biology and therapeutic response to transarterial treatments of liver cancers.
Journal of vascular and interventional radiology : JVIR 2009;20(3):410-4.
2008: Suthat Liangpunsakul; Sung-Eun Wou; Yan Zeng; Ruth A Ross; Hiremagalur N Jayaram; David W Crabb
Effect of ethanol on hydrogen peroxide-induced AMPK phosphorylation.
American journal of physiology. Gastrointestinal and liver physiology 2008;295(6):G1173-81.
2008: Liqiang Chen; Daniel J Wilson; Nicholas P Labello; Hiremagalur N Jayaram; Krzysztof W Pankiewicz
Mycophenolic acid analogs with a modified metabolic profile.
Bioorganic & medicinal chemistry 2008;16(20):9340-5.
2008: Hiremagalur N Jayaram; Praveen Kusumanchi
Can targeting organic anion transporter polypeptide (OATP) genes play a key role in drug therapy?
Cancer biology & therapy 2008;7(9):1456-9.
2008: Loredana Cappellacci; Palmarisa Franchetti; Patrizia Vita; Riccardo Petrelli; Antonio Lavecchia; Hiremagalur N Jayaram; Philipp Saiko; Geraldine Graser; Thomas Szekeres; Mario Grifantini
Ribose-modified purine nucleosides as ribonucleotide reductase inhibitors. Synthesis, antitumor activity, and molecular modeling of N6-substituted 3'-C-methyladenosine derivatives.
Journal of medicinal chemistry 2008;51(14):4260-9.
2007: Liqiang Chen; Daniel Wilson; Hiremagalur N Jayaram; Krzysztof W Pankiewicz
Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylases for cancer treatment.
Journal of medicinal chemistry 2007;50(26):6685-91.
2007: Liqiang Chen; Guangyao Gao; Krzysztof Felczak; Laurent Bonnac; Steven E Patterson; Daniel Wilson; Eric M Bennett; Hiremagalur N Jayaram; Lizbeth Hedstrom; Krzysztof W Pankiewicz
Probing binding requirements of type I and type II isoforms of inosine monophosphate dehydrogenase with adenine-modified nicotinamide adenine dinucleotide analogues.
Journal of medicinal chemistry 2007;50(23):5743-51.
2007: Liqiang Chen; Guangyao Gao; Laurent Bonnac; Daniel J Wilson; Eric M Bennett; Hiremagalur N Jayaram; Krzysztof W Pankiewicz
Methylenebis(sulfonamide) linked nicotinamide adenine dinucleotide analogue as an inosine monophosphate dehydrogenase inhibitor.
Bioorganic & medicinal chemistry letters 2007;17(11):3152-5.
2007: Laurent Bonnac; Guang-Yao Gao; Liqiang Chen; Steven E Patterson; Hiremagalur N Jayaram; Krzysztof W Pankiewicz
Efficient synthesis of benzamide riboside, a potential anticancer agent.
Nucleosides, nucleotides & nucleic acids 2007;26(10-12):1249-53.
2006: Dominik Rejman; Magda Olesiak; Liqiang Chen; Steven E Patterson; Daniel Wilson; Hiremagalur N Jayaram; Lizbeth Hedstrom; Krzysztof W Pankiewicz
Novel methylenephosphophosphonate analogues of mycophenolic adenine dinucleotide. Inhibition of inosine monophosphate dehydrogenase.
Journal of medicinal chemistry 2006;49(16):5018-22.
2005: Palmarisa Franchetti; Loredana Cappellacci; Michela Pasqualini; Riccardo Petrelli; Patrizia Vita; Hiremagalur N Jayaram; Zsuzsanna Horvath; Thomas Szekeres; Mario Grifantini
Antitumor activity of C-methyl-beta-D-ribofuranosyladenine nucleoside ribonucleotide reductase inhibitors.
Journal of medicinal chemistry 2005;48(15):4983-9.
2005: Palmarisa Franchetti; Loredana Cappellacci; Michela Pasqualini; Riccardo Petrelli; Vetrichelvan Jayaprakasan; Hiremagalur N Jayaram; Donald B Boyd; Manojkumar D Jain; Mario Grifantini
Synthesis, conformational analysis, and biological activity of new analogues of thiazole-4-carboxamide adenine dinucleotide (TAD) as IMP dehydrogenase inhibitors.
Bioorganic & medicinal chemistry 2005;13(6):2045-53.
2005: Suhong Xiao; Deborah K Hansen; Elizabeth T M Horsley; Ying-Sheng Tang; Rehana A Khan; Sally P Stabler; Hiremagalur N Jayaram; Asok C Antony
Maternal folate deficiency results in selective upregulation of folate receptors and heterogeneous nuclear ribonucleoprotein-E1 associated with multiple subtle aberrations in fetal tissues.
Birth defects research. Part A, Clinical and molecular teratology 2005;73(1):6-28.
2005: Vijaya L Damaraju; Frank Visser; Jing Zhang; Delores Mowles; Amy M L Ng; James D Young; Hiremagalur N Jayaram; Carol E Cass
Role of human nucleoside transporters in the cellular uptake of two inhibitors of IMP dehydrogenase, tiazofurin and benzamide riboside.
Molecular pharmacology 2005;67(1):273-9.
2004: Yonghua Zhang; Lili Guo; Roger W Roeske; Asok C Antony; Hiremagalur N Jayaram
Pteroyl-gamma-glutamate-cysteine synthesis and its application in folate receptor-mediated cancer cell targeting using folate-tethered liposomes.
Analytical biochemistry 2004;332(1):168-77.
2004: Krzysztof W Pankiewicz; Steven E Patterson; Paul L Black; Hiremagalur N Jayaram; Dipesh Risal; Barry M Goldstein; Lieven Stuyver; Ray F Schinazi
Cofactor mimics as selective inhibitors of NAD-dependent inosine monophosphate dehydrogenase (IMPDH)--the major therapeutic target.
Current medicinal chemistry 2004;11(7):887-900.
2004: Joel A Yalowitz; Suhong Xiao; Mangatt P Biju; Asok C Antony; Oscar W Cummings; Mark A Deeg; Hiremagalur N Jayaram
Characterization of human brain nicotinamide 5'-mononucleotide adenylyltransferase-2 and expression in human pancreas.
The Biochemical journal 2004;377(Pt 2):317-26.
2004: Asok C Antony; Ying-Sheng Tang; Rehana A Khan; Mangatt P Biju; Xiangli Xiao; Qing-Jun Li; Xin-Lai Sun; Hiremagalur N Jayaram; Sally P Stabler
Translational upregulation of folate receptors is mediated by homocysteine via RNA-heterogeneous nuclear ribonucleoprotein E1 interactions.
The Journal of clinical investigation 2004;113(2):285-301.
2003: M Radhakrishna Pillai; Priya Chacko; L A Kesari; P G Jayaprakash; Hiremagalur N Jayaram; Asok C Antony
Expression of folate receptors and heterogeneous nuclear ribonucleoprotein E1 in women with human papillomavirus mediated transformation of cervical tissue to cancer.
Journal of clinical pathology 2003;56(8):569-74.
2003: Loredana Cappellacci; G Barboni; Palmarisa Franchetti; C Martini; Hiremagalur N Jayaram; Mario Grifantini
A new tiazofurin pronucleotide: synthesis and biological evaluation of cyclosaligenyl-tiazofurin monophosphate.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):869-72.
2002: Joel A Yalowitz; Krzysztof W Pankiewicz; Steven E Patterson; Hiremagalur N Jayaram
Cytotoxicity and cellular differentiation activity of methylenebis(phosphonate) analogs of tiazofurin and mycophenolic acid adenine dinucleotide in human cancer cell lines.
Cancer letters 2002;181(1):31-8.
2002: Hiremagalur N Jayaram; Joel A Yalowitz; Francisco Arguello; John F Greene
Toxicity and efficacy of benzamide riboside in cancer chemotherapy models.
Current medicinal chemistry 2002;9(7):787-92.
2002: Joel A Yalowitz; Hiremagalur N Jayaram
Modulation of cytotoxicity of benzamide riboside by expression of NMN adenylyltransferase.
Current medicinal chemistry 2002;9(7):749-58.
2002: Kamran Gharehbaghi; Werner Grünberger; Hiremagalur N Jayaram
Studies on the mechanism of action of benzamide riboside: a novel inhibitor of IMP dehydrogenase.
Current medicinal chemistry 2002;9(7):743-8.
2002: Krzysztof W Pankiewicz; Kyoichi A Watanabe; Krystyna B Lesiak-Watanabe; Barry M Goldstein; Hiremagalur N Jayaram
The chemistry of nicotinamide adenine dinucleotide (NAD) analogues containing C-nucleosides related to nicotinamide riboside.
Current medicinal chemistry 2002;9(7):733-41.
2002: Michael Grusch; Doris Polgar; S Gfatter; Katharina Leuhuber; Simone Huettenbrenner; Christina Leisser; Gerhard Fuhrmann; Fekadu Kassie; Herta Steinkellner; K Smid; GJ Peters; Hiremagalur N Jayaram; Waltraud Klepal; Thomas Szekeres; Siegfried Knasmüller; Georg Krupitza
Maintenance of ATP favours apoptosis over necrosis triggered by benzamide riboside.
Cell death and differentiation 2002;9(2):169-78.
2002: Krzysztof W Pankiewicz; Krystyna B Lesiak-Watanabe; Kyoichi A Watanabe; Steven E Patterson; Hiremagalur N Jayaram; Joel A Yalowitz; Michael D Miller; Michael M Seidman; Alokes Majumdar; Gerd Prehna; Barry M Goldstein
Novel mycophenolic adenine bis(phosphonate) analogues as potential differentiation agents against human leukemia.
Journal of medicinal chemistry 2002;45(3):703-12.
2001: X Xiao; Ying-Sheng Tang; J Y Mackins; Xin-Lai Sun; Hiremagalur N Jayaram; Deborah K Hansen; Asok C Antony
Isolation and characterization of a folate receptor mRNA-binding trans-factor from human placenta. Evidence favoring identity with heterogeneous nuclear ribonucleoprotein E1.
The Journal of biological chemistry 2001;276(44):41510-7.
2001: Alexandra Salamon; Birgit Hagenauer; Theresia Thalhammer; Thomas Szekeres; K Krohn; Hiremagalur N Jayaram; Walter Jäger
Metabolism and disposition of the novel antileukaemic drug, benzamide riboside, in the isolated perfused rat liver.
Life sciences 2001;69(21):2489-502.
2001: Palmarisa Franchetti; S Marchetti; Loredana Cappellacci; Joel A Yalowitz; Hiremagalur N Jayaram; Barry M Goldstein; Mario Grifantini
A new C-nucleoside analogue of tiazofurin: synthesis and biological evaluation of 2-beta-D-ribofuranosylimidazole-4-carboxamide (imidazofurin).
Bioorganic & medicinal chemistry letters 2001;11(1):67-9.
2000: Kamran Gharehbaghi; Thomas Szekeres; Joel A Yalowitz; Monika Fritzer-Szekeres; Y G Pommier; Hiremagalur N Jayaram
Sensitizing human colon carcinoma HT-29 cells to cisplatin by cyclopentenylcytosine, in vitro and in vivo.
Life sciences 2000;68(1):1-11.
2000: Kamran Gharehbaghi; Andreas Kubin; Michael Grusch; E Gharehbaghi-Schnell; Franz Wierrani; Hiremagalur N Jayaram; W Grunberger; Thomas Szekeres
Photodynamic action of meta-tetrahydroxyphenylchlorin (mTHPC) on an ovarian cancer cell line.
Anticancer research 2000;20(4):2647-52.
2000: Joel A Yalowitz; Hiremagalur N Jayaram
Molecular targets of guanine nucleotides in differentiation, proliferation and apoptosis.
Anticancer research 2000;20(4):2329-38.
2000: Palmarisa Franchetti; S Marchetti; Loredana Cappellacci; Hiremagalur N Jayaram; Joel A Yalowitz; Barry M Goldstein; Jean Louis Barascut; David Dukhan; Jean-Louis Imbach; Mario Grifantini
Synthesis, conformational analysis, and biological activity of C-thioribonucleosides related to tiazofurin.
Journal of medicinal chemistry 2000;43(7):1264-70.
1999: Michael Grusch; Georg Rosenberger; Gerhard Fuhrmann; K Braun; B Titscher; Thomas Szekeres; M Fritzer-Skekeres; G Oberhuber; K Krohn; M Hengstschlaeger; Georg Krupitza; Hiremagalur N Jayaram
Benzamide riboside induces apoptosis independent of Cdc25A expression in human ovarian carcinoma N.1 cells.
Cell death and differentiation 1999;6(8):736-44.
1999: Hiremagalur N Jayaram; D A Cooney; Michael Grusch; Georg Krupitza
Consequences of IMP dehydrogenase inhibition, and its relationship to cancer and apoptosis.
Current medicinal chemistry 1999;6(7):561-74.
1999: Xin-Lai Sun; Hiremagalur N Jayaram; Kamran Gharehbaghi; Q J Li; X Xiao; Asok C Antony
Modulation of the cytotoxicity of 3'-azido-3'-deoxythymidine and methotrexate after transduction of folate receptor cDNA into human cervical carcinoma: identification of a correlation between folate receptor expression and thymidine kinase activity.
Cancer research 1999;59(4):940-6.
1999: Kamran Gharehbaghi; W Zhen; Monika Fritzer-Szekeres; Thomas Szekeres; Hiremagalur N Jayaram
Studies on the antitumor activity and biochemical actions of cyclopentenyl cytosine against human colon carcinoma HT-29 in vitro and in vivo.
Life sciences 1999;64(2):103-12.
1998: Palmarisa Franchetti; Loredana Cappellacci; P Perlini; Hiremagalur N Jayaram; A Butler; B P Schneider; FR Collart; Eliezer Huberman; Mario Grifantini
Isosteric analogues of nicotinamide adenine dinucleotide derived from furanfurin, thiophenfurin, and selenophenfurin as mammalian inosine monophosphate dehydrogenase (type I and II) inhibitors.
Journal of medicinal chemistry 1998;41(10):1702-7.
1997: Palmarisa Franchetti; Loredana Cappellacci; G A Sheikha; Hiremagalur N Jayaram; V V Gurudutt; T Sint; B P Schneider; W D Jones; Barry M Goldstein; G Perra; A De Montis; Anna Giulia Loi; Paolo La Colla; Mario Grifantini
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.
Journal of medicinal chemistry 1997;40(11):1731-7.
1996: ST Pottratz; T D Hall; WM Scribner; Hiremagalur N Jayaram; Viswanathan Natarajan
P-selectin-mediated attachment of small cell lung carcinoma to endothelial cells.
The American journal of physiology 1996;271(6 Pt 1):L918-23.
1996: Hiremagalur N Jayaram; A O'Connor; M R Grant; H Yang; P A Grieco; D A Cooney
Biochemical consequences of resistance to a recently discovered IMP dehydrogenase inhibitor, benzamide riboside, in human myelogenous leukemia K562 cells.
Journal of experimental therapeutics & oncology 1996;1(5):278-85.
1996: Joseph J Barchi; D A Cooney; G S Ahluwalia; Kamran Gharehbaghi; J M Covey; I Hochman; KD Paull; Hiremagalur N Jayaram
Studies on the mechanism of action of 1-beta-D-arabinofuranosyl-5-azacytosine (fazarabine) in mammalian lymphoblasts.
Journal of experimental therapeutics & oncology 1996;1(3):191-203.
1995: Palmarisa Franchetti; Loredana Cappellacci; Mario Grifantini; A Barzi; Giuseppe Nocentini; H Yang; A O'Connor; Hiremagalur N Jayaram; C Carrell; Barry M Goldstein
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
Journal of medicinal chemistry 1995;38(19):3829-37.
1995: X L Sun; Brian Murphy; Q J Li; S Gullapalli; J Mackins; Hiremagalur N Jayaram; Arun Srivastava; A C Antony
Transduction of folate receptor cDNA into cervical carcinoma cells using recombinant adeno-associated virions delays cell proliferation in vitro and in vivo.
The Journal of clinical investigation 1995;96(3):1535-47.
1994: Thomas Szekeres; M Fritzer; Herbert Strobl; Kamran Gharehbaghi; G Findenig; Howard L Elford; C Lhotka; H J Schoen; Hiremagalur N Jayaram
Synergistic growth inhibitory and differentiating effects of trimidox and tiazofurin in human promyelocytic leukemia HL-60 cells.
Blood 1994;84(12):4316-21.
1994: Kamran Gharehbaghi; A Sreenath; Z Hao; KD Paull; Thomas Szekeres; D A Cooney; K Krohn; Hiremagalur N Jayaram
Comparison of biochemical parameters of benzamide riboside, a new inhibitor of IMP dehydrogenase, with tiazofurin and selenazofurin.
Biochemical pharmacology 1994;48(7):1413-9.
1994: Viswanathan Natarajan; Hiremagalur N Jayaram; WM Scribner; Joe G. N. Garcia
Activation of endothelial cell phospholipase D by sphingosine and sphingosine-1-phosphate.
American journal of respiratory cell and molecular biology 1994;11(2):221-9.
1994: Kamran Gharehbaghi; Gem S Burgess; F R Collart; S Litz-Jackson; E Huberman; Hiremagalur N Jayaram; H Scott Boswell
p210 bcr-abl confers overexpression of inosine monophosphate dehydrogenase: an intrinsic pathway to drug resistance mediated by oncogene.
Leukemia 1994;8(8):1257-63.
1994: Kamran Gharehbaghi; KD Paull; James A Kelley; Joseph J Barchi; Victor E Marquez; D A Cooney; Anne Monks; Dominic A Scudiero; K Krohn; Hiremagalur N Jayaram
Cytotoxicity and characterization of an active metabolite of benzamide riboside, a novel inhibitor of IMP dehydrogenase.
International journal of cancer. Journal international du cancer 1994;56(6):892-9.
1994: Thomas Szekeres; Kamran Gharehbaghi; M Fritzer; M Woody; Arun Srivastava; B van't Riet; Hiremagalur N Jayaram; Howard L Elford
Biochemical and antitumor activity of trimidox, a new inhibitor of ribonucleotide reductase.
Cancer chemotherapy and pharmacology 1994;34(1):63-6.
1993: R A Mandanas; D S Leibowitz; Kamran Gharehbaghi; Tetsuzo Tauchi; Gem S Burgess; K Miyazawa; Hiremagalur N Jayaram; H Scott Boswell
Role of p21 RAS in p210 bcr-abl transformation of murine myeloid cells.
Blood 1993;82(6):1838-47.
1993: K Pillwein; K Schuchter; G Ressmańn; Kamran Gharehbaghi; A Knoflach; B Cermak; Hiremagalur N Jayaram; S M Szalay; Thomas Szekeres; Peter Chiba
Cytotoxicity, differentiating activity and metabolism of tiazofurin in human neuroblastoma cells.
International journal of cancer. Journal international du cancer 1993;55(1):92-5.
1993: Krzysztof W Pankiewicz; J Zeidler; L A Ciszewski; J E Bell; Barry M Goldstein; Hiremagalur N Jayaram; KA Watanabe
Synthesis of isosteric analogues of nicotinamide adenine dinucleotide containing C-nucleotide of nicotinamide or picolinamide.
Journal of medicinal chemistry 1993;36(13):1855-9.
1993: Hiremagalur N Jayaram; W Zhen; Kamran Gharehbaghi
Biochemical consequences of resistance to tiazofurin in human myelogenous leukemic K562 cells.
Cancer research 1993;53(10 Suppl):2344-8.
1992: Hiremagalur N Jayaram; Kamran Gharehbaghi; N H Jayaram; J Rieser; K Krohn; KD Paull
Cytotoxicity of a new IMP dehydrogenase inhibitor, benzamide riboside, to human myelogenous leukemia K562 cells.
Biochemical and biophysical research communications 1992;186(3):1600-6.
1992: Hiremagalur N Jayaram; E Lapis; Guido Tricot; P Kneebone; E Paulik; W Zhen; G P Engeler; R Hoffman; George Weber
Clinical pharmacokinetic study of tiazofurin administered as a 1-hour infusion.
International journal of cancer. Journal international du cancer 1992;51(2):182-8.
1992: Hiremagalur N Jayaram; K Murayama; K Pillwein; W Zhen; George Weber
Schedule-dependent synergistic action of tiazofurin and dipyridamole on hepatoma 3924A cells.
Cancer chemotherapy and pharmacology 1992;31(2):93-6.
1992: W Zhen; Hiremagalur N Jayaram; George Weber
Antitumor activity of tiazofurin in human colon carcinoma HT-29.
Cancer investigation 1992;10(6):505-11.
1991: W Zhen; Hiremagalur N Jayaram; Victor E Marquez; B M Goldstein; D A Cooney; George Weber
Cytotoxicity of tiazofurin and its arabinose and xylose analogues in K562 cells.
Biochemical and biophysical research communications 1991;180(2):933-8.
1991: E Paulik; Hiremagalur N Jayaram; George Weber
Determination of NAD pyrophosphorylase activity in biological samples.
Analytical biochemistry 1991;197(1):143-8.
1991: George Weber; M Nagai; Y Natsumeda; J N Eble; Hiremagalur N Jayaram; E Paulik; W N Zhen; R Hoffman; Guido Tricot
Tiazofurin down-regulates expression of c-Ki-ras oncogene in a leukemic patient.
Cancer communications 1991;3(3):61-6.
1991: W Zhen; Hiremagalur N Jayaram; George Weber
Determination of thiazole-4-carboxamide adenine dinucleotide (TAD) levels in mononuclear cells of leukemic patients treated with tiazofurin.
Biochemical pharmacology 1991;41(2):281-6.
1991: George Weber; M Nagai; Y Natsumeda; S Ichikawa; H Nakamura; J N Eble; Hiremagalur N Jayaram; W N Zhen; E Paulik; R Hoffman
Regulation of de novo and salvage pathways in chemotherapy.
Advances in enzyme regulation 1991;31():45-67.
1990: Guido Tricot; Hiremagalur N Jayaram; George Weber; R Hoffman
Tiazofurin: biological effects and clinical uses.
International journal of cell cloning 1990;8(3):161-70.
1990: Hiremagalur N Jayaram; M S Lui; J Plowman; K Pillwein; M A Reardon; William L. Elliott; George Weber
Oncolytic activity and mechanism of action of a novel L-cysteine derivative, L-cysteine, ethyl ester, S-(N-methylcarbamate) monohydrochloride.
Cancer chemotherapy and pharmacology 1990;26(2):88-92.
1990: George Weber; Y Yamaji; M Nagai; Y Natsumeda; Hiremagalur N Jayaram; W N Zhen; E Paulik
Tiazofurin action in leukemia: evidence for down-regulation of oncogenes and synergism with retinoic acid.
Advances in enzyme regulation 1990;30():35-45.
1990: Maria Teresa Rizzo; Guido Tricot; R Hoffman; Hiremagalur N Jayaram; George Weber; Joe G. N. Garcia; Denis English
Inosine monophosphate dehydrogenase inhibitors. Probes for investigations of the functions of guanine nucleotide binding proteins in intact cells.
Cellular signalling 1990;2(6):509-19.
1989: Guido Tricot; Hiremagalur N Jayaram; E Lapis; Y Natsumeda; Craig Nichols; P Kneebone; Nyla A Heerema; George Weber; R Hoffman
Biochemically directed therapy of leukemia with tiazofurin, a selective blocker of inosine 5'-phosphate dehydrogenase activity.
Cancer research 1989;49(13):3696-701.
1989: George Weber; Y Yamaji; Edith Olah; Y Natsumeda; Hiremagalur N Jayaram; E Lapis; W N Zhen; N Prajda; R Hoffman; Guido Tricot
Clinical and molecular impact of inhibition of IMP dehydrogenase activity by tiazofurin.
Advances in enzyme regulation 1989;28():335-56.
1989: Y Yamada; Y Natsumeda; Y Yamaji; Hiremagalur N Jayaram; Guido Tricot; R Hoffman; George Weber
IMP dehydrogenase: inhibition by the anti-leukemic drug, tiazofurin.
Leukemia research 1989;13(2):179-84.
1988: K Pillwein; Hiremagalur N Jayaram; G Weber
Studies of purine and tiazofurin metabolism in drug sensitive human chronic myelogenous leukemia K 562 cells.
Blut 1988;57(2):97-100.
1988: K Pillwein; M A Reardon; Hiremagalur N Jayaram; Y Natsumeda; William L. Elliott; Mary Faderan; N Prajda; Wolfgang Sperl; George Weber
Insulin regulatory effects on purine- and pyrimidine metabolism in alloxan diabetic rat liver.
Pädiatrie und Pädologie 1988;23(2):135-44.
1988: George Weber; Hiremagalur N Jayaram; E Lapis; Y Natsumeda; Y Yamada; Y Yamaji; Guido Tricot; R Hoffman
Enzyme-pattern-targeted chemotherapy with tiazofurin and allopurinol in human leukemia.
Advances in enzyme regulation 1988;27():405-33.
1987: Guido Tricot; Hiremagalur N Jayaram; Craig Nichols; K Pennington; E Lapis; George Weber; R Hoffman
Hematological and biochemical action of tiazofurin (NSC 286193) in a case of refractory acute myeloid leukemia.
Cancer research 1987;47(18):4988-91.
1987: K Pillwein; Hiremagalur N Jayaram; G Weber
Effect of ischemia on nucleosides and bases in rat liver and hepatoma 3924A.
Cancer research 1987;47(12):3092-6.
1987: George Weber; Hiremagalur N Jayaram; K Pillwein; Y Natsumeda; M A Reardon; Y S Zhen
Salvage pathways as targets of chemotherapy.
Advances in enzyme regulation 1987;26():335-52.
1986: Hiremagalur N Jayaram; K Pillwein; Craig Nichols; R Hoffman; G Weber
Selective sensitivity to tiazofurin of human leukemic cells.
Biochemical pharmacology 1986;35(12):2029-32.
1986: Hiremagalur N Jayaram; K Pillwein; M S Lui; Mary Faderan; George Weber
Mechanism of resistance to tiazofurin in hepatoma 3924A.
Biochemical pharmacology 1986;35(4):587-93.
1986: K Pillwein; Hiremagalur N Jayaram; G Wever
[The biochemistry of the cancer cell. Purine and pyrimidine metabolism].
Pädiatrie und Pädologie 1986;21(4):323-34.
1985: George Weber; M S Lui; Hiremagalur N Jayaram; K Pillwein; Y Natsumeda; Mary Faderan; M A Reardon
Regulation of purine and pyrimidine metabolism by insulin and by resistance to tiazofurin.
Advances in enzyme regulation 1985;23():81-99.
1985: G Gebeyehu; Victor E Marquez; A Van Cott; D A Cooney; James A Kelley; Hiremagalur N Jayaram; G S Ahluwalia; R L Dion; Y A Wilson; David G Johns
Ribavirin, tiazofurin, and selenazofurin: mononucleotides and nicotinamide adenine dinucleotide analogues. Synthesis, structure, and interactions with IMP dehydrogenase.
Journal of medicinal chemistry 1985;28(1):99-105.
1984: M S Lui; Mary Faderan; J J Liepnieks; Y Natsumeda; Edith Olah; Hiremagalur N Jayaram; George Weber
Modulation of IMP dehydrogenase activity and guanylate metabolism by tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide).
The Journal of biological chemistry 1984;259(8):5078-82.
1984: S T Arnold; Hiremagalur N Jayaram; G R Harper; C L Litterst; L Malspeis; J J DeSouza; A E Staubus; G S Ahluwalia; Y A Wilson; D A Cooney
The disposition and metabolism of tiazofurin in rodents, rabbits, and dogs.
Drug metabolism and disposition: the biological fate of chemicals 1984;12(2):165-73.
1983: Hiremagalur N Jayaram; G S Ahluwalia; R L Dion; G Gebeyehu; Victor E Marquez; James A Kelley; R K Robins; D A Cooney; David G Johns
Conversion of 2-beta-D-ribofuranosylselenazole-4-carboxamide to an analogue of NAD with potent IMP dehydrogenase-inhibitory properties.
Biochemical pharmacology 1983;32(17):2633-6.
1983: G Gebeyehu; Victor E Marquez; James A Kelley; D A Cooney; Hiremagalur N Jayaram; David G Johns
Synthesis of thiazole-4-carboxamide adenine dinucleotide. A powerful inhibitor of IMP dehydrogenase.
Journal of medicinal chemistry 1983;26(6):922-5.
1983: D A Cooney; Hiremagalur N Jayaram; R I Glazer; James A Kelley; Victor E Marquez; G Gebeyehu; A C Van Cott; L A Zwelling; David G Johns
Studies on the mechanism of action of tiazofurin metabolism to an analog of NAD with potent IMP dehydrogenase-inhibitory activity.
Advances in enzyme regulation 1983;21():271-303.
1982: D A Cooney; Hiremagalur N Jayaram; G Gebeyehu; C R Betts; James A Kelley; Victor E Marquez; David G Johns
The conversion of 2-beta-D-ribofuranosylthiazole-4-carboxamide to an analogue of NAD with potent IMP dehydrogenase-inhibitory properties.
Biochemical pharmacology 1982;31(11):2133-6.