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Mark Jedrzejas

Research Profile

Concepts & Ideas

Living Beings

Chemicals & Drugs

Genes & Molecular Sequences

Amino Acid Sequences

Procedures

Anatomy

Spores, Bacterial

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Publications

TOP 3
Harshad Joshi; Mark J Jedrzejas; Bert L de Groot
Domain motions of hyaluronan lyase underlying processive hyaluronan translocation.
Robert Stern; Mark J Jedrzejas
Carbohydrate polymers at the center of life's origins: the importance of molecular processivity.
Ki-Seog Lee; Daniela Bumbaca; Jeffrey Kosman; Peter Setlow; Mark J Jedrzejas
Structure of a protein-DNA complex essential for DNA protection in spores of Bacillus species.

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All Publications

2009: Harshad Joshi; Mark J Jedrzejas; Bert L de Groot
Domain motions of hyaluronan lyase underlying processive hyaluronan translocation.
Proteins 2009;76(1):30-46.
2008: Robert Stern; Mark J Jedrzejas
Carbohydrate polymers at the center of life's origins: the importance of molecular processivity.
Chemical reviews 2008;108(12):5061-85.
2008: Ki-Seog Lee; Daniela Bumbaca; Jeffrey Kosman; Peter Setlow; Mark J Jedrzejas
Structure of a protein-DNA complex essential for DNA protection in spores of Bacillus species.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(8):2806-11.
2007: Robert Stern; Grigorij Kogan; Mark J Jedrzejas; Ladislav Soltés
The many ways to cleave hyaluronan.
Biotechnology advances 2007;25(6):537-57.
2007: Mark J Jedrzejas
Unveiling molecular mechanisms of bacterial surface proteins: Streptococcus pneumoniae as a model organism for structural studies.
Cellular and molecular life sciences : CMLS 2007;64(21):2799-822.
2007: Stephen J Kelly; Jie Li; Peter Setlow; Mark J Jedrzejas
Structure, flexibility, and mechanism of the Bacillus stearothermophilus RecU Holliday junction resolvase.
Proteins 2007;68(4):961-71.
2007: Daniela Bumbaca; Jeffrey Kosman; Peter Setlow; R Keith Henderson; Mark J Jedrzejas
Crystallization and preliminary X-ray analysis of the complex between a Bacillus subtilis alpha/beta-type small acid-soluble spore protein and DNA.
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 6):503-6.
2007: Daniela Bumbaca; James E Littlejohn; Hannah Nayakanti; Alexander H Lucas; Daniel J Rigden; Michael Galperin; Mark J Jedrzejas
Genome-based identification and characterization of a putative mucin-binding protein from the surface of Streptococcus pneumoniae.
Proteins 2007;66(3):547-58.
2007: Masatoshi Nukui; Luciane V Mello; James E Littlejohn; Barbara Setlow; Peter Setlow; Kijeong Kim; Terrance Leighton; Mark J Jedrzejas
Structure and molecular mechanism of Bacillus anthracis cofactor-independent phosphoglycerate mutase: a crucial enzyme for spores and growing cells of Bacillus species.
Biophysical journal 2007;92(3):977-88.
2006: Daniel J Rigden; Alexander Botzki; Masatoshi Nukui; R Brandon Mewbourne; Ejvis Lamani; Stephan Braun; Erwin von Angerer; Günther Bernhardt; Stefan Dove; Armin Buschauer; Mark J Jedrzejas
Design of new benzoxazole-2-thione-derived inhibitors of Streptococcus pneumoniae hyaluronan lyase: structure of a complex with a 2-phenylindole.
Glycobiology 2006;16(8):757-65.
2006: Ejvis Lamani; R Brandon Mewbourne; Damona S Fletcher; Sergei D Maltsev; Leonid L Danilov; Vladimir V Veselovsky; Antonina V Lozanova; Natalia Ya Grigorieva; Olga A Pinsker; Jun Xing; W Thomas Forsee; Herbert C Cheung; John S Schutzbach; Vladimir N Shibaev; Mark J Jedrzejas
Structural studies and mechanism of Saccharomyces cerevisiae dolichyl-phosphate-mannose synthase: insights into the initial step of synthesis of dolichyl-phosphate-linked oligosaccharide chains in membranes of endoplasmic reticulum.
Glycobiology 2006;16(7):666-78.
2006: Daniel J Rigden; James E Littlejohn; Harshad Joshi; Bert L de Groot; Mark J Jedrzejas
Alternate structural conformations of Streptococcus pneumoniae hyaluronan lyase: insights into enzyme flexibility and underlying molecular mechanism of action.
Journal of molecular biology 2006;358(4):1165-78.
2006: Mark J Jedrzejas
Unveiling molecular mechanisms of pneumococcal surface protein A interactions with antibodies and lactoferrin.
Clinica chimica acta; international journal of clinical chemistry 2006;367(1-2):1-10.
2006: Robert Stern; Mark J Jedrzejas
Hyaluronidases: their genomics, structures, and mechanisms of action.
Chemical reviews 2006;106(3):818-39.
2005: Mark J Jedrzejas; Robert Stern
Structures of vertebrate hyaluronidases and their unique enzymatic mechanism of hydrolysis.
Proteins 2005;61(2):227-38.
2004: Alexander Botzki; Daniel J Rigden; Stephan Braun; Masatoshi Nukui; Sunnhild Salmen; Julia Hoechstetter; Günther Bernhardt; Stefan Dove; Mark J Jedrzejas; Armin Buschauer
L-Ascorbic acid 6-hexadecanoate, a potent hyaluronidase inhibitor. X-ray structure and molecular modeling of enzyme-inhibitor complexes.
The Journal of biological chemistry 2004;279(44):45990-7.
2004: Daniela Bumbaca; James E Littlejohn; Hannah Nayakanti; Daniel J Rigden; Michael Galperin; Mark J Jedrzejas
Sequence analysis and characterization of a novel fibronectin-binding repeat domain from the surface of Streptococcus pneumoniae.
Omics : a journal of integrative biology 2004;8(4):341-56.
2004: Mark J Jedrzejas
Extracellular virulence factors of Streptococcus pneumoniae.
Frontiers in bioscience : a journal and virtual library 2004;9():891-914.
2003: Daniel J Rigden; Mark J Jedrzejas
Structures of Streptococcus pneumoniae hyaluronate lyase in complex with chondroitin and chondroitin sulfate disaccharides. Insights into specificity and mechanism of action.
The Journal of biological chemistry 2003;278(50):50596-606.
2003: Jan Kolberg; Audun Aase; Gunnhild Rødal; James E Littlejohn; Mark J Jedrzejas
Epitope mapping of pneumococcal surface protein A of strain Rx1 using monoclonal antibodies and molecular structure modelling.
FEMS immunology and medical microbiology 2003;39(3):265-73.
2003: Daniel J Rigden; Mark J Jedrzejas
Genome-based identification of a carbohydrate binding module in Streptococcus pneumoniae hyaluronate lyase.
Proteins 2003;52(2):203-11.
2003: Daniel J Rigden; Mark J Jedrzejas; Olga V Moroz; Michael Galperin
Structural diversity of calcium-binding proteins in bacteria: single-handed EF-hands?
Trends in microbiology 2003;11(7):295-7.
2003: Daniel J Rigden; Mark J Jedrzejas; Luciane V de Mello
Identification and analysis of catalytic TIM barrel domains in seven further glycoside hydrolase families.
FEBS letters 2003;544(1-3):103-11.
2003: Daniel J Rigden; Ejvis Lamani; Luciane V Mello; James E Littlejohn; Mark J Jedrzejas
Insights into the catalytic mechanism of cofactor-independent phosphoglycerate mutase from X-ray crystallography, simulated dynamics and molecular modeling.
Journal of molecular biology 2003;328(4):909-20.
2003: Daniel J Rigden; Mark J Jedrzejas; Michael Galperin
Amidase domains from bacterial and phage autolysins define a family of gamma-D,L-glutamate-specific amidohydrolases.
Trends in biochemical sciences 2003;28(5):230-4.
2003: Daniel J Rigden; Mark J Jedrzejas; Michael Galperin
An extracellular calcium-binding domain in bacteria with a distant relationship to EF-hands.
FEMS microbiology letters 2003;221(1):103-10.
2003: Masatoshi Nukui; Kenneth B Taylor; David T McPherson; Mark K Shigenaga; Mark J Jedrzejas
The function of hydrophobic residues in the catalytic cleft of Streptococcus pneumoniae hyaluronate lyase. Kinetic characterization of mutant enzyme forms.
The Journal of biological chemistry 2003;278(5):3079-88.
2003: Daniel J Rigden; James E Littlejohn; Keith Henderson; Mark J Jedrzejas
Structures of phosphate and trivanadate complexes of Bacillus stearothermophilus phosphatase PhoE: structural and functional analysis in the cofactor-dependent phosphoglycerate mutase superfamily.
Journal of molecular biology 2003;325(3):411-20.
2003: Mark J Jedrzejas; Wendy J M Huang
Bacillus species proteins involved in spore formation and degradation: from identification in the genome, to sequence analysis, and determination of function and structure.
Critical reviews in biochemistry and molecular biology 2003;38(3):173-98.
2003: Daniel J Rigden; Michael Galperin; Mark J Jedrzejas
Analysis of structure and function of putative surface-exposed proteins encoded in the Streptococcus pneumoniae genome: a bioinformatics-based approach to vaccine and drug design.
Critical reviews in biochemistry and molecular biology 2003;38(2):143-68.
2002: Daniel J Rigden; Peter Setlow; Barbara Setlow; Irina Bagyan; Richard A Stein; Mark J Jedrzejas
PrfA protein of Bacillus species: prediction and demonstration of endonuclease activity on DNA.
Protein science : a publication of the Protein Society 2002;11(10):2370-81.
2002: Luciane V Mello; Bert L de Groot; Songlin Li; Mark J Jedrzejas
Structure and flexibility of Streptococcus agalactiae hyaluronate lyase complex with its substrate. Insights into the mechanism of processive degradation of hyaluronan.
The Journal of biological chemistry 2002;277(39):36678-88.
2002: Mark J Jedrzejas; Luciane V Mello; Bert L de Groot; Songlin Li
Mechanism of hyaluronan degradation by Streptococcus pneumoniae hyaluronate lyase. Structures of complexes with the substrate.
The Journal of biological chemistry 2002;277(31):28287-97.
2002: Mark J Jedrzejas
Three-dimensional structure and molecular mechanism of novel enzymes of spore-forming bacteria.
Medical science monitor : international medical journal of experimental and clinical research 2002;8(8):RA183-90.
2002: Daniel J Rigden; Luciane V Mello; Peter Setlow; Mark J Jedrzejas
Structure and mechanism of action of a cofactor-dependent phosphoglycerate mutase homolog from Bacillus stearothermophilus with broad specificity phosphatase activity.
Journal of molecular biology 2002;315(5):1129-43.
2002: Mark J Jedrzejas
The structure and function of novel proteins of Bacillus anthracis and other spore-forming bacteria: development of novel prophylactic and therapeutic agents.
Critical reviews in biochemistry and molecular biology 2002;37(5):339-73.
2001: Songlin Li; Mark J Jedrzejas
Hyaluronan binding and degradation by Streptococcus agalactiae hyaluronate lyase.
The Journal of biological chemistry 2001;276(44):41407-16.
2001: Daniel J Rigden; Irina Bagyan; Ejvis Lamani; Peter Setlow; Mark J Jedrzejas
A cofactor-dependent phosphoglycerate mutase homolog from Bacillus stearothermophilus is actually a broad specificity phosphatase.
Protein science : a publication of the Protein Society 2001;10(9):1835-46.
2001: Mark J Jedrzejas; Ejvis Lamani; R S Becker
Characterization of selected strains of pneumococcal surface protein A.
The Journal of biological chemistry 2001;276(35):33121-8.
2001: Mark J Jedrzejas
Pneumococcal virulence factors: structure and function.
Microbiology and molecular biology reviews : MMBR 2001;65(2):187-207 ; first page, table of contents.
2001: Yancho Devedjiev; Jindrich Symersky; R Singh; Mark J Jedrzejas; Christie G Brouillette; Wayne J Brouillette; Donald D Muccio; Debasish Chattopadhyay; Lawrence J Delucas
Stabilization of active-site loops in NH3-dependent NAD+ synthetase from Bacillus subtilis.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 6):806-12.
2001: Songlin Li; Kenneth B Taylor; Stephen J Kelly; Mark J Jedrzejas
Vitamin C inhibits the enzymatic activity of Streptococcus pneumoniae hyaluronate lyase.
The Journal of biological chemistry 2001;276(18):15125-30.
2001: Stephen J Kelly; Kenneth B Taylor; Songlin Li; Mark J Jedrzejas
Kinetic properties of Streptococcus pneumoniae hyaluronate lyase.
Glycobiology 2001;11(4):297-304.
2001: Mark J Jedrzejas; Peter Setlow
Comparison of the binuclear metalloenzymes diphosphoglycerate-independent phosphoglycerate mutase and alkaline phosphatase: their mechanism of catalysis via a phosphoserine intermediate.
Chemical reviews 2001;101(3):607-18.
2000: Ejvis Lamani; David T McPherson; Susan Kay Hollingshead; Mark J Jedrzejas
Production, characterization, and crystallization of truncated forms of pneumococcal surface protein A from Escherichia coli.
Protein expression and purification 2000;20(3):379-88.
2000: Stephen J Kelly; Mark J Jedrzejas
Crystallization and preliminary X-ray diffraction analysis of a functional form of pneumolysin, a virulence factor from Streptococcus pneumoniae.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 11):1452-5.
2000: Stephen J Kelly; Mark J Jedrzejas
Structure and molecular mechanism of a functional form of pneumolysin: a cholesterol-dependent cytolysin from Streptococcus pneumoniae.
Journal of structural biology 2000;132(1):72-81.
2000: Stephen J Kelly; Richard A Stein; Irina Bagyan; Peter Setlow; Mark J Jedrzejas
Structural characterization of penicillin-binding protein-related factor A (PrfA) from Bacillus species.
Journal of structural biology 2000;131(2):90-5.
2000: Mark J Jedrzejas; Monica Chander; Peter Setlow; G Krishnasamy
Mechanism of catalysis of the cofactor-independent phosphoglycerate mutase from Bacillus stearothermophilus. Crystal structure of the complex with 2-phosphoglycerate.
The Journal of biological chemistry 2000;275(30):23146-53.
2000: Jun Xing; W Thomas Forsee; Ejvis Lamani; Sergei D Maltsev; Leonid L Danilov; Vladimir N Shibaev; John S Schutzbach; Herbert C Cheung; Mark J Jedrzejas
Investigations of the active site of Saccharomyces cerevisiae dolichyl-phosphate-mannose synthase using fluorescent labeled dolichyl-phosphate derivatives.
Biochemistry 2000;39(27):7886-94.
2000: Karthe Ponnuraj; S Rowland; C Nessi; Peter Setlow; Mark J Jedrzejas
Crystal structure of a novel germination protease from spores of Bacillus megaterium: structural arrangement and zymogen activation.
Journal of molecular biology 2000;300(1):1-10.
2000: Karthe Ponnuraj; Mark J Jedrzejas
Mechanism of hyaluronan binding and degradation: structure of Streptococcus pneumoniae hyaluronate lyase in complex with hyaluronic acid disaccharide at 1.7 A resolution.
Journal of molecular biology 2000;299(4):885-95.
2000: Mark J Jedrzejas; Monica Chander; Peter Setlow; G Krishnasamy
Structure and mechanism of action of a novel phosphoglycerate mutase from Bacillus stearothermophilus.
The EMBO journal 2000;19(7):1419-31.
2000: Mark J Jedrzejas; Laurent Chantalat
Structural studies of streptococcus agalactiae hyaluronate lyase.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 4):460-3.
2000: Songlin Li; Stephen J Kelly; Ejvis Lamani; M Ferraroni; Mark J Jedrzejas
Structural basis of hyaluronan degradation by Streptococcus pneumoniae hyaluronate lyase.
The EMBO journal 2000;19(6):1228-40.
2000: Vladimir N Shibaev; V V Veselovsky; A V Lozanova; Sergei D Maltsev; Leonid L Danilov; W Thomas Forsee; Jun Xing; Herbert C Cheung; Mark J Jedrzejas
Synthesis of dolichyl phosphate derivatives with fluorescent label at the omega-end of the chain, new tools to study protein glycosylation.
Bioorganic & medicinal chemistry letters 2000;10(2):189-92.
2000: Mark J Jedrzejas
Structure, function, and evolution of phosphoglycerate mutases: comparison with fructose-2,6-bisphosphatase, acid phosphatase, and alkaline phosphatase.
Progress in biophysics and molecular biology 2000;73(2-4):263-87.
2000: Mark J Jedrzejas
Structural and functional comparison of polysaccharide-degrading enzymes.
Critical reviews in biochemistry and molecular biology 2000;35(3):221-51.
2000: Karthe Ponnuraj; S Kelly; C Nessi; Peter Setlow; Mark J Jedrzejas
Crystallization and preliminary diffraction studies of a truncated form of a novel protease from spores of Bacillus megaterium.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 1):70-2.
2000: Mark J Jedrzejas; Susan Kay Hollingshead; J Lebowitz; Laurent Chantalat; D E Briles; Ejvis Lamani
Production and characterization of the functional fragment of pneumococcal surface protein A.
Archives of biochemistry and biophysics 2000;373(1):116-25.
1999: Monica Chander; Peter Setlow; Ejvis Lamani; Mark J Jedrzejas
Structural studies on a 2,3-diphosphoglycerate independent phosphoglycerate mutase from Bacillus stearothermophilus.
Journal of structural biology 1999;126(2):156-65.
1999: Karthe Ponnuraj; C Nessi; Peter Setlow; Mark J Jedrzejas
Structural studies of a novel germination protease from spores of Bacillus megaterium.
Journal of structural biology 1999;125(1):19-24.
1998: C Nessi; Mark J Jedrzejas; Peter Setlow
Structure and mechanism of action of the protease that degrades small, acid-soluble spore proteins during germination of spores of Bacillus species.
Journal of bacteriology 1998;180(19):5077-84.
1998: Mark J Jedrzejas; R Brandon Mewbourne; Laurent Chantalat; David T McPherson
Expression and purification of Streptococcus pneumoniae hyaluronate lyase from Escherichia coli.
Protein expression and purification 1998;13(1):83-9.
1998: Mark J Jedrzejas; Laurent Chantalat; R Brandon Mewbourne
Crystallization and preliminary X-ray analysis of Streptococcus pneumoniae hyaluronate lyase.
Journal of structural biology 1998;121(1):73-5.
1997: EA Sudbeck; Mark J Jedrzejas; S Singh; Wayne J Brouillette; Gillian M Air; W Graeme Laver; Yarlagadda S Babu; Shanta Bantia; Pooran Chand; N Chu; JA Montgomery; David A Walsh; Ming Luo
Guanidinobenzoic acid inhibitors of influenza virus neuraminidase.
Journal of molecular biology 1997;267(3):584-94.
1995: Mark J Jedrzejas; S Singh; Wayne J Brouillette; Gillian M Air; Ming Luo
A strategy for theoretical binding constant, Ki, calculations for neuraminidase aromatic inhibitors designed on the basis of the active site structure of influenza virus neuraminidase.
Proteins 1995;23(2):264-77.
1995: Mark J Jedrzejas; Ming Luo; S Singh; Wayne J Brouillette; Gillian M Air
4-(Acetylamino)-3-hydroxy-5-nitrobenzoic acid.
Acta crystallographica. Section C, Crystal structure communications 1995;51 ( Pt 9)():1910-2.
1995: S Singh; Mark J Jedrzejas; Gillian M Air; Ming Luo; W Graeme Laver; Wayne J Brouillette
Structure-based inhibitors of influenza virus sialidase. A benzoic acid lead with novel interaction.
Journal of medicinal chemistry 1995;38(17):3217-25.
1995: Ming Luo; Mark J Jedrzejas; S Singh; C L White; Wayne J Brouillette; Gillian M Air; W Graeme Laver
Benzoic acid inhibitors of influenza virus neuraminidase.
Acta crystallographica. Section D, Biological crystallography 1995;51(Pt 4):504-10.
1995: Mark J Jedrzejas; J Miglietta; J A Griffin; Ming Luo
Structure of a monoclonal anti-ICAM-1 antibody R6.5 Fab fragment at 2.8 A resolution.
Acta crystallographica. Section D, Biological crystallography 1995;51(Pt 3):380-5.
1995: Mark J Jedrzejas; J R Baker; Ming Luo
Crystallization and preliminary X-ray diffraction studies of the cartilage link protein from bovine trachea.
Proteins 1995;22(1):76-8.
1995: Mark J Jedrzejas; S Singh; Wayne J Brouillette; W Graeme Laver; Gillian M Air; Ming Luo
Structures of aromatic inhibitors of influenza virus neuraminidase.
Biochemistry 1995;34(10):3144-51.