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Colin Jefcoate

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Wenchao Zheng; Jinwoo Lee; Xueqing Liu; Craig Marcus; Tiegang Tong; Colin R Jefcoate
Stimulation of mouse Cyp1b1 during adipogenesis: characterization of promoter activation by the transcription factor Pax6.
Colin R Jefcoate; Jinwoo Lee; Nadia Cherradi; Hiroshi Takemori; Haichuan Duan
cAMP stimulation of StAR expression and cholesterol metabolism is modulated by co-expression of labile suppressors of transcription and mRNA turnover.
Alhaji U N'jai; Michele Campaigne Larsen; Justin R Bushkofsky; Charles J Czuprynski; Colin R Jefcoate
Acute disruption of bone marrow hematopoiesis by benzo(a)pyrene is selectively reversed by aryl hydrocarbon receptor-mediated processes.

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All Publications

2013: Wenchao Zheng; Jinwoo Lee; Xueqing Liu; Craig Marcus; Tiegang Tong; Colin R Jefcoate
Stimulation of mouse Cyp1b1 during adipogenesis: characterization of promoter activation by the transcription factor Pax6.
Archives of biochemistry and biophysics 2013;532(1):1-14.
2011: Colin R Jefcoate; Jinwoo Lee; Nadia Cherradi; Hiroshi Takemori; Haichuan Duan
cAMP stimulation of StAR expression and cholesterol metabolism is modulated by co-expression of labile suppressors of transcription and mRNA turnover.
Molecular and cellular endocrinology 2011;336(1-2):53-62.
2011: Alhaji U N'jai; Michele Campaigne Larsen; Justin R Bushkofsky; Charles J Czuprynski; Colin R Jefcoate
Acute disruption of bone marrow hematopoiesis by benzo(a)pyrene is selectively reversed by aryl hydrocarbon receptor-mediated processes.
Molecular pharmacology 2011;79(4):724-34.
2010: A U N'jai; M Larsen; L Shi; Colin R Jefcoate; Charles J Czuprynski
Bone marrow lymphoid and myeloid progenitor cells are suppressed in 7,12-dimethylbenz(a)anthracene (DMBA) treated mice.
Toxicology 2010;271(1-2):27-35.
2010: Yixin Tang; Elizabeth A Scheef; Zafer Gurel; Christine M Sorenson; Colin R Jefcoate; Nader Sheibani
CYP1B1 and endothelial nitric oxide synthase combine to sustain proangiogenic functions of endothelial cells under hyperoxic stress.
American journal of physiology. Cell physiology 2010;298(3):C665-78.
2009: Yixin Tang; Elizabeth A Scheef; Shoujian Wang; Christine M Sorenson; Craig B Marcus; Colin R Jefcoate; Nader Sheibani
CYP1B1 expression promotes the proangiogenic phenotype of endothelium through decreased intracellular oxidative stress and thrombospondin-2 expression.
Blood 2009;113(3):744-54.
2008: Richard B Halberg; Michele Campaigne Larsen; Tammy L Elmergreen; Alex Y Ko; Amy Irving; Linda Clipson; Colin R Jefcoate
Cyp1b1 exerts opposing effects on intestinal tumorigenesis via exogenous and endogenous substrates.
Cancer research 2008;68(18):7394-402.
2008: Colin R Jefcoate; Suqing Wang; Xueqing Liu
Methods that resolve different contributions of clonal expansion to adipogenesis in 3T3-L1 and C3H10T1/2 cells.
Methods in molecular biology (Clifton, N.J.) 2008;456():173-93.
2007: Haichuan Duan; Colin R Jefcoate
The predominant cAMP-stimulated 3 x 5 kb StAR mRNA contains specific sequence elements in the extended 3'UTR that confer high basal instability.
Journal of molecular endocrinology 2007;38(1-2):159-79.
2006: Xueqing Liu; Colin R Jefcoate
2,3,7,8-tetrachlorodibenzo-p-dioxin and epidermal growth factor cooperatively suppress peroxisome proliferator-activated receptor-gamma1 stimulation and restore focal adhesion complexes during adipogenesis: selective contributions of Src, Rho, and Erk distinguish these overlapping processes in C3H10T1/2 cells.
Molecular pharmacology 2006;70(6):1902-15.
2006: Takeshi Yamazaki; Chisa Matsuoka; Miho Gendou; Shunsuke Izumi; Dong Zhao; Irina Artemenko; Colin R Jefcoate; Shiro Kominami
Mitochondrial processing of bovine adrenal steroidogenic acute regulatory protein.
Biochimica et biophysica acta 2006;1764(10):1561-7.
2006: Colin R Jefcoate
Liver X receptor opens a new gateway to StAR and to steroid hormones.
The Journal of clinical investigation 2006;116(7):1832-5.
2006: Noé Galván; Todd Page; Charles J Czuprynski; Colin R Jefcoate
Benzo(a)pyrene and 7,12-dimethylbenz(a)anthrecene differentially affect bone marrow cells of the lymphoid and myeloid lineages.
Toxicology and applied pharmacology 2006;213(2):105-16.
2006: Yuki Tsuchiya; Miki Nakajima; Shingo Takagi; Miki Katoh; Wenchao Zheng; Colin R Jefcoate; Tsuyoshi Yokoi
Binding of steroidogenic factor-1 to the regulatory region might not be critical for transcriptional regulation of the human CYP1B1 gene.
Journal of biochemistry 2006;139(3):527-34.
2005: Paul Hanlon; Melissa A Cimafranca; Xueqing Liu; Young C Cho; Colin R Jefcoate
Microarray analysis of early adipogenesis in C3H10T1/2 cells: cooperative inhibitory effects of growth factors and 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Toxicology and applied pharmacology 2005;207(1):39-58.
2005: Young C Cho; Wenchao Zheng; Megumi Yamamoto; Xiequing Liu; Paul Hanlon; Colin R Jefcoate
Differentiation of pluripotent C3H10T1/2 cells rapidly elevates CYP1B1 through a novel process that overcomes a loss of Ah Receptor.
Archives of biochemistry and biophysics 2005;439(2):139-53.
2005: Dong Zhao; Haichuan Duan; Young-Cheul Kim; Colin R Jefcoate
Rodent StAR mRNA is substantially regulated by control of mRNA stability through sites in the 3'-untranslated region and through coupling to ongoing transcription.
The Journal of steroid biochemistry and molecular biology 2005;96(2):155-73.
2005: Alice S Yuroff; Colin R Jefcoate; Charles J Czuprynski
Close proximity, but not VLA-4-dependent adherence between pre-B cells and bone marrow stromal cells, is required for DMBA-induced apoptosis of pre-B cells in vitro.
Toxicology letters 2005;156(2):253-60.
2005: Dong Zhao; Hongwei Xue; Irina Artemenko; Colin R Jefcoate
Novel signaling stimulated by arsenite increases cholesterol metabolism through increases in unphosphorylated steroidogenic acute regulatory (StAR) protein.
Molecular and cellular endocrinology 2005;231(1-2):95-107.
2005: Noé Galván; Doug E Teske; Guodong Zhou; Bhagavatula Moorthy; Peter S MacWilliams; Charles J Czuprynski; Colin R Jefcoate
Induction of CYP1A1 and CYP1B1 in liver and lung by benzo(a)pyrene and 7,12-d imethylbenz(a)anthracene do not affect distribution of polycyclic hydrocarbons to target tissue: role of AhR and CYP1B1 in bone marrow cytotoxicity.
Toxicology and applied pharmacology 2005;202(3):244-57.
2005: Paul Hanlon; Wenchao Zheng; Alex Y Ko; Colin R Jefcoate
Identification of novel TCDD-regulated genes by microarray analysis.
Toxicology and applied pharmacology 2005;202(3):215-28.
2005: Wenchao Zheng; Colin R Jefcoate
Steroidogenic factor-1 interacts with cAMP response element-binding protein to mediate cAMP stimulation of CYP1B1 via a far upstream enhancer.
Molecular pharmacology 2005;67(2):499-512.
2004: Heather Elizabeth Kleiner-Hancock; Suryanarayana V Vulimiri; William B Hatten; Melissa J Reed; Daniel W Nebert; Colin R Jefcoate; John DiGiovanni
Role of cytochrome p4501 family members in the metabolic activation of polycyclic aromatic hydrocarbons in mouse epidermis.
Chemical research in toxicology 2004;17(12):1667-74.
2004: Haichuan Duan; Colin R Jefcoate
Effective StAR expression in mouse MA-10 and Y-1 cells: extensive overexpression does not increase basal or cAMP-induced steroidogenesis.
Endocrine research 2004;30(4):769.
2004: Irina Artemenko; Colin R Jefcoate
Multiple contributions from long-chain fatty acid metabolism in Y-1 and MA-10 cells.
Endocrine research 2004;30(4):637.
2004: Michele Campaigne Larsen; Paul B Brake; Richard Pollenz; Colin R Jefcoate
Linked expression of Ah receptor, ARNT, CYP1A1, and CYP1B1 in rat mammary epithelia, in vitro, is each substantially elevated by specific extracellular matrix interactions that precede branching morphogenesis.
Toxicological sciences : an official journal of the Society of Toxicology 2004;82(1):46-61.
2004: Young C Cho; Wenchao Zheng; Colin R Jefcoate
Disruption of cell-cell contact maximally but transiently activates AhR-mediated transcription in 10T1/2 fibroblasts.
Toxicology and applied pharmacology 2004;199(3):220-38.
2004: Todd Page; Peter S MacWilliams; Marulasiddappa Suresh; Colin R Jefcoate; Charles J Czuprynski
7-12 Dimethylbenz[a]anthracene-induced bone marrow hypocellularity is dependent on signaling through both the TNFR and PKR.
Toxicology and applied pharmacology 2004;198(1):21-8.
2004: Melissa A Cimafranca; Paul Hanlon; Colin R Jefcoate
TCDD administration after the pro-adipogenic differentiation stimulus inhibits PPARgamma through a MEK-dependent process but less effectively suppresses adipogenesis.
Toxicology and applied pharmacology 2004;196(1):156-68.
2004: Young C Cho; Colin R Jefcoate
PPARgamma1 synthesis and adipogenesis in C3H10T1/2 cells depends on S-phase progression, but does not require mitotic clonal expansion.
Journal of cellular biochemistry 2004;91(2):336-53.
2003: Noé Galván; Renata Jaskula-Sztul; Peter S MacWilliams; Charles J Czuprynski; Colin R Jefcoate
Bone marrow cytotoxicity of benzo[a]pyrene is dependent on CYP1B1 but is diminished by Ah receptor-mediated induction of CYP1A1 in liver.
Toxicology and applied pharmacology 2003;193(1):84-96.
2003: Leying Zhang; Wenchao Zheng; Colin R Jefcoate
Ah receptor regulation of mouse Cyp1B1 is additionally modulated by a second novel complex that forms at two AhR response elements.
Toxicology and applied pharmacology 2003;192(2):174-90.
2003: Wenchao Zheng; Paul B Brake; Kalyan K Bhattacharyya; Leying Zhang; Dong Zhao; Colin R Jefcoate
Cell selective cAMP induction of rat CYP1B1 in adrenal and testis cells. Identification of a novel cAMP-responsive far upstream enhancer and a second Ah receptor-dependent mechanism.
Archives of biochemistry and biophysics 2003;416(1):53-67.
2003: Todd Page; Scott OBrien; Karrie Holston; Peter S MacWilliams; Colin R Jefcoate; Charles J Czuprynski
7,12-Dimethylbenz[a]anthracene-induced bone marrow toxicity is p53-dependent.
Toxicological sciences : an official journal of the Society of Toxicology 2003;74(1):85-92.
2003: Paul Hanlon; Leonardo G Ganem; Young C Cho; Megumi Yamamoto; Colin R Jefcoate
AhR- and ERK-dependent pathways function synergistically to mediate 2,3,7,8-tetrachlorodibenzo-p-dioxin suppression of peroxisome proliferator-activated receptor-gamma1 expression and subsequent adipocyte differentiation.
Toxicology and applied pharmacology 2003;189(1):11-27.
2002: Colin R Jefcoate
High-flux mitochondrial cholesterol trafficking, a specialized function of the adrenal cortex.
The Journal of clinical investigation 2002;110(7):881-90.
2002: Todd Page; Scott OBrien; Colin R Jefcoate; Charles J Czuprynski
7,12-Dimethylbenz[a]anthracene induces apoptosis in murine pre-B cells through a caspase-8-dependent pathway.
Molecular pharmacology 2002;62(2):313-9.
2001: Irina Artemenko; Dong Zhao; Dale Buchanan Hales; Karen Held Hales; Colin R Jefcoate
Mitochondrial processing of newly synthesized steroidogenic acute regulatory protein (StAR), but not total StAR, mediates cholesterol transfer to cytochrome P450 side chain cleavage enzyme in adrenal cells.
The Journal of biological chemistry 2001;276(49):46583-96.
2000: WG Angus; M Campaigne Larsen; Colin R Jefcoate
TCDD elevates erbB2 expression and signaling in T47D cells by reversing serum potentiation of estrogen receptor activity, independent of estrogen levels and enhanced ER down-regulation.
Molecular and cellular endocrinology 2000;170(1-2):1-13.
2000: Colin R Jefcoate; Irina Artemenko; Dong Zhao
Relationship of StAR expression to mitochondrial cholesterol transfer and metabolism.
Endocrine research 2000;26(4):663-80.
2000: SM Heidel; Peter S MacWilliams; William M Baird; Wan-Mohaiza Dashwood; Jeroen Buters; F J Gonzalez; Michele Campaigne Larsen; Charles J Czuprynski; Colin R Jefcoate
Cytochrome P4501B1 mediates induction of bone marrow cytotoxicity and preleukemia cells in mice treated with 7,12-dimethylbenz[a]anthracene.
Cancer research 2000;60(13):3454-60.
1999: David L Alexander; Leying Zhang; Mahtab B Foroozesh; William L Alworth; Colin R Jefcoate
Metabolism-based polycyclic aromatic acetylene inhibition of CYP1B1 in 10T1/2 cells potentiates aryl hydrocarbon receptor activity.
Toxicology and applied pharmacology 1999;161(2):123-39.
1999: SM Heidel; K Holston; Jeroen Buters; F J Gonzalez; Colin R Jefcoate; C J Czupyrynski
Bone marrow stromal cell cytochrome P4501B1 is required for pre-B cell apoptosis induced by 7,12-dimethylbenz[a]anthracene.
Molecular pharmacology 1999;56(6):1317-23.
1999: F I Ikegwuonu; Colin R Jefcoate
Evidence for the involvement of the fatty acid and peroxisomal beta-oxidation pathways in the inhibition by dehydroepiandrosterone (DHEA) and induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and benz(a)anthracene (BA) of cytochrome P4501B1 (CYP1B1) in mouse embryo fibroblasts (C3H10T1/2 cells).
Molecular and cellular biochemistry 1999;198(1-2):89-100.
1999: WG Angus; Michele Campaigne Larsen; Colin R Jefcoate
Expression of CYP1A1 and CYP1B1 depends on cell-specific factors in human breast cancer cell lines: role of estrogen receptor status.
Carcinogenesis 1999;20(6):947-55.
1999: Paul B Brake; M Arai; S As-Sanie; Colin R Jefcoate; E P Widmaier
Developmental expression and regulation of adrenocortical cytochrome P4501B1 in the rat.
Endocrinology 1999;140(4):1672-80.
1999: F I Ikegwuonu; M Christou; Colin R Jefcoate
Regulation of cytochrome P4501B1 (CYP1B1) in mouse embryo fibroblast (C3H10T1/2) cells by protein kinase C (PKC).
Biochemical pharmacology 1999;57(6):619-30.
1999: Jeroen Buters; S Sakai; T Richter; T Pineau; David L Alexander; U Savas; Johannes Doehmer; Jerrold M Ward; Colin R Jefcoate; Frank J Gonzalez
Cytochrome P450 CYP1B1 determines susceptibility to 7, 12-dimethylbenz[a]anthracene-induced lymphomas.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):1977-82.
1999: Sakina E Eltom; Leying Zhang; Colin R Jefcoate
Regulation of cytochrome P-450 (CYP) 1B1 in mouse Hepa-1 variant cell lines: A possible role for aryl hydrocarbon receptor nuclear translocator (ARNT) as a suppressor of CYP1B1 gene expression.
Molecular pharmacology 1999;55(3):594-604.
1999: Leonardo G Ganem; E Trottier; A Anderson; Colin R Jefcoate
Phenobarbital induction of CYP2B1/2 in primary hepatocytes: endocrine regulation and evidence for a single pathway for multiple inducers.
Toxicology and applied pharmacology 1999;155(1):32-42.
1998: SM Heidel; Charles J Czuprynski; Colin R Jefcoate
Bone marrow stromal cells constitutively express high levels of cytochrome P4501B1 that metabolize 7,12-dimethylbenz[a]anthracene.
Molecular pharmacology 1998;54(6):1000-6.
1998: Paul B Brake; Leying Zhang; Colin R Jefcoate
Aryl hydrocarbon receptor regulation of cytochrome P4501B1 in rat mammary fibroblasts: evidence for transcriptional repression by glucocorticoids.
Molecular pharmacology 1998;54(5):825-33.
1998: David L Alexander; Leonardo G Ganem; P Fernandez-Salguero; F Gonzalez; Colin R Jefcoate
Aryl-hydrocarbon receptor is an inhibitory regulator of lipid synthesis and of commitment to adipogenesis.
Journal of cell science 1998;111 ( Pt 22)():3311-22.
1998: Sakina E Eltom; Michele Campaigne Larsen; Colin R Jefcoate
Expression of CYP1B1 but not CYP1A1 by primary cultured human mammary stromal fibroblasts constitutively and in response to dioxin exposure: role of the Ah receptor.
Carcinogenesis 1998;19(8):1437-44.
1998: Andreas Luch; Stephanie L Coffing; Y M Tang; A Schneider; Volker J Soballa; Helmut Greim; Colin R Jefcoate; Albrecht Seidel; William F Greenlee; William M Baird; Johannes Doehmer
Stable expression of human cytochrome P450 1B1 in V79 Chinese hamster cells and metabolically catalyzed DNA adduct formation of dibenzo[a,l]pyrene.
Chemical research in toxicology 1998;11(6):686-95.
1998: Michele Campaigne Larsen; WG Angus; Paul B Brake; Sakina E Eltom; K A Sukow; Colin R Jefcoate
Characterization of CYP1B1 and CYP1A1 expression in human mammary epithelial cells: role of the aryl hydrocarbon receptor in polycyclic aromatic hydrocarbon metabolism.
Cancer research 1998;58(11):2366-74.
1998: Leonardo G Ganem; Colin R Jefcoate
Endocrine factors modulate the phenobarbital-mediated induction of cytochromes P450 and phase II enzymes in a similar strain-dependent manner.
Toxicology and applied pharmacology 1998;150(1):68-75.
1998: N Ariyoshi; Y C Kim; Irina Artemenko; Kalyan K Bhattacharyya; Colin R Jefcoate
Characterization of the rat Star gene that encodes the predominant 3.5-kilobase pair mRNA. ACTH stimulation of adrenal steroids in vivo precedes elevation of Star mRNA and protein.
The Journal of biological chemistry 1998;273(13):7610-9.
1998: Leying Zhang; U Savas; David L Alexander; Colin R Jefcoate
Characterization of the mouse Cyp1B1 gene. Identification of an enhancer region that directs aryl hydrocarbon receptor-mediated constitutive and induced expression.
The Journal of biological chemistry 1998;273(9):5174-83.
1997: U Savas; C P Carstens; Colin R Jefcoate
Biological oxidations and P450 reactions. Recombinant mouse CYP1B1 expressed in Escherichia coli exhibits selective binding by polycyclic hydrocarbons and metabolism which parallels C3H10T1/2 cell microsomes, but differs from human recombinant CYP1B1.
Archives of biochemistry and biophysics 1997;347(2):181-92.
1997: David L Alexander; Sakina E Eltom; Colin R Jefcoate
Ah receptor regulation of CYP1B1 expression in primary mouse embryo-derived cells.
Cancer research 1997;57(20):4498-506.
1997: Mary E Elliott; Theodore L Goodfriend; Dennis L Ball; Colin R Jefcoate
Angiotensin-responsive adrenal glomerulosa cell proteins: characterization by protease mapping, species comparison, and specific angiotensin receptor antagonists.
Endocrinology 1997;138(6):2530-6.
1997: H J Einolf; W T Story; Craig B Marcus; Michele Campaigne Larsen; Colin R Jefcoate; William F Greenlee; H Yagi; D M Jerina; S Amin; S S Park; H V Gelboin; William M Baird
Role of cytochrome P450 enzyme induction in the metabolic activation of benzo[c]phenanthrene in human cell lines and mouse epidermis.
Chemical research in toxicology 1997;10(5):609-17.
1997: MJ Santostefano; DG Ross; U Savas; Colin R Jefcoate; Linda S Birnbaum
Differential time-course and dose-response relationships of TCDD-induced CYP1B1, CYP1A1, and CYP1A2 proteins in rats.
Biochemical and biophysical research communications 1997;233(1):20-4.
1997: Y C Kim; N Ariyoshi; Irina Artemenko; Mary E Elliott; Kalyan K Bhattacharyya; Colin R Jefcoate
Control of cholesterol access to cytochrome P450scc in rat adrenal cells mediated by regulation of the steroidogenic acute regulatory protein.
Steroids 1997;62(1):10-20.
1996: R C Bowes; A R Parrish; M A Steinberg; Kristine L Willett; W Zhao; U Savas; Colin R Jefcoate; Stephen H Safe; Kenneth S Ramos
Atypical cytochrome P450 induction profiles in glomerular mesangial cells at the mRNA and enzyme level. Evidence for CYP1A1 and CYP1B1 expression and their involvement in benzo[a]pyrene metabolism.
Biochemical pharmacology 1996;52(4):587-95.
1996: F I Ikegwuonu; Leonardo G Ganem; M C Larson; X Shen; Colin R Jefcoate
The regulation by gender, strain, dose, and feeding status of the induction of multiple forms of cytochrome P450 isozymes in rat hepatic microsomes by 2,4,5,2',4',5'-hexachlorobiphenyl.
Toxicology and applied pharmacology 1996;139(1):33-41.
1995: M Christou; U Savas; S Schroeder; X Shen; T Thompson; M N Gould; Colin R Jefcoate
Cytochromes CYP1A1 and CYP1B1 in the rat mammary gland: cell-specific expression and regulation by polycyclic aromatic hydrocarbons and hormones.
Molecular and cellular endocrinology 1995;115(1):41-50.
1995: K Connor; Stephen Safe; Colin R Jefcoate; M Larsen
Structure-dependent induction of CYP2B by polychlorinated biphenyl congeners in female Sprague-Dawley rats.
Biochemical pharmacology 1995;50(11):1913-20.
1995: Paul B Brake; Colin R Jefcoate
Regulation of cytochrome P4501B1 in cultured rat adrenocortical cells by cyclic adenosine 3',5'-monophosphate and 2,3,7,8- tetrachlorodibenzo-p-dioxin.
Endocrinology 1995;136(11):5034-41.
1995: Michele Campaigne Larsen; Colin R Jefcoate
Phenobarbital induction of CYP2B1, CYP2B2, and CYP3A1 in rat liver: genetic differences in a common regulatory mechanism.
Archives of biochemistry and biophysics 1995;321(2):467-76.
1995: K K Bhattacharyya; Paul B Brake; Sakina E Eltom; S A Otto; Colin R Jefcoate
Identification of a rat adrenal cytochrome P450 active in polycyclic hydrocarbon metabolism as rat CYP1B1. Demonstration of a unique tissue-specific pattern of hormonal and aryl hydrocarbon receptor-linked regulation.
The Journal of biological chemistry 1995;270(19):11595-602.
1995: E F Nuwaysir; Yvonne P Dragan; Colin R Jefcoate; V C Jordan; Henry C Pitot
Effects of tamoxifen administration on the expression of xenobiotic metabolizing enzymes in rat liver.
Cancer research 1995;55(8):1780-6.
1995: T Yamazaki; Renu A Kowluru; B C McNamara; Colin R Jefcoate
P450scc-dependent cholesterol metabolism in rat adrenal mitochondria is inhibited by low concentrations of matrix Ca2+.
Archives of biochemistry and biophysics 1995;318(1):131-9.
1995: Renu A Kowluru; T Yamazaki; B C McNamara; Colin R Jefcoate
Metabolism of exogenous cholesterol by rat adrenal mitochondria is stimulated equally by physiological levels of free Ca2+ and by GTP.
Molecular and cellular endocrinology 1995;107(2):181-8.
1994: David C Spink; CL Hayes; N R Young; M Christou; Thomas R Sutter; Colin R Jefcoate; John F Gierthy
The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on estrogen metabolism in MCF-7 breast cancer cells: evidence for induction of a novel 17 beta-estradiol 4-hydroxylase.
The Journal of steroid biochemistry and molecular biology 1994;51(5-6):251-8.
1994: Michele Campaigne Larsen; Paul B Brake; D Parmar; Colin R Jefcoate
The induction of five rat hepatic P450 cytochromes by phenobarbital and similarly acting compounds is regulated by a sexually dimorphic, dietary-dependent endocrine factor that is highly strain specific.
Archives of biochemistry and biophysics 1994;315(1):24-34.
1994: U Savas; Colin R Jefcoate
Dual regulation of cytochrome P450EF expression via the aryl hydrocarbon receptor and protein stabilization in C3H/10T1/2 cells.
Molecular pharmacology 1994;45(6):1153-9.
1994: U Savas; K K Bhattacharyya; M Christou; David L Alexander; Colin R Jefcoate
Mouse cytochrome P-450EF, representative of a new 1B subfamily of cytochrome P-450s. Cloning, sequence determination, and tissue expression.
The Journal of biological chemistry 1994;269(21):14905-11.
1994: M Christou; U Savas; David C Spink; John F Gierthy; Colin R Jefcoate
Co-expression of human CYP1A1 and a human analog of cytochrome P450-EF in response to 2,3,7,8-tetrachloro-dibenzo-p-dioxin in the human mammary carcinoma-derived MCF-7 cells.
Carcinogenesis 1994;15(4):725-32.
1993: U Savas; M Christou; Colin R Jefcoate
Mouse endometrium stromal cells express a polycyclic aromatic hydrocarbon-inducible cytochrome P450 that closely resembles the novel P450 in mouse embryo fibroblasts (P450EF).
Carcinogenesis 1993;14(10):2013-8.
1993: T Yamazaki; B C McNamara; Colin R Jefcoate
Competition for electron transfer between cytochromes P450scc and P45011 beta in rat adrenal mitochondria.
Molecular and cellular endocrinology 1993;95(1-2):1-11.
1993: M Christou; I M Keith; X Shen; M E Schroeder; Colin R Jefcoate
Reversal of cytochrome P-4501A1 and P-450-EF expression in MCA-C3H/10T1/2 cell-derived tumors as compared to cultured cells.
Cancer research 1993;53(5):968-76.
1992: S Otto; K K Bhattacharyya; Colin R Jefcoate
Polycyclic aromatic hydrocarbon metabolism in rat adrenal, ovary, and testis microsomes is catalyzed by the same novel cytochrome P450 (P450RAP).
Endocrinology 1992;131(6):3067-76.
1992: M Christou; M J Mitchell; T Aoyama; H V Gelboin; F J Gonzalez; Colin R Jefcoate
Selective suppression of the catalytic activity of cDNA-expressed cytochrome P4502B1 toward polycyclic hydrocarbons in the microsomal membrane: modification of this effect by specific amino acid substitutions.
Biochemistry 1992;31(10):2835-41.
1991: T H Maltzman; M Christou; Michael N Gould; Colin R Jefcoate
Effects of monoterpenoids on in vivo DMBA-DNA adduct formation and on phase I hepatic metabolizing enzymes.
Carcinogenesis 1991;12(11):2081-7.
1991: S Otto; Craig B Marcus; C Pidgeon; Colin R Jefcoate
A novel adrenocorticotropin-inducible cytochrome P450 from rat adrenal microsomes catalyzes polycyclic aromatic hydrocarbon metabolism.
Endocrinology 1991;129(2):970-82.
1991: M S Dhariwal; Renu A Kowluru; Colin R Jefcoate
Cytochrome P-450scc induces vesicle aggregation through a secondary interaction at the adrenodoxin binding sites (in competition with protein exchange.
Biochemistry 1991;30(20):4940-9.
1991: L H Pottenger; M Christou; Colin R Jefcoate
Purification and immunological characterization of a novel cytochrome P450 from C3H/10T1/2 cells.
Archives of biochemistry and biophysics 1991;286(2):488-97.
1991: B C McNamara; Colin R Jefcoate
Succinate stimulation of isocitrate supported deoxycorticosterone metabolism in rat adrenal mitochondria by a synergistic mechanism.
Endocrine research 1991;17(1-2):185-93.
1990: B C McNamara; Colin R Jefcoate
Heterogeneous pools of cholesterol side-chain cleavage activity in adrenal mitochondria from adrenocorticotropic hormone-treated rats: reconstitution of the isocitrate response with succinate and low concentrations of isocitrate.
Archives of biochemistry and biophysics 1990;283(2):464-71.
1990: B C McNamara; Colin R Jefcoate
Heterogeneous pools of cholesterol side-chain cleavage activity in adrenal mitochondria from ACTH-treated rats: differential responses to different reducing precursors.
Molecular and cellular endocrinology 1990;73(2-3):123-34.
1990: M Christou; P Stewart; L H Pottenger; W E Fahl; Colin R Jefcoate
Differences in the modulation of P450IA1 and epoxide hydratase expression by benz[a]anthracene and 2,3,7,8-tetrachlorodibenzo-p-dioxin in mouse embryo versus mouse hepatoma-derived cell lines.
Carcinogenesis 1990;11(10):1691-8.
1990: L H Pottenger; Colin R Jefcoate
Characterization of a novel cytochrome P450 from the transformable cell line, C3H/10T1/2.
Carcinogenesis 1990;11(2):321-7.
1989: B C McNamara; Colin R Jefcoate
The role of sterol carrier protein 2 in stimulation of steroidogenesis in rat adrenal mitochondria by adrenal cytosol.
Archives of biochemistry and biophysics 1989;275(1):53-62.
1989: M S Dhariwal; Colin R Jefcoate
Cholesterol metabolism by purified cytochrome P-450scc is highly stimulated by octyl glucoside and stearic acid exclusively in large unilamellar phospholipid vesicles.
Biochemistry 1989;28(21):8397-402.
1989: M Christou; M C Jovanovich; Colin R Jefcoate
Epoxide hydratase: sex specific expression and rate-limiting role in DMBA metabolism.
Carcinogenesis 1989;10(10):1883-90.
1989: M Christou; M J Mitchell; M C Jovanovich; N M Wilson; Colin R Jefcoate
Selective potent restriction of P450b- but not P450e-dependent 7,12-dimethylbenz[a]anthracene metabolism by the microsomal environment.
Archives of biochemistry and biophysics 1989;270(1):162-72.
1988: B C McNamara; Colin R Jefcoate
Synergistic stimulation of pregnenolone synthesis in rat adrenal mitochondria by n-hexane and cardiolipin.
Archives of biochemistry and biophysics 1988;260(2):780-8.
1987: M Christou; N M Wilson; Colin R Jefcoate
Expression and function of three cytochrome P-450 isozymes in rat extrahepatic tissues.
Archives of biochemistry and biophysics 1987;258(2):519-34.
1987: C T Privalle; B C McNamara; M S Dhariwal; Colin R Jefcoate
ACTH control of cholesterol side-chain cleavage at adrenal mitochondrial cytochrome P-450scc. Regulation of intramitochondrial cholesterol transfer.
Molecular and cellular endocrinology 1987;53(1-2):87-101.
1987: N M Wilson; M Christou; Colin R Jefcoate
Differential expression and function of three closely related phenobarbital-inducible cytochrome P-450 isozymes in untreated rat liver.
Archives of biochemistry and biophysics 1987;256(2):407-20.
1987: G M Keller; M Christou; L H Pottenger; N M Wilson; Colin R Jefcoate
Product inhibition of benzo[a]pyrene metabolism in uninduced rat liver microsomes: effect of diol epoxide formation.
Chemico-biological interactions 1987;61(2):159-75.
1987: M J DiBartolomeis; R W Moore; R E Peterson; B J Christian; Colin R Jefcoate
Altered regulation of adrenal steroidogenesis in 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated rats.
Biochemical pharmacology 1987;36(1):59-67.
1987: Colin R Jefcoate; M J DiBartolomeis; C A Williams; B C McNamara
ACTH regulation of cholesterol movement in isolated adrenal cells.
Journal of steroid biochemistry 1987;27(4-6):721-9.
1986: M J DiBartolomeis; R W Moore; R E Peterson; Colin R Jefcoate
Hypercholesterolemia and the regulation of adrenal steroidogenesis in 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated rats.
Toxicology and applied pharmacology 1986;85(3):313-23.
1986: M J DiBartolomeis; C Williams; Colin R Jefcoate
Inhibition of ACTH action on cultured bovine adrenal cortical cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin through a redistribution of cholesterol.
The Journal of biological chemistry 1986;261(10):4432-7.
1986: M J Dibartolomeis; M Christou; Colin R Jefcoate
Regulation of rat and bovine adrenal metabolism of polycyclic aromatic hydrocarbons by adrenocorticotropin and 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Archives of biochemistry and biophysics 1986;246(1):428-38.
1986: Colin R Jefcoate; B C McNamara; M J DiBartolomeis
Control of steroid synthesis in adrenal fasciculata cells.
Endocrine research 1986;12(4):315-50.
1985: S Narasimhulu; C R Eddy; M Dibartolomeis; Renu A Kowluru; Colin R Jefcoate
Adrenal microsomal hydroxylating system: purification and substrate binding properties of cytochrome P-450C-21.
Biochemistry 1985;24(16):4287-94.
1984: G M Keller; Colin R Jefcoate
Benzo(a)pyrene activation to 7,8-dihydrodiol 9,10-oxide by rat liver microsomes. Control by selective product inhibition.
The Journal of biological chemistry 1984;259(22):13770-6.
1984: N M Wilson; M Christou; C R Turner; S A Wrighton; Colin R Jefcoate
Binding and metabolism of benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene by seven purified forms of cytochrome P-450.
Carcinogenesis 1984;5(11):1475-83.
1984: M Christou; N M Wilson; Colin R Jefcoate
The role of secondary metabolism in the metabolic activation of 7,12-dimethylbenz[a]anthracene by rat liver microsomes.
Carcinogenesis 1984;5(10):1239-47.
1984: M J DiBartolomeis; Colin R Jefcoate
Characterization of the acute stimulation of steroidogenesis in primary bovine adrenal cortical cell cultures.
The Journal of biological chemistry 1984;259(16):10159-67.
1984: M J Dibartolomeis; Colin R Jefcoate
The interrelationship of polycyclic hydrocarbon metabolism and steroidogenesis in primary cultures of bovine adrenal cortical cells.
Molecular pharmacology 1984;25(3):476-86.
1983: G M Keller; Colin R Jefcoate
Modulation of microsomal benzo[a]pyrene metabolism by DNA.
Molecular pharmacology 1983;23(3):735-42.
1983: C T Privalle; J F Crivello; Colin R Jefcoate
Regulation of intramitochondrial cholesterol transfer to side-chain cleavage cytochrome P-450 in rat adrenal gland.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(3):702-6.
1982: G M Keller; C R Turner; Colin R Jefcoate
Kinetic determinants of benzo[a]pyrene metabolism to dihydrodiol epoxides by 3-methylcholanthrene-induced rat liver microsomes.
Molecular pharmacology 1982;22(2):451-8.
1981: Israel Hanukoglu; V Spitsberg; J A Bumpus; K M Dus; Colin R Jefcoate
Adrenal mitochondrial cytochrome P-450scc. Cholesterol and adrenodoxin interactions at equilibrium and during turnover.
The Journal of biological chemistry 1981;256(9):4321-8.
1981: Israel Hanukoglu; C T Privalle; Colin R Jefcoate
Mechanisms of ionic activation of adrenal mitochondrial cytochromes P-450scc and P-45011 beta.
The Journal of biological chemistry 1981;256(9):4329-35.
1980: Israel Hanukoglu; Colin R Jefcoate
Mitochondrial cytochrome P-450scc. Mechanism of electron transport by adrenodoxin.
The Journal of biological chemistry 1980;255(7):3057-61.