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Leonard Jefferson

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Andrew R Kelleher; Scot R Kimball; Rudolf J Schilder; Michael D Dennis; Leonard S Jefferson
The mTORC1 signaling repressors REDD1/2 are rapidly induced and activation of p70S6K1 by leucine is defective in skeletal muscle of an immobilized rat hindlimb.
Michael D Dennis; Scot R Kimball; Leonard S Jefferson
Mechanistic target of rapamycin complex 1 (mTORC1)-mediated phosphorylation is governed by competition between substrates for interaction with raptor.
Michael D Dennis; Leonard S Jefferson; Scot R Kimball
Role of p70S6K1-mediated phosphorylation of eIF4B and PDCD4 proteins in the regulation of protein synthesis.

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2013: Andrew R Kelleher; Scot R Kimball; Rudolf J Schilder; Michael D Dennis; Leonard S Jefferson
The mTORC1 signaling repressors REDD1/2 are rapidly induced and activation of p70S6K1 by leucine is defective in skeletal muscle of an immobilized rat hindlimb.
American journal of physiology. Endocrinology and metabolism 2013;304(2):E229-36.
2013: Michael D Dennis; Scot R Kimball; Leonard S Jefferson
Mechanistic target of rapamycin complex 1 (mTORC1)-mediated phosphorylation is governed by competition between substrates for interaction with raptor.
The Journal of biological chemistry 2013;288(1):10-9.
2012: Michael D Dennis; Leonard S Jefferson; Scot R Kimball
Role of p70S6K1-mediated phosphorylation of eIF4B and PDCD4 proteins in the regulation of protein synthesis.
The Journal of biological chemistry 2012;287(51):42890-9.
2012: Scot R Kimball; Leonard S Jefferson
Induction of REDD1 gene expression in the liver in response to endoplasmic reticulum stress is mediated through a PERK, eIF2α phosphorylation, ATF4-dependent cascade.
Biochemical and biophysical research communications 2012;427(3):485-9.
2011: Michael D Dennis; Scot R Kimball; Tabitha L Schrufer; Sarah K Bronson; Leonard S Jefferson
Hyperglycemia-induced O-GlcNAcylation and truncation of 4E-BP1 protein in liver of a mouse model of type 1 diabetes.
The Journal of biological chemistry 2011;286(39):34286-97.
2011: Rashmi Kumari; Ian A Simpson; Lisa B Willing; Leonard S Jefferson; Scot R Kimball
REDD1 (regulated in development and DNA damage response 1) expression in skeletal muscle as a surrogate biomarker of the efficiency of glucocorticoid receptor blockade.
Biochemical and biophysical research communications 2011;412(4):644-7.
2011: Rudolf J Schilder; Scot R Kimball; James H Marden; Leonard S Jefferson
Body weight-dependent troponin T alternative splicing is evolutionarily conserved from insects to mammals and is partially impaired in skeletal muscle of obese rats.
The Journal of experimental biology 2011;214(Pt 9):1523-32.
2011: Jeremiah N Winter; Leonard S Jefferson; Scot R Kimball
ERK and Akt signaling pathways function through parallel mechanisms to promote mTORC1 signaling.
American journal of physiology. Cell physiology 2011;300(5):C1172-80.
2011: Michael D Dennis; Jamie I Baum; Scot R Kimball; Leonard S Jefferson
Mechanisms involved in the coordinate regulation of mTORC1 by insulin and amino acids.
The Journal of biological chemistry 2011;286(10):8287-96.
2011: Alexander P Tuckow; Sarah J Jefferson; Scot R Kimball; Leonard S Jefferson
Simvastatin represses protein synthesis in the muscle-derived C₂C₁₂ cell line with a concomitant reduction in eukaryotic initiation factor 2B expression.
American journal of physiology. Endocrinology and metabolism 2011;300(3):E564-70.
2010: Scot R Kimball; Leonard S Jefferson
Control of translation initiation through integration of signals generated by hormones, nutrients, and exercise.
The Journal of biological chemistry 2010;285(38):29027-32.
2010: Jia Li; Caroline Romestaing; Xianlin Han; Yuan Li; Xinbao Hao; Yinyuan Wu; Chao Sun; Xiaolei Liu; Leonard S Jefferson; Jingwei Xiong; Kathryn F Lanoue; Zhijie Chang; Christopher J Lynch; Huayan Wang; Yuguang Shi
Cardiolipin remodeling by ALCAT1 links oxidative stress and mitochondrial dysfunction to obesity.
Cell metabolism 2010;12(2):154-65.
2010: Alexander P Tuckow; Thomas C Vary; Scot R Kimball; Leonard S Jefferson
Ectopic expression of eIF2Bepsilon in rat skeletal muscle rescues the sepsis-induced reduction in guanine nucleotide exchange activity and protein synthesis.
American journal of physiology. Endocrinology and metabolism 2010;299(2):E241-8.
2010: Jeremiah N Winter; Todd E Fox; Mark Kester; Leonard S Jefferson; Scot R Kimball
Phosphatidic acid mediates activation of mTORC1 through the ERK signaling pathway.
American journal of physiology. Cell physiology 2010;299(2):C335-44.
2009: An N Dang Do; Scot R Kimball; Douglas R Cavener; Leonard S Jefferson
eIF2alpha kinases GCN2 and PERK modulate transcription and translation of distinct sets of mRNAs in mouse liver.
Physiological genomics 2009;38(3):328-41.
2009: Jamie I Baum; Scot R Kimball; Leonard S Jefferson
Glucagon acts in a dominant manner to repress insulin-induced mammalian target of rapamycin complex 1 signaling in perfused rat liver.
American journal of physiology. Endocrinology and metabolism 2009;297(2):E410-5.
2009: Lianqin Zhang; Scot R Kimball; Leonard S Jefferson; Jeffrey Shenberger
Hydrogen peroxide impairs insulin-stimulated assembly of mTORC1.
Free radical biology & medicine 2009;46(11):1500-9.
2009: Nora K McGhee; Leonard S Jefferson; Scot R Kimball
Elevated corticosterone associated with food deprivation upregulates expression in rat skeletal muscle of the mTORC1 repressor, REDD1.
The Journal of nutrition 2009;139(5):828-34.
2009: Michael L Whitney; Leonard S Jefferson; Scot R Kimball
ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression.
Biochemical and biophysical research communications 2009;379(2):451-5.
2008: James W Gallagher; Neil Kubica; Scot R Kimball; Leonard S Jefferson
Reduced eukaryotic initiation factor 2Bepsilon-subunit expression suppresses the transformed phenotype of cells overexpressing the protein.
Cancer research 2008;68(21):8752-60.
2008: Renan A Orellana; Agus Suryawan; Scot R Kimball; Guoyao Wu; Hanh V Nguyen; Leonard S Jefferson; Teresa A Davis
Insulin signaling in skeletal muscle and liver of neonatal pigs during endotoxemia.
Pediatric research 2008;64(5):505-10.
2008: Ali K Reiter; Douglas R Bolster; Stephen J Crozier; Scot R Kimball; Leonard S Jefferson
AMPK represses TOP mRNA translation but not global protein synthesis in liver.
Biochemical and biophysical research communications 2008;374(2):345-50.
2008: Scot R Kimball; Ahmed Abbas; Leonard S Jefferson
Melatonin represses oxidative stress-induced activation of the MAP kinase and mTOR signaling pathways in H4IIE hepatoma cells through inhibition of Ras.
Journal of pineal research 2008;44(4):379-86.
2008: Scot R Kimball; A N Dang Do; Lydia Kutzler; Douglas R Cavener; Leonard S Jefferson
Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis.
The Journal of biological chemistry 2008;283(6):3465-75.
2008: Neil Kubica; Jamie L Crispino; James W Gallagher; Scot R Kimball; Leonard S Jefferson
Activation of the mammalian target of rapamycin complex 1 is both necessary and sufficient to stimulate eukaryotic initiation factor 2Bvarepsilon mRNA translation and protein synthesis.
The international journal of biochemistry & cell biology 2008;40(11):2522-33.
2007: Andrea Manni; Terry Rager; Scot R Kimball; Leonard S Jefferson; Sharlene Washington; Xin Hu; Michael F Verderame
Effects of alpha-difluoromethylornithine on thrombospondin-1 production by human breast cancer cells.
International journal of oncology 2007;31(5):1187-91.
2007: Thomas C Vary; Joshua C Anthony; Leonard S Jefferson; Scot R Kimball; Christopher J Lynch
Rapamycin blunts nutrient stimulation of eIF4G, but not PKCepsilon phosphorylation, in skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2007;293(1):E188-96.
2007: Brian J Krawiec; Gerald J Nystrom; Robert A Frost; Leonard S Jefferson; Charles H Lang
AMP-activated protein kinase agonists increase mRNA content of the muscle-specific ubiquitin ligases MAFbx and MuRF1 in C2C12 cells.
American journal of physiology. Endocrinology and metabolism 2007;292(6):E1555-67.
2007: Hussam H Shaheen; Rick L Horetsky; Scot R Kimball; Athulaprabha Murthi; Leonard S Jefferson; Anita K Hopper
Retrograde nuclear accumulation of cytoplasmic tRNA in rat hepatoma cells in response to amino acid deprivation.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(21):8845-50.
2007: Renan A Orellana; Scot R Kimball; Agus Suryawan; Jeffery Escobar; Hanh V Nguyen; Leonard S Jefferson; Teresa A Davis
Insulin stimulates muscle protein synthesis in neonates during endotoxemia despite repression of translation initiation.
American journal of physiology. Endocrinology and metabolism 2007;292(2):E629-36.
2007: Ganesan Ramesh; Scot R Kimball; Leonard S Jefferson; W Brian Reeves
Endotoxin and cisplatin synergistically stimulate TNF-alpha production by renal epithelial cells.
American journal of physiology. Renal physiology 2007;292(2):F812-9.
2007: Robert A Frost; Gerald J Nystrom; Leonard S Jefferson; Charles H Lang
Hormone, cytokine, and nutritional regulation of sepsis-induced increases in atrogin-1 and MuRF1 in skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2007;292(2):E501-12.
2006: Hongmei Wang; Neil Kubica; Leif W Ellisen; Leonard S Jefferson; Scot R Kimball
Dexamethasone represses signaling through the mammalian target of rapamycin in muscle cells by enhancing expression of REDD1.
The Journal of biological chemistry 2006;281(51):39128-34.
2006: Stephen J Crozier; Xueqian Zhang; Jufang Wang; Joseph Cheung; Scot R Kimball; Leonard S Jefferson
Activation of signaling pathways and regulatory mechanisms of mRNA translation following myocardial ischemia-reperfusion.
Journal of applied physiology (Bethesda, Md. : 1985) 2006;101(2):576-82.
2006: David L Williamson; Douglas R Bolster; Scot R Kimball; Leonard S Jefferson
Time course changes in signaling pathways and protein synthesis in C2C12 myotubes following AMPK activation by AICAR.
American journal of physiology. Endocrinology and metabolism 2006;291(1):E80-9.
2006: David L Williamson; Neil Kubica; Scot R Kimball; Leonard S Jefferson
Exercise-induced alterations in extracellular signal-regulated kinase 1/2 and mammalian target of rapamycin (mTOR) signalling to regulatory mechanisms of mRNA translation in mouse muscle.
The Journal of physiology 2006;573(Pt 2):497-510.
2006: Laura K Palmer; Sharon L Rannels; Scot R Kimball; Leonard S Jefferson; Ralph L Keil
Inhibition of mammalian translation initiation by volatile anesthetics.
American journal of physiology. Endocrinology and metabolism 2006;290(6):E1267-75.
2006: Jeffery Escobar; Jason W Frank; Agus Suryawan; Hanh V Nguyen; Scot R Kimball; Leonard S Jefferson; Teresa A Davis
Regulation of cardiac and skeletal muscle protein synthesis by individual branched-chain amino acids in neonatal pigs.
American journal of physiology. Endocrinology and metabolism 2006;290(4):E612-21.
2006: Scot R Kimball; Leonard S Jefferson
New functions for amino acids: effects on gene transcription and translation.
The American journal of clinical nutrition 2006;83(2):500S-507S.
2006: Jason W Frank; Jeffery Escobar; Agus Suryawan; Hanh V Nguyen; Scot R Kimball; Leonard S Jefferson; Teresa A Davis
Dietary protein and lactose increase translation initiation factor activation and tissue protein synthesis in neonatal pigs.
American journal of physiology. Endocrinology and metabolism 2006;290(2):E225-33.
2006: Neil Kubica; Leonard S Jefferson; Scot R Kimball
Eukaryotic initiation factor 2B and its role in alterations in mRNA translation that occur under a number of pathophysiological and physiological conditions.
Progress in nucleic acid research and molecular biology 2006;81():271-96.
2006: Scot R Kimball; Leonard S Jefferson
Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesis.
The Journal of nutrition 2006;136(1 Suppl):227S-31S.
2006: Christina Leah B Kline; Tabitha L Schrufer; Leonard S Jefferson; Scot R Kimball
Glucosamine-induced phosphorylation of the alpha-subunit of eukaryotic initiation factor 2 is mediated by the protein kinase R-like endoplasmic-reticulum associated kinase.
The international journal of biochemistry & cell biology 2006;38(5-6):1004-14.
2005: Brian J Krawiec; Robert A Frost; Thomas C Vary; Leonard S Jefferson; Charles H Lang
Hindlimb casting decreases muscle mass in part by proteasome-dependent proteolysis but independent of protein synthesis.
American journal of physiology. Endocrinology and metabolism 2005;289(6):E969-80.
2005: Stephen J Crozier; Thomas C Vary; Scot R Kimball; Leonard S Jefferson
Cellular energy status modulates translational control mechanisms in ischemic-reperfused rat hearts.
American journal of physiology. Heart and circulatory physiology 2005;289(3):H1242-50.
2005: David L Williamson; Scot R Kimball; Leonard S Jefferson
Acute treatment with TNF-alpha attenuates insulin-stimulated protein synthesis in cultures of C2C12 myotubes through a MEK1-sensitive mechanism.
American journal of physiology. Endocrinology and metabolism 2005;289(1):E95-104.
2005: Jason W Frank; Jeffery Escobar; Agus Suryawan; Scot R Kimball; Hanh V Nguyen; Leonard S Jefferson; Teresa A Davis
Protein synthesis and translation initiation factor activation in neonatal pigs fed increasing levels of dietary protein.
The Journal of nutrition 2005;135(6):1374-81.
2005: Jeffery Escobar; Jason W Frank; Agus Suryawan; Hanh V Nguyen; Scot R Kimball; Leonard S Jefferson; Teresa A Davis
Physiological rise in plasma leucine stimulates muscle protein synthesis in neonatal pigs by enhancing translation initiation factor activation.
American journal of physiology. Endocrinology and metabolism 2005;288(5):E914-21.
2005: Ali K Reiter; Douglas R Bolster; Stephen J Crozier; Scot R Kimball; Leonard S Jefferson
Repression of protein synthesis and mTOR signaling in rat liver mediated by the AMPK activator aminoimidazole carboxamide ribonucleoside.
American journal of physiology. Endocrinology and metabolism 2005;288(5):E980-8.
2005: Neil Kubica; Douglas R Bolster; Peter A Farrell; Scot R Kimball; Leonard S Jefferson
Resistance exercise increases muscle protein synthesis and translation of eukaryotic initiation factor 2Bepsilon mRNA in a mammalian target of rapamycin-dependent manner.
The Journal of biological chemistry 2005;280(9):7570-80.
2005: Stephen J Crozier; Scot R Kimball; Sans W Emmert; Joshua C Anthony; Leonard S Jefferson
Oral leucine administration stimulates protein synthesis in rat skeletal muscle.
The Journal of nutrition 2005;135(3):376-82.
2005: Ali K Reiter; Stephen J Crozier; Scot R Kimball; Leonard S Jefferson
Meal feeding alters translational control of gene expression in rat liver.
The Journal of nutrition 2005;135(3):367-75.
2005: Scot R Kimball; Leonard S Jefferson
Role of amino acids in the translational control of protein synthesis in mammals.
Seminars in cell & developmental biology 2005;16(1):21-7.
2004: Scot R Kimball; Brett A Siegfried; Leonard S Jefferson
Glucagon represses signaling through the mammalian target of rapamycin in rat liver by activating AMP-activated protein kinase.
The Journal of biological chemistry 2004;279(52):54103-9.
2004: Ali K Reiter; Tracy G Anthony; Joshua C Anthony; Leonard S Jefferson; Scot R Kimball
The mTOR signaling pathway mediates control of ribosomal protein mRNA translation in rat liver.
The international journal of biochemistry & cell biology 2004;36(11):2169-79.
2004: Scot R Kimball; James P O'Malley; Joshua C Anthony; Stephen J Crozier; Leonard S Jefferson
Assessment of biomarkers of protein anabolism in skeletal muscle during the life span of the rat: sarcopenia despite elevated protein synthesis.
American journal of physiology. Endocrinology and metabolism 2004;287(4):E772-80.
2004: Douglas R Bolster; Thomas C Vary; Scot R Kimball; Leonard S Jefferson
Leucine regulates translation initiation in rat skeletal muscle via enhanced eIF4G phosphorylation.
The Journal of nutrition 2004;134(7):1704-10.
2004: Pamela M J O'Connor; Scot R Kimball; Agus Suryawan; Jill A Bush; Hanh V Nguyen; Leonard S Jefferson; Teresa A Davis
Regulation of neonatal liver protein synthesis by insulin and amino acids in pigs.
American journal of physiology. Endocrinology and metabolism 2004;286(6):E994-E1003.
2004: Douglas R Bolster; Leonard S Jefferson; Scot R Kimball
Regulation of protein synthesis associated with skeletal muscle hypertrophy by insulin-, amino acid- and exercise-induced signalling.
The Proceedings of the Nutrition Society 2004;63(2):351-6.
2004: Renan A Orellana; Scot R Kimball; Hanh V Nguyen; Jill A Bush; Agus Suryawan; M Carole Thivierge; Leonard S Jefferson; Teresa A Davis
Regulation of muscle protein synthesis in neonatal pigs during prolonged endotoxemia.
Pediatric research 2004;55(3):442-9.
2004: Scot R Kimball; Rick L Horetsky; Leonard S Jefferson
A microtiter plate assay for assessing the interaction of eukaryotic initiation factor eIF4E with eIF4G and eIF4E binding protein-1.
Analytical biochemistry 2004;325(2):364-8.
2004: Neil Kubica; Scot R Kimball; Leonard S Jefferson; Peter A Farrell
Alterations in the expression of mRNAs and proteins that code for species relevant to eIF2B activity after an acute bout of resistance exercise.
Journal of applied physiology (Bethesda, Md. : 1985) 2004;96(2):679-87.
2004: Scot R Kimball; Leonard S Jefferson
Regulation of global and specific mRNA translation by oral administration of branched-chain amino acids.
Biochemical and biophysical research communications 2004;313(2):423-7.
2004: Scot R Kimball; Leonard S Jefferson
Molecular mechanisms through which amino acids mediate signaling through the mammalian target of rapamycin.
Current opinion in clinical nutrition and metabolic care 2004;7(1):39-44.
2004: Agus Suryawan; Pamela M J O'Connor; Scot R Kimball; Jill A Bush; Hanh V Nguyen; Leonard S Jefferson; Teresa A Davis
Amino acids do not alter the insulin-induced activation of the insulin signaling pathway in neonatal pigs.
The Journal of nutrition 2004;134(1):24-30.
2003: Charles H Lang; Robert A Frost; Nobuko Deshpande; Vinayshree Kumar; Thomas C Vary; Leonard S Jefferson; Scot R Kimball
Alcohol impairs leucine-mediated phosphorylation of 4E-BP1, S6K1, eIF4G, and mTOR in skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2003;285(6):E1205-15.
2003: Douglas R Bolster; Neil Kubica; Stephen J Crozier; David L Williamson; Peter A Farrell; Scot R Kimball; Leonard S Jefferson
Immediate response of mammalian target of rapamycin (mTOR)-mediated signalling following acute resistance exercise in rat skeletal muscle.
The Journal of physiology 2003;553(Pt 1):213-20.
2003: Stephen J Crozier; Joshua C Anthony; Charles M Schworer; Ali K Reiter; Tracy G Anthony; Scot R Kimball; Leonard S Jefferson
Tissue-specific regulation of protein synthesis by insulin and free fatty acids.
American journal of physiology. Endocrinology and metabolism 2003;285(4):E754-62.
2003: Scot R Kimball; Renan A Orellana; Pamela M J O'Connor; Agus Suryawan; Jill A Bush; Hanh V Nguyen; M Carole Thivierge; Leonard S Jefferson; Teresa A Davis
Endotoxin induces differential regulation of mTOR-dependent signaling in skeletal muscle and liver of neonatal pigs.
American journal of physiology. Endocrinology and metabolism 2003;285(3):E637-44.
2003: Douglas R Bolster; Scot R Kimball; Leonard S Jefferson
Translational control mechanisms modulate skeletal muscle gene expression during hypertrophy.
Exercise and sport sciences reviews 2003;31(3):111-6.
2003: Pamela M J O'Connor; Scot R Kimball; Agus Suryawan; Jill A Bush; Hanh V Nguyen; Leonard S Jefferson; Teresa A Davis
Regulation of translation initiation by insulin and amino acids in skeletal muscle of neonatal pigs.
American journal of physiology. Endocrinology and metabolism 2003;285(1):E40-53.
2003: Leonard S Jefferson; Scot R Kimball
Amino acids as regulators of gene expression at the level of mRNA translation.
The Journal of nutrition 2003;133(6 Suppl 1):2046S-2051S.
2003: Jill A Bush; Scot R Kimball; Pamela M J O'Connor; Agus Suryawan; Renan A Orellana; Hanh V Nguyen; Leonard S Jefferson; Teresa A Davis
Translational control of protein synthesis in muscle and liver of growth hormone-treated pigs.
Endocrinology 2003;144(4):1273-83.
2003: Scot R Kimball; Rick L Horetsky; David Ron; Leonard S Jefferson; Heather P Harding
Mammalian stress granules represent sites of accumulation of stalled translation initiation complexes.
American journal of physiology. Cell physiology 2003;284(2):C273-84.
2002: Stephen J Crozier; Douglas R Bolster; Ali K Reiter; Scot R Kimball; Leonard S Jefferson
Beta -oxidation of free fatty acids is required to maintain translational control of protein synthesis in heart.
American journal of physiology. Endocrinology and metabolism 2002;283(6):E1144-50.
2002: Peichuan Zhang; Barbara C McGrath; Jamie Reinert; Deanne S Olsen; Li Lei; Sangeeta Gill; Sheree A Wek; Krishna M Vattem; Ronald C Wek; Scot R Kimball; Leonard S Jefferson; Douglas R Cavener
The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice.
Molecular and cellular biology 2002;22(19):6681-8.
2002: Scot R Kimball; Peter A Farrell; Leonard S Jefferson
Invited Review: Role of insulin in translational control of protein synthesis in skeletal muscle by amino acids or exercise.
Journal of applied physiology (Bethesda, Md. : 1985) 2002;93(3):1168-80.
2002: Christopher J Lynch; Brian J Patson; Joshua Anthony; Alain Vaval; Leonard S Jefferson; Thomas C Vary
Leucine is a direct-acting nutrient signal that regulates protein synthesis in adipose tissue.
American journal of physiology. Endocrinology and metabolism 2002;283(3):E503-13.
2002: O Jameel Shah; Scot R Kimball; Leonard S Jefferson
The Src-family tyrosine kinase inhibitor PP1 interferes with the activation of ribosomal protein S6 kinases.
The Biochemical journal 2002;366(Pt 1):57-62.
2002: Douglas R Bolster; Stephen J Crozier; Scot R Kimball; Leonard S Jefferson
AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling.
The Journal of biological chemistry 2002;277(27):23977-80.
2002: Joshua C Anthony; Charles H Lang; Stephen J Crozier; Tracy G Anthony; David A MacLean; Scot R Kimball; Leonard S Jefferson
Contribution of insulin to the translational control of protein synthesis in skeletal muscle by leucine.
American journal of physiology. Endocrinology and metabolism 2002;282(5):E1092-101.
2002: Joshua C Anthony; Ali K Reiter; Tracy G Anthony; Stephen J Crozier; Charles H Lang; David A MacLean; Scot R Kimball; Leonard S Jefferson
Orally administered leucine enhances protein synthesis in skeletal muscle of diabetic rats in the absence of increases in 4E-BP1 or S6K1 phosphorylation.
Diabetes 2002;51(4):928-36.
2002: Scot R Kimball; Peter A Farrell; Hanh V Nguyen; Leonard S Jefferson; Teresa A Davis
Developmental decline in components of signal transduction pathways regulating protein synthesis in pig muscle.
American journal of physiology. Endocrinology and metabolism 2002;282(3):E585-92.
2002: O Jameel Shah; Jorge A Iniguez-Lluhi; Angela Romanelli; Scot R Kimball; Leonard S Jefferson
The activated glucocorticoid receptor modulates presumptive autoregulation of ribosomal protein S6 protein kinase, p70 S6K.
The Journal of biological chemistry 2002;277(4):2525-33.
2002: Scot R Kimball; Leonard S Jefferson
Control of protein synthesis by amino acid availability.
Current opinion in clinical nutrition and metabolic care 2002;5(1):63-7.
2001: Leonard S Jefferson; Scot R Kimball
Translational control of protein synthesis: implications for understanding changes in skeletal muscle mass.
International journal of sport nutrition and exercise metabolism 2001;11 Suppl():S143-9.
2001: Thomas C Vary; Leonard S Jefferson; Scot R Kimball
Insulin fails to stimulate muscle protein synthesis in sepsis despite unimpaired signaling to 4E-BP1 and S6K1.
American journal of physiology. Endocrinology and metabolism 2001;281(5):E1045-53.
2001: Leonard S Jefferson; Scot R Kimball
Amino acid regulation of gene expression.
The Journal of nutrition 2001;131(9 Suppl):2460S-6S; discussion 2486S-7S.
2001: Tracy G Anthony; Ali K Reiter; Joshua C Anthony; Scot R Kimball; Leonard S Jefferson
Deficiency of dietary EAA preferentially inhibits mRNA translation of ribosomal proteins in liver of meal-fed rats.
American journal of physiology. Endocrinology and metabolism 2001;281(3):E430-9.
2001: John C Kostyak; Scot R Kimball; Leonard S Jefferson; Peter A Farrell
Severe diabetes inhibits resistance exercise-induced increase in eukaryotic initiation factor 2B activity.
Journal of applied physiology (Bethesda, Md. : 1985) 2001;91(1):79-84.
2001: Tracy G Anthony; Joshua C Anthony; F Yoshizawa; Scot R Kimball; Leonard S Jefferson
Oral administration of leucine stimulates ribosomal protein mRNA translation but not global rates of protein synthesis in the liver of rats.
The Journal of nutrition 2001;131(4):1171-6.
2001: Joshua C Anthony; Tracy G Anthony; Scot R Kimball; Leonard S Jefferson
Signaling pathways involved in translational control of protein synthesis in skeletal muscle by leucine.
The Journal of nutrition 2001;131(3):856S-860S.
2001: Scot R Kimball; Michael J Clemens; Vivienne J Tilleray; R C Wek; Rick L Horetsky; Leonard S Jefferson
The double-stranded RNA-activated protein kinase PKR is dispensable for regulation of translation initiation in response to either calcium mobilization from the endoplasmic reticulum or essential amino acid starvation.
Biochemical and biophysical research communications 2001;280(1):293-300.
2001: Scot R Kimball; Leonard S Jefferson
Regulation of protein synthesis by branched-chain amino acids.
Current opinion in clinical nutrition and metabolic care 2001;4(1):39-43.
2000: Teresa A Davis; Hanh V Nguyen; Agus Suryawan; Jill A Bush; Leonard S Jefferson; Scot R Kimball
Developmental changes in the feeding-induced stimulation of translation initiation in muscle of neonatal pigs.
American journal of physiology. Endocrinology and metabolism 2000;279(6):E1226-34.
2000: O Jameel Shah; Joshua C Anthony; Scot R Kimball; Leonard S Jefferson
Glucocorticoids oppose translational control by leucine in skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2000;279(5):E1185-90.
2000: Scot R Kimball; Leonard S Jefferson; Hanh V Nguyen; Agus Suryawan; Jill A Bush; Teresa A Davis
Feeding stimulates protein synthesis in muscle and liver of neonatal pigs through an mTOR-dependent process.
American journal of physiology. Endocrinology and metabolism 2000;279(5):E1080-7.
2000: Katherine M Hannan; Ross D Hannan; S D Smith; Leonard S Jefferson; Mingyue Lun; Lawrence Rothblum
Rb and p130 regulate RNA polymerase I transcription: Rb disrupts the interaction between UBF and SL-1.
Oncogene 2000;19(43):4988-99.
2000: Joshua C Anthony; F Yoshizawa; Tracy G Anthony; Thomas C Vary; Leonard S Jefferson; Scot R Kimball
Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway.
The Journal of nutrition 2000;130(10):2413-9.
2000: O Jameel Shah; Joshua C Anthony; Scot R Kimball; Leonard S Jefferson
4E-BP1 and S6K1: translational integration sites for nutritional and hormonal information in muscle.
American journal of physiology. Endocrinology and metabolism 2000;279(4):E715-29.
2000: P T Pham; S J Heydrick; HL Fox; Scot R Kimball; Leonard S Jefferson; Christopher J Lynch
Assessment of cell-signaling pathways in the regulation of mammalian target of rapamycin (mTOR) by amino acids in rat adipocytes.
Journal of cellular biochemistry 2000;79(3):427-41.
2000: Katherine M Hannan; Brian Kennedy; Alice H Cavanaugh; Ross D Hannan; Iwona Hirschler-Laszkiewicz; Leonard S Jefferson; Lawrence Rothblum
RNA polymerase I transcription in confluent cells: Rb downregulates rDNA transcription during confluence-induced cell cycle arrest.
Oncogene 2000;19(31):3487-97.
2000: O Jameel Shah; Scot R Kimball; Leonard S Jefferson
Glucocorticoids abate p70(S6k) and eIF4E function in L6 skeletal myoblasts.
American journal of physiology. Endocrinology and metabolism 2000;279(1):E74-82.
2000: Tracy G Anthony; JR Fabian; Scot R Kimball; Leonard S Jefferson
Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation.
Biochimica et biophysica acta 2000;1492(1):56-62.
2000: Charles H Lang; Robert A Frost; Leonard S Jefferson; Scot R Kimball; Thomas C Vary
Endotoxin-induced decrease in muscle protein synthesis is associated with changes in eIF2B, eIF4E, and IGF-I.
American journal of physiology. Endocrinology and metabolism 2000;278(6):E1133-43.
2000: O Jameel Shah; Scot R Kimball; Leonard S Jefferson
Among translational effectors, p70S6k is uniquely sensitive to inhibition by glucocorticoids.
The Biochemical journal 2000;347(Pt 2):389-97.
2000: Christopher J Lynch; HL Fox; Thomas C Vary; Leonard S Jefferson; Scot R Kimball
Regulation of amino acid-sensitive TOR signaling by leucine analogues in adipocytes.
Journal of cellular biochemistry 2000;77(2):234-51.
2000: Peter A Farrell; JM Hernandez; MJ Fedele; Thomas C Vary; Scot R Kimball; Leonard S Jefferson
Eukaryotic initiation factors and protein synthesis after resistance exercise in rats.
Journal of applied physiology (Bethesda, Md. : 1985) 2000;88(3):1036-42.
2000: Joshua C Anthony; Tracy G Anthony; Scot R Kimball; Thomas C Vary; Leonard S Jefferson
Orally administered leucine stimulates protein synthesis in skeletal muscle of postabsorptive rats in association with increased eIF4F formation.
The Journal of nutrition 2000;130(2):139-45.
2000: O Jameel Shah; Scot R Kimball; Leonard S Jefferson
Acute attenuation of translation initiation and protein synthesis by glucocorticoids in skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2000;278(1):E76-82.
2000: Thomas C Vary; Leonard S Jefferson; Scot R Kimball
Role of eIF4E in stimulation of protein synthesis by IGF-I in perfused rat skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2000;278(1):E58-64.
2000: MJ Fedele; JM Hernandez; Charles H Lang; Thomas C Vary; Scot R Kimball; Leonard S Jefferson; Peter A Farrell
Severe diabetes prohibits elevations in muscle protein synthesis after acute resistance exercise in rats.
Journal of applied physiology (Bethesda, Md. : 1985) 2000;88(1):102-8.
1999: O Jameel Shah; David Antonetti; Scot R Kimball; Leonard S Jefferson
Leucine, glutamine, and tyrosine reciprocally modulate the translation initiation factors eIF4F and eIF2B in perfused rat liver.
The Journal of biological chemistry 1999;274(51):36168-75.
1999: Thomas C Vary; Leonard S Jefferson; Scot R Kimball
Amino acid-induced stimulation of translation initiation in rat skeletal muscle.
The American journal of physiology 1999;277(6 Pt 1):E1077-86.
1999: Charles H Lang; D Wu; Robert A Frost; Leonard S Jefferson; Thomas C Vary; Scot R Kimball
Chronic alcohol feeding impairs hepatic translation initiation by modulating eIF2 and eIF4E.
The American journal of physiology 1999;277(5 Pt 1):E805-14.
1999: Peter A Farrell; MJ Fedele; J Hernandez; JD Fluckey; J L Miller; Charles H Lang; Thomas C Vary; Scot R Kimball; Leonard S Jefferson
Hypertrophy of skeletal muscle in diabetic rats in response to chronic resistance exercise.
Journal of applied physiology (Bethesda, Md. : 1985) 1999;87(3):1075-82.
1999: Charles H Lang; D Wu; Robert A Frost; Leonard S Jefferson; Scot R Kimball; Thomas C Vary
Inhibition of muscle protein synthesis by alcohol is associated with modulation of eIF2B and eIF4E.
The American journal of physiology 1999;277(2 Pt 1):E268-76.
1999: Scot R Kimball; Lisa M Shantz; Rick L Horetsky; Leonard S Jefferson
Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR-mediated changes in availability of eIF4E and phosphorylation of ribosomal protein S6.
The Journal of biological chemistry 1999;274(17):11647-52.
1999: Peter A Farrell; MJ Fedele; Thomas C Vary; Scot R Kimball; Charles H Lang; Leonard S Jefferson
Regulation of protein synthesis after acute resistance exercise in diabetic rats.
The American journal of physiology 1999;276(4 Pt 1):E721-7.
1999: Leonard S Jefferson; JR Fabian; Scot R Kimball
Glycogen synthase kinase-3 is the predominant insulin-regulated eukaryotic initiation factor 2B kinase in skeletal muscle.
The international journal of biochemistry & cell biology 1999;31(1):191-200.
1998: Peter A Farrell; MJ Fedele; Thomas C Vary; Scot R Kimball; Leonard S Jefferson
Effects of intensity of acute-resistance exercise on rates of protein synthesis in moderately diabetic rats.
Journal of applied physiology (Bethesda, Md. : 1985) 1998;85(6):2291-7.
1998: Scot R Kimball; Rick L Horetsky; Leonard S Jefferson
Implication of eIF2B rather than eIF4E in the regulation of global protein synthesis by amino acids in L6 myoblasts.
The Journal of biological chemistry 1998;273(47):30945-53.
1998: F Yoshizawa; Scot R Kimball; Thomas C Vary; Leonard S Jefferson
Effect of dietary protein on translation initiation in rat skeletal muscle and liver.
The American journal of physiology 1998;275(5 Pt 1):E814-20.
1998: HL Fox; P T Pham; Scot R Kimball; Leonard S Jefferson; Christopher J Lynch
Amino acid effects on translational repressor 4E-BP1 are mediated primarily by L-leucine in isolated adipocytes.
The American journal of physiology 1998;275(5 Pt 1):C1232-8.
1998: Katherine M Hannan; Lawrence Rothblum; Leonard S Jefferson
Regulation of ribosomal DNA transcription by insulin.
The American journal of physiology 1998;275(1 Pt 1):C130-8.
1998: JR Fabian; Scot R Kimball; Leonard S Jefferson
Reconstitution and purification of eukaryotic initiation factor 2B (eIF2B) expressed in Sf21 insect cells.
Protein expression and purification 1998;13(1):16-22.
1998: Scot R Kimball; JR Fabian; Graham D Pavitt; Alan G Hinnebusch; Leonard S Jefferson
Regulation of guanine nucleotide exchange through phosphorylation of eukaryotic initiation factor eIF2alpha. Role of the alpha- and delta-subunits of eiF2b.
The Journal of biological chemistry 1998;273(21):12841-5.
1998: Scot R Kimball; Rick L Horetsky; R Jagus; Leonard S Jefferson
Expression and purification of the alpha-subunit of eukaryotic initiation factor eIF2: use as a kinase substrate.
Protein expression and purification 1998;12(3):415-9.
1998: Scot R Kimball; N K Heinzinger; Rick L Horetsky; Leonard S Jefferson
Identification of interprotein interactions between the subunits of eukaryotic initiation factors eIF2 and eIF2B.
The Journal of biological chemistry 1998;273(5):3039-44.
1998: Scot R Kimball; Rick L Horetsky; Leonard S Jefferson
Signal transduction pathways involved in the regulation of protein synthesis by insulin in L6 myoblasts.
The American journal of physiology 1998;274(1 Pt 1):C221-8.
1998: HL Fox; Scot R Kimball; Leonard S Jefferson; Christopher J Lynch
Amino acids stimulate phosphorylation of p70S6k and organization of rat adipocytes into multicellular clusters.
The American journal of physiology 1998;274(1 Pt 1):C206-13.
1997: F Yoshizawa; Scot R Kimball; Leonard S Jefferson
Modulation of translation initiation in rat skeletal muscle and liver in response to food intake.
Biochemical and biophysical research communications 1997;240(3):825-31.
1997: JR Fabian; Scot R Kimball; N K Heinzinger; Leonard S Jefferson
Subunit assembly and guanine nucleotide exchange activity of eukaryotic initiation factor-2B expressed in Sf9 cells.
The Journal of biological chemistry 1997;272(19):12359-65.
1997: Scot R Kimball; C V Jurasinski; J C Lawrence; Leonard S Jefferson
Insulin stimulates protein synthesis in skeletal muscle by enhancing the association of eIF-4E and eIF-4G.
The American journal of physiology 1997;272(2 Pt 1):C754-9.
1996: Nigel T Price; H Mellor; B L Craddock; K M Flowers; Scot R Kimball; T Wilmer; Leonard S Jefferson; Christopher G Proud
eIF2B, the guanine nucleotide-exchange factor for eukaryotic initiation factor 2. Sequence conservation between the alpha, beta and delta subunits of eIF2B from mammals and yeast.
The Biochemical journal 1996;318 ( Pt 2)():637-43.
1996: Nigel T Price; Scot R Kimball; Leonard S Jefferson; Christopher G Proud
Cloning of cDNA for the gamma-subunit of mammalian translation initiation factor 2B, the guanine nucleotide-exchange factor for eukaryotic initiation factor 2.
The Biochemical journal 1996;318 ( Pt 2)():631-6.
1996: J D Fluckey; Thomas C Vary; Leonard S Jefferson; William J Evans; Peter A Farrell
Insulin stimulation of protein synthesis in rat skeletal muscle following resistance exercise is maintained with advancing age.
The journals of gerontology. Series A, Biological sciences and medical sciences 1996;51(5):B323-30.
1996: K M Flowers; H Mellor; Robert L Matts; Scot R Kimball; Leonard S Jefferson
Cloning and characterization of complementary and genomic DNAs encoding the epsilon-subunit of rat translation initiation factor-2B.
Biochimica et biophysica acta 1996;1307(3):318-24.
1996: A I Asuru; H Mellor; N S Thomas; Linda Yu; J J Chen; J S Crosby; Steven D Hartson; Scot R Kimball; Leonard S Jefferson; Robert L Matts
Cloning and characterization of cDNAs encoding the epsilon-subunit of eukaryotic initiation factor-2B from rabbit and human.
Biochimica et biophysica acta 1996;1307(3):309-17.
1996: Scot R Kimball; M Yancisin; Rick L Horetsky; Leonard S Jefferson
Translational and pretranslational regulation of protein synthesis by amino acid availability in primary cultures of rat hepatocytes.
The international journal of biochemistry & cell biology 1996;28(3):285-94.
1996: J D Fluckey; Thomas C Vary; Leonard S Jefferson; Peter A Farrell
Augmented insulin action on rates of protein synthesis after resistance exercise in rats.
The American journal of physiology 1996;270(2 Pt 1):E313-9.
1996: Scot R Kimball; Leonard S Jefferson; Patrick Fadden; Timothy A J Haystead; John C Lawrence
Insulin and diabetes cause reciprocal changes in the association of eIF-4E and PHAS-I in rat skeletal muscle.
The American journal of physiology 1996;270(2 Pt 1):C705-9.
1996: Laure Voisin; Kristen Gray; K M Flowers; Scot R Kimball; Leonard S Jefferson; Thomas C Vary
Altered expression of eukaryotic initiation factor 2B in skeletal muscle during sepsis.
The American journal of physiology 1996;270(1 Pt 1):E43-50.
1996: Scot R Kimball; H Mellor; K M Flowers; Leonard S Jefferson
Role of translation initiation factor eIF-2B in the regulation of protein synthesis in mammalian cells.
Progress in nucleic acid research and molecular biology 1996;54():165-96.
1995: K M Flowers; H Mellor; Scot R Kimball; Leonard S Jefferson
Structure and sequence of the gene encoding the alpha-subunit of rat translation initiation factor-2B.
Biochimica et biophysica acta 1995;1264(2):163-7.
1995: Scot R Kimball; Leonard S Jefferson
Allosteric regulation of eukaryotic initiation factor eIF-2B by adenine nucleotides.
Biochemical and biophysical research communications 1995;212(3):1074-81.
1995: K M Flowers; Scot R Kimball; Richard C Feldhoff; Alan G Hinnebusch; Leonard S Jefferson
Molecular cloning and characterization of cDNA encoding the alpha subunit of the rat protein synthesis initiation factor eIF-2B.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(10):4274-8.
1995: Scot R Kimball; Rick L Horetsky; Leonard S Jefferson
Hormonal regulation of albumin gene expression in primary cultures of rat hepatocytes.
The American journal of physiology 1995;268(1 Pt 1):E6-14.
1994: Scot R Kimball; Anne M Karinch; Richard C Feldhoff; H Mellor; Leonard S Jefferson
Purification and characterization of eukaryotic translational initiation factor eIF-2B from liver.
Biochimica et biophysica acta 1994;1201(3):473-81.
1994: H Mellor; K M Flowers; Scot R Kimball; Leonard S Jefferson
Cloning and characterization of a cDNA encoding rat PKR, the double-stranded RNA-dependent eukaryotic initiation factor-2 kinase.
Biochimica et biophysica acta 1994;1219(3):693-6.
1994: H Mellor; Scot R Kimball; Leonard S Jefferson
Brefeldin A inhibits protein synthesis through the phosphorylation of the alpha-subunit of eukaryotic initiation factor-2.
FEBS letters 1994;350(1):143-6.
1994: H Mellor; K M Flowers; Scot R Kimball; Leonard S Jefferson
Cloning and characterization of cDNA encoding rat hemin-sensitive initiation factor-2 alpha (eIF-2 alpha) kinase. Evidence for multitissue expression.
The Journal of biological chemistry 1994;269(14):10201-4.
1994: Scot R Kimball; Leonard S Jefferson
Mechanisms of translational control in liver and skeletal muscle.
Biochimie 1994;76(8):729-36.
1993: David Antonetti; Scot R Kimball; Rick L Horetsky; Leonard S Jefferson
Regulation of rDNA transcription by insulin in primary cultures of rat hepatocytes.
The Journal of biological chemistry 1993;268(34):25277-84.
1993: Richard C Feldhoff; Anne M Karinch; Scot R Kimball; Leonard S Jefferson
Purification of eukaryotic initiation factors eIF-2, eIF-2B and eIF-2 alpha kinase from bovine liver.
Preparative biochemistry 1993;23(3):363-74.
1993: K M Ojamaa; Scot R Kimball; Leonard S Jefferson
Aminoacylation of initiator methionyl-tRNA(i) under conditions inhibitory to initiation of protein synthesis.
The American journal of physiology 1993;264(2 Pt 1):E257-63.
1993: Anne M Karinch; Scot R Kimball; Thomas C Vary; Leonard S Jefferson
Regulation of eukaryotic initiation factor-2B activity in muscle of diabetic rats.
The American journal of physiology 1993;264(1 Pt 1):E101-8.
1992: C J Hsu; Scot R Kimball; David Antonetti; Leonard S Jefferson
Effects of insulin on total RNA, poly(A)+ RNA, and mRNA in primary cultures of rat hepatocytes.
The American journal of physiology 1992;263(6 Pt 1):E1106-12.
1992: Scot R Kimball; Leonard S Jefferson
Regulation of protein synthesis by modulation of intracellular calcium in rat liver.
The American journal of physiology 1992;263(5 Pt 1):E958-64.
1992: Scot R Kimball; Thomas C Vary; Leonard S Jefferson
Age-dependent decrease in the amount of eukaryotic initiation factor 2 in various rat tissues.
The Biochemical journal 1992;286 ( Pt 1)():263-8.
1991: Scot R Kimball; Leonard S Jefferson
Inhibition of microsomal calcium sequestration causes an impairment of initiation of protein synthesis in perfused rat liver.
Biochemical and biophysical research communications 1991;177(3):1082-6.
1991: J D Kent; Scot R Kimball; Leonard S Jefferson
Effect of diabetes and insulin treatment of diabetic rats on total RNA, poly(A)+ RNA, and mRNA in skeletal muscle.
The American journal of physiology 1991;260(3 Pt 1):C409-16.
1991: Scot R Kimball; David Antonetti; R M Brawley; Leonard S Jefferson
Mechanism of inhibition of peptide chain initiation by amino acid deprivation in perfused rat liver. Regulation involving inhibition of eukaryotic initiation factor 2 alpha phosphatase activity.
The Journal of biological chemistry 1991;266(3):1969-76.
1991: Scot R Kimball; Leonard S Jefferson
Regulation of initiation of protein synthesis by insulin in skeletal muscle.
Acta diabetologica 1991;28(2):134-9.
1990: Scot R Kimball; Leonard S Jefferson
Mechanism of the inhibition of protein synthesis by vasopressin in rat liver.
The Journal of biological chemistry 1990;265(28):16794-8.
1989: W V Everson; K E Flaim; D M Susco; Scot R Kimball; Leonard S Jefferson
Effect of amino acid deprivation on initiation of protein synthesis in rat hepatocytes.
The American journal of physiology 1989;256(1 Pt 1):C18-27.
1989: Scot R Kimball; W V Everson; K E Flaim; Leonard S Jefferson
Initiation of protein synthesis in a cell-free system prepared from rat hepatocytes.
The American journal of physiology 1989;256(1 Pt 1):C28-34.
1988: Scot R Kimball; Leonard S Jefferson
Effect of diabetes on guanine nucleotide exchange factor activity in skeletal muscle and heart.
Biochemical and biophysical research communications 1988;156(2):706-11.
1988: A E Lewandowski; W S Liao; C A Stinson-Fisher; J D Kent; Leonard S Jefferson
Effects of experimentally induced nephrosis on protein synthesis in rat liver.
The American journal of physiology 1988;254(5 Pt 1):C634-42.
1988: Scot R Kimball; S L Rannels; M B Elensky; Leonard S Jefferson
Quantitation of proteins by dot-immunobinding assay. A comparison of visualization methods using eukaryotic initiation factor 2 and a monospecific antibody.
Journal of immunological methods 1988;106(2):217-23.
1987: Scot R Kimball; W V Everson; L M Myers; Leonard S Jefferson
Purification and characterization of eukaryotic initiation factor 2 and a guanine nucleotide exchange factor from rat liver.
The Journal of biological chemistry 1987;262(5):2220-7.
1983: Leonard S Jefferson; W S Liao; D E Peavy; T B Miller; M C Appel; J M Taylor
Diabetes-induced alterations in liver protein synthesis. Changes in the relative abundance of mRNAs for albumin and other plasma proteins.
The Journal of biological chemistry 1983;258(2):1369-75.
1982: K E Flaim; W S Liao; D E Peavy; J M Taylor; Leonard S Jefferson
The role of amino acids in the regulation of protein synthesis in perfused rat liver. II. Effects of amino acid deficiency on peptide chain initiation, polysomal aggregation, and distribution of albumin mRNA.
The Journal of biological chemistry 1982;257(6):2939-46.
1982: K E Flaim; D E Peavy; W V Everson; Leonard S Jefferson
The role of amino acids in the regulation of protein synthesis in perfused rat liver. I. Reduction in rates of synthesis resulting from amino acid deprivation and recovery during flow-through perfusion.
The Journal of biological chemistry 1982;257(6):2932-8.
1980: Leonard S Jefferson; T A Boyd; K E Flaim; D E Peavy
Regulation of protein synthesis in perfused preparations of rat heart, skeletal muscle and liver.
Biochemical Society transactions 1980;8(3):282-3.